Compile Data Set for Download or QSAR

Found 141 hits Enz. Inhib. hit(s) with Target = 'cAMP-specific 3',5'-cyclic phosphodiesterase 4A'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP-specific 3',5'-cyclic phosphodiesterase 4A (Cavia porcellus)	BDBM15296 (6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...) Show SMILES Cc1[nH]c(=O)c(cc1-c1ccncc1)C#N Show InChI InChI=1S/C12H9N3O/c1-8-11(9-2-4-14-5-3-9)6-10(7-13)12(16)15-8/h2-6H,1H3,(H,15,16)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars		4.67E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of Cavia porcellus (guinea pig) PDE3 isolated from heart using [3H]cAMP as substrate by two-step method				Citation and Details BindingDB Entry DOI: 10.7270/Q2PV6P8K
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 4 (Homo sapiens (Human))	BDBM285634 (3-(4-chloro-3,5-difluoro-phenyl)-N-cyclopropyl-imi...) Show SMILES Fc1cc(cc(F)c1Cl)-c1c(nc2cccnn12)C(=O)NC1CC1 Show InChI InChI=1S/C16H11ClF2N4O/c17-13-10(18)6-8(7-11(13)19)15-14(16(24)21-9-3-4-9)22-12-2-1-5-20-23(12)15/h1-2,5-7,9H,3-4H2,(H,21,24)	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.488	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 4 (Homo sapiens (Human))	BDBM285598 (3-(3-chloro-4-methylphenyl)-N-[(1R,2S)-2-fluorocyc...) Show SMILES Cc1ccc(cc1Cl)-c1c(nc2cccnn12)C(=O)N[C@@H]1C[C@@H]1F Show InChI InChI=1S/C17H14ClFN4O/c1-9-4-5-10(7-11(9)18)16-15(17(24)21-13-8-12(13)19)22-14-3-2-6-20-23(14)16/h2-7,12-13H,8H2,1H3,(H,21,24)/t12-,13+/m0/s1	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.669	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3 (Homo sapiens (Human))	BDBM399979 (US10323042, Example 58) Show SMILES Fc1cc(-c2c3OCC(F)(F)Cn3nc2C(=O)NC2CC2)c(F)cc1Cl Show InChI InChI=1S/C16H12ClF4N3O2/c17-9-4-10(18)8(3-11(9)19)12-13(14(25)22-7-1-2-7)23-24-5-16(20,21)6-26-15(12)24/h3-4,7H,1-2,5-6H2,(H,22,25)	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10323042 (2019) BindingDB Entry DOI: 10.7270/Q2NP26RH
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 4 (Homo sapiens (Human))	BDBM285537 (3-(4-chloro-3-fluoro-phenyl)-N-cyclopropyl-imidazo...) Show SMILES Fc1cc(ccc1Cl)-c1c(nc2cccnn12)C(=O)NC1CC1 Show InChI InChI=1S/C16H12ClFN4O/c17-11-6-3-9(8-12(11)18)15-14(16(23)20-10-4-5-10)21-13-2-1-7-19-22(13)15/h1-3,6-8,10H,4-5H2,(H,20,23)	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	1.51	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3 (Homo sapiens (Human))	BDBM399978 (US10323042, Example 57) Show SMILES Cc1cc(Cl)c(F)cc1-c1c(nn2C[C@H](F)COc12)C(=O)NC1CC1 Show InChI InChI=1S/C17H16ClF2N3O2/c1-8-4-12(18)13(20)5-11(8)14-15(16(24)21-10-2-3-10)22-23-6-9(19)7-25-17(14)23/h4-5,9-10H,2-3,6-7H2,1H3,(H,21,24)/t9-/m0/s1	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	1.86	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10323042 (2019) BindingDB Entry DOI: 10.7270/Q2NP26RH
