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Compile Data Set for Download or QSAR

Found 1004 hits Enz. Inhib. hit(s) with Target = 'cGMP-dependent 3',5'-cyclic phosphodiesterase'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50028191
PNG
((R)-7-(2-hydroxypropyl)-1,3-dimethyl-1H-purine-2,6...)
Show SMILES C[C@@H](O)Cn1cnc2n(C)c(=O)n(C)c(=O)c12
Show InChI InChI=1S/C10H14N4O3/c1-6(15)4-14-5-11-8-7(14)9(16)13(3)10(17)12(8)2/h5-6,15H,4H2,1-3H3/t6-/m1/s1
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0.600n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of human lung low-affinity cGMP phosphodiesterases (10-50 microM/L)


J Med Chem 26: 1514-8 (1983)


Article DOI: 10.1021/jm00364a029
BindingDB Entry DOI: 10.7270/Q21Z43F5
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50028190
PNG
(7-(2-Hydroxy-propyl)-1,3-dimethyl-3,7-dihydro-puri...)
Show SMILES CC(O)Cn1cnc2n(C)c(=O)n(C)c(=O)c12
Show InChI InChI=1S/C10H14N4O3/c1-6(15)4-14-5-11-8-7(14)9(16)13(3)10(17)12(8)2/h5-6,15H,4H2,1-3H3
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0.600n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of human lung low-affinity cGMP phosphodiesterases (10-50 microM/L)


J Med Chem 26: 1514-8 (1983)


Article DOI: 10.1021/jm00364a029
BindingDB Entry DOI: 10.7270/Q21Z43F5
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50028192
PNG
((S)-7-(2-hydroxypropyl)-1,3-dimethyl-1H-purine-2,6...)
Show SMILES C[C@H](O)Cn1cnc2n(C)c(=O)n(C)c(=O)c12
Show InChI InChI=1S/C10H14N4O3/c1-6(15)4-14-5-11-8-7(14)9(16)13(3)10(17)12(8)2/h5-6,15H,4H2,1-3H3/t6-/m0/s1
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0.700n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of human lung low-affinity cGMP phosphodiesterases (10-50 microM/L)


J Med Chem 26: 1514-8 (1983)


Article DOI: 10.1021/jm00364a029
BindingDB Entry DOI: 10.7270/Q21Z43F5
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50444037
PNG
(CHEMBL3092564 | US8680116, 1-15)
Show SMILES O=c1[nH]c2ccc(cc2c(OCC2CCNCC2)c1-c1cccs1)C#Cc1cccnc1
Show InChI InChI=1S/C26H23N3O2S/c30-26-24(23-4-2-14-32-23)25(31-17-20-9-12-27-13-10-20)21-15-18(7-8-22(21)29-26)5-6-19-3-1-11-28-16-19/h1-4,7-8,11,14-16,20,27H,9-10,12-13,17H2,(H,29,30)
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1.30n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US8680116 (2014)


BindingDB Entry DOI: 10.7270/Q2N29VM1
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM119685
PNG
(US8680116, 1-57)
Show SMILES CC(C)(O)C#Cc1ccc2[nH]c(=O)c(-c3cccs3)c(OCC3CCOCC3)c2c1
Show InChI InChI=1S/C24H25NO4S/c1-24(2,27)10-7-16-5-6-19-18(14-16)22(29-15-17-8-11-28-12-9-17)21(23(26)25-19)20-4-3-13-30-20/h3-6,13-14,17,27H,8-9,11-12,15H2,1-2H3,(H,25,26)
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1.80n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US8680116 (2014)


BindingDB Entry DOI: 10.7270/Q2N29VM1
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM119686
PNG
(US8680116, 1-63)
Show SMILES COc1cc2[nH]c(=O)c(-c3cccs3)c(-c3cccc(c3)-c3ccccn3)c2cc1OC
Show InChI InChI=1S/C26H20N2O3S/c1-30-21-14-18-20(15-22(21)31-2)28-26(29)25(23-10-6-12-32-23)24(18)17-8-5-7-16(13-17)19-9-3-4-11-27-19/h3-15H,1-2H3,(H,28,29)
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34n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US8680116 (2014)


BindingDB Entry DOI: 10.7270/Q2N29VM1
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM119682
PNG
(US8680116, 1-23)
Show SMILES CN1CCC(COc2c(-c3cccs3)c(=O)[nH]c3ccc(cc23)C#Cc2cccnc2)CC1
Show InChI InChI=1S/C27H25N3O2S/c1-30-13-10-21(11-14-30)18-32-26-22-16-19(6-7-20-4-2-12-28-17-20)8-9-23(22)29-27(31)25(26)24-5-3-15-33-24/h2-5,8-9,12,15-17,21H,10-11,13-14,18H2,1H3,(H,29,31)
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62n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US8680116 (2014)


