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Found 70 hits Enz. Inhib. hit(s) with Target = 'c-Jun N-terminal kinase 3' AND taxid = 10116   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50059650
PNG
(CHEMBL3220495)
Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2C(N)=O)n1)N1CCOCC1
Show InChI InChI=1S/C22H23ClN6O3/c1-31-19-12-14(29-8-10-32-11-9-29)6-7-18(19)27-22-25-13-16(23)21(28-22)26-17-5-3-2-4-15(17)20(24)30/h2-7,12-13H,8-11H2,1H3,(H2,24,30)(H2,25,26,27,28)
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n/an/a 3n/an/an/an/an/an/a



Eberhard Karls Universit£t T£bingen

Curated by ChEMBL


Assay Description
Inhibition of JNK3-mediated c-jun phosphorylation in rat INS1 cells


J Med Chem 58: 72-95 (2015)

More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50169985
PNG
(4-(2-(4-(benzo[d]thiazol-2(3H)-ylidene(cyano)methy...)
Show SMILES NS(=O)(=O)c1ccc(CCNc2nccc(n2)C(C#N)c2nc3ccccc3s2)cc1
Show InChI InChI=1S/C21H18N6O2S2/c22-13-16(20-26-18-3-1-2-4-19(18)30-20)17-10-12-25-21(27-17)24-11-9-14-5-7-15(8-6-14)31(23,28)29/h1-8,10,12,16H,9,11H2,(H2,23,28,29)(H,24,25,27)
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n/an/a 41n/an/an/an/an/an/a



Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)

More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50303646
PNG
(4-(3-Fluoro-5-morpholinophenyl)-N-(4-(3-morpholino...)
Show SMILES Fc1cc(cc(c1)-c1ccnc(Nc2ccc(cc2)-n2cnc(n2)N2CCOCC2)n1)N1CCOCC1
Show InChI InChI=1S/C26H27FN8O2/c27-20-15-19(16-23(17-20)33-7-11-36-12-8-33)24-5-6-28-25(31-24)30-21-1-3-22(4-2-21)35-18-29-26(32-35)34-9-13-37-14-10-34/h1-6,15-18H,7-14H2,(H,28,30,31)
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n/an/a 54n/an/an/an/an/an/a



Eberhard Karls Universit£t T£bingen

Curated by ChEMBL


Assay Description
Inhibition of JNK3-mediated c-jun phosphorylation in rat INS1 cells


J Med Chem 58: 72-95 (2015)

More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50169980
PNG
(CHEMBL363254 | [3H-Benzothiazol-(2Z)-ylidene]-{2-[...)
Show SMILES Cn1cnc(CCNc2nccc(n2)C(C#N)c2nc3ccccc3s2)c1
Show InChI InChI=1S/C19H17N7S/c1-26-11-13(23-12-26)6-8-21-19-22-9-7-15(25-19)14(10-20)18-24-16-4-2-3-5-17(16)27-18/h2-5,7,9,11-12,14H,6,8H2,1H3,(H,21,22,25)
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Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)

More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50170008
PNG
(CHEMBL372708 | {2-[2-(4-Amino-phenyl)-ethylamino]-...)
Show SMILES Nc1ccc(CCNc2nccc(n2)C(C#N)c2nc3ccccc3s2)cc1
Show InChI InChI=1S/C21H18N6S/c22-13-16(20-26-18-3-1-2-4-19(18)28-20)17-10-12-25-21(27-17)24-11-9-14-5-7-15(23)8-6-14/h1-8,10,12,16H,9,11,23H2,(H,24,25,27)
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Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)

More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50169998
PNG
(CHEMBL191581 | CHEMBL254651 | [3H-Benzothiazol-(2Z...)
Show SMILES N#CC(c1nc2ccccc2s1)c1ccnc(NCCc2cnc[nH]2)n1
Show InChI InChI=1S/C18H15N7S/c19-9-13(17-24-15-3-1-2-4-16(15)26-17)14-6-8-22-18(25-14)21-7-5-12-10-20-11-23-12/h1-4,6,8,10-11,13H,5,7H2,(H,20,23)(H,21,22,25)
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n/an/a 80n/an/an/an/an/an/a



Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)

More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50169959
PNG
(2-(benzo[d]thiazol-2(3H)-ylidene)-2-(2-(2-(pyridin...)
Show SMILES N#CC(c1nc2ccccc2s1)c1ccnc(NCCc2cccnc2)n1
Show InChI InChI=1S/C20H16N6S/c21-12-15(19-25-17-5-1-2-6-18(17)27-19)16-8-11-24-20(26-16)23-10-7-14-4-3-9-22-13-14/h1-6,8-9,11,13,15H,7,10H2,(H,23,24,26)
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n/an/a 120n/an/an/an/an/an/a



Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)

More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50169999
PNG
(CHEMBL371113 | [3H-Benzothiazol-(2Z)-ylidene]-{2-[...)
Show SMILES Cn1cncc1CCNc1nccc(n1)C(C#N)c1nc2ccccc2s1
Show InChI InChI=1S/C19H17N7S/c1-26-12-21-11-13(26)6-8-22-19-23-9-7-15(25-19)14(10-20)18-24-16-4-2-3-5-17(16)27-18/h2-5,7,9,11-12,14H,6,8H2,1H3,(H,22,23,25)
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n/an/a 143n/an/an/an/an/an/a



Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)

More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50170017
PNG
(CHEMBL189841 | [3H-Benzothiazol-(2Z)-ylidene]-[2-(...)
Show SMILES N#CC(c1nc2ccccc2s1)c1ccnc(NCCCn2ccnc2)n1
Show InChI InChI=1S/C19H17N7S/c20-12-14(18-24-16-4-1-2-5-17(16)27-18)15-6-8-23-19(25-15)22-7-3-10-26-11-9-21-13-26/h1-2,4-6,8-9,11,13-14H,3,7,10H2,(H,22,23,25)
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n/an/a 147n/an/an/an/an/an/a



Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)

More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50303639
PNG
(CHEMBL571626 | N-(4-(2-(4-(1H-1,2,3-Triazol-1-yl)p...)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1ccnc(Nc2ccc(cc2)-n2ccnn2)n1
Show InChI InChI=1S/C19H17N7O2S/c1-29(27,28)24-16-4-2-14(3-5-16)18-10-11-20-19(23-18)22-15-6-8-17(9-7-15)26-13-12-21-25-26/h2-13,24H,1H3,(H,20,22,23)
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n/an/a 210n/an/an/an/an/an/a



Eberhard Karls Universit£t T£bingen

Curated by ChEMBL


Assay Description
Inhibition of JNK3-mediated c-jun phosphorylation in rat INS1 cells


J Med Chem 58: 72-95 (2015)

More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50059654
PNG
(CHEMBL2144409)
Show SMILES Cc1ccc(cn1)-c1ncn(n1)-c1ccc(Nc2nccc(n2)-c2cccc(c2)N2CCOCC2)cc1
Show InChI InChI=1S/C28H26N8O/c1-20-5-6-22(18-30-20)27-31-19-36(34-27)24-9-7-23(8-10-24)32-28-29-12-11-26(33-28)21-3-2-4-25(17-21)35-13-15-37-16-14-35/h2-12,17-19H,13-16H2,1H3,(H,29,32,33)
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n/an/a 216n/an/an/an/an/an/a



Eberhard Karls Universit£t T£bingen

Curated by ChEMBL


Assay Description
Inhibition of JNK3-mediated c-jun phosphorylation in rat INS1 cells


J Med Chem 58: 72-95 (2015)

More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50169966
PNG
((2Z)-1,3-benzothiazol-2(3H)-ylidene(2-chloropyrimi...)
Show SMILES Clc1nccc(n1)C(C#N)c1nc2ccccc2s1
Show InChI InChI=1S/C13H7ClN4S/c14-13-16-6-5-9(18-13)8(7-15)12-17-10-3-1-2-4-11(10)19-12/h1-6,8H
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Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)

