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Found 2569 hits Enz. Inhib. hit(s) with Target = 'streptokinase A precursor' AND taxid = 301447   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
streptokinase A precursor


(Streptococcus pyogenes M1 GAS)
BDBM57507
PNG
(MLS000585514 | N'-[(1E)-(2-hydroxy-3-methoxy-5...)
Show SMILES COc1cc(c[c-](\C=[NH+]\NC(=O)C(C)Nc2cccc(C)c2)c1=O)[N+]([O-])=O
Show InChI InChI=1S/C18H19N4O5/c1-11-5-4-6-14(7-11)20-12(2)18(24)21-19-10-13-8-15(22(25)26)9-16(27-3)17(13)23/h4-10,12,20H,1-3H3,(H,21,24)/q-1/p+1/b19-10+
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n/an/an/an/a 1.50E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Group A streptococcus, GAS, streptokinase, expression, virulence, inhibition, dose response, EC50 Assay Overview: The goal of this assa...


PubChem Bioassay (2009)

More data for this
Ligand-Target Pair
streptokinase A precursor


(Streptococcus pyogenes M1 GAS)
BDBM57508
PNG
(2-Hydroxy-benzoic acid [1-(8-hydroxy-2,3,6,7-tetra...)
Show SMILES Oc1ccccc1C(=O)NN\C=C1/C=C2CCCN3CCCC(C1=O)=C23
Show InChI InChI=1S/C20H21N3O3/c24-17-8-2-1-6-15(17)20(26)22-21-12-14-11-13-5-3-9-23-10-4-7-16(18(13)23)19(14)25/h1-2,6,8,11-12,21,24H,3-5,7,9-10H2,(H,22,26)/b14-12+
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n/an/an/an/a 1.50E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Group A streptococcus, GAS, streptokinase, expression, virulence, inhibition, dose response, EC50 Assay Overview: The goal of this assa...


PubChem Bioassay (2009)

More data for this
Ligand-Target Pair
streptokinase A precursor


(Streptococcus pyogenes M1 GAS)
BDBM57509
PNG
(4-Chloro-N-(5,6,7,8-tetrahydro-naphthalen-1-yl)-be...)
Show SMILES Clc1ccc(cc1)S(=O)(=O)Nc1cccc2CCCCc12
Show InChI InChI=1S/C16H16ClNO2S/c17-13-8-10-14(11-9-13)21(19,20)18-16-7-3-5-12-4-1-2-6-15(12)16/h3,5,7-11,18H,1-2,4,6H2
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n/an/an/an/a 9.78E+4n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Group A streptococcus, GAS, streptokinase, expression, virulence, inhibition, dose response, EC50 Assay Overview: The goal of this assa...


PubChem Bioassay (2009)

More data for this
Ligand-Target Pair
streptokinase A precursor


(Streptococcus pyogenes M1 GAS)
BDBM57510
PNG
(1H-benzimidazol-2-yl-[(3,5-dimethyl-1-phenyl-pyraz...)
Show SMILES Cc1nn(c(C)c1CN=Nc1nc2ccccc2[nH]1)-c1ccccc1
Show InChI InChI=1S/C19H18N6/c1-13-16(14(2)25(24-13)15-8-4-3-5-9-15)12-20-23-19-21-17-10-6-7-11-18(17)22-19/h3-11H,12H2,1-2H3,(H,21,22)
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n/an/an/an/a 1.50E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Group A streptococcus, GAS, streptokinase, expression, virulence, inhibition, dose response, EC50 Assay Overview: The goal of this assa...


PubChem Bioassay (2009)

More data for this
Ligand-Target Pair
streptokinase A precursor


(Streptococcus pyogenes M1 GAS)
BDBM57511
PNG
((3-Methoxy-phenyl)-(2-methyl-3-phenyl-6,7-dihydro-...)
Show SMILES COc1cccc(Nc2c3CCCc3nc3c(c(C)nn23)-c2ccccc2)c1
Show InChI InChI=1S/C23H22N4O/c1-15-21(16-8-4-3-5-9-16)23-25-20-13-7-12-19(20)22(27(23)26-15)24-17-10-6-11-18(14-17)28-2/h3-6,8-11,14,24H,7,12-13H2,1-2H3
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n/an/an/an/a 8.91E+3n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Group A streptococcus, GAS, streptokinase, expression, virulence, inhibition, dose response, EC50 Assay Overview: The goal of this assa...


PubChem Bioassay (2009)

More data for this
Ligand-Target Pair
streptokinase A precursor


(Streptococcus pyogenes M1 GAS)
BDBM57512
PNG
(4-Fluoro-N-[4-(6-methyl-benzothiazol-2-yl)-phenyl]...)
Show SMILES Cc1ccc2nc(sc2c1)-c1ccc(NS(=O)(=O)c2ccc(F)cc2)cc1
Show InChI InChI=1S/C20H15FN2O2S2/c1-13-2-11-18-19(12-13)26-20(22-18)14-3-7-16(8-4-14)23-27(24,25)17-9-5-15(21)6-10-17/h2-12,23H,1H3
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n/an/an/an/a 1.50E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Group A streptococcus, GAS, streptokinase, expression, virulence, inhibition, dose response, EC50 Assay Overview: The goal of this assa...


