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Found 5882 hits Enz. Inhib. hit(s) with Target = 'serotonin 1 (5-ht1) receptor'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM?mit=repeat
Kd
nM
EC50/IC50
nM?mit=repeat
koff
s-1
kon
M-1s-1
pHTemp
°C
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50035305
PNG
((S)-8-Dipropylamino-6,7,8,9-tetrahydro-3H-benzo[e]...)
Show SMILES CCCN(CCC)[C@H]1CCc2ccc3[nH]cc(C=O)c3c2C1
Show InChI InChI=1S/C19H26N2O/c1-3-9-21(10-4-2)16-7-5-14-6-8-18-19(17(14)11-16)15(13-22)12-20-18/h6,8,12-13,16,20H,3-5,7,9-11H2,1-2H3/t16-/m0/s1
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0.200n/an/an/an/an/an/an/an/a



Göteborg University

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor from CHO-K1 cells, using [3H]-8-OH-DPAT as the radioligand.


J Med Chem 38: 2202-16 (1995)


Article DOI: 10.1021/jm00012a021
BindingDB Entry DOI: 10.7270/Q24T6HD0
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50035303
PNG
((R)-8-Dipropylamino-6,7,8,9-tetrahydro-3H-benzo[e]...)
Show SMILES CCCN(CCC)[C@@H]1CCc2ccc3[nH]cc(C=O)c3c2C1
Show InChI InChI=1S/C19H26N2O/c1-3-9-21(10-4-2)16-7-5-14-6-8-18-19(17(14)11-16)15(13-22)12-20-18/h6,8,12-13,16,20H,3-5,7,9-11H2,1-2H3/t16-/m1/s1
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0.200n/an/an/an/an/an/an/an/a



Göteborg University

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor from CHO-K1 cells, using [3H]-8-OH-DPAT as the radioligand.


J Med Chem 38: 2202-16 (1995)


Article DOI: 10.1021/jm00012a021
BindingDB Entry DOI: 10.7270/Q24T6HD0
More data for this
Ligand-Target Pair
Serotonin 1 (5-HT1) receptor


(Rattus norvegicus (rat))
BDBM50035320
PNG
((+/-)-8-Dipropylamino-6,7,8,9-tetrahydro-3H-benzo[...)
Show SMILES CCCN(CCC)C1CCc2ccc3[nH]cc(C=O)c3c2C1
Show InChI InChI=1S/C19H26N2O/c1-3-9-21(10-4-2)16-7-5-14-6-8-18-19(17(14)11-16)15(13-22)12-20-18/h6,8,12-13,16,20H,3-5,7,9-11H2,1-2H3
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0.200n/an/an/an/an/an/an/an/a



University of Göteborg

Curated by ChEMBL


Assay Description
In vitro binding affinity against 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand in CHO-cells (sc)


J Med Chem 36: 2059-65 (1993)


Article DOI: 10.1021/jm00067a002
BindingDB Entry DOI: 10.7270/Q2MP52CR
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50064563
PNG
(CHEMBL61816 | [3-(4-Benzofuran-6-yl-piperazin-1-yl...)
Show SMILES O=C(N1CCCCC1)c1cccc(CN2CCN(CC2)c2ccc3ccoc3c2)c1
Show InChI InChI=1S/C25H29N3O2/c29-25(28-10-2-1-3-11-28)22-6-4-5-20(17-22)19-26-12-14-27(15-13-26)23-8-7-21-9-16-30-24(21)18-23/h4-9,16-18H,1-3,10-15,19H2
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0.210n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Compound was evaluated for its binding affinity against 5-hydroxytryptamine 1A receptor from rat cerebral cortex


J Med Chem 41: 1997-2009 (1998)


Article DOI: 10.1021/jm970164z
BindingDB Entry DOI: 10.7270/Q2KK9CG0
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50057436
PNG
(CHEMBL25213 | [2-(6-Fluoro-chroman-8-yloxy)-ethyl]...)
Show SMILES COc1ccc(CCCCNCCOc2cc(F)cc3CCCOc23)cc1
Show InChI InChI=1S/C22H28FNO3/c1-25-20-9-7-17(8-10-20)5-2-3-11-24-12-14-26-21-16-19(23)15-18-6-4-13-27-22(18)21/h7-10,15-16,24H,2-6,11-14H2,1H3
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0.220n/an/an/an/an/an/an/an/a



Yamanouchi Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT from rat hippocampal 5-hydroxytryptamine 1A receptor


J Med Chem 40: 1252-7 (1997)


Article DOI: 10.1021/jm960760d
BindingDB Entry DOI: 10.7270/Q20R9Q26
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50083280
PNG
(Adamantane-1-carboxylic acid {2-[4-(2-methoxy-phen...)
Show SMILES COc1ccccc1N1CCN(C[C@@H](C)NC(=O)C23C[C@H]4C[C@H](C[C@H](C4)C2)C3)CC1
Show InChI InChI=1S/C25H37N3O2/c1-18(26-24(29)25-14-19-11-20(15-25)13-21(12-19)16-25)17-27-7-9-28(10-8-27)22-5-3-4-6-23(22)30-2/h3-6,18-21H,7-17H2,1-2H3,(H,26,29)/t18-,19-,20+,21-,25?/m1/s1
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0.220n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Antagonist activity against rat hippocampal tissue 5-hydroxytryptamine 1A receptor


J Med Chem 42: 5077-94 (2000)


