BindingDB logo
myBDB logout

Patent code US10000476

Compile Data Set for Download or QSAR

Found 229 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))
BDBM400231
PNG
(US10000476, Compound I-1 | US10000476, Compound I-...)
Show SMILES Cc1cccn(CC2(NC(=O)NC2=O)c2ccncc2)c1=O
Show InChI InChI=1S/C15H14N4O3/c1-10-3-2-8-19(12(10)20)9-15(11-4-6-16-7-5-11)13(21)17-14(22)18-15/h2-8H,9H2,1H3,(H2,17,18,21,22)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Kaken Pharmaceutical Co., Ltd

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)


BindingDB Entry DOI: 10.7270/Q2V69MXD
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))
BDBM400721
PNG
(US10000476, Compound I-80)
Show SMILES Cc1cccc(Oc2ccc(cc2)C2(Cn3cccc(C)c3=O)NC(=O)NC2=O)c1
Show InChI InChI=1S/C23H21N3O4/c1-15-5-3-7-19(13-15)30-18-10-8-17(9-11-18)23(21(28)24-22(29)25-23)14-26-12-4-6-16(2)20(26)27/h3-13H,14H2,1-2H3,(H2,24,25,28,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Kaken Pharmaceutical Co., Ltd

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)


BindingDB Entry DOI: 10.7270/Q2V69MXD
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))
BDBM400722
PNG
(US10000476, Compound I-81)
Show SMILES COc1ccc(Oc2ccc(cc2)C2(Cn3cccc(C)c3=O)NC(=O)NC2=O)cc1
Show InChI InChI=1S/C23H21N3O5/c1-15-4-3-13-26(20(15)27)14-23(21(28)24-22(29)25-23)16-5-7-18(8-6-16)31-19-11-9-17(30-2)10-12-19/h3-13H,14H2,1-2H3,(H2,24,25,28,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Kaken Pharmaceutical Co., Ltd

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)


BindingDB Entry DOI: 10.7270/Q2V69MXD
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))
BDBM400728
PNG
(US10000476, Compound I-87)
Show SMILES Cc1cc(ccc1Oc1ccccc1)C1(Cn2cccc(C)c2=O)NC(=O)NC1=O
Show InChI InChI=1S/C23H21N3O4/c1-15-7-6-12-26(20(15)27)14-23(21(28)24-22(29)25-23)17-10-11-19(16(2)13-17)30-18-8-4-3-5-9-18/h3-13H,14H2,1-2H3,(H2,24,25,28,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Kaken Pharmaceutical Co., Ltd

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)


BindingDB Entry DOI: 10.7270/Q2V69MXD
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))
BDBM400733
PNG
(US10000476, Compound I-92)
Show SMILES Cc1cccn(CC2(NC(=O)NC2=O)c2ccc(cc2)-c2ccccn2)c1=O
Show InChI InChI=1S/C21H18N4O3/c1-14-5-4-12-25(18(14)26)13-21(19(27)23-20(28)24-21)16-9-7-15(8-10-16)17-6-2-3-11-22-17/h2-12H,13H2,1H3,(H2,23,24,27,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Kaken Pharmaceutical Co., Ltd

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)


BindingDB Entry DOI: 10.7270/Q2V69MXD
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))
BDBM400739
PNG
(US10000476, Compound I-98)
Show SMILES Cc1cccn(CC2(NC(=O)NC2=O)c2cccc(Oc3ccc(F)c(F)c3)c2)c1=O
Show InChI InChI=1S/C22H17F2N3O4/c1-13-4-3-9-27(19(13)28)12-22(20(29)25-21(30)26-22)14-5-2-6-15(10-14)31-16-7-8-17(23)18(24)11-16/h2-11H,12H2,1H3,(H2,25,26,29,30)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Kaken Pharmaceutical Co., Ltd

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)


BindingDB Entry DOI: 10.7270/Q2V69MXD
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))
BDBM400741
PNG
(US10000476, Compound I-100)
Show SMILES Cc1cccn(CC2(NC(=O)NC2=O)c2cccc(Oc3cccc(c3)C(F)(F)F)c2)c1=O
Show InChI InChI=1S/C23H18F3N3O4/c1-14-5-4-10-29(19(14)30)13-22(20(31)27-21(32)28-22)15-6-2-8-17(11-15)33-18-9-3-7-16(12-18)23(24,25)26/h2-12H,13H2,1H3,(H2,27,28,31,32)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Kaken Pharmaceutical Co., Ltd

