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Compile Data Set for Download or QSAR

Found 380 hits Enz. Inhib. hit(s) with Target = 'neuropeptides B/W receptor 1' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
neuropeptides B/W receptor 1


(Homo sapiens)
BDBM50013388
PNG
(6-Ethyl-3-(1-hydroxy-cyclopropylmethyl)-11,11-dime...)
Show SMILES CCC12CCN(CC3(O)CC3)C(Cc3ccc(O)cc13)C2(C)C
Show InChI InChI=1S/C20H29NO2/c1-4-20-9-10-21(13-19(23)7-8-19)17(18(20,2)3)11-14-5-6-15(22)12-16(14)20/h5-6,12,17,22-23H,4,7-11,13H2,1-3H3
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6n/an/an/an/an/an/an/an/a



Addiction Research Foundation

Curated by PDSP Ki Database




Genomics 28: 84-91 (1995)

More data for this
Ligand-Target Pair
neuropeptides B/W receptor 1


(Homo sapiens)
BDBM50247803
PNG
(Beta-Funeltrexamine | CHEMBL473136 | beta-funaltre...)
Show SMILES COC(=O)\C=C\C(=O)N[C@@H]1CC[C@@]2(O)[C@H]3Cc4ccc(O)c5O[C@@H]1[C@]2(CCN3CC1CC1)c45
Show InChI InChI=1S/C25H30N2O6/c1-32-20(30)7-6-19(29)26-16-8-9-25(31)18-12-15-4-5-17(28)22-21(15)24(25,23(16)33-22)10-11-27(18)13-14-2-3-14/h4-7,14,16,18,23,28,31H,2-3,8-13H2,1H3,(H,26,29)/b7-6+/t16-,18-,23+,24+,25-/m1/s1
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PubMed
93n/an/an/an/an/an/an/an/a



Addiction Research Foundation

Curated by PDSP Ki Database




Genomics 28: 84-91 (1995)

More data for this
Ligand-Target Pair
neuropeptides B/W receptor 1


(Homo sapiens)
BDBM50166066
PNG
(CHEMBL362991 | H-Tyr-Pro-Phe-Pro-NH2 | MORPHICEPTI...)
Show SMILES N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(N)=O
Show InChI InChI=1S/C28H35N5O5/c29-21(16-19-10-12-20(34)13-11-19)27(37)33-15-5-9-24(33)26(36)31-22(17-18-6-2-1-3-7-18)28(38)32-14-4-8-23(32)25(30)35/h1-3,6-7,10-13,21-24,34H,4-5,8-9,14-17,29H2,(H2,30,35)(H,31,36)/t21-,22-,23-,24-/m0/s1
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145n/an/an/an/an/an/an/an/a



Addiction Research Foundation

Curated by PDSP Ki Database




Genomics 28: 84-91 (1995)

More data for this
Ligand-Target Pair
neuropeptides B/W receptor 1


(Homo sapiens)
BDBM50169774
PNG
(2-(3,4-Dichloro-phenyl)-N-methyl-N-(2-pyrrolidin-1...)
Show SMILES CN(C1CCCC[C@H]1N1CCCC1)C(=O)Cc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C19H26Cl2N2O/c1-22(19(24)13-14-8-9-15(20)16(21)12-14)17-6-2-3-7-18(17)23-10-4-5-11-23/h8-9,12,17-18H,2-7,10-11,13H2,1H3/t17?,18-/m1/s1
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610n/an/an/an/an/an/an/an/a



Addiction Research Foundation

Curated by PDSP Ki Database




Genomics 28: 84-91 (1995)

More data for this
Ligand-Target Pair
neuropeptides B/W receptor 1


(Homo sapiens)
BDBM21864
PNG
((21R)-22-(cyclopropylmethyl)-14-oxa-11,22-diazahep...)
Show SMILES Oc1ccc2C[C@H]3N(CC4CC4)CCC45C(Oc1c24)c1[nH]c2ccccc2c1CC35O
Show InChI InChI=1S/C26H26N2O3/c29-19-8-7-15-11-20-26(30)12-17-16-3-1-2-4-18(16)27-22(17)24-25(26,21(15)23(19)31-24)9-10-28(20)13-14-5-6-14/h1-4,7-8,14,20,24,27,29-30H,5-6,9-13H2/t20-,24?,25?,26?/m0/s1
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1.23E+3n/an/an/an/an/an/an/an/a



Addiction Research Foundation

Curated by PDSP Ki Database




Genomics 28: 84-91 (1995)

More data for this
Ligand-Target Pair
neuropeptides B/W receptor 1


(Homo sapiens)
BDBM81935
PNG
(CAS_105618-26-6 | NSC_3034416 | Nor-BNI)
Show SMILES Oc1ccc2CC(C3CC3)N3CCC45C(Oc1c24)c1[nH]c2C4Oc6c7c(CC(C8CC8)N8CCC47C(O)(C8)Cc2c1CC5(O)C3)ccc6O
Show InChI InChI=1S/C40H43N3O6/c44-27-7-5-21-13-25(19-1-2-19)42-11-9-39-29(21)33(27)48-35(39)31-23(15-37(39,46)17-42)24-16-38(47)18-43-12-10-40(38)30-22(14-26(43)20-3-4-20)6-8-28(45)34(30)49-36(40)32(24)41-31/h5-8,19-20,25-26,35-36,41,44-47H,1-4,9-18H2
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1.34E+3n/an/an/an/an/an/an/an/a