BindingDB Entry DOI: 10.7270/Q2N29VM1
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM119680
PNG
(US8680116, 1-13)
Show SMILES CN1CCC(COc2c(-c3cccs3)c(=O)[nH]c3ccc(Br)cc23)CC1
Show InChI InChI=1S/C20H21BrN2O2S/c1-23-8-6-13(7-9-23)12-25-19-15-11-14(21)4-5-16(15)22-20(24)18(19)17-3-2-10-26-17/h2-5,10-11,13H,6-9,12H2,1H3,(H,22,24)
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73n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US8680116 (2014)


BindingDB Entry DOI: 10.7270/Q2N29VM1
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM119687
PNG
(US8680116, 1-85)
Show SMILES COc1cc2[nH]c(=O)c(-c3cccs3)c(-c3cccc(c3)C3CCCC3)c2cc1OC
Show InChI InChI=1S/C26H25NO3S/c1-29-21-14-19-20(15-22(21)30-2)27-26(28)25(23-11-6-12-31-23)24(19)18-10-5-9-17(13-18)16-7-3-4-8-16/h5-6,9-16H,3-4,7-8H2,1-2H3,(H,27,28)
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110n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US8680116 (2014)


BindingDB Entry DOI: 10.7270/Q2N29VM1
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM119683
PNG
(US8680116, 1-48)
Show SMILES O=c1[nH]c2ccc(cc2c(OCc2ccccn2)c1-c1cccs1)-c1ccncc1
Show InChI InChI=1S/C24H17N3O2S/c28-24-22(21-5-3-13-30-21)23(29-15-18-4-1-2-10-26-18)19-14-17(6-7-20(19)27-24)16-8-11-25-12-9-16/h1-14H,15H2,(H,27,28)
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160n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US8680116 (2014)


BindingDB Entry DOI: 10.7270/Q2N29VM1
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM119681
PNG
(US8680116, 1-18)
Show SMILES COc1cc2[nH]c(=O)c(-c3cccs3)c(-c3cccc(c3)C#N)c2cc1-c1ccccc1
Show InChI InChI=1S/C27H18N2O2S/c1-31-23-15-22-21(14-20(23)18-8-3-2-4-9-18)25(19-10-5-7-17(13-19)16-28)26(27(30)29-22)24-11-6-12-32-24/h2-15H,1H3,(H,29,30)
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200n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US8680116 (2014)


BindingDB Entry DOI: 10.7270/Q2N29VM1
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM119684
PNG
(US8680116, 1-51)
Show SMILES Brc1ccc2[nH]c(=O)c(-c3cccs3)c(\C=C\c3ccccn3)c2c1
Show InChI InChI=1S/C20H13BrN2OS/c21-13-6-9-17-16(12-13)15(8-7-14-4-1-2-10-22-14)19(20(24)23-17)18-5-3-11-25-18/h1-12H,(H,23,24)/b8-7+
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900n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US8680116 (2014)


BindingDB Entry DOI: 10.7270/Q2N29VM1
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50034908
PNG
((2R,3S)-3-((R)-6-Amino-purin-9-yl)-nonan-2-ol | (2...)
Show SMILES CCCCCC[C@@H]([C@@H](C)O)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C14H23N5O/c1-3-4-5-6-7-11(10(2)20)19-9-18-12-13(15)16-8-17-14(12)19/h8-11,20H,3-7H2,1-2H3,(H2,15,16,17)/t10-,11+/m1/s1
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1.00E+3n/an/an/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of human phosphodiesterase 2


J Med Chem 48: 3449-62 (2005)


Article DOI: 10.1021/jm040217u
BindingDB Entry DOI: 10.7270/Q21G0N2H
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50034908
PNG
((2R,3S)-3-((R)-6-Amino-purin-9-yl)-nonan-2-ol | (2...)
Show SMILES CCCCCC[C@@H]([C@@H](C)O)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C14H23N5O/c1-3-4-5-6-7-11(10(2)20)19-9-18-12-13(15)16-8-17-14(12)19/h8-11,20H,3-7H2,1-2H3,(H2,15,16,17)/t10-,11+/m1/s1
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2.80E+3n/an/an/an/an/an/an/an/a



UPR 421 du CNRS

Curated by ChEMBL


Assay Description
Inhibition of Phosphodiesterase 2


J Med Chem 40: 1768-70 (1997)