PubChem Bioassay (2009)

More data for this
Ligand-Target Pair
streptokinase A precursor


(Streptococcus pyogenes M1 GAS)
BDBM57513
PNG
((3Z)-2-keto-N'-[(E)-(6-ketocyclohexa-2,4-dien-1-yl...)
Show SMILES Oc1ccccc1C=NNC(=O)C(=O)CC1=NC2(CCCC2)Cc2ccccc12
Show InChI InChI=1S/C23H23N3O3/c27-20-10-4-2-8-17(20)15-24-26-22(29)21(28)13-19-18-9-3-1-7-16(18)14-23(25-19)11-5-6-12-23/h1-4,7-10,15,27H,5-6,11-14H2,(H,26,29)
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n/an/an/an/a 1.50E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Group A streptococcus, GAS, streptokinase, expression, virulence, inhibition, dose response, EC50 Assay Overview: The goal of this assa...


PubChem Bioassay (2009)

More data for this
Ligand-Target Pair
streptokinase A precursor


(Streptococcus pyogenes M1 GAS)
BDBM57514
PNG
((6E)-5-azanylidene-6-[[1-(3,5-dimethylphenyl)-2,5-...)
Show SMILES CC(C)CC1=NN2C(S1)=NC(=O)\C(=C\c1cc(C)n(c1C)-c1cc(C)cc(C)c1)C2=N
Show InChI InChI=1S/C24H27N5OS/c1-13(2)7-21-27-29-22(25)20(23(30)26-24(29)31-21)12-18-11-16(5)28(17(18)6)19-9-14(3)8-15(4)10-19/h8-13,25H,7H2,1-6H3/b20-12+,25-22?
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n/an/an/an/a 5.00E+4n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Group A streptococcus, GAS, streptokinase, expression, virulence, inhibition, dose response, EC50 Assay Overview: The goal of this assa...


PubChem Bioassay (2009)

More data for this
Ligand-Target Pair
streptokinase A precursor


(Streptococcus pyogenes M1 GAS)
BDBM57515
PNG
((5E)-1-butan-2-yl-5-[(2-phenylhydrazinyl)methylide...)
Show SMILES CCC(C)N1C(=S)NC(=O)C(=CNNc2ccccc2)C1=O
Show InChI InChI=1S/C15H18N4O2S/c1-3-10(2)19-14(21)12(13(20)17-15(19)22)9-16-18-11-7-5-4-6-8-11/h4-10,16,18H,3H2,1-2H3,(H,17,20,22)
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n/an/an/an/a 1.50E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Group A streptococcus, GAS, streptokinase, expression, virulence, inhibition, dose response, EC50 Assay Overview: The goal of this assa...


PubChem Bioassay (2009)

More data for this
Ligand-Target Pair
streptokinase A precursor


(Streptococcus pyogenes M1 GAS)
BDBM57516
PNG
(4-[2-[[4-(2-chlorobenzoyl)oxyphenyl]methylidene]hy...)
Show SMILES OC(=O)c1ccc(cc1)N=NCc1ccc(OC(=O)c2ccccc2Cl)cc1
Show InChI InChI=1S/C21H15ClN2O4/c22-19-4-2-1-3-18(19)21(27)28-17-11-5-14(6-12-17)13-23-24-16-9-7-15(8-10-16)20(25)26/h1-12H,13H2,(H,25,26)
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n/an/an/an/a 1.50E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Group A streptococcus, GAS, streptokinase, expression, virulence, inhibition, dose response, EC50 Assay Overview: The goal of this assa...


PubChem Bioassay (2009)

More data for this
Ligand-Target Pair
streptokinase A precursor


(Streptococcus pyogenes M1 GAS)
BDBM57517
PNG
(2-(4-bromophenyl)-N-(4-{[(4-methyl-2-pyrimidinyl)a...)
Show SMILES Cc1ccnc(NS(=O)(=O)c2ccc(NC(=O)c3cc(nc4ccccc34)-c3ccc(Br)cc3)cc2)n1
Show InChI InChI=1S/C27H20BrN5O3S/c1-17-14-15-29-27(30-17)33-37(35,36)21-12-10-20(11-13-21)31-26(34)23-16-25(18-6-8-19(28)9-7-18)32-24-5-3-2-4-22(23)24/h2-16H,1H3,(H,31,34)(H,29,30,33)
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n/an/an/an/a 5.84E+3n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Group A streptococcus, GAS, streptokinase, expression, virulence, inhibition, dose response, EC50 Assay Overview: The goal of this assa...


PubChem Bioassay (2009)

More data for this
Ligand-Target Pair
streptokinase A precursor


(Streptococcus pyogenes M1 GAS)
BDBM57518
PNG
(MLS000589712 | N-[N'-(2,4-Dichloro-benzoyl)-hy...)
Show SMILES Clc1ccc(C(=O)NNC(=S)NC(=O)c2cccnc2)c(Cl)c1
Show InChI InChI=1S/C14H10Cl2N4O2S/c15-9-3-4-10(11(16)6-9)13(22)19-20-14(23)18-12(21)8-2-1-5-17-7-8/h1-7H,(H,19,22)(H2,18,20,21,23)
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n/an/an/an/a 1.50E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Group A streptococcus, GAS, streptokinase, expression, virulence, inhibition, dose response, EC50 Assay Overview: The goal of this assa...


