Found 172 hits Enz. Inhib. hit(s) with Target = 'cAMP-specific 3',5'-cyclic phosphodiesterase 4B' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(RAT) | BDBM14775
 (3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)Show InChI InChI=1S/C18H18Cl2N2O3/c1-24-15-7-6-11(8-16(15)25-12-4-2-3-5-12)18(23)22-17-13(19)9-21-10-14(17)20/h6-10,12H,2-5H2,1H3,(H,21,22,23) | PDB
Reactome pathway
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| 0.0400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tennessee
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 305: 565-72 (2003)
Article DOI: 10.1124/jpet.102.47407 BindingDB Entry DOI: 10.7270/Q23B5XQG |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(RAT) | BDBM14774
 (3-(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl...)Show SMILES FC(F)Oc1ccc(cc1OCC1CC1)C(=O)Nc1c(Cl)cncc1Cl Show InChI InChI=1S/C17H14Cl2F2N2O3/c18-11-6-22-7-12(19)15(11)23-16(24)10-3-4-13(26-17(20)21)14(5-10)25-8-9-1-2-9/h3-7,9,17H,1-2,8H2,(H,22,23,24) | PDB
Reactome pathway
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| 2.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tennessee
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 305: 565-72 (2003)
Article DOI: 10.1124/jpet.102.47407 BindingDB Entry DOI: 10.7270/Q23B5XQG |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(RAT) | BDBM14774
 (3-(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl...)Show SMILES FC(F)Oc1ccc(cc1OCC1CC1)C(=O)Nc1c(Cl)cncc1Cl Show InChI InChI=1S/C17H14Cl2F2N2O3/c18-11-6-22-7-12(19)15(11)23-16(24)10-3-4-13(26-17(20)21)14(5-10)25-8-9-1-2-9/h3-7,9,17H,1-2,8H2,(H,22,23,24) | PDB
Reactome pathway
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| 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tennessee
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 305: 565-72 (2003)
Article DOI: 10.1124/jpet.102.47407 BindingDB Entry DOI: 10.7270/Q23B5XQG |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(RAT) | BDBM14775
 (3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)Show InChI InChI=1S/C18H18Cl2N2O3/c1-24-15-7-6-11(8-16(15)25-12-4-2-3-5-12)18(23)22-17-13(19)9-21-10-14(17)20/h6-10,12H,2-5H2,1H3,(H,21,22,23) | PDB
Reactome pathway
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| 9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tennessee
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 305: 565-72 (2003)
Article DOI: 10.1124/jpet.102.47407 BindingDB Entry DOI: 10.7270/Q23B5XQG |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(RAT) | BDBM14361
 ((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18) | PDB
Reactome pathway
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| 16.6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tennessee
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 305: 565-72 (2003)
Article DOI: 10.1124/jpet.102.47407 BindingDB Entry DOI: 10.7270/Q23B5XQG |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(RAT) | BDBM86218
 (CAS_0 | Desmethylpiclamilas | NSC_0)Show InChI InChI=1S/C17H16Cl2N2O3/c18-12-8-20-9-13(19)16(12)21-17(23)10-5-6-14(22)15(7-10)24-11-3-1-2-4-11/h5-9,11,22H,1-4H2,(H,20,21,23) | PDB
Reactome pathway
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| 34.8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tennessee
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 305: 565-72 (2003)
Article DOI: 10.1124/jpet.102.47407 BindingDB Entry DOI: 10.7270/Q23B5XQG |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(RAT) | BDBM14773
