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Compile Data Set for Download or QSAR

Found 228 hits Enz. Inhib. hit(s) with Target = 'interleukin-1 receptor-associated kinase 1'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM?mit=repeat?mit=repeat
Kd
nM
EC50/IC50
nM?mit=repeat?mit=repeat
koff
s-1
kon
M-1s-1
pHTemp
°C
Interleukin-1 receptor-associated kinase 1


(Homo sapiens (Human))
BDBM286212
PNG
(2,2-Dimethyl-propionic acid 2-[3-(6-oxo-3-pyridin-...)
Show SMILES CC(C)(C)C(=O)Oc1ccc2[nH]c(NC(=O)c3cccc(Cn4nc(ccc4=O)-c4cccnc4)c3)nc2c1
Show InChI InChI=1S/C29H26N6O4/c1-29(2,3)27(38)39-21-9-10-23-24(15-21)32-28(31-23)33-26(37)19-7-4-6-18(14-19)17-35-25(36)12-11-22(34-35)20-8-5-13-30-16-20/h4-16H,17H2,1-3H3,(H2,31,32,33,37)
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Assay Description
IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK-1 hydrolyses ATP and autophosphorylates.Measurement of IRA...


US Patent US9567320 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 1


(Homo sapiens (Human))
BDBM286217
PNG
(N-(1H-Benzoimidazol-2-yl)-3-(6-oxo-3-pyridin-3-yl-...)
Show SMILES O=C(Nc1nc2ccccc2[nH]1)c1cccc(Cn2nc(ccc2=O)-c2cccnc2)c1
Show InChI InChI=1S/C24H18N6O2/c31-22-11-10-19(18-7-4-12-25-14-18)29-30(22)15-16-5-3-6-17(13-16)23(32)28-24-26-20-8-1-2-9-21(20)27-24/h1-14H,15H2,(H2,26,27,28,32)
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Assay Description
IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK-1 hydrolyses ATP and autophosphorylates.Measurement of IRA...


US Patent US9567320 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 1


(Homo sapiens (Human))
BDBM286238
PNG
(N-(5-Hydroxymethyl-1H-benzoimidazol-2-yl)-3-(6-oxo...)
Show SMILES OCc1ccc2[nH]c(NC(=O)c3cccc(Cn4nc(ccc4=O)-c4cccnc4)c3)nc2c1
Show InChI InChI=1S/C25H20N6O3/c32-15-17-6-7-21-22(12-17)28-25(27-21)29-24(34)18-4-1-3-16(11-18)14-31-23(33)9-8-20(30-31)19-5-2-10-26-13-19/h1-13,32H,14-15H2,(H2,27,28,29,34)
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Assay Description
IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK-1 hydrolyses ATP and autophosphorylates.Measurement of IRA...


US Patent US9567320 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 1


(Homo sapiens (Human))
BDBM286247
PNG
(N-(5-Dimethylcarbamoylmethyl-1H-benzoimidazol-2-yl...)
Show SMILES CN(C)C(=O)Cc1ccc2[nH]c(NC(=O)c3cccc(Cn4nc(ccc4=O)-c4cccnc4)c3)nc2c1
Show InChI InChI=1S/C28H25N7O3/c1-34(2)26(37)15-18-8-9-23-24(14-18)31-28(30-23)32-27(38)20-6-3-5-19(13-20)17-35-25(36)11-10-22(33-35)21-7-4-12-29-16-21/h3-14,16H,15,17H2,1-2H3,(H2,30,31,32,38)
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Assay Description
IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK-1 hydrolyses ATP and autophosphorylates.Measurement of IRA...


US Patent US9567320 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 1


(Homo sapiens (Human))
BDBM286250
PNG
(N-(1H-Benzoimidazol-2-yl)-3-(6-oxo-3-pyrimidin-5-y...)
Show SMILES O=C(Nc1nc2ccccc2[nH]1)c1cccc(Cn2nc(ccc2=O)-c2cncnc2)c1
Show InChI InChI=1S/C23H17N7O2/c31-21-9-8-18(17-11-24-14-25-12-17)29-30(21)13-15-4-3-5-16(10-15)22(32)28-23-26-19-6-1-2-7-20(19)27-23/h1-12,14H,13H2,(H2,26,27,28,32)
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Assay Description
IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK-1 hydrolyses ATP and autophosphorylates.Measurement of IRA...


