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Patent code US10005739

Compile Data Set for Download or QSAR

Found 214 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM401184
PNG
(8-Chloro-3-[(5-chloro-2-ethylsulfonylphenyl)methyl...)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1Cn1cnc2c(Cl)c(CN3CC[C@@H](CNC)C3)c(cc2c1=O)C(F)(F)F
Show InChI InChI=1S/C25H27Cl2F3N4O3S/c1-3-38(36,37)21-5-4-17(26)8-16(21)12-34-14-32-23-18(24(34)35)9-20(25(28,29)30)19(22(23)27)13-33-7-6-15(11-33)10-31-2/h4-5,8-9,14-15,31H,3,6-7,10-13H2,1-2H3/t15-/m0/s1
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n/an/a 11n/an/an/an/an/an/a



CHUGAI SEIYAKU KABUSHIKI KAISHA

US Patent


Assay Description
DDR1 binding activity was measured using the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporati...


US Patent US10005739 (2018)

More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM401038
PNG
(A-12 | US10005739, Example 164)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1Nn1cnc2c(Cl)cc(cc2c1=O)C(F)(F)F
Show InChI InChI=1S/C17H12Cl2F3N3O3S/c1-2-29(27,28)14-4-3-10(18)7-13(14)24-25-8-23-15-11(16(25)26)5-9(6-12(15)19)17(20,21)22/h3-8,24H,2H2,1H3
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n/an/a 12n/an/an/an/an/an/a



CHUGAI SEIYAKU KABUSHIKI KAISHA

US Patent


Assay Description
DDR1 binding activity was measured using the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporati...


US Patent US10005739 (2018)

More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM401041
PNG
(8-Chloro-3-(5-chloro-2-ethylsulfonylanilino)-6-(tr...)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1Nn1cnc2c(Cl)cc(OC(F)(F)F)cc2c1=O
Show InChI InChI=1S/C17H12Cl2F3N3O4S/c1-2-30(27,28)14-4-3-9(18)5-13(14)24-25-8-23-15-11(16(25)26)6-10(7-12(15)19)29-17(20,21)22/h3-8,24H,2H2,1H3
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n/an/a 13n/an/an/an/an/an/a



CHUGAI SEIYAKU KABUSHIKI KAISHA

US Patent


Assay Description
DDR1 binding activity was measured using the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporati...


US Patent US10005739 (2018)

More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM401230
PNG
(7-[[(3S)-3-Aminopiperidin-1-yl]methyl]-3-[(5-chlor...)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1Cn1cnc2cc(CN3CCC[C@H](N)C3)c(cc2c1=O)C(F)(F)F
Show InChI InChI=1S/C24H26ClF3N4O3S/c1-2-36(34,35)22-6-5-17(25)8-16(22)12-32-14-30-21-9-15(11-31-7-3-4-18(29)13-31)20(24(26,27)28)10-19(21)23(32)33/h5-6,8-10,14,18H,2-4,7,11-13,29H2,1H3/t18-/m0/s1
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n/an/a 13n/an/an/an/an/an/a



CHUGAI SEIYAKU KABUSHIKI KAISHA

US Patent


Assay Description
DDR1 binding activity was measured using the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporati...


US Patent US10005739 (2018)

More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM400987
PNG
(7-[[(3R)-3-Aminopiperidin-1-yl]methyl]-8-chloro-3-...)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1Cn1cnc2c(Cl)c(CN3CCC[C@@H](N)C3)c(cc2c1=O)C(F)(F)F
Show InChI InChI=1S/C24H25Cl2F3N4O3S/c1-2-37(35,36)20-6-5-15(25)8-14(20)10-33-13-31-22-17(23(33)34)9-19(24(27,28)29)18(21(22)26)12-32-7-3-4-16(30)11-32/h5-6,8-9,13,16H,2-4,7,10-12,30H2,1H3/t16-/m1/s1
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n/an/a 14n/an/an/an/an/an/a



CHUGAI SEIYAKU KABUSHIKI KAISHA

US Patent


Assay Description
DDR1 binding activity was measured using the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporati...


