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Compile Data Set for Download or QSAR

Found 541 hits Enz. Inhib. hit(s) with Target = 'cytosolic phospholipase a2'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM?mit=repeat
Kd
nM
EC50/IC50
nM?mit=repeat
koff
s-1
kon
M-1s-1
pHTemp
°C
cPLA2 C2


(Homo sapiens (Human))
BDBM50056737
PNG
(CHEMBL3327092)
Show SMILES OC(=O)CCc1ccc2n(cc(CCc3ccccc3)c2c1)-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C31H27NO3/c33-31(34)20-13-24-12-19-30-29(21-24)25(14-11-23-7-3-1-4-8-23)22-32(30)26-15-17-28(18-16-26)35-27-9-5-2-6-10-27/h1-10,12,15-19,21-22H,11,13-14,20H2,(H,33,34)
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n/an/a 20n/an/an/an/an/an/a



Asubio Pharma Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cPLA2alpha isolated from human U937 cell cytoplasm assessed as suppression of [14C]arachidonic acid release from L-alpha-1-palmitoyl-2-...


J Med Chem 57: 7244-62 (2014)


Article DOI: 10.1021/jm500494y
BindingDB Entry DOI: 10.7270/Q2F47QSP
More data for this
Ligand-Target Pair
Phospholipase A2 group 1VB


(Homo sapiens (Human))
BDBM50110854
PNG
(4-[3-(4-Decyloxy-phenoxy)-2-oxo-propoxy]-3-nitro-b...)
Show SMILES CCCCCCCCCCOc1ccc(OCC(=O)COc2ccc(cc2[N+]([O-])=O)C(O)=O)cc1
Show InChI InChI=1S/C26H33NO8/c1-2-3-4-5-6-7-8-9-16-33-22-11-13-23(14-12-22)34-18-21(28)19-35-25-15-10-20(26(29)30)17-24(25)27(31)32/h10-15,17H,2-9,16,18-19H2,1H3,(H,29,30)
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n/an/a 20n/an/an/an/an/an/a



AstraZeneca R&D Charnwood

Curated by ChEMBL


Assay Description
Inhibitory activity against cytosolic Phospholipase A2 (PLA2) by soluble assay


J Med Chem 45: 1348-62 (2002)


Article DOI: 10.1021/jm011050x
BindingDB Entry DOI: 10.7270/Q2F76BVP
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (Human))
BDBM50292789
PNG
(4-[3-(5-Chloro-1-(diphenylmethyl)-2-{2-[({2-[(4-me...)
Show SMILES CN1CCN(Cc2ccccc2CS(=O)(=O)NCCc2c(CCCc3ccc(cc3)C(O)=O)c3cc(Cl)ccc3n2C(c2ccccc2)c2ccccc2)CC1
Show InChI InChI=1S/C46H49ClN4O4S/c1-49-27-29-50(30-28-49)32-38-16-8-9-17-39(38)33-56(54,55)48-26-25-44-41(18-10-11-34-19-21-37(22-20-34)46(52)53)42-31-40(47)23-24-43(42)51(44)45(35-12-4-2-5-13-35)36-14-6-3-7-15-36/h2-9,12-17,19-24,31,45,48H,10-11,18,25-30,32-33H2,1H3,(H,52,53)
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n/an/a 20n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human cytosolic PLA2alpha by GLU micelle assay


J Med Chem 52: 1156-71 (2009)


Article DOI: 10.1021/jm8009876
BindingDB Entry DOI: 10.7270/Q20C4VSK
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (Human))
BDBM50185350
PNG
(1-(3-(4-(decyloxy)phenoxy)-2-oxopropyl)-1H-indole-...)
Show SMILES CCCCCCCCCCOc1ccc(OCC(=O)Cn2ccc3cc(ccc23)C(O)=O)cc1
Show InChI InChI=1S/C28H35NO5/c1-2-3-4-5-6-7-8-9-18-33-25-11-13-26(14-12-25)34-21-24(30)20-29-17-16-22-19-23(28(31)32)10-15-27(22)29/h10-17,19H,2-9,18,20-21H2,1H3,(H,31,32)
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n/an/a 20n/an/an/an/an/an/a



University of Münster

Curated by ChEMBL


Assay Description
Inhibition of human isolated cPLA2alpha by vescicle assay


J Med Chem 49: 2611-20 (2006)


Article DOI: 10.1021/jm051243a
BindingDB Entry DOI: 10.7270/Q2668CSF
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (Human))
BDBM50085980
PNG
(CHEMBL428996 | N-{4-(Biphenyl-2-ylmethyl-isobutyl-...)
Show SMILES CC(C)CN(Cc1ccccc1-c1ccccc1)[C@@H]1C[C@@H](CNC(=O)c2ccc(C=C3SC(O)=NC3=O)cc2)N(C1)C(=O)c1ccccc1C(=O)c1ccc(F)cc1
Show InChI InChI=1S/C47H43FN4O5S/c1-30(2)27-51(28-35-12-6-7-13-39(35)32-10-4-3-5-11-32)38-25-37(26-49-44(54)34-18-16-31(17-19-34)24-42-45(55)50-47(57)58-42)52(29-38)46(56)41-15-9-8-14-40(41)43(53)33-20-22-36(48)23-21-33/h3-24,30,37-38H,25-29H2,1-2H3,(H,49,54)(H,50,55,57)/t37-,38+/m0/s1
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n/an/a 21n/an/an/an/an/an/a



Shionogi & Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of Human cPLA2 alpha using Enzyme assay(PC/DOG assay)


J Med Chem 43: 1041-4 (2000)


Article DOI: 10.1021/jm9905155
BindingDB Entry DOI: 10.7270/Q27P8XMZ
More data for this
Ligand-Target Pair
Cytosolic phospholipase A2


(Homo sapiens (Human))
BDBM50233829
PNG
(CHEMBL1801026)
Show SMILES CCCCCCCCc1ccc(OCC(=O)Cn2cc(C(=O)CCCCC(O)=O)c3cc(ccc23)C(O)=O)cc1
Show InChI InChI=1S/C32H39NO7/c1-2-3-4-5-6-7-10-23-13-16-26(17-14-23)40-22-25(34)20-33-21-28(30(35)11-8-9-12-31(36)37)27-19-24(32(38)39)15-18-29(27)33/h13-19,21H,2-12,20,22H2,1H3,(H,36,37)(H,38,39)
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n/an/a 22n/an/an/an/an/an/a



University of M£nster

Curated by ChEMBL


Assay Description
Inhibition of human platelet cytosolic phospholipase alpha-2 using 1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine/1,2-dioleoyl-sn-glycerol as ...


