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Found 102 hits Enz. Inhib. hit(s) with Target = 'cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A' AND taxid = 10090   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Mus musculus)
BDBM50390149
PNG
(CHEMBL2069680)
Show SMILES COC(C(=O)N\N=C\c1cc(OC)c(Br)c(OC)c1)c1ccc(cc1)N1CCOCC1
Show InChI InChI=1S/C22H26BrN3O5/c1-28-18-12-15(13-19(29-2)20(18)23)14-24-25-22(27)21(30-3)16-4-6-17(7-5-16)26-8-10-31-11-9-26/h4-7,12-14,21H,8-11H2,1-3H3,(H,25,27)/b24-14+
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n/an/a 0.640n/an/an/an/an/an/a



Omeros Corp.

Curated by ChEMBL


Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Mus musculus)
BDBM50390148
PNG
(CHEMBL2069681)
Show SMILES COC(C(=O)N\N=C\c1cc(OC)c(Br)c(OC)c1)c1ccc(cc1)N1CCCS1(=O)=O
Show InChI InChI=1S/C21H24BrN3O6S/c1-29-17-11-14(12-18(30-2)19(17)22)13-23-24-21(26)20(31-3)15-5-7-16(8-6-15)25-9-4-10-32(25,27)28/h5-8,11-13,20H,4,9-10H2,1-3H3,(H,24,26)/b23-13+
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n/an/a 0.700n/an/an/an/an/an/a



Omeros Corp.

Curated by ChEMBL


Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Mus musculus)
BDBM50390137
PNG
(CHEMBL2069694)
Show SMILES COC(C(=O)N\N=C\c1cc(OC)c(Br)c(OC)c1)c1ccc(cc1)-n1cccn1
Show InChI InChI=1S/C21H21BrN4O4/c1-28-17-11-14(12-18(29-2)19(17)22)13-23-25-21(27)20(30-3)15-5-7-16(8-6-15)26-10-4-9-24-26/h4-13,20H,1-3H3,(H,25,27)/b23-13+
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n/an/a 0.800n/an/an/an/an/an/a



Omeros Corp.

Curated by ChEMBL


Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Mus musculus)
BDBM50048260
PNG
(CHEMBL3315045)
Show SMILES Cc1cnc2c(cn(C)c2c1)-c1ccc(Oc2ncccc2-c2ccncc2)cc1
Show InChI InChI=1S/C25H20N4O/c1-17-14-23-24(28-15-17)22(16-29(23)2)18-5-7-20(8-6-18)30-25-21(4-3-11-27-25)19-9-12-26-13-10-19/h3-16H,1-2H3
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n/an/a 1.20n/an/an/an/an/an/a



Glenmark Pharmaceuticals Ltd

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant GST-tagged PDE10A using [3H]-cAMP as substrate after 30 mins by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Mus musculus)
BDBM50390137
PNG
(CHEMBL2069694)
Show SMILES COC(C(=O)N\N=C\c1cc(OC)c(Br)c(OC)c1)c1ccc(cc1)-n1cccn1
Show InChI InChI=1S/C21H21BrN4O4/c1-28-17-11-14(12-18(29-2)19(17)22)13-23-25-21(27)20(30-3)15-5-7-16(8-6-15)26-10-4-9-24-26/h4-13,20H,1-3H3,(H,25,27)/b23-13+
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n/an/a 1.30n/an/an/an/an/an/a



Omeros Corp.

Curated by ChEMBL


Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Mus musculus)
BDBM50390159
PNG
(CHEMBL2069696)
Show SMILES COc1cc(\C=N\NC(=O)C(OC(C)C)c2ccc(cc2)N2CCOCC2)cc(OC)c1Br
Show InChI InChI=1S/C24H30BrN3O5/c1-16(2)33-23(18-5-7-19(8-6-18)28-9-11-32-12-10-28)24(29)27-26-15-17-13-20(30-3)22(25)21(14-17)31-4/h5-8,13-16,23H,9-12H2,1-4H3,(H,27,29)/b26-15+
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n/an/a 1.70n/an/an/an/an/an/a



Omeros Corp.