Addiction Research Foundation

Curated by PDSP Ki Database




Genomics 28: 84-91 (1995)

More data for this
Ligand-Target Pair
neuropeptides B/W receptor 1


(Homo sapiens)
BDBM82274
PNG
(Beta-Endorphin (6-31))
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(O)=O
Show InChI InChI=1S/C131H218N34O40/c1-16-68(9)103(127(200)151-82(38-25-30-54-136)112(185)155-90(60-96(138)173)116(189)142-70(11)107(180)152-88(59-76-40-42-77(171)43-41-76)119(192)147-79(35-22-27-51-133)110(183)145-78(34-21-26-50-132)109(182)141-62-98(175)144-85(131(204)205)46-49-100(178)179)162-128(201)104(69(10)17-2)161-108(181)71(12)143-117(190)91(61-97(139)174)154-111(184)80(36-23-28-52-134)148-120(193)89(58-75-32-19-18-20-33-75)153-118(191)86(56-65(3)4)157-129(202)105(73(14)169)163-126(199)102(67(7)8)160-121(194)87(57-66(5)6)156-124(197)94-39-31-55-165(94)130(203)106(74(15)170)164-115(188)83(44-47-95(137)172)149-122(195)92(63-166)158-113(186)81(37-24-29-53-135)146-114(187)84(45-48-99(176)177)150-123(196)93(64-167)159-125(198)101(140)72(13)168/h18-20,32-33,40-43,65-74,78-94,101-106,166-171H,16-17,21-31,34-39,44-64,132-136,140H2,1-15H3,(H2,137,172)(H2,138,173)(H2,139,174)(H,141,182)(H,142,189)(H,143,190)(H,144,175)(H,145,183)(H,146,187)(H,147,192)(H,148,193)(H,149,195)(H,150,196)(H,151,200)(H,152,180)(H,153,191)(H,154,184)(H,155,185)(H,156,197)(H,157,202)(H,158,186)(H,159,198)(H,160,194)(H,161,181)(H,162,201)(H,163,199)(H,164,188)(H,176,177)(H,178,179)(H,204,205)/t68-,69-,70-,71-,72+,73+,74+,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,101-,102-,103-,104-,105-,106-/m0/s1
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2.40E+3n/an/an/an/an/an/an/an/a



Addiction Research Foundation

Curated by PDSP Ki Database




Genomics 28: 84-91 (1995)

More data for this
Ligand-Target Pair
neuropeptides B/W receptor 1


(Homo sapiens)
BDBM50000788
PNG
((morphine)4-methyl-(1S,5R,13R,14S,17R)-12-oxa-4-az...)
Show SMILES Oc1ccc2C[C@H]3N(CC=C)CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O
Show InChI InChI=1S/C19H21NO4/c1-2-8-20-9-7-18-15-11-3-4-12(21)16(15)24-17(18)13(22)5-6-19(18,23)14(20)10-11/h2-4,14,17,21,23H,1,5-10H2/t14-,17+,18+,19-/m1/s1
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3.00E+3n/an/an/an/an/an/an/an/a



Addiction Research Foundation

Curated by PDSP Ki Database




Genomics 28: 84-91 (1995)

More data for this
Ligand-Target Pair
neuropeptides B/W receptor 1


(Homo sapiens)
BDBM21015
PNG
((2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl...)
Show SMILES C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N(C)[C@@H](Cc1ccccc1)C(=O)NCCO
Show InChI InChI=1S/C26H35N5O6/c1-17(30-25(36)21(27)14-19-8-10-20(33)11-9-19)24(35)29-16-23(34)31(2)22(26(37)28-12-13-32)15-18-6-4-3-5-7-18/h3-11,17,21-22,32-33H,12-16,27H2,1-2H3,(H,28,37)(H,29,35)(H,30,36)/t17-,21+,22+/m1/s1
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5.00E+3n/an/an/an/an/an/an/an/a



Addiction Research Foundation

Curated by PDSP Ki Database




Genomics 28: 84-91 (1995)

More data for this
Ligand-Target Pair
neuropeptides B/W receptor 1


(Homo sapiens)
BDBM50019574
PNG
(CHEMBL406014 | CTOP | D-Phe-Cys-Tyr-D-Trp-Orn-Thr-...)
Show SMILES C[C@@H](O)[C@H](NC(=O)[C@@H]1NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CSSC1(C)C)NC(=O)[C@H](N)Cc1ccccc1)[C@@H](C)O)C(N)=O
Show InChI InChI=1S/C50H67N11O11S2/c1-26(62)39(42(53)65)59-49(72)41-50(3,4)74-73-25-38(58-43(66)33(52)21-28-11-6-5-7-12-28)47(70)56-36(22-29-16-18-31(64)19-17-29)45(68)57-37(23-30-24-54-34-14-9-8-13-32(30)34)46(69)55-35(15-10-20-51)44(67)60-40(27(2)63)48(71)61-41/h5-9,11-14,16-19,24,26-27,33,35-41,54,62-64H,10,15,20-23,25,51-52H2,1-4H3,(H2,53,65)(H,55,69)(H,56,70)(H,57,68)(H,58,66)(H,59,72)(H,60,67)(H,61,71)/t26-,27-,33-,35+,36+,37-,38+,39+,40-,41+/m1/s1
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5.00E+3n/an/an/an/an/an/an/an/a



