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Patent code US10004755

Compile Data Set for Download or QSAR
Found 149 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM350865
PNG
(UNC1667A | US10004755, Compound UNC1667A | US97956...)
Show SMILES CCCCNc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N1CCN(C)CC1
Show InChI InChI=1/C27H38N6O3S/c1-3-4-13-28-27-29-18-24-25(19-33(26(24)30-27)21-7-9-22(34)10-8-21)20-5-11-23(12-6-20)37(35,36)32-16-14-31(2)15-17-32/h5-6,11-12,18-19,21-22,34H,3-4,7-10,13-17H2,1-2H3,(H,28,29,30)/t21-,22-
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n/an/a 0.420n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM350848
PNG
(UNC2078A | US10004755, Compound UNC2078A | US97956...)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N1CCCCC1
Show InChI InChI=1/C27H37N5O3S/c1-2-3-15-28-27-29-18-24-25(19-32(26(24)30-27)21-9-11-22(33)12-10-21)20-7-13-23(14-8-20)36(34,35)31-16-5-4-6-17-31/h7-8,13-14,18-19,21-22,33H,2-6,9-12,15-17H2,1H3,(H,28,29,30)/t21?,22-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM50055498
PNG
(CHEMBL3326004 | US10004755, Compound UNC1669A | US...)
Show SMILES CCCCNc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(c(F)c1)S(=O)(=O)N1CCN(C)CC1
Show InChI InChI=1/C27H37FN6O3S/c1-3-4-11-29-27-30-17-22-23(18-34(26(22)31-27)20-6-8-21(35)9-7-20)19-5-10-25(24(28)16-19)38(36,37)33-14-12-32(2)13-15-33/h5,10,16-18,20-21,35H,3-4,6-9,11-15H2,1-2H3,(H,29,30,31)/t20-,21-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM350844
PNG
(UNC1972A | US10004755, Compound UNC1972A | US97956...)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](N)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N1CCOCC1
Show InChI InChI=1/C26H36N6O3S/c1-2-3-12-28-26-29-17-23-24(18-32(25(23)30-26)21-8-6-20(27)7-9-21)19-4-10-22(11-5-19)36(33,34)31-13-15-35-16-14-31/h4-5,10-11,17-18,20-21H,2-3,6-9,12-16,27H2,1H3,(H,28,29,30)/t20-,21?
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM350843
PNG
(UNC1971A | US10004755, Compound UNC1971A | US97956...)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](N)CC3)c2n1)-c1ccc(c(F)c1)S(=O)(=O)N1CCOCC1
Show InChI InChI=1/C26H35FN6O3S/c1-2-3-10-29-26-30-16-21-22(17-33(25(21)31-26)20-7-5-19(28)6-8-20)18-4-9-24(23(27)15-18)37(34,35)32-11-13-36-14-12-32/h4,9,15-17,19-20H,2-3,5-8,10-14,28H2,1H3,(H,29,30,31)/t19-,20?
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM350852
PNG
(UNC2124A | US10004755, Compound UNC2124A | US97956...)
Show SMILES N[C@H]1CCC(CC1)n1cc(-c2ccc(F)cc2)c2cnc(NCCCCO)nc12
Show InChI InChI=1/C22H28FN5O/c23-16-5-3-15(4-6-16)20-14-28(18-9-7-17(24)8-10-18)21-19(20)13-26-22(27-21)25-11-1-2-12-29/h3-6,13-14,17-18,29H,1-2,7-12,24H2,(H,25,26,27)/t17-,18?
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM350851
PNG
(UNC2123A | US10004755, Compound UNC2123A | US97956...)
Show SMILES N[C@H]1CCC(CC1)n1cc(-c2ccc(F)cc2)c2cnc(NCCC3CC3)nc12
Show InChI InChI=1/C23H28FN5/c24-17-5-3-16(4-6-17)21-14-29(19-9-7-18(25)8-10-19)22-20(21)13-27-23(28-22)26-12-11-15-1-2-15/h3-6,13-15,18-19H,1-2,7-12,25H2,(H,26,27,28)/t18-,19?
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM350850
PNG
(UNC2095A | US10004755, Compound UNC2095A | US97956...)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N1CCC(F)(F)CC1
Show InChI InChI=1/C27H35F2N5O3S/c1-2-3-14-30-26-31-17-23-24(18-34(25(23)32-26)20-6-8-21(35)9-7-20)19-4-10-22(11-5-19)38(36,37)33-15-12-27(28,29)13-16-33/h4-5,10-11,17-18,20-21,35H,2-3,6-9,12-16H2,1H3,(H,30,31,32)/t20?,21-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM401001
PNG
(US10004755, Compound UNC2396A)
Show SMILES CN1CCN(Cc2ccc(cc2)-c2cn(C3CC[C@H](O)CC3)c3nc(NCCCCO)ncc23)CC1
Show InChI InChI=1S/C28H40N6O2/c1-32-13-15-33(16-14-32)19-21-4-6-22(7-5-21)26-20-34(23-8-10-24(36)11-9-23)27-25(26)18-30-28(31-27)29-12-2-3-17-35/h4-7,18,20,23-24,35-36H,2-3,8-17,19H2,1H3,(H,29,30,31)/t23?,24-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM350861
PNG
(UNC2371A | US10004755, Compound UNC2371A | US97956...)
Show SMILES CN1CCN(Cc2ccc(cc2)-c2cn(C3CC[C@H](O)CC3)c3nc(NCCC4CC4)ncc23)CC1
Show InChI InChI=1/C29H40N6O/c1-33-14-16-34(17-15-33)19-22-4-6-23(7-5-22)27-20-35(24-8-10-25(36)11-9-24)28-26(27)18-31-29(32-28)30-13-12-21-2-3-21/h4-7,18,20-21,24-25,36H,2-3,8-17,19H2,1H3,(H,30,31,32)/t24?,25-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM350855
PNG
(UNC2143A | US10004755, Compound UNC2143A | US97956...)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(CN2CCNCC2)cc1
Show InChI InChI=1/C27H38N6O/c1-2-3-12-29-27-30-17-24-25(19-33(26(24)31-27)22-8-10-23(34)11-9-22)21-6-4-20(5-7-21)18-32-15-13-28-14-16-32/h4-7,17,19,22-23,28,34H,2-3,8-16,18H2,1H3,(H,29,30,31)/t22?,23-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM350851
PNG
(UNC2123A | US10004755, Compound UNC2123A | US97956...)
Show SMILES N[C@H]1CCC(CC1)n1cc(-c2ccc(F)cc2)c2cnc(NCCC3CC3)nc12
Show InChI InChI=1/C23H28FN5/c24-17-5-3-16(4-6-17)21-14-29(19-9-7-18(25)8-10-19)22-20(21)13-27-23(28-22)26-12-11-15-1-2-15/h3-6,13-15,18-19H,1-2,7-12,25H2,(H,26,27,28)/t18-,19?
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM350842
PNG
(UNC1970A | US10004755, Compound UNC1970A | US97956...)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](N)CC3)c2n1)-c1ccc(F)cc1
Show InChI InChI=1/C22H28FN5/c1-2-3-12-25-22-26-13-19-20(15-4-6-16(23)7-5-15)14-28(21(19)27-22)18-10-8-17(24)9-11-18/h4-7,13-14,17-18H,2-3,8-12,24H2,1H3,(H,25,26,27)/t17-,18?
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM350868
PNG
(UNC1670A | US10004755, Compound UNC1670A | US97956...)
Show SMILES CCCCNc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(c(F)c1)S(=O)(=O)N1CCOCC1
Show InChI InChI=1/C26H34FN5O4S/c1-2-3-10-28-26-29-16-21-22(17-32(25(21)30-26)19-5-7-20(33)8-6-19)18-4-9-24(23(27)15-18)37(34,35)31-11-13-36-14-12-31/h4,9,15-17,19-20,33H,2-3,5-8,10-14H2,1H3,(H,28,29,30)/t19-,20-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM350845
PNG
(UNC2025A | US10004755, Compound UNC2025A | US97956...)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(CN2CCN(C)CC2)cc1
Show InChI InChI=1/C28H40N6O/c1-3-4-13-29-28-30-18-25-26(20-34(27(25)31-28)23-9-11-24(35)12-10-23)22-7-5-21(6-8-22)19-33-16-14-32(2)15-17-33/h5-8,18,20,23-24,35H,3-4,9-17,19H2,1-2H3,(H,29,30,31)/t23?,24-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM350861
PNG
(UNC2371A | US10004755, Compound UNC2371A | US97956...)
Show SMILES CN1CCN(Cc2ccc(cc2)-c2cn(C3CC[C@H](O)CC3)c3nc(NCCC4CC4)ncc23)CC1
Show InChI InChI=1/C29H40N6O/c1-33-14-16-34(17-15-33)19-22-4-6-23(7-5-22)27-20-35(24-8-10-25(36)11-9-24)28-26(27)18-31-29(32-28)30-13-12-21-2-3-21/h4-7,18,20-21,24-25,36H,2-3,8-17,19H2,1H3,(H,30,31,32)/t24?,25-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50055498
PNG
(CHEMBL3326004 | US10004755, Compound UNC1669A | US...)