Curated by ChEMBL


Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Mus musculus)
BDBM50390138
PNG
(CHEMBL2069693)
Show SMILES COC(C(=O)N\N=C\c1cc(OC)c(Br)c(OC)c1)c1ccc(cc1)-n1ccnn1
Show InChI InChI=1S/C20H20BrN5O4/c1-28-16-10-13(11-17(29-2)18(16)21)12-23-24-20(27)19(30-3)14-4-6-15(7-5-14)26-9-8-22-25-26/h4-12,19H,1-3H3,(H,24,27)/b23-12+
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n/an/a 1.70n/an/an/an/an/an/a



Omeros Corp.

Curated by ChEMBL


Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Mus musculus)
BDBM50390136
PNG
(CHEMBL2069695)
Show SMILES CCOC(C(=O)N\N=C\c1cc(OC)c(Br)c(OC)c1)c1ccc(cc1)N1CCOCC1
Show InChI InChI=1S/C23H28BrN3O5/c1-4-32-22(17-5-7-18(8-6-17)27-9-11-31-12-10-27)23(28)26-25-15-16-13-19(29-2)21(24)20(14-16)30-3/h5-8,13-15,22H,4,9-12H2,1-3H3,(H,26,28)/b25-15+
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n/an/a 1.90n/an/an/an/an/an/a



Omeros Corp.

Curated by ChEMBL


Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Mus musculus)
BDBM50390162
PNG
(CHEMBL2069687)
Show SMILES COC(C(=O)N\N=C\c1cc(OC)c(Br)c(OC)c1)c1cccc2ncccc12
Show InChI InChI=1S/C21H20BrN3O4/c1-27-17-10-13(11-18(28-2)19(17)22)12-24-25-21(26)20(29-3)15-6-4-8-16-14(15)7-5-9-23-16/h4-12,20H,1-3H3,(H,25,26)/b24-12+
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n/an/a 2.20n/an/an/an/an/an/a



Omeros Corp.

Curated by ChEMBL


Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Mus musculus)
BDBM50390143
PNG
(CHEMBL2069686)
Show SMILES COC(C(=O)N\N=C\c1cc(OC)c(Br)c(OC)c1)c1cnc2ccccc2c1
Show InChI InChI=1S/C21H20BrN3O4/c1-27-17-8-13(9-18(28-2)19(17)22)11-24-25-21(26)20(29-3)15-10-14-6-4-5-7-16(14)23-12-15/h4-12,20H,1-3H3,(H,25,26)/b24-11+
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n/an/a 2.30n/an/an/an/an/an/a



Omeros Corp.

Curated by ChEMBL


Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Mus musculus)
BDBM50390158
PNG
(CHEMBL2069697)
Show SMILES CCOC(C(=O)N\N=C\c1cc(OC)c(Br)c(OC)c1)c1ccc(cc1)-n1cccn1
Show InChI InChI=1S/C22H23BrN4O4/c1-4-31-21(16-6-8-17(9-7-16)27-11-5-10-25-27)22(28)26-24-14-15-12-18(29-2)20(23)19(13-15)30-3/h5-14,21H,4H2,1-3H3,(H,26,28)/b24-14+
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n/an/a 2.5n/an/an/an/an/an/a



Omeros Corp.

Curated by ChEMBL


Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Mus musculus)
BDBM50130841
PNG
(CHEMBL3634745)
Show SMILES Fc1ccc(cc1)-c1[nH]c(=O)ccc1-c1ccc(OCc2ccc3ccccc3n2)cc1
Show InChI InChI=1S/C27H19FN2O2/c28-21-10-5-20(6-11-21)27-24(15-16-26(31)30-27)18-8-13-23(14-9-18)32-17-22-12-7-19-3-1-2-4-25(19)29-22/h1-16H,17H2,(H,30,31)
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n/an/a 2.60n/an/an/an/an/an/a



Glenmark Research Centre

Curated by ChEMBL


Assay Description
Inhibition of mouse PDE10A using [3H]cAMP/cAMP as substrate assessed as hydrolysis of [3H]cAMP to [3H]AMP after 30 mins by scintillation proximity as...


