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Compile Data Set for Download or QSAR

Found 1380 hits Enz. Inhib. hit(s) with Target = 'sodium-dependent glucose cotransporter 2 (SGLT2)' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM20878
PNG
((2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-{2-[(4-methox...)
Show SMILES COc1ccc(Cc2ccccc2O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C20H24O7/c1-25-14-8-6-12(7-9-14)10-13-4-2-3-5-15(13)26-20-19(24)18(23)17(22)16(11-21)27-20/h2-9,16-24H,10-11H2,1H3/t16-,17-,18+,19-,20-/m1/s1
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2.40n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Co

Curated by ChEMBL


Assay Description
Inhibition of human kidney SGLT2 assessed as renal glucose reabsorption


Citation and Details
More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM20878
PNG
((2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-{2-[(4-methox...)
Show SMILES COc1ccc(Cc2ccccc2O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C20H24O7/c1-25-14-8-6-12(7-9-14)10-13-4-2-3-5-15(13)26-20-19(24)18(23)17(22)16(11-21)27-20/h2-9,16-24H,10-11H2,1H3/t16-,17-,18+,19-,20-/m1/s1
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2.40n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Co

Curated by ChEMBL


Assay Description
Inhibition of human kidney SGLT2 assessed as renal glucose reabsorption


Citation and Details
More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM20877
PNG
(3-(1-benzofuran-5-yl)-1-(2-hydroxy-4-methyl-6-{[(2...)
Show SMILES Cc1cc(O)c(C(=O)CCc2ccc3occc3c2)c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1
Show InChI InChI=1S/C24H26O9/c1-12-8-16(27)20(15(26)4-2-13-3-5-17-14(10-13)6-7-31-17)18(9-12)32-24-23(30)22(29)21(28)19(11-25)33-24/h3,5-10,19,21-25,27-30H,2,4,11H2,1H3/t19-,21-,22+,23-,24-/m1/s1
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4n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2


Citation and Details
More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM50153302
PNG
(3-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-1-[2-hydroxy...)
Show SMILES Cc1cc(O)c(C(=O)CCc2ccc3OCCOc3c2)c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1
Show InChI InChI=1S/C24H28O10/c1-12-8-15(27)20(14(26)4-2-13-3-5-16-17(10-13)32-7-6-31-16)18(9-12)33-24-23(30)22(29)21(28)19(11-25)34-24/h3,5,8-10,19,21-25,27-30H,2,4,6-7,11H2,1H3/t19-,21-,22+,23-,24-/m1/s1
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9n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2


Citation and Details
More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM50153301
PNG
(3-(4-Ethoxy-phenyl)-1-[2-hydroxy-4-methyl-6-(3,4,5...)
Show SMILES CCOc1ccc(CCC(=O)c2c(O)cc(C)cc2O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C24H30O9/c1-3-31-15-7-4-14(5-8-15)6-9-16(26)20-17(27)10-13(2)11-18(20)32-24-23(30)22(29)21(28)19(12-25)33-24/h4-5,7-8,10-11,19,21-25,27-30H,3,6,9,12H2,1-2H3/t19-,21-,22+,23-,24-/m1/s1
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10n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2


Citation and Details
More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM50153298
PNG
(3-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-1-[4-ethyl-2...)
Show SMILES CCc1cc(O)c(C(=O)CCc2ccc3OCCOc3c2)c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1
Show InChI InChI=1S/C25H30O10/c1-2-13-9-16(28)21(15(27)5-3-14-4-6-17-18(11-14)33-8-7-32-17)19(10-13)34-25-24(31)23(30)22(29)20(12-26)35-25/h4,6,9-11,20,22-26,28-31H,2-3,5,7-8,12H2,1H3/t20-,22-,23+,24-,25-/m1/s1
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10n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2


Citation and Details
More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM50153312
PNG
(1-[2-Hydroxy-4-methyl-6-(3,4,5-trihydroxy-6-hydrox...)
Show SMILES Cc1cc(O)c(C(=O)CCc2ccc3ccccc3c2)c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1
Show InChI InChI=1S/C26H28O8/c1-14-10-19(29)22(18(28)9-7-15-6-8-16-4-2-3-5-17(16)12-15)20(11-14)33-26-25(32)24(31)23(30)21(13-27)34-26/h2-6,8,10-12,21,23-27,29-32H,7,9,13H2,1H3/t21-,23-,24+,25-,26-/m1/s1
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10n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2


