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Compile Data Set for Download or QSAR

Found 1011 hits Enz. Inhib. hit(s) with Target = 'karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b


(Homo sapiens)
BDBM51981
PNG
(1-[4-[4-[(6-amino-2,5-dimethyl-3-imidazo[4,5-b]pyr...)
Show SMILES CC(=O)c1ccc(cc1)-c1ccc(Cn2c(C)nc3cc(N)c(C)nc23)cc1
Show InChI InChI=1S/C23H22N4O/c1-14-21(24)12-22-23(25-14)27(16(3)26-22)13-17-4-6-19(7-5-17)20-10-8-18(9-11-20)15(2)28/h4-12H,13,24H2,1-3H3
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n/an/an/an/a>5.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Counterscreen, FRET assay, HTS, YIC probe, Dose response, Assay Overview: This is a fluorescence resonance energy transfer (FRET)-based b...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b


(Homo sapiens)
BDBM47317
PNG
(1-[5-(2,3-dichlorophenyl)-2-furanyl]-N-[4-(4-morph...)
Show SMILES Clc1cccc(-c2ccc(\C=N\c3ccc(cc3)N3CCOCC3)o2)c1Cl
Show InChI InChI=1S/C21H18Cl2N2O2/c22-19-3-1-2-18(21(19)23)20-9-8-17(27-20)14-24-15-4-6-16(7-5-15)25-10-12-26-13-11-25/h1-9,14H,10-13H2/b24-14+
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n/an/an/an/a>5.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Counterscreen, FRET assay, HTS, YIC probe, Dose response, Assay Overview: This is a fluorescence resonance energy transfer (FRET)-based b...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b


(Homo sapiens)
BDBM74970
PNG
(1,3-benzothiazol-2-yl-[3-(2-morpholinoethyl)-2,4-d...)
Show SMILES C(CN1CNC(Nc2nc3ccccc3s2)=NC1)N1CCOCC1
Show InChI InChI=1S/C16H22N6OS/c1-2-4-14-13(3-1)19-16(24-14)20-15-17-11-22(12-18-15)6-5-21-7-9-23-10-8-21/h1-4H,5-12H2,(H2,17,18,19,20)
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Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Counterscreen, FRET assay, HTS, YIC probe, Dose response, Assay Overview: This is a fluorescence resonance energy transfer (FRET)-based b...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b


(Homo sapiens)
BDBM74971
PNG
(3-[2-(3,4-dimethoxyphenyl)ethyl]-2-methyl-4-quinaz...)
Show SMILES COc1ccc(CCn2c(C)nc3ccccc3c2=O)cc1OC
Show InChI InChI=1S/C19H20N2O3/c1-13-20-16-7-5-4-6-15(16)19(22)21(13)11-10-14-8-9-17(23-2)18(12-14)24-3/h4-9,12H,10-11H2,1-3H3
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Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Counterscreen, FRET assay, HTS, YIC probe, Dose response, Assay Overview: This is a fluorescence resonance energy transfer (FRET)-based b...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b


(Homo sapiens)
BDBM65365
PNG
((Z)-2-cyano-N-(4-methoxyphenyl)-3-(5-morpholin-4-y...)
Show SMILES COc1ccc(NC(=O)C(=C/c2ccc(o2)N2CCOCC2)\C#N)cc1
Show InChI InChI=1S/C19H19N3O4/c1-24-16-4-2-15(3-5-16)21-19(23)14(13-20)12-17-6-7-18(26-17)22-8-10-25-11-9-22/h2-7,12H,8-11H2,1H3,(H,21,23)/b14-12-
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n/an/an/an/a 4.69E+4n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Counterscreen, FRET assay, HTS, YIC probe, Dose response, Assay Overview: This is a fluorescence resonance energy transfer (FRET)-based b...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b


(Homo sapiens)
BDBM74972
PNG
((Z)-2-cyano-3-(5-morpholin-4-ylfuran-2-yl)-N-pheny...)
Show SMILES O=C(Nc1ccccc1)C(=C/c1ccc(o1)N1CCOCC1)\C#N
Show InChI InChI=1S/C18H17N3O3/c19-13-14(18(22)20-15-4-2-1-3-5-15)12-16-6-7-17(24-16)21-8-10-23-11-9-21/h1-7,12H,8-11H2,(H,20,22)/b14-12-
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n/an/an/an/a 1.49E+4n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Counterscreen, FRET assay, HTS, YIC probe, Dose response, Assay Overview: This is a fluorescence resonance energy transfer (FRET)-based b...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b