J Med Chem 58: 8292-308 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Mus musculus)
BDBM50390149
PNG
(CHEMBL2069680)
Show SMILES COC(C(=O)N\N=C\c1cc(OC)c(Br)c(OC)c1)c1ccc(cc1)N1CCOCC1
Show InChI InChI=1S/C22H26BrN3O5/c1-28-18-12-15(13-19(29-2)20(18)23)14-24-25-22(27)21(30-3)16-4-6-17(7-5-16)26-8-10-31-11-9-26/h4-7,12-14,21H,8-11H2,1-3H3,(H,25,27)/b24-14+
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n/an/a 3.20n/an/an/an/an/an/a



Omeros Corp.

Curated by ChEMBL


Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Mus musculus)
BDBM50390145
PNG
(CHEMBL2069684)
Show SMILES COC(C(=O)N\N=C\c1cc(OC)c(Br)c(OC)c1)c1ccc(nc1)N1CCOCC1
Show InChI InChI=1S/C21H25BrN4O5/c1-28-16-10-14(11-17(29-2)19(16)22)12-24-25-21(27)20(30-3)15-4-5-18(23-13-15)26-6-8-31-9-7-26/h4-5,10-13,20H,6-9H2,1-3H3,(H,25,27)/b24-12+
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n/an/a 3.30n/an/an/an/an/an/a



Omeros Corp.

Curated by ChEMBL


Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Mus musculus)
BDBM50390144
PNG
(CHEMBL2069685)
Show SMILES COC(C(=O)N\N=C\c1cc(OC)c(Br)c(OC)c1)c1ccc(nc1)N1CCCCC1
Show InChI InChI=1S/C22H27BrN4O4/c1-29-17-11-15(12-18(30-2)20(17)23)13-25-26-22(28)21(31-3)16-7-8-19(24-14-16)27-9-5-4-6-10-27/h7-8,11-14,21H,4-6,9-10H2,1-3H3,(H,26,28)/b25-13+
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n/an/a 3.40n/an/an/an/an/an/a



Omeros Corp.

Curated by ChEMBL


Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Mus musculus)
BDBM50390160
PNG
(CHEMBL2069692)
Show SMILES COC(C(=O)N\N=C\c1cc(OC)c(Br)c(OC)c1)c1ccc(cc1)-n1cnnn1
Show InChI InChI=1S/C19H19BrN6O4/c1-28-15-8-12(9-16(29-2)17(15)20)10-21-23-19(27)18(30-3)13-4-6-14(7-5-13)26-11-22-24-25-26/h4-11,18H,1-3H3,(H,23,27)/b21-10+
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n/an/a 3.60n/an/an/an/an/an/a



Omeros Corp.

Curated by ChEMBL


Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Mus musculus)
BDBM50390142
PNG
(CHEMBL2069688)
Show SMILES COC(C(=O)N\N=C\c1cc(OC)c(Br)c(OC)c1)c1ccnc2ccccc12
Show InChI InChI=1S/C21H20BrN3O4/c1-27-17-10-13(11-18(28-2)19(17)22)12-24-25-21(26)20(29-3)15-8-9-23-16-7-5-4-6-14(15)16/h4-12,20H,1-3H3,(H,25,26)/b24-12+
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n/an/a 3.90n/an/an/an/an/an/a



Omeros Corp.

Curated by ChEMBL


Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Mus musculus)
BDBM50048261
PNG
(CHEMBL3315044)
Show SMILES Cn1cc(-c2ccc(Oc3ncccc3-c3ccncc3)cc2)c2ncccc12
Show InChI InChI=1S/C24H18N4O/c1-28-16-21(23-22(28)5-3-12-26-23)17-6-8-19(9-7-17)29-24-20(4-2-13-27-24)18-10-14-25-15-11-18/h2-16H,1H3
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n/an/a 4.10n/an/an/an/an/an/a



Glenmark Pharmaceuticals Ltd

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant GST-tagged PDE10A using [3H]-cAMP as substrate after 30 mins by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Mus musculus)
BDBM50390139
PNG
(CHEMBL2069691)
Show SMILES COC(C(=O)N\N=C\c1cc(OC)c(Br)c(OC)c1)c1ccc(cc1)-n1cncn1
Show InChI InChI=1S/C20H20BrN5O4/c1-28-16-8-13(9-17(29-2)18(16)21)10-23-25-20(27)19(30-3)14-4-6-15(7-5-14)26-12-22-11-24-26/h4-12,19H,1-3H3,(H,25,27)/b23-10+
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n/an/a 4.40n/an/an/an/an/an/a



Omeros Corp.