US Patent US9567320 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 1


(Homo sapiens (Human))
BDBM286259
PNG
(3-[3-(6-Amino-pyridin-3-yl)-6-oxo-6H-pyridazin-1-y...)
Show SMILES Nc1ccc(cn1)-c1ccc(=O)n(Cc2cccc(c2)C(=O)Nc2nc3ccccc3[nH]2)n1
Show InChI InChI=1S/C24H19N7O2/c25-21-10-8-17(13-26-21)18-9-11-22(32)31(30-18)14-15-4-3-5-16(12-15)23(33)29-24-27-19-6-1-2-7-20(19)28-24/h1-13H,14H2,(H2,25,26)(H2,27,28,29,33)
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Assay Description
IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK-1 hydrolyses ATP and autophosphorylates.Measurement of IRA...


US Patent US9567320 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 1


(Homo sapiens (Human))
BDBM286262
PNG
(N-(1H-benzo[d]imidazol-2-yl)-3-(2-cyano-5-(pyridin...)
Show SMILES Cc1cc(=O)n(Cc2cccc(c2)C(=O)Nc2nc3ccccc3[nH]2)nc1-c1cccnc1
Show InChI InChI=1S/C25H20N6O2/c1-16-12-22(32)31(30-23(16)19-8-5-11-26-14-19)15-17-6-4-7-18(13-17)24(33)29-25-27-20-9-2-3-10-21(20)28-25/h2-14H,15H2,1H3,(H2,27,28,29,33)
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Assay Description
IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK-1 hydrolyses ATP and autophosphorylates.Measurement of IRA...


US Patent US9567320 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 1


(Homo sapiens (Human))
BDBM286268
PNG
(N-(1H-benzo[d]imidazol-2-yl)-3-((3-(6-((dimethylam...)
Show SMILES CN(C)Cc1ccc(cn1)-c1ccc(=O)n(Cc2cccc(c2)C(=O)Nc2nc3ccccc3[nH]2)n1
Show InChI InChI=1S/C27H25N7O2/c1-33(2)17-21-11-10-20(15-28-21)22-12-13-25(35)34(32-22)16-18-6-5-7-19(14-18)26(36)31-27-29-23-8-3-4-9-24(23)30-27/h3-15H,16-17H2,1-2H3,(H2,29,30,31,36)
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Assay Description
IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK-1 hydrolyses ATP and autophosphorylates.Measurement of IRA...


US Patent US9567320 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 1


(Homo sapiens (Human))
BDBM286276
PNG
(N-(1H-benzo[d]imidazol-2-yl)-3-((3-(4-methylpyridi...)
Show SMILES Cc1ccncc1-c1ccc(=O)n(Cc2cccc(c2)C(=O)Nc2nc3ccccc3[nH]2)n1
Show InChI InChI=1S/C25H20N6O2/c1-16-11-12-26-14-19(16)20-9-10-23(32)31(30-20)15-17-5-4-6-18(13-17)24(33)29-25-27-21-7-2-3-8-22(21)28-25/h2-14H,15H2,1H3,(H2,27,28,29,33)
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Assay Description
IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK-1 hydrolyses ATP and autophosphorylates.Measurement of IRA...


US Patent US9567320 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 1


(Homo sapiens (Human))
BDBM286306
PNG
(N-(1H-benzo[d]imidazol-2-yl)-3-((3-(6-methylpyrida...)
Show SMILES Cc1cc(cnn1)-c1ccc(=O)n(Cc2cccc(c2)C(=O)Nc2nc3ccccc3[nH]2)n1
Show InChI InChI=1S/C24H19N7O2/c1-15-11-18(13-25-29-15)19-9-10-22(32)31(30-19)14-16-5-4-6-17(12-16)23(33)28-24-26-20-7-2-3-8-21(20)27-24/h2-13H,14H2,1H3,(H2,26,27,28,33)
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Assay Description
IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK-1 hydrolyses ATP and autophosphorylates.Measurement of IRA...


