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Patent code US10000507

Compile Data Set for Download or QSAR

Found 426 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM400840
PNG
(2-Amino-N-[5-(1,4-diazepan-1-yl)-1-methyl-1H-pyraz...)
Show SMILES Cn1ncc(NC(=O)c2c(N)sc3cccnc23)c1N1CCCNCC1
Show InChI InChI=1S/C17H21N7OS/c1-23-17(24-8-3-5-19-7-9-24)11(10-21-23)22-16(25)13-14-12(26-15(13)18)4-2-6-20-14/h2,4,6,10,19H,3,5,7-9,18H2,1H3,(H,22,25)
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Incyte Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10000507 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM400850
PNG
(2-Amino-N-{4-[(3S)-3-aminopiperidin-1-yl]pyridin-3...)
Show SMILES COc1ccnc2c(C(=O)Nc3cnccc3N3CCC[C@H](N)C3)c(N)sc12
Show InChI InChI=1S/C19H22N6O2S/c1-27-14-5-7-23-16-15(18(21)28-17(14)16)19(26)24-12-9-22-6-4-13(12)25-8-2-3-11(20)10-25/h4-7,9,11H,2-3,8,10,20-21H2,1H3,(H,24,26)/t11-/m0/s1
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Incyte Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10000507 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM400855
PNG
(2-Amino-N-{4-[(3S)-3-aminopiperidin-1-yl]pyridin-3...)
Show SMILES CCc1cnc2c(C(=O)Nc3cnccc3N3CCC[C@H](N)C3)c(N)sc2c1
Show InChI InChI=1S/C20H24N6OS/c1-2-12-8-16-18(24-9-12)17(19(22)28-16)20(27)25-14-10-23-6-5-15(14)26-7-3-4-13(21)11-26/h5-6,8-10,13H,2-4,7,11,21-22H2,1H3,(H,25,27)/t13-/m0/s1
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Incyte Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10000507 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM400857
PNG
(2-Amino-N-{4-[(3S)-3-aminopiperidin-1-yl]pyridin-3...)
Show SMILES N[C@H]1CCCN(C1)c1ccncc1NC(=O)c1c(N)sc2cc(cnc12)-c1ccccc1
Show InChI InChI=1S/C24H24N6OS/c25-17-7-4-10-30(14-17)19-8-9-27-13-18(19)29-24(31)21-22-20(32-23(21)26)11-16(12-28-22)15-5-2-1-3-6-15/h1-3,5-6,8-9,11-13,17H,4,7,10,14,25-26H2,(H,29,31)/t17-/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10000507 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM400857
PNG
(2-Amino-N-{4-[(3S)-3-aminopiperidin-1-yl]pyridin-3...)
Show SMILES N[C@H]1CCCN(C1)c1ccncc1NC(=O)c1c(N)sc2cc(cnc12)-c1ccccc1
Show InChI InChI=1S/C24H24N6OS/c25-17-7-4-10-30(14-17)19-8-9-27-13-18(19)29-24(31)21-22-20(32-23(21)26)11-16(12-28-22)15-5-2-1-3-6-15/h1-3,5-6,8-9,11-13,17H,4,7,10,14,25-26H2,(H,29,31)/t17-/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10000507 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM400861
PNG
(2-Amino-N-{4-[(3S)-3-aminopiperidin-1-yl]pyridin-3...)
Show SMILES Cc1noc(C)c1-c1cnc2c(C(=O)Nc3cnccc3N3CCC[C@H](N)C3)c(N)sc2c1
Show InChI InChI=1S/C23H25N7O2S/c1-12-19(13(2)32-29-12)14-8-18-21(27-9-14)20(22(25)33-18)23(31)28-16-10-26-6-5-17(16)30-7-3-4-15(24)11-30/h5-6,8-10,15H,3-4,7,11,24-25H2,1-2H3,(H,28,31)/t15-/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10000507 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM400867
PNG
(2-Amino-N-{4-[(3S)-3-aminopiperidin-1-yl]pyridin-3...)