Citation and Details
More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM50153305
PNG
(1-[4-Ethyl-2-hydroxy-6-(3,4,5-trihydroxy-6-hydroxy...)
Show SMILES CCc1cc(O)c(C(=O)CCc2ccc3ccccc3c2)c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1
Show InChI InChI=1S/C27H30O8/c1-2-15-12-20(30)23(19(29)10-8-16-7-9-17-5-3-4-6-18(17)11-16)21(13-15)34-27-26(33)25(32)24(31)22(14-28)35-27/h3-7,9,11-13,22,24-28,30-33H,2,8,10,14H2,1H3/t22-,24-,25+,26-,27-/m1/s1
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10n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2


Citation and Details
More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM50257747
PNG
(CHEMBL494322 | remogliflozin)
Show SMILES CC(C)Oc1ccc(CC(=O)c2c(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)[nH]nc2C(C)C)cc1
Show InChI InChI=1S/C23H32N2O8/c1-11(2)18-17(15(27)9-13-5-7-14(8-6-13)31-12(3)4)22(25-24-18)33-23-21(30)20(29)19(28)16(10-26)32-23/h5-8,11-12,16,19-21,23,26,28-30H,9-10H2,1-4H3,(H,24,25)/t16-,19-,20+,21-,23+/m1/s1
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12n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Co

Curated by ChEMBL


Assay Description
Inhibition of human kidney SGLT2 assessed as renal glucose reabsorption


Citation and Details
More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM50257747
PNG
(CHEMBL494322 | remogliflozin)
Show SMILES CC(C)Oc1ccc(CC(=O)c2c(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)[nH]nc2C(C)C)cc1
Show InChI InChI=1S/C23H32N2O8/c1-11(2)18-17(15(27)9-13-5-7-14(8-6-13)31-12(3)4)22(25-24-18)33-23-21(30)20(29)19(28)16(10-26)32-23/h5-8,11-12,16,19-21,23,26,28-30H,9-10H2,1-4H3,(H,24,25)/t16-,19-,20+,21-,23+/m1/s1
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12n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Co

Curated by ChEMBL


Assay Description
Inhibition of human kidney SGLT2 assessed as renal glucose reabsorption


Citation and Details
More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM20875
PNG
(1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihyd...)
Show SMILES OC[C@H]1O[C@@H](Oc2cc(O)cc(O)c2C(=O)CCc2ccc(O)cc2)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C21H24O10/c22-9-16-18(27)19(28)20(29)21(31-16)30-15-8-12(24)7-14(26)17(15)13(25)6-3-10-1-4-11(23)5-2-10/h1-2,4-5,7-8,16,18-24,26-29H,3,6,9H2/t16-,18-,19+,20-,21-/m1/s1
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19n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Co

Curated by ChEMBL


Assay Description
Inhibition of human kidney SGLT2 assessed as renal glucose reabsorption


Citation and Details
More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM50153309
PNG
(3-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-1-[2-hydroxy...)
Show SMILES CC(C)c1cc(O)c(C(=O)CCc2ccc3OCCOc3c2)c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1
Show InChI InChI=1S/C26H32O10/c1-13(2)15-10-17(29)22(16(28)5-3-14-4-6-18-19(9-14)34-8-7-33-18)20(11-15)35-26-25(32)24(31)23(30)21(12-27)36-26/h4,6,9-11,13,21,23-27,29-32H,3,5,7-8,12H2,1-2H3/t21-,23-,24+,25-,26-/m1/s1
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20n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2


Citation and Details
More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM50153293
PNG
(1-[4-Chloro-2-hydroxy-6-(3,4,5-trihydroxy-6-hydrox...)
Show SMILES OC[C@H]1O[C@@H](Oc2cc(Cl)cc(O)c2C(=O)CCc2ccc3OCCOc3c2)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C23H25ClO10/c24-12-8-14(27)19(13(26)3-1-11-2-4-15-16(7-11)32-6-5-31-15)17(9-12)33-23-22(30)21(29)20(28)18(10-25)34-23/h2,4,7-9,18,20-23,25,27-30H,1,3,5-6,10H2/t18-,20-,21+,22-,23-/m1/s1
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20n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2


