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Compile Data Set for Download or QSAR

Found 81 hits Enz. Inhib. hit(s) with Target = 'thyroid beta' AND taxid = 10116   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
thyroid beta


(RAT)
BDBM86690
PNG
(A 348441 | A-348441)
Show SMILES CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]12C)c1ccc(cc1)N(C)CCO[C@H]1CCC2C(C1)C[C@@H](O)C1C3CCC(C(C)CCC(O)=O)C3[C@@H](O)CC21
Show InChI InChI=1S/C52H71NO7/c1-5-21-52(59)22-20-44-40-14-9-32-25-35(54)12-15-39(32)48(40)43(29-51(44,52)3)31-7-10-34(11-8-31)53(4)23-24-60-36-13-16-38-33(26-36)27-45(55)50-41-18-17-37(30(2)6-19-47(57)58)49(41)46(56)28-42(38)50/h7-8,10-11,25,30,33,36-38,40-46,49-50,55-56,59H,6,9,12-20,22-24,26-29H2,1-4H3,(H,57,58)/t30?,33?,36-,37?,38?,40-,41?,42?,43+,44-,45+,46-,49?,50?,51-,52-/m0/s1
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1.50E+3n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by PDSP Ki Database




J Pharmacol Exp Ther 314: 191-200 (2005)

More data for this
Ligand-Target Pair
thyroid beta


(RAT)
BDBM86689
PNG
(CAS_84371-65-3 | NSC_55245 | RU-486)
Show SMILES CC#CC1(O)CCC2C3CCC4=CC(=O)CCC4=C3C(CC12C)c1ccc(cc1)N(C)C
Show InChI InChI=1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,32H,8,11-14,16,18H2,1-4H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by PDSP Ki Database




J Pharmacol Exp Ther 314: 191-200 (2005)

More data for this
Ligand-Target Pair
thyroid beta


(RAT)
BDBM50036427
PNG
(CHEMBL350265 | [3,5-Dibromo-4-(4-hydroxy-3-isoprop...)
Show SMILES CC(C)c1cc(Oc2c(Br)cc(OCC(O)=O)cc2Br)ccc1O
Show InChI InChI=1S/C17H16Br2O5/c1-9(2)12-5-10(3-4-15(12)20)24-17-13(18)6-11(7-14(17)19)23-8-16(21)22/h3-7,9,20H,8H2,1-2H3,(H,21,22)
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n/an/a 0.100n/an/an/an/an/an/a



Ciba Pharmaceuticals

Curated by ChEMBL


Assay Description
Ability to inhibit the bound [125I]L-T3 rat liver Nuclear L-triiodothyronine receptor is determined in vitro.


J Med Chem 38: 695-707 (1995)

More data for this
Ligand-Target Pair
thyroid beta


(RAT)
BDBM50036401
PNG
(CHEMBL163221 | N-[4-(4-Hydroxy-3-isopropyl-phenoxy...)
Show SMILES CC(C)c1cc(Oc2c(I)cc(NC(=O)C(O)=O)cc2I)ccc1O
Show InChI InChI=1S/C17H15I2NO5/c1-8(2)11-7-10(3-4-14(11)21)25-15-12(18)5-9(6-13(15)19)20-16(22)17(23)24/h3-8,21H,1-2H3,(H,20,22)(H,23,24)
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n/an/a 0.100n/an/an/an/an/an/a



Ciba Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of the bound [125I]L-T3 rat liver nuclear L-triiodothyronine receptor


J Med Chem 38: 695-707 (1995)

More data for this
Ligand-Target Pair
thyroid beta


(RAT)
BDBM18865
PNG
(3-{3,5-dibromo-4-[4-hydroxy-3-(propan-2-yl)phenoxy...)
Show SMILES CC(C)c1cc(Oc2c(Br)cc(CCC(O)=O)cc2Br)ccc1O
Show InChI InChI=1S/C18H18Br2O4/c1-10(2)13-9-12(4-5-16(13)21)24-18-14(19)7-11(8-15(18)20)3-6-17(22)23/h4-5,7-10,21H,3,6H2,1-2H3,(H,22,23)
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n/an/a 0.110n/an/an/an/an/an/a



Ciba Pharmaceuticals

Curated by ChEMBL


Assay Description
Ability to inhibit the bound [125I]L-T3 rat liver Nuclear L-triiodothyronine receptor is determined in vitro.


J Med Chem 38: 695-707 (1995)

More data for this
Ligand-Target Pair
thyroid beta


(RAT)
BDBM18862
PNG
(2-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]ac...)
Show SMILES OC(=O)Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1
Show InChI InChI=1S/C14H9I3O4/c15-9-6-8(1-2-12(9)18)21-14-10(16)3-7(4-11(14)17)5-13(19)20/h1-4,6,18H,5H2,(H,19,20)
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n/an/a 0.150n/an/an/an/an/an/a



Ciba Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of the bound [125I]L-T3 rat liver nuclear L-triiodothyronine receptor


J Med Chem 38: 695-707 (1995)