US Patent US10005739 (2018)

More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM401187
PNG
(8-Chloro-3-[(5-chloro-2-ethylsulfonylphenyl)methyl...)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1Cn1cnc2c(Cl)c(CN3CCC[C@H](C3)N(C)C)c(cc2c1=O)C(F)(F)F
Show InChI InChI=1S/C26H29Cl2F3N4O3S/c1-4-39(37,38)22-8-7-17(27)10-16(22)12-35-15-32-24-19(25(35)36)11-21(26(29,30)31)20(23(24)28)14-34-9-5-6-18(13-34)33(2)3/h7-8,10-11,15,18H,4-6,9,12-14H2,1-3H3/t18-/m1/s1
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n/an/a 14n/an/an/an/an/an/a



CHUGAI SEIYAKU KABUSHIKI KAISHA

US Patent


Assay Description
DDR1 binding activity was measured using the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporati...


US Patent US10005739 (2018)

More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM401197
PNG
(7-[[(3R)-3-(Aminomethyl)pyrrolidin-1-yl]methyl]-8-...)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1Cn1cnc2c(Cl)c(CN3CC[C@H](CN)C3)c(cc2c1=O)C(F)(F)F
Show InChI InChI=1S/C24H25Cl2F3N4O3S/c1-2-37(35,36)20-4-3-16(25)7-15(20)11-33-13-31-22-17(23(33)34)8-19(24(27,28)29)18(21(22)26)12-32-6-5-14(9-30)10-32/h3-4,7-8,13-14H,2,5-6,9-12,30H2,1H3/t14-/m1/s1
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n/an/a 14n/an/an/an/an/an/a



CHUGAI SEIYAKU KABUSHIKI KAISHA

US Patent


Assay Description
DDR1 binding activity was measured using the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporati...


US Patent US10005739 (2018)

More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM401050
PNG
(8-Chloro-3-(5-chloro-2-propylanilino)-6-(trifluoro...)
Show SMILES CCCc1ccc(Cl)cc1Nn1cnc2c(Cl)cc(cc2c1=O)C(F)(F)F
Show InChI InChI=1S/C18H14Cl2F3N3O/c1-2-3-10-4-5-12(19)8-15(10)25-26-9-24-16-13(17(26)27)6-11(7-14(16)20)18(21,22)23/h4-9,25H,2-3H2,1H3
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n/an/a 16n/an/an/an/an/an/a



CHUGAI SEIYAKU KABUSHIKI KAISHA

US Patent


Assay Description
DDR1 binding activity was measured using the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporati...


US Patent US10005739 (2018)

More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM401204
PNG
((2R)-1-[[8-Chloro-3-[(5-chloro-2-ethylsulfonylphen...)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1Cn1cnc2c(Cl)c(CN3CCC[C@@H]3C(N)=O)c(cc2c1=O)C(F)(F)F
Show InChI InChI=1S/C24H23Cl2F3N4O4S/c1-2-38(36,37)19-6-5-14(25)8-13(19)10-33-12-31-21-15(23(33)35)9-17(24(27,28)29)16(20(21)26)11-32-7-3-4-18(32)22(30)34/h5-6,8-9,12,18H,2-4,7,10-11H2,1H3,(H2,30,34)/t18-/m1/s1
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n/an/a 16n/an/an/an/an/an/a



CHUGAI SEIYAKU KABUSHIKI KAISHA

US Patent


Assay Description
DDR1 binding activity was measured using the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporati...


US Patent US10005739 (2018)

More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM401147
PNG
(3-[(5-Chloro-2-ethylsulfonylphenyl)methyl]-7-[[(3R...)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1Cn1cnc2cc(CN3CC[C@H](C3)N(C)C)c(cc2c1=O)C(F)(F)F
Show InChI InChI=1S/C25H28ClF3N4O3S/c1-4-37(35,36)23-6-5-18(26)9-17(23)13-33-15-30-22-10-16(12-32-8-7-19(14-32)31(2)3)21(25(27,28)29)11-20(22)24(33)34/h5-6,9-11,15,19H,4,7-8,12-14H2,1-3H3/t19-/m1/s1
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n/an/a 18n/an/an/an/an/an/a



CHUGAI SEIYAKU KABUSHIKI KAISHA

US Patent


Assay Description
DDR1 binding activity was measured using the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporati...