Show SMILES COCc1cnc2c(C(=O)Nc3cnccc3N3CCC[C@H](N)C3)c(N)sc2c1
Show InChI InChI=1S/C20H24N6O2S/c1-28-11-12-7-16-18(24-8-12)17(19(22)29-16)20(27)25-14-9-23-5-4-15(14)26-6-2-3-13(21)10-26/h4-5,7-9,13H,2-3,6,10-11,21-22H2,1H3,(H,25,27)/t13-/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10000507 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM400877
PNG
(2-Amino-N-[5-(4-aminoazepan-1-yl)-1-methyl-1H-pyra...)
Show SMILES Cn1ncc(NC(=O)c2c(N)sc3ccc(nc23)-c2ccccc2)c1N1CCCC(N)CC1
Show InChI InChI=1S/C24H27N7OS/c1-30-24(31-12-5-8-16(25)11-13-31)18(14-27-30)29-23(32)20-21-19(33-22(20)26)10-9-17(28-21)15-6-3-2-4-7-15/h2-4,6-7,9-10,14,16H,5,8,11-13,25-26H2,1H3,(H,29,32)
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10000507 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM400878
PNG
(2-Amino-N-{4-[(3S)-3-aminopiperidin-1-yl]pyridin-3...)
Show SMILES N[C@H]1CCCN(C1)c1ccncc1NC(=O)c1c(N)oc2cccnc12
Show InChI InChI=1S/C18H20N6O2/c19-11-3-2-8-24(10-11)13-5-7-21-9-12(13)23-18(25)15-16-14(26-17(15)20)4-1-6-22-16/h1,4-7,9,11H,2-3,8,10,19-20H2,(H,23,25)/t11-/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10000507 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM400881
PNG
(2-amino-N-{4-[(3S)-3-aminopiperidin-1- yl]pyridin-...)
Show SMILES N[C@H]1CCCN(C1)c1ccncc1NC(=O)c1c(N)oc2cc(cnc12)C(F)(F)F
Show InChI InChI=1S/C19H19F3N6O2/c20-19(21,22)10-6-14-16(26-7-10)15(17(24)30-14)18(29)27-12-8-25-4-3-13(12)28-5-1-2-11(23)9-28/h3-4,6-8,11H,1-2,5,9,23-24H2,(H,27,29)/t11-/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10000507 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM400887
PNG
(2-amino-N-{4-[(3S)-3-aminopiperidin-1- yl]pyridin-...)
Show SMILES N[C@H]1CCCN(C1)c1ccncc1NC(=O)c1c(N)oc2cc(Br)cnc12
Show InChI InChI=1S/C18H19BrN6O2/c19-10-6-14-16(23-7-10)15(17(21)27-14)18(26)24-12-8-22-4-3-13(12)25-5-1-2-11(20)9-25/h3-4,6-8,11H,1-2,5,9,20-21H2,(H,24,26)/t11-/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10000507 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM400889
PNG
(2-amino-N-[5-(4-aminoazepan-1-yl)-1- methyl-1H-pyr...)
Show SMILES Cn1ncc(NC(=O)c2c(N)oc3cc(cnc23)C(F)(F)F)c1N1CCCC(N)CC1
Show InChI InChI=1S/C19H22F3N7O2/c1-28-18(29-5-2-3-11(23)4-6-29)12(9-26-28)27-17(30)14-15-13(31-16(14)24)7-10(8-25-15)19(20,21)22/h7-9,11H,2-6,23-24H2,1H3,(H,27,30)
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10000507 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM400893
PNG
(2-amino-N-{4-[(3S,5R)-3-amino-5- (trifluoromethyl)...)
Show SMILES N[C@H]1C[C@H](CN(C1)c1ccncc1NC(=O)c1c(N)oc2cccnc12)C(F)(F)F
Show InChI InChI=1S/C19H19F3N6O2/c20-19(21,22)10-6-11(23)9-28(8-10)13-3-5-25-7-12(13)27-18(29)15-16-14(30-17(15)24)2-1-4-26-16/h1-5,7,10-11H,6,8-9,23-24H2,(H,27,29)/t10-,11+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10000507 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM400894
PNG
(2-amino-N-{4-[(3S,5R)-3-amino-5- (trifluoromethyl)...)
