Compile Data Set for Download or QSAR

Found 1740 hits Enz. Inhib. hit(s) with Target = 'cAMP-specific 3',5'-cyclic phosphodiesterase 4B'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM14381 (4-{2-[6-Amino-3-(3-cyclopentyloxy-4-methoxy-benzyl...) Show SMILES COC(=O)c1ccc(COC(C)(C)c2nc3c(N)ncn(Cc4ccc(OC)c(OC5CCCC5)c4)c3n2)cc1 Show InChI InChI=1S/C30H35N5O5/c1-30(2,39-17-19-9-12-21(13-10-19)28(36)38-4)29-33-25-26(31)32-18-35(27(25)34-29)16-20-11-14-23(37-3)24(15-20)40-22-7-5-6-8-22/h9-15,18,22H,5-8,16-17,31H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar	PC cid PC sid UniChem Similars	Article PubMed	5.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Purdue Pharma LP					Assay Description PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...				J Med Chem 48: 1237-43 (2005) Article DOI: 10.1021/jm030603w BindingDB Entry DOI: 10.7270/Q2GT5KF0
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50314557 ((4-(3-(4-(3-nitrophenyl)pyridazino[4,5-b]indolizin...) Show SMILES [O-][N+](=O)c1cccc(c1)-c1nnc(NCCCN2CCN(CC2)C(=O)c2cnccn2)c2cc3ccccn3c12 Show InChI InChI=1S/C28H27N9O3/c38-28(24-19-29-9-10-30-24)35-15-13-34(14-16-35)11-4-8-31-27-23-18-21-6-1-2-12-36(21)26(23)25(32-33-27)20-5-3-7-22(17-20)37(39)40/h1-3,5-7,9-10,12,17-19H,4,8,11,13-16H2,(H,31,33)	PDB UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	5.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Displacement of [methyl-3H]rolipram from PDE4B3 expressed in CHO cells after 1 hr by scintillation counting				Bioorg Med Chem Lett 20: 2163-7 (2010) Article DOI: 10.1016/j.bmcl.2010.02.044 BindingDB Entry DOI: 10.7270/Q2NK3F54
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM14379 (3-(3-Cyclopentyloxy-4-methoxy-benzyl)-8-[1-(4-tert...) Show SMILES COc1ccc(Cn2cnc(N)c3nc(nc23)C(C)(C)OCc2ccc(cc2)C(C)(C)C)cc1OC1CCCC1 Show InChI InChI=1S/C32H41N5O3/c1-31(2,3)23-14-11-21(12-15-23)19-39-32(4,5)30-35-27-28(33)34-20-37(29(27)36-30)18-22-13-16-25(38-6)26(17-22)40-24-9-7-8-10-24/h11-17,20,24H,7-10,18-19,33H2,1-6H3	PDB UniProtKB/SwissProt GoogleScholar	PC cid PC sid UniChem Similars	Article PubMed	5.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Purdue Pharma LP					Assay Description PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...				J Med Chem 48: 1237-43 (2005) Article DOI: 10.1021/jm030603w BindingDB Entry DOI: 10.7270/Q2GT5KF0
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM14382 (4-{2-[6-Amino-3-(3-cyclopentyloxy-4-methoxy-benzyl...) Show SMILES COc1ccc(Cn2cnc(N)c3nc(nc23)C(C)(C)OCc2ccc(cc2)C(N)=O)cc1OC1CCCC1 Show InChI InChI=1S/C29H34N6O4/c1-29(2,38-16-18-8-11-20(12-9-18)26(31)36)28-33-24-25(30)32-17-35(27(24)34-28)15-19-10-13-22(37-3)23(14-19)39-21-6-4-5-7-21/h8-14,17,21H,4-7,15-16,30H2,1-3H3,(H2,31,36)	PDB UniProtKB/SwissProt GoogleScholar	PC cid PC sid UniChem Similars	Article PubMed	7.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Purdue Pharma LP					Assay Description PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...				J Med Chem 48: 1237-43 (2005) Article DOI: 10.1021/jm030603w BindingDB Entry DOI: 10.7270/Q2GT5KF0
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM14365 (8-(1-Benzyloxy-1-methyl-ethyl)-3-(3-cyclopentyloxy...) Show SMILES COc1ccc(Cn2cnc(N)c3nc(nc23)C(C)(C)OCc2ccccc2)cc1OC1CCCC1 Show InChI InChI=1S/C28H33N5O3/c1-28(2,35-17-19-9-5-4-6-10-19)27-31-24-25(29)30-18-33(26(24)32-27)16-20-13-14-22(34-3)23(15-20)36-21-11-7-8-12-21/h4-6,9-10,13-15,18,21H,7-8,11-12,16-17,29H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar	PC cid PC sid UniChem Similars	Article PubMed	8.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Purdue Pharma LP					Assay Description PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...				J Med Chem 48: 1237-43 (2005) Article DOI: 10.1021/jm030603w BindingDB Entry DOI: 10.7270/Q2GT5KF0
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM14386 (3-(3-Cyclopentyloxy-4-methoxy-benzyl)-8-[1,1-dimet...) Show SMILES COc1ccc(Cn2cnc(N)c3nc(nc23)C(C)(C)COc2ccsc2)cc1OC1CCCC1 Show InChI InChI=1S/C26H31N5O3S/c1-26(2,15-33-19-10-11-35-14-19)25-29-22-23(27)28-16-31(24(22)30-25)13-17-8-9-20(32-3)21(12-17)34-18-6-4-5-7-18/h8-12,14,16,18H,4-7,13,15,27H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar	PC cid PC sid UniChem Similars	Article PubMed	9.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Purdue Pharma LP					Assay Description PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...				J Med Chem 48: 1237-43 (2005) Article DOI: 10.1021/jm030603w BindingDB Entry DOI: 10.7270/Q2GT5KF0