Article DOI: 10.1021/jm960827x
BindingDB Entry DOI: 10.7270/Q25T3M4T
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50362048
PNG
(CHEMBL1940058)
Show SMILES CC(C)Oc1cc(C)c2nc3[nH]nc(C)c3c(CN3CCCOCC3)c2c1
Show InChI InChI=1S/C21H28N4O2/c1-13(2)27-16-10-14(3)20-17(11-16)18(12-25-6-5-8-26-9-7-25)19-15(4)23-24-21(19)22-20/h10-11,13H,5-9,12H2,1-4H3,(H,22,23,24)
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>1.00E+4n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]cAMP from PDE2A by competitive binding assay


Bioorg Med Chem Lett 22: 235-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.023
BindingDB Entry DOI: 10.7270/Q2862GWC
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50362047
PNG
(CHEMBL1940057)
Show SMILES COCCOc1cc(C)c2nc3[nH]nc(C)c3c(CN3CCCOCC3)c2c1
Show InChI InChI=1S/C21H28N4O3/c1-14-11-16(28-10-9-26-3)12-17-18(13-25-5-4-7-27-8-6-25)19-15(2)23-24-21(19)22-20(14)17/h11-12H,4-10,13H2,1-3H3,(H,22,23,24)
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>1.00E+4n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]cAMP from PDE2A by competitive binding assay


Bioorg Med Chem Lett 22: 235-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.023
BindingDB Entry DOI: 10.7270/Q2862GWC
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50362046
PNG
(CHEMBL1940056)
Show SMILES Cc1n[nH]c2nc3c(C)cc(O)cc3c(CN3CCCOCC3)c12
Show InChI InChI=1S/C18H22N4O2/c1-11-8-13(23)9-14-15(10-22-4-3-6-24-7-5-22)16-12(2)20-21-18(16)19-17(11)14/h8-9,23H,3-7,10H2,1-2H3,(H,19,20,21)
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>1.00E+4n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]cAMP from PDE2A by competitive binding assay


Bioorg Med Chem Lett 22: 235-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.023
BindingDB Entry DOI: 10.7270/Q2862GWC
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50362043
PNG
(CHEMBL1940053)
Show SMILES COc1cc(C)c2nc3[nH]nc(C)c3c(CN3CCCOCC3)c2c1
Show InChI InChI=1S/C19H24N4O2/c1-12-9-14(24-3)10-15-16(11-23-5-4-7-25-8-6-23)17-13(2)21-22-19(17)20-18(12)15/h9-10H,4-8,11H2,1-3H3,(H,20,21,22)
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>1.00E+4n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]cAMP from PDE2A by competitive binding assay


Bioorg Med Chem Lett 22: 235-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.023
BindingDB Entry DOI: 10.7270/Q2862GWC
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50362033
PNG
(CHEMBL1939912)
Show SMILES COc1cc(C)c2nc3[nH]nc(C)c3c(CN3CC[C@@H](O)C3)c2c1
Show InChI InChI=1S/C18H22N4O2/c1-10-6-13(24-3)7-14-15(9-22-5-4-12(23)8-22)16-11(2)20-21-18(16)19-17(10)14/h6-7,12,23H,4-5,8-9H2,1-3H3,(H,19,20,21)/t12-/m1/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]cAMP from PDE2A by competitive binding assay


Bioorg Med Chem Lett 22: 235-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.023
BindingDB Entry DOI: 10.7270/Q2862GWC
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50362035
PNG
(CHEMBL1939914)
Show SMILES COc1cc(C)c2nc3[nH]nc(C)c3c(CN3CCOCC3)c2c1
Show InChI InChI=1S/C18H22N4O2/c1-11-8-13(23-3)9-14-15(10-22-4-6-24-7-5-22)16-12(2)20-21-18(16)19-17(11)14/h8-9H,4-7,10H2,1-3H3,(H,19,20,21)
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>1.00E+4n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]cAMP from PDE2A by competitive binding assay


Bioorg Med Chem Lett 22: 235-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.023
BindingDB Entry DOI: 10.7270/Q2862GWC
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50362036
PNG
(CHEMBL1939915)
Show SMILES COc1cc(C)c2nc3[nH]nc(C)c3c(CN3CCOC(C)C3)c2c1
Show InChI InChI=1S/C19H24N4O2/c1-11-7-14(24-4)8-15-16(10-23-5-6-25-12(2)9-23)17-13(3)21-22-19(17)20-18(11)15/h7-8,12H,5-6,9-10H2,1-4H3,(H,20,21,22)
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>1.00E+4n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]cAMP from PDE2A by competitive binding assay