Article DOI: 10.1021/jm9806704
BindingDB Entry DOI: 10.7270/Q2C82B0P
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50122238
PNG
(4-Chloro-5-{4-[2-(2-ethoxy-phenoxy)-ethyl]-piperaz...)
Show SMILES CCOc1ccccc1OCCN1CCN(CC1)c1cnn(CCCCCCCN2CCN(CC2)c2ccccc2OCC)c(=O)c1Cl
Show InChI InChI=1S/C37H53ClN6O4/c1-3-46-33-15-9-8-14-31(33)42-24-20-40(21-25-42)18-12-6-5-7-13-19-44-37(45)36(38)32(30-39-44)43-26-22-41(23-27-43)28-29-48-35-17-11-10-16-34(35)47-4-2/h8-11,14-17,30H,3-7,12-13,18-29H2,1-2H3
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0.220n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 1A receptor receptor in rat cerebral cortex using [3H]-8-OH-DPAT


Bioorg Med Chem Lett 13: 171-3 (2002)


Article DOI: 10.1016/s0960-894x(02)00932-0
BindingDB Entry DOI: 10.7270/Q2TM79GX
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50057436
PNG
(CHEMBL25213 | [2-(6-Fluoro-chroman-8-yloxy)-ethyl]...)
Show SMILES COc1ccc(CCCCNCCOc2cc(F)cc3CCCOc23)cc1
Show InChI InChI=1S/C22H28FNO3/c1-25-20-9-7-17(8-10-20)5-2-3-11-24-12-14-26-21-16-19(23)15-18-6-4-13-27-22(18)21/h7-10,15-16,24H,2-6,11-14H2,1H3
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0.221n/an/an/an/an/an/an/an/a



Yamanouchi Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor on rat hippocampus using [3H]-8-OH-DPAT as radioligand.


J Med Chem 41: 2765-78 (1998)


Article DOI: 10.1021/jm9707840
BindingDB Entry DOI: 10.7270/Q2K073CQ
More data for this
Ligand-Target Pair
Serotonin 1 (5-HT1) receptor


(Rattus norvegicus (rat))
BDBM50403670
PNG
(CHEMBL311015)
Show SMILES O=C1N(CCCCN2CCN(CC2)c2cccc3OCCOc23)C(=O)c2ccccc12
Show InChI InChI=1S/C24H27N3O4/c28-23-18-6-1-2-7-19(18)24(29)27(23)11-4-3-10-25-12-14-26(15-13-25)20-8-5-9-21-22(20)31-17-16-30-21/h1-2,5-9H,3-4,10-17H2
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0.229n/an/an/an/an/an/an/an/a



Solvay Pharma

Curated by ChEMBL


Assay Description
Inhibition of [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor of rat frontal cortex membranes


Bioorg Med Chem Lett 8: 2457-62 (1999)


Article DOI: 10.1016/s0960-894x(98)00406-5
BindingDB Entry DOI: 10.7270/Q2KS6SQ1
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50034308
PNG
(Bicyclo[2.2.1]heptane-2-carboxylic acid {4-[4-(2-m...)
Show SMILES COc1ccccc1N1CCN(CCCCNC(=O)C2CC3CCC2C3)CC1
Show InChI InChI=1S/C23H35N3O2/c1-28-22-7-3-2-6-21(22)26-14-12-25(13-15-26)11-5-4-10-24-23(27)20-17-18-8-9-19(20)16-18/h2-3,6-7,18-20H,4-5,8-17H2,1H3,(H,24,27)
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0.230n/an/an/an/an/an/an/an/a



FAES, S.A.

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor sites of rat brain cortex.


J Med Chem 38: 1273-7 (1995)


Article DOI: 10.1021/jm00008a005
BindingDB Entry DOI: 10.7270/Q2H9947K
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50035366
PNG
(8-Azepan-1-yl-6,7,8,9-tetrahydro-3H-benzo[e]indole...)
Show SMILES O=Cc1c[nH]c2ccc3CCC(Cc3c12)N1CCCCCC1
Show InChI InChI=1S/C19H24N2O/c22-13-15-12-20-18-8-6-14-5-7-16(11-17(14)19(15)18)21-9-3-1-2-4-10-21/h6,8,12-13,16,20H,1-5,7,9-11H2
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0.240n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1A receptor expressed in CHO cells, by using [3H]8-OH-DPAT as radioligand.


J Med Chem 38: 2217-30 (1995)


Article DOI: 10.1021/jm00012a022
BindingDB Entry DOI: 10.7270/Q28G8MBW
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50083308
PNG
(CHEMBL555379 | Hexahydro-2,5-methano-pentalene-3a-...)
Show SMILES COc1ccccc1N1CCN(CCNC(=O)C23CC4C[C@@H]2C[C@@H](C3)C4)CC1
Show InChI InChI=1S/C23H33N3O2/c1-28-21-5-3-2-4-20(21)26-10-8-25(9-11-26)7-6-24-22(27)23-15-17-12-18(16-23)14-19(23)13-17/h2-5,17-19H,6-16H2,1H3,(H,24,27)/t17-,18?,19-,23?/m0/s1
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0.240n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Antagonist activity against rat hippocampal tissue 5-hydroxytryptamine 1A receptor


J Med Chem 42: 5077-94 (2000)


Article DOI: 10.1021/jm9806704
BindingDB Entry DOI: 10.7270/Q2C82B0P
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50034292
PNG
(CHEMBL25654 | Octahydro-pentalene-2-carboxylic aci...)
Show SMILES COc1ccccc1N1CCN(CCNC(=O)C2CC3CCCC3C2)CC1
Show InChI InChI=1S/C22H33N3O2/c1-27-21-8-3-2-7-20(21)25-13-11-24(12-14-25)10-9-23-22(26)19-15-17-5-4-6-18(17)16-19/h2-3,7-8,17-19H,4-6,9-16H2,1H3,(H,23,26)
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0.240n/an/an/an/an/an/an/an/a



FAES, S.A.