Show SMILES CCCCNc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(c(F)c1)S(=O)(=O)N1CCN(C)CC1
Show InChI InChI=1/C27H37FN6O3S/c1-3-4-11-29-27-30-17-22-23(18-34(26(22)31-27)20-6-8-21(35)9-7-20)19-5-10-25(24(28)16-19)38(36,37)33-14-12-32(2)13-15-33/h5,10,16-18,20-21,35H,3-4,6-9,11-15H2,1-2H3,(H,29,30,31)/t20-,21-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM350847
PNG
(UNC2087A | US10004755, Compound UNC2087A | US97956...)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)C1CCCC1
Show InChI InChI=1/C27H36N4O3S/c1-2-3-16-28-27-29-17-24-25(18-31(26(24)30-27)20-10-12-21(32)13-11-20)19-8-14-23(15-9-19)35(33,34)22-6-4-5-7-22/h8-9,14-15,17-18,20-22,32H,2-7,10-13,16H2,1H3,(H,28,29,30)/t20?,21-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM350850
PNG
(UNC2095A | US10004755, Compound UNC2095A | US97956...)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N1CCC(F)(F)CC1
Show InChI InChI=1/C27H35F2N5O3S/c1-2-3-14-30-26-31-17-23-24(18-34(25(23)32-26)20-6-8-21(35)9-7-20)19-4-10-22(11-5-19)38(36,37)33-15-12-27(28,29)13-16-33/h4-5,10-11,17-18,20-21,35H,2-3,6-9,12-16H2,1H3,(H,30,31,32)/t20?,21-
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n/an/a 1.30n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM350845
PNG
(UNC2025A | US10004755, Compound UNC2025A | US97956...)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(CN2CCN(C)CC2)cc1
Show InChI InChI=1/C28H40N6O/c1-3-4-13-29-28-30-18-25-26(20-34(27(25)31-28)23-9-11-24(35)12-10-23)22-7-5-21(6-8-22)19-33-16-14-32(2)15-17-33/h5-8,18,20,23-24,35H,3-4,9-17,19H2,1-2H3,(H,29,30,31)/t23?,24-
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n/an/a 1.30n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM350856
PNG
(UNC2146A | US10004755, Compound UNC2146A | US97956...)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N1CC(F)(F)C1
Show InChI InChI=1/C25H31F2N5O3S/c1-2-3-12-28-24-29-13-21-22(14-32(23(21)30-24)18-6-8-19(33)9-7-18)17-4-10-20(11-5-17)36(34,35)31-15-25(26,27)16-31/h4-5,10-11,13-14,18-19,33H,2-3,6-9,12,15-16H2,1H3,(H,28,29,30)/t18?,19-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM350864
PNG
(UNC1666A | US10004755, Compound UNC1666A | US97956...)
Show SMILES CCCCNc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N1CCOCC1
Show InChI InChI=1/C26H35N5O4S/c1-2-3-12-27-26-28-17-23-24(18-31(25(23)29-26)20-6-8-21(32)9-7-20)19-4-10-22(11-5-19)36(33,34)30-13-15-35-16-14-30/h4-5,10-11,17-18,20-21,32H,2-3,6-9,12-16H2,1H3,(H,27,28,29)/t20-,21-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM401017
PNG
(US10004755, Compound UNC4291A)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)N1CCN(C)CC1
Show InChI InChI=1S/C27H38N6O/c1-3-4-13-28-27-29-18-24-25(19-33(26(24)30-27)22-9-11-23(34)12-10-22)20-5-7-21(8-6-20)32-16-14-31(2)15-17-32/h5-8,18-19,22-23,34H,3-4,9-17H2,1-2H3,(H,28,29,30)/t22?,23-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM350858
PNG
(UNC2367A | US10004755, Compound UNC2367A | US97956...)
Show SMILES CN1CCN(CC1)S(=O)(=O)c1ccc(-c2cn(C3CC[C@H](O)CC3)c3nc(NCCC4CC4)ncc23)c(F)c1
Show InChI InChI=1/C28H37FN6O3S/c1-33-12-14-34(15-13-33)39(37,38)22-8-9-23(26(29)16-22)25-18-35(20-4-6-21(36)7-5-20)27-24(25)17-31-28(32-27)30-11-10-19-2-3-19/h8-9,16-21,36H,2-7,10-15H2,1H3,(H,30,31,32)/t20?,21-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM350853
PNG
(UNC2125A | US10004755, Compound UNC2125A | US97956...)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](N)CC3)c2n1)-c1ccc(F)c(F)c1
Show InChI InChI=1/C22H27F2N5/c1-2-3-10-26-22-27-12-17-18(14-4-9-19(23)20(24)11-14)13-29(21(17)28-22)16-7-5-15(25)6-8-16/h4,9,11-13,15-16H,2-3,5-8,10,25H2,1H3,(H,26,27,28)/t15-,16?
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM401000
PNG
(US10004755, Compound UNC2395A)
Show SMILES OCCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(CN2CCOCC2)cc1
Show InChI InChI=1S/C27H37N5O3/c33-14-2-1-11-28-27-29-17-24-25(19-32(26(24)30-27)22-7-9-23(34)10-8-22)21-5-3-20(4-6-21)18-31-12-15-35-16-13-31/h3-6,17,19,22-23,33-34H,1-2,7-16,18H2,(H,28,29,30)/t22?,23-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM350852
PNG
(UNC2124A | US10004755, Compound UNC2124A | US97956...)
Show SMILES N[C@H]1CCC(CC1)n1cc(-c2ccc(F)cc2)c2cnc(NCCCCO)nc12
Show InChI InChI=1/C22H28FN5O/c23-16-5-3-15(4-6-16)20-14-28(18-9-7-17(24)8-10-18)21-19(20)13-26-22(27-21)25-11-1-2-12-29/h3-6,13-14,17-18,29H,1-2,7-12,24H2,(H,25,26,27)/t17-,18?
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM350868
PNG
(UNC1670A | US10004755, Compound UNC1670A | US97956...)
Show SMILES CCCCNc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(c(F)c1)S(=O)(=O)N1CCOCC1
Show InChI InChI=1/C26H34FN5O4S/c1-2-3-10-28-26-29-16-21-22(17-32(25(21)30-26)19-5-7-20(33)8-6-19)18-4-9-24(23(27)15-18)37(34,35)31-11-13-36-14-12-31/h4,9,15-17,19-20,33H,2-3,5-8,10-14H2,1H3,(H,28,29,30)/t19-,20-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM350857
PNG
(UNC2253A | US10004755, Compound UNC2253A | US97956...)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)C1(CC1)N1CCOCC1
Show InChI InChI=1/C29H39N5O2/c1-2-3-14-30-28-31-19-25-26(20-34(27(25)32-28)23-8-10-24(35)11-9-23)21-4-6-22(7-5-21)29(12-13-29)33-15-17-36-18-16-33/h4-7,19-20,23-24,35H,2-3,8-18H2,1H3,(H,30,31,32)/t23?,24-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM350846
PNG
(UNC2026A | US10004755, Compound UNC2026A | US97956...)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)C1CCOCC1
Show InChI InChI=1/C27H36N4O4S/c1-2-3-14-28-27-29-17-24-25(18-31(26(24)30-27)20-6-8-21(32)9-7-20)19-4-10-22(11-5-19)36(33,34)23-12-15-35-16-13-23/h4-5,10-11,17-18,20-21,23,32H,2-3,6-9,12-16H2,1H3,(H,28,29,30)/t20?,21-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM350857
PNG
(UNC2253A | US10004755, Compound UNC2253A | US97956...)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)C1(CC1)N1CCOCC1
Show InChI InChI=1/C29H39N5O2/c1-2-3-14-30-28-31-19-25-26(20-34(27(25)32-28)23-8-10-24(35)11-9-23)21-4-6-22(7-5-21)29(12-13-29)33-15-17-36-18-16-33/h4-7,19-20,23-24,35H,2-3,8-18H2,1H3,(H,30,31,32)/t23?,24-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM350860
PNG
(UNC2370A | US10004755, Compound UNC2370A | US97956...)
Show SMILES O[C@H]1CCC(CC1)n1cc(-c2ccc(CN3CCOCC3)cc2)c2cnc(NCCC3CC3)nc12
Show InChI InChI=1/C28H37N5O2/c34-24-9-7-23(8-10-24)33-19-26(22-5-3-21(4-6-22)18-32-13-15-35-16-14-32)25-17-30-28(31-27(25)33)29-12-11-20-1-2-20/h3-6,17,19-20,23-24,34H,1-2,7-16,18H2,(H,29,30,31)/t23?,24-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM350842
PNG
(UNC1970A | US10004755, Compound UNC1970A | US97956...)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](N)CC3)c2n1)-c1ccc(F)cc1
Show InChI InChI=1/C22H28FN5/c1-2-3-12-25-22-26-13-19-20(15-4-6-16(23)7-5-15)14-28(21(19)27-22)18-10-8-17(24)9-11-18/h4-7,13-14,17-18H,2-3,8-12,24H2,1H3,(H,25,26,27)/t17-,18?
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM401013
PNG
(US10004755, Compound UNC4319A)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(NC2CCCNCC2)cc1
Show InChI InChI=1S/C28H40N6O/c1-2-3-16-30-28-31-18-25-26(19-34(27(25)33-28)23-10-12-24(35)13-11-23)20-6-8-22(9-7-20)32-21-5-4-15-29-17-14-21/h6-9,18-19,21,23-24,29,32,35H,2-5,10-17H2,1H3,(H,30,31,33)/t21?,23?,24-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM350854
PNG
(UNC2142A | US10004755, Compound UNC2142A | US97956...)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(CN2CCOCC2)cc1
Show InChI InChI=1/C27H37N5O2/c1-2-3-12-28-27-29-17-24-25(19-32(26(24)30-27)22-8-10-23(33)11-9-22)21-6-4-20(5-7-21)18-31-13-15-34-16-14-31/h4-7,17,19,22-23,33H,2-3,8-16,18H2,1H3,(H,28,29,30)/t22?,23-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM401001
PNG
(US10004755, Compound UNC2396A)
Show SMILES CN1CCN(Cc2ccc(cc2)-c2cn(C3CC[C@H](O)CC3)c3nc(NCCCCO)ncc23)CC1
Show InChI InChI=1S/C28H40N6O2/c1-32-13-15-33(16-14-32)19-21-4-6-22(7-5-21)26-20-34(23-8-10-24(36)11-9-23)27-25(26)18-30-28(31-27)29-12-2-3-17-35/h4-7,18,20,23-24,35-36H,2-3,8-17,19H2,1H3,(H,29,30,31)/t23?,24-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM350864
PNG
(UNC1666A | US10004755, Compound UNC1666A | US97956...)