Curated by ChEMBL


Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Mus musculus)
BDBM50348344
PNG
(CHEMBL1800313)
Show SMILES COc1cc(\C=N\NC(=O)CSc2cc(C)nc3ccccc23)cc(OC)c1Br
Show InChI InChI=1S/C21H20BrN3O3S/c1-13-8-19(15-6-4-5-7-16(15)24-13)29-12-20(26)25-23-11-14-9-17(27-2)21(22)18(10-14)28-3/h4-11H,12H2,1-3H3,(H,25,26)/b23-11+
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n/an/a 4.80n/an/an/an/an/an/a



Omeros Corp.

Curated by ChEMBL


Assay Description
Inhibition of mouse PDE10A assessed as inhibition of hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Mus musculus)
BDBM50390156
PNG
(CHEMBL2069673)
Show SMILES COC(C(=O)N\N=C\c1cc(OC)c(Br)c(OC)c1)c1ccc2OCCOc2c1
Show InChI InChI=1S/C20H21BrN2O6/c1-25-16-8-12(9-17(26-2)18(16)21)11-22-23-20(24)19(27-3)13-4-5-14-15(10-13)29-7-6-28-14/h4-5,8-11,19H,6-7H2,1-3H3,(H,23,24)/b22-11+
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n/an/a 6n/an/an/an/an/an/a



Omeros Corp.

Curated by ChEMBL


Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Mus musculus)
BDBM50390154
PNG
(CHEMBL2069675)
Show SMILES COC(C(=O)N\N=C\c1cc(OC)c(Br)c(OC)c1)c1cccc(c1)N(C)C
Show InChI InChI=1S/C20H24BrN3O4/c1-24(2)15-8-6-7-14(11-15)19(28-5)20(25)23-22-12-13-9-16(26-3)18(21)17(10-13)27-4/h6-12,19H,1-5H3,(H,23,25)/b22-12+
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n/an/a 6.60n/an/an/an/an/an/a



Omeros Corp.

Curated by ChEMBL


Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Mus musculus)
BDBM50048258
PNG
(CHEMBL3315046)
Show SMILES Cn1cc(-c2ccc(Oc3ncccc3-c3ccncc3)cc2)c2ncc(Cl)cc12
Show InChI InChI=1S/C24H17ClN4O/c1-29-15-21(23-22(29)13-18(25)14-28-23)16-4-6-19(7-5-16)30-24-20(3-2-10-27-24)17-8-11-26-12-9-17/h2-15H,1H3
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n/an/a 6.70n/an/an/an/an/an/a



Glenmark Pharmaceuticals Ltd

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant GST-tagged PDE10A using [3H]-cAMP as substrate after 30 mins by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Mus musculus)
BDBM50390153
PNG
(CHEMBL2069676)
Show SMILES COC(C(=O)N\N=C\c1cc(OC)c(Br)c(OC)c1)c1ccc(cc1)N(C)C
Show InChI InChI=1S/C20H24BrN3O4/c1-24(2)15-8-6-14(7-9-15)19(28-5)20(25)23-22-12-13-10-16(26-3)18(21)17(11-13)27-4/h6-12,19H,1-5H3,(H,23,25)/b22-12+
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n/an/a 7n/an/an/an/an/an/a



Omeros Corp.

Curated by ChEMBL


Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Mus musculus)
BDBM50390150
PNG
(CHEMBL2069679)
Show SMILES COC(C(=O)N\N=C\c1cc(OC)c(Br)c(OC)c1)c1ccc(cc1)N1CCCC1
Show InChI InChI=1S/C22H26BrN3O4/c1-28-18-12-15(13-19(29-2)20(18)23)14-24-25-22(27)21(30-3)16-6-8-17(9-7-16)26-10-4-5-11-26/h6-9,12-14,21H,4-5,10-11H2,1-3H3,(H,25,27)/b24-14+
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n/an/a 7.60n/an/an/an/an/an/a



Omeros Corp.