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor sites of rat brain cortex.


J Med Chem 38: 1273-7 (1995)


Article DOI: 10.1021/jm00008a005
BindingDB Entry DOI: 10.7270/Q2H9947K
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM86708
PNG
(CAS_146714-97-8 | CHEMBL31354 | CHEMBL514874 | CHE...)
Show SMILES COc1ccccc1N1CCN(CCN(C(=O)C2CCCCC2)c2ccccn2)CC1
Show InChI InChI=1S/C25H34N4O2/c1-31-23-12-6-5-11-22(23)28-18-15-27(16-19-28)17-20-29(24-13-7-8-14-26-24)25(30)21-9-3-2-4-10-21/h5-8,11-14,21H,2-4,9-10,15-20H2,1H3
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0.240n/an/an/an/an/an/an/an/a



Preclinical R & D, Astra Arcus AB

Curated by PDSP Ki Database




J Pharmacol Exp Ther 283: 216-25 (1997)


BindingDB Entry DOI: 10.7270/Q22Z142T
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50054342
PNG
(8-{4-[((R)-5-Fluoro-1,2,3,4-tetrahydro-naphthalen-...)
Show SMILES CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)[C@@H]1CCc2c(F)cccc2C1
Show InChI InChI=1S/C26H37FN2O2/c1-2-14-28(21-10-11-22-20(17-21)8-7-9-23(22)27)15-5-6-16-29-24(30)18-26(19-25(29)31)12-3-4-13-26/h7-9,21H,2-6,10-19H2,1H3/t21-/m1/s1
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0.246n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor


J Med Chem 39: 4421-9 (1996)


Article DOI: 10.1021/jm960350p
BindingDB Entry DOI: 10.7270/Q21G0KCQ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50039822
PNG
(1-(2-Cyclohexyl-ethyl)-4-(2,3-dihydro-benzo[1,4]di...)
Show SMILES C(CN1CCN(CC1)c1cccc2OCCOc12)C1CCCCC1
Show InChI InChI=1S/C20H30N2O2/c1-2-5-17(6-3-1)9-10-21-11-13-22(14-12-21)18-7-4-8-19-20(18)24-16-15-23-19/h4,7-8,17H,1-3,5-6,9-16H2
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0.25n/an/an/an/an/an/an/an/a



Solvay Duphar Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to displace [3H]2-(di-N-propylamino)-8-hydroxy-tetralin from 5-hydroxytryptamine 1A (5-HT1A) receptor in rat frontal cortex homogena...


J Med Chem 37: 2761-73 (1994)


Article DOI: 10.1021/jm00043a015
BindingDB Entry DOI: 10.7270/Q2DJ5G84
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50039822
PNG
(1-(2-Cyclohexyl-ethyl)-4-(2,3-dihydro-benzo[1,4]di...)
Show SMILES C(CN1CCN(CC1)c1cccc2OCCOc12)C1CCCCC1
Show InChI InChI=1S/C20H30N2O2/c1-2-5-17(6-3-1)9-10-21-11-13-22(14-12-21)18-7-4-8-19-20(18)24-16-15-23-19/h4,7-8,17H,1-3,5-6,9-16H2
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0.25n/an/an/an/an/an/an/an/a



Solvay Duphar Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of radioligand [3H]-2-(di-N-propylamino)-8-hydroxytetralin from 5-hydroxytryptamine 1A receptor in rat frontal cortex homogenate


J Med Chem 36: 2751-60 (1993)


Article DOI: 10.1021/jm00071a006
BindingDB Entry DOI: 10.7270/Q2CZ367F
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50029262
PNG
(Pentanoic acid {5-[4-(2-isopropoxy-phenyl)-piperaz...)
Show SMILES CCCCC(=O)N(C)Cc1ccc(CN2CCN(CC2)c2ccccc2OC(C)C)n1C
Show InChI InChI=1S/C26H40N4O2/c1-6-7-12-26(31)27(4)19-22-13-14-23(28(22)5)20-29-15-17-30(18-16-29)24-10-8-9-11-25(24)32-21(2)3/h8-11,13-14,21H,6-7,12,15-20H2,1-5H3
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0.25n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity was determined against 5-hydroxytryptamine 1A receptor using [3H]WB-4101


J Med Chem 38: 4198-210 (1995)


Article DOI: 10.1021/jm00021a009
BindingDB Entry DOI: 10.7270/Q2GX4C61
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50088686
PNG
(3-Amino-2-{3-[4-(2-methoxy-phenyl)-piperazin-1-yl]...)
Show SMILES COc1ccccc1N1CCN(CCCSc2nc3sc4CCCc4c3c(=O)n2N)CC1
Show InChI InChI=1S/C23H29N5O2S2/c1-30-18-8-3-2-7-17(18)27-13-11-26(12-14-27)10-5-15-31-23-25-21-20(22(29)28(23)24)16-6-4-9-19(16)32-21/h2-3,7-8H,4-6,9-15,24H2,1H3
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0.260n/an/an/an/an/an/an/an/a



Università di Catania

Curated by ChEMBL


Assay Description
Displacement of [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor of rat hippocampus membranes