(Homo sapiens)
BDBM56675
PNG
(MLS000688874 | N-(2-phenylphenyl)-2-thiophenecarbo...)
Show SMILES O=C(Nc1ccccc1-c1ccccc1)c1cccs1
Show InChI InChI=1S/C17H13NOS/c19-17(16-11-6-12-20-16)18-15-10-5-4-9-14(15)13-7-2-1-3-8-13/h1-12H,(H,18,19)
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Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Counterscreen, FRET assay, HTS, YIC probe, Dose response, Assay Overview: This is a fluorescence resonance energy transfer (FRET)-based b...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b


(Homo sapiens)
BDBM74973
PNG
(2-amino-4-phenyl-1-pyrindan-3-carbonitrile | 2-ami...)
Show SMILES Nc1nc2CCCc2c(-c2ccccc2)c1C#N
Show InChI InChI=1S/C15H13N3/c16-9-12-14(10-5-2-1-3-6-10)11-7-4-8-13(11)18-15(12)17/h1-3,5-6H,4,7-8H2,(H2,17,18)
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n/an/an/an/a 9.81E+3n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Counterscreen, FRET assay, HTS, YIC probe, Dose response, Assay Overview: This is a fluorescence resonance energy transfer (FRET)-based b...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b


(Homo sapiens)
BDBM74974
PNG
(3-(4-chlorophenyl)imidazo[1,5-a]pyridine | MLS0007...)
Show SMILES Clc1ccc(cc1)-c1ncc2ccccn12
Show InChI InChI=1S/C13H9ClN2/c14-11-6-4-10(5-7-11)13-15-9-12-3-1-2-8-16(12)13/h1-9H
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Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Counterscreen, FRET assay, HTS, YIC probe, Dose response, Assay Overview: This is a fluorescence resonance energy transfer (FRET)-based b...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b


(Homo sapiens)
BDBM74975
PNG
(MLS000709333 | N-[(3,3-dimethyl-5-oxidanylidene-cy...)
Show SMILES CC1(C)CC(=O)C=C(C1)NNC(=O)C1CC11CCC1
Show InChI InChI=1S/C15H22N2O2/c1-14(2)7-10(6-11(18)8-14)16-17-13(19)12-9-15(12)4-3-5-15/h6,12,16H,3-5,7-9H2,1-2H3,(H,17,19)
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n/an/an/an/a>5.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Counterscreen, FRET assay, HTS, YIC probe, Dose response, Assay Overview: This is a fluorescence resonance energy transfer (FRET)-based b...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b


(Homo sapiens)
BDBM74976
PNG
(2-(4-amino-2,3-dimethyl-1-pyridin-1-iumyl)-1-(4-me...)
Show SMILES COc1ccc(cc1)C(=O)Cn1ccc(=[NH2+])c(C)c1C
Show InChI InChI=1S/C16H18N2O2/c1-11-12(2)18(9-8-15(11)17)10-16(19)13-4-6-14(20-3)7-5-13/h4-9,17H,10H2,1-3H3/p+1
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Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Counterscreen, FRET assay, HTS, YIC probe, Dose response, Assay Overview: This is a fluorescence resonance energy transfer (FRET)-based b...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b


(Homo sapiens)
BDBM74977
PNG
(MLS000709697 | N-[2-[(3-cyano-8-methyl-2-quinoliny...)
Show SMILES Cc1cccc2cc(C#N)c(NCCNC(=O)COc3ccccc3)nc12
Show InChI InChI=1S/C21H20N4O2/c1-15-6-5-7-16-12-17(13-22)21(25-20(15)16)24-11-10-23-19(26)14-27-18-8-3-2-4-9-18/h2-9,12H,10-11,14H2,1H3,(H,23,26)(H,24,25)
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n/an/an/an/a 2.70E+4n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Counterscreen, FRET assay, HTS, YIC probe, Dose response, Assay Overview: This is a fluorescence resonance energy transfer (FRET)-based b...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b