Curated by ChEMBL


Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Mus musculus)
BDBM50348333
PNG
(CHEMBL1800236)
Show SMILES COc1ccc2nc(C)cc(SCC(=O)N\N=C\c3cc(OC)c(OC)c(OC)c3)c2c1
Show InChI InChI=1S/C23H25N3O5S/c1-14-8-21(17-11-16(28-2)6-7-18(17)25-14)32-13-22(27)26-24-12-15-9-19(29-3)23(31-5)20(10-15)30-4/h6-12H,13H2,1-5H3,(H,26,27)/b24-12+
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n/an/a 8n/an/an/an/an/an/a



Omeros Corp.

Curated by ChEMBL


Assay Description
Inhibition of mouse PDE10A assessed as inhibition of hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Mus musculus)
BDBM50390157
PNG
(CHEMBL2069698)
Show SMILES COc1cc(\C=N\NC(=O)C(OC(C)C)c2ccc(cc2)-n2cccn2)cc(OC)c1Br
Show InChI InChI=1S/C23H25BrN4O4/c1-15(2)32-22(17-6-8-18(9-7-17)28-11-5-10-26-28)23(29)27-25-14-16-12-19(30-3)21(24)20(13-16)31-4/h5-15,22H,1-4H3,(H,27,29)/b25-14+
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n/an/a 8.30n/an/an/an/an/an/a



Omeros Corp.

Curated by ChEMBL


Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Mus musculus)
BDBM50390121
PNG
(CHEMBL2069664)
Show SMILES CCOc1cc(\C=N\NC(=O)C(OC)c2ccc3OCCOc3c2)cc(Br)c1OC
Show InChI InChI=1S/C21H23BrN2O6/c1-4-28-18-10-13(9-15(22)20(18)27-3)12-23-24-21(25)19(26-2)14-5-6-16-17(11-14)30-8-7-29-16/h5-6,9-12,19H,4,7-8H2,1-3H3,(H,24,25)/b23-12+
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n/an/a 9n/an/an/an/an/an/a



Omeros Corp.

Curated by ChEMBL


Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Mus musculus)
BDBM50390122
PNG
(CHEMBL2069663)
Show SMILES CCOc1cc(\C=N\NC(=O)C(OC)c2ccc3OCCOc3c2)cc(Cl)c1OC
Show InChI InChI=1S/C21H23ClN2O6/c1-4-28-18-10-13(9-15(22)20(18)27-3)12-23-24-21(25)19(26-2)14-5-6-16-17(11-14)30-8-7-29-16/h5-6,9-12,19H,4,7-8H2,1-3H3,(H,24,25)/b23-12+
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n/an/a 9n/an/an/an/an/an/a



Omeros Corp.

Curated by ChEMBL


Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Mus musculus)
BDBM50390140
PNG
(CHEMBL2069690)
Show SMILES COC(C(=O)N\N=C\c1cc(OC)c(Br)c(OC)c1)c1ccc(cc1)-n1ccnc1
Show InChI InChI=1S/C21H21BrN4O4/c1-28-17-10-14(11-18(29-2)19(17)22)12-24-25-21(27)20(30-3)15-4-6-16(7-5-15)26-9-8-23-13-26/h4-13,20H,1-3H3,(H,25,27)/b24-12+
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n/an/a 10n/an/an/an/an/an/a



Omeros Corp.

Curated by ChEMBL


Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Mus musculus)
BDBM50390155
PNG
(CHEMBL2069674)
Show SMILES COC(C(=O)N\N=C\c1cc(OC)c(Br)c(OC)c1)c1ccc2OCOc2c1
Show InChI InChI=1S/C19H19BrN2O6/c1-24-15-6-11(7-16(25-2)17(15)20)9-21-22-19(23)18(26-3)12-4-5-13-14(8-12)28-10-27-13/h4-9,18H,10H2,1-3H3,(H,22,23)/b21-9+
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n/an/a 10n/an/an/an/an/an/a



Omeros Corp.