Bioorg Med Chem Lett 10: 1089-92 (2000)


Article DOI: 10.1016/s0960-894x(00)00165-7
BindingDB Entry DOI: 10.7270/Q25D8R2B
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM85827
PNG
((R)-3-[Isopropyl(propyl)amino]-3,4-dihydro-2H-1-be...)
Show SMILES CCCN(C(C)C)[C@H]1COc2cccc(C(N)=O)c2C1
Show InChI InChI=1S/C16H24N2O2/c1-4-8-18(11(2)3)12-9-14-13(16(17)19)6-5-7-15(14)20-10-12/h5-7,11-12H,4,8-10H2,1-3H3,(H2,17,19)/t12-/m1/s1
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0.260n/an/an/an/an/an/an/an/a



AstraZeneca R&D

Curated by PDSP Ki Database




J Pharmacol Exp Ther 299: 883-93 (2001)


BindingDB Entry DOI: 10.7270/Q2PK0DQ2
More data for this
Ligand-Target Pair
Serotonin 1B/1D receptor


(Rattus norvegicus (Rat))
BDBM81499
PNG
(CAS_155346 | CYANOPINDOLOL | CYANOPINDOLOL(+/-) | ...)
Show SMILES CC(C)(C)NCC(O)COc1cccc2[nH]c(cc12)C#N
Show InChI InChI=1S/C16H21N3O2/c1-16(2,3)18-9-12(20)10-21-15-6-4-5-14-13(15)7-11(8-17)19-14/h4-7,12,18-20H,9-10H2,1-3H3
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0.260n/an/an/an/an/an/an/an/a



University of Alberta

Curated by PDSP Ki Database




Neuropharmacology 33: 275-317


BindingDB Entry DOI: 10.7270/Q2M043X2
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50057434
PNG
(8-{2-[4-(4-Methoxy-phenyl)-butylamino]-ethoxy}-chr...)
Show SMILES COc1ccc(CCCCNCCOc2cc(O)cc3CCCOc23)cc1
Show InChI InChI=1S/C22H29NO4/c1-25-20-9-7-17(8-10-20)5-2-3-11-23-12-14-26-21-16-19(24)15-18-6-4-13-27-22(18)21/h7-10,15-16,23-24H,2-6,11-14H2,1H3
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0.270n/an/an/an/an/an/an/an/a



Yamanouchi Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT from rat hippocampal 5-hydroxytryptamine 1A receptor


J Med Chem 40: 1252-7 (1997)


Article DOI: 10.1021/jm960760d
BindingDB Entry DOI: 10.7270/Q20R9Q26
More data for this
Ligand-Target Pair
Serotonin 1 (5-HT1) receptor


(Rattus norvegicus (rat))
BDBM21393
PNG
(7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-o...)
Show SMILES CCCN(CCC)C1CCc2cccc(O)c2C1
Show InChI InChI=1S/C16H25NO/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14/h5-7,14,18H,3-4,8-12H2,1-2H3
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0.270n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]-8-OH-DPAT from rat hippocampal 5-hydroxytryptamine 1A receptor


Bioorg Med Chem Lett 3: 2035-2038 (1993)


Article DOI: 10.1016/S0960-894X(01)81009-X
BindingDB Entry DOI: 10.7270/Q2XW4JQH
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50034300
PNG
(Bicyclo[2.2.1]hept-5-ene-2-carboxylic acid {2-[4-(...)
Show SMILES COc1ccccc1N1CCN(CCNC(=O)C2CC3CC2C=C3)CC1
Show InChI InChI=1S/C21H29N3O2/c1-26-20-5-3-2-4-19(20)24-12-10-23(11-13-24)9-8-22-21(25)18-15-16-6-7-17(18)14-16/h2-7,16-18H,8-15H2,1H3,(H,22,25)
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0.270n/an/an/an/an/an/an/an/a



FAES, S.A.

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor sites of rat brain cortex.


J Med Chem 38: 1273-7 (1995)


Article DOI: 10.1021/jm00008a005
BindingDB Entry DOI: 10.7270/Q2H9947K
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50262744
PNG
(2-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]th...)
Show SMILES COc1ccccc1N1CCN(CCCSc2nc3ccccc3n2C)CC1
Show InChI InChI=1S/C22H28N4OS/c1-24-19-9-4-3-8-18(19)23-22(24)28-17-7-12-25-13-15-26(16-14-25)20-10-5-6-11-21(20)27-2/h3-6,8-11H,7,12-17H2,1-2H3
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0.270n/an/an/an/an/an/an/an/a



Università di Catania

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT from 5HT1A receptor in CRL:CD(SD)BR-COBS rat hippocampus


J Med Chem 51: 4529-38 (2008)


Article DOI: 10.1021/jm800176x
BindingDB Entry DOI: 10.7270/Q2Q81CWG
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50065573
PNG
(CHEMBL96222 | [2-(6-Fluoro-2-methyl-chroman-8-ylox...)
Show SMILES COc1ccc(CCCCNCCOc2cc(F)cc3CCC(C)Oc23)cc1
Show InChI InChI=1S/C23H30FNO3/c1-17-6-9-19-15-20(24)16-22(23(19)28-17)27-14-13-25-12-4-3-5-18-7-10-21(26-2)11-8-18/h7-8,10-11,15-17,25H,3-6,9,12-14H2,1-2H3
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0.270n/an/an/an/an/an/an/an/a



Yamanouchi Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor on rat hippocampus using [3H]-8-OH-DPAT as radioligand.