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3 (Homo sapiens (Human))	BDBM399927 ((6S)-3-(4-Chloro-2,5-difluorophenyl)-N-cyclopropyl...) Show SMILES F[C@@H]1COc2c(c(nn2C1)C(=O)NC1CC1)-c1cc(F)c(Cl)cc1F Show InChI InChI=1S/C16H13ClF3N3O2/c17-10-4-11(19)9(3-12(10)20)13-14(15(24)21-8-1-2-8)22-23-5-7(18)6-25-16(13)23/h3-4,7-8H,1-2,5-6H2,(H,21,24)/t7-/m0/s1	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10323042 (2019) BindingDB Entry DOI: 10.7270/Q2NP26RH
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 4 (Homo sapiens (Human))	BDBM285534 (3-(4-Chloro-3-fluorophenyl)-N-(1-methyl-1H-pyrazol...) Show SMILES Cn1cc(NC(=O)c2nc3cccnn3c2-c2ccc(Cl)c(F)c2)cn1 Show InChI InChI=1S/C17H12ClFN6O/c1-24-9-11(8-21-24)22-17(26)15-16(10-4-5-12(18)13(19)7-10)25-14(23-15)3-2-6-20-25/h2-9H,1H3,(H,22,26)	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	2.77	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 4 (Homo sapiens (Human))	BDBM285572 (3-(4-chloro-3-fluorophenyl)-N-[(1R,2S)-2-fluorocyc...) Show SMILES F[C@H]1C[C@H]1NC(=O)c1nc2cccnn2c1-c1ccc(Cl)c(F)c1 Show InChI InChI=1S/C16H11ClF2N4O/c17-9-4-3-8(6-10(9)18)15-14(16(24)21-12-7-11(12)19)22-13-2-1-5-20-23(13)15/h1-6,11-12H,7H2,(H,21,24)/t11-,12+/m0/s1	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	2.91	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 4 (Homo sapiens (Human))	BDBM285568 (N-cyclopropyl-3-(3-fluoro-4-methylphenyl)imidazo[1...) Show SMILES Cc1ccc(cc1F)-c1c(nc2cccnn12)C(=O)NC1CC1 Show InChI InChI=1S/C17H15FN4O/c1-10-4-5-11(9-13(10)18)16-15(17(23)20-12-6-7-12)21-14-3-2-8-19-22(14)16/h2-5,8-9,12H,6-7H2,1H3,(H,20,23)	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	3.13	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 4 (Homo sapiens (Human))	BDBM285556 (3-(4-chloro-3-fluorophenyl)-N-propylimidazo[1,2-b]...) Show SMILES CCCNC(=O)c1nc2cccnn2c1-c1ccc(Cl)c(F)c1 Show InChI InChI=1S/C16H14ClFN4O/c1-2-7-19-16(23)14-15(10-5-6-11(17)12(18)9-10)22-13(21-14)4-3-8-20-22/h3-6,8-9H,2,7H2,1H3,(H,19,23)	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	3.48	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 4 (Homo sapiens (Human))	BDBM285536 (3-(4-Chloro-2,5-difluorophenyl)-N-cyclopropylimida...) Show SMILES Fc1cc(-c2c(nc3cccnn23)C(=O)NC2CC2)c(F)cc1Cl Show InChI InChI=1S/C16H11ClF2N4O/c17-10-7-11(18)9(6-12(10)19)15-14(16(24)21-8-3-4-8)22-13-2-1-5-20-23(13)15/h1-2,5-8H,3-4H2,(H,21,24)	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	3.83	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 4 (Homo sapiens (Human))	BDBM285576 (US10077269, Example 49 | US9598421, Example 49 | a...) Show SMILES Cc1ccc(cc1Cl)-c1c(nc2cccnn12)C(=O)N1CCC1 Show InChI InChI=1S/C17H15ClN4O/c1-11-5-6-12(10-13(11)18)16-15(17(23)21-8-3-9-21)20-14-4-2-7-19-22(14)16/h2,4-7,10H,3,8-9H2,1H3	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	4.16	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 4 (Homo sapiens (Human))	BDBM285626 (3-(4-chloro-2,5-difluoro-phenyl)-N-ethylimidazo[1,...) Show SMILES CCNC(=O)c1nc2cccnn2c1-c1cc(F)c(Cl)cc1F Show InChI InChI=1S/C15H11ClF2N4O/c1-2-19-15(23)13-14(22-12(21-13)4-3-5-20-22)8-6-11(18)9(16)7-10(8)17/h3-7H,2H2,1H3,(H,19,23)	