BindingDB logo
myBDB logout

Patent code US10000476

Compile Data Set for Download or QSAR

Found 229 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
ADAM17


(Homo sapiens (Human))
BDBM400649
PNG
(US10000476, Compound I-8)
Show SMILES Cc1cccn(CC2(NC(=O)NC2=O)c2cccnc2)c1=O
Show InChI InChI=1S/C15H14N4O3/c1-10-4-3-7-19(12(10)20)9-15(11-5-2-6-16-8-11)13(21)17-14(22)18-15/h2-8H,9H2,1H3,(H2,17,18,21,22)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



KAKEN PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)

More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM400669
PNG
(US10000476, Compound I-28)
Show SMILES Cc1cccn(CC2(NC(=O)NC2=O)c2cccc(F)c2)c1=O
Show InChI InChI=1S/C16H14FN3O3/c1-10-4-3-7-20(13(10)21)9-16(14(22)18-15(23)19-16)11-5-2-6-12(17)8-11/h2-8H,9H2,1H3,(H2,18,19,22,23)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



KAKEN PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)

More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM400675
PNG
(US10000476, Compound I-34)
Show SMILES Cc1ccc(Oc2ccc(cc2)C2(Cn3cccc(C)c3=O)NC(=O)NC2=O)cc1
Show InChI InChI=1S/C23H21N3O4/c1-15-5-9-18(10-6-15)30-19-11-7-17(8-12-19)23(21(28)24-22(29)25-23)14-26-13-3-4-16(2)20(26)27/h3-13H,14H2,1-2H3,(H2,24,25,28,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



KAKEN PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)

More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM400685
PNG
(US10000476, Compound I-44)
Show SMILES Cc1cccn(CC2(NC(=O)NC2=O)c2cc(F)c(F)c(F)c2)c1=O
Show InChI InChI=1S/C16H12F3N3O3/c1-8-3-2-4-22(13(8)23)7-16(14(24)20-15(25)21-16)9-5-10(17)12(19)11(18)6-9/h2-6H,7H2,1H3,(H2,20,21,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



KAKEN PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)

More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM400686
PNG
(US10000476, Compound I-45)
Show SMILES CCCc1ccc(cc1)C1(Cn2cccc(C)c2=O)NC(=O)NC1=O
Show InChI InChI=1S/C19H21N3O3/c1-3-5-14-7-9-15(10-8-14)19(17(24)20-18(25)21-19)12-22-11-4-6-13(2)16(22)23/h4,6-11H,3,5,12H2,1-2H3,(H2,20,21,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



KAKEN PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)

More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM400687
PNG
(US10000476, Compound I-46)
Show SMILES O=C1NC(=O)C(Cn2ccccc2=O)(N1)c1ccccc1
Show InChI InChI=1S/C15H13N3O3/c19-12-8-4-5-9-18(12)10-15(11-6-2-1-3-7-11)13(20)16-14(21)17-15/h1-9H,10H2,(H2,16,17,20,21)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



KAKEN PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)

More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM400690
PNG
(US10000476, Compound I-49)
Show SMILES Fc1cccn(CC2(NC(=O)NC2=O)c2ccc(cc2)-c2ccccc2)c1=O
Show InChI InChI=1S/C21H16FN3O3/c22-17-7-4-12-25(18(17)26)13-21(19(27)23-20(28)24-21)16-10-8-15(9-11-16)14-5-2-1-3-6-14/h1-12H,13H2,(H2,23,24,27,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



KAKEN PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)

More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM400703
PNG
(US10000476, Compound I-62)
Show SMILES Cc1cccn(CC2(NC(=O)NC2=O)c2cccc(c2)-c2cccnc2)c1=O
Show InChI InChI=1S/C21H18N4O3/c1-14-5-4-10-25(18(14)26)13-21(19(27)23-20(28)24-21)17-8-2-6-15(11-17)16-7-3-9-22-12-16/h2-12H,13H2,1H3,(H2,23,24,27,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



KAKEN PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)