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM14378 (3-(3-Cyclopentyloxy-4-methoxy-benzyl)-8-[1-(3,4-di...) Show SMILES COc1ccc(Cn2cnc(N)c3nc(nc23)C(C)(C)OCc2ccc(Cl)c(Cl)c2)cc1OC1CCCC1 Show InChI InChI=1S/C28H31Cl2N5O3/c1-28(2,37-15-18-8-10-20(29)21(30)12-18)27-33-24-25(31)32-16-35(26(24)34-27)14-17-9-11-22(36-3)23(13-17)38-19-6-4-5-7-19/h8-13,16,19H,4-7,14-15,31H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar	PC cid PC sid UniChem Similars	Article PubMed	9.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Purdue Pharma LP					Assay Description PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...				J Med Chem 48: 1237-43 (2005) Article DOI: 10.1021/jm030603w BindingDB Entry DOI: 10.7270/Q2GT5KF0
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM14369 (3-(3-Cyclopentyloxy-4-methoxy-benzyl)-8-[1-(4-meth...) Show SMILES COc1ccc(Cn2cnc(N)c3nc(nc23)C(C)(C)OCc2ccc(C)cc2)cc1OC1CCCC1 Show InChI InChI=1S/C29H35N5O3/c1-19-9-11-20(12-10-19)17-36-29(2,3)28-32-25-26(30)31-18-34(27(25)33-28)16-21-13-14-23(35-4)24(15-21)37-22-7-5-6-8-22/h9-15,18,22H,5-8,16-17,30H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar	PC cid PC sid UniChem Similars	Article PubMed	9.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Purdue Pharma LP					Assay Description PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...				J Med Chem 48: 1237-43 (2005) Article DOI: 10.1021/jm030603w BindingDB Entry DOI: 10.7270/Q2GT5KF0
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM14368 (3-(3-Cyclopentyloxy-4-methoxy-benzyl)-8-[1-(4-meth...) Show SMILES COc1ccc(COC(C)(C)c2nc3c(N)ncn(Cc4ccc(OC)c(OC5CCCC5)c4)c3n2)cc1 Show InChI InChI=1S/C29H35N5O4/c1-29(2,37-17-19-9-12-21(35-3)13-10-19)28-32-25-26(30)31-18-34(27(25)33-28)16-20-11-14-23(36-4)24(15-20)38-22-7-5-6-8-22/h9-15,18,22H,5-8,16-17,30H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar	PC cid PC sid UniChem Similars	Article PubMed	10.3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Purdue Pharma LP					Assay Description PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...				J Med Chem 48: 1237-43 (2005) Article DOI: 10.1021/jm030603w BindingDB Entry DOI: 10.7270/Q2GT5KF0
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM14370 (8-{1-[(4-Chlorobenzyl)oxy]-1-methyl-ethyl}-3-[3-cy...) Show SMILES COc1ccc(Cn2cnc(N)c3nc(nc23)C(C)(C)OCc2ccc(Cl)cc2)cc1OC1CCCC1 Show InChI InChI=1S/C28H32ClN5O3/c1-28(2,36-16-18-8-11-20(29)12-9-18)27-32-24-25(30)31-17-34(26(24)33-27)15-19-10-13-22(35-3)23(14-19)37-21-6-4-5-7-21/h8-14,17,21H,4-7,15-16,30H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar	PC cid PC sid UniChem Similars	Article PubMed	11	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Purdue Pharma LP					Assay Description PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...				J Med Chem 48: 1237-43 (2005) Article DOI: 10.1021/jm030603w BindingDB Entry DOI: 10.7270/Q2GT5KF0
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM14366 (3-(3-Cyclopentyloxy-4-methoxy-benzyl)-8-[1-(2-meth...) Show SMILES COc1ccccc1COC(C)(C)c1nc2c(N)ncn(Cc3ccc(OC)c(OC4CCCC4)c3)c2n1 Show InChI InChI=1S/C29H35N5O4/c1-29(2,37-17-20-9-5-8-12-22(20)35-3)28-32-25-26(30)31-18-34(27(25)33-28)16-19-13-14-23(36-4)24(15-19)38-21-10-6-7-11-21/h5,8-9,12-15,18,21H,6-7,10-11,16-17,30H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar	PC cid PC sid UniChem Similars	Article PubMed	11	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Purdue Pharma LP					Assay Description PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...				J Med Chem 48: 1237-43 (2005) Article DOI: 10.1021/jm030603w BindingDB Entry DOI: 10.7270/Q2GT5KF0
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM14372 (3-(3-Cyclopentyloxy-4-methoxy-benzyl)-8-[1-(3-fluo...) Show SMILES COc1ccc(Cn2cnc(N)c3nc(nc23)C(C)(C)OCc2cccc(F)c2)cc1OC1CCCC1 Show InChI InChI=1S/C28H32FN5O3/c1-28(2,36-16-19-7-6-8-20(29)13-19)27-32-24-25(30)31-17-34(26(24)33-27)15-18-11-12-22(35-3)23(14-18)37-21-9-4-5-10-21/h6-8,11-14,17,21H,4-5,9-10,15-16,30H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar	PC cid PC sid UniChem Patents Similars	Article PubMed	11.6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Purdue Pharma LP					Assay Description PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...				J Med Chem 48: 1237-43 (2005) Article DOI: 10.1021/jm030603w BindingDB Entry DOI: 10.7270/Q2GT5KF0