Eur J Med Chem 125: 1107-1114 (2017)


Article DOI: 10.1016/j.ejmech.2016.10.039
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (Human))
BDBM50292793
PNG
(4-(3-{5-Chloro-1-(diphenylmethyl)-2-[2-({[2-(hydro...)
Show SMILES OCc1ccccc1CS(=O)(=O)NCCc1c(CCCc2ccc(cc2)C(O)=O)c2cc(Cl)ccc2n1C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C41H39ClN2O5S/c42-35-22-23-38-37(26-35)36(17-9-10-29-18-20-32(21-19-29)41(46)47)39(24-25-43-50(48,49)28-34-16-8-7-15-33(34)27-45)44(38)40(30-11-3-1-4-12-30)31-13-5-2-6-14-31/h1-8,11-16,18-23,26,40,43,45H,9-10,17,24-25,27-28H2,(H,46,47)
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n/an/a 22n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human cytosolic PLA2alpha by GLU micelle assay


J Med Chem 52: 1156-71 (2009)


Article DOI: 10.1021/jm8009876
BindingDB Entry DOI: 10.7270/Q20C4VSK
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (Human))
BDBM50085997
PNG
(CHEMBL266374 | N-{4-(2-Bromo-6-isobutyl-phenoxy)-1...)
Show SMILES CC(C)Cc1cccc(Br)c1O[C@@H]1C[C@@H](CNC(=O)c2ccc(C=C3SC(O)=NC3=O)cc2)N(C1)C(=O)c1ccccc1C(=O)c1ccc(F)cc1F
Show InChI InChI=1S/C40H34BrF2N3O6S/c1-22(2)16-25-6-5-9-32(41)36(25)52-28-19-27(20-44-37(48)24-12-10-23(11-13-24)17-34-38(49)45-40(51)53-34)46(21-28)39(50)30-8-4-3-7-29(30)35(47)31-15-14-26(42)18-33(31)43/h3-15,17-18,22,27-28H,16,19-21H2,1-2H3,(H,44,48)(H,45,49,51)/t27-,28+/m0/s1
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n/an/a 22n/an/an/an/an/an/a



Shionogi & Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of Human cPLA2 alpha using Enzyme assay(PC/DOG assay)


J Med Chem 43: 1041-4 (2000)


Article DOI: 10.1021/jm9905155
BindingDB Entry DOI: 10.7270/Q27P8XMZ
More data for this
Ligand-Target Pair
Cytosolic phospholipase A2


(Homo sapiens (Human))
BDBM50233837
PNG
(CHEMBL4086908)
Show SMILES CCCCCCCCc1ccc(OCC(=O)Cn2cc(C(=O)CCCO)c3cc(ccc23)C(O)=O)cc1
Show InChI InChI=1S/C30H37NO6/c1-2-3-4-5-6-7-9-22-11-14-25(15-12-22)37-21-24(33)19-31-20-27(29(34)10-8-17-32)26-18-23(30(35)36)13-16-28(26)31/h11-16,18,20,32H,2-10,17,19,21H2,1H3,(H,35,36)
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n/an/a 23n/an/an/an/an/an/a



University of M£nster

Curated by ChEMBL


Assay Description
Inhibition of human platelet cytosolic phospholipase alpha-2 using 1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine/1,2-dioleoyl-sn-glycerol as ...


Eur J Med Chem 125: 1107-1114 (2017)


Article DOI: 10.1016/j.ejmech.2016.10.039
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (Human))
BDBM50277833
PNG
(1-(3-(4-octylphenoxy)-2-oxopropyl)-1H-indazole-6-c...)
Show SMILES CCCCCCCCc1ccc(OCC(=O)Cn2ncc3ccc(cc23)C(O)=O)cc1
Show InChI InChI=1S/C25H30N2O4/c1-2-3-4-5-6-7-8-19-9-13-23(14-10-19)31-18-22(28)17-27-24-15-20(25(29)30)11-12-21(24)16-26-27/h9-16H,2-8,17-18H2,1H3,(H,29,30)
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n/an/a 26n/an/an/an/an/an/a



University of M£nster

Curated by ChEMBL


Assay Description
Inhibition of cPLA2 from human platelets by RP-HPLC


Bioorg Med Chem 18: 945-52 (2010)


Article DOI: 10.1016/j.bmc.2009.11.028
BindingDB Entry DOI: 10.7270/Q2N016MF
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (Human))
BDBM50277798
PNG
(1-(3-(4-octylphenoxy)-2-oxopropyl)-1H-benzo[d][1,2...)
Show SMILES CCCCCCCCc1ccc(OCC(=O)Cn2nnc3cc(ccc23)C(O)=O)cc1
Show InChI InChI=1S/C24H29N3O4/c1-2-3-4-5-6-7-8-18-9-12-21(13-10-18)31-17-20(28)16-27-23-14-11-19(24(29)30)15-22(23)25-26-27/h9-15H,2-8,16-17H2,1H3,(H,29,30)
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n/an/a 26n/an/an/an/an/an/a



University of M£nster

Curated by ChEMBL


Assay Description
Inhibition of cPLA2 from human platelets by RP-HPLC


Bioorg Med Chem 18: 945-52 (2010)


Article DOI: 10.1016/j.bmc.2009.11.028
BindingDB Entry DOI: 10.7270/Q2N016MF
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (Human))
BDBM50277798
PNG
(1-(3-(4-octylphenoxy)-2-oxopropyl)-1H-benzo[d][1,2...)
Show SMILES CCCCCCCCc1ccc(OCC(=O)Cn2nnc3cc(ccc23)C(O)=O)cc1
Show InChI InChI=1S/C24H29N3O4/c1-2-3-4-5-6-7-8-18-9-12-21(13-10-18)31-17-20(28)16-27-23-14-11-19(24(29)30)15-22(23)25-26-27/h9-15H,2-8,16-17H2,1H3,(H,29,30)
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n/an/a 26n/an/an/an/an/an/a



University of M£nster

Curated by ChEMBL


Assay Description
Inhibition of cPLA2 in human platelets assessed as arachidonic acid release


Bioorg Med Chem Lett 19: 2107-11 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.019
BindingDB Entry DOI: 10.7270/Q26H4JB8
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (Human))
BDBM50056709
PNG
(CHEMBL3326969)
Show SMILES COc1ccc(cc1)-n1cc(CCc2ccccc2)c2cc(CCC(O)=O)ccc12
Show InChI InChI=1S/C26H25NO3/c1-30-23-13-11-22(12-14-23)27-18-21(10-7-19-5-3-2-4-6-19)24-17-20(8-15-25(24)27)9-16-26(28)29/h2-6,8,11-15,17-18H,7,9-10,16H2,1H3,(H,28,29)
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n/an/a 26n/an/an/an/an/an/a



Asubio Pharma Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cPLA2alpha isolated from human U937 cell cytoplasm assessed as suppression of [14C]arachidonic acid release from L-alpha-1-palmitoyl-2-...