More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM400719
PNG
(US10000476, Compound I-78)
Show SMILES Cc1cccn(CC2(NC(=O)NC2=O)c2ccc(OC(F)F)cc2)c1=O
Show InChI InChI=1S/C17H15F2N3O4/c1-10-3-2-8-22(13(10)23)9-17(14(24)20-16(25)21-17)11-4-6-12(7-5-11)26-15(18)19/h2-8,15H,9H2,1H3,(H2,20,21,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



KAKEN PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)

More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM400738
PNG
(US10000476, Compound I-97)
Show SMILES Cc1cccn(CC2(NC(=O)NC2=O)c2cccc(Oc3ccc(F)cc3F)c2)c1=O
Show InChI InChI=1S/C22H17F2N3O4/c1-13-4-3-9-27(19(13)28)12-22(20(29)25-21(30)26-22)14-5-2-6-16(10-14)31-18-8-7-15(23)11-17(18)24/h2-11H,12H2,1H3,(H2,25,26,29,30)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



KAKEN PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)

More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM400767
PNG
(US10000476, Compound I-126)
Show SMILES Cc1cccn(CC2(NC(=O)NC2=O)c2ccc(F)c(Cl)c2)c1=O
Show InChI InChI=1S/C16H13ClFN3O3/c1-9-3-2-6-21(13(9)22)8-16(14(23)19-15(24)20-16)10-4-5-12(18)11(17)7-10/h2-7H,8H2,1H3,(H2,19,20,23,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



KAKEN PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)

More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM400775
PNG
(US10000476, Compound I-134)
Show SMILES Fc1cccn(CC2(NC(=O)NC2=O)c2ccc(cc2)C#N)c1=O
Show InChI InChI=1S/C16H11FN4O3/c17-12-2-1-7-21(13(12)22)9-16(14(23)19-15(24)20-16)11-5-3-10(8-18)4-6-11/h1-7H,9H2,(H2,19,20,23,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



KAKEN PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)

More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM400776
PNG
(US10000476, Compound I-135)
Show SMILES Fc1cccn(CC2(NC(=O)NC2=O)c2ccc3ccccc3c2)c1=O
Show InChI InChI=1S/C19H14FN3O3/c20-15-6-3-9-23(16(15)24)11-19(17(25)21-18(26)22-19)14-8-7-12-4-1-2-5-13(12)10-14/h1-10H,11H2,(H2,21,22,25,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



KAKEN PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)

More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM400795
PNG
(US10000476, Compound I-154)
Show SMILES Cc1cccn(CC2(NC(=O)NC2=O)c2cc(F)cc(F)c2)c1=O
Show InChI InChI=1S/C16H13F2N3O3/c1-9-3-2-4-21(13(9)22)8-16(14(23)19-15(24)20-16)10-5-11(17)7-12(18)6-10/h2-7H,8H2,1H3,(H2,19,20,23,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



KAKEN PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)

More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM400652
PNG
(US10000476, Compound I-11)
Show SMILES Cc1cccn(CC2(NC(=O)NC2=O)c2ccc(Br)cc2)c1=O
Show InChI InChI=1S/C16H14BrN3O3/c1-10-3-2-8-20(13(10)21)9-16(14(22)18-15(23)19-16)11-4-6-12(17)7-5-11/h2-8H,9H2,1H3,(H2,18,19,22,23)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



KAKEN PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)

More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM400657
PNG
(US10000476, Compound I-16)
Show SMILES COc1ccc(cc1OC)C1(Cn2cccc(C)c2=O)NC(=O)NC1=O
Show InChI InChI=1S/C18H19N3O5/c1-11-5-4-8-21(15(11)22)10-18(16(23)19-17(24)20-18)12-6-7-13(25-2)14(9-12)26-3/h4-9H,10H2,1-3H3,(H2,19,20,23,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



KAKEN PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)

More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM400658
PNG
(US10000476, Compound I-17)
Show SMILES Cc1cccn(CC2(NC(=O)NC2=O)c2ccc(cc2)C(C)(C)C)c1=O
Show InChI InChI=1S/C20H23N3O3/c1-13-6-5-11-23(16(13)24)12-20(17(25)21-18(26)22-20)15-9-7-14(8-10-15)19(2,3)4/h5-11H,12H2,1-4H3,(H2,21,22,25,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



KAKEN PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)