 (4-cyano-4-(3-cyclopentyloxy-4-methoxy-phenyl)cyclo...)Show InChI InChI=1S/C20H25NO4/c1-24-17-7-6-15(12-18(17)25-16-4-2-3-5-16)20(13-21)10-8-14(9-11-20)19(22)23/h6-7,12,14,16H,2-5,8-11H2,1H3,(H,22,23) | PDB
Reactome pathway
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| 118 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tennessee
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 305: 565-72 (2003)
Article DOI: 10.1124/jpet.102.47407 BindingDB Entry DOI: 10.7270/Q23B5XQG |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(RAT) | BDBM50010981
 ((Ro 20-1724)4-(3-Butoxy-4-methoxy-benzyl)-imidazol...)Show InChI InChI=1S/C15H22N2O3/c1-3-4-7-20-14-9-11(5-6-13(14)19-2)8-12-10-16-15(18)17-12/h5-6,9,12H,3-4,7-8,10H2,1-2H3,(H2,16,17,18) | PDB
Reactome pathway
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| 189 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tennessee
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 305: 565-72 (2003)
Article DOI: 10.1124/jpet.102.47407 BindingDB Entry DOI: 10.7270/Q23B5XQG |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(RAT) | BDBM14773
 (4-cyano-4-(3-cyclopentyloxy-4-methoxy-phenyl)cyclo...)Show InChI InChI=1S/C20H25NO4/c1-24-17-7-6-15(12-18(17)25-16-4-2-3-5-16)20(13-21)10-8-14(9-11-20)19(22)23/h6-7,12,14,16H,2-5,8-11H2,1H3,(H,22,23) | PDB
Reactome pathway
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| 200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tennessee
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 305: 565-72 (2003)
Article DOI: 10.1124/jpet.102.47407 BindingDB Entry DOI: 10.7270/Q23B5XQG |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(RAT) | BDBM86222
 (CAS_62824 | ICI 63, 197 | NSC_62824)Show InChI InChI=1S/C9H13N5O/c1-3-4-13-7(15)6(2)5-14-9(13)11-8(10)12-14/h5H,3-4H2,1-2H3,(H2,10,12) | PDB
Reactome pathway
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| 313 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tennessee
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 305: 565-72 (2003)
Article DOI: 10.1124/jpet.102.47407 BindingDB Entry DOI: 10.7270/Q23B5XQG |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(RAT) | BDBM86218
 (CAS_0 | Desmethylpiclamilas | NSC_0)Show InChI InChI=1S/C17H16Cl2N2O3/c18-12-8-20-9-13(19)16(12)21-17(23)10-5-6-14(22)15(7-10)24-11-3-1-2-4-11/h5-9,11,22H,1-4H2,(H,20,21,23) | PDB
Reactome pathway
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| 600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tennessee
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 305: 565-72 (2003)
Article DOI: 10.1124/jpet.102.47407 BindingDB Entry DOI: 10.7270/Q23B5XQG |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(RAT) | BDBM50113382
 (4-(2-(3-(cyclopentyloxy)-4-methoxyphenyl)-2-phenyl...)Show InChI InChI=1S/C25H27NO2/c1-27-24-12-11-21(18-25(24)28-22-9-5-6-10-22)23(20-7-3-2-4-8-20)17-19-13-15-26-16-14-19/h2-4,7-8,11-16,18,22-23H,5-6,9-10,17H2,1H3 | PDB
Reactome pathway
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| 900 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tennessee
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 305: 565-72 (2003)
Article DOI: 10.1124/jpet.102.47407 BindingDB Entry DOI: 10.7270/Q23B5XQG |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(RAT) | BDBM14363
 (3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0...)Show InChI InChI=1S/C13H13N5O2/c1-2-7-20-9-6-4-3-5-8(9)11-14-12-10(13(19)15-11)16-18-17-12/h3-6H,2,7H2,1H3,(H2,14,15,16,17,18,19) | PDB
Reactome pathway
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| 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tennessee