Citation and Details
More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM50153296
PNG
(1-[4-Chloro-2-hydroxy-6-(3,4,5-trihydroxy-6-hydrox...)
Show SMILES OC[C@H]1O[C@@H](Oc2cc(Cl)cc(O)c2C(=O)CCc2ccc3ccccc3c2)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C25H25ClO8/c26-16-10-18(29)21(17(28)8-6-13-5-7-14-3-1-2-4-15(14)9-13)19(11-16)33-25-24(32)23(31)22(30)20(12-27)34-25/h1-5,7,9-11,20,22-25,27,29-32H,6,8,12H2/t20-,22-,23+,24-,25-/m1/s1
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30n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2


Citation and Details
More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM50153294
PNG
(3-(4-Ethoxy-phenyl)-1-[4-ethyl-2-hydroxy-6-(3,4,5-...)
Show SMILES CCOc1ccc(CCC(=O)c2c(O)cc(CC)cc2O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C25H32O9/c1-3-14-11-18(28)21(17(27)10-7-15-5-8-16(9-6-15)32-4-2)19(12-14)33-25-24(31)23(30)22(29)20(13-26)34-25/h5-6,8-9,11-12,20,22-26,28-31H,3-4,7,10,13H2,1-2H3/t20-,22-,23+,24-,25-/m1/s1
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30n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2


Citation and Details
More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM50153313
PNG
(3-Cyclohexyl-1-[2-hydroxy-4-methyl-6-(3,4,5-trihyd...)
Show SMILES Cc1cc(O)c(C(=O)CCC2CCCCC2)c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1
Show InChI InChI=1S/C22H32O8/c1-12-9-15(25)18(14(24)8-7-13-5-3-2-4-6-13)16(10-12)29-22-21(28)20(27)19(26)17(11-23)30-22/h9-10,13,17,19-23,25-28H,2-8,11H2,1H3/t17-,19-,20+,21-,22-/m1/s1
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40n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2


Citation and Details
More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM50153306
PNG
(1-[2-Hydroxy-4-methyl-6-(3,4,5-trihydroxy-6-hydrox...)
Show SMILES Cc1cc(O)c(C(=O)CCc2ccsc2)c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1
Show InChI InChI=1S/C20H24O8S/c1-10-6-13(23)16(12(22)3-2-11-4-5-29-9-11)14(7-10)27-20-19(26)18(25)17(24)15(8-21)28-20/h4-7,9,15,17-21,23-26H,2-3,8H2,1H3/t15-,17-,18+,19-,20-/m1/s1
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70n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2


Citation and Details
More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM50153292
PNG
(1-[4-Fluoro-2-hydroxy-6-(3,4,5-trihydroxy-6-hydrox...)
Show SMILES OC[C@H]1O[C@@H](Oc2cc(F)cc(O)c2C(=O)CCc2ccc3ccccc3c2)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C25H25FO8/c26-16-10-18(29)21(17(28)8-6-13-5-7-14-3-1-2-4-15(14)9-13)19(11-16)33-25-24(32)23(31)22(30)20(12-27)34-25/h1-5,7,9-11,20,22-25,27,29-32H,6,8,12H2/t20-,22-,23+,24-,25-/m1/s1
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70n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2


Citation and Details
More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM50153299
PNG
(1-[4-Chloro-2-hydroxy-6-(3,4,5-trihydroxy-6-hydrox...)
Show SMILES CCOc1ccc(CCC(=O)c2c(O)cc(Cl)cc2O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C23H27ClO9/c1-2-31-14-6-3-12(4-7-14)5-8-15(26)19-16(27)9-13(24)10-17(19)32-23-22(30)21(29)20(28)18(11-25)33-23/h3-4,6-7,9-10,18,20-23,25,27-30H,2,5,8,11H2,1H3/t18-,20-,21+,22-,23-/m1/s1
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80n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2


Citation and Details
More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM50153304
PNG
(3-(4-Ethoxy-phenyl)-1-[2-hydroxy-4-isopropyl-6-(3,...)
Show SMILES CCOc1ccc(CCC(=O)c2c(O)cc(cc2O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)C(C)C)cc1
Show InChI InChI=1S/C26H34O9/c1-4-33-17-8-5-15(6-9-17)7-10-18(28)22-19(29)11-16(14(2)3)12-20(22)34-26-25(32)24(31)23(30)21(13-27)35-26/h5-6,8-9,11-12,14,21,23-27,29-32H,4,7,10,13H2,1-3H3/t21-,23-,24+,25-,26-/m1/s1
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110n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2