Bioorg Med Chem Lett 22: 235-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.023
BindingDB Entry DOI: 10.7270/Q2862GWC
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50150119
PNG
(CHEMBL3769414)
Show SMILES CN1C2=N[C@@H]3CCC[C@@H]3N2c2nn(Cc3ccc(cc3)-c3cccc(F)n3)c(Nc3ccccc3)c2C1=O
Show InChI InChI=1S/C29H26FN7O/c1-35-28(38)25-26(31-20-7-3-2-4-8-20)36(34-27(25)37-23-11-5-10-22(23)33-29(35)37)17-18-13-15-19(16-14-18)21-9-6-12-24(30)32-21/h2-4,6-9,12-16,22-23,31H,5,10-11,17H2,1H3/t22-,23+/m1/s1
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1.80E+4n/an/an/an/an/an/an/an/a



Intra-Cellular Therapies, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant full length human PDE2A using fluorescent labeled cAMP as substrate after 15 mins by IMAP assay


J Med Chem 59: 1149-64 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01751
BindingDB Entry DOI: 10.7270/Q2X068W7
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50150264
PNG
(CHEMBL3769817)
Show SMILES CN1C2=N[C@@H]3CCC[C@@H]3N2c2nn(Cc3ccc(cc3)-c3ccccn3)c(Nc3ccccc3)c2C1=O
Show InChI InChI=1S/C29H27N7O/c1-34-28(37)25-26(31-21-8-3-2-4-9-21)35(33-27(25)36-24-12-7-11-23(24)32-29(34)36)18-19-13-15-20(16-14-19)22-10-5-6-17-30-22/h2-6,8-10,13-17,23-24,31H,7,11-12,18H2,1H3/t23-,24+/m1/s1
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2.40E+4n/an/an/an/an/an/an/an/a



Intra-Cellular Therapies, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant full length human PDE2A using fluorescent labeled cAMP as substrate after 15 mins by IMAP assay


J Med Chem 59: 1149-64 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01751
BindingDB Entry DOI: 10.7270/Q2X068W7
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50150171
PNG
(CHEMBL3770470)
Show SMILES CN1C2=N[C@@H]3CCC[C@@H]3N2c2nn(Cc3ccc(cc3)-c3ccccc3)c(Nc3ccccc3)c2C1=O
Show InChI InChI=1S/C30H28N6O/c1-34-29(37)26-27(31-23-11-6-3-7-12-23)35(33-28(26)36-25-14-8-13-24(25)32-30(34)36)19-20-15-17-22(18-16-20)21-9-4-2-5-10-21/h2-7,9-12,15-18,24-25,31H,8,13-14,19H2,1H3/t24-,25+/m1/s1
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3.70E+4n/an/an/an/an/an/an/an/a



Intra-Cellular Therapies, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant full length human PDE2A using fluorescent labeled cAMP as substrate after 15 mins by IMAP assay


J Med Chem 59: 1149-64 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01751
BindingDB Entry DOI: 10.7270/Q2X068W7
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50150239
PNG
(CHEMBL3769461)
Show SMILES CN1C2=N[C@@H]3CCC[C@@H]3N2c2nn(Cc3ccc(cc3)C(F)(F)F)c(Nc3ccccc3)c2C1=O
Show InChI InChI=1S/C25H23F3N6O/c1-32-23(35)20-21(29-17-6-3-2-4-7-17)33(14-15-10-12-16(13-11-15)25(26,27)28)31-22(20)34-19-9-5-8-18(19)30-24(32)34/h2-4,6-7,10-13,18-19,29H,5,8-9,14H2,1H3/t18-,19+/m1/s1
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3.90E+4n/an/an/an/an/an/an/an/a



Intra-Cellular Therapies, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant full length human PDE2A using fluorescent labeled cAMP as substrate after 15 mins by IMAP assay


J Med Chem 59: 1149-64 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01751
BindingDB Entry DOI: 10.7270/Q2X068W7
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50150238
PNG
(CHEMBL3770107)
Show SMILES CN1C2=N[C@@H]3CCC[C@@H]3N2c2nn(Cc3ccc(nc3)C(F)(F)F)c(Nc3ccccc3)c2C1=O
Show InChI InChI=1S/C24H22F3N7O/c1-32-22(35)19-20(29-15-6-3-2-4-7-15)33(13-14-10-11-18(28-12-14)24(25,26)27)31-21(19)34-17-9-5-8-16(17)30-23(32)34/h2-4,6-7,10-12,16-17,29H,5,8-9,13H2,1H3/t16-,17+/m1/s1
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>1.00E+5n/an/an/an/an/an/an/an/a