Addiction Research Foundation

Curated by PDSP Ki Database




Genomics 28: 84-91 (1995)

More data for this
Ligand-Target Pair
neuropeptides B/W receptor 1


(Homo sapiens)
BDBM21008
PNG
((4S,7S,13S)-13-[(2S)-2-amino-3-(4-hydroxyphenyl)pr...)
Show SMILES CC1(C)SSC(C)(C)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H]1C(O)=O
Show InChI InChI=1S/C30H39N5O7S2/c1-29(2)23(34-25(38)20(31)14-18-10-12-19(36)13-11-18)27(40)32-16-22(37)33-21(15-17-8-6-5-7-9-17)26(39)35-24(28(41)42)30(3,4)44-43-29/h5-13,20-21,23-24,36H,14-16,31H2,1-4H3,(H,32,40)(H,33,37)(H,34,38)(H,35,39)(H,41,42)/t20-,21-,23-,24-/m0/s1
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5.00E+3n/an/an/an/an/an/an/an/a



Addiction Research Foundation

Curated by PDSP Ki Database




Genomics 28: 84-91 (1995)

More data for this
Ligand-Target Pair
neuropeptides B/W receptor 1


(Homo sapiens)
BDBM50362414
PNG
(CHEMBL1940537)
Show SMILES COc1ccc(cc1)C1(CCC1)N[C@@H]1CC[C@@H]([C@H](C1)c1ccsc1)C(=O)N1CCN(CC1)c1nc2ccccc2o1
Show InChI InChI=1S/C33H38N4O3S/c1-39-26-10-7-24(8-11-26)33(14-4-15-33)35-25-9-12-27(28(21-25)23-13-20-41-22-23)31(38)36-16-18-37(19-17-36)32-34-29-5-2-3-6-30(29)40-32/h2-3,5-8,10-11,13,20,22,25,27-28,35H,4,9,12,14-19,21H2,1H3/t25-,27+,28-/m1/s1
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n/an/a 4.20n/an/an/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Displacement of [125]-hNPW23 from human NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
neuropeptides B/W receptor 1


(Homo sapiens)
BDBM50362412
PNG
(CHEMBL1940539)
Show SMILES COc1ccc(cc1)C1(CCC1)N[C@@H]1CC[C@@H]([C@H](C1)c1ccsc1)C(=O)N1CCN(CC1)c1nc2ccccc2[nH]1
Show InChI InChI=1S/C33H39N5O2S/c1-40-26-10-7-24(8-11-26)33(14-4-15-33)36-25-9-12-27(28(21-25)23-13-20-41-22-23)31(39)37-16-18-38(19-17-37)32-34-29-5-2-3-6-30(29)35-32/h2-3,5-8,10-11,13,20,22,25,27-28,36H,4,9,12,14-19,21H2,1H3,(H,34,35)/t25-,27+,28-/m1/s1
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n/an/a 5.90n/an/an/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Displacement of [125]-hNPW23 from human NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
neuropeptides B/W receptor 1


(Homo sapiens)
BDBM50362409
PNG
(CHEMBL1940543)
Show SMILES COc1ccc(cc1)C1(CCC1)N[C@@H]1CC[C@@H]([C@H](C1)c1ccsc1)C(=O)N1CCN(CC1)c1nc2cc(C)ccc2o1
Show InChI InChI=1S/C34H40N4O3S/c1-23-4-11-31-30(20-23)35-33(41-31)38-17-15-37(16-18-38)32(39)28-10-7-26(21-29(28)24-12-19-42-22-24)36-34(13-3-14-34)25-5-8-27(40-2)9-6-25/h4-6,8-9,11-12,19-20,22,26,28-29,36H,3,7,10,13-18,21H2,1-2H3/t26-,28+,29-/m1/s1
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n/an/a 6n/an/an/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Displacement of [125]-hNPW23 from human NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
neuropeptides B/W receptor 1


(Homo sapiens)
BDBM50362412
PNG
(CHEMBL1940539)
Show SMILES COc1ccc(cc1)C1(CCC1)N[C@@H]1CC[C@@H]([C@H](C1)c1ccsc1)C(=O)N1CCN(CC1)c1nc2ccccc2[nH]1
Show InChI InChI=1S/C33H39N5O2S/c1-40-26-10-7-24(8-11-26)33(14-4-15-33)36-25-9-12-27(28(21-25)23-13-20-41-22-23)31(39)37-16-18-38(19-17-37)32-34-29-5-2-3-6-30(29)35-32/h2-3,5-8,10-11,13,20,22,25,27-28,36H,4,9,12,14-19,21H2,1H3,(H,34,35)/t25-,27+,28-/m1/s1
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n/an/a 11n/an/an/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Antagonist activity at human NPBWR1 expressed in CHO-K1 cells assessed as inhibition of hNPW23 and forskolin-stimulated cAMP production after 1 hr by...