PubChem Bioassay (2009)

More data for this
Ligand-Target Pair
streptokinase A precursor


(Streptococcus pyogenes M1 GAS)
BDBM57519
PNG
(7-(2,3-Dimethoxy-phenyl)-9-[1-(3-hydroxy-phenyl)-m...)
Show SMILES COc1cccc(C2C3=C(N=c4sc(=Cc5cccc(O)c5)c(=O)n24)c2ccccc2CC3)c1OC
Show InChI InChI=1S/C29H24N2O4S/c1-34-23-12-6-11-22(27(23)35-2)26-21-14-13-18-8-3-4-10-20(18)25(21)30-29-31(26)28(33)24(36-29)16-17-7-5-9-19(32)15-17/h3-12,15-16,26,32H,13-14H2,1-2H3
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n/an/an/an/a 6.31E+3n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Group A streptococcus, GAS, streptokinase, expression, virulence, inhibition, dose response, EC50 Assay Overview: The goal of this assa...


PubChem Bioassay (2009)

More data for this
Ligand-Target Pair
streptokinase A precursor


(Streptococcus pyogenes M1 GAS)
BDBM47583
PNG
(1-Ethyl-6-fluoro-7-[N'-(2-nitro-benzylidene)-h...)
Show SMILES CCn1cc(C(O)=O)c(=O)c2cc(F)c(cc12)N=NCc1ccccc1[N+]([O-])=O
Show InChI InChI=1S/C19H15FN4O5/c1-2-23-10-13(19(26)27)18(25)12-7-14(20)15(8-17(12)23)22-21-9-11-5-3-4-6-16(11)24(28)29/h3-8,10H,2,9H2,1H3,(H,26,27)
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n/an/an/an/a 1.50E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Group A streptococcus, GAS, streptokinase, expression, virulence, inhibition, dose response, EC50 Assay Overview: The goal of this assa...


PubChem Bioassay (2009)

More data for this
Ligand-Target Pair
streptokinase A precursor


(Streptococcus pyogenes M1 GAS)
BDBM54885
PNG
(BRD-K67237401-001-04-0 | N,N-diethylcarbamodithioi...)
Show SMILES CCN(CC)C(=S)SCC(=O)Nc1nc(c(o1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C22H23N3O2S2/c1-3-25(4-2)22(28)29-15-18(26)23-21-24-19(16-11-7-5-8-12-16)20(27-21)17-13-9-6-10-14-17/h5-14H,3-4,15H2,1-2H3,(H,23,24,26)
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n/an/an/an/a 8.54E+3n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Group A streptococcus, GAS, streptokinase, expression, virulence, inhibition, dose response, EC50 Assay Overview: The goal of this assa...


PubChem Bioassay (2009)

More data for this
Ligand-Target Pair
streptokinase A precursor


(Streptococcus pyogenes M1 GAS)
BDBM57520
PNG
(MLS000583235 | N-({[3-chloro-2-(1-piperidinyl)phen...)
Show SMILES Clc1cccc(NC(=S)NC(=O)c2ccc3OCCOc3c2)c1N1CCCCC1
Show InChI InChI=1S/C21H22ClN3O3S/c22-15-5-4-6-16(19(15)25-9-2-1-3-10-25)23-21(29)24-20(26)14-7-8-17-18(13-14)28-12-11-27-17/h4-8,13H,1-3,9-12H2,(H2,23,24,26,29)
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n/an/an/an/a 4.80E+4n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Group A streptococcus, GAS, streptokinase, expression, virulence, inhibition, dose response, EC50 Assay Overview: The goal of this assa...


PubChem Bioassay (2009)

More data for this
Ligand-Target Pair
streptokinase A precursor


(Streptococcus pyogenes M1 GAS)
BDBM33739
PNG
(2-(3-morpholinopropanoylamino)-4-(p-tolyl)thiophen...)
Show SMILES CCOC(=O)c1c(NC(=O)CCN2CCOCC2)scc1-c1ccc(C)cc1
Show InChI InChI=1S/C21H26N2O4S/c1-3-27-21(25)19-17(16-6-4-15(2)5-7-16)14-28-20(19)22-18(24)8-9-23-10-12-26-13-11-23/h4-7,14H,3,8-13H2,1-2H3,(H,22,24)
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n/an/an/an/a 6.54E+4n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Group A streptococcus, GAS, streptokinase, expression, virulence, inhibition, dose response, EC50 Assay Overview: The goal of this assa...


PubChem Bioassay (2009)

More data for this
Ligand-Target Pair
streptokinase A precursor


(Streptococcus pyogenes M1 GAS)
BDBM57521
PNG
(MLS000582986 | N-({2-[4-(isobutyrylamino)benzoyl]h...)
Show SMILES CC(C)C(=O)Nc1ccc(cc1)C(=O)NNC(=S)NC(=O)c1cccs1
Show InChI InChI=1S/C17H18N4O3S2/c1-10(2)14(22)18-12-7-5-11(6-8-12)15(23)20-21-17(25)19-16(24)13-4-3-9-26-13/h3-10H,1-2H3,(H,18,22)(H,20,23)(H2,19,21,24,25)
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n/an/an/an/a 1.50E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Group A streptococcus, GAS, streptokinase, expression, virulence, inhibition, dose response, EC50 Assay Overview: The goal of this assa...


PubChem Bioassay (2009)

More data for this
Ligand-Target Pair
streptokinase A precursor


(Streptococcus pyogenes M1 GAS)
BDBM57522
PNG
(2-(phenoxymethyl)-5H-spiro[benzo[h][1,2,4]triazolo...)
Show SMILES C(Oc1ccccc1)c1nc2c3c(ncn2n1)-c1ccccc1CC31CCCC1
Show InChI InChI=1S/C24H22N4O/c1-2-9-18(10-3-1)29-15-20-26-23-21-22(25-16-28(23)27-20)19-11-5-4-8-17(19)14-24(21)12-6-7-13-24/h1-5,8-11,16H,6-7,12-15H2
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n/an/an/an/a 2.20E+4n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Group A streptococcus, GAS, streptokinase, expression, virulence, inhibition, dose response, EC50 Assay Overview: The goal of this assa...