Intra-Cellular Therapies, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant full length human PDE2A using fluorescent labeled cAMP as substrate after 15 mins by IMAP assay


J Med Chem 59: 1149-64 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01751
BindingDB Entry DOI: 10.7270/Q2X068W7
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50058210
PNG
(CHEMBL445098 | [9-(2-Fluoro-benzyl)-9H-purin-6-yl]...)
Show SMILES CNc1ncnc2n(Cc3ccccc3F)cnc12
Show InChI InChI=1S/C13H12FN5/c1-15-12-11-13(17-7-16-12)19(8-18-11)6-9-4-2-3-5-10(9)14/h2-5,7-8H,6H2,1H3,(H,15,16,17)
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1.22E+5n/an/an/an/an/an/an/an/a



UPR 421 du CNRS

Curated by ChEMBL


Assay Description
Inhibition of Phosphodiesterase 2


J Med Chem 40: 1768-70 (1997)


Article DOI: 10.1021/jm960827x
BindingDB Entry DOI: 10.7270/Q25T3M4T
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM14361
PNG
((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Show SMILES COc1ccc(cc1OC1CCCC1)C1CNC(=O)C1
Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)
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>2.00E+5n/an/an/an/an/an/an/an/a



UPR 421 du CNRS

Curated by ChEMBL


Assay Description
Inhibition of Phosphodiesterase 2


J Med Chem 40: 1768-70 (1997)


Article DOI: 10.1021/jm960827x
BindingDB Entry DOI: 10.7270/Q25T3M4T
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM171943
PNG
(US9085584, 113)
Show SMILES Cc1nc2ccc(nc2n2c(nnc12)-c1cc(ccc1Cl)C1(O)CCCOC1)C1CC1
Show InChI InChI=1S/C23H22ClN5O2/c1-13-20-27-28-21(29(20)22-19(25-13)8-7-18(26-22)14-3-4-14)16-11-15(5-6-17(16)24)23(30)9-2-10-31-12-23/h5-8,11,14,30H,2-4,9-10,12H2,1H3
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n/an/a 0.200n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of PDE 2A or 10 enzyme activity was assessed using IMAP-Phosphodiesterase-cAMP fluorescence labeled substrate (Molecular Devices, Orde...


US Patent US9085584 (2015)


BindingDB Entry DOI: 10.7270/Q27P8X54
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50425140
PNG
(CHEMBL2313250)
Show SMILES CCNC(=O)c1ccc2nc(C)c3nnc(-c4c(Cl)cccc4Cl)n3c2c1
Show InChI InChI=1S/C19H15Cl2N5O/c1-3-22-19(27)11-7-8-14-15(9-11)26-17(10(2)23-14)24-25-18(26)16-12(20)5-4-6-13(16)21/h4-9H,3H2,1-2H3,(H,22,27)
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n/an/a 0.280n/an/an/an/an/an/a



Janssen-Cilag S.A.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE2A expressed in Sf9 cells by scintillation proximity assay


Bioorg Med Chem Lett 23: 785-90 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.077
BindingDB Entry DOI: 10.7270/Q2C82BMR
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM107776
PNG
(US8598155, 13)
Show SMILES Cc1nc(-c2cnn(C)c2-c2ccc(cc2)C(F)(F)F)c2c(ncnn12)N1CCC1
Show InChI InChI=1S/C20H18F3N7/c1-12-27-16(18-19(29-8-3-9-29)24-11-26-30(12)18)15-10-25-28(2)17(15)13-4-6-14(7-5-13)20(21,22)23/h4-7,10-11H,3,8-9H2,1-2H3
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n/an/a 0.303n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximity assay (SPA) modifie...


US Patent US8598155 (2013)


BindingDB Entry DOI: 10.7270/Q26T0K8C
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50425132
PNG
(CHEMBL2313258)
Show SMILES Cc1nc2ccc(cc2n2c(nnc12)-c1ccccc1Cl)C(=O)NCc1ccccc1
Show InChI InChI=1S/C24H18ClN5O/c1-15-22-28-29-23(18-9-5-6-10-19(18)25)30(22)21-13-17(11-12-20(21)27-15)24(31)26-14-16-7-3-2-4-8-16/h2-13H,14H2,1H3,(H,26,31)
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n/an/a 0.380n/an/an/an/an/an/a



Janssen-Cilag S.A.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE2A expressed in Sf9 cells by scintillation proximity assay