More data for this
Ligand-Target Pair
thyroid beta


(RAT)
BDBM50036402
PNG
(CHEMBL46882 | N-[3,5-dimethyl-4-(4'-hydroxy-3'-iso...)
Show SMILES CC(C)c1cc(Oc2c(C)cc(NC(=O)C(O)=O)cc2C)ccc1O
Show InChI InChI=1S/C19H21NO5/c1-10(2)15-9-14(5-6-16(15)21)25-17-11(3)7-13(8-12(17)4)20-18(22)19(23)24/h5-10,21H,1-4H3,(H,20,22)(H,23,24)
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n/an/a 0.190n/an/an/an/an/an/a



Ciba Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of the bound [125I]L-T3 rat liver nuclear L-triiodothyronine receptor


J Med Chem 38: 695-707 (1995)

More data for this
Ligand-Target Pair
thyroid beta


(RAT)
BDBM50036399
PNG
(Axitirome | CHEMBL159682 | N-(4-{3-[(4-Fluoro-phen...)
Show SMILES CCOC(=O)C(=O)Nc1cc(C)c(Oc2ccc(O)c(c2)C(O)c2ccc(F)cc2)c(C)c1
Show InChI InChI=1S/C25H24FNO6/c1-4-32-25(31)24(30)27-18-11-14(2)23(15(3)12-18)33-19-9-10-21(28)20(13-19)22(29)16-5-7-17(26)8-6-16/h5-13,22,28-29H,4H2,1-3H3,(H,27,30)
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n/an/a 0.230n/an/an/an/an/an/a



Ciba Pharmaceuticals

Curated by ChEMBL


Assay Description
Ability to inhibit the bound [125I]L-T3 rat liver Nuclear L-triiodothyronine receptor is determined in vitro.


J Med Chem 38: 695-707 (1995)

More data for this
Ligand-Target Pair
thyroid beta


(RAT)
BDBM50036418
PNG
(CHEMBL350049 | N-[4-(4-Hydroxy-3-isopropyl-phenoxy...)
Show SMILES CCOC(=O)C(=O)Nc1cc(C)c(Oc2ccc(O)c(c2)C(C)C)c(C)c1
Show InChI InChI=1S/C21H25NO5/c1-6-26-21(25)20(24)22-15-9-13(4)19(14(5)10-15)27-16-7-8-18(23)17(11-16)12(2)3/h7-12,23H,6H2,1-5H3,(H,22,24)
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n/an/a 0.230n/an/an/an/an/an/a



Ciba Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of the bound [125I]L-T3 rat liver nuclear L-triiodothyronine receptor


J Med Chem 38: 695-707 (1995)

More data for this
Ligand-Target Pair
thyroid beta


(RAT)
BDBM50036423
PNG
(CHEMBL164421 | N-[4-(4-Hydroxy-3-isopropyl-phenoxy...)
Show SMILES CC(C)c1cc(Oc2c(C)cc(NC(=O)C(=O)OCc3ccccc3)cc2C)ccc1O
Show InChI InChI=1S/C26H27NO5/c1-16(2)22-14-21(10-11-23(22)28)32-24-17(3)12-20(13-18(24)4)27-25(29)26(30)31-15-19-8-6-5-7-9-19/h5-14,16,28H,15H2,1-4H3,(H,27,29)
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n/an/a 0.260n/an/an/an/an/an/a



Ciba Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of the bound [125I]L-T3 rat liver nuclear L-triiodothyronine receptor


J Med Chem 38: 695-707 (1995)

More data for this
Ligand-Target Pair
thyroid beta


(RAT)
BDBM50036411
PNG
(CHEMBL163324 | N-{3,5-Dichloro-4-[3-(4-chloro-benz...)
Show SMILES OC(=O)C(=O)Nc1cc(Cl)c(Oc2ccc(O)c(Cc3ccc(Cl)cc3)c2)c(Cl)c1
Show InChI InChI=1S/C21H14Cl3NO5/c22-13-3-1-11(2-4-13)7-12-8-15(5-6-18(12)26)30-19-16(23)9-14(10-17(19)24)25-20(27)21(28)29/h1-6,8-10,26H,7H2,(H,25,27)(H,28,29)
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n/an/a 0.270n/an/an/an/an/an/a



Ciba Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of the bound [125I]L-T3 rat liver nuclear L-triiodothyronine receptor


J Med Chem 38: 695-707 (1995)

More data for this
Ligand-Target Pair
thyroid beta


(RAT)
BDBM50036410
PNG
(CHEMBL159976 | [4-(4-Hydroxy-3-isopropyl-phenoxy)-...)
Show SMILES CC(C)c1cc(Oc2c(I)cc(NCC(O)=O)cc2I)ccc1O
Show InChI InChI=1S/C17H17I2NO4/c1-9(2)12-7-11(3-4-15(12)21)24-17-13(18)5-10(6-14(17)19)20-8-16(22)23/h3-7,9,20-21H,8H2,1-2H3,(H,22,23)
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n/an/a 0.310n/an/an/an/an/an/a



Ciba Pharmaceuticals

Curated by ChEMBL


Assay Description
Ability to inhibit the bound [125I]L-T3 rat liver Nuclear L-triiodothyronine receptor is determined in vitro.