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 305: 565-72 (2003)
Article DOI: 10.1124/jpet.102.47407 BindingDB Entry DOI: 10.7270/Q23B5XQG |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(RAT) | BDBM86220
 (CAS_443955 | NSC_443955 | Vinpocetine)Show SMILES CCOC(=O)C1=CC2(CC)CCCN3CCc4c(C23)n1c1ccccc41 Show InChI InChI=1S/C22H26N2O2/c1-3-22-11-7-12-23-13-10-16-15-8-5-6-9-17(15)24(19(16)20(22)23)18(14-22)21(25)26-4-2/h5-6,8-9,14,20H,3-4,7,10-13H2,1-2H3 | PDB
Reactome pathway
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| 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tennessee
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 305: 565-72 (2003)
Article DOI: 10.1124/jpet.102.47407 BindingDB Entry DOI: 10.7270/Q23B5XQG |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(RAT) | BDBM50113382
 (4-(2-(3-(cyclopentyloxy)-4-methoxyphenyl)-2-phenyl...)Show InChI InChI=1S/C25H27NO2/c1-27-24-12-11-21(18-25(24)28-22-9-5-6-10-22)23(20-7-3-2-4-8-20)17-19-13-15-26-16-14-19/h2-4,7-8,11-16,18,22-23H,5-6,9-10,17H2,1H3 | PDB
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| 1.25E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tennessee
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 305: 565-72 (2003)
Article DOI: 10.1124/jpet.102.47407 BindingDB Entry DOI: 10.7270/Q23B5XQG |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(RAT) | BDBM15336
 (1-methyl-3-(2-methylpropyl)-2,3,6,7-tetrahydro-1H-...)Show InChI InChI=1S/C10H14N4O2/c1-6(2)4-14-8-7(11-5-12-8)9(15)13(3)10(14)16/h5-6H,4H2,1-3H3,(H,11,12) | PDB
Reactome pathway
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| 3.09E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tennessee
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 305: 565-72 (2003)
Article DOI: 10.1124/jpet.102.47407 BindingDB Entry DOI: 10.7270/Q23B5XQG |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(RAT) | BDBM86219
 (CAS_5537 | NSC_5537 | Trequinsin)Show SMILES COc1cc2CCn3c(cc(=Nc4c(C)cc(C)cc4C)n(C)c3=O)-c2cc1OC Show InChI InChI=1S/C24H27N3O3/c1-14-9-15(2)23(16(3)10-14)25-22-13-19-18-12-21(30-6)20(29-5)11-17(18)7-8-27(19)24(28)26(22)4/h9-13H,7-8H2,1-6H3 | PDB
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| 3.15E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tennessee
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 305: 565-72 (2003)
Article DOI: 10.1124/jpet.102.47407 BindingDB Entry DOI: 10.7270/Q23B5XQG |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(RAT) | BDBM14361
 ((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18) | PDB
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| 4.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tennessee
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 305: 565-72 (2003)
Article DOI: 10.1124/jpet.102.47407 BindingDB Entry DOI: 10.7270/Q23B5XQG |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(RAT) | BDBM15336
 (1-methyl-3-(2-methylpropyl)-2,3,6,7-tetrahydro-1H-...)Show InChI InChI=1S/C10H14N4O2/c1-6(2)4-14-8-7(11-5-12-8)9(15)13(3)10(14)16/h5-6H,4H2,1-3H3,(H,11,12) | PDB
Reactome pathway
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| 8.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tennessee
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 305: 565-72 (2003)
Article DOI: 10.1124/jpet.102.47407 BindingDB Entry DOI: 10.7270/Q23B5XQG |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(RAT) | BDBM14754
 (1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-isoq...)Show InChI InChI=1S/C20H21NO4/c1-22-17-6-5-13(10-18(17)23-2)9-16-15-12-20(25-4)19(24-3)11-14(15)7-8-21-16/h5-8,10-12H,9H2,1-4H3 | PDB