Bioorg Med Chem Lett 23: 785-90 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.077
BindingDB Entry DOI: 10.7270/Q2C82BMR
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50425126
PNG
(CHEMBL2313231)
Show SMILES Cc1nc2ccc(cc2n2c(nnc12)-c1ccccc1Cl)C(=O)NCc1ccccn1
Show InChI InChI=1S/C23H17ClN6O/c1-14-21-28-29-22(17-7-2-3-8-18(17)24)30(21)20-12-15(9-10-19(20)27-14)23(31)26-13-16-6-4-5-11-25-16/h2-12H,13H2,1H3,(H,26,31)
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n/an/a 0.420n/an/an/an/an/an/a



Janssen-Cilag S.A.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE2A expressed in Sf9 cells by scintillation proximity assay


Bioorg Med Chem Lett 23: 785-90 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.077
BindingDB Entry DOI: 10.7270/Q2C82BMR
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50425127
PNG
(CHEMBL2313263)
Show SMILES Cc1nc2ccc(cc2n2c(nnc12)-c1ccccc1Cl)C(=O)NCCN1CCOCC1
Show InChI InChI=1S/C23H23ClN6O2/c1-15-21-27-28-22(17-4-2-3-5-18(17)24)30(21)20-14-16(6-7-19(20)26-15)23(31)25-8-9-29-10-12-32-13-11-29/h2-7,14H,8-13H2,1H3,(H,25,31)
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n/an/a 0.470n/an/an/an/an/an/a



Janssen-Cilag S.A.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE2A expressed in Sf9 cells by scintillation proximity assay


Bioorg Med Chem Lett 23: 785-90 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.077
BindingDB Entry DOI: 10.7270/Q2C82BMR
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM107778
PNG
(US8598155, 15)
Show SMILES CCc1ccc(cc1)-c1c(cnn1C)-c1nc(C)n2ncnc(N3CCC3)c12
Show InChI InChI=1S/C21H23N7/c1-4-15-6-8-16(9-7-15)19-17(12-23-26(19)3)18-20-21(27-10-5-11-27)22-13-24-28(20)14(2)25-18/h6-9,12-13H,4-5,10-11H2,1-3H3
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n/an/a 0.517n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximity assay (SPA) modifie...


US Patent US8598155 (2013)


BindingDB Entry DOI: 10.7270/Q26T0K8C
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM107849
PNG
(US8598155, 8)
Show SMILES COc1ccc(-c2c(cnn2C)-c2nc(C)n3ncnc(N4CCC4)c23)c(C)c1
Show InChI InChI=1S/C21H23N7O/c1-13-10-15(29-4)6-7-16(13)19-17(11-23-26(19)3)18-20-21(27-8-5-9-27)22-12-24-28(20)14(2)25-18/h6-7,10-12H,5,8-9H2,1-4H3
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n/an/a 0.578n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximity assay (SPA) modifie...


US Patent US8598155 (2013)


BindingDB Entry DOI: 10.7270/Q26T0K8C
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50425143
PNG
(CHEMBL2313247)
Show SMILES CCNC(=O)c1ccc2nc(C)c3nnc(-c4ccccc4Cl)n3c2c1
Show InChI InChI=1S/C19H16ClN5O/c1-3-21-19(26)12-8-9-15-16(10-12)25-17(11(2)22-15)23-24-18(25)13-6-4-5-7-14(13)20/h4-10H,3H2,1-2H3,(H,21,26)
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n/an/a 0.600n/an/an/an/an/an/a



Janssen-Cilag S.A.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE2A expressed in Sf9 cells by scintillation proximity assay


Bioorg Med Chem Lett 23: 785-90 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.077
BindingDB Entry DOI: 10.7270/Q2C82BMR
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50434022
PNG
(CHEMBL2381188 | US8598155, 52)
Show SMILES Cc1nc(-c2cnn(C)c2-c2ccc(cc2)C(F)(F)F)c2c(ncnn12)N1CC(F)C1
Show InChI InChI=1S/C20H17F4N7/c1-11-28-16(18-19(25-10-27-31(11)18)30-8-14(21)9-30)15-7-26-29(2)17(15)12-3-5-13(6-4-12)20(22,23)24/h3-7,10,14H,8-9H2,1-2H3
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n/an/a 0.633n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximity assay (SPA) modifie...