Citation and Details
More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM50153307
PNG
(1-[2-Hydroxy-4-isopropyl-6-(3,4,5-trihydroxy-6-hyd...)
Show SMILES CC(C)c1cc(O)c(C(=O)CCc2ccc3ccccc3c2)c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1
Show InChI InChI=1S/C28H32O8/c1-15(2)19-12-21(31)24(20(30)10-8-16-7-9-17-5-3-4-6-18(17)11-16)22(13-19)35-28-27(34)26(33)25(32)23(14-29)36-28/h3-7,9,11-13,15,23,25-29,31-34H,8,10,14H2,1-2H3/t23-,25-,26+,27-,28-/m1/s1
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150n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2


Citation and Details
More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM50153303
PNG
(3-Furan-3-yl-1-[2-hydroxy-4-methyl-6-(3,4,5-trihyd...)
Show SMILES Cc1cc(O)c(C(=O)CCc2ccoc2)c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1
Show InChI InChI=1S/C20H24O9/c1-10-6-13(23)16(12(22)3-2-11-4-5-27-9-11)14(7-10)28-20-19(26)18(25)17(24)15(8-21)29-20/h4-7,9,15,17-21,23-26H,2-3,8H2,1H3/t15-,17-,18+,19-,20-/m1/s1
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230n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2


Citation and Details
More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM50153311
PNG
(1-[2-Amino-4-methyl-6-(3,4,5-trihydroxy-6-hydroxym...)
Show SMILES Cc1cc(N)c(C(=O)CCc2ccc3OCCOc3c2)c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1
Show InChI InChI=1S/C24H29NO9/c1-12-8-14(25)20(15(27)4-2-13-3-5-16-17(10-13)32-7-6-31-16)18(9-12)33-24-23(30)22(29)21(28)19(11-26)34-24/h3,5,8-10,19,21-24,26,28-30H,2,4,6-7,11,25H2,1H3/t19-,21-,22+,23-,24-/m1/s1
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290n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2


Citation and Details
More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM50153308
PNG
(1-[2-Amino-4-methyl-6-(3,4,5-trihydroxy-6-hydroxym...)
Show SMILES Cc1cc(N)c(C(=O)CCc2ccc3ccccc3c2)c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1
Show InChI InChI=1S/C26H29NO7/c1-14-10-18(27)22(19(29)9-7-15-6-8-16-4-2-3-5-17(16)12-15)20(11-14)33-26-25(32)24(31)23(30)21(13-28)34-26/h2-6,8,10-12,21,23-26,28,30-32H,7,9,13,27H2,1H3/t21-,23-,24+,25-,26-/m1/s1
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520n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2


Citation and Details
More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM50153297
PNG
(1-[2-Amino-4-methyl-6-(3,4,5-trihydroxy-6-hydroxym...)
Show SMILES CCOc1ccc(CCC(=O)c2c(N)cc(C)cc2O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C24H31NO8/c1-3-31-15-7-4-14(5-8-15)6-9-17(27)20-16(25)10-13(2)11-18(20)32-24-23(30)22(29)21(28)19(12-26)33-24/h4-5,7-8,10-11,19,21-24,26,28-30H,3,6,9,12,25H2,1-2H3/t19-,21-,22+,23-,24-/m1/s1
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1.28E+3n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2


Citation and Details
More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM50153310
PNG
(1-[2-Chloro-6-(3,4,5-trihydroxy-6-hydroxymethyl-te...)
Show SMILES OC[C@H]1O[C@@H](Oc2cccc(Cl)c2C(=O)CCc2ccc3ccccc3c2)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C25H25ClO7/c26-17-6-3-7-19(32-25-24(31)23(30)22(29)20(13-27)33-25)21(17)18(28)11-9-14-8-10-15-4-1-2-5-16(15)12-14/h1-8,10,12,20,22-25,27,29-31H,9,11,13H2/t20-,22-,23+,24-,25-/m1/s1
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>1.70E+3n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2