US Patent US10005739 (2018)

More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM401042
PNG
(A-47 | US10005739, Example 201)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1Nn1cnc2c(Br)cc(OC(F)(F)F)cc2c1=O
Show InChI InChI=1S/C17H12BrClF3N3O4S/c1-2-30(27,28)14-4-3-9(19)5-13(14)24-25-8-23-15-11(16(25)26)6-10(7-12(15)18)29-17(20,21)22/h3-8,24H,2H2,1H3
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n/an/a 18n/an/an/an/an/an/a



CHUGAI SEIYAKU KABUSHIKI KAISHA

US Patent


Assay Description
DDR1 binding activity was measured using the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporati...


US Patent US10005739 (2018)

More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM401055
PNG
(8-Chloro-3-[5-chloro-2-(cyclopentylmethyl)anilino]...)
Show SMILES FC(F)(F)c1cc(Cl)c2ncn(Nc3cc(Cl)ccc3CC3CCCC3)c(=O)c2c1
Show InChI InChI=1S/C21H18Cl2F3N3O/c22-15-6-5-13(7-12-3-1-2-4-12)18(10-15)28-29-11-27-19-16(20(29)30)8-14(9-17(19)23)21(24,25)26/h5-6,8-12,28H,1-4,7H2
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n/an/a 19n/an/an/an/an/an/a



CHUGAI SEIYAKU KABUSHIKI KAISHA

US Patent


Assay Description
DDR1 binding activity was measured using the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporati...


US Patent US10005739 (2018)

More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM401084
PNG
(5-Bromo-2-[(5-chloro-2-ethylsulfonylphenyl)methyl]...)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1Cn1ccc2c(Br)cc(cc2c1=O)C(F)(F)F
Show InChI InChI=1S/C19H14BrClF3NO3S/c1-2-29(27,28)17-4-3-13(21)7-11(17)10-25-6-5-14-15(18(25)26)8-12(9-16(14)20)19(22,23)24/h3-9H,2,10H2,1H3
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n/an/a 20n/an/an/an/an/an/a



CHUGAI SEIYAKU KABUSHIKI KAISHA

US Patent


Assay Description
DDR1 binding activity was measured using the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporati...


US Patent US10005739 (2018)

More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM401210
PNG
(7-[[(3R)-3-Aminopyrrolidin-1-yl]methyl]-8-bromo-3-...)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1Cn1cnc2c(Br)c(CN3CC[C@@H](N)C3)c(cc2c1=O)C(F)(F)F
Show InChI InChI=1S/C23H23BrClF3N4O3S/c1-2-36(34,35)19-4-3-14(25)7-13(19)9-32-12-30-21-16(22(32)33)8-18(23(26,27)28)17(20(21)24)11-31-6-5-15(29)10-31/h3-4,7-8,12,15H,2,5-6,9-11,29H2,1H3/t15-/m1/s1
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n/an/a 20n/an/an/an/an/an/a



CHUGAI SEIYAKU KABUSHIKI KAISHA

US Patent


Assay Description
DDR1 binding activity was measured using the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporati...


US Patent US10005739 (2018)

More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM401232
PNG
(7-[[(3S)-3-(2-Aminoethylamino)piperidin-1-yl]methy...)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1Cn1cnc2c(Cl)c(CN3CCC[C@@H](C3)NCCN)c(cc2c1=O)C(F)(F)F
Show InChI InChI=1S/C26H30Cl2F3N5O3S/c1-2-40(38,39)22-6-5-17(27)10-16(22)12-36-15-34-24-19(25(36)37)11-21(26(29,30)31)20(23(24)28)14-35-9-3-4-18(13-35)33-8-7-32/h5-6,10-11,15,18,33H,2-4,7-9,12-14,32H2,1H3/t18-/m0/s1
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CHUGAI SEIYAKU KABUSHIKI KAISHA

US Patent


Assay Description
DDR1 binding activity was measured using the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporati...