Reactome pathway
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| 8.82E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tennessee
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 305: 565-72 (2003)
Article DOI: 10.1124/jpet.102.47407 BindingDB Entry DOI: 10.7270/Q23B5XQG |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(RAT) | BDBM86219
 (CAS_5537 | NSC_5537 | Trequinsin)Show SMILES COc1cc2CCn3c(cc(=Nc4c(C)cc(C)cc4C)n(C)c3=O)-c2cc1OC Show InChI InChI=1S/C24H27N3O3/c1-14-9-15(2)23(16(3)10-14)25-22-13-19-18-12-21(30-6)20(29-5)11-17(18)7-8-27(19)24(28)26(22)4/h9-13H,7-8H2,1-6H3 | PDB
Reactome pathway
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| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tennessee
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 305: 565-72 (2003)
Article DOI: 10.1124/jpet.102.47407 BindingDB Entry DOI: 10.7270/Q23B5XQG |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(RAT) | BDBM86222
 (CAS_62824 | ICI 63, 197 | NSC_62824)Show InChI InChI=1S/C9H13N5O/c1-3-4-13-7(15)6(2)5-14-9(13)11-8(10)12-14/h5H,3-4H2,1-2H3,(H2,10,12) | PDB
Reactome pathway
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| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tennessee
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 305: 565-72 (2003)
Article DOI: 10.1124/jpet.102.47407 BindingDB Entry DOI: 10.7270/Q23B5XQG |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(RAT) | BDBM15296
 (6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...)Show InChI InChI=1S/C12H9N3O/c1-8-11(9-2-4-14-5-3-9)6-10(7-13)12(16)15-8/h2-6H,1H3,(H,15,16) | PDB
Reactome pathway
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| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tennessee
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 305: 565-72 (2003)
Article DOI: 10.1124/jpet.102.47407 BindingDB Entry DOI: 10.7270/Q23B5XQG |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(RAT) | BDBM15296
 (6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...)Show InChI InChI=1S/C12H9N3O/c1-8-11(9-2-4-14-5-3-9)6-10(7-13)12(16)15-8/h2-6H,1H3,(H,15,16) | PDB
Reactome pathway
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| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tennessee
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 305: 565-72 (2003)
Article DOI: 10.1124/jpet.102.47407 BindingDB Entry DOI: 10.7270/Q23B5XQG |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(RAT) | BDBM14754
 (1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-isoq...)Show InChI InChI=1S/C20H21NO4/c1-22-17-6-5-13(10-18(17)23-2)9-16-15-12-20(25-4)19(24-3)11-14(15)7-8-21-16/h5-8,10-12H,9H2,1-4H3 | PDB
Reactome pathway
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| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tennessee
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 305: 565-72 (2003)
Article DOI: 10.1124/jpet.102.47407 BindingDB Entry DOI: 10.7270/Q23B5XQG |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(RAT) | BDBM50010981
 ((Ro 20-1724)4-(3-Butoxy-4-methoxy-benzyl)-imidazol...)Show InChI InChI=1S/C15H22N2O3/c1-3-4-7-20-14-9-11(5-6-13(14)19-2)8-12-10-16-15(18)17-12/h5-6,9,12H,3-4,7-8,10H2,1-2H3,(H2,16,17,18) | PDB
Reactome pathway
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| Article PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tennessee
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 305: 565-72 (2003)