Show SMILES CCCCNc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N1CCOCC1
Show InChI InChI=1/C26H35N5O4S/c1-2-3-12-27-26-28-17-23-24(18-31(25(23)29-26)20-6-8-21(32)9-7-20)19-4-10-22(11-5-19)36(33,34)30-13-15-35-16-14-30/h4-5,10-11,17-18,20-21,32H,2-3,6-9,12-16H2,1H3,(H,27,28,29)/t20-,21-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM350860
PNG
(UNC2370A | US10004755, Compound UNC2370A | US97956...)
Show SMILES O[C@H]1CCC(CC1)n1cc(-c2ccc(CN3CCOCC3)cc2)c2cnc(NCCC3CC3)nc12
Show InChI InChI=1/C28H37N5O2/c34-24-9-7-23(8-10-24)33-19-26(22-5-3-21(4-6-22)18-32-13-15-35-16-14-32)25-17-30-28(31-27(25)33)29-12-11-20-1-2-20/h3-6,17,19-20,23-24,34H,1-2,7-16,18H2,(H,29,30,31)/t23?,24-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM350859
PNG
(UNC2368A | US10004755, Compound UNC2368A | US97956...)
Show SMILES O[C@H]1CCC(CC1)n1cc(-c2ccc(cc2F)S(=O)(=O)N2CCOCC2)c2cnc(NCCC3CC3)nc12
Show InChI InChI=1/C27H34FN5O4S/c28-25-15-21(38(35,36)32-11-13-37-14-12-32)7-8-22(25)24-17-33(19-3-5-20(34)6-4-19)26-23(24)16-30-27(31-26)29-10-9-18-1-2-18/h7-8,15-20,34H,1-6,9-14H2,(H,29,30,31)/t19?,20-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM350866
PNG
(UNC1668A | US10004755, Compound UNC1668A | US97956...)
Show SMILES CCCCNc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(N2CCOCC2)c(F)c1
Show InChI InChI=1/C26H34FN5O2/c1-2-3-10-28-26-29-16-21-22(17-32(25(21)30-26)19-5-7-20(33)8-6-19)18-4-9-24(23(27)15-18)31-11-13-34-14-12-31/h4,9,15-17,19-20,33H,2-3,5-8,10-14H2,1H3,(H,28,29,30)/t19-,20-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM401013
PNG
(US10004755, Compound UNC4319A)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(NC2CCCNCC2)cc1
Show InChI InChI=1S/C28H40N6O/c1-2-3-16-30-28-31-18-25-26(19-34(27(25)33-28)23-10-12-24(35)13-11-23)20-6-8-22(9-7-20)32-21-5-4-15-29-17-14-21/h6-9,18-19,21,23-24,29,32,35H,2-5,10-17H2,1H3,(H,30,31,33)/t21?,23?,24-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM350854
PNG
(UNC2142A | US10004755, Compound UNC2142A | US97956...)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(CN2CCOCC2)cc1
Show InChI InChI=1/C27H37N5O2/c1-2-3-12-28-27-29-17-24-25(19-32(26(24)30-27)22-8-10-23(33)11-9-22)21-6-4-20(5-7-21)18-31-13-15-34-16-14-31/h4-7,17,19,22-23,33H,2-3,8-16,18H2,1H3,(H,28,29,30)/t22?,23-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM350846
PNG
(UNC2026A | US10004755, Compound UNC2026A | US97956...)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)C1CCOCC1
Show InChI InChI=1/C27H36N4O4S/c1-2-3-14-28-27-29-17-24-25(18-31(26(24)30-27)20-6-8-21(32)9-7-20)19-4-10-22(11-5-19)36(33,34)23-12-15-35-16-13-23/h4-5,10-11,17-18,20-21,23,32H,2-3,6-9,12-16H2,1H3,(H,28,29,30)/t20?,21-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM401016
PNG
(US10004755, Compound UNC4218A)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(CN2CCCN(C)CC2)cc1
Show InChI InChI=1S/C29H42N6O/c1-3-4-14-30-29-31-19-26-27(21-35(28(26)32-29)24-10-12-25(36)13-11-24)23-8-6-22(7-9-23)20-34-16-5-15-33(2)17-18-34/h6-9,19,21,24-25,36H,3-5,10-18,20H2,1-2H3,(H,30,31,32)/t24?,25-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM350858
PNG
(UNC2367A | US10004755, Compound UNC2367A | US97956...)
Show SMILES CN1CCN(CC1)S(=O)(=O)c1ccc(-c2cn(C3CC[C@H](O)CC3)c3nc(NCCC4CC4)ncc23)c(F)c1
Show InChI InChI=1/C28H37FN6O3S/c1-33-12-14-34(15-13-33)39(37,38)22-8-9-23(26(29)16-22)25-18-35(20-4-6-21(36)7-5-20)27-24(25)17-31-28(32-27)30-11-10-19-2-3-19/h8-9,16-21,36H,2-7,10-15H2,1H3,(H,30,31,32)/t20?,21-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM350859
PNG
(UNC2368A | US10004755, Compound UNC2368A | US97956...)
Show SMILES O[C@H]1CCC(CC1)n1cc(-c2ccc(cc2F)S(=O)(=O)N2CCOCC2)c2cnc(NCCC3CC3)nc12
Show InChI InChI=1/C27H34FN5O4S/c28-25-15-21(38(35,36)32-11-13-37-14-12-32)7-8-22(25)24-17-33(19-3-5-20(34)6-4-19)26-23(24)16-30-27(31-26)29-10-9-18-1-2-18/h7-8,15-20,34H,1-6,9-14H2,(H,29,30,31)/t19?,20-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM401000
PNG
(US10004755, Compound UNC2395A)
Show SMILES OCCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(CN2CCOCC2)cc1
Show InChI InChI=1S/C27H37N5O3/c33-14-2-1-11-28-27-29-17-24-25(19-32(26(24)30-27)22-7-9-23(34)10-8-22)21-5-3-20(4-6-21)18-31-12-15-35-16-13-31/h3-6,17,19,22-23,33-34H,1-2,7-16,18H2,(H,28,29,30)/t22?,23-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM401016
PNG
(US10004755, Compound UNC4218A)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(CN2CCCN(C)CC2)cc1
Show InChI InChI=1S/C29H42N6O/c1-3-4-14-30-29-31-19-26-27(21-35(28(26)32-29)24-10-12-25(36)13-11-24)23-8-6-22(7-9-23)20-34-16-5-15-33(2)17-18-34/h6-9,19,21,24-25,36H,3-5,10-18,20H2,1-2H3,(H,30,31,32)/t24?,25-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM401017
PNG
(US10004755, Compound UNC4291A)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)N1CCN(C)CC1
Show InChI InChI=1S/C27H38N6O/c1-3-4-13-28-27-29-18-24-25(19-33(26(24)30-27)22-9-11-23(34)12-10-22)20-5-7-21(8-6-20)32-16-14-31(2)15-17-32/h5-8,18-19,22-23,34H,3-4,9-17H2,1-2H3,(H,28,29,30)/t22?,23-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM350849
PNG
(UNC2094A | US10004755, Compound UNC2094A | US97956...)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(F)c(F)c1
Show InChI InChI=1/C22H26F2N4O/c1-2-3-10-25-22-26-12-17-18(14-4-9-19(23)20(24)11-14)13-28(21(17)27-22)15-5-7-16(29)8-6-15/h4,9,11-13,15-16,29H,2-3,5-8,10H2,1H3,(H,25,26,27)/t15?,16-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM401010
PNG
(US10004755, Compound UNC4308A)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(NC2CCNCC2)cc1
Show InChI InChI=1S/C27H38N6O/c1-2-3-14-29-27-30-17-24-25(18-33(26(24)32-27)22-8-10-23(34)11-9-22)19-4-6-20(7-5-19)31-21-12-15-28-16-13-21/h4-7,17-18,21-23,28,31,34H,2-3,8-16H2,1H3,(H,29,30,32)/t22?,23-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM401012
PNG
(US10004755, Compound UNC4311A)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(NC2CCN(C)CC2)cc1
Show InChI InChI=1S/C28H40N6O/c1-3-4-15-29-28-30-18-25-26(19-34(27(25)32-28)23-9-11-24(35)12-10-23)20-5-7-21(8-6-20)31-22-13-16-33(2)17-14-22/h5-8,18-19,22-24,31,35H,3-4,9-17H2,1-2H3,(H,29,30,32)/t23?,24-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM401002
PNG
(US10004755, Compound UNC1651A)
Show SMILES CCCCNc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(c(F)c1)S(=O)(=O)N1CCN(CC(F)(F)F)CC1
Show InChI InChI=1S/C28H36F4N6O3S/c1-2-3-10-33-27-34-16-22-23(17-38(26(22)35-27)20-5-7-21(39)8-6-20)19-4-9-25(24(29)15-19)42(40,41)37-13-11-36(12-14-37)18-28(30,31)32/h4,9,15-17,20-21,39H,2-3,5-8,10-14,18H2,1H3,(H,33,34,35)/t20-,21-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM350844
PNG
(UNC1972A | US10004755, Compound UNC1972A | US97956...)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](N)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N1CCOCC1
Show InChI InChI=1/C26H36N6O3S/c1-2-3-12-28-26-29-17-23-24(18-32(25(23)30-26)21-8-6-20(27)7-9-21)19-4-10-22(11-5-19)36(33,34)31-13-15-35-16-14-31/h4-5,10-11,17-18,20-21H,2-3,6-9,12-16,27H2,1H3,(H,28,29,30)/t20-,21?