More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50170001
PNG
(CHEMBL364637 | [3H-Benzothiazol-(2Z)-ylidene]-[2-(...)
Show SMILES N#CC(c1nc2ccccc2s1)c1ccnc(NCCc2ccccn2)n1
Show InChI InChI=1S/C20H16N6S/c21-13-15(19-25-17-6-1-2-7-18(17)27-19)16-9-12-24-20(26-16)23-11-8-14-5-3-4-10-22-14/h1-7,9-10,12,15H,8,11H2,(H,23,24,26)
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Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)

More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50169965
PNG
(CHEMBL363253 | [3H-Benzothiazol-(2Z)-ylidene]-{2-[...)
Show SMILES Fc1ccccc1CCNc1nccc(n1)C(C#N)c1nc2ccccc2s1
Show InChI InChI=1S/C21H16FN5S/c22-16-6-2-1-5-14(16)9-11-24-21-25-12-10-17(27-21)15(13-23)20-26-18-7-3-4-8-19(18)28-20/h1-8,10,12,15H,9,11H2,(H,24,25,27)
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n/an/a 273n/an/an/an/an/an/a



Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)

More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50340599
PNG
(7-(1-methyl-1H-pyrazol-4-yl)-N-(4-(3-morpholino-1H...)
Show SMILES Cn1cc(cn1)-c1ccc2cnc(Nc3ccc(cc3)-n3cnc(n3)N3CCOCC3)nc2c1
Show InChI InChI=1S/C24H23N9O/c1-31-15-19(14-27-31)17-2-3-18-13-25-23(29-22(18)12-17)28-20-4-6-21(7-5-20)33-16-26-24(30-33)32-8-10-34-11-9-32/h2-7,12-16H,8-11H2,1H3,(H,25,28,29)
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Eberhard Karls Universit£t T£bingen

Curated by ChEMBL


Assay Description
Inhibition of JNK3-mediated c-jun phosphorylation in rat INS1 cells


J Med Chem 58: 72-95 (2015)

More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50169977
PNG
(CHEMBL190742 | [3H-Benzothiazol-(2Z)-ylidene]-{2-[...)
Show SMILES N#CC(c1nc2ccccc2s1)c1ccnc(NCc2cccnc2)n1
Show InChI InChI=1S/C19H14N6S/c20-10-14(18-24-16-5-1-2-6-17(16)26-18)15-7-9-22-19(25-15)23-12-13-4-3-8-21-11-13/h1-9,11,14H,12H2,(H,22,23,25)
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Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)

More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50169994
PNG
(CHEMBL189852 | [3H-Benzothiazol-(2Z)-ylidene]-{2-[...)
Show SMILES N#CC(c1nc2ccccc2s1)c1ccnc(NCc2ccncc2)n1
Show InChI InChI=1S/C19H14N6S/c20-11-14(18-24-16-3-1-2-4-17(16)26-18)15-7-10-22-19(25-15)23-12-13-5-8-21-9-6-13/h1-10,14H,12H2,(H,22,23,25)
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Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)

More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50170014
PNG
((2Z)-1,3-benzothiazol-2(3H)-ylidene(6-bromo-2-chlo...)
Show SMILES Clc1nc(Br)cc(n1)C(C#N)c1nc2ccccc2s1
Show InChI InChI=1S/C13H6BrClN4S/c14-11-5-9(18-13(15)19-11)7(6-16)12-17-8-3-1-2-4-10(8)20-12/h1-5,7H
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Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)

More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50169967
PNG
(CHEMBL189223 | [3H-Benzothiazol-(2Z)-ylidene]-[2-(...)
Show SMILES N#CC(c1nc2ccccc2s1)c1ccnc(NCCn2cncn2)n1
Show InChI InChI=1S/C17H14N8S/c18-9-12(16-23-14-3-1-2-4-15(14)26-16)13-5-6-20-17(24-13)21-7-8-25-11-19-10-22-25/h1-6,10-12H,7-8H2,(H,20,21,24)
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Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)