US Patent US8598155 (2013)


BindingDB Entry DOI: 10.7270/Q26T0K8C
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM107819
PNG
(US8598155, 57)
Show SMILES COc1ccc(-c2c(cnn2C)-c2nc(C)n3ncnc(N4CCC4)c23)c(Cl)c1
Show InChI InChI=1S/C20H20ClN7O/c1-12-25-17(19-20(27-7-4-8-27)22-11-24-28(12)19)15-10-23-26(2)18(15)14-6-5-13(29-3)9-16(14)21/h5-6,9-11H,4,7-8H2,1-3H3
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n/an/a 0.761n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximity assay (SPA) modifie...


US Patent US8598155 (2013)


BindingDB Entry DOI: 10.7270/Q26T0K8C
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM107773
PNG
(US8598155, 9)
Show SMILES CNc1ncnn2c(CO)nc(-c3cnn(C)c3-c3ccc(cc3)C(F)(F)F)c12
Show InChI InChI=1S/C18H16F3N7O/c1-22-17-16-14(26-13(8-29)28(16)25-9-23-17)12-7-24-27(2)15(12)10-3-5-11(6-4-10)18(19,20)21/h3-7,9,29H,8H2,1-2H3,(H,22,23,25)
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Pfizer Inc.

US Patent


Assay Description
The activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximity assay (SPA) modifie...


US Patent US8598155 (2013)


BindingDB Entry DOI: 10.7270/Q26T0K8C
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM107799
PNG
(US8598155, 36)
Show SMILES COc1ccc(-c2c(cnn2C)-c2nc(C)n3ncnc(N4CCC4)c23)c(F)c1
Show InChI InChI=1S/C20H20FN7O/c1-12-25-17(19-20(27-7-4-8-27)22-11-24-28(12)19)15-10-23-26(2)18(15)14-6-5-13(29-3)9-16(14)21/h5-6,9-11H,4,7-8H2,1-3H3
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Pfizer Inc.

US Patent


Assay Description
The activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximity assay (SPA) modifie...


US Patent US8598155 (2013)


BindingDB Entry DOI: 10.7270/Q26T0K8C
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM107814
PNG
(US8598155, 51)
Show SMILES Cc1nc(-c2cnn(C)c2-c2ccc(cc2C#N)C(F)(F)F)c2c(ncnn12)N1CCC1
Show InChI InChI=1S/C21H17F3N8/c1-12-29-17(19-20(31-6-3-7-31)26-11-28-32(12)19)16-10-27-30(2)18(16)15-5-4-14(21(22,23)24)8-13(15)9-25/h4-5,8,10-11H,3,6-7H2,1-2H3
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Pfizer Inc.

US Patent


Assay Description
The activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximity assay (SPA) modifie...


US Patent US8598155 (2013)


BindingDB Entry DOI: 10.7270/Q26T0K8C
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM107845
PNG
(US8598155, 83)
Show SMILES COC(=O)NC1CN(C1)c1ncnn2c(C)nc(-c3cnn(C)c3-c3ccc(cc3)C(F)(F)F)c12
Show InChI InChI=1S/C22H21F3N8O2/c1-12-29-17(16-8-27-31(2)18(16)13-4-6-14(7-5-13)22(23,24)25)19-20(26-11-28-33(12)19)32-9-15(10-32)30-21(34)35-3/h4-8,11,15H,9-10H2,1-3H3,(H,30,34)
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Pfizer Inc.

US Patent


Assay Description
The activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximity assay (SPA) modifie...


US Patent US8598155 (2013)


BindingDB Entry DOI: 10.7270/Q26T0K8C
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM171890
PNG
(US9085584, 56 | US9085584, 56a | US9085584, 56b | ...)
Show SMILES Cc1nc2ccc(nc2n2c(nnc12)-c1cc(OC2COCC2O)ccc1Cl)C1CC1
Show InChI InChI=1S/C22H20ClN5O3/c1-11-20-26-27-21(28(20)22-17(24-11)7-6-16(25-22)12-2-3-12)14-8-13(4-5-15(14)23)31-19-10-30-9-18(19)29/h4-8,12,18-19,29H,2-3,9-10H2,1H3
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of PDE 2A or 10 enzyme activity was assessed using IMAP-Phosphodiesterase-cAMP fluorescence labeled substrate (Molecular Devices, Orde...