More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM400679
PNG
(US10000476, Compound I-38)
Show SMILES Cc1cccn(CC2(NC(=O)NC2=O)C2(C)CC=C(OC3CCCC=C3)C=C2)c1=O
Show InChI InChI=1S/C23H27N3O4/c1-16-7-6-14-26(19(16)27)15-23(20(28)24-21(29)25-23)22(2)12-10-18(11-13-22)30-17-8-4-3-5-9-17/h4,6-8,10-12,14,17H,3,5,9,13,15H2,1-2H3,(H2,24,25,28,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



KAKEN PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)

More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM400715
PNG
(US10000476, Compound I-74)
Show SMILES COc1ccccc1-c1ccc(cc1)C1(Cn2cccc(C)c2=O)NC(=O)NC1=O
Show InChI InChI=1S/C23H21N3O4/c1-15-6-5-13-26(20(15)27)14-23(21(28)24-22(29)25-23)17-11-9-16(10-12-17)18-7-3-4-8-19(18)30-2/h3-13H,14H2,1-2H3,(H2,24,25,28,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



KAKEN PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)

More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM400725
PNG
(US10000476, Compound I-84)
Show SMILES Cc1cccn(CC2(NC(=O)NC2=O)c2ccc(Oc3cccc(F)c3)cc2)c1=O
Show InChI InChI=1S/C22H18FN3O4/c1-14-4-3-11-26(19(14)27)13-22(20(28)24-21(29)25-22)15-7-9-17(10-8-15)30-18-6-2-5-16(23)12-18/h2-12H,13H2,1H3,(H2,24,25,28,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



KAKEN PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)

More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM400728
PNG
(US10000476, Compound I-87)
Show SMILES Cc1cc(ccc1Oc1ccccc1)C1(Cn2cccc(C)c2=O)NC(=O)NC1=O
Show InChI InChI=1S/C23H21N3O4/c1-15-7-6-12-26(20(15)27)14-23(21(28)24-22(29)25-23)17-10-11-19(16(2)13-17)30-18-8-4-3-5-9-18/h3-13H,14H2,1-2H3,(H2,24,25,28,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



KAKEN PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)

More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM400736
PNG
(US10000476, Compound I-95 | US10000476, Compound I...)
Show SMILES Cc1cccn(CC2(NC(=O)NC2=O)c2cccc(c2)-c2ccccc2)c1=O
Show InChI InChI=1S/C22H19N3O3/c1-15-7-6-12-25(19(15)26)14-22(20(27)23-21(28)24-22)18-11-5-10-17(13-18)16-8-3-2-4-9-16/h2-13H,14H2,1H3,(H2,23,24,27,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



KAKEN PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)

More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM400752
PNG
(US10000476, Compound I-111)
Show SMILES Cc1cccn(CC2(NC(=O)NC2=O)c2ccc(Oc3ccc(F)cc3)c(F)c2)c1=O
Show InChI InChI=1S/C22H17F2N3O4/c1-13-3-2-10-27(19(13)28)12-22(20(29)25-21(30)26-22)14-4-9-18(17(24)11-14)31-16-7-5-15(23)6-8-16/h2-11H,12H2,1H3,(H2,25,26,29,30)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



KAKEN PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)

More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM400769
PNG
(US10000476, Compound I-128)
Show SMILES Cc1cc(cc(F)c1F)C1(Cn2cccc(C)c2=O)NC(=O)NC1=O
Show InChI InChI=1S/C17H15F2N3O3/c1-9-4-3-5-22(14(9)23)8-17(15(24)20-16(25)21-17)11-6-10(2)13(19)12(18)7-11/h3-7H,8H2,1-2H3,(H2,20,21,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



KAKEN PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)

More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM400723
PNG
(US10000476, Compound I-130 | US10000476, Compound ...)
Show SMILES Cc1cccn(CC2(NC(=O)NC2=O)c2ccc(Oc3ccc(Cl)cc3)cc2)c1=O
Show InChI InChI=1S/C22H18ClN3O4/c1-14-3-2-12-26(19(14)27)13-22(20(28)24-21(29)25-22)15-4-8-17(9-5-15)30-18-10-6-16(23)7-11-18/h2-12H,13H2,1H3,(H2,24,25,28,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