More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50169976
PNG
(CHEMBL191376 | [3H-Benzothiazol-(2Z)-ylidene]-[2-(...)
Show SMILES N#CC(c1nc2ccccc2s1)c1ccnc(NCCCN2CCOCC2)n1
Show InChI InChI=1S/C20H22N6OS/c21-14-15(19-24-17-4-1-2-5-18(17)28-19)16-6-8-23-20(25-16)22-7-3-9-26-10-12-27-13-11-26/h1-2,4-6,8,15H,3,7,9-13H2,(H,22,23,25)
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Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)

More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50169978
PNG
(CHEMBL365963 | [3H-Benzothiazol-(2Z)-ylidene]-[2-(...)
Show SMILES N#CC(c1nc2ccccc2s1)c1ccnc(NCCn2ccc3ccccc23)n1
Show InChI InChI=1S/C23H18N6S/c24-15-17(22-27-19-6-2-4-8-21(19)30-22)18-9-11-25-23(28-18)26-12-14-29-13-10-16-5-1-3-7-20(16)29/h1-11,13,17H,12,14H2,(H,25,26,28)
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Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)

More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50169983
PNG
(CHEMBL424815 | [3H-Benzothiazol-(2Z)-ylidene]-{2-[...)
Show SMILES CN1CCN(CCCNc2nccc(n2)C(C#N)c2nc3ccccc3s2)CC1
Show InChI InChI=1S/C21H25N7S/c1-27-11-13-28(14-12-27)10-4-8-23-21-24-9-7-17(26-21)16(15-22)20-25-18-5-2-3-6-19(18)29-20/h2-3,5-7,9,16H,4,8,10-14H2,1H3,(H,23,24,26)
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n/an/a 473n/an/an/an/an/an/a



Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)

More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50169972
PNG
((2Z)-1,3-benzothiazol-2(3H)-ylidene(2-hydrazinopyr...)
Show SMILES NNc1nccc(n1)C(C#N)c1nc2ccccc2s1
Show InChI InChI=1S/C13H10N6S/c14-7-8(9-5-6-16-13(18-9)19-15)12-17-10-3-1-2-4-11(10)20-12/h1-6,8H,15H2,(H,16,18,19)
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n/an/a 500n/an/an/an/an/an/a



Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)

More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50170016
PNG
(CHEMBL190597 | [3H-Benzothiazol-(2Z)-ylidene]-[2-(...)
Show SMILES OCCNc1nccc(n1)C(C#N)c1nc2ccccc2s1
Show InChI InChI=1S/C15H13N5OS/c16-9-10(11-5-6-17-15(20-11)18-7-8-21)14-19-12-3-1-2-4-13(12)22-14/h1-6,10,21H,7-8H2,(H,17,18,20)
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n/an/a 510n/an/an/an/an/an/a



Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)

More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50169968
PNG
(CHEMBL370889 | [3H-Benzothiazol-(2Z)-ylidene]-[2-(...)
Show SMILES N#CC(c1nc2ccccc2s1)c1ccnc(NCCCn2cccn2)n1
Show InChI InChI=1S/C19H17N7S/c20-13-14(18-24-16-5-1-2-6-17(16)27-18)15-7-10-22-19(25-15)21-8-3-11-26-12-4-9-23-26/h1-2,4-7,9-10,12,14H,3,8,11H2,(H,21,22,25)
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n/an/a 583n/an/an/an/an/an/a



Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)