J Med Chem 57: 7244-62 (2014)


Article DOI: 10.1021/jm500494y
BindingDB Entry DOI: 10.7270/Q2F47QSP
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (Human))
BDBM50247699
PNG
(4-(3-(1-benzhydryl-5-chloro-2-(2-(o-tolylmethylsul...)
Show SMILES Cc1ccccc1CS(=O)(=O)NCCc1c(CCCc2ccc(cc2)C(O)=O)c2cc(Cl)ccc2n1C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C41H39ClN2O4S/c1-29-11-8-9-17-34(29)28-49(47,48)43-26-25-39-36(18-10-12-30-19-21-33(22-20-30)41(45)46)37-27-35(42)23-24-38(37)44(39)40(31-13-4-2-5-14-31)32-15-6-3-7-16-32/h2-9,11,13-17,19-24,27,40,43H,10,12,18,25-26,28H2,1H3,(H,45,46)
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n/an/a 26n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human cytosolic PLA2alpha by GLU micelle assay


J Med Chem 52: 1156-71 (2009)


Article DOI: 10.1021/jm8009876
BindingDB Entry DOI: 10.7270/Q20C4VSK
More data for this
Ligand-Target Pair
Phospholipase A2 group 1VB


(Homo sapiens (Human))
BDBM50110873
PNG
(4-[3-(4-Dodecyloxy-phenoxy)-2-oxo-propoxy]-benzoic...)
Show SMILES CCCCCCCCCCCCOc1ccc(OCC(=O)COc2ccc(cc2)C(O)=O)cc1
Show InChI InChI=1S/C28H38O6/c1-2-3-4-5-6-7-8-9-10-11-20-32-25-16-18-27(19-17-25)34-22-24(29)21-33-26-14-12-23(13-15-26)28(30)31/h12-19H,2-11,20-22H2,1H3,(H,30,31)
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AstraZeneca R&D Charnwood

Curated by ChEMBL


Assay Description
Inhibitory activity against cytosolic Phospholipase A2 (PLA2) by soluble assay


J Med Chem 45: 1348-62 (2002)


Article DOI: 10.1021/jm011050x
BindingDB Entry DOI: 10.7270/Q2F76BVP
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (Human))
BDBM50277833
PNG
(1-(3-(4-octylphenoxy)-2-oxopropyl)-1H-indazole-6-c...)
Show SMILES CCCCCCCCc1ccc(OCC(=O)Cn2ncc3ccc(cc23)C(O)=O)cc1
Show InChI InChI=1S/C25H30N2O4/c1-2-3-4-5-6-7-8-19-9-13-23(14-10-19)31-18-22(28)17-27-24-15-20(25(29)30)11-12-21(24)16-26-27/h9-16H,2-8,17-18H2,1H3,(H,29,30)
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n/an/a 26n/an/an/an/an/an/a



University of M£nster

Curated by ChEMBL


Assay Description
Inhibition of cPLA2 in human platelets assessed as arachidonic acid release


Bioorg Med Chem Lett 19: 2107-11 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.019
BindingDB Entry DOI: 10.7270/Q26H4JB8
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (Human))
BDBM50056739
PNG
(CHEMBL3327090)
Show SMILES OC(=O)CCc1ccc2n(cc(CCc3ccccc3)c2c1)-c1ccc(OC(F)F)cc1
Show InChI InChI=1S/C26H23F2NO3/c27-26(28)32-22-12-10-21(11-13-22)29-17-20(9-6-18-4-2-1-3-5-18)23-16-19(7-14-24(23)29)8-15-25(30)31/h1-5,7,10-14,16-17,26H,6,8-9,15H2,(H,30,31)
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n/an/a 28n/an/an/an/an/an/a



Asubio Pharma Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cPLA2alpha isolated from human U937 cell cytoplasm assessed as suppression of [14C]arachidonic acid release from L-alpha-1-palmitoyl-2-...


J Med Chem 57: 7244-62 (2014)


Article DOI: 10.1021/jm500494y
BindingDB Entry DOI: 10.7270/Q2F47QSP
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (Human))
BDBM50292794
PNG
(4-{3-[5-Chloro-2-{2-[({2-[(diethylamino)methyl]ben...)
Show SMILES CCN(CC)Cc1ccccc1CS(=O)(=O)NCCc1c(CCCc2ccc(cc2)C(O)=O)c2cc(Cl)ccc2n1C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C45H48ClN3O4S/c1-3-48(4-2)31-37-19-11-12-20-38(37)32-54(52,53)47-29-28-43-40(21-13-14-33-22-24-36(25-23-33)45(50)51)41-30-39(46)26-27-42(41)49(43)44(34-15-7-5-8-16-34)35-17-9-6-10-18-35/h5-12,15-20,22-27,30,44,47H,3-4,13-14,21,28-29,31-32H2,1-2H3,(H,50,51)
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n/an/a 30n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human cytosolic PLA2alpha by GLU micelle assay


J Med Chem 52: 1156-71 (2009)


Article DOI: 10.1021/jm8009876
BindingDB Entry DOI: 10.7270/Q20C4VSK
More data for this
Ligand-Target Pair
Phospholipase A2 group 1VB


(Homo sapiens (Human))
BDBM50110875
PNG
(5-[3-(4-Decyloxy-phenoxy)-2-oxo-propoxy]-pentanoic...)
Show SMILES CCCCCCCCCCOc1ccc(OCC(=O)COCCCCC(O)=O)cc1
Show InChI InChI=1S/C24H38O6/c1-2-3-4-5-6-7-8-10-18-29-22-13-15-23(16-14-22)30-20-21(25)19-28-17-11-9-12-24(26)27/h13-16H,2-12,17-20H2,1H3,(H,26,27)
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n/an/a 30n/an/an/an/an/an/a



AstraZeneca R&D Charnwood

Curated by ChEMBL


Assay Description
Inhibitory activity against cytosolic Phospholipase A2 (PLA2) by soluble assay