US Patent US10005739 (2018)

More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM401237
PNG
(7-[[(3R)-3-Aminopyrrolidin-1-yl]methyl]-3-[(5-chlo...)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1Cn1cnc2c(C#N)c(CN3CC[C@@H](N)C3)c(cc2c1=O)C(F)(F)F
Show InChI InChI=1S/C24H23ClF3N5O3S/c1-2-37(35,36)21-4-3-15(25)7-14(21)10-33-13-31-22-17(23(33)34)8-20(24(26,27)28)19(18(22)9-29)12-32-6-5-16(30)11-32/h3-4,7-8,13,16H,2,5-6,10-12,30H2,1H3/t16-/m1/s1
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n/an/a 21n/an/an/an/an/an/a



CHUGAI SEIYAKU KABUSHIKI KAISHA

US Patent


Assay Description
DDR1 binding activity was measured using the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporati...


US Patent US10005739 (2018)

More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM400986
PNG
(8-Chloro-3-[(5-chloro-2-ethylsulfonylphenyl)methyl...)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1Cn1cnc2c(Cl)c(CN3CCC[C@H](C3)NC)c(cc2c1=O)C(F)(F)F
Show InChI InChI=1S/C25H27Cl2F3N4O3S/c1-3-38(36,37)21-7-6-16(26)9-15(21)11-34-14-32-23-18(24(34)35)10-20(25(28,29)30)19(22(23)27)13-33-8-4-5-17(12-33)31-2/h6-7,9-10,14,17,31H,3-5,8,11-13H2,1-2H3/t17-/m1/s1
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n/an/a 22n/an/an/an/an/an/a



CHUGAI SEIYAKU KABUSHIKI KAISHA

US Patent


Assay Description
DDR1 binding activity was measured using the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporati...


US Patent US10005739 (2018)

More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM401233
PNG
(7-[[(3S)-3-[Bis(2-aminoethyl)amino]piperidin-1-yl]...)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1Cn1cnc2c(Cl)c(CN3CCC[C@@H](C3)N(CCN)CCN)c(cc2c1=O)C(F)(F)F
Show InChI InChI=1S/C28H35Cl2F3N6O3S/c1-2-43(41,42)24-6-5-19(29)12-18(24)14-39-17-36-26-21(27(39)40)13-23(28(31,32)33)22(25(26)30)16-37-9-3-4-20(15-37)38(10-7-34)11-8-35/h5-6,12-13,17,20H,2-4,7-11,14-16,34-35H2,1H3/t20-/m0/s1
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n/an/a 22n/an/an/an/an/an/a



CHUGAI SEIYAKU KABUSHIKI KAISHA

US Patent


Assay Description
DDR1 binding activity was measured using the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporati...


US Patent US10005739 (2018)

More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM401146
PNG
(7-[[(3R)-3-Aminopyrrolidin-1-yl]methyl]-3-[(5-chlo...)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1Cn1cnc2cc(CN3CC[C@@H](N)C3)c(cc2c1=O)C(F)(F)F
Show InChI InChI=1S/C23H24ClF3N4O3S/c1-2-35(33,34)21-4-3-16(24)7-15(21)11-31-13-29-20-8-14(10-30-6-5-17(28)12-30)19(23(25,26)27)9-18(20)22(31)32/h3-4,7-9,13,17H,2,5-6,10-12,28H2,1H3/t17-/m1/s1
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n/an/a 23n/an/an/an/an/an/a



CHUGAI SEIYAKU KABUSHIKI KAISHA

US Patent


Assay Description
DDR1 binding activity was measured using the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporati...


US Patent US10005739 (2018)

More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM401198
PNG
(8-Chloro-3-[(5-chloro-2-ethylsulfonylphenyl)methyl...)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1Cn1cnc2c(Cl)c(CN3CC[C@H](CN(C)C)C3)c(cc2c1=O)C(F)(F)F
Show InChI InChI=1S/C26H29Cl2F3N4O3S/c1-4-39(37,38)22-6-5-18(27)9-17(22)13-35-15-32-24-19(25(35)36)10-21(26(29,30)31)20(23(24)28)14-34-8-7-16(12-34)11-33(2)3/h5-6,9-10,15-16H,4,7-8,11-14H2,1-3H3/t16-/m1/s1
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n/an/a 23n/an/an/an/an/an/a



CHUGAI SEIYAKU KABUSHIKI KAISHA

US Patent


Assay Description
DDR1 binding activity was measured using the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporati...