More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50170006
PNG
(CHEMBL190250 | [3H-Benzothiazol-(2Z)-ylidene]-{2-[...)
Show SMILES [O-][N+](=O)c1ccc(CCNc2nccc(n2)C(=C=[N-])c2[nH+]c3ccccc3s2)cc1
Show InChI InChI=1S/C21H15N6O2S/c22-13-16(20-25-18-3-1-2-4-19(18)30-20)17-10-12-24-21(26-17)23-11-9-14-5-7-15(8-6-14)27(28)29/h1-8,10,12H,9,11H2,(H,23,24,26)/q-1/p+1
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n/an/a 600n/an/an/an/an/an/a



Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)

More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50169960
PNG
(CHEMBL364940 | [3H-Benzothiazol-(2Z)-ylidene]-{2-[...)
Show SMILES N#CC(c1nc2ccccc2s1)c1ccnc(NCc2ccccn2)n1
Show InChI InChI=1S/C19H14N6S/c20-11-14(18-24-16-6-1-2-7-17(16)26-18)15-8-10-22-19(25-15)23-12-13-5-3-4-9-21-13/h1-10,14H,12H2,(H,22,23,25)
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n/an/a 650n/an/an/an/an/an/a



Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)

More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50170013
PNG
(CHEMBL191465 | [3H-Benzothiazol-(2Z)-ylidene]-[2-(...)
Show SMILES OCCCNc1nccc(n1)C(C#N)c1nc2ccccc2s1
Show InChI InChI=1S/C16H15N5OS/c17-10-11(15-20-13-4-1-2-5-14(13)23-15)12-6-8-19-16(21-12)18-7-3-9-22/h1-2,4-6,8,11,22H,3,7,9H2,(H,18,19,21)
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n/an/a 660n/an/an/an/an/an/a



Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)

More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50169979
PNG
(CHEMBL191021 | [2-(3-Amino-propylamino)-pyrimidin-...)
Show SMILES NCCCNc1nccc(n1)C(C#N)c1nc2ccccc2s1
Show InChI InChI=1S/C16H16N6S/c17-7-3-8-19-16-20-9-6-12(22-16)11(10-18)15-21-13-4-1-2-5-14(13)23-15/h1-2,4-6,9,11H,3,7-8,17H2,(H,19,20,22)
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n/an/a 707n/an/an/an/an/an/a



Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)

More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50169963
PNG
(CHEMBL370899 | [3H-Benzothiazol-(2Z)-ylidene]-[2-(...)
Show SMILES N#CC(c1nc2ccccc2s1)c1ccnc(NCCN2CCOCC2)n1
Show InChI InChI=1S/C19H20N6OS/c20-13-14(18-23-16-3-1-2-4-17(16)27-18)15-5-6-21-19(24-15)22-7-8-25-9-11-26-12-10-25/h1-6,14H,7-12H2,(H,21,22,24)
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n/an/a 760n/an/an/an/an/an/a



Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)

More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50170012
PNG
(CHEMBL191269 | [3H-Benzothiazol-(2Z)-ylidene]-[2-(...)
Show SMILES COCCNc1nccc(n1)C(C#N)c1nc2ccccc2s1
Show InChI InChI=1S/C16H15N5OS/c1-22-9-8-19-16-18-7-6-12(21-16)11(10-17)15-20-13-4-2-3-5-14(13)23-15/h2-7,11H,8-9H2,1H3,(H,18,19,21)
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n/an/a 820n/an/an/an/an/an/a



Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)

More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50169970
PNG
((2Z)-1,3-benzothiazol-2(3H)-ylidene[2-(methylamino...)
Show SMILES CNc1nccc(n1)C(C#N)c1nc2ccccc2s1
Show InChI InChI=1S/C14H11N5S/c1-16-14-17-7-6-10(19-14)9(8-15)13-18-11-4-2-3-5-12(11)20-13/h2-7,9H,1H3,(H,16,17,19)
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n/an/a 950n/an/an/an/an/an/a



Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)