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)


BindingDB Entry DOI: 10.7270/Q2V69MXD
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))
BDBM400757
PNG
(US10000476, Compound I-116)
Show SMILES CCc1ccc(cc1)C1(Cn2cccc(C)c2=O)NC(=O)NC1=O
Show InChI InChI=1S/C18H19N3O3/c1-3-13-6-8-14(9-7-13)18(16(23)19-17(24)20-18)11-21-10-4-5-12(2)15(21)22/h4-10H,3,11H2,1-2H3,(H2,19,20,23,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Kaken Pharmaceutical Co., Ltd

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)


BindingDB Entry DOI: 10.7270/Q2V69MXD
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))
BDBM400765
PNG
(US10000476, Compound I-124)
Show SMILES Cc1cccn(CC2(NC(=O)NC2=O)c2ccc(OC3CCCC3)cc2)c1=O
Show InChI InChI=1S/C21H23N3O4/c1-14-5-4-12-24(18(14)25)13-21(19(26)22-20(27)23-21)15-8-10-17(11-9-15)28-16-6-2-3-7-16/h4-5,8-12,16H,2-3,6-7,13H2,1H3,(H2,22,23,26,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Kaken Pharmaceutical Co., Ltd

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)


BindingDB Entry DOI: 10.7270/Q2V69MXD
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))
BDBM400787
PNG
(US10000476, Compound I-146)
Show SMILES Fc1ccc(cc1F)C1(Cn2cccc(Cl)c2=O)NC(=O)NC1=O
Show InChI InChI=1S/C15H10ClF2N3O3/c16-9-2-1-5-21(12(9)22)7-15(13(23)19-14(24)20-15)8-3-4-10(17)11(18)6-8/h1-6H,7H2,(H2,19,20,23,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Kaken Pharmaceutical Co., Ltd

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)


BindingDB Entry DOI: 10.7270/Q2V69MXD
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))
BDBM400231
PNG
(US10000476, Compound I-1 | US10000476, Compound I-...)
Show SMILES Cc1cccn(CC2(NC(=O)NC2=O)c2ccncc2)c1=O
Show InChI InChI=1S/C15H14N4O3/c1-10-3-2-8-19(12(10)20)9-15(11-4-6-16-7-5-11)13(21)17-14(22)18-15/h2-8H,9H2,1H3,(H2,17,18,21,22)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Kaken Pharmaceutical Co., Ltd

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)


BindingDB Entry DOI: 10.7270/Q2V69MXD
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))
BDBM400652
PNG
(US10000476, Compound I-11)
Show SMILES Cc1cccn(CC2(NC(=O)NC2=O)c2ccc(Br)cc2)c1=O
Show InChI InChI=1S/C16H14BrN3O3/c1-10-3-2-8-20(13(10)21)9-16(14(22)18-15(23)19-16)11-4-6-12(17)7-5-11/h2-8H,9H2,1H3,(H2,18,19,22,23)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Kaken Pharmaceutical Co., Ltd

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)


BindingDB Entry DOI: 10.7270/Q2V69MXD
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))
BDBM400669
PNG
(US10000476, Compound I-28)
Show SMILES Cc1cccn(CC2(NC(=O)NC2=O)c2cccc(F)c2)c1=O
Show InChI InChI=1S/C16H14FN3O3/c1-10-4-3-7-20(13(10)21)9-16(14(22)18-15(23)19-16)11-5-2-6-12(17)8-11/h2-8H,9H2,1H3,(H2,18,19,22,23)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Kaken Pharmaceutical Co., Ltd

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)


BindingDB Entry DOI: 10.7270/Q2V69MXD
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))
BDBM400670
PNG
(US10000476, Compound I-29)
Show SMILES Cc1cccn(CC2(NC(=O)NC2=O)c2cc(F)c(F)cc2F)c1=O
Show InChI InChI=1S/C16H12F3N3O3/c1-8-3-2-4-22(13(8)23)7-16(14(24)20-15(25)21-16)9-5-11(18)12(19)6-10(9)17/h2-6H,7H2,1H3,(H2,20,21,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Kaken Pharmaceutical Co., Ltd

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)