(Homo sapiens)
BDBM74978
PNG
(1,3-dihydrobenzo[e]benzimidazole-2-thione | CHEMBL...)
Show SMILES S=c1[nH]c2ccc3ccccc3c2[nH]1
Show InChI InChI=1S/C11H6N2S/c14-11-12-9-6-5-7-3-1-2-4-8(7)10(9)13-11/h1-6H
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n/an/an/an/a>5.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Counterscreen, FRET assay, HTS, YIC probe, Dose response, Assay Overview: This is a fluorescence resonance energy transfer (FRET)-based b...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b


(Homo sapiens)
BDBM74979
PNG
(2-(9-acridinylamino)ethanol | 2-(acridin-9-ylamino...)
Show SMILES OCCNc1c2ccccc2nc2ccccc12
Show InChI InChI=1S/C15H14N2O/c18-10-9-16-15-11-5-1-3-7-13(11)17-14-8-4-2-6-12(14)15/h1-8,18H,9-10H2,(H,16,17)
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n/an/an/an/a 4.89E+3n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Counterscreen, FRET assay, HTS, YIC probe, Dose response, Assay Overview: This is a fluorescence resonance energy transfer (FRET)-based b...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b


(Homo sapiens)
BDBM73643
PNG
(1-[1-(1-cyclopentyl-1,2,3,4-tetrazol-5-yl)propyl]p...)
Show SMILES CCC(N1CCC(CC1)C(N)=O)c1nnnn1C1CCCC1
Show InChI InChI=1S/C15H26N6O/c1-2-13(20-9-7-11(8-10-20)14(16)22)15-17-18-19-21(15)12-5-3-4-6-12/h11-13H,2-10H2,1H3,(H2,16,22)
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Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Counterscreen, FRET assay, HTS, YIC probe, Dose response, Assay Overview: This is a fluorescence resonance energy transfer (FRET)-based b...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b


(Homo sapiens)
BDBM74980
PNG
(3-[(E)-2-(4-chlorophenyl)ethenyl]imidazo[1,5-a]pyr...)
Show SMILES Clc1ccc(\C=C\c2ncc3ccccn23)cc1
Show InChI InChI=1S/C15H11ClN2/c16-13-7-4-12(5-8-13)6-9-15-17-11-14-3-1-2-10-18(14)15/h1-11H/b9-6+
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n/an/an/an/a 2.54E+3n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Counterscreen, FRET assay, HTS, YIC probe, Dose response, Assay Overview: This is a fluorescence resonance energy transfer (FRET)-based b...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b


(Homo sapiens)
BDBM74981
PNG
(MLS000856719 | N-cyclohexyl-2-(2-thenylamino)propi...)
Show SMILES CC(NCc1cccs1)C(=O)NC1CCCCC1
Show InChI InChI=1S/C14H22N2OS/c1-11(15-10-13-8-5-9-18-13)14(17)16-12-6-3-2-4-7-12/h5,8-9,11-12,15H,2-4,6-7,10H2,1H3,(H,16,17)
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Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Counterscreen, FRET assay, HTS, YIC probe, Dose response, Assay Overview: This is a fluorescence resonance energy transfer (FRET)-based b...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b


(Homo sapiens)
BDBM74982
PNG
(4-(3-hydroxyphenyl)-1-(2-oxolanylmethyl)-4H-pyridi...)
Show SMILES COC(=O)C1=CN(CC2CCCO2)C=C(C1c1cccc(O)c1)C(=O)OC
Show InChI InChI=1S/C20H23NO6/c1-25-19(23)16-11-21(10-15-7-4-8-27-15)12-17(20(24)26-2)18(16)13-5-3-6-14(22)9-13/h3,5-6,9,11-12,15,18,22H,4,7-8,10H2,1-2H3
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n/an/an/an/a 1.98E+4n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Counterscreen, FRET assay, HTS, YIC probe, Dose response, Assay Overview: This is a fluorescence resonance energy transfer (FRET)-based b...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b


(Homo sapiens)
BDBM53973
PNG
(2-[3-[(E)-[3-[2-(1-azepanyl)-2-oxoethyl]-2,4-dioxo...)
Show SMILES OC(=O)Cn1cc(\C=C2\SC(=O)N(CC(=O)N3CCCCCC3)C2=O)c2ccccc12
Show InChI InChI=1S/C22H23N3O5S/c26-19(23-9-5-1-2-6-10-23)13-25-21(29)18(31-22(25)30)11-15-12-24(14-20(27)28)17-8-4-3-7-16(15)17/h3-4,7-8,11-12H,1-2,5-6,9-10,13-14H2,(H,27,28)/b18-11+
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n/an/an/an/a>5.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Counterscreen, FRET assay, HTS, YIC probe, Dose response, Assay Overview: This is a fluorescence resonance energy transfer (FRET)-based b...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b