J Med Chem 38: 695-707 (1995)

More data for this
Ligand-Target Pair
thyroid beta


(RAT)
BDBM50036424
PNG
(CHEMBL159334 | N-{3,5-Dichloro-4-[3-(4-fluoro-benz...)
Show SMILES OC(=O)C(=O)Nc1cc(Cl)c(Oc2ccc(O)c(c2)C(=O)c2ccc(F)cc2)c(Cl)c1
Show InChI InChI=1S/C21H12Cl2FNO6/c22-15-7-12(25-20(28)21(29)30)8-16(23)19(15)31-13-5-6-17(26)14(9-13)18(27)10-1-3-11(24)4-2-10/h1-9,26H,(H,25,28)(H,29,30)
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n/an/a 0.370n/an/an/an/an/an/a



Ciba Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of the bound [125I]L-T3 rat liver nuclear L-triiodothyronine receptor


J Med Chem 38: 695-707 (1995)

More data for this
Ligand-Target Pair
thyroid beta


(RAT)
BDBM50036408
PNG
(CHEMBL161828 | N-{4-[3-(4-Chloro-benzyl)-4-hydroxy...)
Show SMILES Cc1cc(NC(=O)C(O)=O)cc(C)c1Oc1ccc(O)c(Cc2ccc(Cl)cc2)c1
Show InChI InChI=1S/C23H20ClNO5/c1-13-9-18(25-22(27)23(28)29)10-14(2)21(13)30-19-7-8-20(26)16(12-19)11-15-3-5-17(24)6-4-15/h3-10,12,26H,11H2,1-2H3,(H,25,27)(H,28,29)
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n/an/a 0.430n/an/an/an/an/an/a



Ciba Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of the bound [125I]L-T3 rat liver nuclear L-triiodothyronine receptor


J Med Chem 38: 695-707 (1995)

More data for this
Ligand-Target Pair
thyroid beta


(RAT)
BDBM50036417
PNG
(CHEMBL423977 | N-{3,5-Dichloro-4-[3-(4-fluoro-benz...)
Show SMILES OC(=O)C(=O)Nc1cc(Cl)c(Oc2ccc(O)c(Cc3ccc(F)cc3)c2)c(Cl)c1
Show InChI InChI=1S/C21H14Cl2FNO5/c22-16-9-14(25-20(27)21(28)29)10-17(23)19(16)30-15-5-6-18(26)12(8-15)7-11-1-3-13(24)4-2-11/h1-6,8-10,26H,7H2,(H,25,27)(H,28,29)
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n/an/a 0.680n/an/an/an/an/an/a



Ciba Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of the bound [125I]L-T3 rat liver nuclear L-triiodothyronine receptor


J Med Chem 38: 695-707 (1995)

More data for this
Ligand-Target Pair
thyroid beta


(RAT)
BDBM50036417
PNG
(CHEMBL423977 | N-{3,5-Dichloro-4-[3-(4-fluoro-benz...)
Show SMILES OC(=O)C(=O)Nc1cc(Cl)c(Oc2ccc(O)c(Cc3ccc(F)cc3)c2)c(Cl)c1
Show InChI InChI=1S/C21H14Cl2FNO5/c22-16-9-14(25-20(27)21(28)29)10-17(23)19(16)30-15-5-6-18(26)12(8-15)7-11-1-3-13(24)4-2-11/h1-6,8-10,26H,7H2,(H,25,27)(H,28,29)
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n/an/a 0.680n/an/an/an/an/an/a



Ciba Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of the bound [125I]L-T3 rat liver nuclear L-triiodothyronine receptor


J Med Chem 38: 695-707 (1995)

More data for this
Ligand-Target Pair
thyroid beta


(RAT)
BDBM50036404
PNG
(CHEMBL159595 | N-(4-{3-[(4-Fluoro-phenyl)-hydroxy-...)
Show SMILES Cc1cc(NC(=O)C(O)=O)cc(C)c1Oc1ccc(O)c(c1)C(O)c1ccc(F)cc1
Show InChI InChI=1S/C23H20FNO6/c1-12-9-16(25-22(28)23(29)30)10-13(2)21(12)31-17-7-8-19(26)18(11-17)20(27)14-3-5-15(24)6-4-14/h3-11,20,26-27H,1-2H3,(H,25,28)(H,29,30)
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n/an/a 0.800n/an/an/an/an/an/a



Ciba Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of the bound [125I]L-T3 rat liver nuclear L-triiodothyronine receptor


J Med Chem 38: 695-707 (1995)

More data for this
Ligand-Target Pair
thyroid beta


(RAT)
BDBM50036395
PNG
(CHEMBL350199 | N-[4-(4-Hydroxy-3-isopropyl-phenoxy...)
Show SMILES CC(C)c1cc(Oc2c(C)cc(NC(=O)C(N)=O)cc2C)ccc1O
Show InChI InChI=1S/C19H22N2O4/c1-10(2)15-9-14(5-6-16(15)22)25-17-11(3)7-13(8-12(17)4)21-19(24)18(20)23/h5-10,22H,1-4H3,(H2,20,23)(H,21,24)
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n/an/a 0.950n/an/an/an/an/an/a