BindingDB Entry DOI: 10.7270/Q2V69MXD
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))
BDBM400671
PNG
(US10000476, Compound I-30)
Show SMILES Cc1cc(ccc1F)C1(Cn2cccc(C)c2=O)NC(=O)NC1=O
Show InChI InChI=1S/C17H16FN3O3/c1-10-4-3-7-21(14(10)22)9-17(15(23)19-16(24)20-17)12-5-6-13(18)11(2)8-12/h3-8H,9H2,1-2H3,(H2,19,20,23,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Kaken Pharmaceutical Co., Ltd

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)


BindingDB Entry DOI: 10.7270/Q2V69MXD
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))
BDBM400686
PNG
(US10000476, Compound I-45)
Show SMILES CCCc1ccc(cc1)C1(Cn2cccc(C)c2=O)NC(=O)NC1=O
Show InChI InChI=1S/C19H21N3O3/c1-3-5-14-7-9-15(10-8-14)19(17(24)20-18(25)21-19)12-22-11-4-6-13(2)16(22)23/h4,6-11H,3,5,12H2,1-2H3,(H2,20,21,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Kaken Pharmaceutical Co., Ltd

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)


BindingDB Entry DOI: 10.7270/Q2V69MXD
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))
BDBM400691
PNG
(US10000476, Compound I-50)
Show SMILES Clc1cccn(CC2(NC(=O)NC2=O)c2ccccc2)c1=O
Show InChI InChI=1S/C15H12ClN3O3/c16-11-7-4-8-19(12(11)20)9-15(10-5-2-1-3-6-10)13(21)17-14(22)18-15/h1-8H,9H2,(H2,17,18,21,22)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Kaken Pharmaceutical Co., Ltd

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)


BindingDB Entry DOI: 10.7270/Q2V69MXD
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))
BDBM400703
PNG
(US10000476, Compound I-62)
Show SMILES Cc1cccn(CC2(NC(=O)NC2=O)c2cccc(c2)-c2cccnc2)c1=O
Show InChI InChI=1S/C21H18N4O3/c1-14-5-4-10-25(18(14)26)13-21(19(27)23-20(28)24-21)17-8-2-6-15(11-17)16-7-3-9-22-12-16/h2-12H,13H2,1H3,(H2,23,24,27,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Kaken Pharmaceutical Co., Ltd

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)


BindingDB Entry DOI: 10.7270/Q2V69MXD
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))
BDBM400715
PNG
(US10000476, Compound I-74)
Show SMILES COc1ccccc1-c1ccc(cc1)C1(Cn2cccc(C)c2=O)NC(=O)NC1=O
Show InChI InChI=1S/C23H21N3O4/c1-15-6-5-13-26(20(15)27)14-23(21(28)24-22(29)25-23)17-11-9-16(10-12-17)18-7-3-4-8-19(18)30-2/h3-13H,14H2,1-2H3,(H2,24,25,28,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Kaken Pharmaceutical Co., Ltd

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)


BindingDB Entry DOI: 10.7270/Q2V69MXD
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))
BDBM400719
PNG
(US10000476, Compound I-78)
Show SMILES Cc1cccn(CC2(NC(=O)NC2=O)c2ccc(OC(F)F)cc2)c1=O
Show InChI InChI=1S/C17H15F2N3O4/c1-10-3-2-8-22(13(10)23)9-17(14(24)20-16(25)21-17)11-4-6-12(7-5-11)26-15(18)19/h2-8,15H,9H2,1H3,(H2,20,21,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Kaken Pharmaceutical Co., Ltd

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)


BindingDB Entry DOI: 10.7270/Q2V69MXD
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))
BDBM400725
PNG
(US10000476, Compound I-84)
Show SMILES Cc1cccn(CC2(NC(=O)NC2=O)c2ccc(Oc3cccc(F)c3)cc2)c1=O
Show InChI InChI=1S/C22H18FN3O4/c1-14-4-3-11-26(19(14)27)13-22(20(28)24-21(29)25-22)15-7-9-17(10-8-15)30-18-6-2-5-16(23)12-18/h2-12H,13H2,1H3,(H2,24,25,28,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Kaken Pharmaceutical Co., Ltd

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)