Citation and Details
More data for this
Ligand-Target Pair
neuropeptides B/W receptor 1


(Homo sapiens)
BDBM50362410
PNG
(CHEMBL1940542)
Show SMILES COc1ccc(cc1)C1(CCC1)N[C@@H]1CC[C@@H]([C@H](C1)c1ccsc1)C(=O)N1CCN(CC1)c1nnc(Br)s1
Show InChI InChI=1S/C28H34BrN5O2S2/c1-36-22-6-3-20(4-7-22)28(10-2-11-28)30-21-5-8-23(24(17-21)19-9-16-37-18-19)25(35)33-12-14-34(15-13-33)27-32-31-26(29)38-27/h3-4,6-7,9,16,18,21,23-24,30H,2,5,8,10-15,17H2,1H3/t21-,23+,24-/m1/s1
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n/an/a 18n/an/an/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Displacement of [125]-hNPW23 from human NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
neuropeptides B/W receptor 1


(Homo sapiens)
BDBM50362415
PNG
(CHEMBL1940536)
Show SMILES COc1ccc(cc1)C(C)(C)N[C@@H]1CC[C@@H]([C@H](C1)c1ccsc1)C(=O)N1CCN(CC1)c1nc2ccccc2o1
Show InChI InChI=1S/C32H38N4O3S/c1-32(2,23-8-11-25(38-3)12-9-23)34-24-10-13-26(27(20-24)22-14-19-40-21-22)30(37)35-15-17-36(18-16-35)31-33-28-6-4-5-7-29(28)39-31/h4-9,11-12,14,19,21,24,26-27,34H,10,13,15-18,20H2,1-3H3/t24-,26+,27-/m1/s1
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n/an/a 21n/an/an/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Displacement of [125]-hNPW23 from human NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
neuropeptides B/W receptor 1


(Homo sapiens)
BDBM50362413
PNG
(CHEMBL1940538)
Show SMILES COc1ccc(cc1)C(C)(C)N[C@@H]1CC[C@@H]([C@H](C1)c1ccsc1)C(=O)N1CCN(CC1)c1nc2ccccc2[nH]1
Show InChI InChI=1S/C32H39N5O2S/c1-32(2,23-8-11-25(39-3)12-9-23)35-24-10-13-26(27(20-24)22-14-19-40-21-22)30(38)36-15-17-37(18-16-36)31-33-28-6-4-5-7-29(28)34-31/h4-9,11-12,14,19,21,24,26-27,35H,10,13,15-18,20H2,1-3H3,(H,33,34)/t24-,26+,27-/m1/s1
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n/an/a 35n/an/an/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Displacement of [125]-hNPW23 from human NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
neuropeptides B/W receptor 1


(Homo sapiens)
BDBM50362413
PNG
(CHEMBL1940538)
Show SMILES COc1ccc(cc1)C(C)(C)N[C@@H]1CC[C@@H]([C@H](C1)c1ccsc1)C(=O)N1CCN(CC1)c1nc2ccccc2[nH]1
Show InChI InChI=1S/C32H39N5O2S/c1-32(2,23-8-11-25(39-3)12-9-23)35-24-10-13-26(27(20-24)22-14-19-40-21-22)30(38)36-15-17-37(18-16-36)31-33-28-6-4-5-7-29(28)34-31/h4-9,11-12,14,19,21,24,26-27,35H,10,13,15-18,20H2,1-3H3,(H,33,34)/t24-,26+,27-/m1/s1
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n/an/a 39n/an/an/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Antagonist activity at human NPBWR1 expressed in CHO-K1 cells assessed as inhibition of hNPW23 and forskolin-stimulated cAMP production after 1 hr by...


Citation and Details
More data for this
Ligand-Target Pair
neuropeptides B/W receptor 1


(Homo sapiens)
BDBM50362414
PNG
(CHEMBL1940537)
Show SMILES COc1ccc(cc1)C1(CCC1)N[C@@H]1CC[C@@H]([C@H](C1)c1ccsc1)C(=O)N1CCN(CC1)c1nc2ccccc2o1
Show InChI InChI=1S/C33H38N4O3S/c1-39-26-10-7-24(8-11-26)33(14-4-15-33)35-25-9-12-27(28(21-25)23-13-20-41-22-23)31(38)36-16-18-37(19-17-36)32-34-29-5-2-3-6-30(29)40-32/h2-3,5-8,10-11,13,20,22,25,27-28,35H,4,9,12,14-19,21H2,1H3/t25-,27+,28-/m1/s1
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n/an/a 40n/an/an/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Antagonist activity at human NPBWR1 expressed in CHO-K1 cells assessed as inhibition of hNPW23 and forskolin-stimulated cAMP production after 1 hr by...