Show SMILES N[C@H]1C[C@H](CN(C1)c1ccncc1NC(=O)c1c(N)oc2cc(cnc12)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C20H18F6N6O2/c21-19(22,23)9-4-14-16(30-5-9)15(17(28)34-14)18(33)31-12-6-29-2-1-13(12)32-7-10(20(24,25)26)3-11(27)8-32/h1-2,4-6,10-11H,3,7-8,27-28H2,(H,31,33)/t10-,11+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10000507 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM400900
PNG
(2-Amino-N-{4-[(3R,4R,5S)-3-amino-4-hydroxy-5-methy...)
Show SMILES CCCc1cnc2c(C(=O)Nc3cnccc3N3C[C@H](C)[C@@H](O)[C@H](N)C3)c(N)oc2c1
Show InChI InChI=1S/C22H28N6O3/c1-3-4-13-7-17-19(26-8-13)18(21(24)31-17)22(30)27-15-9-25-6-5-16(15)28-10-12(2)20(29)14(23)11-28/h5-9,12,14,20,29H,3-4,10-11,23-24H2,1-2H3,(H,27,30)/t12-,14+,20+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10000507 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM400902
PNG
(2-Amino-N-{4-[(3S,5R)-3-amino-5-(trifluoromethyl)p...)
Show SMILES CCCc1cnc2c(C(=O)Nc3cnccc3N3C[C@@H](N)C[C@H](C3)C(F)(F)F)c(N)oc2c1
Show InChI InChI=1S/C22H25F3N6O2/c1-2-3-12-6-17-19(29-8-12)18(20(27)33-17)21(32)30-15-9-28-5-4-16(15)31-10-13(22(23,24)25)7-14(26)11-31/h4-6,8-9,13-14H,2-3,7,10-11,26-27H2,1H3,(H,30,32)/t13-,14+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10000507 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM400902
PNG
(2-Amino-N-{4-[(3S,5R)-3-amino-5-(trifluoromethyl)p...)
Show SMILES CCCc1cnc2c(C(=O)Nc3cnccc3N3C[C@@H](N)C[C@H](C3)C(F)(F)F)c(N)oc2c1
Show InChI InChI=1S/C22H25F3N6O2/c1-2-3-12-6-17-19(29-8-12)18(20(27)33-17)21(32)30-15-9-28-5-4-16(15)31-10-13(22(23,24)25)7-14(26)11-31/h4-6,8-9,13-14H,2-3,7,10-11,26-27H2,1H3,(H,30,32)/t13-,14+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10000507 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM400907
PNG
(2-Amino-N-{4-[(3R,4R,5S)-3-amino-4-hydroxy-5-methy...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NC(=O)c1c(N)oc2cccnc12
Show InChI InChI=1S/C19H22N6O3/c1-10-8-25(9-11(20)17(10)26)13-4-6-22-7-12(13)24-19(27)15-16-14(28-18(15)21)3-2-5-23-16/h2-7,10-11,17,26H,8-9,20-21H2,1H3,(H,24,27)/t10-,11+,17+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10000507 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM400908
PNG
(2-Amino-N-{4-[(3R,4R,5S)-3-amino-4-hydroxy-5-methy...)
Show SMILES CC(C)c1cnc2c(C(=O)Nc3cnccc3N3C[C@H](C)[C@@H](O)[C@H](N)C3)c(N)oc2c1
Show InChI InChI=1S/C22H28N6O3/c1-11(2)13-6-17-19(26-7-13)18(21(24)31-17)22(30)27-15-8-25-5-4-16(15)28-9-12(3)20(29)14(23)10-28/h4-8,11-12,14,20,29H,9-10,23-24H2,1-3H3,(H,27,30)/t12-,14+,20+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10000507 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM400910
PNG
(2-Amino-N-{5-methyl-4-[(3R,4R,5S)-3-amino-4-hydrox...)