More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50169982
PNG
((2Z)-(2-chloropyrimidin-4-yl)[5-(trifluoromethyl)-...)
Show SMILES FC(F)(F)c1ccc2sc(nc2c1)C(C#N)c1ccnc(Cl)n1
Show InChI InChI=1S/C14H6ClF3N4S/c15-13-20-4-3-9(22-13)8(6-19)12-21-10-5-7(14(16,17)18)1-2-11(10)23-12/h1-5,8H
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n/an/a 993n/an/an/an/an/an/a



Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)

More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM92522
PNG
(Aminopyrazole inhibitor, 3451)
Show SMILES COc1cc(NC(=O)c2cccc(c2)-n2cc(NC(=O)Nc3ccccc3)cn2)cc(OC)c1OC
Show InChI InChI=1S/C26H25N5O5/c1-34-22-13-19(14-23(35-2)24(22)36-3)28-25(32)17-8-7-11-21(12-17)31-16-20(15-27-31)30-26(33)29-18-9-5-4-6-10-18/h4-16H,1-3H3,(H,28,32)(H2,29,30,33)
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n/an/a 1.20E+3n/an/an/an/an/an/a



Eberhard Karls Universit£t T£bingen

Curated by ChEMBL


Assay Description
Inhibition of JNK3-mediated c-jun phosphorylation in rat INS1 cells


J Med Chem 58: 72-95 (2015)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM92524
PNG
(Aminopyrazole inhibitor, 3576)
Show SMILES COc1cc(NC(=O)c2cccc(c2)-n2cc(NC(=O)Nc3cccc(C)c3)cn2)cc(OC)c1OC
Show InChI InChI=1S/C27H27N5O5/c1-17-7-5-9-19(11-17)30-27(34)31-21-15-28-32(16-21)22-10-6-8-18(12-22)26(33)29-20-13-23(35-2)25(37-4)24(14-20)36-3/h5-16H,1-4H3,(H,29,33)(H2,30,31,34)
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n/an/a 1.30E+3n/an/an/an/an/an/a



Eberhard Karls Universit£t T£bingen

Curated by ChEMBL


Assay Description
Inhibition of JNK3-mediated c-jun phosphorylation in rat INS1 cells


J Med Chem 58: 72-95 (2015)

More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50169993
PNG
(CHEMBL425553 | [3H-Benzothiazol-(2Z)-ylidene]-[2-(...)
Show SMILES CN(C)CCNc1nccc(n1)C(C#N)c1nc2ccccc2s1
Show InChI InChI=1S/C17H18N6S/c1-23(2)10-9-20-17-19-8-7-13(22-17)12(11-18)16-21-14-5-3-4-6-15(14)24-16/h3-8,12H,9-10H2,1-2H3,(H,19,20,22)
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n/an/a 1.30E+3n/an/an/an/an/an/a



Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)

More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50170011
PNG
(CHEMBL370960 | [3H-Benzothiazol-(2Z)-ylidene]-{2-[...)
Show SMILES CNCCCN(C)c1nccc(n1)C(C#N)c1nc2ccccc2s1
Show InChI InChI=1S/C18H20N6S/c1-20-9-5-11-24(2)18-21-10-8-14(23-18)13(12-19)17-22-15-6-3-4-7-16(15)25-17/h3-4,6-8,10,13,20H,5,9,11H2,1-2H3
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n/an/a 1.32E+3n/an/an/an/an/an/a



Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)

More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50170015
PNG
(CHEMBL191543 | N-[3-(4-{[3H-Benzothiazol-(2Z)-ylid...)
Show SMILES CCCN(CCCNc1nccc(n1)C(C#N)c1nc2ccccc2s1)C(=O)CC
Show InChI InChI=1S/C22H26N6OS/c1-3-13-28(20(29)4-2)14-7-11-24-22-25-12-10-17(27-22)16(15-23)21-26-18-8-5-6-9-19(18)30-21/h5-6,8-10,12,16H,3-4,7,11,13-14H2,1-2H3,(H,24,25,27)
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n/an/a 1.34E+3n/an/an/an/an/an/a



Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)