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM14367 (3-(3-Cyclopentyloxy-4-methoxy-benzyl)-8-[1-(3-meth...) Show SMILES COc1cccc(COC(C)(C)c2nc3c(N)ncn(Cc4ccc(OC)c(OC5CCCC5)c4)c3n2)c1 Show InChI InChI=1S/C29H35N5O4/c1-29(2,37-17-20-8-7-11-22(14-20)35-3)28-32-25-26(30)31-18-34(27(25)33-28)16-19-12-13-23(36-4)24(15-19)38-21-9-5-6-10-21/h7-8,11-15,18,21H,5-6,9-10,16-17,30H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar	PC cid PC sid UniChem Similars	Article PubMed	13	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Purdue Pharma LP					Assay Description PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...				J Med Chem 48: 1237-43 (2005) Article DOI: 10.1021/jm030603w BindingDB Entry DOI: 10.7270/Q2GT5KF0
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM14375 ((2E)-but-2-enedioic acid; 3-{[3-(cyclopentyloxy)-4...) Show SMILES COc1ccc(Cn2cnc(N)c3nc(nc23)C(C)(C)OCc2ccc(F)c(F)c2)cc1OC1CCCC1 Show InChI InChI=1S/C28H31F2N5O3/c1-28(2,37-15-18-8-10-20(29)21(30)12-18)27-33-24-25(31)32-16-35(26(24)34-27)14-17-9-11-22(36-3)23(13-17)38-19-6-4-5-7-19/h8-13,16,19H,4-7,14-15,31H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar	PC cid PC sid UniChem Similars	Article PubMed	17.3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Purdue Pharma LP					Assay Description PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...				J Med Chem 48: 1237-43 (2005) Article DOI: 10.1021/jm030603w BindingDB Entry DOI: 10.7270/Q2GT5KF0
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM14371 (3-(3-Cyclopentyloxy-4-methoxy-benzyl)-8-[1-(2-fluo...) Show SMILES COc1ccc(Cn2cnc(N)c3nc(nc23)C(C)(C)OCc2ccccc2F)cc1OC1CCCC1 Show InChI InChI=1S/C28H32FN5O3/c1-28(2,36-16-19-8-4-7-11-21(19)29)27-32-24-25(30)31-17-34(26(24)33-27)15-18-12-13-22(35-3)23(14-18)37-20-9-5-6-10-20/h4,7-8,11-14,17,20H,5-6,9-10,15-16,30H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar	PC cid PC sid UniChem Patents Similars	Article PubMed	18.9	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Purdue Pharma LP					Assay Description PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...				J Med Chem 48: 1237-43 (2005) Article DOI: 10.1021/jm030603w BindingDB Entry DOI: 10.7270/Q2GT5KF0
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM14376 (3-(3-Cyclopentyloxy-4-methoxy-benzyl)-8-[1-(3,4-me...) Show SMILES COc1ccc(Cn2cnc(N)c3nc(nc23)C(C)(C)OCc2ccc3OCOc3c2)cc1OC1CCCC1 Show InChI InChI=1S/C29H33N5O5/c1-29(2,38-15-19-9-11-22-23(13-19)37-17-36-22)28-32-25-26(30)31-16-34(27(25)33-28)14-18-8-10-21(35-3)24(12-18)39-20-6-4-5-7-20/h8-13,16,20H,4-7,14-15,17,30H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar	PC cid PC sid UniChem Patents Similars	Article PubMed	21.4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Purdue Pharma LP					Assay Description PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...				J Med Chem 48: 1237-43 (2005) Article DOI: 10.1021/jm030603w BindingDB Entry DOI: 10.7270/Q2GT5KF0
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM14374 ((2E)-but-2-enedioic acid; 3-{[3-(cyclopentyloxy)-4...) Show SMILES COc1cc(COC(C)(C)c2nc3c(N)ncn(Cc4ccc(OC)c(OC5CCCC5)c4)c3n2)cc(OC)c1 Show InChI InChI=1S/C30H37N5O5/c1-30(2,39-17-20-12-22(36-3)15-23(13-20)37-4)29-33-26-27(31)32-18-35(28(26)34-29)16-19-10-11-24(38-5)25(14-19)40-21-8-6-7-9-21/h10-15,18,21H,6-9,16-17,31H2,1-5H3	PDB UniProtKB/SwissProt GoogleScholar	PC cid PC sid UniChem Similars	Article PubMed	21.9	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Purdue Pharma LP					Assay Description PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...				J Med Chem 48: 1237-43 (2005) Article DOI: 10.1021/jm030603w BindingDB Entry DOI: 10.7270/Q2GT5KF0
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM14380 (3-(3-Cyclopentyloxy-4-methoxy-benzyl)-8-[1-(4-trif...) Show SMILES COc1ccc(Cn2cnc(N)c3nc(nc23)C(C)(C)OCc2ccc(OC(F)(F)F)cc2)cc1OC1CCCC1 Show InChI InChI=1S/C29H32F3N5O4/c1-28(2,39-16-18-8-11-21(12-9-18)41-29(30,31)32)27-35-24-25(33)34-17-37(26(24)36-27)15-19-10-13-22(38-3)23(14-19)40-20-6-4-5-7-20/h8-14,17,20H,4-7,15-16,33H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar	PC cid PC sid UniChem Similars	Article PubMed	26.6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Purdue Pharma LP					Assay Description PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...				J Med Chem 48: 1237-43 (2005) Article DOI: 10.1021/jm030603w BindingDB Entry DOI: 10.7270/Q2GT5KF0