US Patent US10005739 (2018)

More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM401064
PNG
(E-13 | US10005739, Example 354)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1Cn1cnc2c(Cl)cc(cc2c1=O)C(F)(F)F
Show InChI InChI=1S/C18H13Cl2F3N2O3S/c1-2-29(27,28)15-4-3-12(19)5-10(15)8-25-9-24-16-13(17(25)26)6-11(7-14(16)20)18(21,22)23/h3-7,9H,2,8H2,1H3
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CHUGAI SEIYAKU KABUSHIKI KAISHA

US Patent


Assay Description
DDR1 binding activity was measured using the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporati...


US Patent US10005739 (2018)

More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM401200
PNG
(1-[[8-Chloro-3-[(5-chloro-2-ethylsulfonylphenyl)me...)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1Cn1cnc2c(Cl)c(CN3CCC(C3)C(N)=O)c(cc2c1=O)C(F)(F)F
Show InChI InChI=1S/C24H23Cl2F3N4O4S/c1-2-38(36,37)19-4-3-15(25)7-14(19)10-33-12-31-21-16(23(33)35)8-18(24(27,28)29)17(20(21)26)11-32-6-5-13(9-32)22(30)34/h3-4,7-8,12-13H,2,5-6,9-11H2,1H3,(H2,30,34)
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CHUGAI SEIYAKU KABUSHIKI KAISHA

US Patent


Assay Description
DDR1 binding activity was measured using the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporati...


US Patent US10005739 (2018)

More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM401178
PNG
(7-[[(3R)-3-Aminopyrrolidin-1-yl]methyl]-8-chloro-3...)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1Cn1cnc2c(Cl)c(CN3CC[C@@H](N)C3)c(cc2c1=O)C(F)(F)F
Show InChI InChI=1S/C23H23Cl2F3N4O3S/c1-2-36(34,35)19-4-3-14(24)7-13(19)9-32-12-30-21-16(22(32)33)8-18(23(26,27)28)17(20(21)25)11-31-6-5-15(29)10-31/h3-4,7-8,12,15H,2,5-6,9-11,29H2,1H3/t15-/m1/s1
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CHUGAI SEIYAKU KABUSHIKI KAISHA

US Patent


Assay Description
DDR1 binding activity was measured using the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporati...


US Patent US10005739 (2018)

More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM401037
PNG
(8-Chloro-3-[(5-chloro-2-ethylsulfonylphenyl)methyl...)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1Cn1cnc2c(Cl)c(CN3CCC[C@@H](C3)NC)c(cc2c1=O)C(F)(F)F
Show InChI InChI=1S/C25H27Cl2F3N4O3S/c1-3-38(36,37)21-7-6-16(26)9-15(21)11-34-14-32-23-18(24(34)35)10-20(25(28,29)30)19(22(23)27)13-33-8-4-5-17(12-33)31-2/h6-7,9-10,14,17,31H,3-5,8,11-13H2,1-2H3/t17-/m0/s1
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CHUGAI SEIYAKU KABUSHIKI KAISHA

US Patent


Assay Description
DDR1 binding activity was measured using the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporati...


US Patent US10005739 (2018)

More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM401083
PNG
(5-Chloro-2-[(5-chloro-2-ethylsulfonylphenyl)methyl...)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1Cn1ccc2c(Cl)cc(cc2c1=O)C(F)(F)F
Show InChI InChI=1S/C19H14Cl2F3NO3S/c1-2-29(27,28)17-4-3-13(20)7-11(17)10-25-6-5-14-15(18(25)26)8-12(9-16(14)21)19(22,23)24/h3-9H,2,10H2,1H3
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CHUGAI SEIYAKU KABUSHIKI KAISHA

US Patent


Assay Description
DDR1 binding activity was measured using the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporati...