BindingDB Entry DOI: 10.7270/Q2V69MXD
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))
BDBM400734
PNG
(US10000476, Compound I-93)
Show SMILES Cc1cccn(CC2(NC(=O)NC2=O)c2cccc(c2)-c2ccc(F)cn2)c1=O
Show InChI InChI=1S/C21H17FN4O3/c1-13-4-3-9-26(18(13)27)12-21(19(28)24-20(29)25-21)15-6-2-5-14(10-15)17-8-7-16(22)11-23-17/h2-11H,12H2,1H3,(H2,24,25,28,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Kaken Pharmaceutical Co., Ltd

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)


BindingDB Entry DOI: 10.7270/Q2V69MXD
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))
BDBM400735
PNG
(US10000476, Compound I-94)
Show SMILES Cc1cccn(CC2(NC(=O)NC2=O)c2cccc(c2)-c2ccccn2)c1=O
Show InChI InChI=1S/C21H18N4O3/c1-14-6-5-11-25(18(14)26)13-21(19(27)23-20(28)24-21)16-8-4-7-15(12-16)17-9-2-3-10-22-17/h2-12H,13H2,1H3,(H2,23,24,27,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Kaken Pharmaceutical Co., Ltd

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)


BindingDB Entry DOI: 10.7270/Q2V69MXD
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))
BDBM400736
PNG
(US10000476, Compound I-95 | US10000476, Compound I...)
Show SMILES Cc1cccn(CC2(NC(=O)NC2=O)c2cccc(c2)-c2ccccc2)c1=O
Show InChI InChI=1S/C22H19N3O3/c1-15-7-6-12-25(19(15)26)14-22(20(27)23-21(28)24-22)18-11-5-10-17(13-18)16-8-3-2-4-9-16/h2-13H,14H2,1H3,(H2,23,24,27,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Kaken Pharmaceutical Co., Ltd

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)


BindingDB Entry DOI: 10.7270/Q2V69MXD
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))
BDBM400748
PNG
(US10000476, Compound I-107)
Show SMILES Cc1cccn(CC2(NC(=O)NC2=O)c2ccc(CCc3ccccc3)cc2)c1=O
Show InChI InChI=1S/C24H23N3O3/c1-17-6-5-15-27(21(17)28)16-24(22(29)25-23(30)26-24)20-13-11-19(12-14-20)10-9-18-7-3-2-4-8-18/h2-8,11-15H,9-10,16H2,1H3,(H2,25,26,29,30)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Kaken Pharmaceutical Co., Ltd

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)


BindingDB Entry DOI: 10.7270/Q2V69MXD
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))
BDBM400764
PNG
(US10000476, Compound I-123)
Show SMILES Cc1cccn(CC2(NC(=O)NC2=O)c2ccc(Oc3ccccc3)c(Cl)c2)c1=O
Show InChI InChI=1S/C22H18ClN3O4/c1-14-6-5-11-26(19(14)27)13-22(20(28)24-21(29)25-22)15-9-10-18(17(23)12-15)30-16-7-3-2-4-8-16/h2-12H,13H2,1H3,(H2,24,25,28,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Kaken Pharmaceutical Co., Ltd

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)


BindingDB Entry DOI: 10.7270/Q2V69MXD
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))
BDBM400779
PNG
(US10000476, Compound I-137)
Show SMILES COc1ccc(cc1)C1(Cn2cccc(Cl)c2=O)NC(=O)NC1=O
Show InChI InChI=1S/C16H14ClN3O4/c1-24-11-6-4-10(5-7-11)16(14(22)18-15(23)19-16)9-20-8-2-3-12(17)13(20)21/h2-8H,9H2,1H3,(H2,18,19,22,23)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Kaken Pharmaceutical Co., Ltd

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)


BindingDB Entry DOI: 10.7270/Q2V69MXD
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))
BDBM400778
PNG
(US10000476, Compound I-138)
Show SMILES Clc1cccn(CC2(NC(=O)NC2=O)c2ccc(cc2)C#N)c1=O
Show InChI InChI=1S/C16H11ClN4O3/c17-12-2-1-7-21(13(12)22)9-16(14(23)19-15(24)20-16)11-5-3-10(8-18)4-6-11/h1-7H,9H2,(H2,19,20,23,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Kaken Pharmaceutical Co., Ltd

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)