(Homo sapiens)
BDBM74983
PNG
(1-(1,5-dimethylpyrazol-4-yl)sulfonylnipecotic acid...)
Show SMILES Cc1c(cnn1C)S(=O)(=O)N1CCCC(C1)C(O)=O
Show InChI InChI=1S/C11H17N3O4S/c1-8-10(6-12-13(8)2)19(17,18)14-5-3-4-9(7-14)11(15)16/h6,9H,3-5,7H2,1-2H3,(H,15,16)
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Broad Institute

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Assay Description
Keywords: Counterscreen, FRET assay, HTS, YIC probe, Dose response, Assay Overview: This is a fluorescence resonance energy transfer (FRET)-based b...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b


(Homo sapiens)
BDBM74984
PNG
(3-(dimethylsulfamoyl)-4-methoxy-benzoic acid | 3-(...)
Show SMILES COc1ccc(cc1S(=O)(=O)N(C)C)C(O)=O
Show InChI InChI=1S/C10H13NO5S/c1-11(2)17(14,15)9-6-7(10(12)13)4-5-8(9)16-3/h4-6H,1-3H3,(H,12,13)
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Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Counterscreen, FRET assay, HTS, YIC probe, Dose response, Assay Overview: This is a fluorescence resonance energy transfer (FRET)-based b...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b


(Homo sapiens)
BDBM74985
PNG
(2-[(2-phenyl-4-quinazolinyl)amino]ethanol;hydrochl...)
Show SMILES OCCNc1nc(nc2ccccc12)-c1ccccc1
Show InChI InChI=1S/C16H15N3O/c20-11-10-17-16-13-8-4-5-9-14(13)18-15(19-16)12-6-2-1-3-7-12/h1-9,20H,10-11H2,(H,17,18,19)
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Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Counterscreen, FRET assay, HTS, YIC probe, Dose response, Assay Overview: This is a fluorescence resonance energy transfer (FRET)-based b...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b


(Homo sapiens)
BDBM74986
PNG
(2-[2-[cyclopentyl(propanoyl)amino]ethanoylamino]-4...)
Show SMILES CCC(=O)N(CC(=O)Nc1sc(C)c(C)c1C(N)=O)C1CCCC1
Show InChI InChI=1S/C17H25N3O3S/c1-4-14(22)20(12-7-5-6-8-12)9-13(21)19-17-15(16(18)23)10(2)11(3)24-17/h12H,4-9H2,1-3H3,(H2,18,23)(H,19,21)
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Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Counterscreen, FRET assay, HTS, YIC probe, Dose response, Assay Overview: This is a fluorescence resonance energy transfer (FRET)-based b...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b


(Homo sapiens)
BDBM74987
PNG
(MLS000729542 | N-(12-keto-7,8,9,10-tetrahydro-6H-a...)
Show SMILES O=c1n2CCCCCc2nc2ccc(NC(=S)N3CCC(CC3)N3CCCCC3)cc12
Show InChI InChI=1S/C24H33N5OS/c30-23-20-17-18(8-9-21(20)26-22-7-3-1-6-14-29(22)23)25-24(31)28-15-10-19(11-16-28)27-12-4-2-5-13-27/h8-9,17,19H,1-7,10-16H2,(H,25,31)
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Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Counterscreen, FRET assay, HTS, YIC probe, Dose response, Assay Overview: This is a fluorescence resonance energy transfer (FRET)-based b...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b


(Homo sapiens)
BDBM74988
PNG
(1-[1-allyl-4-(4-benzhydrylpiperazin-1-yl)-6-methyl...)
Show SMILES CC(=O)c1c(C)n(CC=C)c(=S)nc1N1CCN(CC1)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C27H30N4OS/c1-4-15-31-20(2)24(21(3)32)26(28-27(31)33)30-18-16-29(17-19-30)25(22-11-7-5-8-12-22)23-13-9-6-10-14-23/h4-14,25H,1,15-19H2,2-3H3
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Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Counterscreen, FRET assay, HTS, YIC probe, Dose response, Assay Overview: This is a fluorescence resonance energy transfer (FRET)-based b...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b