Citation and Details
More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM50153295
PNG
(1-[2-Chloro-6-(3,4,5-trihydroxy-6-hydroxymethyl-te...)
Show SMILES OC[C@H]1O[C@@H](Oc2cccc(Cl)c2C(=O)CCc2ccc3OCCOc3c2)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C23H25ClO9/c24-13-2-1-3-16(32-23-22(29)21(28)20(27)18(11-25)33-23)19(13)14(26)6-4-12-5-7-15-17(10-12)31-9-8-30-15/h1-3,5,7,10,18,20-23,25,27-29H,4,6,8-9,11H2/t18-,20-,21+,22-,23-/m1/s1
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>1.70E+3n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2


Citation and Details
More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM50153300
PNG
(1-[2-Chloro-6-(3,4,5-trihydroxy-6-hydroxymethyl-te...)
Show SMILES CCOc1ccc(CCC(=O)c2c(Cl)cccc2O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C23H27ClO8/c1-2-30-14-9-6-13(7-10-14)8-11-16(26)19-15(24)4-3-5-17(19)31-23-22(29)21(28)20(27)18(12-25)32-23/h3-7,9-10,18,20-23,25,27-29H,2,8,11-12H2,1H3/t18-,20-,21+,22-,23-/m1/s1
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>1.70E+3n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2


Citation and Details
More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM50303246
PNG
((1S,3'R,4'S,5'S,6'R)-5-chloro-6'-(hydroxymethyl)-6...)
Show SMILES OC[C@H]1O[C@]2(OCc3cc(Cl)c(Cc4ccc(OC(F)(F)F)cc4)cc23)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C21H20ClF3O7/c22-15-7-12-9-30-20(19(29)18(28)17(27)16(8-26)32-20)14(12)6-11(15)5-10-1-3-13(4-2-10)31-21(23,24)25/h1-4,6-7,16-19,26-29H,5,8-9H2/t16-,17-,18+,19-,20+/m1/s1
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n/an/a 0.300n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 transfected in HEK293.ETN cells assessed as AMG uptake after 1.5 hrs by scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM50321299
PNG
((2S,3R,4R,5S,6R)-2-(4-chloro-5-(4-ethylbenzyl)-2-(...)
Show SMILES CCc1ccc(Cc2cc([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)c(COCC#C)cc2Cl)cc1
Show InChI InChI=1S/C25H29ClO6/c1-3-9-31-14-18-12-20(26)17(10-16-7-5-15(4-2)6-8-16)11-19(18)25-24(30)23(29)22(28)21(13-27)32-25/h1,5-8,11-12,21-25,27-30H,4,9-10,13-14H2,2H3/t21-,22-,23+,24-,25+/m1/s1
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n/an/a 0.300n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in HEK293 cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside uptake after 1.5 hrs by liquid sci...


Citation and Details
More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM159472
PNG
(US9034921, E114)
Show SMILES CCOc1ccc(Cc2cc(cc(OC)c2Cl)[C@@H]2O[C@H](SC)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1/C22H27ClO6S/c1-4-28-15-7-5-12(6-8-15)9-13-10-14(11-16(27-2)17(13)23)21-19(25)18(24)20(26)22(29-21)30-3/h5-8,10-11,18-22,24-26H,4,9H2,1-3H3/t18-,19-,20+,21+,22-/s2
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n/an/a 0.308n/an/an/an/an/an/a



GREEN CROSS CORPORATION

US Patent


Assay Description
For sodium-dependent glucose transport assay, cells expressing hSGLT2 were seeded into a 96-well culture plate at a density of 5x104 cells/well in RP...


US Patent US9034921 (2015)

More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM159516
PNG
(US9034921, E158)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1cc(Cc2ccc(cc2)C2CC2)c(Cl)c2OCOc12
Show InChI InChI=1/C23H25ClO7/c24-17-14(7-11-1-3-12(4-2-11)13-5-6-13)8-15(22-23(17)30-10-29-22)21-20(28)19(27)18(26)16(9-25)31-21/h1-4,8,13,16,18-21,25-28H,5-7,9-10H2/t16-,18-,19+,20-,21+/s2
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n/an/a 0.366n/an/an/an/an/an/a



GREEN CROSS CORPORATION

US Patent


Assay Description
For sodium-dependent glucose transport assay, cells expressing hSGLT2 were seeded into a 96-well culture plate at a density of 5x104 cells/well in RP...