PubChem Bioassay (2009)

More data for this
Ligand-Target Pair
streptokinase A precursor


(Streptococcus pyogenes M1 GAS)
BDBM57523
PNG
(3-methyl-4-[[4-(2,4,6-trimethylbenzyl)oxybenzylide...)
Show SMILES Cc1n[nH]c(=S)n1N=Cc1ccc(OCc2c(C)cc(C)cc2C)cc1
Show InChI InChI=1S/C20H22N4OS/c1-13-9-14(2)19(15(3)10-13)12-25-18-7-5-17(6-8-18)11-21-24-16(4)22-23-20(24)26/h5-11H,12H2,1-4H3,(H,23,26)
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n/an/an/an/a 1.20E+4n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Group A streptococcus, GAS, streptokinase, expression, virulence, inhibition, dose response, EC50 Assay Overview: The goal of this assa...


PubChem Bioassay (2009)

More data for this
Ligand-Target Pair
streptokinase A precursor


(Streptococcus pyogenes M1 GAS)
BDBM57524
PNG
(MLS000568816 | N-[(2-thiophen-2-ylethanoylamino)ca...)
Show SMILES O=C(Cc1cccs1)NNC(=S)NC(=O)c1ccccc1
Show InChI InChI=1S/C14H13N3O2S2/c18-12(9-11-7-4-8-21-11)16-17-14(20)15-13(19)10-5-2-1-3-6-10/h1-8H,9H2,(H,16,18)(H2,15,17,19,20)
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n/an/an/an/a 1.50E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Group A streptococcus, GAS, streptokinase, expression, virulence, inhibition, dose response, EC50 Assay Overview: The goal of this assa...


PubChem Bioassay (2009)

More data for this
Ligand-Target Pair
streptokinase A precursor


(Streptococcus pyogenes M1 GAS)
BDBM57525
PNG
(3-[2-(4-Hydroxy-phenylamino)-thiazol-4-yl]-6-metho...)
Show SMILES COc1ccc2oc(=O)c(cc2c1)-c1csc(Nc2ccc(O)cc2)n1
Show InChI InChI=1S/C19H14N2O4S/c1-24-14-6-7-17-11(8-14)9-15(18(23)25-17)16-10-26-19(21-16)20-12-2-4-13(22)5-3-12/h2-10,22H,1H3,(H,20,21)
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n/an/an/an/a 1.50E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Group A streptococcus, GAS, streptokinase, expression, virulence, inhibition, dose response, EC50 Assay Overview: The goal of this assa...


PubChem Bioassay (2009)

More data for this
Ligand-Target Pair
streptokinase A precursor


(Streptococcus pyogenes M1 GAS)
BDBM57526
PNG
(11-(4-Chloro-phenyl)-11,11a-dihydro-10-thia-5-aza-...)
Show SMILES Clc1ccc(cc1)C1Sc2ccccc2N=C2C1C(=O)c1ccccc21
Show InChI InChI=1S/C22H14ClNOS/c23-14-11-9-13(10-12-14)22-19-20(15-5-1-2-6-16(15)21(19)25)24-17-7-3-4-8-18(17)26-22/h1-12,19,22H
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n/an/an/an/a 1.50E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Group A streptococcus, GAS, streptokinase, expression, virulence, inhibition, dose response, EC50 Assay Overview: The goal of this assa...


PubChem Bioassay (2009)

More data for this
Ligand-Target Pair
streptokinase A precursor


(Streptococcus pyogenes M1 GAS)
BDBM57527
PNG
((pyridin-4-ylmethylideneamino) N-(3,4-dichlorophen...)
Show SMILES Clc1ccc(NC(=O)ON=Cc2ccncc2)cc1Cl
Show InChI InChI=1S/C13H9Cl2N3O2/c14-11-2-1-10(7-12(11)15)18-13(19)20-17-8-9-3-5-16-6-4-9/h1-8H,(H,18,19)
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n/an/an/an/a 1.50E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Group A streptococcus, GAS, streptokinase, expression, virulence, inhibition, dose response, EC50 Assay Overview: The goal of this assa...


PubChem Bioassay (2009)

More data for this
Ligand-Target Pair
streptokinase A precursor


(Streptococcus pyogenes M1 GAS)
BDBM57566
PNG
(1-benzyl-3-[(4-ketospiro[1,6-dihydrobenzo[h]quinaz...)
Show SMILES O=c1[nH]c(NNC(=S)NCc2ccccc2)nc2-c3ccccc3CC3(CCCCC3)c12
Show InChI InChI=1S/C25H27N5OS/c31-22-20-21(19-12-6-5-11-18(19)15-25(20)13-7-2-8-14-25)27-23(28-22)29-30-24(32)26-16-17-9-3-1-4-10-17/h1,3-6,9-12H,2,7-8,13-16H2,(H2,26,30,32)(H2,27,28,29,31)
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n/an/an/an/a 4.58E+3n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Group A streptococcus, GAS, streptokinase, expression, virulence, inhibition, dose response, EC50 Assay Overview: The goal of this assa...