(Homo sapiens)
BDBM74989
PNG
(2-(4-keto-5,6-dimethyl-thieno[2,3-d]pyrimidin-3-yl...)
Show SMILES Cc1sc2ncn(CC(=O)NCCCC(=O)N3CCN(Cc4ccc5OCOc5c4)CC3)c(=O)c2c1C
Show InChI InChI=1S/C26H31N5O5S/c1-17-18(2)37-25-24(17)26(34)31(15-28-25)14-22(32)27-7-3-4-23(33)30-10-8-29(9-11-30)13-19-5-6-20-21(12-19)36-16-35-20/h5-6,12,15H,3-4,7-11,13-14,16H2,1-2H3,(H,27,32)
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Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Counterscreen, FRET assay, HTS, YIC probe, Dose response, Assay Overview: This is a fluorescence resonance energy transfer (FRET)-based b...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b


(Homo sapiens)
BDBM74990
PNG
(4-chloranyl-N-ethyl-N-(2-methylphenyl)-2-nitro-ben...)
Show SMILES CCN(C(=O)c1ccc(Cl)cc1[N+]([O-])=O)c1ccccc1C
Show InChI InChI=1S/C16H15ClN2O3/c1-3-18(14-7-5-4-6-11(14)2)16(20)13-9-8-12(17)10-15(13)19(21)22/h4-10H,3H2,1-2H3
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Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Counterscreen, FRET assay, HTS, YIC probe, Dose response, Assay Overview: This is a fluorescence resonance energy transfer (FRET)-based b...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b


(Homo sapiens)
BDBM74991
PNG
((2,6-difluoropyrimidin-4-yl)-methyl-amine | 2,6-bi...)
Show SMILES CNc1cc(F)nc(F)n1
Show InChI InChI=1S/C5H5F2N3/c1-8-4-2-3(6)9-5(7)10-4/h2H,1H3,(H,8,9,10)
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n/an/an/an/a 2.17E+4n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Counterscreen, FRET assay, HTS, YIC probe, Dose response, Assay Overview: This is a fluorescence resonance energy transfer (FRET)-based b...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b


(Homo sapiens)
BDBM74992
PNG
(2-(3-nitrophenyl)-2,3-dihydro-1,3-benzoxazin-4-one...)
Show SMILES [O-][N+](=O)c1cccc(c1)C1NC(=O)c2ccccc2O1
Show InChI InChI=1S/C14H10N2O4/c17-13-11-6-1-2-7-12(11)20-14(15-13)9-4-3-5-10(8-9)16(18)19/h1-8,14H,(H,15,17)
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Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Counterscreen, FRET assay, HTS, YIC probe, Dose response, Assay Overview: This is a fluorescence resonance energy transfer (FRET)-based b...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b


(Homo sapiens)
BDBM74993
PNG
(MLS000728709 | N-[4-(2-thenoylamino)furazan-3-yl]t...)
Show SMILES O=C(Nc1nonc1NC(=O)c1cccs1)c1cccs1
Show InChI InChI=1S/C12H8N4O3S2/c17-11(7-3-1-5-20-7)13-9-10(16-19-15-9)14-12(18)8-4-2-6-21-8/h1-6H,(H,13,15,17)(H,14,16,18)
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Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Counterscreen, FRET assay, HTS, YIC probe, Dose response, Assay Overview: This is a fluorescence resonance energy transfer (FRET)-based b...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b


(Homo sapiens)
BDBM74994
PNG
((2-esyl-4-tosyl-thiazol-5-yl)-(2-pyridylmethyl)ami...)
Show SMILES CCS(=O)(=O)c1nc(c(NCc2ccccn2)s1)S(=O)(=O)c1ccc(C)cc1
Show InChI InChI=1S/C18H19N3O4S3/c1-3-27(22,23)18-21-17(28(24,25)15-9-7-13(2)8-10-15)16(26-18)20-12-14-6-4-5-11-19-14/h4-11,20H,3,12H2,1-2H3
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Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Counterscreen, FRET assay, HTS, YIC probe, Dose response, Assay Overview: This is a fluorescence resonance energy transfer (FRET)-based b...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b