J Med Chem 41: 2765-78 (1998)


Article DOI: 10.1021/jm9707840
BindingDB Entry DOI: 10.7270/Q2K073CQ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50262787
PNG
(2-[[4-[4-(2-Methoxyphenyl)-1-piperazinyl]butyl]thi...)
Show SMILES COc1ccccc1N1CCN(CCCCSc2nc3ccccc3s2)CC1
Show InChI InChI=1S/C22H27N3OS2/c1-26-20-10-4-3-9-19(20)25-15-13-24(14-16-25)12-6-7-17-27-22-23-18-8-2-5-11-21(18)28-22/h2-5,8-11H,6-7,12-17H2,1H3
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0.270n/an/an/an/an/an/an/an/a



Università di Catania

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT from 5HT1A receptor in CRL:CD(SD)BR-COBS rat hippocampus


J Med Chem 51: 4529-38 (2008)


Article DOI: 10.1021/jm800176x
BindingDB Entry DOI: 10.7270/Q2Q81CWG
More data for this
Ligand-Target Pair
Serotonin 1 (5-HT1) receptor


(Rattus norvegicus (rat))
BDBM50403668
PNG
(CHEMBL312339)
Show SMILES O=C1N(CCCCN2CCN(CC2)c2cccc3OCCOc23)S(=O)(=O)c2ccccc12
Show InChI InChI=1S/C23H27N3O5S/c27-23-18-6-1-2-9-21(18)32(28,29)26(23)11-4-3-10-24-12-14-25(15-13-24)19-7-5-8-20-22(19)31-17-16-30-20/h1-2,5-9H,3-4,10-17H2
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0.288n/an/an/an/an/an/an/an/a



Solvay Pharma

Curated by ChEMBL


Assay Description
Inhibition of [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor of rat frontal cortex membranes


Bioorg Med Chem Lett 8: 2457-62 (1999)


Article DOI: 10.1016/s0960-894x(98)00406-5
BindingDB Entry DOI: 10.7270/Q2KS6SQ1
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50263290
PNG
(2-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]th...)
Show SMILES COc1ccccc1N1CCN(CCCSc2nc3ccccc3s2)CC1
Show InChI InChI=1S/C21H25N3OS2/c1-25-19-9-4-3-8-18(19)24-14-12-23(13-15-24)11-6-16-26-21-22-17-7-2-5-10-20(17)27-21/h2-5,7-10H,6,11-16H2,1H3
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0.290n/an/an/an/an/an/an/an/a



Università di Catania

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT from 5HT1A receptor in CRL:CD(SD)BR-COBS rat hippocampus


J Med Chem 51: 4529-38 (2008)


Article DOI: 10.1021/jm800176x
BindingDB Entry DOI: 10.7270/Q2Q81CWG
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50346375
PNG
(4-[3-[4-(naphthalen)piperazin-1-yl]propoxy]-4-aza-...)
Show SMILES O=C1C2C3CC(C=C3)C2C(=O)N1OCCCN1CCN(CC1)c1cccc2ccccc12
Show InChI InChI=1S/C26H29N3O3/c30-25-23-19-9-10-20(17-19)24(23)26(31)29(25)32-16-4-11-27-12-14-28(15-13-27)22-8-3-6-18-5-1-2-7-21(18)22/h1-3,5-10,19-20,23-24H,4,11-17H2
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0.293n/an/an/an/an/an/an/an/a



Universit£ di Napoli Federico II

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT from 5HT1A receptor in Sprague-Dawley rat brain cortex homogenates after 30 mins by liquid scintillation counting


Eur J Med Chem 46: 2206-16 (2011)


Article DOI: 10.1016/j.ejmech.2011.03.001
BindingDB Entry DOI: 10.7270/Q2M32W4J
More data for this
Ligand-Target Pair
Serotonin 1 (5-HT1) receptor


(Rattus norvegicus (rat))
BDBM50039824
PNG
(CHEMBL81728 | N-{2-[4-(2,3-Dihydro-benzo[1,4]dioxi...)
Show SMILES Fc1ccc(cc1)C(=O)NCCN1CCN(CC1)c1cccc2OCCOc12
Show InChI InChI=1S/C21H24FN3O3/c22-17-6-4-16(5-7-17)21(26)23-8-9-24-10-12-25(13-11-24)18-2-1-3-19-20(18)28-15-14-27-19/h1-7H,8-15H2,(H,23,26)
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0.295n/an/an/an/an/an/an/an/a



Solvay Pharma

Curated by ChEMBL


Assay Description
Inhibition of [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor of rat frontal cortex membranes


Bioorg Med Chem Lett 8: 2457-62 (1999)


Article DOI: 10.1016/s0960-894x(98)00406-5
BindingDB Entry DOI: 10.7270/Q2KS6SQ1
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50039824
PNG
(CHEMBL81728 | N-{2-[4-(2,3-Dihydro-benzo[1,4]dioxi...)
Show SMILES Fc1ccc(cc1)C(=O)NCCN1CCN(CC1)c1cccc2OCCOc12
Show InChI InChI=1S/C21H24FN3O3/c22-17-6-4-16(5-7-17)21(26)23-8-9-24-10-12-25(13-11-24)18-2-1-3-19-20(18)28-15-14-27-19/h1-7H,8-15H2,(H,23,26)
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0.300n/an/an/an/an/an/an/an/a



Solvay Duphar Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to displace [3H]2-(di-N-propylamino)-8-hydroxy-tetralin from 5-hydroxytryptamine 1A (5-HT1A) receptor in rat frontal cortex homogena...