US Patent US9034921 (2015)

More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM159528
PNG
(US9034921, E171)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1cc(Cc2ccc(C=C)cc2)c(Cl)c2OCCc12
Show InChI InChI=1/C23H25ClO6/c1-2-12-3-5-13(6-4-12)9-14-10-16(15-7-8-29-22(15)18(14)24)23-21(28)20(27)19(26)17(11-25)30-23/h2-6,10,17,19-21,23,25-28H,1,7-9,11H2/t17-,19-,20+,21-,23+/s2
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n/an/a 0.366n/an/an/an/an/an/a



GREEN CROSS CORPORATION

US Patent


Assay Description
For sodium-dependent glucose transport assay, cells expressing hSGLT2 were seeded into a 96-well culture plate at a density of 5x104 cells/well in RP...


US Patent US9034921 (2015)

More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM159520
PNG
(US9034921, E162)
Show SMILES CCc1ccc(Cc2cc([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)c3OCOc3c2Cl)cc1
Show InChI InChI=1/C22H25ClO7/c1-2-11-3-5-12(6-4-11)7-13-8-14(21-22(16(13)23)29-10-28-21)20-19(27)18(26)17(25)15(9-24)30-20/h3-6,8,15,17-20,24-27H,2,7,9-10H2,1H3/t15-,17-,18+,19-,20+/s2
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n/an/a 0.404n/an/an/an/an/an/a



GREEN CROSS CORPORATION

US Patent


Assay Description
For sodium-dependent glucose transport assay, cells expressing hSGLT2 were seeded into a 96-well culture plate at a density of 5x104 cells/well in RP...


US Patent US9034921 (2015)

More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM159458
PNG
(US9034921, E098)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1cc(Cc2ccc3OCCOc3c2)c(Cl)cc1O
Show InChI InChI=1/C21H23ClO7S/c1-30-21-19(26)17(24)18(25)20(29-21)12-8-11(13(22)9-14(12)23)6-10-2-3-15-16(7-10)28-5-4-27-15/h2-3,7-9,17-21,23-26H,4-6H2,1H3/t17-,18-,19+,20+,21-/s2
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n/an/a 0.454n/an/an/an/an/an/a



GREEN CROSS CORPORATION

US Patent


Assay Description
For sodium-dependent glucose transport assay, cells expressing hSGLT2 were seeded into a 96-well culture plate at a density of 5x104 cells/well in RP...


US Patent US9034921 (2015)

More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM159529
PNG
(US9034921, E172)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1cc(Cc2ccc(cc2)C2CC2)c(Cl)c2OCCc12
Show InChI InChI=1/C24H27ClO6/c25-19-15(9-12-1-3-13(4-2-12)14-5-6-14)10-17(16-7-8-30-23(16)19)24-22(29)21(28)20(27)18(11-26)31-24/h1-4,10,14,18,20-22,24,26-29H,5-9,11H2/t18-,20-,21+,22-,24+/s2
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n/an/a 0.463n/an/an/an/an/an/a



GREEN CROSS CORPORATION

US Patent


Assay Description
For sodium-dependent glucose transport assay, cells expressing hSGLT2 were seeded into a 96-well culture plate at a density of 5x104 cells/well in RP...


US Patent US9034921 (2015)

More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM159474
PNG
(US9034921, E116)
Show SMILES CN(C)c1ccc(Cc2cc([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)c3CCCc3c2Cl)cc1
Show InChI InChI=1/C24H30ClNO5/c1-26(2)15-8-6-13(7-9-15)10-14-11-18(16-4-3-5-17(16)20(14)25)24-23(30)22(29)21(28)19(12-27)31-24/h6-9,11,19,21-24,27-30H,3-5,10,12H2,1-2H3/t19-,21-,22+,23-,24+/s2
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US Patent
n/an/a 0.475n/an/an/an/an/an/a



GREEN CROSS CORPORATION

US Patent


Assay Description
For sodium-dependent glucose transport assay, cells expressing hSGLT2 were seeded into a 96-well culture plate at a density of 5x104 cells/well in RP...