Ciba Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of the bound [125I]L-T3 rat liver nuclear L-triiodothyronine receptor


J Med Chem 38: 695-707 (1995)

More data for this
Ligand-Target Pair
thyroid beta


(RAT)
BDBM50036420
PNG
(CHEMBL161535 | N-[4-(3-Isopropyl-4-methoxy-phenoxy...)
Show SMILES COC(=O)C(=O)Nc1cc(C)c(Oc2ccc(OC)c(c2)C(C)C)c(C)c1
Show InChI InChI=1S/C21H25NO5/c1-12(2)17-11-16(7-8-18(17)25-5)27-19-13(3)9-15(10-14(19)4)22-20(23)21(24)26-6/h7-12H,1-6H3,(H,22,23)
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n/an/a 1n/an/an/an/an/an/a



Ciba Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of the bound [125I]L-T3 rat liver nuclear L-triiodothyronine receptor


J Med Chem 38: 695-707 (1995)

More data for this
Ligand-Target Pair
thyroid beta


(RAT)
BDBM50036397
PNG
(CHEMBL348983 | N-[3,5-Dichloro-4-(4-hydroxy-3-isop...)
Show SMILES CC(C)c1cc(Oc2c(Cl)cc(NC(=O)C(O)=O)cc2Cl)ccc1O
Show InChI InChI=1S/C17H15Cl2NO5/c1-8(2)11-7-10(3-4-14(11)21)25-15-12(18)5-9(6-13(15)19)20-16(22)17(23)24/h3-8,21H,1-2H3,(H,20,22)(H,23,24)
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n/an/a 1.10n/an/an/an/an/an/a



Ciba Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of the bound [125I]L-T3 rat liver nuclear L-triiodothyronine receptor


J Med Chem 38: 695-707 (1995)

More data for this
Ligand-Target Pair
thyroid beta


(RAT)
BDBM50036406
PNG
(CHEMBL163380 | [3,5-Dichloro-4-(4-hydroxy-3-isopro...)
Show SMILES CC(C)c1cc(Oc2c(Cl)cc(NCC(O)=O)cc2Cl)ccc1O
Show InChI InChI=1S/C17H17Cl2NO4/c1-9(2)12-7-11(3-4-15(12)21)24-17-13(18)5-10(6-14(17)19)20-8-16(22)23/h3-7,9,20-21H,8H2,1-2H3,(H,22,23)
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n/an/a 1.10n/an/an/an/an/an/a



Ciba Pharmaceuticals

Curated by ChEMBL


Assay Description
Ability to inhibit the bound [125I]L-T3 rat liver Nuclear L-triiodothyronine receptor is determined in vitro.


J Med Chem 38: 695-707 (1995)

More data for this
Ligand-Target Pair
thyroid beta


(RAT)
BDBM50036398
PNG
(CHEMBL162692 | [3,5-Dibromo-4-(4-hydroxy-3-isoprop...)
Show SMILES CC(C)c1cc(Oc2c(Br)cc(SCC(O)=O)cc2Br)ccc1O
Show InChI InChI=1S/C17H16Br2O4S/c1-9(2)12-5-10(3-4-15(12)20)23-17-13(18)6-11(7-14(17)19)24-8-16(21)22/h3-7,9,20H,8H2,1-2H3,(H,21,22)
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n/an/a 1.5n/an/an/an/an/an/a



Ciba Pharmaceuticals

Curated by ChEMBL


Assay Description
Ability to inhibit the bound [125I]L-T3 rat liver Nuclear L-triiodothyronine receptor is determined in vitro.


J Med Chem 38: 695-707 (1995)

More data for this
Ligand-Target Pair
thyroid beta


(RAT)
BDBM50036405
PNG
(CHEMBL434476 | N-(3,5-Dichloro-4-{3-[(4-chloro-phe...)
Show SMILES OC(c1ccc(Cl)cc1)c1cc(Oc2c(Cl)cc(NC(=O)C(O)=O)cc2Cl)ccc1O
Show InChI InChI=1S/C21H14Cl3NO6/c22-11-3-1-10(2-4-11)18(27)14-9-13(5-6-17(14)26)31-19-15(23)7-12(8-16(19)24)25-20(28)21(29)30/h1-9,18,26-27H,(H,25,28)(H,29,30)
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n/an/a 1.5n/an/an/an/an/an/a



Ciba Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of the bound [125I]L-T3 rat liver nuclear L-triiodothyronine receptor


J Med Chem 38: 695-707 (1995)

More data for this
Ligand-Target Pair
thyroid beta


(RAT)
BDBM18860
PNG
((2R)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-di...)
Show SMILES N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C(O)=O
Show InChI InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1
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n/an/a 1.80n/an/an/an/an/an/a



Ciba Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of the bound [125I]L-T3 rat liver nuclear L-triiodothyronine receptor


J Med Chem 38: 695-707 (1995)