Citation and Details
More data for this
Ligand-Target Pair
neuropeptides B/W receptor 1


(Homo sapiens)
BDBM50362409
PNG
(CHEMBL1940543)
Show SMILES COc1ccc(cc1)C1(CCC1)N[C@@H]1CC[C@@H]([C@H](C1)c1ccsc1)C(=O)N1CCN(CC1)c1nc2cc(C)ccc2o1
Show InChI InChI=1S/C34H40N4O3S/c1-23-4-11-31-30(20-23)35-33(41-31)38-17-15-37(16-18-38)32(39)28-10-7-26(21-29(28)24-12-19-42-22-24)36-34(13-3-14-34)25-5-8-27(40-2)9-6-25/h4-6,8-9,11-12,19-20,22,26,28-29,36H,3,7,10,13-18,21H2,1-2H3/t26-,28+,29-/m1/s1
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n/an/a 70n/an/an/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Antagonist activity at human NPBWR1 expressed in CHO-K1 cells assessed as inhibition of hNPW23 and forskolin-stimulated cAMP production after 1 hr by...


Citation and Details
More data for this
Ligand-Target Pair
neuropeptides B/W receptor 1


(Homo sapiens)
BDBM50362411
PNG
(CHEMBL1940541)
Show SMILES COc1ccc(cc1)C1(CCC1)N[C@@H]1CC[C@@H]([C@H](C1)c1ccsc1)C(=O)N1CCN(CC1)c1nnc(s1)C(F)(F)F
Show InChI InChI=1S/C29H34F3N5O2S2/c1-39-22-6-3-20(4-7-22)28(10-2-11-28)33-21-5-8-23(24(17-21)19-9-16-40-18-19)25(38)36-12-14-37(15-13-36)27-35-34-26(41-27)29(30,31)32/h3-4,6-7,9,16,18,21,23-24,33H,2,5,8,10-15,17H2,1H3/t21-,23+,24-/m1/s1
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n/an/a 95n/an/an/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Displacement of [125]-hNPW23 from human NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
neuropeptides B/W receptor 1


(Homo sapiens)
BDBM50425599
PNG
(CHEMBL2314291)
Show SMILES CCOc1ccc(Oc2c(Cl)cnn(Cc3cccc4ccccc34)c2=O)cc1
Show InChI InChI=1S/C23H19ClN2O3/c1-2-28-18-10-12-19(13-11-18)29-22-21(24)14-25-26(23(22)27)15-17-8-5-7-16-6-3-4-9-20(16)17/h3-14H,2,15H2,1H3
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n/an/a 100n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR ass...


Citation and Details
More data for this
Ligand-Target Pair
neuropeptides B/W receptor 1


(Homo sapiens)
BDBM50362415
PNG
(CHEMBL1940536)
Show SMILES COc1ccc(cc1)C(C)(C)N[C@@H]1CC[C@@H]([C@H](C1)c1ccsc1)C(=O)N1CCN(CC1)c1nc2ccccc2o1
Show InChI InChI=1S/C32H38N4O3S/c1-32(2,23-8-11-25(38-3)12-9-23)34-24-10-13-26(27(20-24)22-14-19-40-21-22)30(37)35-15-17-36(18-16-35)31-33-28-6-4-5-7-29(28)39-31/h4-9,11-12,14,19,21,24,26-27,34H,10,13,15-18,20H2,1-3H3/t24-,26+,27-/m1/s1
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n/an/a 110n/an/an/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Antagonist activity at human NPBWR1 expressed in CHO-K1 cells assessed as inhibition of hNPW23 and forskolin-stimulated cAMP production after 1 hr by...


Citation and Details
More data for this
Ligand-Target Pair
neuropeptides B/W receptor 1


(Homo sapiens)
BDBM50425598
PNG
(CHEMBL1972527)
Show SMILES COc1ccc(Oc2c(Cl)cnn(C3c4ccccc4-c4ccccc34)c2=O)cc1
Show InChI InChI=1S/C24H17ClN2O3/c1-29-15-10-12-16(13-11-15)30-23-21(25)14-26-27(24(23)28)22-19-8-4-2-6-17(19)18-7-3-5-9-20(18)22/h2-14,22H,1H3
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n/an/a 120n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR ass...


Citation and Details
More data for this
Ligand-Target Pair
neuropeptides B/W receptor 1


(Homo sapiens)
BDBM50425597
PNG
(CHEMBL2314320)
Show SMILES COc1ccc(Oc2c(Cl)cnn(Cc3cccc4ccccc34)c2=O)cc1
Show InChI InChI=1S/C22H17ClN2O3/c1-27-17-9-11-18(12-10-17)28-21-20(23)13-24-25(22(21)26)14-16-7-4-6-15-5-2-3-8-19(15)16/h2-13H,14H2,1H3
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n/an/a 140n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR ass...