J Med Chem 37: 2761-73 (1994)


Article DOI: 10.1021/jm00043a015
BindingDB Entry DOI: 10.7270/Q2DJ5G84
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50035347
PNG
(8-(Allyl-propyl-amino)-6,7,8,9-tetrahydro-3H-benzo...)
Show SMILES CCCN(CC=C)C1CCc2ccc3[nH]cc(C=O)c3c2C1
Show InChI InChI=1S/C19H24N2O/c1-3-9-21(10-4-2)16-7-5-14-6-8-18-19(17(14)11-16)15(13-22)12-20-18/h3,6,8,12-13,16,20H,1,4-5,7,9-11H2,2H3
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0.300n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1A receptor expressed in CHO cells, by using [3H]8-OH-DPAT as radioligand.


J Med Chem 38: 2217-30 (1995)


Article DOI: 10.1021/jm00012a022
BindingDB Entry DOI: 10.7270/Q28G8MBW
More data for this
Ligand-Target Pair
Serotonin 1 (5-HT1) receptor


(Rattus norvegicus (rat))
BDBM50041469
PNG
((R,S) 7-[(3-Iodo-allyl)-propyl-amino]-5,6,7,8-tetr...)
Show SMILES CCCN(C\C=C\I)C1CCc2cccc(O)c2C1
Show InChI InChI=1S/C16H22INO/c1-2-10-18(11-4-9-17)14-8-7-13-5-3-6-16(19)15(13)12-14/h3-6,9,14,19H,2,7-8,10-12H2,1H3/b9-4+
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0.300n/an/an/an/an/an/an/an/a



University of Pennsylvania

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 1A receptor by the displacement of [125I]trans-8-OH-PIPAT in membrane homogenates of hippocampal tissue ...


J Med Chem 36: 3161-5 (1993)


Article DOI: 10.1021/jm00073a016
BindingDB Entry DOI: 10.7270/Q2JQ11N4
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50061646
PNG
(2-{[3-(3-Methyl-benzo[d]isoxazol-6-yloxy)-propylam...)
Show SMILES Cc1noc2cc(OCCCNCC3CCc4ccc(O)cc4O3)ccc12
Show InChI InChI=1S/C21H24N2O4/c1-14-19-8-7-17(12-21(19)27-23-14)25-10-2-9-22-13-18-6-4-15-3-5-16(24)11-20(15)26-18/h3,5,7-8,11-12,18,22,24H,2,4,6,9-10,13H2,1H3
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0.300n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity to rat hippocampal 5-hydroxytryptamine 1A receptor was determined using [3H]8-OH-DPAT as radioligand


J Med Chem 40: 4235-56 (1998)


Article DOI: 10.1021/jm9703653
BindingDB Entry DOI: 10.7270/Q2KP82TD
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50035335
PNG
((R)-8-Dipropylamino-4-fluoro-6,7,8,9-tetrahydro-3H...)
Show SMILES CCCN(CCC)[C@@H]1CCc2cc(F)c3[nH]cc(C=O)c3c2C1
Show InChI InChI=1S/C19H25FN2O/c1-3-7-22(8-4-2)15-6-5-13-9-17(20)19-18(16(13)10-15)14(12-23)11-21-19/h9,11-12,15,21H,3-8,10H2,1-2H3/t15-/m1/s1
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0.300n/an/an/an/an/an/an/an/a



Göteborg University

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor from CHO-K1 cells, using [3H]-8-OH-DPAT as the radioligand.


J Med Chem 38: 2202-16 (1995)


Article DOI: 10.1021/jm00012a021
BindingDB Entry DOI: 10.7270/Q24T6HD0
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50090771
PNG
((R)-1-[3-(Isopropyl-propyl-amino)-chroman-5-yl]-et...)
Show SMILES CCCN(C(C)C)C1COc2cccc(C(C)=O)c2C1
Show InChI InChI=1S/C17H25NO2/c1-5-9-18(12(2)3)14-10-16-15(13(4)19)7-6-8-17(16)20-11-14/h6-8,12,14H,5,9-11H2,1-4H3
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0.300n/an/an/an/an/an/an/an/a



AstraZeneca R&D Södertälje

Curated by ChEMBL


Assay Description
In vitro binding affinity at 5-HT1A receptors assayed by displacement of [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor in rat hippocampal membr...


J Med Chem 43: 2837-50 (2000)


Article DOI: 10.1021/jm990956o
BindingDB Entry DOI: 10.7270/Q2610ZJK
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM29563
PNG
(1-(m-trifluorophenyl)piperazine, 10)
Show SMILES FC(F)(F)c1cccc(c1)N1CCN(CC1)C1CCC(CC1)N1C(=O)C2=C(CCCC2)C1=O
Show InChI InChI=1S/C25H30F3N3O2/c26-25(27,28)17-4-3-5-20(16-17)30-14-12-29(13-15-30)18-8-10-19(11-9-18)31-23(32)21-6-1-2-7-22(21)24(31)33/h3-5,16,18-19H,1-2,6-15H2
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0.300 -56.5n/an/an/an/an/a7.437



Polish Academy of Science



Assay Description
Competition experiments were performed in the presence radioligand with membrane protein and test compounds. After incubation, the reaction stopped b...