US Patent US10005739 (2018)

More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM401040
PNG
(A-26 | US10005739, Example 170)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1Nn1cnc2c(C)cc(Br)cc2c1=O
Show InChI InChI=1S/C17H15BrClN3O3S/c1-3-26(24,25)15-5-4-12(19)8-14(15)21-22-9-20-16-10(2)6-11(18)7-13(16)17(22)23/h4-9,21H,3H2,1-2H3
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CHUGAI SEIYAKU KABUSHIKI KAISHA

US Patent


Assay Description
DDR1 binding activity was measured using the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporati...


US Patent US10005739 (2018)

More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM401221
PNG
(7-[[(3R)-3-Aminopyrrolidin-1-yl]methyl]-8-chloro-3...)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1Cn1cnc2c(Cl)c(CN3CC[C@@H](N)C3)c(OC(F)(F)F)cc2c1=O
Show InChI InChI=1S/C23H23Cl2F3N4O4S/c1-2-37(34,35)19-4-3-14(24)7-13(19)9-32-12-30-21-16(22(32)33)8-18(36-23(26,27)28)17(20(21)25)11-31-6-5-15(29)10-31/h3-4,7-8,12,15H,2,5-6,9-11,29H2,1H3/t15-/m1/s1
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CHUGAI SEIYAKU KABUSHIKI KAISHA

US Patent


Assay Description
DDR1 binding activity was measured using the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporati...


US Patent US10005739 (2018)

More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM401127
PNG
(H-37 | US10005739, Example 432)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1Nn1cnc2cc(CN3CCC(C3)N3CCCCC3)c(Br)cc2c1=O
Show InChI InChI=1S/C26H31BrClN5O3S/c1-2-37(35,36)25-7-6-19(28)13-24(25)30-33-17-29-23-12-18(22(27)14-21(23)26(33)34)15-31-11-8-20(16-31)32-9-4-3-5-10-32/h6-7,12-14,17,20,30H,2-5,8-11,15-16H2,1H3
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CHUGAI SEIYAKU KABUSHIKI KAISHA

US Patent


Assay Description
DDR1 binding activity was measured using the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporati...


US Patent US10005739 (2018)

More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM400999
PNG
(8-Chloro-3-[(5-chloro-2-ethylsulfonylphenyl)methyl...)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1Cn1cnc2c(Cl)c(CN3CC[C@H](C3)NC)c(cc2c1=O)C(F)(F)F
Show InChI InChI=1S/C24H25Cl2F3N4O3S/c1-3-37(35,36)20-5-4-15(25)8-14(20)10-33-13-31-22-17(23(33)34)9-19(24(27,28)29)18(21(22)26)12-32-7-6-16(11-32)30-2/h4-5,8-9,13,16,30H,3,6-7,10-12H2,1-2H3/t16-/m1/s1
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CHUGAI SEIYAKU KABUSHIKI KAISHA

US Patent


Assay Description
DDR1 binding activity was measured using the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporati...


US Patent US10005739 (2018)

More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM401185
PNG
(7-[[(3S)-3-(Aminomethyl)pyrrolidin-1-yl]methyl]-8-...)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1Cn1cnc2c(Cl)c(CN3CC[C@@H](CN)C3)c(cc2c1=O)C(F)(F)F
Show InChI InChI=1S/C24H25Cl2F3N4O3S/c1-2-37(35,36)20-4-3-16(25)7-15(20)11-33-13-31-22-17(23(33)34)8-19(24(27,28)29)18(21(22)26)12-32-6-5-14(9-30)10-32/h3-4,7-8,13-14H,2,5-6,9-12,30H2,1H3/t14-/m0/s1
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CHUGAI SEIYAKU KABUSHIKI KAISHA

US Patent


Assay Description
DDR1 binding activity was measured using the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporati...


US Patent US10005739 (2018)

More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM401224
PNG
(8-Chloro-3-[(5-chloro-2-ethylsulfonylphenyl)methyl...)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1Cn1cnc2c(Cl)c(CN3CC[C@@H](CNC)C3)c(OC(F)(F)F)cc2c1=O
Show InChI InChI=1S/C25H27Cl2F3N4O4S/c1-3-39(36,37)21-5-4-17(26)8-16(21)12-34-14-32-23-18(24(34)35)9-20(38-25(28,29)30)19(22(23)27)13-33-7-6-15(11-33)10-31-2/h4-5,8-9,14-15,31H,3,6-7,10-13H2,1-2H3/t15-/m0/s1
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CHUGAI SEIYAKU KABUSHIKI KAISHA

US Patent


Assay Description
DDR1 binding activity was measured using the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporati...