More data for this
Ligand-Target Pair
thyroid beta


(RAT)
BDBM50036426
PNG
(CHEMBL159610 | N-{4-[3-(4-Fluoro-benzoyl)-4-hydrox...)
Show SMILES Cc1cc(NC(=O)C(O)=O)cc(C)c1Oc1ccc(O)c(c1)C(=O)c1ccc(F)cc1
Show InChI InChI=1S/C23H18FNO6/c1-12-9-16(25-22(28)23(29)30)10-13(2)21(12)31-17-7-8-19(26)18(11-17)20(27)14-3-5-15(24)6-4-14/h3-11,26H,1-2H3,(H,25,28)(H,29,30)
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n/an/a 2.5n/an/an/an/an/an/a



Ciba Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of the bound [125I]L-T3 rat liver nuclear L-triiodothyronine receptor


J Med Chem 38: 695-707 (1995)

More data for this
Ligand-Target Pair
thyroid beta


(RAT)
BDBM50036415
PNG
(CHEMBL163268 | N-[3,5-Dibromo-4-(4-hydroxy-3-isopr...)
Show SMILES CC(C)c1cc(Oc2c(Br)cc(NC(=O)C(N)=O)cc2Br)ccc1O
Show InChI InChI=1S/C17H16Br2N2O4/c1-8(2)11-7-10(3-4-14(11)22)25-15-12(18)5-9(6-13(15)19)21-17(24)16(20)23/h3-8,22H,1-2H3,(H2,20,23)(H,21,24)
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n/an/a 3n/an/an/an/an/an/a



Ciba Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of the bound [125I]L-T3 rat liver nuclear L-triiodothyronine receptor


J Med Chem 38: 695-707 (1995)

More data for this
Ligand-Target Pair
thyroid beta


(RAT)
BDBM50036414
PNG
(CHEMBL346112 | N-{4-[3-(4-Chloro-benzoyl)-4-hydrox...)
Show SMILES Cc1cc(NC(=O)C(O)=O)cc(C)c1Oc1ccc(O)c(c1)C(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H18ClNO6/c1-12-9-16(25-22(28)23(29)30)10-13(2)21(12)31-17-7-8-19(26)18(11-17)20(27)14-3-5-15(24)6-4-14/h3-11,26H,1-2H3,(H,25,28)(H,29,30)
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n/an/a 3.30n/an/an/an/an/an/a



Ciba Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of the bound [125I]L-T3 rat liver nuclear L-triiodothyronine receptor


J Med Chem 38: 695-707 (1995)

More data for this
Ligand-Target Pair
thyroid beta


(RAT)
BDBM50036430
PNG
(CHEMBL347713 | [4-(4-Hydroxy-3-isopropyl-phenoxy)-...)
Show SMILES CC(C)c1cc(Oc2c(C)cc(SCC(O)=O)cc2C)ccc1O
Show InChI InChI=1S/C19H22O4S/c1-11(2)16-9-14(5-6-17(16)20)23-19-12(3)7-15(8-13(19)4)24-10-18(21)22/h5-9,11,20H,10H2,1-4H3,(H,21,22)
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n/an/a 3.5n/an/an/an/an/an/a



Ciba Pharmaceuticals

Curated by ChEMBL


Assay Description
Ability to inhibit the bound [125I]L-T3 rat liver Nuclear L-triiodothyronine receptor is determined in vitro.


J Med Chem 38: 695-707 (1995)

More data for this
Ligand-Target Pair
thyroid beta


(RAT)
BDBM50036422
PNG
(CHEMBL163020 | N-[3,5-Difluoro-4-(4-hydroxy-3-isop...)
Show SMILES CC(C)c1cc(Oc2c(F)cc(NC(=O)C(O)=O)cc2F)ccc1O
Show InChI InChI=1S/C17H15F2NO5/c1-8(2)11-7-10(3-4-14(11)21)25-15-12(18)5-9(6-13(15)19)20-16(22)17(23)24/h3-8,21H,1-2H3,(H,20,22)(H,23,24)
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n/an/a 3.60n/an/an/an/an/an/a



Ciba Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of the bound [125I]L-T3 rat liver nuclear L-triiodothyronine receptor


J Med Chem 38: 695-707 (1995)

More data for this
Ligand-Target Pair
thyroid beta


(RAT)
BDBM50036409
PNG
((S)-2-Amino-3-[3,5-dibromo-4-(4-hydroxy-3-isopropy...)
Show SMILES CC(C)c1cc(Oc2c(Br)cc(C[C@H](N)C(O)=O)cc2Br)ccc1O
Show InChI InChI=1S/C18H19Br2NO4/c1-9(2)12-8-11(3-4-16(12)22)25-17-13(19)5-10(6-14(17)20)7-15(21)18(23)24/h3-6,8-9,15,22H,7,21H2,1-2H3,(H,23,24)/t15-/m0/s1
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n/an/a 4.5n/an/an/an/an/an/a



Ciba Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of the bound [125I]L-T3 rat liver nuclear L-triiodothyronine receptor


J Med Chem 38: 695-707 (1995)

More data for this
Ligand-Target Pair
thyroid beta


(RAT)
BDBM50036396
PNG
(CHEMBL163320 | N-[3,5-Dibromo-4-(4-hydroxy-3-isopr...)
Show SMILES CC(C)c1cc(Oc2c(Br)cc(NC(=O)C(O)=O)cc2Br)ccc1O
Show InChI InChI=1S/C17H15Br2NO5/c1-8(2)11-7-10(3-4-14(11)21)25-15-12(18)5-9(6-13(15)19)20-16(22)17(23)24/h3-8,21H,1-2H3,(H,20,22)(H,23,24)
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n/an/a 6n/an/an/an/an/an/a