J Med Chem 45: 1348-62 (2002)


Article DOI: 10.1021/jm011050x
BindingDB Entry DOI: 10.7270/Q2F76BVP
More data for this
Ligand-Target Pair
Phospholipase A2 group 1VB


(Homo sapiens (Human))
BDBM50110846
PNG
(4-(3-(4-(decyloxy)phenoxy)-2-oxopropoxy)benzoic ac...)
Show SMILES CCCCCCCCCCOc1ccc(OCC(=O)COc2ccc(cc2)C(O)=O)cc1
Show InChI InChI=1S/C26H34O6/c1-2-3-4-5-6-7-8-9-18-30-23-14-16-25(17-15-23)32-20-22(27)19-31-24-12-10-21(11-13-24)26(28)29/h10-17H,2-9,18-20H2,1H3,(H,28,29)
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n/an/a 30n/an/an/an/an/an/a



AstraZeneca R&D Charnwood

Curated by ChEMBL


Assay Description
Inhibitory activity against cytosolic Phospholipase A2 (PLA2) by soluble assay


J Med Chem 45: 1348-62 (2002)


Article DOI: 10.1021/jm011050x
BindingDB Entry DOI: 10.7270/Q2F76BVP
More data for this
Ligand-Target Pair
Cytosolic phospholipase A2


(Homo sapiens (Human))
BDBM50233830
PNG
(CHEMBL4067166)
Show SMILES CCCCCCCCc1ccc(OCC(=O)Cn2cc(C(=O)CCCCCO)c3cc(ccc23)C(O)=O)cc1
Show InChI InChI=1S/C32H41NO6/c1-2-3-4-5-6-8-11-24-13-16-27(17-14-24)39-23-26(35)21-33-22-29(31(36)12-9-7-10-19-34)28-20-25(32(37)38)15-18-30(28)33/h13-18,20,22,34H,2-12,19,21,23H2,1H3,(H,37,38)
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n/an/a 31n/an/an/an/an/an/a



University of M£nster

Curated by ChEMBL


Assay Description
Inhibition of human platelet cytosolic phospholipase alpha-2 using 1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine/1,2-dioleoyl-sn-glycerol as ...


Eur J Med Chem 125: 1107-1114 (2017)


Article DOI: 10.1016/j.ejmech.2016.10.039
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (Human))
BDBM50085993
PNG
((E)-N-(((2S,4R)-4-((biphenyl-2-ylmethyl)(isobutyl)...)
Show SMILES CC(C)CN(Cc1ccccc1-c1ccccc1)[C@@H]1C[C@@H](CNC(=O)C=Cc2ccc(C=C3SC(O)=NC3=O)cc2)N(C1)C(=O)c1ccccc1C(=O)c1ccc(F)cc1F
Show InChI InChI=1S/C49H44F2N4O5S/c1-31(2)28-54(29-35-12-6-7-13-39(35)34-10-4-3-5-11-34)38-26-37(27-52-45(56)23-20-32-16-18-33(19-17-32)24-44-47(58)53-49(60)61-44)55(30-38)48(59)41-15-9-8-14-40(41)46(57)42-22-21-36(50)25-43(42)51/h3-25,31,37-38H,26-30H2,1-2H3,(H,52,56)(H,53,58,60)/t37-,38+/m0/s1
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n/an/a 31n/an/an/an/an/an/a



University of M£nster

Curated by ChEMBL


Assay Description
Inhibition of cPLA2 from human platelets by RP-HPLC


Bioorg Med Chem 18: 945-52 (2010)


Article DOI: 10.1016/j.bmc.2009.11.028
BindingDB Entry DOI: 10.7270/Q2N016MF
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (Human))
BDBM50085990
PNG
(CHEMBL268434 | N-{4-(Biphenyl-2-ylmethylsulfanyl)-...)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(cc1)C(=O)NC[C@@H]1C[C@H](CN1C(=O)c1ccccc1C(=O)c1ccc(F)cc1)SCc1ccccc1-c1ccccc1
Show InChI InChI=1S/C43H34FN3O5S2/c44-32-20-18-29(19-21-32)39(48)36-12-6-7-13-37(36)42(51)47-25-34(53-26-31-10-4-5-11-35(31)28-8-2-1-3-9-28)23-33(47)24-45-40(49)30-16-14-27(15-17-30)22-38-41(50)46-43(52)54-38/h1-22,33-34H,23-26H2,(H,45,49)(H,46,50,52)/t33-,34+/m0/s1
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n/an/a 34n/an/an/an/an/an/a



Shionogi & Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of Human cPLA2 alpha using Enzyme assay(PC/DOG assay)


J Med Chem 43: 1041-4 (2000)


Article DOI: 10.1021/jm9905155
BindingDB Entry DOI: 10.7270/Q27P8XMZ
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (Human))
BDBM50185356
PNG
(1-(3-(4-octylphenoxy)-2-oxopropyl)-1H-indole-5-car...)
Show SMILES CCCCCCCCc1ccc(OCC(=O)Cn2ccc3cc(ccc23)C(O)=O)cc1
Show InChI InChI=1S/C26H31NO4/c1-2-3-4-5-6-7-8-20-9-12-24(13-10-20)31-19-23(28)18-27-16-15-21-17-22(26(29)30)11-14-25(21)27/h9-17H,2-8,18-19H2,1H3,(H,29,30)
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n/an/a 35n/an/an/an/an/an/a



University of M£nster

Curated by ChEMBL


Assay Description
Inhibition of cPLA2 from human platelets by RP-HPLC


Bioorg Med Chem 18: 945-52 (2010)


Article DOI: 10.1016/j.bmc.2009.11.028
BindingDB Entry DOI: 10.7270/Q2N016MF
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (Human))
BDBM50185356
PNG
(1-(3-(4-octylphenoxy)-2-oxopropyl)-1H-indole-5-car...)
Show SMILES CCCCCCCCc1ccc(OCC(=O)Cn2ccc3cc(ccc23)C(O)=O)cc1
Show InChI InChI=1S/C26H31NO4/c1-2-3-4-5-6-7-8-20-9-12-24(13-10-20)31-19-23(28)18-27-16-15-21-17-22(26(29)30)11-14-25(21)27/h9-17H,2-8,18-19H2,1H3,(H,29,30)
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n/an/a 35n/an/an/an/an/an/a



University of M£nster

Curated by ChEMBL


Assay Description
Inhibition of human platelet cPLA2-alpha activity


Bioorg Med Chem 16: 3489-500 (2008)