KAKEN PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)

More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM400399
PNG
(US10000476, Compound I-2)
Show SMILES COc1ccc(cc1)C1(Cn2cccc(C)c2=O)NC(=O)NC1=O
Show InChI InChI=1S/C17H17N3O4/c1-11-4-3-9-20(14(11)21)10-17(15(22)18-16(23)19-17)12-5-7-13(24-2)8-6-12/h3-9H,10H2,1-2H3,(H2,18,19,22,23)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



KAKEN PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)

More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM400645
PNG
(US10000476, Compound I-4 | US10000476, Compound I-...)
Show SMILES COc1cccc(c1)C1(Cn2cccc(C)c2=O)NC(=O)NC1=O
Show InChI InChI=1S/C17H17N3O4/c1-11-5-4-8-20(14(11)21)10-17(15(22)18-16(23)19-17)12-6-3-7-13(9-12)24-2/h3-9H,10H2,1-2H3,(H2,18,19,22,23)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



KAKEN PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)

More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM400648
PNG
(US10000476, Compound I-7)
Show SMILES Cc1cccn(CC2(NC(=O)NC2=O)c2ccccn2)c1=O
Show InChI InChI=1S/C15H14N4O3/c1-10-5-4-8-19(12(10)20)9-15(11-6-2-3-7-16-11)13(21)17-14(22)18-15/h2-8H,9H2,1H3,(H2,17,18,21,22)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



KAKEN PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)

More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM400653
PNG
(US10000476, Compound I-12)
Show SMILES COc1cc(ccc1F)C1(Cn2cccc(C)c2=O)NC(=O)NC1=O
Show InChI InChI=1S/C17H16FN3O4/c1-10-4-3-7-21(14(10)22)9-17(15(23)19-16(24)20-17)11-5-6-12(18)13(8-11)25-2/h3-8H,9H2,1-2H3,(H2,19,20,23,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



KAKEN PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)

More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM400659
PNG
(US10000476, Compound I-18)
Show SMILES COc1ccc(c(OC)c1)C1(Cn2cccc(C)c2=O)NC(=O)NC1=O
Show InChI InChI=1S/C18H19N3O5/c1-11-5-4-8-21(15(11)22)10-18(16(23)19-17(24)20-18)13-7-6-12(25-2)9-14(13)26-3/h4-9H,10H2,1-3H3,(H2,19,20,23,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



KAKEN PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)

More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM400660
PNG
(US10000476, Compound I-19)
Show SMILES Cc1cccn(CC2(NC(=O)NC2=O)c2cccc(c2)C(F)(F)F)c1=O
Show InChI InChI=1S/C17H14F3N3O3/c1-10-4-3-7-23(13(10)24)9-16(14(25)21-15(26)22-16)11-5-2-6-12(8-11)17(18,19)20/h2-8H,9H2,1H3,(H2,21,22,25,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



KAKEN PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)

More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM400670
PNG
(US10000476, Compound I-29)
Show SMILES Cc1cccn(CC2(NC(=O)NC2=O)c2cc(F)c(F)cc2F)c1=O
Show InChI InChI=1S/C16H12F3N3O3/c1-8-3-2-4-22(13(8)23)7-16(14(24)20-15(25)21-16)9-5-11(18)12(19)6-10(9)17/h2-6H,7H2,1H3,(H2,20,21,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



KAKEN PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)

More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM400683
PNG
(US10000476, Compound I-42)
Show SMILES Cc1cccn(CC2(NC(=O)NC2=O)c2ccc(cc2)-c2nn[nH]n2)c1=O
Show InChI InChI=1/C17H15N7O3/c1-10-3-2-8-24(14(10)25)9-17(15(26)18-16(27)19-17)12-6-4-11(5-7-12)13-20-22-23-21-13/h2-8H,9H2,1H3,(H2,18,19,26,27)(H,20,21,22,23)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



KAKEN PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)