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM401011
PNG
(US10004755, Compound UNC4309A)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(NC2CCCCC2)cc1
Show InChI InChI=1S/C28H39N5O/c1-2-3-17-29-28-30-18-25-26(19-33(27(25)32-28)23-13-15-24(34)16-14-23)20-9-11-22(12-10-20)31-21-7-5-4-6-8-21/h9-12,18-19,21,23-24,31,34H,2-8,13-17H2,1H3,(H,29,30,32)/t23?,24-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM401012
PNG
(US10004755, Compound UNC4311A)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(NC2CCN(C)CC2)cc1
Show InChI InChI=1S/C28H40N6O/c1-3-4-15-29-28-30-18-25-26(19-34(27(25)32-28)23-9-11-24(35)12-10-23)20-5-7-21(8-6-20)31-22-13-16-33(2)17-14-22/h5-8,18-19,22-24,31,35H,3-4,9-17H2,1-2H3,(H,29,30,32)/t23?,24-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM401003
PNG
(US10004755, Compound UNC1652A)
Show SMILES CCCCNc1ncc2c(cn([C@@H]3CC[C@H](O)CC3)c2n1)-c1ccc(c(F)c1)S(=O)(=O)N1CCN(CC(F)(F)F)CC1
Show InChI InChI=1S/C28H36F4N6O3S/c1-2-3-10-33-27-34-16-22-23(17-38(26(22)35-27)20-5-7-21(39)8-6-20)19-4-9-25(24(29)15-19)42(40,41)37-13-11-36(12-14-37)18-28(30,31)32/h4,9,15-17,20-21,39H,2-3,5-8,10-14,18H2,1H3,(H,33,34,35)/t20-,21+
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM401010
PNG
(US10004755, Compound UNC4308A)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(NC2CCNCC2)cc1
Show InChI InChI=1S/C27H38N6O/c1-2-3-14-29-27-30-17-24-25(18-33(26(24)32-27)22-8-10-23(34)11-9-22)19-4-6-20(7-5-19)31-21-12-15-28-16-13-21/h4-7,17-18,21-23,28,31,34H,2-3,8-16H2,1H3,(H,29,30,32)/t22?,23-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM401014
PNG
(US10004755, Compound UNC4320A)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(NC2CCCN(C)CC2)cc1
Show InChI InChI=1S/C29H42N6O/c1-3-4-16-30-29-31-19-26-27(20-35(28(26)33-29)24-11-13-25(36)14-12-24)21-7-9-23(10-8-21)32-22-6-5-17-34(2)18-15-22/h7-10,19-20,22,24-25,32,36H,3-6,11-18H2,1-2H3,(H,30,31,33)/t22?,24?,25-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM401002
PNG
(US10004755, Compound UNC1651A)
Show SMILES CCCCNc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(c(F)c1)S(=O)(=O)N1CCN(CC(F)(F)F)CC1
Show InChI InChI=1S/C28H36F4N6O3S/c1-2-3-10-33-27-34-16-22-23(17-38(26(22)35-27)20-5-7-21(39)8-6-20)19-4-9-25(24(29)15-19)42(40,41)37-13-11-36(12-14-37)18-28(30,31)32/h4,9,15-17,20-21,39H,2-3,5-8,10-14,18H2,1H3,(H,33,34,35)/t20-,21-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM350861
PNG
(UNC2371A | US10004755, Compound UNC2371A | US97956...)
Show SMILES CN1CCN(Cc2ccc(cc2)-c2cn(C3CC[C@H](O)CC3)c3nc(NCCC4CC4)ncc23)CC1
Show InChI InChI=1/C29H40N6O/c1-33-14-16-34(17-15-33)19-22-4-6-23(7-5-22)27-20-35(24-8-10-25(36)11-9-24)28-26(27)18-31-29(32-28)30-13-12-21-2-3-21/h4-7,18,20-21,24-25,36H,2-3,8-17,19H2,1H3,(H,30,31,32)/t24?,25-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM350843
PNG
(UNC1971A | US10004755, Compound UNC1971A | US97956...)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](N)CC3)c2n1)-c1ccc(c(F)c1)S(=O)(=O)N1CCOCC1
Show InChI InChI=1/C26H35FN6O3S/c1-2-3-10-29-26-30-16-21-22(17-33(25(21)31-26)20-7-5-19(28)6-8-20)18-4-9-24(23(27)15-18)37(34,35)32-11-13-36-14-12-32/h4,9,15-17,19-20H,2-3,5-8,10-14,28H2,1H3,(H,29,30,31)/t19-,20?
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM401014
PNG
(US10004755, Compound UNC4320A)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(NC2CCCN(C)CC2)cc1
Show InChI InChI=1S/C29H42N6O/c1-3-4-16-30-29-31-19-26-27(20-35(28(26)33-29)24-11-13-25(36)14-12-24)21-7-9-23(10-8-21)32-22-6-5-17-34(2)18-15-22/h7-10,19-20,22,24-25,32,36H,3-6,11-18H2,1-2H3,(H,30,31,33)/t22?,24?,25-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM350845
PNG
(UNC2025A | US10004755, Compound UNC2025A | US97956...)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(CN2CCN(C)CC2)cc1
Show InChI InChI=1/C28H40N6O/c1-3-4-13-29-28-30-18-25-26(20-34(27(25)31-28)23-9-11-24(35)12-10-23)22-7-5-21(6-8-22)19-33-16-14-32(2)15-17-33/h5-8,18,20,23-24,35H,3-4,9-17,19H2,1-2H3,(H,29,30,31)/t23?,24-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM401016
PNG
(US10004755, Compound UNC4218A)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(CN2CCCN(C)CC2)cc1
Show InChI InChI=1S/C29H42N6O/c1-3-4-14-30-29-31-19-26-27(21-35(28(26)32-29)24-10-12-25(36)13-11-24)23-8-6-22(7-9-23)20-34-16-5-15-33(2)17-18-34/h6-9,19,21,24-25,36H,3-5,10-18,20H2,1-2H3,(H,30,31,32)/t24?,25-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM401011
PNG
(US10004755, Compound UNC4309A)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(NC2CCCCC2)cc1
Show InChI InChI=1S/C28H39N5O/c1-2-3-17-29-28-30-18-25-26(19-33(27(25)32-28)23-13-15-24(34)16-14-23)20-9-11-22(12-10-20)31-21-7-5-4-6-8-21/h9-12,18-19,21,23-24,31,34H,2-8,13-17H2,1H3,(H,29,30,32)/t23?,24-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM350865
PNG
(UNC1667A | US10004755, Compound UNC1667A | US97956...)
Show SMILES CCCCNc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N1CCN(C)CC1
Show InChI InChI=1/C27H38N6O3S/c1-3-4-13-28-27-29-18-24-25(19-33(26(24)30-27)21-7-9-22(34)10-8-21)20-5-11-23(12-6-20)37(35,36)32-16-14-31(2)15-17-32/h5-6,11-12,18-19,21-22,34H,3-4,7-10,13-17H2,1-2H3,(H,28,29,30)/t21-,22-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM350844
PNG
(UNC1972A | US10004755, Compound UNC1972A | US97956...)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](N)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N1CCOCC1
Show InChI InChI=1/C26H36N6O3S/c1-2-3-12-28-26-29-17-23-24(18-32(25(23)30-26)21-8-6-20(27)7-9-21)19-4-10-22(11-5-19)36(33,34)31-13-15-35-16-14-31/h4-5,10-11,17-18,20-21H,2-3,6-9,12-16,27H2,1H3,(H,28,29,30)/t20-,21?
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM350861
PNG
(UNC2371A | US10004755, Compound UNC2371A | US97956...)
Show SMILES CN1CCN(Cc2ccc(cc2)-c2cn(C3CC[C@H](O)CC3)c3nc(NCCC4CC4)ncc23)CC1
Show InChI InChI=1/C29H40N6O/c1-33-14-16-34(17-15-33)19-22-4-6-23(7-5-22)27-20-35(24-8-10-25(36)11-9-24)28-26(27)18-31-29(32-28)30-13-12-21-2-3-21/h4-7,18,20-21,24-25,36H,2-3,8-17,19H2,1H3,(H,30,31,32)/t24?,25-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM401013
PNG
(US10004755, Compound UNC4319A)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(NC2CCCNCC2)cc1
Show InChI InChI=1S/C28H40N6O/c1-2-3-16-30-28-31-18-25-26(19-34(27(25)33-28)23-10-12-24(35)13-11-23)20-6-8-22(9-7-20)32-21-5-4-15-29-17-14-21/h6-9,18-19,21,23-24,29,32,35H,2-5,10-17H2,1H3,(H,30,31,33)/t21?,23?,24-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM350855
PNG
(UNC2143A | US10004755, Compound UNC2143A | US97956...)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(CN2CCNCC2)cc1
Show InChI InChI=1/C27H38N6O/c1-2-3-12-29-27-30-17-24-25(19-33(26(24)31-27)22-8-10-23(34)11-9-22)21-6-4-20(5-7-21)18-32-15-13-28-14-16-32/h4-7,17,19,22-23,28,34H,2-3,8-16,18H2,1H3,(H,29,30,31)/t22?,23-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM350845
PNG
(UNC2025A | US10004755, Compound UNC2025A | US97956...)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(CN2CCN(C)CC2)cc1
Show InChI InChI=1/C28H40N6O/c1-3-4-13-29-28-30-18-25-26(20-34(27(25)31-28)23-9-11-24(35)12-10-23)22-7-5-21(6-8-22)19-33-16-14-32(2)15-17-33/h5-8,18,20,23-24,35H,3-4,9-17,19H2,1-2H3,(H,29,30,31)/t23?,24-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM350865
PNG
(UNC1667A | US10004755, Compound UNC1667A | US97956...)
Show SMILES CCCCNc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N1CCN(C)CC1
Show InChI InChI=1/C27H38N6O3S/c1-3-4-13-28-27-29-18-24-25(19-33(26(24)30-27)21-7-9-22(34)10-8-21)20-5-11-23(12-6-20)37(35,36)32-16-14-31(2)15-17-32/h5-6,11-12,18-19,21-22,34H,3-4,7-10,13-17H2,1-2H3,(H,28,29,30)/t21-,22-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM350846
PNG
(UNC2026A | US10004755, Compound UNC2026A | US97956...)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)C1CCOCC1
Show InChI InChI=1/C27H36N4O4S/c1-2-3-14-28-27-29-17-24-25(18-31(26(24)30-27)20-6-8-21(32)9-7-20)19-4-10-22(11-5-19)36(33,34)23-12-15-35-16-13-23/h4-5,10-11,17-18,20-21,23,32H,2-3,6-9,12-16H2,1H3,(H,28,29,30)/t20?,21-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM50055498
PNG
(CHEMBL3326004 | US10004755, Compound UNC1669A | US...)