Bioorg Med Chem 15: 7116-25 (2007)


Article DOI: 10.1016/j.bmc.2007.07.029
BindingDB Entry DOI: 10.7270/Q2G15Z6G
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM82517
PNG
(2-{4-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-butyl}-...)
Show SMILES COc1ccccc1N1CCN(CCCCN2C(=O)c3ccccc3C2=O)CC1
Show InChI InChI=1S/C23H27N3O3/c1-29-21-11-5-4-10-20(21)25-16-14-24(15-17-25)12-6-7-13-26-22(27)18-8-2-3-9-19(18)23(26)28/h2-5,8-11H,6-7,12-17H2,1H3
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0.300n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by PDSP Ki Database




Neuron 11: 449-58 (1993)


BindingDB Entry DOI: 10.7270/Q269723D
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50039824
PNG
(CHEMBL81728 | N-{2-[4-(2,3-Dihydro-benzo[1,4]dioxi...)
Show SMILES Fc1ccc(cc1)C(=O)NCCN1CCN(CC1)c1cccc2OCCOc12
Show InChI InChI=1S/C21H24FN3O3/c22-17-6-4-16(5-7-17)21(26)23-8-9-24-10-12-25(13-11-24)18-2-1-3-19-20(18)28-15-14-27-19/h1-7H,8-15H2,(H,23,26)
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0.300n/an/an/an/an/an/an/an/a



Solvay Pharma

Curated by ChEMBL


Assay Description
Binding affinity was evaluated by determining in vitro displacement of [3H]-8-OH-DPAT from the central 5-hydroxytryptamine 1A receptor recognition si...


J Med Chem 40: 300-12 (1997)


Article DOI: 10.1021/jm960496o
BindingDB Entry DOI: 10.7270/Q27W6B96
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50033843
PNG
(1-[3-(5-Methoxy-3,4-dihydro-2H-naphthalen-1-yliden...)
Show SMILES COc1cccc2\C(CCCc12)=C\CCN1CCN(CC1)c1ccccn1
Show InChI InChI=1S/C23H29N3O/c1-27-22-11-5-9-20-19(7-4-10-21(20)22)8-6-14-25-15-17-26(18-16-25)23-12-2-3-13-24-23/h2-3,5,8-9,11-13H,4,6-7,10,14-18H2,1H3/b19-8+
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0.310n/an/an/an/an/an/an/an/a



Università Bari

Curated by ChEMBL


Assay Description
Binding was determined on 5-hydroxytryptamine 1A receptor in rat hippocampal membranes


J Med Chem 44: 4431-42 (2001)


Article DOI: 10.1021/jm010866v
BindingDB Entry DOI: 10.7270/Q2NC60GV
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50039818
PNG
(1-(2,3-Dihydro-benzo[1,4]dioxin-5-yl)-4-(4-phenyl-...)
Show SMILES C(CCc1ccccc1)CN1CCN(CC1)c1cccc2OCCOc12
Show InChI InChI=1S/C22H28N2O2/c1-2-7-19(8-3-1)9-4-5-12-23-13-15-24(16-14-23)20-10-6-11-21-22(20)26-18-17-25-21/h1-3,6-8,10-11H,4-5,9,12-18H2
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0.320n/an/an/an/an/an/an/an/a



Solvay Duphar Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to displace [3H]2-(di-N-propylamino)-8-hydroxy-tetralin from 5-hydroxytryptamine 1A (5-HT1A) receptor in rat frontal cortex homogena...


J Med Chem 37: 2761-73 (1994)


Article DOI: 10.1021/jm00043a015
BindingDB Entry DOI: 10.7270/Q2DJ5G84
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50056040
PNG
(CHEMBL107141 | Cyclohexanecarbothioic acid {2-[4-(...)
Show SMILES COc1ccccc1N1CCN(CCNC(=S)C2CCCCC2)CC1
Show InChI InChI=1S/C20H31N3OS/c1-24-19-10-6-5-9-18(19)23-15-13-22(14-16-23)12-11-21-20(25)17-7-3-2-4-8-17/h5-6,9-10,17H,2-4,7-8,11-16H2,1H3,(H,21,25)
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0.320n/an/an/an/an/an/an/an/a



Solvay Pharma

Curated by ChEMBL


Assay Description
Binding affinity was evaluated by determining in vitro displacement of [3H]-8-OH-DPAT from the central 5-hydroxytryptamine 1A receptor recognition si...


J Med Chem 40: 300-12 (1997)


Article DOI: 10.1021/jm960496o
BindingDB Entry DOI: 10.7270/Q27W6B96
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50033872
PNG
((6aR,9R)-7-Methyl-4,6,6a,7,8,9-hexahydro-indolo[4,...)
Show SMILES CCCC[C@@H](C)NC(=O)[C@H]1CN(C)[C@@H]2Cc3c[nH]c4cccc(C2=C1)c34
Show InChI InChI=1S/C22H29N3O/c1-4-5-7-14(2)24-22(26)16-10-18-17-8-6-9-19-21(17)15(12-23-19)11-20(18)25(3)13-16/h6,8-10,12,14,16,20,23H,4-5,7,11,13H2,1-3H3,(H,24,26)/t14-,16-,20-/m1/s1
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0.320n/an/an/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Binding affinity was measured against 5-hydroxytryptamine 1A receptor by displacement of [3H]-8-OH-DPAT by lysergic acid amides


J Med Chem 38: 958-66 (1995)


Article DOI: 10.1021/jm00006a015
BindingDB Entry DOI: 10.7270/Q2NZ86N6
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50090762
PNG
((R)-3-(Isopropyl-propyl-amino)-chroman-5-carboxyli...)
Show SMILES CCCN(C(C)C)C1COc2cccc(C(=O)OC)c2C1
Show InChI InChI=1S/C17H25NO3/c1-5-9-18(12(2)3)13-10-15-14(17(19)20-4)7-6-8-16(15)21-11-13/h6-8,12-13H,5,9-11H2,1-4H3
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0.320n/an/an/an/an/an/an/an/a



AstraZeneca R&D Södertälje

Curated by ChEMBL


Assay Description
In vitro binding affinity at 5-HT1A receptors assayed by displacement of [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor in rat hippocampal membr...