Article DOI: 10.1124/jpet.102.47407 BindingDB Entry DOI: 10.7270/Q23B5XQG |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(RAT) | BDBM50017294
 (CHEMBL3288029)Show SMILES C[C@H]1CN(Cc2ccc(c(CN3CCOCC3)c2)-c2cccc(Oc3ncc(F)cc3C(=O)N[C@@H]3CC[C@@H](CC3)NC(=O)c3nc(C)cs3)c2)C[C@@H](C)N1 Show InChI InChI=1S/C41H50FN7O4S/c1-26-21-49(22-27(2)44-26)23-29-7-12-36(31(17-29)24-48-13-15-52-16-14-48)30-5-4-6-35(18-30)53-40-37(19-32(42)20-43-40)38(50)46-33-8-10-34(11-9-33)47-39(51)41-45-28(3)25-54-41/h4-7,12,17-20,25-27,33-34,44H,8-11,13-16,21-24H2,1-3H3,(H,46,50)(H,47,51)/t26-,27+,33-,34+ | PDB
Reactome pathway
UniProtKB/SwissProt
GoogleScholar
| CHEMBL PC cid PC sid UniChem
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| Article PubMed
| n/a | n/a | 0.0200 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of rat PDE4B |
J Med Chem 57: 4661-76 (2014)
Article DOI: 10.1021/jm5001216 BindingDB Entry DOI: 10.7270/Q2708302 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(RAT) | BDBM50017295
 (CHEMBL3288030)Show SMILES C[C@H]1CN(Cc2ccc(c(CN3CCOCC3)c2)-c2cccc(Oc3ncc(F)cc3C(=O)N[C@@H]3CC[C@@H](CC3)NC(=O)c3cc(C)ccc3O)c2)C[C@@H](C)N1 Show InChI InChI=1S/C44H53FN6O5/c1-28-7-14-41(52)39(19-28)42(53)48-35-9-11-36(12-10-35)49-43(54)40-22-34(45)23-46-44(40)56-37-6-4-5-32(21-37)38-13-8-31(26-51-24-29(2)47-30(3)25-51)20-33(38)27-50-15-17-55-18-16-50/h4-8,13-14,19-23,29-30,35-36,47,52H,9-12,15-18,24-27H2,1-3H3,(H,48,53)(H,49,54)/t29-,30+,35-,36+ | PDB
Reactome pathway
UniProtKB/SwissProt
GoogleScholar
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.0251 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of rat PDE4B |
J Med Chem 57: 4661-76 (2014)
Article DOI: 10.1021/jm5001216 BindingDB Entry DOI: 10.7270/Q2708302 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM285634
 (3-(4-chloro-3,5-difluoro-phenyl)-N-cyclopropyl-imi...)Show SMILES Fc1cc(cc(F)c1Cl)-c1c(nc2cccnn12)C(=O)NC1CC1 Show InChI InChI=1S/C16H11ClF2N4O/c17-13-10(18)6-8(7-11(13)19)15-14(16(24)21-9-3-4-9)22-12-2-1-5-20-23(12)15/h1-2,5-7,9H,3-4H2,(H,21,24) | PDB
GoogleScholar
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 1.59 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
US Patent
| Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD... |
US Patent US10077269 (2018)
BindingDB Entry DOI: 10.7270/Q2P84DX5 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM285538
 (N-cyclopropyl-3-(3,4-di-chlorophenyl)imidazo[1,2-b...)Show InChI InChI=1S/C16H12Cl2N4O/c17-11-6-3-9(8-12(11)18)15-14(16(23)20-10-4-5-10)21-13-2-1-7-19-22(13)15/h1-3,6-8,10H,4-5H2,(H,20,23) | PDB
GoogleScholar
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
US Patent
| Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD... |
US Patent US10077269 (2018)
BindingDB Entry DOI: 10.7270/Q2P84DX5 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM285534
 (3-(4-Chloro-3-fluorophenyl)-N-(1-methyl-1H-pyrazol...)Show SMILES Cn1cc(NC(=O)c2nc3cccnn3c2-c2ccc(Cl)c(F)c2)cn1 Show InChI InChI=1S/C17H12ClFN6O/c1-24-9-11(8-21-24)22-17(26)15-16(10-4-5-12(18)13(19)7-10)25-14(23-15)3-2-6-20-25/h2-9H,1H3,(H,22,26) | PDB
GoogleScholar
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <1.89 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
US Patent
| Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD... |
US Patent US10077269 (2018)
BindingDB Entry DOI: 10.7270/Q2P84DX5 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM285572
 (3-(4-chloro-3-fluorophenyl)-N-[(1R,2S)-2-fluorocyc...)Show SMILES F[C@H]1C[C@H]1NC(=O)c1nc2cccnn2c1-c1ccc(Cl)c(F)c1 Show InChI InChI=1S/C16H11ClF2N4O/c17-9-4-3-8(6-10(9)18)15-14(16(24)21-12-7-11(12)19)22-13-2-1-5-20-23(13)15/h1-6,11-12H,7H2,(H,21,24)/t11-,12+/m0/s1 | PDB