PubChem Bioassay (2009)

More data for this
Ligand-Target Pair
streptokinase A precursor


(Streptococcus pyogenes M1 GAS)
BDBM54843
PNG
(5-(2,3-dihydro-1,4-benzodioxin-3-ylmethylsulfamoyl...)
Show SMILES CC(C)c1ccc(NC(=O)c2cc(ccc2F)S(=O)(=O)NCC2COc3ccccc3O2)cc1
Show InChI InChI=1S/C25H25FN2O5S/c1-16(2)17-7-9-18(10-8-17)28-25(29)21-13-20(11-12-22(21)26)34(30,31)27-14-19-15-32-23-5-3-4-6-24(23)33-19/h3-13,16,19,27H,14-15H2,1-2H3,(H,28,29)
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n/an/an/an/a 3.53E+3n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Group A streptococcus, GAS, streptokinase, expression, virulence, inhibition, dose response, EC50 Assay Overview: The goal of this assa...


PubChem Bioassay (2009)

More data for this
Ligand-Target Pair
streptokinase A precursor


(Streptococcus pyogenes M1 GAS)
BDBM57567
PNG
(MLS000589396 | N-[(2,4-dimethoxyphenyl)methylidene...)
Show SMILES COc1ccc(CN=Nc2cc(C)nc(n2)-n2nc(C)cc2C)c(OC)c1
Show InChI InChI=1S/C19H22N6O2/c1-12-9-18(22-19(21-12)25-14(3)8-13(2)24-25)23-20-11-15-6-7-16(26-4)10-17(15)27-5/h6-10H,11H2,1-5H3
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n/an/an/an/a 1.50E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Group A streptococcus, GAS, streptokinase, expression, virulence, inhibition, dose response, EC50 Assay Overview: The goal of this assa...


PubChem Bioassay (2009)

More data for this
Ligand-Target Pair
streptokinase A precursor


(Streptococcus pyogenes M1 GAS)
BDBM45136
PNG
(3,6-Diamino-2-benzoyl-4-(4-methoxy-phenyl)-thieno[...)
Show SMILES COc1ccc(cc1)-c1c(C#N)c(N)nc2sc(C(=O)c3ccccc3)c(N)c12
Show InChI InChI=1S/C22H16N4O2S/c1-28-14-9-7-12(8-10-14)16-15(11-23)21(25)26-22-17(16)18(24)20(29-22)19(27)13-5-3-2-4-6-13/h2-10H,24H2,1H3,(H2,25,26)
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n/an/an/an/a 1.50E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Group A streptococcus, GAS, streptokinase, expression, virulence, inhibition, dose response, EC50 Assay Overview: The goal of this assa...


PubChem Bioassay (2009)

More data for this
Ligand-Target Pair
streptokinase A precursor


(Streptococcus pyogenes M1 GAS)
BDBM57568
PNG
(5-(Naphthalen-1-ylazo)-4-phenyl-thiazol-2-ylamine ...)
Show SMILES Nc1nc(c(N=Nc2cccc3ccccc23)s1)-c1ccccc1
Show InChI InChI=1S/C19H14N4S/c20-19-21-17(14-8-2-1-3-9-14)18(24-19)23-22-16-12-6-10-13-7-4-5-11-15(13)16/h1-12H,(H2,20,21)
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n/an/an/an/a 1.50E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Group A streptococcus, GAS, streptokinase, expression, virulence, inhibition, dose response, EC50 Assay Overview: The goal of this assa...


PubChem Bioassay (2009)

More data for this
Ligand-Target Pair
streptokinase A precursor


(Streptococcus pyogenes M1 GAS)
BDBM33748
PNG
(1-(2,4-dichlorophenyl)-2-[4-[2-(4-nitrophenyl)-2-o...)
Show SMILES [O-][N+](=O)c1ccc(cc1)C(=O)C[n+]1cnn(CC(=O)c2ccc(Cl)cc2Cl)c1
Show InChI InChI=1S/C18H13Cl2N4O4/c19-13-3-6-15(16(20)7-13)18(26)9-23-11-22(10-21-23)8-17(25)12-1-4-14(5-2-12)24(27)28/h1-7,10-11H,8-9H2/q+1
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n/an/an/an/a 2.14E+4n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Group A streptococcus, GAS, streptokinase, expression, virulence, inhibition, dose response, EC50 Assay Overview: The goal of this assa...


PubChem Bioassay (2009)

More data for this
Ligand-Target Pair
streptokinase A precursor


(Streptococcus pyogenes M1 GAS)
BDBM57569
PNG
((5E)-5-(3-bromobenzylidene)-2-[N'-(1,7,7-trimethyl...)
Show SMILES CC1(C)C2CCC1(C)C(C2)=NNC1=NC(=O)C(S1)=Cc1cccc(Br)c1
Show InChI InChI=1S/C20H22BrN3OS/c1-19(2)13-7-8-20(19,3)16(11-13)23-24-18-22-17(25)15(26-18)10-12-5-4-6-14(21)9-12/h4-6,9-10,13H,7-8,11H2,1-3H3,(H,22,24,25)
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n/an/an/an/a 1.50E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Group A streptococcus, GAS, streptokinase, expression, virulence, inhibition, dose response, EC50 Assay Overview: The goal of this assa...