Citation and Details
More data for this
Ligand-Target Pair
neuropeptides B/W receptor 1


(Homo sapiens)
BDBM50401576
PNG
(CHEMBL2207117)
Show SMILES COc1ccc(Oc2c(Cl)cnn(-c3ccc4ccccc4c3)c2=O)cc1
Show InChI InChI=1S/C21H15ClN2O3/c1-26-17-8-10-18(11-9-17)27-20-19(22)13-23-24(21(20)25)16-7-6-14-4-2-3-5-15(14)12-16/h2-13H,1H3
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n/an/a 160n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human NPBWR1 expressed in HEK293T cells co-expressing Galphaqi3 assessed as calcium release after 15 mins by FLIPR assay assay


Citation and Details
More data for this
Ligand-Target Pair
neuropeptides B/W receptor 1


(Homo sapiens)
BDBM50362410
PNG
(CHEMBL1940542)
Show SMILES COc1ccc(cc1)C1(CCC1)N[C@@H]1CC[C@@H]([C@H](C1)c1ccsc1)C(=O)N1CCN(CC1)c1nnc(Br)s1
Show InChI InChI=1S/C28H34BrN5O2S2/c1-36-22-6-3-20(4-7-22)28(10-2-11-28)30-21-5-8-23(24(17-21)19-9-16-37-18-19)25(35)33-12-14-34(15-13-33)27-32-31-26(29)38-27/h3-4,6-7,9,16,18,21,23-24,30H,2,5,8,10-15,17H2,1H3/t21-,23+,24-/m1/s1
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n/an/a 197n/an/an/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Antagonist activity at human NPBWR1 expressed in CHO-K1 cells assessed as inhibition of hNPW23 and forskolin-stimulated cAMP production after 1 hr by...


Citation and Details
More data for this
Ligand-Target Pair
neuropeptides B/W receptor 1


(Homo sapiens)
BDBM50401572
PNG
(CHEMBL2207121)
Show SMILES CCOc1ccc(Oc2c(Cl)cnn(-c3cc(C)cc(C)c3)c2=O)cc1
Show InChI InChI=1S/C20H19ClN2O3/c1-4-25-16-5-7-17(8-6-16)26-19-18(21)12-22-23(20(19)24)15-10-13(2)9-14(3)11-15/h5-12H,4H2,1-3H3
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n/an/a 210n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human NPBWR1 expressed in HEK293T cells co-expressing Galphaqi3 assessed as calcium release after 15 mins by FLIPR assay assay


Citation and Details
More data for this
Ligand-Target Pair
neuropeptides B/W receptor 1


(Homo sapiens)
BDBM50425596
PNG
(CHEMBL1981304)
Show SMILES COc1ccc(Oc2c(Cl)cnn(Cc3ccccc3-n3cccn3)c2=O)cc1
Show InChI InChI=1S/C21H17ClN4O3/c1-28-16-7-9-17(10-8-16)29-20-18(22)13-24-26(21(20)27)14-15-5-2-3-6-19(15)25-12-4-11-23-25/h2-13H,14H2,1H3
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n/an/a 220n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR ass...


Citation and Details
More data for this
Ligand-Target Pair
neuropeptides B/W receptor 1


(Homo sapiens)
BDBM50425595
PNG
(CHEMBL2314323)
Show SMILES COc1ccc(Oc2c(Cl)cnn(Cc3c(C)ccc4ccccc34)c2=O)cc1
Show InChI InChI=1S/C23H19ClN2O3/c1-15-7-8-16-5-3-4-6-19(16)20(15)14-26-23(27)22(21(24)13-25-26)29-18-11-9-17(28-2)10-12-18/h3-13H,14H2,1-2H3
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n/an/a 220n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR ass...


Citation and Details
More data for this
Ligand-Target Pair
neuropeptides B/W receptor 1


(Homo sapiens)
BDBM50401577
PNG
(CHEMBL2207531)
Show SMILES CCc1cccc(c1)-n1ncc(Cl)c(Oc2ccc(OC)cc2)c1=O
Show InChI InChI=1S/C19H17ClN2O3/c1-3-13-5-4-6-14(11-13)22-19(23)18(17(20)12-21-22)25-16-9-7-15(24-2)8-10-16/h4-12H,3H2,1-2H3
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n/an/a 230n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human NPBWR1 expressed in HEK293T cells co-expressing Galphaqi3 assessed as calcium release after 15 mins by FLIPR assay assay


Citation and Details
More data for this
Ligand-Target Pair
neuropeptides B/W receptor 1


(Homo sapiens)
BDBM50425593
PNG
(CHEMBL2314301)
Show SMILES CCc1ccc(Oc2c(Cl)cnn(C3c4ccccc4-c4ccccc34)c2=O)cc1
Show InChI InChI=1S/C25H19ClN2O2/c1-2-16-11-13-17(14-12-16)30-24-22(26)15-27-28(25(24)29)23-20-9-5-3-7-18(20)19-8-4-6-10-21(19)23/h3-15,23H,2H2,1H3
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n/an/a 240n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR ass...


Citation and Details
More data for this
Ligand-Target Pair
neuropeptides B/W receptor 1


(Homo sapiens)
BDBM50425594
PNG
(CHEMBL1987422)
Show SMILES COc1ccc(Oc2c(Cl)cnn(Cc3c(C)cccc3C)c2=O)cc1
Show InChI InChI=1S/C20H19ClN2O3/c1-13-5-4-6-14(2)17(13)12-23-20(24)19(18(21)11-22-23)26-16-9-7-15(25-3)8-10-16/h4-11H,12H2,1-3H3
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n/an/a 240n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR ass...