US Patent US9567320 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 1


(Homo sapiens (Human))
BDBM286321
PNG
(N-(5,6-dimethoxy-1H-benzo[d]imidazol-2-yl)-3-((6-o...)
Show SMILES COc1cc2nc(NC(=O)c3cccc(Cn4nc(ccc4=O)-c4cccnc4)c3)[nH]c2cc1OC
Show InChI InChI=1S/C26H22N6O4/c1-35-22-12-20-21(13-23(22)36-2)29-26(28-20)30-25(34)17-6-3-5-16(11-17)15-32-24(33)9-8-19(31-32)18-7-4-10-27-14-18/h3-14H,15H2,1-2H3,(H2,28,29,30,34)
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Assay Description
IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK-1 hydrolyses ATP and autophosphorylates.Measurement of IRA...


US Patent US9567320 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 1


(Homo sapiens (Human))
BDBM286325
PNG
(N-(5-methoxy-1H-benzo[d]imidazol-2-yl)-3-((6-oxo-3...)
Show SMILES COc1ccc2[nH]c(NC(=O)c3cccc(Cn4nc(ccc4=O)-c4cccnc4)c3)nc2c1
Show InChI InChI=1S/C25H20N6O3/c1-34-19-7-8-21-22(13-19)28-25(27-21)29-24(33)17-5-2-4-16(12-17)15-31-23(32)10-9-20(30-31)18-6-3-11-26-14-18/h2-14H,15H2,1H3,(H2,27,28,29,33)
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Assay Description
IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK-1 hydrolyses ATP and autophosphorylates.Measurement of IRA...


US Patent US9567320 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 1


(Homo sapiens (Human))
BDBM286326
PNG
(US9567320, Example 17**:)
Show SMILES OCc1cncc(c1)-c1ccc(=O)n(Cc2cccc(c2)C(=O)Nc2nc3ccccc3[nH]2)n1
Show InChI InChI=1S/C25H20N6O3/c32-15-17-11-19(13-26-12-17)20-8-9-23(33)31(30-20)14-16-4-3-5-18(10-16)24(34)29-25-27-21-6-1-2-7-22(21)28-25/h1-13,32H,14-15H2,(H2,27,28,29,34)
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Assay Description
IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK-1 hydrolyses ATP and autophosphorylates.Measurement of IRA...


US Patent US9567320 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 1 (IRAK1)


(Homo sapiens (Human))
BDBM318823
PNG
(US9624246, Compound 1)
Show SMILES Cn1cc2NC(=O)c3cccc(Cn4nc(OCCCNC(=O)c2n1)ccc4=O)c3
Show InChI InChI=1S/C20H20N6O4/c1-25-12-15-18(24-25)20(29)21-8-3-9-30-16-6-7-17(27)26(23-16)11-13-4-2-5-14(10-13)19(28)22-15/h2,4-7,10,12H,3,8-9,11H2,1H3,(H,21,29)(H,22,28)
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Assay Description
IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK1 hydrolyses ATP and autophosphorylates. Measurement of IRA...


US Patent US9624246 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 1 (IRAK1)


(Homo sapiens (Human))
BDBM318825
PNG
(US9624246, Compound 2)
Show SMILES Cn1cc2NC(=O)c3cccc(Cn4nc(ccc4=O)-c4cnn(CCNC(=O)c2n1)c4)c3
Show InChI InChI=1S/C22H20N8O3/c1-28-13-18-20(27-28)22(33)23-7-8-29-12-16(10-24-29)17-5-6-19(31)30(26-17)11-14-3-2-4-15(9-14)21(32)25-18/h2-6,9-10,12-13H,7-8,11H2,1H3,(H,23,33)(H,25,32)
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Assay Description
IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK1 hydrolyses ATP and autophosphorylates. Measurement of IRA...


US Patent US9624246 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 1 (IRAK1)


(Homo sapiens (Human))
BDBM318826
PNG
(US9624246, Compound 3)
Show SMILES Cn1cc2NC(=O)c3cccc(Cn4nc(ccc4=O)-c4cncc(CNC(=O)c2n1)c4)c3
Show InChI InChI=1S/C23H19N7O3/c1-29-13-19-21(28-29)23(33)25-10-15-8-17(11-24-9-15)18-5-6-20(31)30(27-18)12-14-3-2-4-16(7-14)22(32)26-19/h2-9,11,13H,10,12H2,1H3,(H,25,33)(H,26,32)
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Assay Description
IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK1 hydrolyses ATP and autophosphorylates. Measurement of IRA...