Show SMILES CCCCNc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(c(F)c1)S(=O)(=O)N1CCN(C)CC1
Show InChI InChI=1/C27H37FN6O3S/c1-3-4-11-29-27-30-17-22-23(18-34(26(22)31-27)20-6-8-21(35)9-7-20)19-5-10-25(24(28)16-19)38(36,37)33-14-12-32(2)13-15-33/h5,10,16-18,20-21,35H,3-4,6-9,11-15H2,1-2H3,(H,29,30,31)/t20-,21-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM401017
PNG
(US10004755, Compound UNC4291A)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)N1CCN(C)CC1
Show InChI InChI=1S/C27H38N6O/c1-3-4-13-28-27-29-18-24-25(19-33(26(24)30-27)22-9-11-23(34)12-10-22)20-5-7-21(8-6-20)32-16-14-31(2)15-17-32/h5-8,18-19,22-23,34H,3-4,9-17H2,1-2H3,(H,28,29,30)/t22?,23-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM350843
PNG
(UNC1971A | US10004755, Compound UNC1971A | US97956...)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](N)CC3)c2n1)-c1ccc(c(F)c1)S(=O)(=O)N1CCOCC1
Show InChI InChI=1/C26H35FN6O3S/c1-2-3-10-29-26-30-16-21-22(17-33(25(21)31-26)20-7-5-19(28)6-8-20)18-4-9-24(23(27)15-18)37(34,35)32-11-13-36-14-12-32/h4,9,15-17,19-20H,2-3,5-8,10-14,28H2,1H3,(H,29,30,31)/t19-,20?
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM350848
PNG
(UNC2078A | US10004755, Compound UNC2078A | US97956...)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N1CCCCC1
Show InChI InChI=1/C27H37N5O3S/c1-2-3-15-28-27-29-18-24-25(19-32(26(24)30-27)21-9-11-22(33)12-10-21)20-7-13-23(14-8-20)36(34,35)31-16-5-4-6-17-31/h7-8,13-14,18-19,21-22,33H,2-6,9-12,15-17H2,1H3,(H,28,29,30)/t21?,22-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM350842
PNG
(UNC1970A | US10004755, Compound UNC1970A | US97956...)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](N)CC3)c2n1)-c1ccc(F)cc1
Show InChI InChI=1/C22H28FN5/c1-2-3-12-25-22-26-13-19-20(15-4-6-16(23)7-5-15)14-28(21(19)27-22)18-10-8-17(24)9-11-18/h4-7,13-14,17-18H,2-3,8-12,24H2,1H3,(H,25,26,27)/t17-,18?
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM350855
PNG
(UNC2143A | US10004755, Compound UNC2143A | US97956...)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(CN2CCNCC2)cc1
Show InChI InChI=1/C27H38N6O/c1-2-3-12-29-27-30-17-24-25(19-33(26(24)31-27)22-8-10-23(34)11-9-22)21-6-4-20(5-7-21)18-32-15-13-28-14-16-32/h4-7,17,19,22-23,28,34H,2-3,8-16,18H2,1H3,(H,29,30,31)/t22?,23-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM401016
PNG
(US10004755, Compound UNC4218A)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(CN2CCCN(C)CC2)cc1
Show InChI InChI=1S/C29H42N6O/c1-3-4-14-30-29-31-19-26-27(21-35(28(26)32-29)24-10-12-25(36)13-11-24)23-8-6-22(7-9-23)20-34-16-5-15-33(2)17-18-34/h6-9,19,21,24-25,36H,3-5,10-18,20H2,1-2H3,(H,30,31,32)/t24?,25-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM401015
PNG
(US10004755, Compound UNC4321A)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(NC2CCCCCC2)cc1
Show InChI InChI=1S/C29H41N5O/c1-2-3-18-30-29-31-19-26-27(20-34(28(26)33-29)24-14-16-25(35)17-15-24)21-10-12-23(13-11-21)32-22-8-6-4-5-7-9-22/h10-13,19-20,22,24-25,32,35H,2-9,14-18H2,1H3,(H,30,31,33)/t24?,25-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM350848
PNG
(UNC2078A | US10004755, Compound UNC2078A | US97956...)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N1CCCCC1
Show InChI InChI=1/C27H37N5O3S/c1-2-3-15-28-27-29-18-24-25(19-32(26(24)30-27)21-9-11-22(33)12-10-21)20-7-13-23(14-8-20)36(34,35)31-16-5-4-6-17-31/h7-8,13-14,18-19,21-22,33H,2-6,9-12,15-17H2,1H3,(H,28,29,30)/t21?,22-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM401017
PNG
(US10004755, Compound UNC4291A)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)N1CCN(C)CC1
Show InChI InChI=1S/C27H38N6O/c1-3-4-13-28-27-29-18-24-25(19-33(26(24)30-27)22-9-11-23(34)12-10-22)20-5-7-21(8-6-20)32-16-14-31(2)15-17-32/h5-8,18-19,22-23,34H,3-4,9-17H2,1-2H3,(H,28,29,30)/t22?,23-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM401010
PNG
(US10004755, Compound UNC4308A)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(NC2CCNCC2)cc1
Show InChI InChI=1S/C27H38N6O/c1-2-3-14-29-27-30-17-24-25(18-33(26(24)32-27)22-8-10-23(34)11-9-22)19-4-6-20(7-5-19)31-21-12-15-28-16-13-21/h4-7,17-18,21-23,28,31,34H,2-3,8-16H2,1H3,(H,29,30,32)/t22?,23-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM350846
PNG
(UNC2026A | US10004755, Compound UNC2026A | US97956...)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)C1CCOCC1
Show InChI InChI=1/C27H36N4O4S/c1-2-3-14-28-27-29-17-24-25(18-31(26(24)30-27)20-6-8-21(32)9-7-20)19-4-10-22(11-5-19)36(33,34)23-12-15-35-16-13-23/h4-5,10-11,17-18,20-21,23,32H,2-3,6-9,12-16H2,1H3,(H,28,29,30)/t20?,21-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM350851
PNG
(UNC2123A | US10004755, Compound UNC2123A | US97956...)
Show SMILES N[C@H]1CCC(CC1)n1cc(-c2ccc(F)cc2)c2cnc(NCCC3CC3)nc12
Show InChI InChI=1/C23H28FN5/c24-17-5-3-16(4-6-17)21-14-29(19-9-7-18(25)8-10-19)22-20(21)13-27-23(28-22)26-12-11-15-1-2-15/h3-6,13-15,18-19H,1-2,7-12,25H2,(H,26,27,28)/t18-,19?
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM401013
PNG
(US10004755, Compound UNC4319A)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(NC2CCCNCC2)cc1
Show InChI InChI=1S/C28H40N6O/c1-2-3-16-30-28-31-18-25-26(19-34(27(25)33-28)23-10-12-24(35)13-11-23)20-6-8-22(9-7-20)32-21-5-4-15-29-17-14-21/h6-9,18-19,21,23-24,29,32,35H,2-5,10-17H2,1H3,(H,30,31,33)/t21?,23?,24-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM350856
PNG
(UNC2146A | US10004755, Compound UNC2146A | US97956...)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N1CC(F)(F)C1
Show InChI InChI=1/C25H31F2N5O3S/c1-2-3-12-28-24-29-13-21-22(14-32(23(21)30-24)18-6-8-19(33)9-7-18)17-4-10-20(11-5-17)36(34,35)31-15-25(26,27)16-31/h4-5,10-11,13-14,18-19,33H,2-3,6-9,12,15-16H2,1H3,(H,28,29,30)/t18?,19-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM350858
PNG
(UNC2367A | US10004755, Compound UNC2367A | US97956...)
Show SMILES CN1CCN(CC1)S(=O)(=O)c1ccc(-c2cn(C3CC[C@H](O)CC3)c3nc(NCCC4CC4)ncc23)c(F)c1
Show InChI InChI=1/C28H37FN6O3S/c1-33-12-14-34(15-13-33)39(37,38)22-8-9-23(26(29)16-22)25-18-35(20-4-6-21(36)7-5-20)27-24(25)17-31-28(32-27)30-11-10-19-2-3-19/h8-9,16-21,36H,2-7,10-15H2,1H3,(H,30,31,32)/t20?,21-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM401001
PNG
(US10004755, Compound UNC2396A)
Show SMILES CN1CCN(Cc2ccc(cc2)-c2cn(C3CC[C@H](O)CC3)c3nc(NCCCCO)ncc23)CC1
Show InChI InChI=1S/C28H40N6O2/c1-32-13-15-33(16-14-32)19-21-4-6-22(7-5-21)26-20-34(23-8-10-24(36)11-9-23)27-25(26)18-30-28(31-27)29-12-2-3-17-35/h4-7,18,20,23-24,35-36H,2-3,8-17,19H2,1H3,(H,29,30,31)/t23?,24-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM50055498
PNG
(CHEMBL3326004 | US10004755, Compound UNC1669A | US...)