Article DOI: 10.1016/j.bmc.2008.02.019
BindingDB Entry DOI: 10.7270/Q2W66MN0
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (Human))
BDBM50185356
PNG
(1-(3-(4-octylphenoxy)-2-oxopropyl)-1H-indole-5-car...)
Show SMILES CCCCCCCCc1ccc(OCC(=O)Cn2ccc3cc(ccc23)C(O)=O)cc1
Show InChI InChI=1S/C26H31NO4/c1-2-3-4-5-6-7-8-20-9-12-24(13-10-20)31-19-23(28)18-27-16-15-21-17-22(26(29)30)11-14-25(21)27/h9-17H,2-8,18-19H2,1H3,(H,29,30)
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n/an/a 35n/an/an/an/an/an/a



University of M£nster

Curated by ChEMBL


Assay Description
Inhibition of cPLA2 in human platelets assessed as arachidonic acid release


Bioorg Med Chem Lett 19: 2107-11 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.019
BindingDB Entry DOI: 10.7270/Q26H4JB8
More data for this
Ligand-Target Pair
Phospholipase A2 group 1VB


(Homo sapiens (Human))
BDBM50110865
PNG
(3-[3-(4-Decyloxy-phenoxy)-2-oxo-propoxymethyl]-ben...)
Show SMILES CCCCCCCCCCOc1ccc(OCC(=O)COCc2cccc(c2)C(O)=O)cc1
Show InChI InChI=1S/C27H36O6/c1-2-3-4-5-6-7-8-9-17-32-25-13-15-26(16-14-25)33-21-24(28)20-31-19-22-11-10-12-23(18-22)27(29)30/h10-16,18H,2-9,17,19-21H2,1H3,(H,29,30)
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n/an/a 35n/an/an/an/an/an/a



AstraZeneca R&D Charnwood

Curated by ChEMBL


Assay Description
Inhibitory activity against cytosolic Phospholipase A2 (PLA2) by soluble assay


J Med Chem 45: 1348-62 (2002)


Article DOI: 10.1021/jm011050x
BindingDB Entry DOI: 10.7270/Q2F76BVP
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (Human))
BDBM50185356
PNG
(1-(3-(4-octylphenoxy)-2-oxopropyl)-1H-indole-5-car...)
Show SMILES CCCCCCCCc1ccc(OCC(=O)Cn2ccc3cc(ccc23)C(O)=O)cc1
Show InChI InChI=1S/C26H31NO4/c1-2-3-4-5-6-7-8-20-9-12-24(13-10-20)31-19-23(28)18-27-16-15-21-17-22(26(29)30)11-14-25(21)27/h9-17H,2-8,18-19H2,1H3,(H,29,30)
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n/an/a 35n/an/an/an/an/an/a



University of Münster

Curated by ChEMBL


Assay Description
Inhibition of human isolated cPLA2alpha by vescicle assay


J Med Chem 49: 2611-20 (2006)


Article DOI: 10.1021/jm051243a
BindingDB Entry DOI: 10.7270/Q2668CSF
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (Human))
BDBM50185356
PNG
(1-(3-(4-octylphenoxy)-2-oxopropyl)-1H-indole-5-car...)
Show SMILES CCCCCCCCc1ccc(OCC(=O)Cn2ccc3cc(ccc23)C(O)=O)cc1
Show InChI InChI=1S/C26H31NO4/c1-2-3-4-5-6-7-8-20-9-12-24(13-10-20)31-19-23(28)18-27-16-15-21-17-22(26(29)30)11-14-25(21)27/h9-17H,2-8,18-19H2,1H3,(H,29,30)
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n/an/a 35n/an/an/an/an/an/a



University of Münster

Curated by ChEMBL


Assay Description
Inhibition of human platelet cPLA2-alpha assessed as arachidonic acid release by vesicle assay


Bioorg Med Chem 15: 2883-91 (2007)


Article DOI: 10.1016/j.bmc.2007.02.016
BindingDB Entry DOI: 10.7270/Q24749JP
More data for this
Ligand-Target Pair
Cytosolic phospholipase A2


(Homo sapiens (Human))
BDBM50185356
PNG
(1-(3-(4-octylphenoxy)-2-oxopropyl)-1H-indole-5-car...)
Show SMILES CCCCCCCCc1ccc(OCC(=O)Cn2ccc3cc(ccc23)C(O)=O)cc1
Show InChI InChI=1S/C26H31NO4/c1-2-3-4-5-6-7-8-20-9-12-24(13-10-20)31-19-23(28)18-27-16-15-21-17-22(26(29)30)11-14-25(21)27/h9-17H,2-8,18-19H2,1H3,(H,29,30)
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n/an/a 35n/an/an/an/an/an/a



University of M£nster

Curated by ChEMBL


Assay Description
Inhibition of human platelet cytosolic phospholipase alpha-2 using 1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine/1,2-dioleoyl-sn-glycerol as ...


Eur J Med Chem 125: 1107-1114 (2017)


Article DOI: 10.1016/j.ejmech.2016.10.039
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (Human))
BDBM50056732
PNG
(CHEMBL3327094)
Show SMILES OC(=O)CCc1ccc2n(cc(CCc3ccccc3)c2c1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C25H22ClNO2/c26-21-10-12-22(13-11-21)27-17-20(9-6-18-4-2-1-3-5-18)23-16-19(7-14-24(23)27)8-15-25(28)29/h1-5,7,10-14,16-17H,6,8-9,15H2,(H,28,29)
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n/an/a 36n/an/an/an/an/an/a



Asubio Pharma Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cPLA2alpha isolated from human U937 cell cytoplasm assessed as suppression of [14C]arachidonic acid release from L-alpha-1-palmitoyl-2-...