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	4.58	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 4 (Homo sapiens (Human))	BDBM285551 (4-[2-(azetidin-1-ylcarbonyl)imidazo[1,2-b]pyridazi...) Show SMILES Fc1cc(-c2c(nc3cccnn23)C(=O)N2CCC2)c(F)cc1C#N Show InChI InChI=1S/C17H11F2N5O/c18-12-8-11(13(19)7-10(12)9-20)16-15(17(25)23-5-2-6-23)22-14-3-1-4-21-24(14)16/h1,3-4,7-8H,2,5-6H2	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	5.04	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 4 (Homo sapiens (Human))	BDBM285540 (US10077269, Example 13 | US9598421, Example 13 | a...) Show SMILES Fc1cc(ccc1Cl)-c1c(nc2cccnn12)C(=O)N1CCC1 Show InChI InChI=1S/C16H12ClFN4O/c17-11-5-4-10(9-12(11)18)15-14(16(23)21-7-2-8-21)20-13-3-1-6-19-22(13)15/h1,3-6,9H,2,7-8H2	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	5.13	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3 (Homo sapiens (Human))	BDBM399928 (3-(4-Chloro-2-methylphenyl)-N-cyclopropyl-6,6-difl...) Show SMILES Cc1cc(Cl)ccc1-c1c2OCC(F)(F)Cn2nc1C(=O)NC1CC1 Show InChI InChI=1S/C17H16ClF2N3O2/c1-9-6-10(18)2-5-12(9)13-14(15(24)21-11-3-4-11)22-23-7-17(19,20)8-25-16(13)23/h2,5-6,11H,3-4,7-8H2,1H3,(H,21,24)	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	5.29	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10323042 (2019) BindingDB Entry DOI: 10.7270/Q2NP26RH
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3 (Homo sapiens (Human))	BDBM399973 (US10323042, Example 53A | US10323042, Example 53B) Show SMILES Cc1cc(C#N)c(F)cc1-c1c(nn2C[C@H](F)COc12)C(=O)NC1CC1 Show InChI InChI=1S/C18H16F2N4O2/c1-9-4-10(6-21)14(20)5-13(9)15-16(17(25)22-12-2-3-12)23-24-7-11(19)8-26-18(15)24/h4-5,11-12H,2-3,7-8H2,1H3,(H,22,25)/t11-/m0/s1	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	5.35	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10323042 (2019) BindingDB Entry DOI: 10.7270/Q2NP26RH
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 4 (Homo sapiens (Human))	BDBM285627 (3-(4-chloro-5-fluoro-2-methylphenyl)-N-(propan-2-y...) Show SMILES CC(C)NC(=O)c1nc2cccnn2c1-c1cc(F)c(Cl)cc1C Show InChI InChI=1S/C17H16ClFN4O/c1-9(2)21-17(24)15-16(23-14(22-15)5-4-6-20-23)11-8-13(19)12(18)7-10(11)3/h4-9H,1-3H3,(H,21,24)	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	5.48	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 4 (Homo sapiens (Human))	BDBM285622 (3-(4-cyano-2,5-difluorophenyl)-N-cyclopropylimidaz...) Show SMILES Fc1cc(-c2c(nc3cccnn23)C(=O)NC2CC2)c(F)cc1C#N Show InChI InChI=1S/C17H11F2N5O/c18-12-7-11(13(19)6-9(12)8-20)16-15(17(25)22-10-3-4-10)23-14-2-1-5-21-24(14)16/h1-2,5-7,10H,3-4H2,(H,22,25)	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	5.52	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 4 (Homo sapiens (Human))	BDBM285616 (US10077269, Example 86 | US9598421, Example 86 | a...) Show SMILES FC1(F)Oc2ccc(cc2O1)-c1c(nc2cccnn12)C(=O)N1CCC1 Show InChI InChI=1S/C17H12F2N4O3/c18-17(19)25-11-5-4-10(9-12(11)26-17)15-14(16(24)22-7-2-8-22)21-13-3-1-6-20-23(13)15/h1,3-6,9H,2,7-8H2	