BindingDB Entry DOI: 10.7270/Q2V69MXD
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))
BDBM400682
PNG
(US10000476, Compound I-41)
Show SMILES Cc1cccn(CC2(NC(=O)NC2=O)c2ccc(Cc3ccc(F)cc3)cc2)c1=O
Show InChI InChI=1S/C23H20FN3O3/c1-15-3-2-12-27(20(15)28)14-23(21(29)25-22(30)26-23)18-8-4-16(5-9-18)13-17-6-10-19(24)11-7-17/h2-12H,13-14H2,1H3,(H2,25,26,29,30)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Kaken Pharmaceutical Co., Ltd

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)


BindingDB Entry DOI: 10.7270/Q2V69MXD
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))
BDBM400684
PNG
(US10000476, Compound I-43)
Show SMILES C=Cc1ccc(cc1)C1(Cn2ccccc2=O)NC(=O)NC1=O
Show InChI InChI=1S/C17H15N3O3/c1-2-12-6-8-13(9-7-12)17(15(22)18-16(23)19-17)11-20-10-4-3-5-14(20)21/h2-10H,1,11H2,(H2,18,19,22,23)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Kaken Pharmaceutical Co., Ltd

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)


BindingDB Entry DOI: 10.7270/Q2V69MXD
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))
BDBM400692
PNG
(US10000476, Compound I-51)
Show SMILES Clc1cccn(CC2(NC(=O)NC2=O)c2cc3ccccc3o2)c1=O
Show InChI InChI=1S/C17H12ClN3O4/c18-11-5-3-7-21(14(11)22)9-17(15(23)19-16(24)20-17)13-8-10-4-1-2-6-12(10)25-13/h1-8H,9H2,(H2,19,20,23,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Kaken Pharmaceutical Co., Ltd

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)


BindingDB Entry DOI: 10.7270/Q2V69MXD
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))
BDBM400708
PNG
(US10000476, Compound I-67)
Show SMILES Cc1cccn(CC2(NC(=O)NC2=O)c2ccccc2OC(F)(F)F)c1=O
Show InChI InChI=1S/C17H14F3N3O4/c1-10-5-4-8-23(13(10)24)9-16(14(25)21-15(26)22-16)11-6-2-3-7-12(11)27-17(18,19)20/h2-8H,9H2,1H3,(H2,21,22,25,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Kaken Pharmaceutical Co., Ltd

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)


BindingDB Entry DOI: 10.7270/Q2V69MXD
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))
BDBM400716
PNG
(US10000476, Compound I-75)
Show SMILES Cc1cccn(CC2(NC(=O)NC2=O)c2ccc(cc2)-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C22H18FN3O3/c1-14-3-2-12-26(19(14)27)13-22(20(28)24-21(29)25-22)17-8-4-15(5-9-17)16-6-10-18(23)11-7-16/h2-12H,13H2,1H3,(H2,24,25,28,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Kaken Pharmaceutical Co., Ltd

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)


BindingDB Entry DOI: 10.7270/Q2V69MXD
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))
BDBM400720
PNG
(US10000476, Compound I-79)
Show SMILES Cc1cccn(CC2(NC(=O)NC2=O)c2ccc(OC(F)(F)F)cc2)c1=O
Show InChI InChI=1S/C17H14F3N3O4/c1-10-3-2-8-23(13(10)24)9-16(14(25)21-15(26)22-16)11-4-6-12(7-5-11)27-17(18,19)20/h2-8H,9H2,1H3,(H2,21,22,25,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Kaken Pharmaceutical Co., Ltd

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)


BindingDB Entry DOI: 10.7270/Q2V69MXD
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))
BDBM400732
PNG
(US10000476, Compound I-91)
Show SMILES COc1ccncc1-c1ccc(cc1)C1(Cn2cccc(C)c2=O)NC(=O)NC1=O
Show InChI InChI=1S/C22H20N4O4/c1-14-4-3-11-26(19(14)27)13-22(20(28)24-21(29)25-22)16-7-5-15(6-8-16)17-12-23-10-9-18(17)30-2/h3-12H,13H2,1-2H3,(H2,24,25,28,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Kaken Pharmaceutical Co., Ltd

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)


BindingDB Entry DOI: 10.7270/Q2V69MXD
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))
BDBM400740
PNG
(US10000476, Compound I-99)
Show SMILES Cc1cccn(CC2(NC(=O)NC2=O)c2cccc(Oc3cc(F)cc(F)c3)c2)c1=O
Show InChI InChI=1S/C22H17F2N3O4/c1-13-4-3-7-27(19(13)28)12-22(20(29)25-21(30)26-22)14-5-2-6-17(8-14)31-18-10-15(23)9-16(24)11-18/h2-11H,12H2,1H3,(H2,25,26,29,30)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Kaken Pharmaceutical Co., Ltd