Show SMILES CCCc1cnc2c(C(=O)Nc3cncc(C)c3N3C[C@H](C)[C@@H](O)[C@H](N)C3)c(N)oc2c1
Show InChI InChI=1S/C23H30N6O3/c1-4-5-14-6-17-19(27-8-14)18(22(25)32-17)23(31)28-16-9-26-7-12(2)20(16)29-10-13(3)21(30)15(24)11-29/h6-9,13,15,21,30H,4-5,10-11,24-25H2,1-3H3,(H,28,31)/t13-,15+,21+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10000507 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM400912
PNG
(2-Amino-N-{5-methyl-4-[(3R,4R,5S)-3-amino-4-hydrox...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1c(C)cncc1NC(=O)c1c(N)oc2cc(cnc12)C(F)(F)F
Show InChI InChI=1S/C21H23F3N6O3/c1-9-4-27-6-13(17(9)30-7-10(2)18(31)12(25)8-30)29-20(32)15-16-14(33-19(15)26)3-11(5-28-16)21(22,23)24/h3-6,10,12,18,31H,7-8,25-26H2,1-2H3,(H,29,32)/t10-,12+,18+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10000507 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM400913
PNG
(2-Amino-N-{4-[(3R,4R)-3-amino-4-fluoro-piperidin-1...)
Show SMILES CCCc1cnc2c(C(=O)Nc3cnccc3N3CC[C@@H](F)[C@H](N)C3)c(N)oc2c1
Show InChI InChI=1S/C21H25FN6O2/c1-2-3-12-8-17-19(26-9-12)18(20(24)30-17)21(29)27-15-10-25-6-4-16(15)28-7-5-13(22)14(23)11-28/h4,6,8-10,13-14H,2-3,5,7,11,23-24H2,1H3,(H,27,29)/t13-,14-/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10000507 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM400917
PNG
(2-Amino-N-(4-((1R,3R,4R,5S)-3-amino-4-hydroxy-4,5-...)
Show SMILES CCCc1cnc2c(C(=O)Nc3cnccc3[C@@H]3C[C@H](C)[C@@](C)(O)[C@H](N)C3)c(N)oc2c1
Show InChI InChI=1S/C24H31N5O3/c1-4-5-14-9-18-21(28-11-14)20(22(26)32-18)23(30)29-17-12-27-7-6-16(17)15-8-13(2)24(3,31)19(25)10-15/h6-7,9,11-13,15,19,31H,4-5,8,10,25-26H2,1-3H3,(H,29,30)/t13-,15+,19+,24+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10000507 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM400920
PNG
(US10000507, Example 87(Diastereoisomer-1))
Show SMILES N[C@@H]1CN(C[C@@H]([C@H]1O)C(F)(F)F)c1ccncc1NC(=O)c1c(N)oc2cccnc12
Show InChI InChI=1S/C19H19F3N6O3/c20-19(21,22)9-7-28(8-10(23)16(9)29)12-3-5-25-6-11(12)27-18(30)14-15-13(31-17(14)24)2-1-4-26-15/h1-6,9-10,16,29H,7-8,23-24H2,(H,27,30)/t9-,10+,16+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10000507 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM400935
PNG
(2-Amino-N-{4-[(3S,5R)-3-amino-5-(trifluoromethyl)p...)
Show SMILES N[C@H]1C[C@H](CN(C1)c1ccncc1NC(=O)c1c(N)oc2cc(CN3CC(O)C3)cnc12)C(F)(F)F
Show InChI InChI=1S/C23H26F3N7O3/c24-23(25,26)13-4-14(27)9-33(8-13)17-1-2-29-6-16(17)31-22(35)19-20-18(36-21(19)28)3-12(5-30-20)7-32-10-15(34)11-32/h1-3,5-6,13-15,34H,4,7-11,27-28H2,(H,31,35)/t13-,14+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10000507 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM400938
PNG
(2-Amino-N-{4-[(3S,5R)-3-amino-5-(trifluoromethyl)p...)