US Patent US9624246 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 1 (IRAK1)


(Homo sapiens (Human))
BDBM318827
PNG
(US9624246, Compound 4)
Show SMILES Cn1cc2NC(=O)c3cccc(Cn4nc(OCCNC(=O)c2n1)ccc4=O)c3
Show InChI InChI=1S/C19H18N6O4/c1-24-11-14-17(23-24)19(28)20-7-8-29-15-5-6-16(26)25(22-15)10-12-3-2-4-13(9-12)18(27)21-14/h2-6,9,11H,7-8,10H2,1H3,(H,20,28)(H,21,27)
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Assay Description
IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK1 hydrolyses ATP and autophosphorylates. Measurement of IRA...


US Patent US9624246 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 1 (IRAK1)


(Homo sapiens (Human))
BDBM318828
PNG
(US9624246, Compound 5)
Show SMILES Cn1cc2NC(=O)c3cccc(Cn4nc(OCCCCNC(=O)c2n1)ccc4=O)c3
Show InChI InChI=1S/C21H22N6O4/c1-26-13-16-19(25-26)21(30)22-9-2-3-10-31-17-7-8-18(28)27(24-17)12-14-5-4-6-15(11-14)20(29)23-16/h4-8,11,13H,2-3,9-10,12H2,1H3,(H,22,30)(H,23,29)
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Assay Description
IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK1 hydrolyses ATP and autophosphorylates. Measurement of IRA...


US Patent US9624246 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 1 (IRAK1)


(Homo sapiens (Human))
BDBM318829
PNG
(US9624246, Compound 6)
Show SMILES O=C1NCCCOc2ccc(=O)n(Cc3cccc(c3)C(=O)Nc3cn(nc13)C1CCOCC1)n2
Show InChI InChI=1S/C24H26N6O5/c31-21-6-5-20-27-30(21)14-16-3-1-4-17(13-16)23(32)26-19-15-29(18-7-11-34-12-8-18)28-22(19)24(33)25-9-2-10-35-20/h1,3-6,13,15,18H,2,7-12,14H2,(H,25,33)(H,26,32)
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Assay Description
IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK1 hydrolyses ATP and autophosphorylates. Measurement of IRA...


US Patent US9624246 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 1 (IRAK1)


(Homo sapiens (Human))
BDBM318830
PNG
(US9624246, Compound 7)
Show SMILES CC(C)(C)n1cc2NC(=O)c3cccc(Cn4nc(OCCCNC(=O)c2n1)ccc4=O)c3
Show InChI InChI=1S/C23H26N6O4/c1-23(2,3)29-14-17-20(27-29)22(32)24-10-5-11-33-18-8-9-19(30)28(26-18)13-15-6-4-7-16(12-15)21(31)25-17/h4,6-9,12,14H,5,10-11,13H2,1-3H3,(H,24,32)(H,25,31)
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Assay Description
IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK1 hydrolyses ATP and autophosphorylates. Measurement of IRA...


US Patent US9624246 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 1 (IRAK1)


(Homo sapiens (Human))
BDBM318831
PNG
(US9624246, Compound 8)
Show SMILES Cn1cc2NC(=O)c3cccc(Cn4nc(OCCCNC(=O)c2n1)ccc4=O)n3
Show InChI InChI=1S/C19H19N7O4/c1-25-11-14-17(24-25)19(29)20-8-3-9-30-15-6-7-16(27)26(23-15)10-12-4-2-5-13(21-12)18(28)22-14/h2,4-7,11H,3,8-10H2,1H3,(H,20,29)(H,22,28)
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Assay Description
IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK1 hydrolyses ATP and autophosphorylates. Measurement of IRA...


US Patent US9624246 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 1 (IRAK1)


(Homo sapiens (Human))
BDBM318832
PNG
(US9624246, Compound 9)
Show SMILES O=C1NCCCOc2ccc(=O)n(Cc3cccc(n3)C(=O)Nc3cn(nc13)C1CCOCC1)n2
Show InChI InChI=1S/C23H25N7O5/c31-20-6-5-19-27-30(20)13-15-3-1-4-17(25-15)22(32)26-18-14-29(16-7-11-34-12-8-16)28-21(18)23(33)24-9-2-10-35-19/h1,3-6,14,16H,2,7-13H2,(H,24,33)(H,26,32)
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Assay Description
IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK1 hydrolyses ATP and autophosphorylates. Measurement of IRA...