GoogleScholar
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 1.97 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
US Patent
| Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD... |
US Patent US10077269 (2018)
BindingDB Entry DOI: 10.7270/Q2P84DX5 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(RAT) | BDBM50450770
 (CHEMBL320307)Show SMILES COc1cccc(COc2cccc(c2)N2CC(CC2=O)c2ccc(OC)c(OC3CCCC3)c2)c1 Show InChI InChI=1S/C30H33NO5/c1-33-26-11-5-7-21(15-26)20-35-27-12-6-8-24(18-27)31-19-23(17-30(31)32)22-13-14-28(34-2)29(16-22)36-25-9-3-4-10-25/h5-8,11-16,18,23,25H,3-4,9-10,17,19-20H2,1-2H3 | PDB
Reactome pathway
UniProtKB/SwissProt
GoogleScholar
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.51 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Horsham Research Center
Curated by ChEMBL
| Assay Description Inhibition of phosphodiesterase (PDE) 4B |
Bioorg Med Chem Lett 8: 3229-34 (1999)
Article DOI: 10.1016/s0960-894x(98)00583-6 BindingDB Entry DOI: 10.7270/Q2ZS2Z11 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM285598
 (3-(3-chloro-4-methylphenyl)-N-[(1R,2S)-2-fluorocyc...)Show SMILES Cc1ccc(cc1Cl)-c1c(nc2cccnn12)C(=O)N[C@@H]1C[C@@H]1F Show InChI InChI=1S/C17H14ClFN4O/c1-9-4-5-10(7-11(9)18)16-15(17(24)21-13-8-12(13)19)22-14-3-2-6-20-23(14)16/h2-7,12-13H,8H2,1H3,(H,21,24)/t12-,13+/m0/s1 | PDB
GoogleScholar
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 2.82 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
US Patent
| Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD... |
US Patent US10077269 (2018)
BindingDB Entry DOI: 10.7270/Q2P84DX5 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM285537
 (3-(4-chloro-3-fluoro-phenyl)-N-cyclopropyl-imidazo...)Show InChI InChI=1S/C16H12ClFN4O/c17-11-6-3-9(8-12(11)18)15-14(16(23)20-10-4-5-10)21-13-2-1-7-19-22(13)15/h1-3,6-8,10H,4-5H2,(H,20,23) | PDB
GoogleScholar
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 3.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
US Patent
| Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD... |
US Patent US10077269 (2018)
BindingDB Entry DOI: 10.7270/Q2P84DX5 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM285574
 (US10077269, Example 47 | US9598421, Example 47 | a...)Show SMILES Fc1cc(cc(F)c1Cl)-c1c(nc2cccnn12)C(=O)N1CCC1 Show InChI InChI=1S/C16H11ClF2N4O/c17-13-10(18)7-9(8-11(13)19)15-14(16(24)22-5-2-6-22)21-12-3-1-4-20-23(12)15/h1,3-4,7-8H,2,5-6H2 | PDB
GoogleScholar
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 3.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
US Patent
| Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD... |
US Patent US10077269 (2018)
BindingDB Entry DOI: 10.7270/Q2P84DX5 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM285571
 (3-(4-chloro-3-fluorophenyl)-N-(2,2-difluorocyclopr...)Show SMILES Fc1cc(ccc1Cl)-c1c(nc2cccnn12)C(=O)NC1CC1(F)F Show InChI InChI=1S/C16H10ClF3N4O/c17-9-4-3-8(6-10(9)18)14-13(15(25)22-11-7-16(11,19)20)23-12-2-1-5-21-24(12)14/h1-6,11H,7H2,(H,22,25) | PDB
GoogleScholar
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 3.92 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
US Patent
| Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD... |
US Patent US10077269 (2018)
BindingDB Entry DOI: 10.7270/Q2P84DX5 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM285540
 (US10077269, Example 13 | US9598421, Example 13 | a...)Show InChI InChI=1S/C16H12ClFN4O/c17-11-5-4-10(9-12(11)18)15-14(16(23)21-7-2-8-21)20-13-3-1-6-19-22(13)15/h1,3-6,9H,2,7-8H2 | PDB