More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM400689
PNG
(US10000476, Compound I-48)
Show SMILES Fc1ccc(cc1)C1(Cn2cccc(F)c2=O)NC(=O)NC1=O
Show InChI InChI=1S/C15H11F2N3O3/c16-10-5-3-9(4-6-10)15(13(22)18-14(23)19-15)8-20-7-1-2-11(17)12(20)21/h1-7H,8H2,(H2,18,19,22,23)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



KAKEN PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)

More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM400699
PNG
(US10000476, Compound I-58 | US10000476, Compound I...)
Show SMILES Cc1cccn(CC2(NC(=O)NC2=O)c2cccc(OCc3ccccc3)c2)c1=O
Show InChI InChI=1S/C23H21N3O4/c1-16-7-6-12-26(20(16)27)15-23(21(28)24-22(29)25-23)18-10-5-11-19(13-18)30-14-17-8-3-2-4-9-17/h2-13H,14-15H2,1H3,(H2,24,25,28,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



KAKEN PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)

More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM400712
PNG
(US10000476, Compound I-71)
Show SMILES CN(C)CC#Cc1ccccc1C1(Cn2cccc(C)c2=O)NC(=O)NC1=O
Show InChI InChI=1S/C21H22N4O3/c1-15-8-6-13-25(18(15)26)14-21(19(27)22-20(28)23-21)17-11-5-4-9-16(17)10-7-12-24(2)3/h4-6,8-9,11,13H,12,14H2,1-3H3,(H2,22,23,27,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



KAKEN PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)

More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM400721
PNG
(US10000476, Compound I-80)
Show SMILES Cc1cccc(Oc2ccc(cc2)C2(Cn3cccc(C)c3=O)NC(=O)NC2=O)c1
Show InChI InChI=1S/C23H21N3O4/c1-15-5-3-7-19(13-15)30-18-10-8-17(9-11-18)23(21(28)24-22(29)25-23)14-26-12-4-6-16(2)20(26)27/h3-13H,14H2,1-2H3,(H2,24,25,28,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



KAKEN PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)

More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM400733
PNG
(US10000476, Compound I-92)
Show SMILES Cc1cccn(CC2(NC(=O)NC2=O)c2ccc(cc2)-c2ccccn2)c1=O
Show InChI InChI=1S/C21H18N4O3/c1-14-5-4-12-25(18(14)26)13-21(19(27)23-20(28)24-21)16-9-7-15(8-10-16)17-6-2-3-11-22-17/h2-12H,13H2,1H3,(H2,23,24,27,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



KAKEN PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)

More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM400743
PNG
(US10000476, Compound I-102)
Show SMILES Cc1cccn(CC2(NC(=O)NC2=O)c2ccc(Sc3ccccc3)cc2)c1=O
Show InChI InChI=1S/C22H19N3O3S/c1-15-6-5-13-25(19(15)26)14-22(20(27)23-21(28)24-22)16-9-11-18(12-10-16)29-17-7-3-2-4-8-17/h2-13H,14H2,1H3,(H2,23,24,27,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



KAKEN PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)

More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM400744
PNG
(US10000476, Compound I-103)
Show SMILES Cc1cccn(CC2(NC(=O)NC2=O)c2ccc(Sc3ccccc3)c(F)c2)c1=O
Show InChI InChI=1S/C22H18FN3O3S/c1-14-6-5-11-26(19(14)27)13-22(20(28)24-21(29)25-22)15-9-10-18(17(23)12-15)30-16-7-3-2-4-8-16/h2-12H,13H2,1H3,(H2,24,25,28,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



KAKEN PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)

More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM400749
PNG
(US10000476, Compound I-108)
Show SMILES CC(=C)c1ccc(cc1)C1(Cn2cccc(C)c2=O)NC(=O)NC1=O
Show InChI InChI=1S/C19H19N3O3/c1-12(2)14-6-8-15(9-7-14)19(17(24)20-18(25)21-19)11-22-10-4-5-13(3)16(22)23/h4-10H,1,11H2,2-3H3,(H2,20,21,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



KAKEN PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)

More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM400758
PNG
(US10000476, Compound I-117)
Show SMILES CC(C)c1ccc(cc1)C1(Cn2cccc(C)c2=O)NC(=O)NC1=O
Show InChI InChI=1S/C19H21N3O3/c1-12(2)14-6-8-15(9-7-14)19(17(24)20-18(25)21-19)11-22-10-4-5-13(3)16(22)23/h4-10,12H,11H2,1-3H3,(H2,20,21,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