Show SMILES CCCCNc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(c(F)c1)S(=O)(=O)N1CCN(C)CC1
Show InChI InChI=1/C27H37FN6O3S/c1-3-4-11-29-27-30-17-22-23(18-34(26(22)31-27)20-6-8-21(35)9-7-20)19-5-10-25(24(28)16-19)38(36,37)33-14-12-32(2)13-15-33/h5,10,16-18,20-21,35H,3-4,6-9,11-15H2,1-2H3,(H,29,30,31)/t20-,21-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM350847
PNG
(UNC2087A | US10004755, Compound UNC2087A | US97956...)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)C1CCCC1
Show InChI InChI=1/C27H36N4O3S/c1-2-3-16-28-27-29-17-24-25(18-31(26(24)30-27)20-10-12-21(32)13-11-20)19-8-14-23(15-9-19)35(33,34)22-6-4-5-7-22/h8-9,14-15,17-18,20-22,32H,2-7,10-13,16H2,1H3,(H,28,29,30)/t20?,21-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM350856
PNG
(UNC2146A | US10004755, Compound UNC2146A | US97956...)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N1CC(F)(F)C1
Show InChI InChI=1/C25H31F2N5O3S/c1-2-3-12-28-24-29-13-21-22(14-32(23(21)30-24)18-6-8-19(33)9-7-18)17-4-10-20(11-5-17)36(34,35)31-15-25(26,27)16-31/h4-5,10-11,13-14,18-19,33H,2-3,6-9,12,15-16H2,1H3,(H,28,29,30)/t18?,19-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM350847
PNG
(UNC2087A | US10004755, Compound UNC2087A | US97956...)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)C1CCCC1
Show InChI InChI=1/C27H36N4O3S/c1-2-3-16-28-27-29-17-24-25(18-31(26(24)30-27)20-10-12-21(32)13-11-20)19-8-14-23(15-9-19)35(33,34)22-6-4-5-7-22/h8-9,14-15,17-18,20-22,32H,2-7,10-13,16H2,1H3,(H,28,29,30)/t20?,21-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM350864
PNG
(UNC1666A | US10004755, Compound UNC1666A | US97956...)
Show SMILES CCCCNc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N1CCOCC1
Show InChI InChI=1/C26H35N5O4S/c1-2-3-12-27-26-28-17-23-24(18-31(25(23)29-26)20-6-8-21(32)9-7-20)19-4-10-22(11-5-19)36(33,34)30-13-15-35-16-14-30/h4-5,10-11,17-18,20-21,32H,2-3,6-9,12-16H2,1H3,(H,27,28,29)/t20-,21-
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n/an/a 41n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM401014
PNG
(US10004755, Compound UNC4320A)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(NC2CCCN(C)CC2)cc1
Show InChI InChI=1S/C29H42N6O/c1-3-4-16-30-29-31-19-26-27(20-35(28(26)33-29)24-11-13-25(36)14-12-24)21-7-9-23(10-8-21)32-22-6-5-17-34(2)18-15-22/h7-10,19-20,22,24-25,32,36H,3-6,11-18H2,1-2H3,(H,30,31,33)/t22?,24?,25-
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n/an/a 42n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM350864
PNG
(UNC1666A | US10004755, Compound UNC1666A | US97956...)
Show SMILES CCCCNc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N1CCOCC1
Show InChI InChI=1/C26H35N5O4S/c1-2-3-12-27-26-28-17-23-24(18-31(25(23)29-26)20-6-8-21(32)9-7-20)19-4-10-22(11-5-19)36(33,34)30-13-15-35-16-14-30/h4-5,10-11,17-18,20-21,32H,2-3,6-9,12-16H2,1H3,(H,27,28,29)/t20-,21-
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n/an/a 44n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM350853
PNG
(UNC2125A | US10004755, Compound UNC2125A | US97956...)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](N)CC3)c2n1)-c1ccc(F)c(F)c1
Show InChI InChI=1/C22H27F2N5/c1-2-3-10-26-22-27-12-17-18(14-4-9-19(23)20(24)11-14)13-29(21(17)28-22)16-7-5-15(25)6-8-16/h4,9,11-13,15-16H,2-3,5-8,10,25H2,1H3,(H,26,27,28)/t15-,16?
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n/an/a 44n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM401012
PNG
(US10004755, Compound UNC4311A)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(NC2CCN(C)CC2)cc1
Show InChI InChI=1S/C28H40N6O/c1-3-4-15-29-28-30-18-25-26(19-34(27(25)32-28)23-9-11-24(35)12-10-23)20-5-7-21(8-6-20)31-22-13-16-33(2)17-14-22/h5-8,18-19,22-24,31,35H,3-4,9-17H2,1-2H3,(H,29,30,32)/t23?,24-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM350858
PNG
(UNC2367A | US10004755, Compound UNC2367A | US97956...)
Show SMILES CN1CCN(CC1)S(=O)(=O)c1ccc(-c2cn(C3CC[C@H](O)CC3)c3nc(NCCC4CC4)ncc23)c(F)c1
Show InChI InChI=1/C28H37FN6O3S/c1-33-12-14-34(15-13-33)39(37,38)22-8-9-23(26(29)16-22)25-18-35(20-4-6-21(36)7-5-20)27-24(25)17-31-28(32-27)30-11-10-19-2-3-19/h8-9,16-21,36H,2-7,10-15H2,1H3,(H,30,31,32)/t20?,21-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM401014
PNG
(US10004755, Compound UNC4320A)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(NC2CCCN(C)CC2)cc1
Show InChI InChI=1S/C29H42N6O/c1-3-4-16-30-29-31-19-26-27(20-35(28(26)33-29)24-11-13-25(36)14-12-24)21-7-9-23(10-8-21)32-22-6-5-17-34(2)18-15-22/h7-10,19-20,22,24-25,32,36H,3-6,11-18H2,1-2H3,(H,30,31,33)/t22?,24?,25-
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n/an/a 49n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM350854
PNG
(UNC2142A | US10004755, Compound UNC2142A | US97956...)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(CN2CCOCC2)cc1
Show InChI InChI=1/C27H37N5O2/c1-2-3-12-28-27-29-17-24-25(19-32(26(24)30-27)22-8-10-23(33)11-9-22)21-6-4-20(5-7-21)18-31-13-15-34-16-14-31/h4-7,17,19,22-23,33H,2-3,8-16,18H2,1H3,(H,28,29,30)/t22?,23-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM401015
PNG
(US10004755, Compound UNC4321A)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(NC2CCCCCC2)cc1
Show InChI InChI=1S/C29H41N5O/c1-2-3-18-30-29-31-19-26-27(20-34(28(26)33-29)24-14-16-25(35)17-15-24)21-10-12-23(13-11-21)32-22-8-6-4-5-7-9-22/h10-13,19-20,22,24-25,32,35H,2-9,14-18H2,1H3,(H,30,31,33)/t24?,25-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM350854
PNG
(UNC2142A | US10004755, Compound UNC2142A | US97956...)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(CN2CCOCC2)cc1
Show InChI InChI=1/C27H37N5O2/c1-2-3-12-28-27-29-17-24-25(19-32(26(24)30-27)22-8-10-23(33)11-9-22)21-6-4-20(5-7-21)18-31-13-15-34-16-14-31/h4-7,17,19,22-23,33H,2-3,8-16,18H2,1H3,(H,28,29,30)/t22?,23-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM350868
PNG
(UNC1670A | US10004755, Compound UNC1670A | US97956...)
Show SMILES CCCCNc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(c(F)c1)S(=O)(=O)N1CCOCC1
Show InChI InChI=1/C26H34FN5O4S/c1-2-3-10-28-26-29-16-21-22(17-32(25(21)30-26)19-5-7-20(33)8-6-19)18-4-9-24(23(27)15-18)37(34,35)31-11-13-36-14-12-31/h4,9,15-17,19-20,33H,2-3,5-8,10-14H2,1H3,(H,28,29,30)/t19-,20-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM401010
PNG
(US10004755, Compound UNC4308A)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(NC2CCNCC2)cc1
Show InChI InChI=1S/C27H38N6O/c1-2-3-14-29-27-30-17-24-25(18-33(26(24)32-27)22-8-10-23(34)11-9-22)19-4-6-20(7-5-19)31-21-12-15-28-16-13-21/h4-7,17-18,21-23,28,31,34H,2-3,8-16H2,1H3,(H,29,30,32)/t22?,23-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM350850
PNG
(UNC2095A | US10004755, Compound UNC2095A | US97956...)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N1CCC(F)(F)CC1
Show InChI InChI=1/C27H35F2N5O3S/c1-2-3-14-30-26-31-17-23-24(18-34(25(23)32-26)20-6-8-21(35)9-7-20)19-4-10-22(11-5-19)38(36,37)33-15-12-27(28,29)13-16-33/h4-5,10-11,17-18,20-21,35H,2-3,6-9,12-16H2,1H3,(H,30,31,32)/t20?,21-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM350868
PNG
(UNC1670A | US10004755, Compound UNC1670A | US97956...)
Show SMILES CCCCNc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(c(F)c1)S(=O)(=O)N1CCOCC1
Show InChI InChI=1/C26H34FN5O4S/c1-2-3-10-28-26-29-16-21-22(17-32(25(21)30-26)19-5-7-20(33)8-6-19)18-4-9-24(23(27)15-18)37(34,35)31-11-13-36-14-12-31/h4,9,15-17,19-20,33H,2-3,5-8,10-14H2,1H3,(H,28,29,30)/t19-,20-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM350860
PNG
(UNC2370A | US10004755, Compound UNC2370A | US97956...)
Show SMILES O[C@H]1CCC(CC1)n1cc(-c2ccc(CN3CCOCC3)cc2)c2cnc(NCCC3CC3)nc12
Show InChI InChI=1/C28H37N5O2/c34-24-9-7-23(8-10-24)33-19-26(22-5-3-21(4-6-22)18-32-13-15-35-16-14-32)25-17-30-28(31-27(25)33)29-12-11-20-1-2-20/h3-6,17,19-20,23-24,34H,1-2,7-16,18H2,(H,29,30,31)/t23?,24-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM350852
PNG
(UNC2124A | US10004755, Compound UNC2124A | US97956...)
Show SMILES N[C@H]1CCC(CC1)n1cc(-c2ccc(F)cc2)c2cnc(NCCCCO)nc12
Show InChI InChI=1/C22H28FN5O/c23-16-5-3-15(4-6-16)20-14-28(18-9-7-17(24)8-10-18)21-19(20)13-26-22(27-21)25-11-1-2-12-29/h3-6,13-14,17-18,29H,1-2,7-12,24H2,(H,25,26,27)/t17-,18?