US Patent US9085584 (2015)


BindingDB Entry DOI: 10.7270/Q27P8X54
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50208314
PNG
(CHEMBL3884788)
Show SMILES FC(F)Oc1ccc(cc1OCC1CC1)C(=O)Nc1ccccc1Cl
Show InChI InChI=1S/C18H16ClF2NO3/c19-13-3-1-2-4-14(13)22-17(23)12-7-8-15(25-18(20)21)16(9-12)24-10-11-5-6-11/h1-4,7-9,11,18H,5-6,10H2,(H,22,23)
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Southern Medical University

Curated by ChEMBL


Assay Description
Inhibition of human PDE2A using FAM-3',5'-cAMP as substrate after 1 hr by fluorescence polarization assay


Eur J Med Chem 124: 372-379 (2016)


Article DOI: 10.1016/j.ejmech.2016.08.052
BindingDB Entry DOI: 10.7270/Q29P33N6
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50208315
PNG
(CHEMBL3884224)
Show SMILES FC(F)Oc1ccc(cc1OCC1CC1)C(=O)Nc1cccnc1
Show InChI InChI=1S/C17H16F2N2O3/c18-17(19)24-14-6-5-12(8-15(14)23-10-11-3-4-11)16(22)21-13-2-1-7-20-9-13/h1-2,5-9,11,17H,3-4,10H2,(H,21,22)
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Southern Medical University

Curated by ChEMBL


Assay Description
Inhibition of human PDE2A using FAM-3',5'-cAMP as substrate after 1 hr by fluorescence polarization assay


Eur J Med Chem 124: 372-379 (2016)


Article DOI: 10.1016/j.ejmech.2016.08.052
BindingDB Entry DOI: 10.7270/Q29P33N6
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50208311
PNG
(CHEMBL3885161)
Show SMILES FC(F)Oc1ccc(cc1OC1CCCC1)C(=O)Nc1cccnc1
Show InChI InChI=1S/C18H18F2N2O3/c19-18(20)25-15-8-7-12(10-16(15)24-14-5-1-2-6-14)17(23)22-13-4-3-9-21-11-13/h3-4,7-11,14,18H,1-2,5-6H2,(H,22,23)
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Southern Medical University

Curated by ChEMBL


Assay Description
Inhibition of human PDE2A using FAM-3',5'-cAMP as substrate after 1 hr by fluorescence polarization assay


Eur J Med Chem 124: 372-379 (2016)


Article DOI: 10.1016/j.ejmech.2016.08.052
BindingDB Entry DOI: 10.7270/Q29P33N6
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50208310
PNG
(CHEMBL3883753)
Show SMILES FC(F)Oc1ccc(cc1OC1CCCC1)C(=O)Nc1ccccc1Cl
Show InChI InChI=1S/C19H18ClF2NO3/c20-14-7-3-4-8-15(14)23-18(24)12-9-10-16(26-19(21)22)17(11-12)25-13-5-1-2-6-13/h3-4,7-11,13,19H,1-2,5-6H2,(H,23,24)
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Southern Medical University

Curated by ChEMBL


Assay Description
Inhibition of human PDE2A using FAM-3',5'-cAMP as substrate after 1 hr by fluorescence polarization assay


Eur J Med Chem 124: 372-379 (2016)


Article DOI: 10.1016/j.ejmech.2016.08.052
BindingDB Entry DOI: 10.7270/Q29P33N6
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM171935
PNG
(US9085584, 94)
Show SMILES Cc1nc2ccc(nc2n2c(nnc12)-c1cc(ccc1Cl)C1(O)CCOCC1)C1CC1
Show InChI InChI=1S/C23H22ClN5O2/c1-13-20-27-28-21(29(20)22-19(25-13)7-6-18(26-22)14-2-3-14)16-12-15(4-5-17(16)24)23(30)8-10-31-11-9-23/h4-7,12,14,30H,2-3,8-11H2,1H3
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of PDE 2A or 10 enzyme activity was assessed using IMAP-Phosphodiesterase-cAMP fluorescence labeled substrate (Molecular Devices, Orde...


US Patent US9085584 (2015)


BindingDB Entry DOI: 10.7270/Q27P8X54
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM171932
PNG
(US9085584, 91)
Show SMILES CC(C)c1ccc2nc(C)c3nnc(-c4cc(ccc4Cl)C4(O)CCC4)n3c2n1
Show InChI InChI=1S/C22H22ClN5O/c1-12(2)17-7-8-18-21(25-17)28-19(13(3)24-18)26-27-20(28)15-11-14(5-6-16(15)23)22(29)9-4-10-22/h5-8,11-12,29H,4,9-10H2,1-3H3
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of PDE 2A or 10 enzyme activity was assessed using IMAP-Phosphodiesterase-cAMP fluorescence labeled substrate (Molecular Devices, Orde...


US Patent US9085584 (2015)


BindingDB Entry DOI: 10.7270/Q27P8X54
More data for this
Ligand-Target Pair
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