Citation and Details
More data for this
Ligand-Target Pair
neuropeptides B/W receptor 1


(Homo sapiens)
BDBM50425591
PNG
(CHEMBL2314300)
Show SMILES CCOc1ccc(Oc2c(Cl)cnn(C3c4ccccc4-c4ccccc34)c2=O)cc1
Show InChI InChI=1S/C25H19ClN2O3/c1-2-30-16-11-13-17(14-12-16)31-24-22(26)15-27-28(25(24)29)23-20-9-5-3-7-18(20)19-8-4-6-10-21(19)23/h3-15,23H,2H2,1H3
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n/an/a 250n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR ass...


Citation and Details
More data for this
Ligand-Target Pair
neuropeptides B/W receptor 1


(Homo sapiens)
BDBM50425592
PNG
(CHEMBL2314293)
Show SMILES CCc1ccc(Oc2c(Cl)cnn(Cc3cccc4ccccc34)c2=O)cc1
Show InChI InChI=1S/C23H19ClN2O2/c1-2-16-10-12-19(13-11-16)28-22-21(24)14-25-26(23(22)27)15-18-8-5-7-17-6-3-4-9-20(17)18/h3-14H,2,15H2,1H3
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n/an/a 250n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR ass...


Citation and Details
More data for this
Ligand-Target Pair
neuropeptides B/W receptor 1


(Homo sapiens)
BDBM50425590
PNG
(CHEMBL1964671)
Show SMILES CCc1ccccc1Cn1ncc(Cl)c(Oc2ccc(OC)cc2)c1=O
Show InChI InChI=1S/C20H19ClN2O3/c1-3-14-6-4-5-7-15(14)13-23-20(24)19(18(21)12-22-23)26-17-10-8-16(25-2)9-11-17/h4-12H,3,13H2,1-2H3
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n/an/a 260n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR ass...


Citation and Details
More data for this
Ligand-Target Pair
neuropeptides B/W receptor 1


(Homo sapiens)
BDBM75938
PNG
(5-chloranyl-4-(4-methoxyphenoxy)-2-(4-propan-2-ylp...)
Show SMILES COc1ccc(Oc2c(Cl)cnn(-c3ccc(cc3)C(C)C)c2=O)cc1
Show InChI InChI=1S/C20H19ClN2O3/c1-13(2)14-4-6-15(7-5-14)23-20(24)19(18(21)12-22-23)26-17-10-8-16(25-3)9-11-17/h4-13H,1-3H3
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The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...


Citation and Details
More data for this
Ligand-Target Pair
neuropeptides B/W receptor 1


(Homo sapiens)
BDBM75901
PNG
(5-chloranyl-2-(3,5-dimethylphenyl)-4-(4-methoxyphe...)
Show SMILES COc1ccc(Oc2c(Cl)cnn(-c3cc(C)cc(C)c3)c2=O)cc1
Show InChI InChI=1S/C19H17ClN2O3/c1-12-8-13(2)10-14(9-12)22-19(23)18(17(20)11-21-22)25-16-6-4-15(24-3)5-7-16/h4-11H,1-3H3
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The Scripps Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR ass...


Citation and Details
More data for this
Ligand-Target Pair
neuropeptides B/W receptor 1


(Homo sapiens)
BDBM75901
PNG
(5-chloranyl-2-(3,5-dimethylphenyl)-4-(4-methoxyphe...)
Show SMILES COc1ccc(Oc2c(Cl)cnn(-c3cc(C)cc(C)c3)c2=O)cc1
Show InChI InChI=1S/C19H17ClN2O3/c1-12-8-13(2)10-14(9-12)22-19(23)18(17(20)11-21-22)25-16-6-4-15(24-3)5-7-16/h4-11H,1-3H3
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The Scripps Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human NPBWR1 expressed in HEK293T cells co-expressing Galphaqi3 assessed as calcium release after 15 mins by FLIPR assay assay


Citation and Details
More data for this
Ligand-Target Pair
neuropeptides B/W receptor 1


(Homo sapiens)
BDBM75938
PNG
(5-chloranyl-4-(4-methoxyphenoxy)-2-(4-propan-2-ylp...)
Show SMILES COc1ccc(Oc2c(Cl)cnn(-c3ccc(cc3)C(C)C)c2=O)cc1
Show InChI InChI=1S/C20H19ClN2O3/c1-13(2)14-4-6-15(7-5-14)23-20(24)19(18(21)12-22-23)26-17-10-8-16(25-3)9-11-17/h4-13H,1-3H3
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The Scripps Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human NPBWR1 expressed in HEK293T cells co-expressing Galphaqi3 assessed as calcium release after 15 mins by FLIPR assay assay


Citation and Details
More data for this
Ligand-Target Pair
neuropeptides B/W receptor 1


(Homo sapiens)
BDBM75901
PNG
(5-chloranyl-2-(3,5-dimethylphenyl)-4-(4-methoxyphe...)
Show SMILES COc1ccc(Oc2c(Cl)cnn(-c3cc(C)cc(C)c3)c2=O)cc1
Show InChI InChI=1S/C19H17ClN2O3/c1-12-8-13(2)10-14(9-12)22-19(23)18(17(20)11-21-22)25-16-6-4-15(24-3)5-7-16/h4-11H,1-3H3
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The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...