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)


BindingDB Entry DOI: 10.7270/Q2V69MXD
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))
BDBM400745
PNG
(US10000476, Compound I-104)
Show SMILES Cc1cccn(CC2(NC(=O)NC2=O)c2ccc(Oc3ccccc3F)c(F)c2)c1=O
Show InChI InChI=1S/C22H17F2N3O4/c1-13-5-4-10-27(19(13)28)12-22(20(29)25-21(30)26-22)14-8-9-18(16(24)11-14)31-17-7-3-2-6-15(17)23/h2-11H,12H2,1H3,(H2,25,26,29,30)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Kaken Pharmaceutical Co., Ltd

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)


BindingDB Entry DOI: 10.7270/Q2V69MXD
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))
BDBM400746
PNG
(US10000476, Compound I-105)
Show SMILES Cc1cccn(CC2(NC(=O)NC2=O)c2ccc3OCCCOc3c2)c1=O
Show InChI InChI=1S/C19H19N3O5/c1-12-4-2-7-22(16(12)23)11-19(17(24)20-18(25)21-19)13-5-6-14-15(10-13)27-9-3-8-26-14/h2,4-7,10H,3,8-9,11H2,1H3,(H2,20,21,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Kaken Pharmaceutical Co., Ltd

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)


BindingDB Entry DOI: 10.7270/Q2V69MXD
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))
BDBM400747
PNG
(US10000476, Compound I-106)
Show SMILES Cc1cccn(CC2(NC(=O)NC2=O)c2ccc(cc2)C#Cc2ccccc2)c1=O
Show InChI InChI=1S/C24H19N3O3/c1-17-6-5-15-27(21(17)28)16-24(22(29)25-23(30)26-24)20-13-11-19(12-14-20)10-9-18-7-3-2-4-8-18/h2-8,11-15H,16H2,1H3,(H2,25,26,29,30)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Kaken Pharmaceutical Co., Ltd

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)


BindingDB Entry DOI: 10.7270/Q2V69MXD
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))
BDBM400767
PNG
(US10000476, Compound I-126)
Show SMILES Cc1cccn(CC2(NC(=O)NC2=O)c2ccc(F)c(Cl)c2)c1=O
Show InChI InChI=1S/C16H13ClFN3O3/c1-9-3-2-6-21(13(9)22)8-16(14(23)19-15(24)20-16)10-4-5-12(18)11(17)7-10/h2-7H,8H2,1H3,(H2,19,20,23,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Kaken Pharmaceutical Co., Ltd

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)


BindingDB Entry DOI: 10.7270/Q2V69MXD
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))
BDBM400769
PNG
(US10000476, Compound I-128)
Show SMILES Cc1cc(cc(F)c1F)C1(Cn2cccc(C)c2=O)NC(=O)NC1=O
Show InChI InChI=1S/C17H15F2N3O3/c1-9-4-3-5-22(14(9)23)8-17(15(24)20-16(25)21-17)11-6-10(2)13(19)12(18)7-11/h3-7H,8H2,1-2H3,(H2,20,21,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Kaken Pharmaceutical Co., Ltd

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)


BindingDB Entry DOI: 10.7270/Q2V69MXD
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))
BDBM400772
PNG
(US10000476, Compound I-131)
Show SMILES Cc1cc(ccc1OC1CCCCC1)C1(Cn2cccc(C)c2=O)NC(=O)NC1=O
Show InChI InChI=1S/C23H27N3O4/c1-15-7-6-12-26(20(15)27)14-23(21(28)24-22(29)25-23)17-10-11-19(16(2)13-17)30-18-8-4-3-5-9-18/h6-7,10-13,18H,3-5,8-9,14H2,1-2H3,(H2,24,25,28,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Kaken Pharmaceutical Co., Ltd

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)


BindingDB Entry DOI: 10.7270/Q2V69MXD
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))
BDBM400776
PNG
(US10000476, Compound I-135)
Show SMILES Fc1cccn(CC2(NC(=O)NC2=O)c2ccc3ccccc3c2)c1=O
Show InChI InChI=1S/C19H14FN3O3/c20-15-6-3-9-23(16(15)24)11-19(17(25)21-18(26)22-19)14-8-7-12-4-1-2-5-13(12)10-14/h1-10H,11H2,(H2,21,22,25,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Kaken Pharmaceutical Co., Ltd