PubChem Bioassay (2009)

More data for this
Ligand-Target Pair
streptokinase A precursor


(Streptococcus pyogenes M1 GAS)
BDBM57570
PNG
(4-[[2-[4-(4-chlorophenyl)-6-(trifluoromethyl)pyrim...)
Show SMILES Oc1ccc(CN=Nc2nc(cc(n2)C(F)(F)F)-c2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C18H12ClF3N4O/c19-13-5-3-12(4-6-13)15-9-16(18(20,21)22)25-17(24-15)26-23-10-11-1-7-14(27)8-2-11/h1-9,27H,10H2
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n/an/an/an/a 1.63E+4n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Group A streptococcus, GAS, streptokinase, expression, virulence, inhibition, dose response, EC50 Assay Overview: The goal of this assa...


PubChem Bioassay (2009)

More data for this
Ligand-Target Pair
streptokinase A precursor


(Streptococcus pyogenes M1 GAS)
BDBM57571
PNG
(2-(3,5-dimethyl-1-pyrazolyl)-N-[(2-methoxyphenyl)m...)
Show SMILES COc1ccccc1CN=Nc1cc(C)nc(n1)-n1nc(C)cc1C
Show InChI InChI=1S/C18H20N6O/c1-12-10-17(21-18(20-12)24-14(3)9-13(2)23-24)22-19-11-15-7-5-6-8-16(15)25-4/h5-10H,11H2,1-4H3
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n/an/an/an/a 1.50E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Group A streptococcus, GAS, streptokinase, expression, virulence, inhibition, dose response, EC50 Assay Overview: The goal of this assa...


PubChem Bioassay (2009)

More data for this
Ligand-Target Pair
streptokinase A precursor


(Streptococcus pyogenes M1 GAS)
BDBM58641
PNG
(5-bromanyl-N-[2-(4-methylpiperidin-1-yl)phenyl]fur...)
Show SMILES CC1CCN(CC1)c1ccccc1NC(=O)c1ccc(Br)o1
Show InChI InChI=1S/C17H19BrN2O2/c1-12-8-10-20(11-9-12)14-5-3-2-4-13(14)19-17(21)15-6-7-16(18)22-15/h2-7,12H,8-11H2,1H3,(H,19,21)
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n/an/an/an/a 4.36E+4n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Group A streptococcus, GAS, streptokinase, expression, virulence, inhibition, dose response, EC50 Assay Overview: The goal of this assa...


PubChem Bioassay (2009)

More data for this
Ligand-Target Pair
streptokinase A precursor


(Streptococcus pyogenes M1 GAS)
BDBM58642
PNG
(MLS001060591 | N-cycloheptyl-2-ethoxy-5-methyl-ben...)
Show SMILES CCOc1ccc(C)cc1S(=O)(=O)NC1CCCCCC1
Show InChI InChI=1S/C16H25NO3S/c1-3-20-15-11-10-13(2)12-16(15)21(18,19)17-14-8-6-4-5-7-9-14/h10-12,14,17H,3-9H2,1-2H3
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n/an/an/an/a 1.50E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Group A streptococcus, GAS, streptokinase, expression, virulence, inhibition, dose response, EC50 Assay Overview: The goal of this assa...


PubChem Bioassay (2009)

More data for this
Ligand-Target Pair
streptokinase A precursor


(Streptococcus pyogenes M1 GAS)
BDBM58643
PNG
(4-[5-(1,3-benzodioxol-5-yl)-7-(trifluoromethyl)-1,...)
Show SMILES CCOC(=O)N1CCN(CC1)C(=O)c1cc2NC(CC(n2n1)C(F)(F)F)c1ccc2OCOc2c1
Show InChI InChI=1S/C22H24F3N5O5/c1-2-33-21(32)29-7-5-28(6-8-29)20(31)15-11-19-26-14(10-18(22(23,24)25)30(19)27-15)13-3-4-16-17(9-13)35-12-34-16/h3-4,9,11,14,18,26H,2,5-8,10,12H2,1H3
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n/an/an/an/a 1.50E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Group A streptococcus, GAS, streptokinase, expression, virulence, inhibition, dose response, EC50 Assay Overview: The goal of this assa...


PubChem Bioassay (2009)

More data for this
Ligand-Target Pair
streptokinase A precursor


(Streptococcus pyogenes M1 GAS)
BDBM58644
PNG
(2-[(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)sulfan...)
Show SMILES FC(F)(F)c1cccc(NC(=O)CSc2nc(nc(n2)N2CCOCC2)N2CCOCC2)c1
Show InChI InChI=1S/C20H23F3N6O3S/c21-20(22,23)14-2-1-3-15(12-14)24-16(30)13-33-19-26-17(28-4-8-31-9-5-28)25-18(27-19)29-6-10-32-11-7-29/h1-3,12H,4-11,13H2,(H,24,30)
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n/an/an/an/a 1.50E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Group A streptococcus, GAS, streptokinase, expression, virulence, inhibition, dose response, EC50 Assay Overview: The goal of this assa...


PubChem Bioassay (2009)

More data for this
Ligand-Target Pair
streptokinase A precursor


(Streptococcus pyogenes M1 GAS)
BDBM58645
PNG
(3-[5-[1-(4-chlorophenyl)cyclobutyl]-1,3,4-oxadiazo...)
Show SMILES COCC1CCN(C1)C(=O)CCc1nnc(o1)C1(CCC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H26ClN3O3/c1-27-14-15-9-12-25(13-15)19(26)8-7-18-23-24-20(28-18)21(10-2-11-21)16-3-5-17(22)6-4-16/h3-6,15H,2,7-14H2,1H3
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n/an/an/an/a 1.50E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Group A streptococcus, GAS, streptokinase, expression, virulence, inhibition, dose response, EC50 Assay Overview: The goal of this assa...