Ciba Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of the bound [125I]L-T3 rat liver nuclear L-triiodothyronine receptor


J Med Chem 38: 695-707 (1995)

More data for this
Ligand-Target Pair
thyroid beta


(RAT)
BDBM50036432
PNG
(CHEMBL264041 | N-[4-(3-Isopropyl-phenoxy)-3,5-dime...)
Show SMILES COC(=O)C(=O)Nc1cc(C)c(Oc2cccc(c2)C(C)C)c(C)c1
Show InChI InChI=1S/C20H23NO4/c1-12(2)15-7-6-8-17(11-15)25-18-13(3)9-16(10-14(18)4)21-19(22)20(23)24-5/h6-12H,1-5H3,(H,21,22)
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n/an/a 8n/an/an/an/an/an/a



Ciba Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of the bound [125I]L-T3 rat liver nuclear L-triiodothyronine receptor


J Med Chem 38: 695-707 (1995)

More data for this
Ligand-Target Pair
thyroid beta


(RAT)
BDBM50036403
PNG
(CHEMBL352126 | [4-(4-Hydroxy-3-isopropyl-phenoxy)-...)
Show SMILES CC(C)c1cc(Oc2c(C)cc(NCC(O)=O)cc2C)ccc1O
Show InChI InChI=1S/C19H23NO4/c1-11(2)16-9-15(5-6-17(16)21)24-19-12(3)7-14(8-13(19)4)20-10-18(22)23/h5-9,11,20-21H,10H2,1-4H3,(H,22,23)
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n/an/a 12n/an/an/an/an/an/a



Ciba Pharmaceuticals

Curated by ChEMBL


Assay Description
Ability to inhibit the bound [125I]L-T3 rat liver Nuclear L-triiodothyronine receptor is determined in vitro.


J Med Chem 38: 695-707 (1995)

More data for this
Ligand-Target Pair
thyroid beta


(RAT)
BDBM50036412
PNG
(CHEMBL161245 | N-[4-(3-Isopropyl-4-methoxy-phenoxy...)
Show SMILES COc1ccc(Oc2c(C)cc(NC(=O)C(O)=O)cc2C)cc1C(C)C
Show InChI InChI=1S/C20H23NO5/c1-11(2)16-10-15(6-7-17(16)25-5)26-18-12(3)8-14(9-13(18)4)21-19(22)20(23)24/h6-11H,1-5H3,(H,21,22)(H,23,24)
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n/an/a 14n/an/an/an/an/an/a



Ciba Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of the bound [125I]L-T3 rat liver nuclear L-triiodothyronine receptor


J Med Chem 38: 695-707 (1995)

More data for this
Ligand-Target Pair
thyroid beta


(RAT)
BDBM50036407
PNG
(CHEMBL441101 | N-[4-(4-Hydroxy-3-isopropyl-phenoxy...)
Show SMILES CC(C)c1cc(Oc2c(cc(NC(=O)C(O)=O)cc2C(C)C)C(C)C)ccc1O
Show InChI InChI=1S/C23H29NO5/c1-12(2)17-11-16(7-8-20(17)25)29-21-18(13(3)4)9-15(10-19(21)14(5)6)24-22(26)23(27)28/h7-14,25H,1-6H3,(H,24,26)(H,27,28)
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n/an/a 22n/an/an/an/an/an/a



Ciba Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of the bound [125I]L-T3 rat liver nuclear L-triiodothyronine receptor


J Med Chem 38: 695-707 (1995)

More data for this
Ligand-Target Pair
thyroid beta


(RAT)
BDBM50036394
PNG
(CHEMBL163611 | N-(4-{3-[(4-Fluoro-phenyl)-hydroxy-...)
Show SMILES CCOC(=O)C(=O)Nc1cc(C)c(Oc2ccc(OC)c(c2)C(O)c2ccc(F)cc2)c(C)c1
Show InChI InChI=1S/C26H26FNO6/c1-5-33-26(31)25(30)28-19-12-15(2)24(16(3)13-19)34-20-10-11-22(32-4)21(14-20)23(29)17-6-8-18(27)9-7-17/h6-14,23,29H,5H2,1-4H3,(H,28,30)
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n/an/a 34n/an/an/an/an/an/a



Ciba Pharmaceuticals

Curated by ChEMBL


Assay Description
Ability to inhibit the bound [125I]L-T3 rat liver Nuclear L-triiodothyronine receptor is determined in vitro.