Citation and Details
More data for this
Ligand-Target Pair
neuropeptides B/W receptor 1


(Homo sapiens)
BDBM75900
PNG
(5-chloranyl-4-(4-methoxyphenoxy)-2-(3-propan-2-ylp...)
Show SMILES COc1ccc(Oc2c(Cl)cnn(-c3cccc(c3)C(C)C)c2=O)cc1
Show InChI InChI=1S/C20H19ClN2O3/c1-13(2)14-5-4-6-15(11-14)23-20(24)19(18(21)12-22-23)26-17-9-7-16(25-3)8-10-17/h4-13H,1-3H3
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The Scripps Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human NPBWR1 expressed in HEK293T cells co-expressing Galphaqi3 assessed as calcium release after 15 mins by FLIPR assay assay


Citation and Details
More data for this
Ligand-Target Pair
neuropeptides B/W receptor 1


(Homo sapiens)
BDBM75900
PNG
(5-chloranyl-4-(4-methoxyphenoxy)-2-(3-propan-2-ylp...)
Show SMILES COc1ccc(Oc2c(Cl)cnn(-c3cccc(c3)C(C)C)c2=O)cc1
Show InChI InChI=1S/C20H19ClN2O3/c1-13(2)14-5-4-6-15(11-14)23-20(24)19(18(21)12-22-23)26-17-9-7-16(25-3)8-10-17/h4-13H,1-3H3
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The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...


Citation and Details
More data for this
Ligand-Target Pair
neuropeptides B/W receptor 1


(Homo sapiens)
BDBM50425589
PNG
(CHEMBL1969065)
Show SMILES COc1ccc(Oc2c(Cl)cnn(CC(=O)N(c3ccccc3)c3ccccc3)c2=O)cc1
Show InChI InChI=1S/C25H20ClN3O4/c1-32-20-12-14-21(15-13-20)33-24-22(26)16-27-28(25(24)31)17-23(30)29(18-8-4-2-5-9-18)19-10-6-3-7-11-19/h2-16H,17H2,1H3
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The Scripps Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR ass...


Citation and Details
More data for this
Ligand-Target Pair
neuropeptides B/W receptor 1


(Homo sapiens)
BDBM75901
PNG
(5-chloranyl-2-(3,5-dimethylphenyl)-4-(4-methoxyphe...)
Show SMILES COc1ccc(Oc2c(Cl)cnn(-c3cc(C)cc(C)c3)c2=O)cc1
Show InChI InChI=1S/C19H17ClN2O3/c1-12-8-13(2)10-14(9-12)22-19(23)18(17(20)11-21-22)25-16-6-4-15(24-3)5-7-16/h4-11H,1-3H3
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The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
neuropeptides B/W receptor 1


(Homo sapiens)
BDBM75946
PNG
(2-[3,5-bis(chloranyl)phenyl]-5-chloranyl-4-(4-meth...)
Show SMILES COc1ccc(Oc2c(Cl)cnn(-c3cc(Cl)cc(Cl)c3)c2=O)cc1
Show InChI InChI=1S/C17H11Cl3N2O3/c1-24-13-2-4-14(5-3-13)25-16-15(20)9-21-22(17(16)23)12-7-10(18)6-11(19)8-12/h2-9H,1H3
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n/an/a 287n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...


Citation and Details
More data for this
Ligand-Target Pair
neuropeptides B/W receptor 1


(Homo sapiens)
BDBM50425588
PNG
(CHEMBL1965488)
Show SMILES COc1ccc(Oc2c(Cl)cnn(Cc3cccc4ccccc34)c2=O)cc1OC
Show InChI InChI=1S/C23H19ClN2O4/c1-28-20-11-10-17(12-21(20)29-2)30-22-19(24)13-25-26(23(22)27)14-16-8-5-7-15-6-3-4-9-18(15)16/h3-13H,14H2,1-2H3
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The Scripps Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR ass...


Citation and Details
More data for this
Ligand-Target Pair
neuropeptides B/W receptor 1


(Homo sapiens)
BDBM75918
PNG
(5-chloranyl-4-(4-methoxyphenoxy)-2-(3-methyl-4-pro...)
Show SMILES COc1ccc(Oc2c(Cl)cnn(-c3ccc(C(C)C)c(C)c3)c2=O)cc1
Show InChI InChI=1S/C21H21ClN2O3/c1-13(2)18-10-5-15(11-14(18)3)24-21(25)20(19(22)12-23-24)27-17-8-6-16(26-4)7-9-17/h5-13H,1-4H3
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n/an/a 299n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...


Citation and Details
More data for this
Ligand-Target Pair
neuropeptides B/W receptor 1


(Homo sapiens)
BDBM75918
PNG
(5-chloranyl-4-(4-methoxyphenoxy)-2-(3-methyl-4-pro...)
Show SMILES COc1ccc(Oc2c(Cl)cnn(-c3ccc(C(C)C)c(C)c3)c2=O)cc1
Show InChI InChI=1S/C21H21ClN2O3/c1-13(2)18-10-5-15(11-14(18)3)24-21(25)20(19(22)12-23-24)27-17-8-6-16(26-4)7-9-17/h5-13H,1-4H3
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The Scripps Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human NPBWR1 expressed in HEK293T cells co-expressing Galphaqi3 assessed as calcium release after 15 mins by FLIPR assay assay


Citation and Details
More data for this
Ligand-Target Pair
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