US Patent US9034921 (2015)

More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM20880
PNG
((2S,3R,4R,5S,6R)-2-{4-chloro-3-[(4-ethoxyphenyl)me...)
Show SMILES CCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C21H25ClO6/c1-2-27-15-6-3-12(4-7-15)9-14-10-13(5-8-16(14)22)21-20(26)19(25)18(24)17(11-23)28-21/h3-8,10,17-21,23-26H,2,9,11H2,1H3/t17-,18-,19+,20-,21+/m1/s1
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n/an/a 0.490n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM20880
PNG
((2S,3R,4R,5S,6R)-2-{4-chloro-3-[(4-ethoxyphenyl)me...)
Show SMILES CCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C21H25ClO6/c1-2-27-15-6-3-12(4-7-15)9-14-10-13(5-8-16(14)22)21-20(26)19(25)18(24)17(11-23)28-21/h3-8,10,17-21,23-26H,2,9,11H2,1H3/t17-,18-,19+,20-,21+/m1/s1
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n/an/a 0.490n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SGLT2 expressed in CHO cells by liquid scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM20880
PNG
((2S,3R,4R,5S,6R)-2-{4-chloro-3-[(4-ethoxyphenyl)me...)
Show SMILES CCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C21H25ClO6/c1-2-27-15-6-3-12(4-7-15)9-14-10-13(5-8-16(14)22)21-20(26)19(25)18(24)17(11-23)28-21/h3-8,10,17-21,23-26H,2,9,11H2,1H3/t17-,18-,19+,20-,21+/m1/s1
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n/an/a 0.490n/an/an/an/an/an/a



Green Cross Corporation Research Center

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation counter


Citation and Details
More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM20880
PNG
((2S,3R,4R,5S,6R)-2-{4-chloro-3-[(4-ethoxyphenyl)me...)
Show SMILES CCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C21H25ClO6/c1-2-27-15-6-3-12(4-7-15)9-14-10-13(5-8-16(14)22)21-20(26)19(25)18(24)17(11-23)28-21/h3-8,10,17-21,23-26H,2,9,11H2,1H3/t17-,18-,19+,20-,21+/m1/s1
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n/an/a 0.490n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM20880
PNG
((2S,3R,4R,5S,6R)-2-{4-chloro-3-[(4-ethoxyphenyl)me...)
Show SMILES CCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C21H25ClO6/c1-2-27-15-6-3-12(4-7-15)9-14-10-13(5-8-16(14)22)21-20(26)19(25)18(24)17(11-23)28-21/h3-8,10,17-21,23-26H,2,9,11H2,1H3/t17-,18-,19+,20-,21+/m1/s1
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n/an/a 0.490n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintilla...


Citation and Details
More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM20880
PNG
((2S,3R,4R,5S,6R)-2-{4-chloro-3-[(4-ethoxyphenyl)me...)
Show SMILES CCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C21H25ClO6/c1-2-27-15-6-3-12(4-7-15)9-14-10-13(5-8-16(14)22)21-20(26)19(25)18(24)17(11-23)28-21/h3-8,10,17-21,23-26H,2,9,11H2,1H3/t17-,18-,19+,20-,21+/m1/s1
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n/an/a 0.490n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 assessed as inhibition of methyl-alpha-D-glucopyranoside uptake by cell based assay


Citation and Details
More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM20880
PNG
((2S,3R,4R,5S,6R)-2-{4-chloro-3-[(4-ethoxyphenyl)me...)
Show SMILES CCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C21H25ClO6/c1-2-27-15-6-3-12(4-7-15)9-14-10-13(5-8-16(14)22)21-20(26)19(25)18(24)17(11-23)28-21/h3-8,10,17-21,23-26H,2,9,11H2,1H3/t17-,18-,19+,20-,21+/m1/s1
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n/an/a 0.490n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM20880
PNG
((2S,3R,4R,5S,6R)-2-{4-chloro-3-[(4-ethoxyphenyl)me...)
Show SMILES CCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C21H25ClO6/c1-2-27-15-6-3-12(4-7-15)9-14-10-13(5-8-16(14)22)21-20(26)19(25)18(24)17(11-23)28-21/h3-8,10,17-21,23-26H,2,9,11H2,1H3/t17-,18-,19+,20-,21+/m1/s1
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n/an/a 0.490n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2