More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50169961
PNG
(CHEMBL363556 | [2-(2-Amino-ethylamino)-pyrimidin-4...)
Show SMILES NCCNc1nccc(n1)C(C#N)c1nc2ccccc2s1
Show InChI InChI=1S/C15H14N6S/c16-6-8-19-15-18-7-5-11(21-15)10(9-17)14-20-12-3-1-2-4-13(12)22-14/h1-5,7,10H,6,8,16H2,(H,18,19,21)
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n/an/a 1.49E+3n/an/an/an/an/an/a



Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)

More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50170000
PNG
(CHEMBL190859 | [3H-Benzothiazol-(2Z)-ylidene]-[2-(...)
Show SMILES CN(C)CCCNc1nccc(n1)C(C#N)c1nc2ccccc2s1
Show InChI InChI=1S/C18H20N6S/c1-24(2)11-5-9-20-18-21-10-8-14(23-18)13(12-19)17-22-15-6-3-4-7-16(15)25-17/h3-4,6-8,10,13H,5,9,11H2,1-2H3,(H,20,21,23)
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n/an/a 1.64E+3n/an/an/an/an/an/a



Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)

More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50170005
PNG
(CHEMBL189421 | [3H-Benzothiazol-(2Z)-ylidene]-{2-[...)
Show SMILES Fc1cccc(CCNc2nccc(n2)C(C#N)c2nc3ccccc3s2)c1
Show InChI InChI=1S/C21H16FN5S/c22-15-5-3-4-14(12-15)8-10-24-21-25-11-9-17(27-21)16(13-23)20-26-18-6-1-2-7-19(18)28-20/h1-7,9,11-12,16H,8,10H2,(H,24,25,27)
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n/an/a 1.81E+3n/an/an/an/an/an/a



Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)

More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50059659
PNG
(CHEMBL3393604)
Show SMILES COc1ccc2OC(COc2c1)C(=O)NC(=O)N(CC(C)C)CC(=O)NCCCCCCNC(=O)c1ccc(cc1)-c1n[nH]c2ccccc12
Show InChI InChI=1/C37H44N6O7/c1-24(2)21-43(37(47)40-36(46)32-23-49-31-20-27(48-3)16-17-30(31)50-32)22-33(44)38-18-8-4-5-9-19-39-35(45)26-14-12-25(13-15-26)34-28-10-6-7-11-29(28)41-42-34/h6-7,10-17,20,24,32H,4-5,8-9,18-19,21-23H2,1-3H3,(H,38,44)(H,39,45)(H,41,42)(H,40,46,47)
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n/an/a 2.80E+3n/an/an/an/an/an/a



Eberhard Karls Universit£t T£bingen

Curated by ChEMBL


Assay Description
Inhibition of JNK3-mediated c-jun phosphorylation in rat INS1 cells


J Med Chem 58: 72-95 (2015)

More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50169975
PNG
(CHEMBL188499 | [3H-Benzothiazol-(2Z)-ylidene]-(2-m...)
Show SMILES N#CC(c1nc2ccccc2s1)c1ccnc(n1)N1CCOCC1
Show InChI InChI=1S/C17H15N5OS/c18-11-12(16-20-14-3-1-2-4-15(14)24-16)13-5-6-19-17(21-13)22-7-9-23-10-8-22/h1-6,12H,7-10H2
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n/an/a 2.90E+3n/an/an/an/an/an/a



Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)

More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50169995
PNG
(2-(2-(4-methoxyphenethylamino)pyrimidin-4-yl)-2-(b...)
Show SMILES COc1ccc(CCNc2nccc(n2)C(C#N)c2nc3ccccc3s2)cc1
Show InChI InChI=1S/C22H19N5OS/c1-28-16-8-6-15(7-9-16)10-12-24-22-25-13-11-18(27-22)17(14-23)21-26-19-4-2-3-5-20(19)29-21/h2-9,11,13,17H,10,12H2,1H3,(H,24,25,27)
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n/an/a 3.08E+3n/an/an/an/an/an/a



Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)

More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50170009
PNG
(CHEMBL373086 | [3H-Benzothiazol-(2Z)-ylidene]-{2-[...)
Show SMILES Oc1ccc(CCNc2nccc(n2)C(C#N)c2nc3ccccc3s2)cc1
Show InChI InChI=1S/C21H17N5OS/c22-13-16(20-25-18-3-1-2-4-19(18)28-20)17-10-12-24-21(26-17)23-11-9-14-5-7-15(27)8-6-14/h1-8,10,12,16,27H,9,11H2,(H,23,24,26)
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n/an/a 3.50E+3n/an/an/an/an/an/a



Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)

More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50169996
PNG
(CHEMBL365191 | [3H-Benzothiazol-(2Z)-ylidene]-[2-(...)
Show SMILES N#CC(c1nc2ccccc2s1)c1ccnc(NCCN2CCCCC2)n1
Show InChI InChI=1S/C20H22N6S/c21-14-15(19-24-17-6-2-3-7-18(17)27-19)16-8-9-22-20(25-16)23-10-13-26-11-4-1-5-12-26/h2-3,6-9,15H,1,4-5,10-13H2,(H,22,23,25)
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n/an/a 3.74E+3n/an/an/an/an/an/a



Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)

More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50433094
PNG
(CHEMBL2376915)
Show SMILES Clc1ccccc1Nc1ccc2n(ncc2c1)-c1cccc(c1)C(=O)NCCN1CCOCC1
Show InChI InChI=1S/C26H26ClN5O2/c27-23-6-1-2-7-24(23)30-21-8-9-25-20(16-21)18-29-32(25)22-5-3-4-19(17-22)26(33)28-10-11-31-12-14-34-15-13-31/h1-9,16-18,30H,10-15H2,(H,28,33)
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n/an/a 4.10E+3n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of JNK3-mediated c-Jun phosphorylation in rat INS-1 cells after 3 hrs by ELISA


Bioorg Med Chem Lett 23: 2683-7 (2013)

More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50170003
PNG
((2Z)-(2-chloropyrimidin-4-yl)(3-methyl-1,3-benzoth...)
Show SMILES CN1\C(Sc2ccccc12)=C(\C#N)c1ccnc(Cl)n1
Show InChI InChI=1S/C14H9ClN4S/c1-19-11-4-2-3-5-12(11)20-13(19)9(8-16)10-6-7-17-14(15)18-10/h2-7H,1H3/b13-9+
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n/an/a>5.00E+3n/an/an/an/an/an/a



Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)

More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50169997
PNG
((2Z)-1,3-benzothiazol-2(3H)-ylidene(2-chloro-6-met...)
Show SMILES Cc1cc(nc(Cl)n1)C(C#N)c1nc2ccccc2s1
Show InChI InChI=1S/C14H9ClN4S/c1-8-6-11(19-14(15)17-8)9(7-16)13-18-10-4-2-3-5-12(10)20-13/h2-6,9H,1H3
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n/an/a>5.00E+3n/an/an/an/an/an/a



Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)

More data for this
Ligand-Target Pair
c-Jun N-terminal kinase 3


(Rattus norvegicus)
BDBM50169988
PNG
(CHEMBL362932 | [3H-Benzothiazol-(2Z)-ylidene]-{2-[...)
Show SMILES Clc1ccc(CCNc2nccc(n2)C(C#N)c2nc3ccccc3s2)cc1Cl
Show InChI InChI=1S/C21H15Cl2N5S/c22-15-6-5-13(11-16(15)23)7-9-25-21-26-10-8-17(28-21)14(12-24)20-27-18-3-1-2-4-19(18)29-20/h1-6,8,10-11,14H,7,9H2,(H,25,26,28)
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n/an/a>5.00E+3n/an/an/an/an/an/a



Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat c-Jun N-terminal kinase 3


J Med Chem 48: 4596-607 (2005)

More data for this
Ligand-Target Pair
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