US Patent US10005739 (2018)

More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM401235
PNG
((2S)-2-Amino-N-[(3S)-1-[[8-chloro-3-[(5-chloro-2-e...)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1Cn1cnc2c(Cl)c(CN3CCC[C@@H](C3)NC(=O)[C@H](C)N)c(cc2c1=O)C(F)(F)F
Show InChI InChI=1S/C27H30Cl2F3N5O4S/c1-3-42(40,41)22-7-6-17(28)9-16(22)11-37-14-34-24-19(26(37)39)10-21(27(30,31)32)20(23(24)29)13-36-8-4-5-18(12-36)35-25(38)15(2)33/h6-7,9-10,14-15,18H,3-5,8,11-13,33H2,1-2H3,(H,35,38)/t15-,18-/m0/s1
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CHUGAI SEIYAKU KABUSHIKI KAISHA

US Patent


Assay Description
DDR1 binding activity was measured using the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporati...


US Patent US10005739 (2018)

More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM401035
PNG
(7-[[(3S)-3-Aminopiperidin-1-yl]methyl]-8-chloro-3-...)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1Cn1cnc2c(Cl)c(CN3CCC[C@H](N)C3)c(cc2c1=O)C(F)(F)F
Show InChI InChI=1S/C24H25Cl2F3N4O3S/c1-2-37(35,36)20-6-5-15(25)8-14(20)10-33-13-31-22-17(23(33)34)9-19(24(27,28)29)18(21(22)26)12-32-7-3-4-16(30)11-32/h5-6,8-9,13,16H,2-4,7,10-12,30H2,1H3/t16-/m0/s1
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CHUGAI SEIYAKU KABUSHIKI KAISHA

US Patent


Assay Description
DDR1 binding activity was measured using the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporati...


US Patent US10005739 (2018)

More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM401215
PNG
(3-[(5-Chloro-2-ethylsulfonylphenyl)methyl]-8-ethyl...)
Show SMILES CCc1c(CN2CCC[C@@H](C2)NC)c(cc2c1ncn(Cc1cc(Cl)ccc1S(=O)(=O)CC)c2=O)C(F)(F)F
Show InChI InChI=1S/C27H32ClF3N4O3S/c1-4-20-22(15-34-10-6-7-19(14-34)32-3)23(27(29,30)31)12-21-25(20)33-16-35(26(21)36)13-17-11-18(28)8-9-24(17)39(37,38)5-2/h8-9,11-12,16,19,32H,4-7,10,13-15H2,1-3H3/t19-/m0/s1
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CHUGAI SEIYAKU KABUSHIKI KAISHA

US Patent


Assay Description
DDR1 binding activity was measured using the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporati...


US Patent US10005739 (2018)

More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM401166
PNG
(2-Amino-3-[(5-chloro-2-ethylsulfonylphenyl)methyl]...)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1Cn1c(N)nc2c(CN3CCNCC3)cc(OC(F)(F)F)cc2c1=O
Show InChI InChI=1S/C23H25ClF3N5O4S/c1-2-37(34,35)19-4-3-16(24)9-14(19)13-32-21(33)18-11-17(36-23(25,26)27)10-15(20(18)30-22(32)28)12-31-7-5-29-6-8-31/h3-4,9-11,29H,2,5-8,12-13H2,1H3,(H2,28,30)
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CHUGAI SEIYAKU KABUSHIKI KAISHA

US Patent


Assay Description
DDR1 binding activity was measured using the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporati...