Show SMILES CCOC1CCN(Cc2cnc3c(C(=O)Nc4cnccc4N4C[C@@H](N)C[C@H](C4)C(F)(F)F)c(N)oc3c2)C1
Show InChI InChI=1S/C26H32F3N7O3/c1-2-38-18-4-6-35(14-18)11-15-7-21-23(33-9-15)22(24(31)39-21)25(37)34-19-10-32-5-3-20(19)36-12-16(26(27,28)29)8-17(30)13-36/h3,5,7,9-10,16-18H,2,4,6,8,11-14,30-31H2,1H3,(H,34,37)/t16-,17+,18?/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10000507 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM400941
PNG
(2-Amino-N-{4-[(3S,5R)-3-amino-5-(trifluoromethyl)p...)
Show SMILES COC1CCN(Cc2cnc3c(C(=O)Nc4cnccc4N4C[C@@H](N)C[C@H](C4)C(F)(F)F)c(N)oc3c2)CC1
Show InChI InChI=1S/C26H32F3N7O3/c1-38-18-3-6-35(7-4-18)12-15-8-21-23(33-10-15)22(24(31)39-21)25(37)34-19-11-32-5-2-20(19)36-13-16(26(27,28)29)9-17(30)14-36/h2,5,8,10-11,16-18H,3-4,6-7,9,12-14,30-31H2,1H3,(H,34,37)/t16-,17+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10000507 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM400945
PNG
(2-Amino-N-{4-[(3S,5R)-3-amino-5-(trifluoromethyl)p...)
Show SMILES N[C@H]1C[C@H](CN(C1)c1ccncc1NC(=O)c1c(N)oc2cc(cnc12)-c1cncnc1)C(F)(F)F
Show InChI InChI=1S/C23H21F3N8O2/c24-23(25,26)14-4-15(27)10-34(9-14)17-1-2-29-8-16(17)33-22(35)19-20-18(36-21(19)28)3-12(7-32-20)13-5-30-11-31-6-13/h1-3,5-8,11,14-15H,4,9-10,27-28H2,(H,33,35)/t14-,15+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10000507 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM400945
PNG
(2-Amino-N-{4-[(3S,5R)-3-amino-5-(trifluoromethyl)p...)
Show SMILES N[C@H]1C[C@H](CN(C1)c1ccncc1NC(=O)c1c(N)oc2cc(cnc12)-c1cncnc1)C(F)(F)F
Show InChI InChI=1S/C23H21F3N8O2/c24-23(25,26)14-4-15(27)10-34(9-14)17-1-2-29-8-16(17)33-22(35)19-20-18(36-21(19)28)3-12(7-32-20)13-5-30-11-31-6-13/h1-3,5-8,11,14-15H,4,9-10,27-28H2,(H,33,35)/t14-,15+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10000507 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM400947
PNG
(2-Amino-N-{4-[(3S,5R)-3-amino-5-(trifluoromethyl)p...)
Show SMILES N[C@H]1C[C@H](CN(C1)c1ccncc1NC(=O)c1c(N)oc2cc(cnc12)C1CC1)C(F)(F)F
Show InChI InChI=1S/C22H23F3N6O2/c23-22(24,25)13-6-14(26)10-31(9-13)16-3-4-28-8-15(16)30-21(32)18-19-17(33-20(18)27)5-12(7-29-19)11-1-2-11/h3-5,7-8,11,13-14H,1-2,6,9-10,26-27H2,(H,30,32)/t13-,14+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10000507 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM400958
PNG
(2-Amino-N-{4-[(3R,4R,5S)-3-amino-4-hydroxy-5-methy...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NC(=O)c1c(N)oc2cc(cnc12)C1CCC1
Show InChI InChI=1S/C23H28N6O3/c1-12-10-29(11-15(24)21(12)30)17-5-6-26-9-16(17)28-23(31)19-20-18(32-22(19)25)7-14(8-27-20)13-3-2-4-13/h5-9,12-13,15,21,30H,2-4,10-11,24-25H2,1H3,(H,28,31)/t12-,15+,21+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10000507 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM400962
PNG
(2-Amino-N-(4-((3R,4R,5S)-3-amino-5-cyclopropyl-4-h...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NC(=O)c1c(N)oc2cc(cnc12)C1CC1
Show InChI InChI=1S/C22H26N6O3/c1-11-9-28(10-14(23)20(11)29)16-4-5-25-8-15(16)27-22(30)18-19-17(31-21(18)24)6-13(7-26-19)12-2-3-12/h4-8,11-12,14,20,29H,2-3,9-10,23-24H2,1H3,(H,27,30)/t11-,14+,20+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10000507 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM400973
PNG
(2-Amino-N-(4-((3R,4R,5S)-3-amino-4-hydroxy-5-methy...)