(Homo sapiens)
BDBM74995
PNG
(5-(3-nitrophenyl)-3-propyl-1,2,4-oxadiazole | MLS0...)
Show SMILES CCCc1noc(n1)-c1cccc(c1)[N+]([O-])=O
Show InChI InChI=1S/C11H11N3O3/c1-2-4-10-12-11(17-13-10)8-5-3-6-9(7-8)14(15)16/h3,5-7H,2,4H2,1H3
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Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Counterscreen, FRET assay, HTS, YIC probe, Dose response, Assay Overview: This is a fluorescence resonance energy transfer (FRET)-based b...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b


(Homo sapiens)
BDBM47499
PNG
(1-[(Z)-2-(4-chlorophenyl)ethenyl]-9H-pyrido[3,4-b]...)
Show SMILES Clc1ccc(\C=C/c2nccc3c4ccccc4[nH]c23)cc1
Show InChI InChI=1S/C19H13ClN2/c20-14-8-5-13(6-9-14)7-10-18-19-16(11-12-21-18)15-3-1-2-4-17(15)22-19/h1-12,22H/b10-7-
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n/an/an/an/a 8.61E+3n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Counterscreen, FRET assay, HTS, YIC probe, Dose response, Assay Overview: This is a fluorescence resonance energy transfer (FRET)-based b...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b


(Homo sapiens)
BDBM74996
PNG
(1-{[(2,6-dimethylphenyl)amino]carbonyl}-3-oxo-2-(t...)
Show SMILES Cc1cccc(C)c1NC(=O)C1N(Cc2cccs2)C(=O)C[n+]2ccccc12
Show InChI InChI=1S/C22H21N3O2S/c1-15-7-5-8-16(2)20(15)23-22(27)21-18-10-3-4-11-24(18)14-19(26)25(21)13-17-9-6-12-28-17/h3-12,21H,13-14H2,1-2H3/p+1
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Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Counterscreen, FRET assay, HTS, YIC probe, Dose response, Assay Overview: This is a fluorescence resonance energy transfer (FRET)-based b...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b


(Homo sapiens)
BDBM74997
PNG
(9-chloranyl-N-cyclopropyl-5,6,7,8-tetrahydroacridi...)
Show SMILES Clc1c2CCCCc2nc2cc(ccc12)C(=O)NC1CC1
Show InChI InChI=1S/C17H17ClN2O/c18-16-12-3-1-2-4-14(12)20-15-9-10(5-8-13(15)16)17(21)19-11-6-7-11/h5,8-9,11H,1-4,6-7H2,(H,19,21)
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Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Counterscreen, FRET assay, HTS, YIC probe, Dose response, Assay Overview: This is a fluorescence resonance energy transfer (FRET)-based b...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b


(Homo sapiens)
BDBM74998
PNG
(1-(5-bromanylthiophen-2-yl)sulfonyl-N-[2-(4-sulfam...)
Show SMILES NS(=O)(=O)c1ccc(CCNC(=O)C2CCN(CC2)S(=O)(=O)c2ccc(Br)s2)cc1
Show InChI InChI=1S/C18H22BrN3O5S3/c19-16-5-6-17(28-16)30(26,27)22-11-8-14(9-12-22)18(23)21-10-7-13-1-3-15(4-2-13)29(20,24)25/h1-6,14H,7-12H2,(H,21,23)(H2,20,24,25)
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Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Counterscreen, FRET assay, HTS, YIC probe, Dose response, Assay Overview: This is a fluorescence resonance energy transfer (FRET)-based b...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b


(Homo sapiens)
BDBM74999
PNG
(3-(3-methoxyphenyl)-N-(5-methyl-1,2-oxazol-3-yl)-4...)
Show SMILES COc1cccc(c1)C1=NOC(C1)C(=O)Nc1cc(C)on1
Show InChI InChI=1S/C15H15N3O4/c1-9-6-14(18-21-9)16-15(19)13-8-12(17-22-13)10-4-3-5-11(7-10)20-2/h3-7,13H,8H2,1-2H3,(H,16,18,19)
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Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Counterscreen, FRET assay, HTS, YIC probe, Dose response, Assay Overview: This is a fluorescence resonance energy transfer (FRET)-based b...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b


(Homo sapiens)
BDBM75000
PNG
(2-methoxyethyl-[5-methyl-2-(p-tolyl)pyrazolo[1,5-a...)
Show SMILES COCCNc1cc(C)nc2cc(nn12)-c1ccc(C)cc1
Show InChI InChI=1S/C17H20N4O/c1-12-4-6-14(7-5-12)15-11-17-19-13(2)10-16(21(17)20-15)18-8-9-22-3/h4-7,10-11,18H,8-9H2,1-3H3
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n/an/an/an/a 3.77E+3n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Counterscreen, FRET assay, HTS, YIC probe, Dose response, Assay Overview: This is a fluorescence resonance energy transfer (FRET)-based b...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b