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)


BindingDB Entry DOI: 10.7270/Q2V69MXD
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))
BDBM400786
PNG
(US10000476, Compound I-145)
Show SMILES Fc1ccc(cc1F)C1(Cn2cccc(F)c2=O)NC(=O)NC1=O
Show InChI InChI=1S/C15H10F3N3O3/c16-9-4-3-8(6-11(9)18)15(13(23)19-14(24)20-15)7-21-5-1-2-10(17)12(21)22/h1-6H,7H2,(H2,19,20,23,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Kaken Pharmaceutical Co., Ltd

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)


BindingDB Entry DOI: 10.7270/Q2V69MXD
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))
BDBM400795
PNG
(US10000476, Compound I-154)
Show SMILES Cc1cccn(CC2(NC(=O)NC2=O)c2cc(F)cc(F)c2)c1=O
Show InChI InChI=1S/C16H13F2N3O3/c1-9-3-2-4-21(13(9)22)8-16(14(23)19-15(24)20-16)10-5-11(17)7-12(18)6-10/h2-7H,8H2,1H3,(H2,19,20,23,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Kaken Pharmaceutical Co., Ltd

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)


BindingDB Entry DOI: 10.7270/Q2V69MXD
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))
BDBM400796
PNG
(US10000476, Compound I-155)
Show SMILES Fc1ccc(cc1F)C1(Cn2ccccc2=O)NC(=O)NC1=O
Show InChI InChI=1S/C15H11F2N3O3/c16-10-5-4-9(7-11(10)17)15(13(22)18-14(23)19-15)8-20-6-2-1-3-12(20)21/h1-7H,8H2,(H2,18,19,22,23)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Kaken Pharmaceutical Co., Ltd

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)


BindingDB Entry DOI: 10.7270/Q2V69MXD
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))
BDBM400399
PNG
(US10000476, Compound I-2)
Show SMILES COc1ccc(cc1)C1(Cn2cccc(C)c2=O)NC(=O)NC1=O
Show InChI InChI=1S/C17H17N3O4/c1-11-4-3-9-20(14(11)21)10-17(15(22)18-16(23)19-17)12-5-7-13(24-2)8-6-12/h3-9H,10H2,1-2H3,(H2,18,19,22,23)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Kaken Pharmaceutical Co., Ltd

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)


BindingDB Entry DOI: 10.7270/Q2V69MXD
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))
BDBM400646
PNG
(US10000476, Compound I-5)
Show SMILES Cc1cccn(CC2(NC(=O)NC2=O)c2ccsc2)c1=O
Show InChI InChI=1S/C14H13N3O3S/c1-9-3-2-5-17(11(9)18)8-14(10-4-6-21-7-10)12(19)15-13(20)16-14/h2-7H,8H2,1H3,(H2,15,16,19,20)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Kaken Pharmaceutical Co., Ltd

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)


BindingDB Entry DOI: 10.7270/Q2V69MXD
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))
BDBM400654
PNG
(US10000476, Compound I-13)
Show SMILES COCOc1ccc(cc1)C1(Cn2cccc(C)c2=O)NC(=O)NC1=O
Show InChI InChI=1S/C18H19N3O5/c1-12-4-3-9-21(15(12)22)10-18(16(23)19-17(24)20-18)13-5-7-14(8-6-13)26-11-25-2/h3-9H,10-11H2,1-2H3,(H2,19,20,23,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Kaken Pharmaceutical Co., Ltd

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)


BindingDB Entry DOI: 10.7270/Q2V69MXD
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))
BDBM400660
PNG
(US10000476, Compound I-19)
Show SMILES Cc1cccn(CC2(NC(=O)NC2=O)c2cccc(c2)C(F)(F)F)c1=O
Show InChI InChI=1S/C17H14F3N3O3/c1-10-4-3-7-23(13(10)24)9-16(14(25)21-15(26)22-16)11-5-2-6-12(8-11)17(18,19)20/h2-8H,9H2,1H3,(H2,21,22,25,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Kaken Pharmaceutical Co., Ltd

US Patent


Assay Description
The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...


US Patent US10000476 (2018)


BindingDB Entry DOI: 10.7270/Q2V69MXD
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 229 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%