Curated by ChEMBL


Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Mus musculus)
BDBM50390151
PNG
(CHEMBL2069678)
Show SMILES COC(C(=O)N\N=C\c1cc(OC)c(Br)c(OC)c1)c1cccc(c1)N1CCCC1
Show InChI InChI=1S/C22H26BrN3O4/c1-28-18-11-15(12-19(29-2)20(18)23)14-24-25-22(27)21(30-3)16-7-6-8-17(13-16)26-9-4-5-10-26/h6-8,11-14,21H,4-5,9-10H2,1-3H3,(H,25,27)/b24-14+
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n/an/a 10n/an/an/an/an/an/a



Omeros Corp.

Curated by ChEMBL


Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Mus musculus)
BDBM50348350
PNG
(CHEMBL1800307)
Show SMILES COc1cc(\C=N\NC(=O)CSc2cc(C)nc3ccccc23)cc(OC)c1OC
Show InChI InChI=1S/C22H23N3O4S/c1-14-9-20(16-7-5-6-8-17(16)24-14)30-13-21(26)25-23-12-15-10-18(27-2)22(29-4)19(11-15)28-3/h5-12H,13H2,1-4H3,(H,25,26)/b23-12+
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n/an/a 10n/an/an/an/an/an/a



Omeros Corp.

Curated by ChEMBL


Assay Description
Inhibition of mouse PDE10A assessed as inhibition of hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Mus musculus)
BDBM50390147
PNG
(CHEMBL2069682)
Show SMILES COC(C(=O)N\N=C\c1cc(OC)c(Br)c(OC)c1)c1ccc(cc1)N1CCS(=O)(=O)CC1
Show InChI InChI=1S/C22H26BrN3O6S/c1-30-18-12-15(13-19(31-2)20(18)23)14-24-25-22(27)21(32-3)16-4-6-17(7-5-16)26-8-10-33(28,29)11-9-26/h4-7,12-14,21H,8-11H2,1-3H3,(H,25,27)/b24-14+
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n/an/a 10n/an/an/an/an/an/a



Omeros Corp.

Curated by ChEMBL


Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Mus musculus)
BDBM50348349
PNG
(CHEMBL1800308)
Show SMILES COc1cc(\C=N\NC(=O)CSc2cc(C)nc3ccccc23)cc(C#N)c1OC
Show InChI InChI=1S/C22H20N4O3S/c1-14-8-20(17-6-4-5-7-18(17)25-14)30-13-21(27)26-24-12-15-9-16(11-23)22(29-3)19(10-15)28-2/h4-10,12H,13H2,1-3H3,(H,26,27)/b24-12+
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n/an/a 11n/an/an/an/an/an/a



Omeros Corp.

Curated by ChEMBL


Assay Description
Inhibition of mouse PDE10A assessed as inhibition of hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Mus musculus)
BDBM50048262
PNG
(CHEMBL3315042)
Show SMILES Cn1cc(-c2ccc(Oc3nccnc3-c3ccncc3)cc2)c2ncccc12
Show InChI InChI=1S/C23H17N5O/c1-28-15-19(22-20(28)3-2-10-25-22)16-4-6-18(7-5-16)29-23-21(26-13-14-27-23)17-8-11-24-12-9-17/h2-15H,1H3
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n/an/a 12n/an/an/an/an/an/a



Glenmark Pharmaceuticals Ltd

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant GST-tagged PDE10A using [3H]-cAMP as substrate after 30 mins by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Mus musculus)
BDBM50390152
PNG
(CHEMBL2069677)
Show SMILES COC(C(=O)N\N=C\c1cc(OC)c(Br)c(OC)c1)c1ccc(cc1)N1CCN(C)CC1
Show InChI InChI=1S/C23H29BrN4O4/c1-27-9-11-28(12-10-27)18-7-5-17(6-8-18)22(32-4)23(29)26-25-15-16-13-19(30-2)21(24)20(14-16)31-3/h5-8,13-15,22H,9-12H2,1-4H3,(H,26,29)/b25-15+
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n/an/a 12n/an/an/an/an/an/a



Omeros Corp.

Curated by ChEMBL


Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Mus musculus)
BDBM50390114
PNG
(CHEMBL2069672)
Show SMILES COC(C(=O)N\N=C\c1cc(OC)c(C)c(OC)c1)c1ccc2OCCOc2c1
Show InChI InChI=1S/C21H24N2O6/c1-13-17(25-2)9-14(10-18(13)26-3)12-22-23-21(24)20(27-4)15-5-6-16-19(11-15)29-8-7-28-16/h5-6,9-12,20H,7-8H2,1-4H3,(H,23,24)/b22-12+
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n/an/a 14n/an/an/an/an/an/a



Omeros Corp.