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50029954 ((7R,7aS)-7-(3-Cyclopentyloxy-4-methoxy-phenyl)-hex...) Show SMILES COc1ccc(cc1OC1CCCC1)[C@H]1CCN2[C@@H]1CNC2=O Show InChI InChI=1S/C18H24N2O3/c1-22-16-7-6-12(10-17(16)23-13-4-2-3-5-13)14-8-9-20-15(14)11-19-18(20)21/h6-7,10,13-15H,2-5,8-9,11H2,1H3,(H,19,21)/t14-,15-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	27	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Glaxo Wellcome Research Curated by ChEMBL					Assay Description Inhibition of human Phosphodiesterase 4B				J Med Chem 38: 4848-54 (1996) Article DOI: 10.1021/jm00024a012 BindingDB Entry DOI: 10.7270/Q2DZ079X
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50048248 ((3S,4R)-3-Acetyl-4-(3-cyclopentyloxy-4-methoxy-phe...) Show SMILES COC(=O)N1C[C@H]([C@@H](C1)c1ccc(OC)c(OC2CCCC2)c1)C(C)=O Show InChI InChI=1S/C20H27NO5/c1-13(22)16-11-21(20(23)25-3)12-17(16)14-8-9-18(24-2)19(10-14)26-15-6-4-5-7-15/h8-10,15-17H,4-7,11-12H2,1-3H3/t16-,17-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article	30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Ability to inhibit the catalytic activity of human Phosphodiesterase 4B (PDE IVB)				Bioorg Med Chem Lett 5: 1977-1982 (1995) Article DOI: 10.1016/0960-894X(95)00336-R BindingDB Entry DOI: 10.7270/Q2PN95MX
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50285059 (1-(tert-butyl) 3-methyl 4-(3-cyclopentyloxy-4-meth...) Show SMILES COC(=O)[C@@H]1CN(C[C@H]1c1ccc(OC)c(OC2CCCC2)c1)C(=O)OC(C)(C)C Show InChI InChI=1S/C23H33NO6/c1-23(2,3)30-22(26)24-13-17(18(14-24)21(25)28-5)15-10-11-19(27-4)20(12-15)29-16-8-6-7-9-16/h10-12,16-18H,6-9,13-14H2,1-5H3/t17-,18+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article	30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Ability to inhibit the catalytic activity of human Phosphodiesterase 4B (PDE IVB)				Bioorg Med Chem Lett 5: 1977-1982 (1995) Article DOI: 10.1016/0960-894X(95)00336-R BindingDB Entry DOI: 10.7270/Q2PN95MX
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM14384 (3-(3-Cyclopentyloxy-4-methoxy-benzyl)-8-[1-(4-trif...) Show SMILES COc1ccc(Cn2cnc(N)c3nc(nc23)C(C)(C)OCc2ccc(cc2)C(F)(F)F)cc1OC1CCCC1 Show InChI InChI=1S/C29H32F3N5O3/c1-28(2,39-16-18-8-11-20(12-9-18)29(30,31)32)27-35-24-25(33)34-17-37(26(24)36-27)15-19-10-13-22(38-3)23(14-19)40-21-6-4-5-7-21/h8-14,17,21H,4-7,15-16,33H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar	PC cid PC sid UniChem Similars	Article PubMed	33	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Purdue Pharma LP					Assay Description PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...				J Med Chem 48: 1237-43 (2005) Article DOI: 10.1021/jm030603w BindingDB Entry DOI: 10.7270/Q2GT5KF0
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50285045 (1-isopropyl 3-methyl 4-(3-cyclopentyloxy-4-methoxy...) Show SMILES COC(=O)[C@@H]1CN(C[C@H]1c1ccc(OC)c(OC2CCCC2)c1)C(=O)OC(C)C Show InChI InChI=1S/C22H31NO6/c1-14(2)28-22(25)23-12-17(18(13-23)21(24)27-4)15-9-10-19(26-3)20(11-15)29-16-7-5-6-8-16/h9-11,14,16-18H,5-8,12-13H2,1-4H3/t17-,18+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article	40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Ability to inhibit the catalytic activity of human Phosphodiesterase 4B (PDE IVB)				Bioorg Med Chem Lett 5: 1977-1982 (1995) Article DOI: 10.1016/0960-894X(95)00336-R BindingDB Entry DOI: 10.7270/Q2PN95MX
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50314558 ((4-(3-(4-phenylpyridazino[4,5-b]indolizin-1-ylamin...) Show SMILES O=C(N1CCN(CCCNc2nnc(-c3ccccc3)c3c2cc2ccccn32)CC1)c1cnccn1 Show InChI InChI=1S/C28H28N8O/c37-28(24-20-29-11-12-30-24)35-17-15-34(16-18-35)13-6-10-31-27-23-19-22-9-4-5-14-36(22)26(23)25(32-33-27)21-7-2-1-3-8-21/h1-5,7-9,11-12,14,19-20H,6,10,13,15-18H2,(H,31,33)	PDB UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	41	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Displacement of [methyl-3H]rolipram from PDE4B3 expressed in CHO cells after 1 hr by scintillation counting				Bioorg Med Chem Lett 20: 2163-7 (2010) Article DOI: 10.1016/j.bmcl.2010.02.044 BindingDB Entry DOI: 10.7270/Q2NK3F54