J Med Chem 38: 695-707 (1995)

More data for this
Ligand-Target Pair
thyroid beta


(RAT)
BDBM50225220
PNG
(CHEMBL559 | D-thyroxine | O-(4-hydroxy-3,5-diiodop...)
Show SMILES N[C@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(O)=O
Show InChI InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m1/s1
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n/an/a 35n/an/an/an/an/an/a



Ciba Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of the bound [125I]L-T3 rat liver nuclear L-triiodothyronine receptor


J Med Chem 38: 695-707 (1995)

More data for this
Ligand-Target Pair
thyroid beta


(RAT)
BDBM50036413
PNG
(CHEMBL163283 | N-[3,5-Dibromo-4-(4-hydroxy-3-isopr...)
Show SMILES CNC(=O)C(=O)Nc1cc(Br)c(Oc2ccc(O)c(c2)C(C)C)c(Br)c1
Show InChI InChI=1S/C18H18Br2N2O4/c1-9(2)12-8-11(4-5-15(12)23)26-16-13(19)6-10(7-14(16)20)22-18(25)17(24)21-3/h4-9,23H,1-3H3,(H,21,24)(H,22,25)
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n/an/a 47n/an/an/an/an/an/a



Ciba Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of the bound [125I]L-T3 rat liver nuclear L-triiodothyronine receptor


J Med Chem 38: 695-707 (1995)

More data for this
Ligand-Target Pair
thyroid beta


(RAT)
BDBM50036431
PNG
(2-[3,5-Dichloro-4-(4-hydroxy-3-isopropyl-phenoxy)-...)
Show SMILES CC(C)c1cc(Oc2c(Cl)cc(NC(C)C(O)=O)cc2Cl)ccc1O
Show InChI InChI=1S/C18H19Cl2NO4/c1-9(2)13-8-12(4-5-16(13)22)25-17-14(19)6-11(7-15(17)20)21-10(3)18(23)24/h4-10,21-22H,1-3H3,(H,23,24)
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Ciba Pharmaceuticals

Curated by ChEMBL


Assay Description
Ability to inhibit the bound [125I]L-T3 rat liver Nuclear L-triiodothyronine receptor is determined in vitro.


J Med Chem 38: 695-707 (1995)

More data for this
Ligand-Target Pair
thyroid beta


(RAT)
BDBM50036421
PNG
((S)-2-Amino-3-{3,5-dibromo-4-[4-hydroxy-3-(6-oxo-1...)
Show SMILES N[C@@H](Cc1cc(Br)c(Oc2ccc(O)c(Cc3ccc(=O)[nH]n3)c2)c(Br)c1)C(O)=O
Show InChI InChI=1S/C20H17Br2N3O5/c21-14-5-10(7-16(23)20(28)29)6-15(22)19(14)30-13-2-3-17(26)11(9-13)8-12-1-4-18(27)25-24-12/h1-6,9,16,26H,7-8,23H2,(H,25,27)(H,28,29)/t16-/m0/s1
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Ciba Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of the bound [125I]L-T3 rat liver nuclear L-triiodothyronine receptor


J Med Chem 38: 695-707 (1995)

More data for this
Ligand-Target Pair
thyroid beta


(RAT)
BDBM50036393
PNG
(CHEMBL350336 | N-[4-(4-Hydroxy-3-isopropyl-phenoxy...)
Show SMILES CC(C)c1cc(Oc2ccc(NC(=O)C(O)=O)cc2)ccc1O
Show InChI InChI=1S/C17H17NO5/c1-10(2)14-9-13(7-8-15(14)19)23-12-5-3-11(4-6-12)18-16(20)17(21)22/h3-10,19H,1-2H3,(H,18,20)(H,21,22)
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Ciba Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of the bound [125I]L-T3 rat liver nuclear L-triiodothyronine receptor


J Med Chem 38: 695-707 (1995)

More data for this
Ligand-Target Pair
thyroid beta


(RAT)
BDBM50036428
PNG
(CHEMBL163518 | N-{3,5-Dichloro-4-[3-(4-chloro-benz...)
Show SMILES OC(=O)C(=O)Nc1cc(Cl)c(Oc2ccc(O)c(c2)C(=O)c2ccc(Cl)cc2)c(Cl)c1
Show InChI InChI=1S/C21H12Cl3NO6/c22-11-3-1-10(2-4-11)18(27)14-9-13(5-6-17(14)26)31-19-15(23)7-12(8-16(19)24)25-20(28)21(29)30/h1-9,26H,(H,25,28)(H,29,30)
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n/an/a 52n/an/an/an/an/an/a



Ciba Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of the bound [125I]L-T3 rat liver nuclear L-triiodothyronine receptor


J Med Chem 38: 695-707 (1995)

More data for this
Ligand-Target Pair
thyroid beta


(RAT)
BDBM50036425
PNG
(2-[3,5-Dichloro-4-(4-hydroxy-3-isopropyl-phenoxy)-...)
Show SMILES CC(C)c1cc(Oc2c(Cl)cc(NC(Cc3ccccc3)C(O)=O)cc2Cl)ccc1O
Show InChI InChI=1S/C24H23Cl2NO4/c1-14(2)18-13-17(8-9-22(18)28)31-23-19(25)11-16(12-20(23)26)27-21(24(29)30)10-15-6-4-3-5-7-15/h3-9,11-14,21,27-28H,10H2,1-2H3,(H,29,30)
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Ciba Pharmaceuticals

Curated by ChEMBL


Assay Description
Ability to inhibit the bound [125I]L-T3 rat liver Nuclear L-triiodothyronine receptor is determined in vitro.