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM401018
PNG
(US10004755, Compound UNC4292A)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C28H32N4O2/c1-2-3-17-29-28-30-18-25-26(19-32(27(25)31-28)21-11-13-22(33)14-12-21)20-9-15-24(16-10-20)34-23-7-5-4-6-8-23/h4-10,15-16,18-19,21-22,33H,2-3,11-14,17H2,1H3,(H,29,30,31)/t21?,22-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM401012
PNG
(US10004755, Compound UNC4311A)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(NC2CCN(C)CC2)cc1
Show InChI InChI=1S/C28H40N6O/c1-3-4-15-29-28-30-18-25-26(19-34(27(25)32-28)23-9-11-24(35)12-10-23)20-5-7-21(8-6-20)31-22-13-16-33(2)17-14-22/h5-8,18-19,22-24,31,35H,3-4,9-17H2,1-2H3,(H,29,30,32)/t23?,24-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM401019
PNG
(US10004755, Compound UNC4310A)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(Nc2ccccc2)cc1
Show InChI InChI=1S/C28H33N5O/c1-2-3-17-29-28-30-18-25-26(19-33(27(25)32-28)23-13-15-24(34)16-14-23)20-9-11-22(12-10-20)31-21-7-5-4-6-8-21/h4-12,18-19,23-24,31,34H,2-3,13-17H2,1H3,(H,29,30,32)/t23?,24-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM350852
PNG
(UNC2124A | US10004755, Compound UNC2124A | US97956...)
Show SMILES N[C@H]1CCC(CC1)n1cc(-c2ccc(F)cc2)c2cnc(NCCCCO)nc12
Show InChI InChI=1/C22H28FN5O/c23-16-5-3-15(4-6-16)20-14-28(18-9-7-17(24)8-10-18)21-19(20)13-26-22(27-21)25-11-1-2-12-29/h3-6,13-14,17-18,29H,1-2,7-12,24H2,(H,25,26,27)/t17-,18?
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM401001
PNG
(US10004755, Compound UNC2396A)
Show SMILES CN1CCN(Cc2ccc(cc2)-c2cn(C3CC[C@H](O)CC3)c3nc(NCCCCO)ncc23)CC1
Show InChI InChI=1S/C28H40N6O2/c1-32-13-15-33(16-14-32)19-21-4-6-22(7-5-21)26-20-34(23-8-10-24(36)11-9-23)27-25(26)18-30-28(31-27)29-12-2-3-17-35/h4-7,18,20,23-24,35-36H,2-3,8-17,19H2,1H3,(H,29,30,31)/t23?,24-
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n/an/a 88n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM350842
PNG
(UNC1970A | US10004755, Compound UNC1970A | US97956...)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](N)CC3)c2n1)-c1ccc(F)cc1
Show InChI InChI=1/C22H28FN5/c1-2-3-12-25-22-26-13-19-20(15-4-6-16(23)7-5-15)14-28(21(19)27-22)18-10-8-17(24)9-11-18/h4-7,13-14,17-18H,2-3,8-12,24H2,1H3,(H,25,26,27)/t17-,18?
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM350851
PNG
(UNC2123A | US10004755, Compound UNC2123A | US97956...)
Show SMILES N[C@H]1CCC(CC1)n1cc(-c2ccc(F)cc2)c2cnc(NCCC3CC3)nc12
Show InChI InChI=1/C23H28FN5/c24-17-5-3-16(4-6-17)21-14-29(19-9-7-18(25)8-10-19)22-20(21)13-27-23(28-22)26-12-11-15-1-2-15/h3-6,13-15,18-19H,1-2,7-12,25H2,(H,26,27,28)/t18-,19?
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM350859
PNG
(UNC2368A | US10004755, Compound UNC2368A | US97956...)
Show SMILES O[C@H]1CCC(CC1)n1cc(-c2ccc(cc2F)S(=O)(=O)N2CCOCC2)c2cnc(NCCC3CC3)nc12
Show InChI InChI=1/C27H34FN5O4S/c28-25-15-21(38(35,36)32-11-13-37-14-12-32)7-8-22(25)24-17-33(19-3-5-20(34)6-4-19)26-23(24)16-30-27(31-26)29-10-9-18-1-2-18/h7-8,15-20,34H,1-6,9-14H2,(H,29,30,31)/t19?,20-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM350860
PNG
(UNC2370A | US10004755, Compound UNC2370A | US97956...)
Show SMILES O[C@H]1CCC(CC1)n1cc(-c2ccc(CN3CCOCC3)cc2)c2cnc(NCCC3CC3)nc12
Show InChI InChI=1/C28H37N5O2/c34-24-9-7-23(8-10-24)33-19-26(22-5-3-21(4-6-22)18-32-13-15-35-16-14-32)25-17-30-28(31-27(25)33)29-12-11-20-1-2-20/h3-6,17,19-20,23-24,34H,1-2,7-16,18H2,(H,29,30,31)/t23?,24-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM350849
PNG
(UNC2094A | US10004755, Compound UNC2094A | US97956...)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(F)c(F)c1
Show InChI InChI=1/C22H26F2N4O/c1-2-3-10-25-22-26-12-17-18(14-4-9-19(23)20(24)11-14)13-28(21(17)27-22)15-5-7-16(29)8-6-15/h4,9,11-13,15-16,29H,2-3,5-8,10H2,1H3,(H,25,26,27)/t15?,16-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM350859
PNG
(UNC2368A | US10004755, Compound UNC2368A | US97956...)
Show SMILES O[C@H]1CCC(CC1)n1cc(-c2ccc(cc2F)S(=O)(=O)N2CCOCC2)c2cnc(NCCC3CC3)nc12
Show InChI InChI=1/C27H34FN5O4S/c28-25-15-21(38(35,36)32-11-13-37-14-12-32)7-8-22(25)24-17-33(19-3-5-20(34)6-4-19)26-23(24)16-30-27(31-26)29-10-9-18-1-2-18/h7-8,15-20,34H,1-6,9-14H2,(H,29,30,31)/t19?,20-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM401000
PNG
(US10004755, Compound UNC2395A)
Show SMILES OCCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(CN2CCOCC2)cc1
Show InChI InChI=1S/C27H37N5O3/c33-14-2-1-11-28-27-29-17-24-25(19-32(26(24)30-27)22-7-9-23(34)10-8-22)21-5-3-20(4-6-21)18-31-12-15-35-16-13-31/h3-6,17,19,22-23,33-34H,1-2,7-16,18H2,(H,28,29,30)/t22?,23-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM350866
PNG
(UNC1668A | US10004755, Compound UNC1668A | US97956...)
Show SMILES CCCCNc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(N2CCOCC2)c(F)c1
Show InChI InChI=1/C26H34FN5O2/c1-2-3-10-28-26-29-16-21-22(17-32(25(21)30-26)19-5-7-20(33)8-6-19)18-4-9-24(23(27)15-18)31-11-13-34-14-12-31/h4,9,15-17,19-20,33H,2-3,5-8,10-14H2,1H3,(H,28,29,30)/t19-,20-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM350850
PNG
(UNC2095A | US10004755, Compound UNC2095A | US97956...)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N1CCC(F)(F)CC1
Show InChI InChI=1/C27H35F2N5O3S/c1-2-3-14-30-26-31-17-23-24(18-34(25(23)32-26)20-6-8-21(35)9-7-20)19-4-10-22(11-5-19)38(36,37)33-15-12-27(28,29)13-16-33/h4-5,10-11,17-18,20-21,35H,2-3,6-9,12-16H2,1H3,(H,30,31,32)/t20?,21-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM350857
PNG
(UNC2253A | US10004755, Compound UNC2253A | US97956...)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)C1(CC1)N1CCOCC1
Show InChI InChI=1/C29H39N5O2/c1-2-3-14-30-28-31-19-25-26(20-34(27(25)32-28)23-8-10-24(35)11-9-23)21-4-6-22(7-5-21)29(12-13-29)33-15-17-36-18-16-33/h4-7,19-20,23-24,35H,2-3,8-18H2,1H3,(H,30,31,32)/t23?,24-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM401002
PNG
(US10004755, Compound UNC1651A)
Show SMILES CCCCNc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(c(F)c1)S(=O)(=O)N1CCN(CC(F)(F)F)CC1
Show InChI InChI=1S/C28H36F4N6O3S/c1-2-3-10-33-27-34-16-22-23(17-38(26(22)35-27)20-5-7-21(39)8-6-20)19-4-9-25(24(29)15-19)42(40,41)37-13-11-36(12-14-37)18-28(30,31)32/h4,9,15-17,20-21,39H,2-3,5-8,10-14,18H2,1H3,(H,33,34,35)/t20-,21-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM350866
PNG
(UNC1668A | US10004755, Compound UNC1668A | US97956...)
Show SMILES CCCCNc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(N2CCOCC2)c(F)c1
Show InChI InChI=1/C26H34FN5O2/c1-2-3-10-28-26-29-16-21-22(17-32(25(21)30-26)19-5-7-20(33)8-6-19)18-4-9-24(23(27)15-18)31-11-13-34-14-12-31/h4,9,15-17,19-20,33H,2-3,5-8,10-14H2,1H3,(H,28,29,30)/t19-,20-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM350853
PNG
(UNC2125A | US10004755, Compound UNC2125A | US97956...)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](N)CC3)c2n1)-c1ccc(F)c(F)c1
Show InChI InChI=1/C22H27F2N5/c1-2-3-10-26-22-27-12-17-18(14-4-9-19(23)20(24)11-14)13-29(21(17)28-22)16-7-5-15(25)6-8-16/h4,9,11-13,15-16H,2-3,5-8,10,25H2,1H3,(H,26,27,28)/t15-,16?