(Homo sapiens)
BDBM75040
PNG
(MLS000673318 | N'-{(1E)-[3-hydroxy-5-(hydroxym...)
Show SMILES COc1ccc(cc1)C(=O)NNCc1c(O)c(C)ncc1C=O
Show InChI InChI=1S/C16H17N3O4/c1-10-15(21)14(12(9-20)7-17-10)8-18-19-16(22)11-3-5-13(23-2)6-4-11/h3-7,9,18,21H,8H2,1-2H3,(H,19,22)
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n/an/an/an/a 1.52E+3n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Counterscreen, FRET assay, HTS, YIC probe, Dose response, Assay Overview: This is a fluorescence resonance energy transfer (FRET)-based b...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b


(Homo sapiens)
BDBM75041
PNG
(1-(3,4-dimethoxyphenyl)-3-benzo[f]quinolinecarboxy...)
Show SMILES COc1ccc(cc1OC)-c1cc(nc2ccc3ccccc3c12)C(O)=O
Show InChI InChI=1S/C22H17NO4/c1-26-19-10-8-14(11-20(19)27-2)16-12-18(22(24)25)23-17-9-7-13-5-3-4-6-15(13)21(16)17/h3-12H,1-2H3,(H,24,25)
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Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Counterscreen, FRET assay, HTS, YIC probe, Dose response, Assay Overview: This is a fluorescence resonance energy transfer (FRET)-based b...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b


(Homo sapiens)
BDBM75042
PNG
((6Z)-5-imino-6-(1H-indol-3-ylmethylene)-3-(methyls...)
Show SMILES CS(=O)(=O)c1nsc2nc(=O)c(\C=C3/C=Nc4ccccc34)c(N)n12
Show InChI InChI=1S/C15H11N5O3S2/c1-25(22,23)15-19-24-14-18-13(21)10(12(16)20(14)15)6-8-7-17-11-5-3-2-4-9(8)11/h2-7H,16H2,1H3/b8-6+
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n/an/an/an/a 2.01E+4n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Counterscreen, FRET assay, HTS, YIC probe, Dose response, Assay Overview: This is a fluorescence resonance energy transfer (FRET)-based b...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b


(Homo sapiens)
BDBM54019
PNG
((6Z)-5-imino-6-(1H-indol-3-ylmethylene)-3-(isoprop...)
Show SMILES CC(C)S(=O)(=O)c1nsc2nc(=O)c(\C=C3/C=Nc4ccccc34)c(N)n12
Show InChI InChI=1S/C17H15N5O3S2/c1-9(2)27(24,25)17-21-26-16-20-15(23)12(14(18)22(16)17)7-10-8-19-13-6-4-3-5-11(10)13/h3-9H,18H2,1-2H3/b10-7+
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n/an/an/an/a 9.72E+3n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Counterscreen, FRET assay, HTS, YIC probe, Dose response, Assay Overview: This is a fluorescence resonance energy transfer (FRET)-based b...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b


(Homo sapiens)
BDBM54022
PNG
(1-(5-thiophen-2-yl-2-thiophenyl)ethanone | 1-(5-th...)
Show SMILES CC(=O)c1ccc(s1)-c1cccs1
Show InChI InChI=1S/C10H8OS2/c1-7(11)8-4-5-10(13-8)9-3-2-6-12-9/h2-6H,1H3
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n/an/an/an/a 2.89E+4n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Counterscreen, FRET assay, HTS, YIC probe, Dose response, Assay Overview: This is a fluorescence resonance energy transfer (FRET)-based b...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b


(Homo sapiens)
BDBM75043
PNG
(4-(4-tert-butylbenzoyl)-N-(dimethylaminomethylene)...)
Show SMILES CN(C)\C=N\C(=O)c1cc(c[nH]1)C(=O)c1ccc(cc1)C(C)(C)C
Show InChI InChI=1S/C19H23N3O2/c1-19(2,3)15-8-6-13(7-9-15)17(23)14-10-16(20-11-14)18(24)21-12-22(4)5/h6-12,20H,1-5H3/b21-12+
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n/an/an/an/a>5.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Counterscreen, FRET assay, HTS, YIC probe, Dose response, Assay Overview: This is a fluorescence resonance energy transfer (FRET)-based b...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b