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	5.83	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 4 (Homo sapiens (Human))	BDBM285613 (US10077269, Example 83 | US9598421, Example 83 | a...) Show SMILES Clc1ccc(cc1Cl)-c1c(nc2cccnn12)C(=O)N1CCC1 Show InChI InChI=1S/C16H12Cl2N4O/c17-11-5-4-10(9-12(11)18)15-14(16(23)21-7-2-8-21)20-13-3-1-6-19-22(13)15/h1,3-6,9H,2,7-8H2	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	6.21	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3 (Homo sapiens (Human))	BDBM399973 (US10323042, Example 53A | US10323042, Example 53B) Show SMILES Cc1cc(C#N)c(F)cc1-c1c(nn2C[C@H](F)COc12)C(=O)NC1CC1 Show InChI InChI=1S/C18H16F2N4O2/c1-9-4-10(6-21)14(20)5-13(9)15-16(17(25)22-12-2-3-12)23-24-7-11(19)8-26-18(15)24/h4-5,11-12H,2-3,7-8H2,1H3,(H,22,25)/t11-/m0/s1	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	6.45	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10323042 (2019) BindingDB Entry DOI: 10.7270/Q2NP26RH
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 4 (Homo sapiens (Human))	BDBM285547 (4-[2-(azetidin-1-ylcarbonyl)imidazo[1,2-b]pyridazi...) Show SMILES Cc1cc(C#N)c(F)cc1-c1c(nc2cccnn12)C(=O)N1CCC1 Show InChI InChI=1S/C18H14FN5O/c1-11-8-12(10-20)14(19)9-13(11)17-16(18(25)23-6-3-7-23)22-15-4-2-5-21-24(15)17/h2,4-5,8-9H,3,6-7H2,1H3	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	6.70	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 4 (Homo sapiens (Human))	BDBM285603 (US10077269, Example 76 | US9598421, Example 76 | a...) Show SMILES FC(F)Oc1cc(ccn1)-c1c(nc2cccnn12)C(=O)N1CCC1 Show InChI InChI=1S/C16H13F2N5O2/c17-16(18)25-12-9-10(4-6-19-12)14-13(15(24)22-7-2-8-22)21-11-3-1-5-20-23(11)14/h1,3-6,9,16H,2,7-8H2	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	7.09	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 4 (Homo sapiens (Human))	BDBM285574 (US10077269, Example 47 | US9598421, Example 47 | a...) Show SMILES Fc1cc(cc(F)c1Cl)-c1c(nc2cccnn12)C(=O)N1CCC1 Show InChI InChI=1S/C16H11ClF2N4O/c17-13-10(18)7-9(8-11(13)19)15-14(16(24)22-5-2-6-22)21-12-3-1-4-20-23(12)15/h1,3-4,7-8H,2,5-6H2	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	7.37	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 4 (Homo sapiens (Human))	BDBM285611 (3-(4-chloro-3-fluorophenyl)-N-ethylimidazo[1,2-b]p...) Show SMILES CCNC(=O)c1nc2cccnn2c1-c1ccc(Cl)c(F)c1 Show InChI InChI=1S/C15H12ClFN4O/c1-2-18-15(22)13-14(9-5-6-10(16)11(17)8-9)21-12(20-13)4-3-7-19-21/h3-8H,2H2,1H3,(H,18,22)	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	7.86	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 4 (Homo sapiens (Human))	BDBM285602 (N-cyclopropyl-3-[2-(difluoro-methoxy)pyridin-4-yl]...) Show SMILES FC(F)Oc1cc(ccn1)-c1c(nc2cccnn12)C(=O)NC1CC1 Show InChI InChI=1S/C16H13F2N5O2/c17-16(18)25-12-8-9(5-7-19-12)14-13(15(24)21-10-3-4-10)22-11-2-1-6-20-23(11)14/h1-2,5-8,10,16H,3-4H2,(H,21,24)	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	10.5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 4 (Homo sapiens (Human))	BDBM285595 (3-(4-chloro-2-fluorophenyl)-N-[(1R,2S)-2-fluorocyc...) Show SMILES F[C@H]1C[C@H]1NC(=O)c1nc2cccnn2c1-c1ccc(Cl)cc1F Show InChI InChI=1S/C16H11ClF2N4O/c17-8-3-4-9(10(18)6-8)15-14(16(24)21-12-7-11(12)19)22-13-2-1-5-20-23(13)15/h1-6,11-12H,7H2,(H,21,24)/t11-,12+/m0/s1	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	10.6	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 4 (Homo sapiens (Human))	BDBM285529 (3-(4-Chlorophenyl)-N-cyclopropylimidazo[1,2-b]pyri...) Show SMILES Clc1ccc(cc1)-c1c(nc2cccnn12)C(=O)NC1CC1 Show InChI InChI=1S/C16H13ClN4O/c17-11-5-3-10(4-6-11)15-14(16(22)19-12-7-8-12)20-13-2-1-9-18-21(13)15/h1-6,9,12H,7-8H2,(H,19,22)	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	10.7	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3 (Homo sapiens (Human))	BDBM399937 (US10323042, Example 17) Show SMILES Cc1cc(Cl)c(F)cc1-c1c2OCCCn2nc1C(=O)NC1CC1 Show InChI InChI=1S/C17H17ClFN3O2/c1-9-7-12(18)13(19)8-11(9)14-15(16(23)20-10-3-4-10)21-22-5-2-6-24-17(14)22/h7-8,10H,2-6H2,1H3,(H,20,23)	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10323042 (2019) BindingDB Entry DOI: 10.7270/Q2NP26RH
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 4 (Homo sapiens (Human))	BDBM285557 (3-(4-chlorophenyl)-N-(2-methylcyclopropyl)imidazo[...) Show SMILES CC1CC1NC(=O)c1nc2cccnn2c1-c1ccc(Cl)cc1 Show InChI InChI=1S/C17H15ClN4O/c1-10-9-13(10)20-17(23)15-16(11-4-6-12(18)7-5-11)22-14(21-15)3-2-8-19-22/h2-8,10,13H,9H2,1H3,(H,20,23)	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	11.6	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 4 (Homo sapiens (Human))	BDBM285612 (3-(4-chloro-3-fluorophenyl)-N-(1H-pyrazol-4-yl)imi...) Show SMILES Fc1cc(ccc1Cl)-c1c(nc2cccnn12)C(=O)Nc1cn[nH]c1 Show InChI InChI=1S/C16H10ClFN6O/c17-11-4-3-9(6-12(11)18)15-14(16(25)22-10-7-19-20-8-10)23-13-2-1-5-21-24(13)15/h1-8H,(H,19,20)(H,22,25)	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3 (Homo sapiens (Human))	BDBM399971 (US10323042, Example 51) Show SMILES Cc1cc(C#N)c(F)cc1-c1c(nn2CC(F)COc12)C(=O)NC1CC1 Show InChI InChI=1S/C18H16F2N4O2/c1-9-4-10(6-21)14(20)5-13(9)15-16(17(25)22-12-2-3-12)23-24-7-11(19)8-26-18(15)24/h4-5,11-12H,2-3,7-8H2,1H3,(H,22,25)	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10323042 (2019) BindingDB Entry DOI: 10.7270/Q2NP26RH
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3 (Homo sapiens (Human))	BDBM399968 (US10323042, Example 48) Show SMILES Cc1cc(Cl)c(F)cc1-c1c2OCCCn2nc1C(=O)N1CCC1 Show InChI InChI=1S/C17H17ClFN3O2/c1-10-8-12(18)13(19)9-11(10)14-15(16(23)21-4-2-5-21)20-22-6-3-7-24-17(14)22/h8-9H,2-7H2,1H3	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	12.1	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10323042 (2019) BindingDB Entry DOI: 10.7270/Q2NP26RH