J Med Chem 38: 695-707 (1995)

More data for this
Ligand-Target Pair
thyroid beta


(RAT)
BDBM50036419
PNG
(CHEMBL163805 | N-[4-(4-Hydroxy-3-isopropyl-phenoxy...)
Show SMILES CC(C)c1cc(Oc2c(C)cc(cc2C)N(C)C(=O)C(O)=O)ccc1O
Show InChI InChI=1S/C20H23NO5/c1-11(2)16-10-15(6-7-17(16)22)26-18-12(3)8-14(9-13(18)4)21(5)19(23)20(24)25/h6-11,22H,1-5H3,(H,24,25)
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n/an/a 120n/an/an/an/an/an/a



Ciba Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of the bound [125I]L-T3 rat liver nuclear L-triiodothyronine receptor


J Med Chem 38: 695-707 (1995)

More data for this
Ligand-Target Pair
thyroid beta


(RAT)
BDBM50036409
PNG
((S)-2-Amino-3-[3,5-dibromo-4-(4-hydroxy-3-isopropy...)
Show SMILES CC(C)c1cc(Oc2c(Br)cc(C[C@H](N)C(O)=O)cc2Br)ccc1O
Show InChI InChI=1S/C18H19Br2NO4/c1-9(2)12-8-11(3-4-16(12)22)25-17-13(19)5-10(6-14(17)20)7-15(21)18(23)24/h3-6,8-9,15,22H,7,21H2,1-2H3,(H,23,24)/t15-/m0/s1
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n/an/a 200n/an/an/an/an/an/a



Ciba Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of bound [125I]L-T3 rat plasma membrane 3,5,3'' L-triiodothyronine receptor


J Med Chem 38: 695-707 (1995)

More data for this
Ligand-Target Pair
thyroid beta


(RAT)
BDBM50036416
PNG
(2-[4-(4-Hydroxy-3-isopropyl-phenoxy)-3,5-dimethyl-...)
Show SMILES CC(C)c1cc(Oc2c(C)cc(NC(Cc3ccccc3)C(O)=O)cc2C)ccc1O
Show InChI InChI=1S/C26H29NO4/c1-16(2)22-15-21(10-11-24(22)28)31-25-17(3)12-20(13-18(25)4)27-23(26(29)30)14-19-8-6-5-7-9-19/h5-13,15-16,23,27-28H,14H2,1-4H3,(H,29,30)
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n/an/a 400n/an/an/an/an/an/a



Ciba Pharmaceuticals

Curated by ChEMBL


Assay Description
Ability to inhibit the bound [125I]L-T3 rat liver Nuclear L-triiodothyronine receptor is determined in vitro.


J Med Chem 38: 695-707 (1995)

More data for this
Ligand-Target Pair
thyroid beta


(RAT)
BDBM18860
PNG
((2R)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-di...)
Show SMILES N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C(O)=O
Show InChI InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1
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Ciba Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of bound [125I]L-T3 rat plasma membrane 3,5,3'' L-triiodothyronine receptor


J Med Chem 38: 695-707 (1995)

More data for this
Ligand-Target Pair
thyroid beta


(RAT)
BDBM18860
PNG
((2R)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-di...)
Show SMILES N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C(O)=O
Show InChI InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1
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Ciba Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of bound [125I]L-T3 rat plasma membrane 3,5,3'' L-triiodothyronine receptor


J Med Chem 38: 695-707 (1995)

More data for this
Ligand-Target Pair
thyroid beta


(RAT)
BDBM50036429
PNG
(2-[4-(4-Hydroxy-3-isopropyl-phenoxy)-3,5-dimethyl-...)
Show SMILES CC(C)c1cc(Oc2c(C)cc(NC(C)C(O)=O)cc2C)ccc1O
Show InChI InChI=1S/C20H25NO4/c1-11(2)17-10-16(6-7-18(17)22)25-19-12(3)8-15(9-13(19)4)21-14(5)20(23)24/h6-11,14,21-22H,1-5H3,(H,23,24)
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n/an/a 550n/an/an/an/an/an/a



Ciba Pharmaceuticals

Curated by ChEMBL


Assay Description
Ability to inhibit the bound [125I]L-T3 rat liver Nuclear L-triiodothyronine receptor is determined in vitro.


J Med Chem 38: 695-707 (1995)

More data for this
Ligand-Target Pair
thyroid beta


(RAT)
BDBM50036410
PNG
(CHEMBL159976 | [4-(4-Hydroxy-3-isopropyl-phenoxy)-...)
Show SMILES CC(C)c1cc(Oc2c(I)cc(NCC(O)=O)cc2I)ccc1O
Show InChI InChI=1S/C17H17I2NO4/c1-9(2)12-7-11(3-4-15(12)21)24-17-13(18)5-10(6-14(17)19)20-8-16(22)23/h3-7,9,20-21H,8H2,1-2H3,(H,22,23)
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Ciba Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of bound [125I]L-T3 rat plasma membrane 3,5,3'' L-triiodothyronine receptor


J Med Chem 38: 695-707 (1995)

More data for this
Ligand-Target Pair
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