Show SMILES CC(C)c1cnc2c(C(=O)Nc3cnccc3N3C[C@H](C)[C@@H](O)[C@H](N)C3)c(N)sc2c1
Show InChI InChI=1S/C22H28N6O2S/c1-11(2)13-6-17-19(26-7-13)18(21(24)31-17)22(30)27-15-8-25-5-4-16(15)28-9-12(3)20(29)14(23)10-28/h4-8,11-12,14,20,29H,9-10,23-24H2,1-3H3,(H,27,30)/t12-,14+,20+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10000507 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM400974
PNG
(2-Amino-N-(4-((3R,4R,5S)-3-amino-4-hydroxy-5-methy...)
Show SMILES CCCc1cnc2c(C(=O)Nc3cnccc3N3C[C@H](C)[C@@H](O)[C@H](N)C3)c(N)sc2c1
Show InChI InChI=1S/C22H28N6O2S/c1-3-4-13-7-17-19(26-8-13)18(21(24)31-17)22(30)27-15-9-25-6-5-16(15)28-10-12(2)20(29)14(23)11-28/h5-9,12,14,20,29H,3-4,10-11,23-24H2,1-2H3,(H,27,30)/t12-,14+,20+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10000507 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM400853
PNG
(2-Amino-N-[5-(4-aminoazepan-1-yl)-1-methyl-1H-pyra...)
Show SMILES CC(C)Oc1ccnc2c(C(=O)Nc3cnn(C)c3N3CCCC(N)CC3)c(N)sc12
Show InChI InChI=1S/C21H29N7O2S/c1-12(2)30-15-6-8-24-17-16(19(23)31-18(15)17)20(29)26-14-11-25-27(3)21(14)28-9-4-5-13(22)7-10-28/h6,8,11-13H,4-5,7,9-10,22-23H2,1-3H3,(H,26,29)
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10000507 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM400858
PNG
(2-Amino-N-[5-(4-aminoazepan-1-yl)-1-methyl-1H-pyra...)
Show SMILES Cn1ncc(NC(=O)c2c(N)sc3cc(cnc23)-c2ccccc2)c1N1CCCC(N)CC1
Show InChI InChI=1S/C24H27N7OS/c1-30-24(31-10-5-8-17(25)9-11-31)18(14-28-30)29-23(32)20-21-19(33-22(20)26)12-16(13-27-21)15-6-3-2-4-7-15/h2-4,6-7,12-14,17H,5,8-11,25-26H2,1H3,(H,29,32)
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10000507 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM400863
PNG
(2-Amino-N-[5-(4-aminoazepan-1-yl)-1-methyl-1H-pyra...)
Show SMILES Cn1ncc(NC(=O)c2c(N)sc3cc(cnc23)-c2nccs2)c1N1CCCC(N)CC1
Show InChI InChI=1S/C21H24N8OS2/c1-28-21(29-6-2-3-13(22)4-7-29)14(11-26-28)27-19(30)16-17-15(32-18(16)23)9-12(10-25-17)20-24-5-8-31-20/h5,8-11,13H,2-4,6-7,22-23H2,1H3,(H,27,30)
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10000507 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM400865
PNG
(2-Amino-N-[5-(4-aminoazepan-1-yl)-1-methyl-1H-pyra...)