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM14373 ((2E)-but-2-enedioic acid; 3-{[3-(cyclopentyloxy)-4...) Show SMILES COc1ccc(COC(C)(C)c2nc3c(N)ncn(Cc4ccc(OC)c(OC5CCCC5)c4)c3n2)cc1OC Show InChI InChI=1S/C30H37N5O5/c1-30(2,39-17-20-11-13-22(36-3)24(15-20)38-5)29-33-26-27(31)32-18-35(28(26)34-29)16-19-10-12-23(37-4)25(14-19)40-21-8-6-7-9-21/h10-15,18,21H,6-9,16-17,31H2,1-5H3	PDB UniProtKB/SwissProt GoogleScholar	PC cid PC sid UniChem Similars	Article PubMed	42.8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Purdue Pharma LP					Assay Description PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...				J Med Chem 48: 1237-43 (2005) Article DOI: 10.1021/jm030603w BindingDB Entry DOI: 10.7270/Q2GT5KF0
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM14385 (3-(3-Cyclopentyloxy-4-methoxy-benzyl)-8-[1,1-dimet...) Show SMILES COc1ccc(Cn2cnc(N)c3nc(nc23)C(C)(C)COc2cccs2)cc1OC1CCCC1 Show InChI InChI=1S/C26H31N5O3S/c1-26(2,15-33-21-9-6-12-35-21)25-29-22-23(27)28-16-31(24(22)30-25)14-17-10-11-19(32-3)20(13-17)34-18-7-4-5-8-18/h6,9-13,16,18H,4-5,7-8,14-15,27H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar	PC cid PC sid UniChem Similars	Article PubMed	46.9	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Purdue Pharma LP					Assay Description PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...				J Med Chem 48: 1237-43 (2005) Article DOI: 10.1021/jm030603w BindingDB Entry DOI: 10.7270/Q2GT5KF0
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50285042 (CHEMBL302632 | tert-butyl 3-(3-cyclopentyloxy-4-me...) Show SMILES COc1ccc(cc1OC1CCCC1)[C@@H]1CN(C[C@H]1CO)C(=O)OC(C)(C)C Show InChI InChI=1S/C22H33NO5/c1-22(2,3)28-21(25)23-12-16(14-24)18(13-23)15-9-10-19(26-4)20(11-15)27-17-7-5-6-8-17/h9-11,16-18,24H,5-8,12-14H2,1-4H3/t16-,18-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article	50	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Ability to inhibit the catalytic activity of human Phosphodiesterase 4B (PDE IVB)				Bioorg Med Chem Lett 5: 1977-1982 (1995) Article DOI: 10.1016/0960-894X(95)00336-R BindingDB Entry DOI: 10.7270/Q2PN95MX
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50285038 (1-benzyl 3-methyl 4-(3-cyclopentyloxy-4-methoxyphe...) Show SMILES COC(=O)[C@@H]1CN(C[C@H]1c1ccc(OC)c(OC2CCCC2)c1)C(=O)OCc1ccccc1 Show InChI InChI=1S/C26H31NO6/c1-30-23-13-12-19(14-24(23)33-20-10-6-7-11-20)21-15-27(16-22(21)25(28)31-2)26(29)32-17-18-8-4-3-5-9-18/h3-5,8-9,12-14,20-22H,6-7,10-11,15-17H2,1-2H3/t21-,22+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article	50	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Ability to inhibit the catalytic activity of human Phosphodiesterase 4B (PDE IVB)				Bioorg Med Chem Lett 5: 1977-1982 (1995) Article DOI: 10.1016/0960-894X(95)00336-R BindingDB Entry DOI: 10.7270/Q2PN95MX
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50285050 (CHEMBL59386 | methyl 3-(3-cyclopentyloxy-4-methoxy...) Show SMILES COC(=O)N1C[C@H]([C@@H](C1)[N+]([O-])=O)c1ccc(OC)c(OC2CCCC2)c1 Show InChI InChI=1S/C18H24N2O6/c1-24-16-8-7-12(9-17(16)26-13-5-3-4-6-13)14-10-19(18(21)25-2)11-15(14)20(22)23/h7-9,13-15H,3-6,10-11H2,1-2H3/t14-,15+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem	Article	60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Ability to inhibit the catalytic activity of human Phosphodiesterase 4B (PDE IVB)				Bioorg Med Chem Lett 5: 1977-1982 (1995) Article DOI: 10.1016/0960-894X(95)00336-R BindingDB Entry DOI: 10.7270/Q2PN95MX
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50029955 ((7R,7aR)-7-(3-Cyclopentyloxy-4-methoxy-phenyl)-hex...) Show SMILES COc1ccc(cc1OC1CCCC1)[C@H]1CCN2[C@@H]1CCC2=O Show InChI InChI=1S/C19H25NO3/c1-22-17-8-6-13(12-18(17)23-14-4-2-3-5-14)15-10-11-20-16(15)7-9-19(20)21/h6,8,12,14-16H,2-5,7,9-11H2,1H3/t15-,16-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	63	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Glaxo Wellcome Research Curated by ChEMBL					Assay Description Inhibition of human Phosphodiesterase 4B				J Med Chem 38: 4848-54 (1996) Article DOI: 10.1021/jm00024a012 BindingDB Entry DOI: 10.7270/Q2DZ079X
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50029951 ((7R,7aS)-7-(3-Cyclopentyloxy-4-methoxy-phenyl)-tet...) Show SMILES COc1ccc(cc1OC1CCCC1)[C@H]1CCN2[C@@H]1COC2=O Show InChI InChI=1S/C18H23NO4/c1-21-16-7-6-12(10-17(16)23-13-4-2-3-5-13)14-8-9-19-15(14)11-22-18(19)20/h6-7,10,13-15H,2-5,8-9,11H2,1H3/t14-,15-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Glaxo Wellcome Research Curated by ChEMBL					Assay Description Inhibition of human Phosphodiesterase 4B				J Med Chem 38: 4848-54 (1996) Article DOI: 10.1021/jm00024a012 BindingDB Entry DOI: 10.7270/Q2DZ079X