(Homo sapiens)
BDBM75044
PNG
(2-methyl-5-[[(4-nitrophenyl)-oxomethyl]amino]-6-ox...)
Show SMILES COC(=O)c1cc(NC(=O)c2ccc(cc2)[N+]([O-])=O)c(=O)oc1C
Show InChI InChI=1S/C15H12N2O7/c1-8-11(14(19)23-2)7-12(15(20)24-8)16-13(18)9-3-5-10(6-4-9)17(21)22/h3-7H,1-2H3,(H,16,18)
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n/an/an/an/a>5.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Counterscreen, FRET assay, HTS, YIC probe, Dose response, Assay Overview: This is a fluorescence resonance energy transfer (FRET)-based b...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b


(Homo sapiens)
BDBM75045
PNG
(1-keto-2-(3-pyridylmethyl)isoquinoline-4-carboxyli...)
Show SMILES OC(=O)c1cn(Cc2cccnc2)c(=O)c2ccccc12
Show InChI InChI=1S/C16H12N2O3/c19-15-13-6-2-1-5-12(13)14(16(20)21)10-18(15)9-11-4-3-7-17-8-11/h1-8,10H,9H2,(H,20,21)
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n/an/an/an/a>5.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Counterscreen, FRET assay, HTS, YIC probe, Dose response, Assay Overview: This is a fluorescence resonance energy transfer (FRET)-based b...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b


(Homo sapiens)
BDBM34946
PNG
((E)-4-keto-4-[(3-keto-4H-1,4-benzoxazin-6-yl)amino...)
Show SMILES OC(=O)\C=C\C(=O)Nc1ccc2OCC(=O)Nc2c1
Show InChI InChI=1S/C12H10N2O5/c15-10(3-4-12(17)18)13-7-1-2-9-8(5-7)14-11(16)6-19-9/h1-5H,6H2,(H,13,15)(H,14,16)(H,17,18)/b4-3+
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n/an/an/an/a>5.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Counterscreen, FRET assay, HTS, YIC probe, Dose response, Assay Overview: This is a fluorescence resonance energy transfer (FRET)-based b...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b


(Homo sapiens)
BDBM75046
PNG
(MLS001003514 | N-(2-methoxyphenyl)-2-methyl-3-quin...)
Show SMILES COc1ccccc1NC(=O)c1cc2ccccc2nc1C
Show InChI InChI=1S/C18H16N2O2/c1-12-14(11-13-7-3-4-8-15(13)19-12)18(21)20-16-9-5-6-10-17(16)22-2/h3-11H,1-2H3,(H,20,21)
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n/an/an/an/a>5.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Counterscreen, FRET assay, HTS, YIC probe, Dose response, Assay Overview: This is a fluorescence resonance energy transfer (FRET)-based b...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b


(Homo sapiens)
BDBM75047
PNG
(2-(3-thienyl)acetic acid [2-(2,4-dimethylanilino)-...)
Show SMILES Cc1ccc(NC(=O)COC(=O)Cc2ccsc2)c(C)c1
Show InChI InChI=1S/C16H17NO3S/c1-11-3-4-14(12(2)7-11)17-15(18)9-20-16(19)8-13-5-6-21-10-13/h3-7,10H,8-9H2,1-2H3,(H,17,18)
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n/an/an/an/a>5.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Counterscreen, FRET assay, HTS, YIC probe, Dose response, Assay Overview: This is a fluorescence resonance energy transfer (FRET)-based b...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b


(Homo sapiens)
BDBM63660
PNG
(8-(1,3-dithiolan-2-ylidene)-4-(4-methoxyphenyl)-1,...)
Show SMILES COc1ccc(cc1)C1NC(=S)N=C2C1CCCC2=C1SCCS1
Show InChI InChI=1S/C18H20N2OS3/c1-21-12-7-5-11(6-8-12)15-13-3-2-4-14(17-23-9-10-24-17)16(13)20-18(22)19-15/h5-8,13,15H,2-4,9-10H2,1H3,(H,19,22)
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n/an/an/an/a>5.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Counterscreen, FRET assay, HTS, YIC probe, Dose response, Assay Overview: This is a fluorescence resonance energy transfer (FRET)-based b...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
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