J Med Chem 57: 7244-62 (2014)


Article DOI: 10.1021/jm500494y
BindingDB Entry DOI: 10.7270/Q2F47QSP
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (Human))
BDBM50085991
PNG
(CHEMBL268896 | N-{4-(2-Bromo-6-isobutyl-phenoxy)-1...)
Show SMILES CC(C)Cc1cccc(Br)c1O[C@@H]1C[C@@H](CNC(=O)c2ccc(C=C3SC(O)=NC3=O)cc2)N(C1)C(=O)c1ccccc1C(=O)c1ccc(F)cc1
Show InChI InChI=1S/C40H35BrFN3O6S/c1-23(2)18-27-6-5-9-33(41)36(27)51-30-20-29(21-43-37(47)26-12-10-24(11-13-26)19-34-38(48)44-40(50)52-34)45(22-30)39(49)32-8-4-3-7-31(32)35(46)25-14-16-28(42)17-15-25/h3-17,19,23,29-30H,18,20-22H2,1-2H3,(H,43,47)(H,44,48,50)/t29-,30+/m0/s1
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n/an/a 38n/an/an/an/an/an/a



Shionogi & Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of Human cPLA2 alpha using Enzyme assay(PC/DOG assay)


J Med Chem 43: 1041-4 (2000)


Article DOI: 10.1021/jm9905155
BindingDB Entry DOI: 10.7270/Q27P8XMZ
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (Human))
BDBM50110881
PNG
(4-(2-oxo-3-(4-(5-phenylpentylthio)phenoxy)propoxy)...)
Show SMILES OC(=O)c1ccc(OCC(=O)COc2ccc(SCCCCCc3ccccc3)cc2)cc1
Show InChI InChI=1S/C27H28O5S/c28-23(19-31-24-12-10-22(11-13-24)27(29)30)20-32-25-14-16-26(17-15-25)33-18-6-2-5-9-21-7-3-1-4-8-21/h1,3-4,7-8,10-17H,2,5-6,9,18-20H2,(H,29,30)
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n/an/a 40n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of cytosolic phospholipase A2-alpha in GLU micelle assay


J Med Chem 49: 135-58 (2006)


Article DOI: 10.1021/jm0507882
BindingDB Entry DOI: 10.7270/Q2MC8ZMP
More data for this
Ligand-Target Pair
Phospholipase A2 group 1VB


(Homo sapiens (Human))
BDBM50110872
PNG
(4-[3-(4-Decyloxy-phenoxy)-2-oxo-propoxymethyl]-ben...)
Show SMILES CCCCCCCCCCOc1ccc(OCC(=O)COCc2ccc(cc2)C(O)=O)cc1
Show InChI InChI=1S/C27H36O6/c1-2-3-4-5-6-7-8-9-18-32-25-14-16-26(17-15-25)33-21-24(28)20-31-19-22-10-12-23(13-11-22)27(29)30/h10-17H,2-9,18-21H2,1H3,(H,29,30)
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n/an/a 40n/an/an/an/an/an/a



AstraZeneca R&D Charnwood

Curated by ChEMBL


Assay Description
Inhibitory activity against cytosolic Phospholipase A2 (PLA2) by soluble assay


J Med Chem 45: 1348-62 (2002)


Article DOI: 10.1021/jm011050x
BindingDB Entry DOI: 10.7270/Q2F76BVP
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (Human))
BDBM50226792
PNG
(4-(3-(1-benzhydryl-5-chloro-2-(2-((3,4-dichlorophe...)
Show SMILES OC(=O)c1ccc(CCCc2c(CCNS(=O)(=O)Cc3ccc(Cl)c(Cl)c3)n(C(c3ccccc3)c3ccccc3)c3ccc(Cl)cc23)cc1
Show InChI InChI=1S/C40H35Cl3N2O4S/c41-32-19-21-37-34(25-32)33(13-7-8-27-14-17-31(18-15-27)40(46)47)38(22-23-44-50(48,49)26-28-16-20-35(42)36(43)24-28)45(37)39(29-9-3-1-4-10-29)30-11-5-2-6-12-30/h1-6,9-12,14-21,24-25,39,44H,7-8,13,22-23,26H2,(H,46,47)
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n/an/a 40n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human cytosolic PLA2alpha by GLU micelle assay


J Med Chem 52: 1156-71 (2009)


Article DOI: 10.1021/jm8009876
BindingDB Entry DOI: 10.7270/Q20C4VSK
More data for this
Ligand-Target Pair
Phospholipase A2 group 1VB


(Homo sapiens (Human))
BDBM50110884
PNG
(4-[3-(4-Octyloxy-phenoxy)-2-oxo-propoxy]-benzoic a...)
Show SMILES CCCCCCCCOc1ccc(OCC(=O)COc2ccc(cc2)C(O)=O)cc1
Show InChI InChI=1S/C24H30O6/c1-2-3-4-5-6-7-16-28-21-12-14-23(15-13-21)30-18-20(25)17-29-22-10-8-19(9-11-22)24(26)27/h8-15H,2-7,16-18H2,1H3,(H,26,27)
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n/an/a 46n/an/an/an/an/an/a



AstraZeneca R&D Charnwood

Curated by ChEMBL


Assay Description
Inhibitory activity against cytosolic Phospholipase A2 (PLA2) by soluble assay


J Med Chem 45: 1348-62 (2002)


Article DOI: 10.1021/jm011050x
BindingDB Entry DOI: 10.7270/Q2F76BVP
More data for this
Ligand-Target Pair
Phospholipase A2 group 1VB


(Homo sapiens (Human))
BDBM50110879
PNG
(4-{2-Oxo-3-[4-(5-phenyl-pentyloxy)-phenoxy]-propox...)
Show SMILES OC(=O)c1ccc(OCC(=O)COc2ccc(OCCCCCc3ccccc3)cc2)cc1
Show InChI InChI=1S/C27H28O6/c28-23(19-32-25-12-10-22(11-13-25)27(29)30)20-33-26-16-14-24(15-17-26)31-18-6-2-5-9-21-7-3-1-4-8-21/h1,3-4,7-8,10-17H,2,5-6,9,18-20H2,(H,29,30)
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n/an/a 48n/an/an/an/an/an/a



AstraZeneca R&D Charnwood

Curated by ChEMBL


Assay Description
Inhibitory activity against cytosolic Phospholipase A2 (PLA2) by soluble assay


J Med Chem 45: 1348-62 (2002)


Article DOI: 10.1021/jm011050x
BindingDB Entry DOI: 10.7270/Q2F76BVP
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (Human))
BDBM50085983
PNG
(CHEMBL267697 | N-{4-(Biphenyl-2-ylmethoxy)-1-[2-(2...)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(cc1)C(=O)NC[C@@H]1C[C@H](CN1C(=O)c1ccccc1C(=O)c1ccc(F)cc1F)OCc1ccccc1-c1ccccc1
Show InChI InChI=1S/C43H33F2N3O6S/c44-30-18-19-36(37(45)21-30)39(49)34-12-6-7-13-35(34)42(52)48-24-32(54-25-29-10-4-5-11-33(29)27-8-2-1-3-9-27)22-31(48)23-46-40(50)28-16-14-26(15-17-28)20-38-41(51)47-43(53)55-38/h1-21,31-32H,22-25H2,(H,46,50)(H,47,51,53)/t31-,32+/m0/s1
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n/an/a 49n/an/an/an/an/an/a