PubChem Bioassay (2009)

More data for this
Ligand-Target Pair
streptokinase A precursor


(Streptococcus pyogenes M1 GAS)
BDBM58646
PNG
(MLS001072370 | SMR000654502 | [4-(7-chloro-3,5-dim...)
Show SMILES Cc1c(oc2c(Cl)cc(C)cc12)C(=O)N1CCN(CC1)C(=O)c1ccco1
Show InChI InChI=1S/C20H19ClN2O4/c1-12-10-14-13(2)17(27-18(14)15(21)11-12)20(25)23-7-5-22(6-8-23)19(24)16-4-3-9-26-16/h3-4,9-11H,5-8H2,1-2H3
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n/an/an/an/a 1.50E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Group A streptococcus, GAS, streptokinase, expression, virulence, inhibition, dose response, EC50 Assay Overview: The goal of this assa...


PubChem Bioassay (2009)

More data for this
Ligand-Target Pair
streptokinase A precursor


(Streptococcus pyogenes M1 GAS)
BDBM58647
PNG
(MLS001077427 | SMR000708033 | [1-[[4-(3,4-difluoro...)
Show SMILES CC(OC(=O)C1CCC1)C(=O)Nc1nc(cs1)-c1ccc(F)c(F)c1
Show InChI InChI=1S/C17H16F2N2O3S/c1-9(24-16(23)10-3-2-4-10)15(22)21-17-20-14(8-25-17)11-5-6-12(18)13(19)7-11/h5-10H,2-4H2,1H3,(H,20,21,22)
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n/an/an/an/a 7.35E+4n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Group A streptococcus, GAS, streptokinase, expression, virulence, inhibition, dose response, EC50 Assay Overview: The goal of this assa...


PubChem Bioassay (2009)

More data for this
Ligand-Target Pair
streptokinase A precursor


(Streptococcus pyogenes M1 GAS)
BDBM58648
PNG
((2-benzamido-2-oxidanylidene-ethyl) 3-ethyl-5-meth...)
Show SMILES CCc1noc(C)c1C(=O)OCC(=O)NC(=O)c1ccccc1
Show InChI InChI=1S/C16H16N2O5/c1-3-12-14(10(2)23-18-12)16(21)22-9-13(19)17-15(20)11-7-5-4-6-8-11/h4-8H,3,9H2,1-2H3,(H,17,19,20)
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n/an/an/an/a 1.50E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Group A streptococcus, GAS, streptokinase, expression, virulence, inhibition, dose response, EC50 Assay Overview: The goal of this assa...


PubChem Bioassay (2009)

More data for this
Ligand-Target Pair
streptokinase A precursor


(Streptococcus pyogenes M1 GAS)
BDBM58649
PNG
(MLS001075726 | N'-[(E)-(5-ethoxy-6-keto-cyclohexa-...)
Show SMILES CCOc1cccc(C=NNC(=O)c2ccc3OCCOc3c2)c1O
Show InChI InChI=1S/C18H18N2O5/c1-2-23-15-5-3-4-13(17(15)21)11-19-20-18(22)12-6-7-14-16(10-12)25-9-8-24-14/h3-7,10-11,21H,2,8-9H2,1H3,(H,20,22)
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n/an/an/an/a 1.12E+3n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Group A streptococcus, GAS, streptokinase, expression, virulence, inhibition, dose response, EC50 Assay Overview: The goal of this assa...


PubChem Bioassay (2009)

More data for this
Ligand-Target Pair
streptokinase A precursor


(Streptococcus pyogenes M1 GAS)
BDBM58650
PNG
(2-[4-[(5Z)-5-(4-ethylbenzylidene)-4-keto-2-thioxo-...)
Show SMILES CCc1ccc(\C=C2/SC(=S)N(CCCC(=O)Nc3ccccc3C(O)=O)C2=O)cc1
Show InChI InChI=1S/C23H22N2O4S2/c1-2-15-9-11-16(12-10-15)14-19-21(27)25(23(30)31-19)13-5-8-20(26)24-18-7-4-3-6-17(18)22(28)29/h3-4,6-7,9-12,14H,2,5,8,13H2,1H3,(H,24,26)(H,28,29)/b19-14-
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n/an/an/an/a 5.00E+4n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Group A streptococcus, GAS, streptokinase, expression, virulence, inhibition, dose response, EC50 Assay Overview: The goal of this assa...


PubChem Bioassay (2009)

More data for this
Ligand-Target Pair
streptokinase A precursor


(Streptococcus pyogenes M1 GAS)
BDBM58651
PNG
(4-[4-[(5Z)-5-(4-ethylbenzylidene)-4-keto-2-thioxo-...)
Show SMILES CCc1ccc(\C=C2/SC(=S)N(CCCC(=O)Nc3ccc(cc3)C(O)=O)C2=O)cc1
Show InChI InChI=1S/C23H22N2O4S2/c1-2-15-5-7-16(8-6-15)14-19-21(27)25(23(30)31-19)13-3-4-20(26)24-18-11-9-17(10-12-18)22(28)29/h5-12,14H,2-4,13H2,1H3,(H,24,26)(H,28,29)/b19-14-
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n/an/an/an/a 1.50E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Group A streptococcus, GAS, streptokinase, expression, virulence, inhibition, dose response, EC50 Assay Overview: The goal of this assa...