US Patent US9624246 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 1 (IRAK1)


(Homo sapiens (Human))
BDBM318833
PNG
(US9624246, Compound 10)
Show SMILES CC(C)(C)n1cc2NC(=O)c3cccc(Cn4nc(OCCCNC(=O)c2n1)ccc4=O)n3
Show InChI InChI=1S/C22H25N7O4/c1-22(2,3)29-13-16-19(27-29)21(32)23-10-5-11-33-17-8-9-18(30)28(26-17)12-14-6-4-7-15(24-14)20(31)25-16/h4,6-9,13H,5,10-12H2,1-3H3,(H,23,32)(H,25,31)
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Assay Description
IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK1 hydrolyses ATP and autophosphorylates. Measurement of IRA...


US Patent US9624246 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 1 (IRAK1)


(Homo sapiens (Human))
BDBM318834
PNG
(US9624246, Compound 11)
Show SMILES OC1CNC(=O)c2nn(cc2NC(=O)c2cccc(Cn3nc(OC1)ccc3=O)c2)C1CCOCC1
Show InChI InChI=1S/C24H26N6O6/c31-18-11-25-24(34)22-19(13-29(28-22)17-6-8-35-9-7-17)26-23(33)16-3-1-2-15(10-16)12-30-21(32)5-4-20(27-30)36-14-18/h1-5,10,13,17-18,31H,6-9,11-12,14H2,(H,25,34)(H,26,33)
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Assay Description
IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK1 hydrolyses ATP and autophosphorylates. Measurement of IRA...


US Patent US9624246 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 1 (IRAK1)


(Homo sapiens (Human))
BDBM318835
PNG
(US9624246, Compound 12)
Show SMILES Cn1cc2NC(=O)c3cccc(Cn4nc(OCC(O)CNC(=O)c2n1)ccc4=O)c3
Show InChI InChI=1S/C20H20N6O5/c1-25-10-15-18(24-25)20(30)21-8-14(27)11-31-16-5-6-17(28)26(23-16)9-12-3-2-4-13(7-12)19(29)22-15/h2-7,10,14,27H,8-9,11H2,1H3,(H,21,30)(H,22,29)
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Assay Description
IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK1 hydrolyses ATP and autophosphorylates. Measurement of IRA...


US Patent US9624246 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 1 (IRAK1)


(Homo sapiens (Human))
BDBM318836
PNG
(US9624246, Compound 13)
Show SMILES Cn1cc2NC(=O)c3cccc(Cn4nc(ccc4=O)-c4ccnc(CNC(=O)c2n1)c4)c3
Show InChI InChI=1S/C23H19N7O3/c1-29-13-19-21(28-29)23(33)25-11-17-10-15(7-8-24-17)18-5-6-20(31)30(27-18)12-14-3-2-4-16(9-14)22(32)26-19/h2-10,13H,11-12H2,1H3,(H,25,33)(H,26,32)
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Assay Description
IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK1 hydrolyses ATP and autophosphorylates. Measurement of IRA...


US Patent US9624246 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 1 (IRAK1)


(Homo sapiens (Human))
BDBM318837
PNG
(US9624246, Compound 14)
Show SMILES Cn1cc2NC(=O)c3cccc(Cn4nc(ccc4=O)-c4cccc(CCNC(=O)c2n1)c4)c3
Show InChI InChI=1S/C25H22N6O3/c1-30-15-21-23(29-30)25(34)26-11-10-16-4-2-6-18(12-16)20-8-9-22(32)31(28-20)14-17-5-3-7-19(13-17)24(33)27-21/h2-9,12-13,15H,10-11,14H2,1H3,(H,26,34)(H,27,33)
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Assay Description
IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK1 hydrolyses ATP and autophosphorylates. Measurement of IRA...


US Patent US9624246 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 1 (IRAK1)


(Homo sapiens (Human))
BDBM318838
PNG
(US9624246, Compound 15)
Show SMILES Cc1cc2NC(=O)c3cccc(Cn4nc(ccc4=O)-c4cccc(CCn2n1)c4)c3
Show InChI InChI=1S/C24H21N5O2/c1-16-12-22-25-24(31)20-7-3-5-18(14-20)15-29-23(30)9-8-21(27-29)19-6-2-4-17(13-19)10-11-28(22)26-16/h2-9,12-14H,10-11,15H2,1H3,(H,25,31)
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Assay Description
IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK1 hydrolyses ATP and autophosphorylates. Measurement of IRA...


US Patent US9624246 (2017)

More data for this
Ligand-Target Pair
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