Show SMILES CN1CC(C1)c1cnc2c(C(=O)Nc3cnn(C)c3N3CCCC(N)CC3)c(N)sc2c1
Show InChI InChI=1S/C22H30N8OS/c1-28-11-14(12-28)13-8-17-19(25-9-13)18(20(24)32-17)21(31)27-16-10-26-29(2)22(16)30-6-3-4-15(23)5-7-30/h8-10,14-15H,3-7,11-12,23-24H2,1-2H3,(H,27,31)
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10000507 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM400868
PNG
(2-Amino-N-{4-[(3S)-3-aminopiperidin-1-yl]pyridin-3...)
Show SMILES N[C@H]1CCCN(C1)c1ccncc1NC(=O)c1c(N)sc2cc(cnc12)C1CCOCC1
Show InChI InChI=1S/C23H28N6O2S/c24-16-2-1-7-29(13-16)18-3-6-26-12-17(18)28-23(30)20-21-19(32-22(20)25)10-15(11-27-21)14-4-8-31-9-5-14/h3,6,10-12,14,16H,1-2,4-5,7-9,13,24-25H2,(H,28,30)/t16-/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10000507 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM400871
PNG
(2-Amino-N-{4-[(3S)-3-aminopiperidin-1-yl]pyridin-3...)
Show SMILES N[C@H]1CCCN(C1)c1ccncc1NC(=O)c1c(N)sc2c(ccnc12)C(F)(F)F
Show InChI InChI=1S/C19H19F3N6OS/c20-19(21,22)11-3-6-26-15-14(17(24)30-16(11)15)18(29)27-12-8-25-5-4-13(12)28-7-1-2-10(23)9-28/h3-6,8,10H,1-2,7,9,23-24H2,(H,27,29)/t10-/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10000507 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM400884
PNG
(2-amino-N-{4-[(3S)-3-aminopiperidin-1- yl]pyridin-...)
Show SMILES CCCc1cnc2c(C(=O)Nc3cnccc3N3CCC[C@H](N)C3)c(N)oc2c1
Show InChI InChI=1S/C21H26N6O2/c1-2-4-13-9-17-19(25-10-13)18(20(23)29-17)21(28)26-15-11-24-7-6-16(15)27-8-3-5-14(22)12-27/h6-7,9-11,14H,2-5,8,12,22-23H2,1H3,(H,26,28)/t14-/m0/s1
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Incyte Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10000507 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM400895
PNG
(2-amino-N-{4-[(3S,5R)-3-amino-5- (trifluoromethyl)...)
Show SMILES N[C@H]1C[C@H](CN(C1)c1ccncc1NC(=O)c1c(N)oc2cc(Cl)cnc12)C(F)(F)F
Show InChI InChI=1S/C19H18ClF3N6O2/c20-10-4-14-16(27-5-10)15(17(25)31-14)18(30)28-12-6-26-2-1-13(12)29-7-9(19(21,22)23)3-11(24)8-29/h1-2,4-6,9,11H,3,7-8,24-25H2,(H,28,30)/t9-,11+/m1/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10000507 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM400900
PNG
(2-Amino-N-{4-[(3R,4R,5S)-3-amino-4-hydroxy-5-methy...)
Show SMILES CCCc1cnc2c(C(=O)Nc3cnccc3N3C[C@H](C)[C@@H](O)[C@H](N)C3)c(N)oc2c1
Show InChI InChI=1S/C22H28N6O3/c1-3-4-13-7-17-19(26-8-13)18(21(24)31-17)22(30)27-15-9-25-6-5-16(15)28-10-12(2)20(29)14(23)11-28/h5-9,12,14,20,29H,3-4,10-11,23-24H2,1-2H3,(H,27,30)/t12-,14+,20+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10000507 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM400900
PNG
(2-Amino-N-{4-[(3R,4R,5S)-3-amino-4-hydroxy-5-methy...)
Show SMILES CCCc1cnc2c(C(=O)Nc3cnccc3N3C[C@H](C)[C@@H](O)[C@H](N)C3)c(N)oc2c1
Show InChI InChI=1S/C22H28N6O3/c1-3-4-13-7-17-19(26-8-13)18(21(24)31-17)22(30)27-15-9-25-6-5-16(15)28-10-12(2)20(29)14(23)11-28/h5-9,12,14,20,29H,3-4,10-11,23-24H2,1-2H3,(H,27,30)/t12-,14+,20+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10000507 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM400902
PNG
(2-Amino-N-{4-[(3S,5R)-3-amino-5-(trifluoromethyl)p...)