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM14377 (3-(3-Cyclopentyloxy-4-methoxy-benzyl)-8-[1-(4-cyan...) Show SMILES COc1ccc(Cn2cnc(N)c3nc(nc23)C(C)(C)OCc2ccc(cc2)C#N)cc1OC1CCCC1 Show InChI InChI=1S/C29H32N6O3/c1-29(2,37-17-20-10-8-19(15-30)9-11-20)28-33-25-26(31)32-18-35(27(25)34-28)16-21-12-13-23(36-3)24(14-21)38-22-6-4-5-7-22/h8-14,18,22H,4-7,16-17,31H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar	PC cid PC sid UniChem Similars	Article PubMed	71.3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Purdue Pharma LP					Assay Description PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...				J Med Chem 48: 1237-43 (2005) Article DOI: 10.1021/jm030603w BindingDB Entry DOI: 10.7270/Q2GT5KF0
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50314583 ((4-(3-(1,2-dimethyl-7-(3-nitrophenyl)-1H-pyrrolo[3...) Show SMILES Cc1cc2c(NCCCN3CCN(CC3)C(=O)c3cnccn3)nnc(-c3cccc(c3)[N+]([O-])=O)c2n1C Show InChI InChI=1S/C26H29N9O3/c1-18-15-21-24(32(18)2)23(19-5-3-6-20(16-19)35(37)38)30-31-25(21)29-7-4-10-33-11-13-34(14-12-33)26(36)22-17-27-8-9-28-22/h3,5-6,8-9,15-17H,4,7,10-14H2,1-2H3,(H,29,31)	PDB UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	77	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Displacement of [methyl-3H]rolipram from PDE4B3 expressed in CHO cells after 1 hr by scintillation counting				Bioorg Med Chem Lett 20: 2163-7 (2010) Article DOI: 10.1016/j.bmcl.2010.02.044 BindingDB Entry DOI: 10.7270/Q2NK3F54
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50285041 (CHEMBL301053 | methyl 3-cyano-4-(3-cyclopentyloxy-...) Show SMILES COC(=O)N1C[C@@H](C#N)[C@@H](C1)c1ccc(OC)c(OC2CCCC2)c1 Show InChI InChI=1S/C19H24N2O4/c1-23-17-8-7-13(9-18(17)25-15-5-3-4-6-15)16-12-21(19(22)24-2)11-14(16)10-20/h7-9,14-16H,3-6,11-12H2,1-2H3/t14-,16+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article	80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Ability to inhibit the catalytic activity of human Phosphodiesterase 4B (PDE IVB)				Bioorg Med Chem Lett 5: 1977-1982 (1995) Article DOI: 10.1016/0960-894X(95)00336-R BindingDB Entry DOI: 10.7270/Q2PN95MX
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50285057 (CHEMBL61876 | tert-butyl 3-(3-cyclopentyloxy-4-met...) Show SMILES COC[C@@H]1CN(C[C@H]1c1ccc(OC)c(OC2CCCC2)c1)C(=O)OC(C)(C)C Show InChI InChI=1S/C23H35NO5/c1-23(2,3)29-22(25)24-13-17(15-26-4)19(14-24)16-10-11-20(27-5)21(12-16)28-18-8-6-7-9-18/h10-12,17-19H,6-9,13-15H2,1-5H3/t17-,19-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article	80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Ability to inhibit the catalytic activity of human Phosphodiesterase 4B (PDE IVB)				Bioorg Med Chem Lett 5: 1977-1982 (1995) Article DOI: 10.1016/0960-894X(95)00336-R BindingDB Entry DOI: 10.7270/Q2PN95MX
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50285049 ((3S,4R)-4-(3-Cyclopentyloxy-4-methoxy-phenyl)-pyrr...) Show SMILES COc1ccc(cc1OC1CCCC1)[C@@H]1CN(C[C@H]1C(O)=O)C(=O)OC(C)(C)C Show InChI InChI=1S/C22H31NO6/c1-22(2,3)29-21(26)23-12-16(17(13-23)20(24)25)14-9-10-18(27-4)19(11-14)28-15-7-5-6-8-15/h9-11,15-17H,5-8,12-13H2,1-4H3,(H,24,25)/t16-,17+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article	150	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Ability to inhibit the catalytic activity of human Phosphodiesterase 4B (PDE IVB)				Bioorg Med Chem Lett 5: 1977-1982 (1995) Article DOI: 10.1016/0960-894X(95)00336-R BindingDB Entry DOI: 10.7270/Q2PN95MX
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50048243 ((3S,4R)-4-(3-Cyclopentyloxy-4-methoxy-phenyl)-pyrr...) Show SMILES COC(=O)[C@@H]1CN(C[C@H]1c1ccc(OC)c(OC2CCCC2)c1)C(=O)OC Show InChI InChI=1S/C20H27NO6/c1-24-17-9-8-13(10-18(17)27-14-6-4-5-7-14)15-11-21(20(23)26-3)12-16(15)19(22)25-2/h8-10,14-16H,4-7,11-12H2,1-3H3/t15-,16+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article	160	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Ability to inhibit the catalytic activity of human Phosphodiesterase 4B (PDE IVB)				Bioorg Med Chem Lett 5: 1977-1982 (1995) Article DOI: 10.1016/0960-894X(95)00336-R BindingDB Entry DOI: 10.7270/Q2PN95MX
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50285061 (CHEMBL61856 | tert-butyl 3-carbamoyl-4-(3-cyclopen...) Show SMILES COc1ccc(cc1OC1CCCC1)[C@@H]1CN(C[C@H]1C(N)=O)C(=O)OC(C)(C)C Show InChI InChI=1S/C22H32N2O5/c1-22(2,3)29-21(26)24-12-16(17(13-24)20(23)25)14-9-10-18(27-4)19(11-14)28-15-7-5-6-8-15/h9-11,15-17H,5-8,12-13H2,1-4H3,(H2,23,25)/t16-,17+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article	190	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Ability to inhibit the catalytic activity of human Phosphodiesterase 4B (PDE IVB)				Bioorg Med Chem Lett 5: 1977-1982 (1995) Article DOI: 10.1016/0960-894X(95)00336-R BindingDB Entry DOI: 10.7270/Q2PN95MX