Curated by ChEMBL


Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Mus musculus)
BDBM50348345
PNG
(CHEMBL1800312)
Show SMILES COc1cc(\C=N\NC(=O)CSc2cc(C)nc3ccccc23)cc(OC)c1C#N
Show InChI InChI=1S/C22H20N4O3S/c1-14-8-21(16-6-4-5-7-18(16)25-14)30-13-22(27)26-24-12-15-9-19(28-2)17(11-23)20(10-15)29-3/h4-10,12H,13H2,1-3H3,(H,26,27)/b24-12+
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n/an/a 14n/an/an/an/an/an/a



Omeros Corp.

Curated by ChEMBL


Assay Description
Inhibition of mouse PDE10A assessed as inhibition of hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Mus musculus)
BDBM50390146
PNG
(CHEMBL2069683)
Show SMILES COC(C(=O)N\N=C\c1cc(OC)c(Br)c(OC)c1)c1cccnc1
Show InChI InChI=1S/C17H18BrN3O4/c1-23-13-7-11(8-14(24-2)15(13)18)9-20-21-17(22)16(25-3)12-5-4-6-19-10-12/h4-10,16H,1-3H3,(H,21,22)/b20-9+
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n/an/a 17n/an/an/an/an/an/a



Omeros Corp.

Curated by ChEMBL


Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Mus musculus)
BDBM50390123
PNG
(CHEMBL2069662)
Show SMILES COC(C(=O)N\N=C\c1cc(Br)c(OC)c(OC)c1)c1ccc2OCCOc2c1
Show InChI InChI=1S/C20H21BrN2O6/c1-25-17-9-12(8-14(21)19(17)27-3)11-22-23-20(24)18(26-2)13-4-5-15-16(10-13)29-7-6-28-15/h4-5,8-11,18H,6-7H2,1-3H3,(H,23,24)/b22-11+
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n/an/a 19n/an/an/an/an/an/a



Omeros Corp.

Curated by ChEMBL


Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Mus musculus)
BDBM50048263
PNG
(CHEMBL3315039)
Show SMILES Cn1cc(-c2ccc(Oc3nccnc3-c3ccncc3)cc2)c2nc3ccccc3cc12
Show InChI InChI=1S/C27H19N5O/c1-32-17-22(26-24(32)16-20-4-2-3-5-23(20)31-26)18-6-8-21(9-7-18)33-27-25(29-14-15-30-27)19-10-12-28-13-11-19/h2-17H,1H3
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n/an/a 23n/an/an/an/an/an/a



Glenmark Pharmaceuticals Ltd

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant GST-tagged PDE10A using [3H]-cAMP as substrate after 30 mins by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Mus musculus)
BDBM50348335
PNG
(CHEMBL1800234)
Show SMILES COc1cc(\C=N\NC(=O)CSc2ccnc3ccccc23)cc(OC)c1OC
Show InChI InChI=1S/C21H21N3O4S/c1-26-17-10-14(11-18(27-2)21(17)28-3)12-23-24-20(25)13-29-19-8-9-22-16-7-5-4-6-15(16)19/h4-12H,13H2,1-3H3,(H,24,25)/b23-12+
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n/an/a 24n/an/an/an/an/an/a



Omeros Corp.

Curated by ChEMBL


Assay Description
Inhibition of mouse PDE10A assessed as inhibition of hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Mus musculus)
BDBM50348328
PNG
(CHEMBL1800240)
Show SMILES COc1cc(\C=N\N(C)C(=O)CSc2cc(C)nc3ccccc23)cc(OC)c1OC
Show InChI InChI=1S/C23H25N3O4S/c1-15-10-21(17-8-6-7-9-18(17)25-15)31-14-22(27)26(2)24-13-16-11-19(28-3)23(30-5)20(12-16)29-4/h6-13H,14H2,1-5H3/b24-13+
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n/an/a 26n/an/an/an/an/an/a



Omeros Corp.