Shionogi & Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of Human cPLA2 alpha using Enzyme assay(PC/DOG assay)


J Med Chem 43: 1041-4 (2000)


Article DOI: 10.1021/jm9905155
BindingDB Entry DOI: 10.7270/Q27P8XMZ
More data for this
Ligand-Target Pair
Cytosolic phospholipase A2


(Homo sapiens (Human))
BDBM50233836
PNG
(CHEMBL4100466)
Show SMILES CCCCCCCCc1ccc(OCC(=O)Cn2cc(C(=O)CCCCCOC)c3cc(ccc23)C(O)=O)cc1
Show InChI InChI=1S/C33H43NO6/c1-3-4-5-6-7-9-12-25-14-17-28(18-15-25)40-24-27(35)22-34-23-30(32(36)13-10-8-11-20-39-2)29-21-26(33(37)38)16-19-31(29)34/h14-19,21,23H,3-13,20,22,24H2,1-2H3,(H,37,38)
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n/an/a 49n/an/an/an/an/an/a



University of M£nster

Curated by ChEMBL


Assay Description
Inhibition of human platelet cytosolic phospholipase alpha-2 using 1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine/1,2-dioleoyl-sn-glycerol as ...


Eur J Med Chem 125: 1107-1114 (2017)


Article DOI: 10.1016/j.ejmech.2016.10.039
More data for this
Ligand-Target Pair
Phospholipase A2 group 1VB


(Homo sapiens (Human))
BDBM50110888
PNG
(3-[3-(4-Decyloxy-phenoxy)-2-oxo-propoxy]-benzoic a...)
Show SMILES CCCCCCCCCCOc1ccc(OCC(=O)COc2cccc(c2)C(O)=O)cc1
Show InChI InChI=1S/C26H34O6/c1-2-3-4-5-6-7-8-9-17-30-23-13-15-24(16-14-23)31-19-22(27)20-32-25-12-10-11-21(18-25)26(28)29/h10-16,18H,2-9,17,19-20H2,1H3,(H,28,29)
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n/an/a 50n/an/an/an/an/an/a



AstraZeneca R&D Charnwood

Curated by ChEMBL


Assay Description
Inhibitory activity against cytosolic Phospholipase A2 (PLA2) by soluble assay


J Med Chem 45: 1348-62 (2002)


Article DOI: 10.1021/jm011050x
BindingDB Entry DOI: 10.7270/Q2F76BVP
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (Human))
BDBM50205525
PNG
(4-{2-[5-Chloro-2-(2-{[(2-chlorobenzyl)sulfonyl]ami...)
Show SMILES OC(=O)c1ccc(OCCc2c(CCNS(=O)(=O)Cc3ccccc3Cl)n(C(c3ccccc3)c3ccccc3)c3ccc(Cl)cc23)cc1
Show InChI InChI=1S/C39H34Cl2N2O5S/c40-31-17-20-36-34(25-31)33(22-24-48-32-18-15-29(16-19-32)39(44)45)37(21-23-42-49(46,47)26-30-13-7-8-14-35(30)41)43(36)38(27-9-3-1-4-10-27)28-11-5-2-6-12-28/h1-20,25,38,42H,21-24,26H2,(H,44,45)
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n/an/a 52n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human cPLA2 alpha by GLU micelle assay


J Med Chem 50: 1380-400 (2007)


Article DOI: 10.1021/jm061131z
BindingDB Entry DOI: 10.7270/Q23F4PB9
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (Human))
BDBM50056733
PNG
(CHEMBL3327095)
Show SMILES OC(=O)CCc1ccc2n(cc(CCc3ccccc3)c2c1)-c1ccc(F)cc1
Show InChI InChI=1S/C25H22FNO2/c26-21-10-12-22(13-11-21)27-17-20(9-6-18-4-2-1-3-5-18)23-16-19(7-14-24(23)27)8-15-25(28)29/h1-5,7,10-14,16-17H,6,8-9,15H2,(H,28,29)
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n/an/a 58n/an/an/an/an/an/a



Asubio Pharma Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cPLA2alpha isolated from human U937 cell cytoplasm assessed as suppression of [14C]arachidonic acid release from L-alpha-1-palmitoyl-2-...


J Med Chem 57: 7244-62 (2014)


Article DOI: 10.1021/jm500494y
BindingDB Entry DOI: 10.7270/Q2F47QSP
More data for this
Ligand-Target Pair
Phospholipase A2 group 1VB


(Homo sapiens (Human))
BDBM50110860
PNG
(CHEMBL29247 | {3-[3-(4-Decyloxy-phenoxy)-2-oxo-pro...)
Show SMILES CCCCCCCCCCOc1ccc(OCC(=O)COc2cccc(CC(O)=O)c2)cc1
Show InChI InChI=1S/C27H36O6/c1-2-3-4-5-6-7-8-9-17-31-24-13-15-25(16-14-24)32-20-23(28)21-33-26-12-10-11-22(18-26)19-27(29)30/h10-16,18H,2-9,17,19-21H2,1H3,(H,29,30)
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n/an/a 60n/an/an/an/an/an/a



AstraZeneca R&D Charnwood

Curated by ChEMBL


Assay Description
Inhibitory activity against cytosolic Phospholipase A2 (PLA2) by soluble assay


J Med Chem 45: 1348-62 (2002)


Article DOI: 10.1021/jm011050x
BindingDB Entry DOI: 10.7270/Q2F76BVP
More data for this
Ligand-Target Pair
Phospholipase A2 group 1VB


(Homo sapiens (Human))
BDBM50110853
PNG
(CHEMBL29246 | {3-[3-(4-Decyloxy-phenoxy)-2-oxo-pro...)
Show SMILES CCCCCCCCCCOc1ccc(OCC(=O)COc2cccc(OCC(O)=O)c2)cc1
Show InChI InChI=1S/C27H36O7/c1-2-3-4-5-6-7-8-9-17-31-23-13-15-24(16-14-23)32-19-22(28)20-33-25-11-10-12-26(18-25)34-21-27(29)30/h10-16,18H,2-9,17,19-21H2,1H3,(H,29,30)
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n/an/a 60n/an/an/an/an/an/a



AstraZeneca R&D Charnwood

Curated by ChEMBL


Assay Description
Inhibitory activity against cytosolic Phospholipase A2 (PLA2) by bilayer assay


J Med Chem 45: 1348-62 (2002)