GoogleScholar
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 4.63 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
US Patent
| Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD... |
US Patent US10077269 (2018)
BindingDB Entry DOI: 10.7270/Q2P84DX5 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(RAT) | BDBM50450771
 (CHEMBL326655)Show SMILES COc1cccc(COc2cc(cc(c2)C(=O)NN(C)C)N2CC(CC2=O)c2ccc(OC)c(OC3CCCC3)c2)c1 Show InChI InChI=1S/C33H39N3O6/c1-35(2)34-33(38)24-15-26(19-29(16-24)41-21-22-8-7-11-28(14-22)39-3)36-20-25(18-32(36)37)23-12-13-30(40-4)31(17-23)42-27-9-5-6-10-27/h7-8,11-17,19,25,27H,5-6,9-10,18,20-21H2,1-4H3,(H,34,38) | PDB
Reactome pathway
UniProtKB/SwissProt
GoogleScholar
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5.01 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Horsham Research Center
Curated by ChEMBL
| Assay Description Inhibition of phosphodiesterase (PDE) 4B |
Bioorg Med Chem Lett 8: 3229-34 (1999)
Article DOI: 10.1016/s0960-894x(98)00583-6 BindingDB Entry DOI: 10.7270/Q2ZS2Z11 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM285556
 (3-(4-chloro-3-fluorophenyl)-N-propylimidazo[1,2-b]...)Show InChI InChI=1S/C16H14ClFN4O/c1-2-7-19-16(23)14-15(10-5-6-11(17)12(18)9-10)22-13(21-14)4-3-8-20-22/h3-6,8-9H,2,7H2,1H3,(H,19,23) | PDB
GoogleScholar
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 5.05 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
US Patent
| Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD... |
US Patent US10077269 (2018)
BindingDB Entry DOI: 10.7270/Q2P84DX5 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM285612
 (3-(4-chloro-3-fluorophenyl)-N-(1H-pyrazol-4-yl)imi...)Show SMILES Fc1cc(ccc1Cl)-c1c(nc2cccnn12)C(=O)Nc1cn[nH]c1 Show InChI InChI=1S/C16H10ClFN6O/c17-11-4-3-9(6-12(11)18)15-14(16(25)22-10-7-19-20-8-10)23-13-2-1-5-21-24(13)15/h1-8H,(H,19,20)(H,22,25) | PDB
GoogleScholar
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 5.14 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
US Patent
| Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD... |
US Patent US10077269 (2018)
BindingDB Entry DOI: 10.7270/Q2P84DX5 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM285613
 (US10077269, Example 83 | US9598421, Example 83 | a...)Show InChI InChI=1S/C16H12Cl2N4O/c17-11-5-4-10(9-12(11)18)15-14(16(23)21-7-2-8-21)20-13-3-1-6-19-22(13)15/h1,3-6,9H,2,7-8H2 | PDB
GoogleScholar
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 5.39 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
US Patent
| Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD... |
US Patent US10077269 (2018)
BindingDB Entry DOI: 10.7270/Q2P84DX5 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM285603
 (US10077269, Example 76 | US9598421, Example 76 | a...)Show SMILES FC(F)Oc1cc(ccn1)-c1c(nc2cccnn12)C(=O)N1CCC1 Show InChI InChI=1S/C16H13F2N5O2/c17-16(18)25-12-9-10(4-6-19-12)14-13(15(24)22-7-2-8-22)21-11-3-1-5-20-23(11)14/h1,3-6,9,16H,2,7-8H2 | PDB
GoogleScholar
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 5.43 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
US Patent
| Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD... |
US Patent US10077269 (2018)
BindingDB Entry DOI: 10.7270/Q2P84DX5 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM285547
 (4-[2-(azetidin-1-ylcarbonyl)imidazo[1,2-b]pyridazi...)Show SMILES Cc1cc(C#N)c(F)cc1-c1c(nc2cccnn12)C(=O)N1CCC1 Show InChI InChI=1S/C18H14FN5O/c1-11-8-12(10-20)14(19)9-13(11)17-16(18(25)23-6-3-7-23)22-15-4-2-5-21-24(15)17/h2,4-5,8-9H,3,6-7H2,1H3 | PDB