Curated by ChEMBL


Assay Description
Inhibition of mouse PDE10A assessed as inhibition of hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Mus musculus)
BDBM50348334
PNG
(CHEMBL1800235)
Show SMILES COc1cc(\C=N\NC(=O)CSc2ccnc3cc(Cl)ccc23)cc(OC)c1OC
Show InChI InChI=1S/C21H20ClN3O4S/c1-27-17-8-13(9-18(28-2)21(17)29-3)11-24-25-20(26)12-30-19-6-7-23-16-10-14(22)4-5-15(16)19/h4-11H,12H2,1-3H3,(H,25,26)/b24-11+
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n/an/a 28n/an/an/an/an/an/a



Omeros Corp.

Curated by ChEMBL


Assay Description
Inhibition of mouse PDE10A assessed as inhibition of hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Mus musculus)
BDBM50390132
PNG
(CHEMBL2069654)
Show SMILES COC(C(=O)N\N=C\c1cc(OC)c(OC)c(OC)c1)c1ccc2OCCOc2c1
Show InChI InChI=1S/C21H24N2O7/c1-25-17-9-13(10-18(26-2)20(17)28-4)12-22-23-21(24)19(27-3)14-5-6-15-16(11-14)30-8-7-29-15/h5-6,9-12,19H,7-8H2,1-4H3,(H,23,24)/b22-12+
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n/an/a 28n/an/an/an/an/an/a



Omeros Corp.

Curated by ChEMBL


Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Mus musculus)
BDBM50348348
PNG
(CHEMBL1800309)
Show SMILES COc1cc(\C=N\NC(=O)CSc2cc(C)nc3ccccc23)cc(Br)c1OC
Show InChI InChI=1S/C21H20BrN3O3S/c1-13-8-19(15-6-4-5-7-17(15)24-13)29-12-20(26)25-23-11-14-9-16(22)21(28-3)18(10-14)27-2/h4-11H,12H2,1-3H3,(H,25,26)/b23-11+
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n/an/a 30n/an/an/an/an/an/a



Omeros Corp.

Curated by ChEMBL


Assay Description
Inhibition of mouse PDE10A assessed as inhibition of hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Mus musculus)
BDBM50390124
PNG
(CHEMBL2069661)
Show SMILES COC(C(=O)N\N=C\c1cc(Cl)c(OC)c(OC)c1)c1ccc2OCCOc2c1
Show InChI InChI=1S/C20H21ClN2O6/c1-25-17-9-12(8-14(21)19(17)27-3)11-22-23-20(24)18(26-2)13-4-5-15-16(10-13)29-7-6-28-15/h4-5,8-11,18H,6-7H2,1-3H3,(H,23,24)/b22-11+
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n/an/a 32n/an/an/an/an/an/a



Omeros Corp.

Curated by ChEMBL


Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Mus musculus)
BDBM50390130
PNG
(CHEMBL2069656)
Show SMILES CCOc1cc(\C=N\NC(=O)C(OC)c2ccc3OCCOc3c2)ccc1OC
Show InChI InChI=1S/C21H24N2O6/c1-4-27-18-11-14(5-7-16(18)25-2)13-22-23-21(24)20(26-3)15-6-8-17-19(12-15)29-10-9-28-17/h5-8,11-13,20H,4,9-10H2,1-3H3,(H,23,24)/b22-13+
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n/an/a 43n/an/an/an/an/an/a



Omeros Corp.

Curated by ChEMBL


Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Mus musculus)
BDBM50348347
PNG
(CHEMBL1800310)
Show SMILES COc1cc(\C=N\NC(=O)CSc2cc(C)nc3ccccc23)cc(Cl)c1OC
Show InChI InChI=1S/C21H20ClN3O3S/c1-13-8-19(15-6-4-5-7-17(15)24-13)29-12-20(26)25-23-11-14-9-16(22)21(28-3)18(10-14)27-2/h4-11H,12H2,1-3H3,(H,25,26)/b23-11+
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n/an/a 45n/an/an/an/an/an/a



Omeros Corp.

Curated by ChEMBL


Assay Description
Inhibition of mouse PDE10A assessed as inhibition of hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
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