J Med Chem 43: 2837-50 (2000)


Article DOI: 10.1021/jm990956o
BindingDB Entry DOI: 10.7270/Q2610ZJK
More data for this
Ligand-Target Pair
Serotonin 1 (5-HT1) receptor


(Rattus norvegicus (rat))
BDBM50039818
PNG
(1-(2,3-Dihydro-benzo[1,4]dioxin-5-yl)-4-(4-phenyl-...)
Show SMILES C(CCc1ccccc1)CN1CCN(CC1)c1cccc2OCCOc12
Show InChI InChI=1S/C22H28N2O2/c1-2-7-19(8-3-1)9-4-5-12-23-13-15-24(16-14-23)20-10-6-11-21-22(20)26-18-17-25-21/h1-3,6-8,10-11H,4-5,9,12-18H2
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0.324n/an/an/an/an/an/an/an/a



Solvay Pharma

Curated by ChEMBL


Assay Description
Inhibition of [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor of rat frontal cortex membranes


Bioorg Med Chem Lett 8: 2457-62 (1999)


Article DOI: 10.1016/s0960-894x(98)00406-5
BindingDB Entry DOI: 10.7270/Q2KS6SQ1
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50064537
PNG
(CHEMBL293658 | {3-[4-(2,3-Dihydro-benzo[1,4]dioxin...)
Show SMILES O=C(N1CCCCC1)c1cccc(CN2CCN(CC2)C2COc3ccccc3O2)c1
Show InChI InChI=1S/C25H31N3O3/c29-25(28-11-4-1-5-12-28)21-8-6-7-20(17-21)18-26-13-15-27(16-14-26)24-19-30-22-9-2-3-10-23(22)31-24/h2-3,6-10,17,24H,1,4-5,11-16,18-19H2
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0.340n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Compound was evaluated for its binding affinity against 5-hydroxytryptamine 1A receptor from rat cerebral cortex


J Med Chem 41: 1997-2009 (1998)


Article DOI: 10.1021/jm970164z
BindingDB Entry DOI: 10.7270/Q2KK9CG0
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50090763
PNG
((R)-3-{[4-(7,9-Dioxo-8-aza-spiro[4.5]dec-8-yl)-but...)
Show SMILES CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(C(=O)NC)c2C1
Show InChI InChI=1S/C27H39N3O4/c1-3-13-29(20-16-22-21(26(33)28-2)9-8-10-23(22)34-19-20)14-6-7-15-30-24(31)17-27(18-25(30)32)11-4-5-12-27/h8-10,20H,3-7,11-19H2,1-2H3,(H,28,33)
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0.340n/an/an/an/an/an/an/an/a



AstraZeneca R&D Södertälje

Curated by ChEMBL


Assay Description
In vitro binding affinity at 5-HT1A receptors assayed by displacement of [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor in rat hippocampal membr...


J Med Chem 43: 2837-50 (2000)


Article DOI: 10.1021/jm990956o
BindingDB Entry DOI: 10.7270/Q2610ZJK
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50062273
PNG
(3-Hydroxy-2-{2-[4-(2-methoxy-phenyl)-piperazin-1-y...)
Show SMILES COc1ccccc1N1CCN(CCN2C(=O)c3cc(ccc3C2(O)c2ccccc2)[N+]([O-])=O)CC1
Show InChI InChI=1S/C27H28N4O5/c1-36-25-10-6-5-9-24(25)29-16-13-28(14-17-29)15-18-30-26(32)22-19-21(31(34)35)11-12-23(22)27(30,33)20-7-3-2-4-8-20/h2-12,19,33H,13-18H2,1H3
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0.340n/an/an/an/an/an/an/an/a



University of Pennsylvania

Curated by ChEMBL


Assay Description
In vitro binding affinity for 5-hydroxytryptamine 1A receptor in rat hippocampal membranes by [125I]-labeled agonist displacement.


J Med Chem 41: 157-66 (1998)


Article DOI: 10.1021/jm970296s
BindingDB Entry DOI: 10.7270/Q2TX3DH6
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50057429
PNG
(CHEMBL22328 | [2-(7-Fluoro-chroman-8-yloxy)-ethyl]...)
Show SMILES COc1ccc(CCCCNCCOc2c(F)ccc3CCCOc23)cc1
Show InChI InChI=1S/C22H28FNO3/c1-25-19-10-7-17(8-11-19)5-2-3-13-24-14-16-27-22-20(23)12-9-18-6-4-15-26-21(18)22/h7-12,24H,2-6,13-16H2,1H3
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0.350n/an/an/an/an/an/an/an/a



Yamanouchi Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT from rat hippocampal 5-hydroxytryptamine 1A receptor


J Med Chem 40: 1252-7 (1997)


Article DOI: 10.1021/jm960760d
BindingDB Entry DOI: 10.7270/Q20R9Q26
More data for this
Ligand-Target Pair
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