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 4 (Homo sapiens (Human))	BDBM285621 (US10077269, Example 91 | US9598421, Example 91 | a...) Show SMILES Fc1cc(-c2c(nc3cccnn23)C(=O)N2CCC2)c(F)cc1Cl Show InChI InChI=1S/C16H11ClF2N4O/c17-10-8-11(18)9(7-12(10)19)15-14(16(24)22-5-2-6-22)21-13-3-1-4-20-23(13)15/h1,3-4,7-8H,2,5-6H2	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	12.6	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 4 (Homo sapiens (Human))	BDBM285530 (Azetidin-1-yl[3-(3,5-difluoro-4-methoxyphenyl)imid...) Show SMILES COc1c(F)cc(cc1F)-c1c(nc2cccnn12)C(=O)N1CCC1 Show InChI InChI=1S/C17H14F2N4O2/c1-25-16-11(18)8-10(9-12(16)19)15-14(17(24)22-6-3-7-22)21-13-4-2-5-20-23(13)15/h2,4-5,8-9H,3,6-7H2,1H3	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	12.7	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3 (Homo sapiens (Human))	BDBM399969 (US10323042, Example 49) Show SMILES Fc1cc(cc(F)c1Cl)-c1c2OCCCn2nc1C(=O)N1CCC1 Show InChI InChI=1S/C16H14ClF2N3O2/c17-13-10(18)7-9(8-11(13)19)12-14(15(23)21-3-1-4-21)20-22-5-2-6-24-16(12)22/h7-8H,1-6H2	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	13.3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10323042 (2019) BindingDB Entry DOI: 10.7270/Q2NP26RH
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 4 (Homo sapiens (Human))	BDBM285539 (3-(4-chloro-2-methyl-phenyl)-N-cyclopropyl-imidazo...) Show SMILES Cc1cc(Cl)ccc1-c1c(nc2cccnn12)C(=O)NC1CC1 Show InChI InChI=1S/C17H15ClN4O/c1-10-9-11(18)4-7-13(10)16-15(17(23)20-12-5-6-12)21-14-3-2-8-19-22(14)16/h2-4,7-9,12H,5-6H2,1H3,(H,20,23)	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	14.4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3 (Homo sapiens (Human))	BDBM399926 ((6S)-3-(4-Chloro-2-methylphenyl)-N-cyclopropyl-6-f...) Show SMILES Cc1cc(Cl)ccc1-c1c(nn2C[C@H](F)COc12)C(=O)NC1CC1 Show InChI InChI=1S/C17H17ClFN3O2/c1-9-6-10(18)2-5-13(9)14-15(16(23)20-12-3-4-12)21-22-7-11(19)8-24-17(14)22/h2,5-6,11-12H,3-4,7-8H2,1H3,(H,20,23)/t11-/m0/s1	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	14.4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10323042 (2019) BindingDB Entry DOI: 10.7270/Q2NP26RH
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 4 (Homo sapiens (Human))	BDBM285566 (3-(1,3-benzoxazol-5-yl)-N-cyclopropylimidazo[1,2-b...) Show SMILES O=C(NC1CC1)c1nc2cccnn2c1-c1ccc2ocnc2c1 Show InChI InChI=1S/C17H13N5O2/c23-17(20-11-4-5-11)15-16(22-14(21-15)2-1-7-19-22)10-3-6-13-12(8-10)18-9-24-13/h1-3,6-9,11H,4-5H2,(H,20,23)	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	14.8	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 4 (Homo sapiens (Human))	BDBM285550 (4-[2-(azetidin-1-ylcarbonyl)imidazo[1,2-b]pyridazi...) Show SMILES Fc1cc(ccc1C#N)-c1c(nc2cccnn12)C(=O)N1CCC1 Show InChI InChI=1S/C17H12FN5O/c18-13-9-11(4-5-12(13)10-19)16-15(17(24)22-7-2-8-22)21-14-3-1-6-20-23(14)16/h1,3-6,9H,2,7-8H2	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	15.1	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 4 (Homo sapiens (Human))	BDBM285573 (3-(4-chlorophenyl)-N-[(1R,2S)-2-fluorocyclopro-pyl...) Show SMILES F[C@H]1C[C@H]1NC(=O)c1nc2cccnn2c1-c1ccc(Cl)cc1 Show InChI InChI=1S/C16H12ClFN4O/c17-10-5-3-9(4-6-10)15-14(16(23)20-12-8-11(12)18)21-13-2-1-7-19-22(13)15/h1-7,11-12H,8H2,(H,20,23)/t11-,12+/m0/s1	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	