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM30128 (phthalazinone, 21) Show SMILES COc1ccc(F)c(CCC2CCC(CCNCCCCCN3N=C(C4CC=CCC4C3=O)c3ccc(OC)c(OC)c3)O2)c1 Show InChI InChI=1S/C36H48FN3O5/c1-42-29-16-17-32(37)25(23-29)11-13-27-14-15-28(45-27)19-21-38-20-7-4-8-22-40-36(41)31-10-6-5-9-30(31)35(39-40)26-12-18-33(43-2)34(24-26)44-3/h5-6,12,16-18,23-24,27-28,30-31,38H,4,7-11,13-15,19-22H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar	PC cid PC sid UniChem Similars	Article PubMed	199	-39.4	n/a	n/a	n/a	n/a	n/a	8.0	34
Human BioMolecular Research Institute					Assay Description The samples were assayed in a solution composed of PDE4, [3H]cAMP/cAMP, and test compounds. To convert AMP to adenosine, snake venom was added to eac...				J Med Chem 52: 1530-9 (2009) Article DOI: 10.1021/jm8010993 BindingDB Entry DOI: 10.7270/Q2MK6B7M
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50314564 (4-(3-nitrophenyl)-N-(3-(4-(pyrimidin-2-yl)piperazi...) Show SMILES [O-][N+](=O)c1cccc(c1)-c1nnc(NCCCN2CCN(CC2)c2ncccn2)c2cc3ccccn3c12 Show InChI InChI=1S/C27H27N9O2/c37-36(38)22-8-3-6-20(18-22)24-25-23(19-21-7-1-2-13-35(21)25)26(32-31-24)28-11-5-12-33-14-16-34(17-15-33)27-29-9-4-10-30-27/h1-4,6-10,13,18-19H,5,11-12,14-17H2,(H,28,32)	PDB UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	210	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Displacement of [methyl-3H]rolipram from PDE4B3 expressed in CHO cells after 1 hr by scintillation counting				Bioorg Med Chem Lett 20: 2163-7 (2010) Article DOI: 10.1016/j.bmcl.2010.02.044 BindingDB Entry DOI: 10.7270/Q2NK3F54
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM14361 ((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...) Show SMILES COc1ccc(cc1OC1CCCC1)C1CNC(=O)C1 Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)	PDB UniProtKB/SwissProt GoogleScholar	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	PDB Article	220	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Ability to inhibit the catalytic activity of human Phosphodiesterase 4B (PDE IVB)				Bioorg Med Chem Lett 5: 1977-1982 (1995) Article DOI: 10.1016/0960-894X(95)00336-R BindingDB Entry DOI: 10.7270/Q2PN95MX
					More data for this Ligand-Target Pair				3D Structure (crystal)
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM14361 ((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...) Show SMILES COc1ccc(cc1OC1CCCC1)C1CNC(=O)C1 Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)	PDB UniProtKB/SwissProt GoogleScholar	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	221	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Glaxo Wellcome Research Curated by ChEMBL					Assay Description Inhibition of human Phosphodiesterase 4B				J Med Chem 38: 4848-54 (1996) Article DOI: 10.1021/jm00024a012 BindingDB Entry DOI: 10.7270/Q2DZ079X
					More data for this Ligand-Target Pair				3D Structure (crystal)
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50314581 ((4-(3-(1,2-dimethyl-7-(3-nitrophenyl)-1H-pyrrolo[3...) Show SMILES Cc1cc2c(NCCCN3CCN(CC3)C(=O)c3cncs3)nnc(-c3cccc(c3)[N+]([O-])=O)c2n1C Show InChI InChI=1S/C25H28N8O3S/c1-17-13-20-23(30(17)2)22(18-5-3-6-19(14-18)33(35)36)28-29-24(20)27-7-4-8-31-9-11-32(12-10-31)25(34)21-15-26-16-37-21/h3,5-6,13-16H,4,7-12H2,1-2H3,(H,27,29)	PDB UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	222	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Displacement of [methyl-3H]rolipram from PDE4B3 expressed in CHO cells after 1 hr by scintillation counting				Bioorg Med Chem Lett 20: 2163-7 (2010) Article DOI: 10.1016/j.bmcl.2010.02.044 BindingDB Entry DOI: 10.7270/Q2NK3F54
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50314578 ((4-(3-(1,2-dimethyl-7-(3-nitrophenyl)-1H-pyrrolo[3...) Show SMILES Cc1cc2c(NCCCN3CCN(CC3)C(=O)c3ccccn3)nnc(-c3cccc(c3)[N+]([O-])=O)c2n1C Show InChI InChI=1S/C27H30N8O3/c1-19-17-22-25(32(19)2)24(20-7-5-8-21(18-20)35(37)38)30-31-26(22)29-11-6-12-33-13-15-34(16-14-33)27(36)23-9-3-4-10-28-23/h3-5,7-10,17-18H,6,11-16H2,1-2H3,(H,29,31)	PDB UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	238	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Displacement of [methyl-3H]rolipram from PDE4B3 expressed in CHO cells after 1 hr by scintillation counting				Bioorg Med Chem Lett 20: 2163-7 (2010) Article DOI: 10.1016/j.bmcl.2010.02.044 BindingDB Entry DOI: 10.7270/Q2NK3F54