PubChem Bioassay (2009)

More data for this
Ligand-Target Pair
streptokinase A precursor


(Streptococcus pyogenes M1 GAS)
BDBM58652
PNG
(MLS001075155 | N-[(o-toluoylamino)thiocarbamoyl]th...)
Show SMILES Cc1ccccc1C(=O)NNC(=S)NC(=O)c1cccs1
Show InChI InChI=1S/C14H13N3O2S2/c1-9-5-2-3-6-10(9)12(18)16-17-14(20)15-13(19)11-7-4-8-21-11/h2-8H,1H3,(H,16,18)(H2,15,17,19,20)
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n/an/an/an/a 1.50E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Group A streptococcus, GAS, streptokinase, expression, virulence, inhibition, dose response, EC50 Assay Overview: The goal of this assa...


PubChem Bioassay (2009)

More data for this
Ligand-Target Pair
streptokinase A precursor


(Streptococcus pyogenes M1 GAS)
BDBM58653
PNG
(MLS001074376 | N-[2-(3-phenyl-1-oxa-2,8-diazaspiro...)
Show SMILES CCCNC(=O)c1ccc(N2CCC3(CC(=NO3)c3ccccc3)CC2)c(NC(=O)c2ccco2)c1
Show InChI InChI=1S/C28H30N4O4/c1-2-14-29-26(33)21-10-11-24(22(18-21)30-27(34)25-9-6-17-35-25)32-15-12-28(13-16-32)19-23(31-36-28)20-7-4-3-5-8-20/h3-11,17-18H,2,12-16,19H2,1H3,(H,29,33)(H,30,34)
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n/an/an/an/a 1.50E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Group A streptococcus, GAS, streptokinase, expression, virulence, inhibition, dose response, EC50 Assay Overview: The goal of this assa...


PubChem Bioassay (2009)

More data for this
Ligand-Target Pair
streptokinase A precursor


(Streptococcus pyogenes M1 GAS)
BDBM58654
PNG
(2,2-dichloro-1-methyl-1-cyclopropanecarboxylic aci...)
Show SMILES CC1(CC1(Cl)Cl)C(=O)OCC(=O)Nc1nc(cs1)-c1ccc(F)c(F)c1
Show InChI InChI=1S/C16H12Cl2F2N2O3S/c1-15(7-16(15,17)18)13(24)25-5-12(23)22-14-21-11(6-26-14)8-2-3-9(19)10(20)4-8/h2-4,6H,5,7H2,1H3,(H,21,22,23)
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n/an/an/an/a 7.20E+3n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Group A streptococcus, GAS, streptokinase, expression, virulence, inhibition, dose response, EC50 Assay Overview: The goal of this assa...


PubChem Bioassay (2009)

More data for this
Ligand-Target Pair
streptokinase A precursor


(Streptococcus pyogenes M1 GAS)
BDBM58655
PNG
(2-(4-keto-3H-phthalazin-1-yl)acetic acid [2-[(5-ch...)
Show SMILES CC(OC(=O)Cc1n[nH]c(=O)c2ccccc12)C(=O)Nc1ccc(Cl)cn1
Show InChI InChI=1S/C18H15ClN4O4/c1-10(17(25)21-15-7-6-11(19)9-20-15)27-16(24)8-14-12-4-2-3-5-13(12)18(26)23-22-14/h2-7,9-10H,8H2,1H3,(H,23,26)(H,20,21,25)
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n/an/an/an/a 1.50E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Group A streptococcus, GAS, streptokinase, expression, virulence, inhibition, dose response, EC50 Assay Overview: The goal of this assa...


PubChem Bioassay (2009)

More data for this
Ligand-Target Pair
streptokinase A precursor


(Streptococcus pyogenes M1 GAS)
BDBM58656
PNG
(MLS001077422 | N-(1,1-diketothiolan-3-yl)-N-isobut...)
Show SMILES CC(C)CN(C1CCS(=O)(=O)C1)C(=O)COc1ccc(cc1)-c1nnco1
Show InChI InChI=1S/C18H23N3O5S/c1-13(2)9-21(15-7-8-27(23,24)11-15)17(22)10-25-16-5-3-14(4-6-16)18-20-19-12-26-18/h3-6,12-13,15H,7-11H2,1-2H3
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n/an/an/an/a 1.50E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Group A streptococcus, GAS, streptokinase, expression, virulence, inhibition, dose response, EC50 Assay Overview: The goal of this assa...


PubChem Bioassay (2009)

More data for this
Ligand-Target Pair
streptokinase A precursor


(Streptococcus pyogenes M1 GAS)
BDBM58657
PNG
(MLS001082707 | SMR000665799 | [3-(3,4-dimethylanil...)
Show SMILES COc1ccc(cc1F)C(=O)N1CCCC(C1)Nc1ccc(C)c(C)c1
Show InChI InChI=1S/C21H25FN2O2/c1-14-6-8-17(11-15(14)2)23-18-5-4-10-24(13-18)21(25)16-7-9-20(26-3)19(22)12-16/h6-9,11-12,18,23H,4-5,10,13H2,1-3H3
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n/an/an/an/a 1.50E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Group A streptococcus, GAS, streptokinase, expression, virulence, inhibition, dose response, EC50 Assay Overview: The goal of this assa...


PubChem Bioassay (2009)

More data for this
Ligand-Target Pair
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