KAKEN PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)

More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM400764
PNG
(US10000476, Compound I-123)
Show SMILES Cc1cccn(CC2(NC(=O)NC2=O)c2ccc(Oc3ccccc3)c(Cl)c2)c1=O
Show InChI InChI=1S/C22H18ClN3O4/c1-14-6-5-11-26(19(14)27)13-22(20(28)24-21(29)25-22)15-9-10-18(17(23)12-15)30-16-7-3-2-4-8-16/h2-12H,13H2,1H3,(H2,24,25,28,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



KAKEN PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)

More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM400772
PNG
(US10000476, Compound I-131)
Show SMILES Cc1cc(ccc1OC1CCCCC1)C1(Cn2cccc(C)c2=O)NC(=O)NC1=O
Show InChI InChI=1S/C23H27N3O4/c1-15-7-6-12-26(20(15)27)14-23(21(28)24-22(29)25-23)17-10-11-19(16(2)13-17)30-18-8-4-3-5-9-18/h6-7,10-13,18H,3-5,8-9,14H2,1-2H3,(H2,24,25,28,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



KAKEN PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)

More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM400774
PNG
(US10000476, Compound I-133)
Show SMILES COc1ccc(cc1)C1(Cn2cccc(F)c2=O)NC(=O)NC1=O
Show InChI InChI=1S/C16H14FN3O4/c1-24-11-6-4-10(5-7-11)16(14(22)18-15(23)19-16)9-20-8-2-3-12(17)13(20)21/h2-8H,9H2,1H3,(H2,18,19,22,23)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



KAKEN PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)

More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM400778
PNG
(US10000476, Compound I-138)
Show SMILES Clc1cccn(CC2(NC(=O)NC2=O)c2ccc(cc2)C#N)c1=O
Show InChI InChI=1S/C16H11ClN4O3/c17-12-2-1-7-21(13(12)22)9-16(14(23)19-15(24)20-16)11-5-3-10(8-18)4-6-11/h1-7H,9H2,(H2,19,20,23,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



KAKEN PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)

More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM400782
PNG
(US10000476, Compound I-141)
Show SMILES COc1ccc(cc1)C1(Cn2cccc(c2=O)C(F)(F)F)NC(=O)NC1=O
Show InChI InChI=1S/C17H14F3N3O4/c1-27-11-6-4-10(5-7-11)16(14(25)21-15(26)22-16)9-23-8-2-3-12(13(23)24)17(18,19)20/h2-8H,9H2,1H3,(H2,21,22,25,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



KAKEN PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)

More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM400796
PNG
(US10000476, Compound I-155)
Show SMILES Fc1ccc(cc1F)C1(Cn2ccccc2=O)NC(=O)NC1=O
Show InChI InChI=1S/C15H11F2N3O3/c16-10-5-4-9(7-11(10)17)15(13(22)18-14(23)19-15)8-20-6-2-1-3-12(20)21/h1-7H,8H2,(H2,18,19,22,23)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



KAKEN PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)

More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM400651
PNG
(US10000476, Compound I-10 | US10000476, Compound I...)
Show SMILES Cc1cccn(CC2(NC(=O)NC2=O)c2ccc(F)c(F)c2)c1=O
Show InChI InChI=1S/C16H13F2N3O3/c1-9-3-2-6-21(13(9)22)8-16(14(23)19-15(24)20-16)10-4-5-11(17)12(18)7-10/h2-7H,8H2,1H3,(H2,19,20,23,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



KAKEN PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)

More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM400671
PNG
(US10000476, Compound I-30)
Show SMILES Cc1cc(ccc1F)C1(Cn2cccc(C)c2=O)NC(=O)NC1=O
Show InChI InChI=1S/C17H16FN3O3/c1-10-4-3-7-21(14(10)22)9-17(15(23)19-16(24)20-17)12-5-6-13(18)11(2)8-12/h3-8H,9H2,1-2H3,(H2,19,20,23,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



KAKEN PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)

More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 229 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%