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM401019
PNG
(US10004755, Compound UNC4310A)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(Nc2ccccc2)cc1
Show InChI InChI=1S/C28H33N5O/c1-2-3-17-29-28-30-18-25-26(19-33(27(25)32-28)23-13-15-24(34)16-14-23)20-9-11-22(12-10-20)31-21-7-5-4-6-8-21/h4-12,18-19,23-24,31,34H,2-3,13-17H2,1H3,(H,29,30,32)/t23?,24-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM401000
PNG
(US10004755, Compound UNC2395A)
Show SMILES OCCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(CN2CCOCC2)cc1
Show InChI InChI=1S/C27H37N5O3/c33-14-2-1-11-28-27-29-17-24-25(19-32(26(24)30-27)22-7-9-23(34)10-8-22)21-5-3-20(4-6-21)18-31-12-15-35-16-13-31/h3-6,17,19,22-23,33-34H,1-2,7-16,18H2,(H,28,29,30)/t22?,23-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM401002
PNG
(US10004755, Compound UNC1651A)
Show SMILES CCCCNc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(c(F)c1)S(=O)(=O)N1CCN(CC(F)(F)F)CC1
Show InChI InChI=1S/C28H36F4N6O3S/c1-2-3-10-33-27-34-16-22-23(17-38(26(22)35-27)20-5-7-21(39)8-6-20)19-4-9-25(24(29)15-19)42(40,41)37-13-11-36(12-14-37)18-28(30,31)32/h4,9,15-17,20-21,39H,2-3,5-8,10-14,18H2,1H3,(H,33,34,35)/t20-,21-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM350857
PNG
(UNC2253A | US10004755, Compound UNC2253A | US97956...)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)C1(CC1)N1CCOCC1
Show InChI InChI=1/C29H39N5O2/c1-2-3-14-30-28-31-19-25-26(20-34(27(25)32-28)23-8-10-24(35)11-9-23)21-4-6-22(7-5-21)29(12-13-29)33-15-17-36-18-16-33/h4-7,19-20,23-24,35H,2-3,8-18H2,1H3,(H,30,31,32)/t23?,24-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM401018
PNG
(US10004755, Compound UNC4292A)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C28H32N4O2/c1-2-3-17-29-28-30-18-25-26(19-32(27(25)31-28)21-11-13-22(33)14-12-21)20-9-15-24(16-10-20)34-23-7-5-4-6-8-23/h4-10,15-16,18-19,21-22,33H,2-3,11-14,17H2,1H3,(H,29,30,31)/t21?,22-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM401003
PNG
(US10004755, Compound UNC1652A)
Show SMILES CCCCNc1ncc2c(cn([C@@H]3CC[C@H](O)CC3)c2n1)-c1ccc(c(F)c1)S(=O)(=O)N1CCN(CC(F)(F)F)CC1
Show InChI InChI=1S/C28H36F4N6O3S/c1-2-3-10-33-27-34-16-22-23(17-38(26(22)35-27)20-5-7-21(39)8-6-20)19-4-9-25(24(29)15-19)42(40,41)37-13-11-36(12-14-37)18-28(30,31)32/h4,9,15-17,20-21,39H,2-3,5-8,10-14,18H2,1H3,(H,33,34,35)/t20-,21+
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM350869
PNG
(UNC2369A | US10004755, Compound UNC2369A | US97956...)
Show SMILES CCCCN(C)c1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(CN2CCN(C)CC2)cc1
Show InChI InChI=1/C29H42N6O/c1-4-5-14-33(3)29-30-19-26-27(21-35(28(26)31-29)24-10-12-25(36)13-11-24)23-8-6-22(7-9-23)20-34-17-15-32(2)16-18-34/h6-9,19,21,24-25,36H,4-5,10-18,20H2,1-3H3/t24-,25-
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n/an/a 398n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM401011
PNG
(US10004755, Compound UNC4309A)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(NC2CCCCC2)cc1
Show InChI InChI=1S/C28H39N5O/c1-2-3-17-29-28-30-18-25-26(19-33(27(25)32-28)23-13-15-24(34)16-14-23)20-9-11-22(12-10-20)31-21-7-5-4-6-8-21/h9-12,18-19,21,23-24,31,34H,2-8,13-17H2,1H3,(H,29,30,32)/t23?,24-
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n/an/a 406n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM350849
PNG
(UNC2094A | US10004755, Compound UNC2094A | US97956...)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(F)c(F)c1
Show InChI InChI=1/C22H26F2N4O/c1-2-3-10-25-22-26-12-17-18(14-4-9-19(23)20(24)11-14)13-28(21(17)27-22)15-5-7-16(29)8-6-15/h4,9,11-13,15-16,29H,2-3,5-8,10H2,1H3,(H,25,26,27)/t15?,16-
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n/an/a 421n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM350869
PNG
(UNC2369A | US10004755, Compound UNC2369A | US97956...)
Show SMILES CCCCN(C)c1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(CN2CCN(C)CC2)cc1
Show InChI InChI=1/C29H42N6O/c1-4-5-14-33(3)29-30-19-26-27(21-35(28(26)31-29)24-10-12-25(36)13-11-24)23-8-6-22(7-9-23)20-34-17-15-32(2)16-18-34/h6-9,19,21,24-25,36H,4-5,10-18,20H2,1-3H3/t24-,25-
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n/an/a 483n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM401011
PNG
(US10004755, Compound UNC4309A)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(NC2CCCCC2)cc1
Show InChI InChI=1S/C28H39N5O/c1-2-3-17-29-28-30-18-25-26(19-33(27(25)32-28)23-13-15-24(34)16-14-23)20-9-11-22(12-10-20)31-21-7-5-4-6-8-21/h9-12,18-19,21,23-24,31,34H,2-8,13-17H2,1H3,(H,29,30,32)/t23?,24-
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n/an/a 533n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM401003
PNG
(US10004755, Compound UNC1652A)
Show SMILES CCCCNc1ncc2c(cn([C@@H]3CC[C@H](O)CC3)c2n1)-c1ccc(c(F)c1)S(=O)(=O)N1CCN(CC(F)(F)F)CC1
Show InChI InChI=1S/C28H36F4N6O3S/c1-2-3-10-33-27-34-16-22-23(17-38(26(22)35-27)20-5-7-21(39)8-6-20)19-4-9-25(24(29)15-19)42(40,41)37-13-11-36(12-14-37)18-28(30,31)32/h4,9,15-17,20-21,39H,2-3,5-8,10-14,18H2,1H3,(H,33,34,35)/t20-,21+
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM401018
PNG
(US10004755, Compound UNC4292A)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C28H32N4O2/c1-2-3-17-29-28-30-18-25-26(19-32(27(25)31-28)21-11-13-22(33)14-12-21)20-9-15-24(16-10-20)34-23-7-5-4-6-8-23/h4-10,15-16,18-19,21-22,33H,2-3,11-14,17H2,1H3,(H,29,30,31)/t21?,22-
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n/an/a 721n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM401015
PNG
(US10004755, Compound UNC4321A)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(NC2CCCCCC2)cc1
Show InChI InChI=1S/C29H41N5O/c1-2-3-18-30-29-31-19-26-27(20-34(28(26)33-29)24-14-16-25(35)17-15-24)21-10-12-23(13-11-21)32-22-8-6-4-5-7-9-22/h10-13,19-20,22,24-25,32,35H,2-9,14-18H2,1H3,(H,30,31,33)/t24?,25-
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n/an/a 747n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM401019
PNG
(US10004755, Compound UNC4310A)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(Nc2ccccc2)cc1
Show InChI InChI=1S/C28H33N5O/c1-2-3-17-29-28-30-18-25-26(19-33(27(25)32-28)23-13-15-24(34)16-14-23)20-9-11-22(12-10-20)31-21-7-5-4-6-8-21/h4-12,18-19,23-24,31,34H,2-3,13-17H2,1H3,(H,29,30,32)/t23?,24-
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n/an/a 1.06E+3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM401015
PNG
(US10004755, Compound UNC4321A)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(NC2CCCCCC2)cc1
Show InChI InChI=1S/C29H41N5O/c1-2-3-18-30-29-31-19-26-27(20-34(28(26)33-29)24-14-16-25(35)17-15-24)21-10-12-23(13-11-21)32-22-8-6-4-5-7-9-22/h10-13,19-20,22,24-25,32,35H,2-9,14-18H2,1H3,(H,30,31,33)/t24?,25-
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n/an/a 1.07E+3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM401019
PNG
(US10004755, Compound UNC4310A)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(Nc2ccccc2)cc1
Show InChI InChI=1S/C28H33N5O/c1-2-3-17-29-28-30-18-25-26(19-33(27(25)32-28)23-13-15-24(34)16-14-23)20-9-11-22(12-10-20)31-21-7-5-4-6-8-21/h4-12,18-19,23-24,31,34H,2-3,13-17H2,1H3,(H,29,30,32)/t23?,24-
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n/an/a 1.23E+3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM401018
PNG
(US10004755, Compound UNC4292A)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C28H32N4O2/c1-2-3-17-29-28-30-18-25-26(19-32(27(25)31-28)21-11-13-22(33)14-12-21)20-9-15-24(16-10-20)34-23-7-5-4-6-8-23/h4-10,15-16,18-19,21-22,33H,2-3,11-14,17H2,1H3,(H,29,30,31)/t21?,22-
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n/an/a 1.61E+3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM350869
PNG
(UNC2369A | US10004755, Compound UNC2369A | US97956...)
Show SMILES CCCCN(C)c1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(CN2CCN(C)CC2)cc1
Show InChI InChI=1/C29H42N6O/c1-4-5-14-33(3)29-30-19-26-27(21-35(28(26)31-29)24-10-12-25(36)13-11-24)23-8-6-22(7-9-23)20-34-17-15-32(2)16-18-34/h6-9,19,21,24-25,36H,4-5,10-18,20H2,1-3H3/t24-,25-
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n/an/a 3.95E+3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM350869
PNG
(UNC2369A | US10004755, Compound UNC2369A | US97956...)
Show SMILES CCCCN(C)c1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(CN2CCN(C)CC2)cc1
Show InChI InChI=1/C29H42N6O/c1-4-5-14-33(3)29-30-19-26-27(21-35(28(26)31-29)24-10-12-25(36)13-11-24)23-8-6-22(7-9-23)20-34-17-15-32(2)16-18-34/h6-9,19,21,24-25,36H,4-5,10-18,20H2,1-3H3/t24-,25-
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n/an/a 1.11E+4n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...


US Patent US10004755 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%