GoogleScholar
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 5.74 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
US Patent
| Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD... |
US Patent US10077269 (2018)
BindingDB Entry DOI: 10.7270/Q2P84DX5 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM285602
 (N-cyclopropyl-3-[2-(difluoro-methoxy)pyridin-4-yl]...)Show SMILES FC(F)Oc1cc(ccn1)-c1c(nc2cccnn12)C(=O)NC1CC1 Show InChI InChI=1S/C16H13F2N5O2/c17-16(18)25-12-8-9(5-7-19-12)14-13(15(24)21-10-3-4-10)22-11-2-1-6-20-23(11)14/h1-2,5-8,10,16H,3-4H2,(H,21,24) | PDB
GoogleScholar
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 5.99 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
US Patent
| Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD... |
US Patent US10077269 (2018)
BindingDB Entry DOI: 10.7270/Q2P84DX5 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM285563
 (3-(3-chlorophenyl)-N-cyclopropylimidazo[1,2-b]pyri...)Show InChI InChI=1S/C16H13ClN4O/c17-11-4-1-3-10(9-11)15-14(16(22)19-12-6-7-12)20-13-5-2-8-18-21(13)15/h1-5,8-9,12H,6-7H2,(H,19,22) | PDB
GoogleScholar
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 6.99 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
US Patent
| Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD... |
US Patent US10077269 (2018)
BindingDB Entry DOI: 10.7270/Q2P84DX5 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM285616
 (US10077269, Example 86 | US9598421, Example 86 | a...)Show SMILES FC1(F)Oc2ccc(cc2O1)-c1c(nc2cccnn12)C(=O)N1CCC1 Show InChI InChI=1S/C17H12F2N4O3/c18-17(19)25-11-5-4-10(9-12(11)26-17)15-14(16(24)22-7-2-8-22)21-13-3-1-6-20-23(13)15/h1,3-6,9H,2,7-8H2 | PDB
GoogleScholar
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 7.72 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
US Patent
| Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD... |
US Patent US10077269 (2018)
BindingDB Entry DOI: 10.7270/Q2P84DX5 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM285614
 (US10077269, Example 84 | US9598421, Example 84 | a...)Show InChI InChI=1S/C16H13ClN4O/c17-12-5-1-4-11(10-12)15-14(16(22)20-8-3-9-20)19-13-6-2-7-18-21(13)15/h1-2,4-7,10H,3,8-9H2 | PDB
GoogleScholar
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 7.84 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
US Patent
| Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD... |
US Patent US10077269 (2018)
BindingDB Entry DOI: 10.7270/Q2P84DX5 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM285568
 (N-cyclopropyl-3-(3-fluoro-4-methylphenyl)imidazo[1...)Show InChI InChI=1S/C17H15FN4O/c1-10-4-5-11(9-13(10)18)16-15(17(23)20-12-6-7-12)21-14-3-2-8-19-22(14)16/h2-5,8-9,12H,6-7H2,1H3,(H,20,23) | PDB
GoogleScholar
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 8.05 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
US Patent
| Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD... |
US Patent US10077269 (2018)
BindingDB Entry DOI: 10.7270/Q2P84DX5 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM285611
 (3-(4-chloro-3-fluorophenyl)-N-ethylimidazo[1,2-b]p...)Show InChI InChI=1S/C15H12ClFN4O/c1-2-18-15(22)13-14(9-5-6-10(16)11(17)8-9)21-12(20-13)4-3-7-19-21/h3-8H,2H2,1H3,(H,18,22) | PDB
GoogleScholar
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 9.34 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
US Patent
| Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD... |
US Patent US10077269 (2018)
BindingDB Entry DOI: 10.7270/Q2P84DX5 |
More data for this Ligand-Target Pair | |