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50285054 (1-(tert-butyl) 3-methyl 4-[4-methoxy-3-(3-phenoxyp...) Show SMILES COC(=O)[C@@H]1CN(C[C@H]1c1ccc(OC)c(OCCCOc2ccccc2)c1)C(=O)OC(C)(C)C Show InChI InChI=1S/C27H35NO7/c1-27(2,3)35-26(30)28-17-21(22(18-28)25(29)32-5)19-12-13-23(31-4)24(16-19)34-15-9-14-33-20-10-7-6-8-11-20/h6-8,10-13,16,21-22H,9,14-15,17-18H2,1-5H3/t21-,22+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article	240	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Ability to inhibit the catalytic activity of human Phosphodiesterase 4B (PDE IVB)				Bioorg Med Chem Lett 5: 1977-1982 (1995) Article DOI: 10.1016/0960-894X(95)00336-R BindingDB Entry DOI: 10.7270/Q2PN95MX
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50314571 ((4-(3-(4-(3-fluorophenyl)pyridazino[4,5-b]indolizi...) Show SMILES Fc1cccc(c1)-c1nnc(NCCCN2CCN(CC2)C(=O)c2ccccn2)c2cc3ccccn3c12 Show InChI InChI=1S/C29H28FN7O/c30-22-8-5-7-21(19-22)26-27-24(20-23-9-2-4-14-37(23)27)28(34-33-26)32-12-6-13-35-15-17-36(18-16-35)29(38)25-10-1-3-11-31-25/h1-5,7-11,14,19-20H,6,12-13,15-18H2,(H,32,34)	PDB UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	241	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Displacement of [methyl-3H]rolipram from PDE4B3 expressed in CHO cells after 1 hr by scintillation counting				Bioorg Med Chem Lett 20: 2163-7 (2010) Article DOI: 10.1016/j.bmcl.2010.02.044 BindingDB Entry DOI: 10.7270/Q2NK3F54
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM30126 (CHEMBL313041 | phthalazinone, 19) Show SMILES COc1ccc(cc1OC)C1=NNC(=O)C2CC=CCC12 Show InChI InChI=1S/C16H18N2O3/c1-20-13-8-7-10(9-14(13)21-2)15-11-5-3-4-6-12(11)16(19)18-17-15/h3-4,7-9,11-12H,5-6H2,1-2H3,(H,18,19)	PDB UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	250	-38.8	n/a	n/a	n/a	n/a	n/a	8.0	34
Human BioMolecular Research Institute					Assay Description The samples were assayed in a solution composed of PDE4, [3H]cAMP/cAMP, and test compounds. To convert AMP to adenosine, snake venom was added to eac...				J Med Chem 52: 1530-9 (2009) Article DOI: 10.1021/jm8010993 BindingDB Entry DOI: 10.7270/Q2MK6B7M
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM14389 (3-(3-Cyclopentyloxy-4-methoxy-benzyl)-8-[1-(4-fluo...) Show SMILES COc1ccc(Cn2cnc(N)c3nc(nc23)C(C)OCc2ccc(F)cc2)cc1OC1CCCC1 Show InChI InChI=1S/C27H30FN5O3/c1-17(35-15-18-7-10-20(28)11-8-18)26-31-24-25(29)30-16-33(27(24)32-26)14-19-9-12-22(34-2)23(13-19)36-21-5-3-4-6-21/h7-13,16-17,21H,3-6,14-15,29H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar	PC cid PC sid UniChem Similars	Article PubMed	269	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Purdue Pharma LP					Assay Description PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...				J Med Chem 48: 1237-43 (2005) Article DOI: 10.1021/jm030603w BindingDB Entry DOI: 10.7270/Q2GT5KF0
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM14364 (3-(3-Cyclopentyloxy-4-methoxy-benzyl)-8-isopropyl-...) Show SMILES CCNc1ncn(Cc2ccc(OC)c(OC3CCCC3)c2)c2nc(nc12)C(C)C Show InChI InChI=1S/C23H31N5O2/c1-5-24-22-20-23(27-21(26-20)15(2)3)28(14-25-22)13-16-10-11-18(29-4)19(12-16)30-17-8-6-7-9-17/h10-12,14-15,17,24H,5-9,13H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar	PC cid PC sid UniChem Patents Similars	Article PubMed	270	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Purdue Pharma LP					Assay Description PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...				J Med Chem 48: 1237-43 (2005) Article DOI: 10.1021/jm030603w BindingDB Entry DOI: 10.7270/Q2GT5KF0
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50029953 ((7R,7aR)-7-(3-Cyclopentyloxy-4-methoxy-phenyl)-tet...) Show SMILES COc1ccc(cc1OC1CCCC1)[C@H]1CCN2[C@H]1COC2=O Show InChI InChI=1S/C18H23NO4/c1-21-16-7-6-12(10-17(16)23-13-4-2-3-5-13)14-8-9-19-15(14)11-22-18(19)20/h6-7,10,13-15H,2-5,8-9,11H2,1H3/t14-,15+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	282	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Glaxo Wellcome Research Curated by ChEMBL					Assay Description Inhibition of human Phosphodiesterase 4B				J Med Chem 38: 4848-54 (1996) Article DOI: 10.1021/jm00024a012 BindingDB Entry DOI: 10.7270/Q2DZ079X
					More data for this Ligand-Target Pair

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