Citation and Details
More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM159468
PNG
(US9034921, E110)
Show SMILES COc1ccc(Cc2cc([C@@H]3O[C@H](SC)[C@@H](O)[C@H](O)[C@H]3O)c(OCC=C)cc2Cl)cc1
Show InChI InChI=1/C23H27ClO6S/c1-4-9-29-18-12-17(24)14(10-13-5-7-15(28-2)8-6-13)11-16(18)22-20(26)19(25)21(27)23(30-22)31-3/h4-8,11-12,19-23,25-27H,1,9-10H2,2-3H3/t19-,20-,21+,22+,23-/s2
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US Patent
n/an/a 0.504n/an/an/an/an/an/a



GREEN CROSS CORPORATION

US Patent


Assay Description
For sodium-dependent glucose transport assay, cells expressing hSGLT2 were seeded into a 96-well culture plate at a density of 5x104 cells/well in RP...


US Patent US9034921 (2015)

More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM159394
PNG
(US9034921, E008)
Show SMILES CCOc1ccc(Cc2cc([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)c3CCCc3c2Cl)cc1
Show InChI InChI=1/C24H29ClO6/c1-2-30-15-8-6-13(7-9-15)10-14-11-18(16-4-3-5-17(16)20(14)25)24-23(29)22(28)21(27)19(12-26)31-24/h6-9,11,19,21-24,26-29H,2-5,10,12H2,1H3/t19-,21-,22+,23-,24+/s2
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US Patent
n/an/a 0.551n/an/an/an/an/an/a



GREEN CROSS CORPORATION

US Patent


Assay Description
For sodium-dependent glucose transport assay, cells expressing hSGLT2 were seeded into a 96-well culture plate at a density of 5x104 cells/well in RP...


US Patent US9034921 (2015)

More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM159471
PNG
(US9034921, E113)
Show SMILES COc1cc(cc(Cc2ccc3OCCOc3c2)c1Cl)[C@@H]1O[C@H](SC)[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1/C22H25ClO7S/c1-27-16-10-13(21-19(25)18(24)20(26)22(30-21)31-2)9-12(17(16)23)7-11-3-4-14-15(8-11)29-6-5-28-14/h3-4,8-10,18-22,24-26H,5-7H2,1-2H3/t18-,19-,20+,21+,22-/s2
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US Patent
n/an/a 0.551n/an/an/an/an/an/a



GREEN CROSS CORPORATION

US Patent


Assay Description
For sodium-dependent glucose transport assay, cells expressing hSGLT2 were seeded into a 96-well culture plate at a density of 5x104 cells/well in RP...


US Patent US9034921 (2015)

More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM159599
PNG
(US9034921, E242)
Show SMILES COc1ccc(Cc2cc([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)c3CCCSc3c2Cl)cc1
Show InChI InChI=1/C23H27ClO6S/c1-29-14-6-4-12(5-7-14)9-13-10-16(15-3-2-8-31-23(15)18(13)24)22-21(28)20(27)19(26)17(11-25)30-22/h4-7,10,17,19-22,25-28H,2-3,8-9,11H2,1H3/t17-,19-,20+,21-,22+/s2
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n/an/a 0.552n/an/an/an/an/an/a



GREEN CROSS CORPORATION

US Patent


Assay Description
For sodium-dependent glucose transport assay, cells expressing hSGLT2 were seeded into a 96-well culture plate at a density of 5x104 cells/well in RP...


US Patent US9034921 (2015)

More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM159537
PNG
(US9034921, E180)
Show SMILES CC(=C)c1ccc(Cc2cc([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)c3CCOc3c2Cl)cc1
Show InChI InChI=1/C24H27ClO6/c1-12(2)14-5-3-13(4-6-14)9-15-10-17(16-7-8-30-23(16)19(15)25)24-22(29)21(28)20(27)18(11-26)31-24/h3-6,10,18,20-22,24,26-29H,1,7-9,11H2,2H3/t18-,20-,21+,22-,24+/s2
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n/an/a 0.574n/an/an/an/an/an/a



GREEN CROSS CORPORATION

US Patent


Assay Description
For sodium-dependent glucose transport assay, cells expressing hSGLT2 were seeded into a 96-well culture plate at a density of 5x104 cells/well in RP...


US Patent US9034921 (2015)

More data for this
Ligand-Target Pair
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