Article DOI: 10.1021/jm011050x
BindingDB Entry DOI: 10.7270/Q2F76BVP
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (Human))
BDBM50085988
PNG
(CHEMBL416517 | N-{4-(Biphenyl-2-yloxy)-1-[2-(4-flu...)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(cc1)C(=O)NC[C@@H]1C[C@H](CN1C(=O)c1ccccc1C(=O)c1ccc(F)cc1)Oc1ccccc1-c1ccccc1
Show InChI InChI=1S/C42H32FN3O6S/c43-30-20-18-28(19-21-30)38(47)34-11-4-5-12-35(34)41(50)46-25-32(52-36-13-7-6-10-33(36)27-8-2-1-3-9-27)23-31(46)24-44-39(48)29-16-14-26(15-17-29)22-37-40(49)45-42(51)53-37/h1-22,31-32H,23-25H2,(H,44,48)(H,45,49,51)/t31-,32+/m0/s1
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n/an/a 69n/an/an/an/an/an/a



Shionogi & Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of Human cPLA2 alpha using Enzyme assay(PC/DOG assay)


J Med Chem 43: 1041-4 (2000)


Article DOI: 10.1021/jm9905155
BindingDB Entry DOI: 10.7270/Q27P8XMZ
More data for this
Ligand-Target Pair
Phospholipase A2 group 1VB


(Homo sapiens (Human))
BDBM50110863
PNG
(5-[3-(4-Decyloxy-phenoxy)-2-oxo-propylsulfanyl]-pe...)
Show SMILES CCCCCCCCCCOc1ccc(OCC(=O)CSCCCCC(O)=O)cc1
Show InChI InChI=1S/C24H38O5S/c1-2-3-4-5-6-7-8-10-17-28-22-13-15-23(16-14-22)29-19-21(25)20-30-18-11-9-12-24(26)27/h13-16H,2-12,17-20H2,1H3,(H,26,27)
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n/an/a 70n/an/an/an/an/an/a



AstraZeneca R&D Charnwood

Curated by ChEMBL


Assay Description
Inhibitory activity against cytosolic Phospholipase A2 (PLA2) by soluble assay


J Med Chem 45: 1348-62 (2002)


Article DOI: 10.1021/jm011050x
BindingDB Entry DOI: 10.7270/Q2F76BVP
More data for this
Ligand-Target Pair
Cytosolic phospholipase A2


(Homo sapiens (Human))
BDBM50233838
PNG
(CHEMBL1800992)
Show SMILES CCCCCCCCc1ccc(OCC(=O)Cn2cc(C(=O)CCCCC)c3cc(ccc23)C(O)=O)cc1
Show InChI InChI=1S/C32H41NO5/c1-3-5-7-8-9-11-12-24-14-17-27(18-15-24)38-23-26(34)21-33-22-29(31(35)13-10-6-4-2)28-20-25(32(36)37)16-19-30(28)33/h14-20,22H,3-13,21,23H2,1-2H3,(H,36,37)
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n/an/a 71n/an/an/an/an/an/a



University of M£nster

Curated by ChEMBL


Assay Description
Inhibition of human platelet cytosolic phospholipase alpha-2 using 1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine/1,2-dioleoyl-sn-glycerol as ...


Eur J Med Chem 125: 1107-1114 (2017)


Article DOI: 10.1016/j.ejmech.2016.10.039
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (Human))
BDBM50085981
PNG
(CHEMBL268419 | N-{4-(Biphenyl-2-ylmethylsulfanyl)-...)
Show SMILES Fc1ccc(cc1)C(=O)c1ccccc1C(=O)N1C[C@@H](C[C@H]1CNC(=O)c1ccc(C=C2SC(S)=NC2=O)cc1)SCc1ccccc1-c1ccccc1
Show InChI InChI=1S/C43H34FN3O4S3/c44-32-20-18-29(19-21-32)39(48)36-12-6-7-13-37(36)42(51)47-25-34(53-26-31-10-4-5-11-35(31)28-8-2-1-3-9-28)23-33(47)24-45-40(49)30-16-14-27(15-17-30)22-38-41(50)46-43(52)54-38/h1-22,33-34H,23-26H2,(H,45,49)(H,46,50,52)/t33-,34+/m0/s1
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n/an/a 72n/an/an/an/an/an/a



Shionogi & Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of Human cPLA2 alpha using Enzyme assay(PC/DOG assay)


J Med Chem 43: 1041-4 (2000)


Article DOI: 10.1021/jm9905155
BindingDB Entry DOI: 10.7270/Q27P8XMZ
More data for this
Ligand-Target Pair
Phospholipase A2 group 1VB


(Homo sapiens (Human))
BDBM50110871
PNG
(4-[3-(4-Decyloxy-phenoxy)-2-oxo-propoxy]-3-methoxy...)
Show SMILES CCCCCCCCCCOc1ccc(OCC(=O)COc2ccc(cc2OC)C(O)=O)cc1
Show InChI InChI=1S/C27H36O7/c1-3-4-5-6-7-8-9-10-17-32-23-12-14-24(15-13-23)33-19-22(28)20-34-25-16-11-21(27(29)30)18-26(25)31-2/h11-16,18H,3-10,17,19-20H2,1-2H3,(H,29,30)
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n/an/a 74n/an/an/an/an/an/a



AstraZeneca R&D Charnwood

Curated by ChEMBL


Assay Description
Inhibitory activity against cytosolic Phospholipase A2 (PLA2) by bilayer assay


J Med Chem 45: 1348-62 (2002)


Article DOI: 10.1021/jm011050x
BindingDB Entry DOI: 10.7270/Q2F76BVP
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (Human))
BDBM50056730
PNG
(CHEMBL3326948)
Show SMILES OC(=O)CCc1ccc2n(cc(CCc3ccccc3)c2c1)-c1ccccc1
Show InChI InChI=1S/C25H23NO2/c27-25(28)16-13-20-12-15-24-23(17-20)21(14-11-19-7-3-1-4-8-19)18-26(24)22-9-5-2-6-10-22/h1-10,12,15,17-18H,11,13-14,16H2,(H,27,28)
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n/an/a 75n/an/an/an/an/an/a



Asubio Pharma Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cPLA2alpha isolated from human U937 cell cytoplasm assessed as suppression of [14C]arachidonic acid release from L-alpha-1-palmitoyl-2-...


J Med Chem 57: 7244-62 (2014)


Article DOI: 10.1021/jm500494y
BindingDB Entry DOI: 10.7270/Q2F47QSP
More data for this
Ligand-Target Pair
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