15.2	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 4 (Homo sapiens (Human))	BDBM285555 (3-(3,5-dichlorophenyl)-N-propylimidazo[1,2-b]pyrid...) Show SMILES CCCNC(=O)c1nc2cccnn2c1-c1cc(Cl)cc(Cl)c1 Show InChI InChI=1S/C16H14Cl2N4O/c1-2-5-19-16(23)14-15(10-7-11(17)9-12(18)8-10)22-13(21-14)4-3-6-20-22/h3-4,6-9H,2,5H2,1H3,(H,19,23)	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	15.6	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3 (Homo sapiens (Human))	BDBM399967 (US10323042, Example 47) Show SMILES Fc1cc(cc(F)c1Cl)-c1c2OCCCn2nc1C(=O)NC1CC1 Show InChI InChI=1S/C16H14ClF2N3O2/c17-13-10(18)6-8(7-11(13)19)12-14(15(23)20-9-2-3-9)21-22-4-1-5-24-16(12)22/h6-7,9H,1-5H2,(H,20,23)	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	15.7	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10323042 (2019) BindingDB Entry DOI: 10.7270/Q2NP26RH
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 4 (Homo sapiens (Human))	BDBM285614 (US10077269, Example 84 | US9598421, Example 84 | a...) Show SMILES Clc1cccc(c1)-c1c(nc2cccnn12)C(=O)N1CCC1 Show InChI InChI=1S/C16H13ClN4O/c17-12-5-1-4-11(10-12)15-14(16(22)20-8-3-9-20)19-13-6-2-7-18-21(13)15/h1-2,4-7,10H,3,8-9H2	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	16.7	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 4 (Homo sapiens (Human))	BDBM285546 (3-(4-cyano-5-fluoro-2-methylphenyl)-N-cyclo-propyl...) Show SMILES Cc1cc(C#N)c(F)cc1-c1c(nc2cccnn12)C(=O)NC1CC1 Show InChI InChI=1S/C18H14FN5O/c1-10-7-11(9-20)14(19)8-13(10)17-16(18(25)22-12-4-5-12)23-15-3-2-6-21-24(15)17/h2-3,6-8,12H,4-5H2,1H3,(H,22,25)	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	16.9	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 4 (Homo sapiens (Human))	BDBM285580 (US10077269, Example 53 | US9598421, Example 53 | a...) Show SMILES Cc1cc(cc(C)c1F)-c1c(nc2cccnn12)C(=O)N1CCC1 Show InChI InChI=1S/C18H17FN4O/c1-11-9-13(10-12(2)15(11)19)17-16(18(24)22-7-4-8-22)21-14-5-3-6-20-23(14)17/h3,5-6,9-10H,4,7-8H2,1-2H3	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	17.8	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 4 (Homo sapiens (Human))	BDBM285567 (3-(4-chloro-2-fluorophenyl)-N-cyclopropylimidazo[1...) Show SMILES Fc1cc(Cl)ccc1-c1c(nc2cccnn12)C(=O)NC1CC1 Show InChI InChI=1S/C16H12ClFN4O/c17-9-3-6-11(12(18)8-9)15-14(16(23)20-10-4-5-10)21-13-2-1-7-19-22(13)15/h1-3,6-8,10H,4-5H2,(H,20,23)	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	19.6	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3 (Homo sapiens (Human))	BDBM399960 (US10323042, Example 40) Show SMILES FC1COc2c(c(nn2C1)C(=O)NC1CC1)-c1ccc(Cl)c(F)c1 Show InChI InChI=1S/C16H14ClF2N3O2/c17-11-4-1-8(5-12(11)19)13-14(15(23)20-10-2-3-10)21-22-6-9(18)7-24-16(13)22/h1,4-5,9-10H,2-3,6-7H2,(H,20,23)	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	19.7	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10323042 (2019) BindingDB Entry DOI: 10.7270/Q2NP26RH
					More data for this Ligand-Target Pair

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