Show SMILES CCCc1cnc2c(C(=O)Nc3cnccc3N3C[C@@H](N)C[C@H](C3)C(F)(F)F)c(N)oc2c1
Show InChI InChI=1S/C22H25F3N6O2/c1-2-3-12-6-17-19(29-8-12)18(20(27)33-17)21(32)30-15-9-28-5-4-16(15)31-10-13(22(23,24)25)7-14(26)11-31/h4-6,8-9,13-14H,2-3,7,10-11,26-27H2,1H3,(H,30,32)/t13-,14+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10000507 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM400903
PNG
(2-Amino-N-{4-[(3S,5R)-3-amino-5-methyl-piperidin-1...)
Show SMILES CCCc1cnc2c(C(=O)Nc3cnccc3N3C[C@H](C)C[C@H](N)C3)c(N)oc2c1
Show InChI InChI=1S/C22H28N6O2/c1-3-4-14-8-18-20(26-9-14)19(21(24)30-18)22(29)27-16-10-25-6-5-17(16)28-11-13(2)7-15(23)12-28/h5-6,8-10,13,15H,3-4,7,11-12,23-24H2,1-2H3,(H,27,29)/t13-,15+/m1/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10000507 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM400904
PNG
(2-Amino-N-{4-[(3S,5R)-3-amino-5-methyl-piperidin-1...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NC(=O)c1c(N)oc2cc(F)cnc12
Show InChI InChI=1S/C19H21FN6O2/c1-10-4-12(21)9-26(8-10)14-2-3-23-7-13(14)25-19(27)16-17-15(28-18(16)22)5-11(20)6-24-17/h2-3,5-7,10,12H,4,8-9,21-22H2,1H3,(H,25,27)/t10-,12+/m1/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10000507 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM400910
PNG
(2-Amino-N-{5-methyl-4-[(3R,4R,5S)-3-amino-4-hydrox...)
Show SMILES CCCc1cnc2c(C(=O)Nc3cncc(C)c3N3C[C@H](C)[C@@H](O)[C@H](N)C3)c(N)oc2c1
Show InChI InChI=1S/C23H30N6O3/c1-4-5-14-6-17-19(27-8-14)18(22(25)32-17)23(31)28-16-9-26-7-12(2)20(16)29-10-13(3)21(30)15(24)11-29/h6-9,13,15,21,30H,4-5,10-11,24-25H2,1-3H3,(H,28,31)/t13-,15+,21+/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10000507 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM400912
PNG
(2-Amino-N-{5-methyl-4-[(3R,4R,5S)-3-amino-4-hydrox...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1c(C)cncc1NC(=O)c1c(N)oc2cc(cnc12)C(F)(F)F
Show InChI InChI=1S/C21H23F3N6O3/c1-9-4-27-6-13(17(9)30-7-10(2)18(31)12(25)8-30)29-20(32)15-16-14(33-19(15)26)3-11(5-28-16)21(22,23)24/h3-6,10,12,18,31H,7-8,25-26H2,1-2H3,(H,29,32)/t10-,12+,18+/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10000507 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM400918
PNG
(2-Amino-N-{4-[(3R,4R,5S)-3-amino-4-hydroxy-4,5-dim...)
Show SMILES CCCc1cnc2c(C(=O)Nc3cnccc3N3C[C@H](C)[C@@](C)(O)[C@H](N)C3)c(N)oc2c1
Show InChI InChI=1S/C23H30N6O3/c1-4-5-14-8-17-20(27-9-14)19(21(25)32-17)22(30)28-15-10-26-7-6-16(15)29-11-13(2)23(3,31)18(24)12-29/h6-10,13,18,31H,4-5,11-12,24-25H2,1-3H3,(H,28,30)/t13-,18+,23+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10000507 (2018)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%