US Patent US10005739 (2018)

More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM401223
PNG
(7-[[(3S)-3-(Aminomethyl)pyrrolidin-1-yl]methyl]-8-...)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1Cn1cnc2c(Cl)c(CN3CC[C@@H](CN)C3)c(OC(F)(F)F)cc2c1=O
Show InChI InChI=1S/C24H25Cl2F3N4O4S/c1-2-38(35,36)20-4-3-16(25)7-15(20)11-33-13-31-22-17(23(33)34)8-19(37-24(27,28)29)18(21(22)26)12-32-6-5-14(9-30)10-32/h3-4,7-8,13-14H,2,5-6,9-12,30H2,1H3/t14-/m0/s1
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CHUGAI SEIYAKU KABUSHIKI KAISHA

US Patent


Assay Description
DDR1 binding activity was measured using the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporati...


US Patent US10005739 (2018)

More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM400982
PNG
(6-Bromo-3-(5-chloro-2-ethylsulfonylanilino)-7-(pip...)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1Nn1cnc2cc(CN3CCNCC3)c(Br)cc2c1=O
Show InChI InChI=1S/C21H23BrClN5O3S/c1-2-32(30,31)20-4-3-15(23)10-19(20)26-28-13-25-18-9-14(12-27-7-5-24-6-8-27)17(22)11-16(18)21(28)29/h3-4,9-11,13,24,26H,2,5-8,12H2,1H3
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n/an/a 30n/an/an/an/an/an/a



CHUGAI SEIYAKU KABUSHIKI KAISHA

US Patent


Assay Description
DDR1 binding activity was measured using the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporati...


US Patent US10005739 (2018)

More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM401238
PNG
(N-[(3R)-1-[[3-[(5-Chloro-2-ethylsulfonylphenyl)met...)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1Cn1cnc2c(C#N)c(CN3CC[C@H](C3)NS(C)(=O)=O)c(cc2c1=O)C(F)(F)F
Show InChI InChI=1S/C25H25ClF3N5O5S2/c1-3-41(38,39)22-5-4-16(26)8-15(22)11-34-14-31-23-18(24(34)35)9-21(25(27,28)29)20(19(23)10-30)13-33-7-6-17(12-33)32-40(2,36)37/h4-5,8-9,14,17,32H,3,6-7,11-13H2,1-2H3/t17-/m1/s1
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CHUGAI SEIYAKU KABUSHIKI KAISHA

US Patent


Assay Description
DDR1 binding activity was measured using the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporati...


US Patent US10005739 (2018)

More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM401044
PNG
(8-Bromo-3-(5-chloro-2-propan-2-ylsulfonylanilino)-...)
Show SMILES CC(C)S(=O)(=O)c1ccc(Cl)cc1Nn1cnc2c(Br)cc(cc2c1=O)C(F)(F)F
Show InChI InChI=1S/C18H14BrClF3N3O3S/c1-9(2)30(28,29)15-4-3-11(20)7-14(15)25-26-8-24-16-12(17(26)27)5-10(6-13(16)19)18(21,22)23/h3-9,25H,1-2H3
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n/an/a 31n/an/an/an/an/an/a



CHUGAI SEIYAKU KABUSHIKI KAISHA

US Patent


Assay Description
DDR1 binding activity was measured using the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporati...


US Patent US10005739 (2018)

More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM401214
PNG
(3-[(5-Chloro-2-ethylsulfonylphenyl)methyl]-8-methy...)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1Cn1cnc2c(C)c(CN3CCC[C@@H](C3)NC)c(cc2c1=O)C(F)(F)F
Show InChI InChI=1S/C26H30ClF3N4O3S/c1-4-38(36,37)23-8-7-18(27)10-17(23)12-34-15-32-24-16(2)21(14-33-9-5-6-19(13-33)31-3)22(26(28,29)30)11-20(24)25(34)35/h7-8,10-11,15,19,31H,4-6,9,12-14H2,1-3H3/t19-/m0/s1
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n/an/a 31n/an/an/an/an/an/a



CHUGAI SEIYAKU KABUSHIKI KAISHA

US Patent


Assay Description
DDR1 binding activity was measured using the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporati...


US Patent US10005739 (2018)

More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM401036
PNG
(8-Chloro-3-[(5-chloro-2-ethylsulfonylphenyl)methyl...)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1Cn1cnc2c(Cl)c(CN3CCC[C@@H](C3)N(C)C)c(cc2c1=O)C(F)(F)F
Show InChI InChI=1S/C26H29Cl2F3N4O3S/c1-4-39(37,38)22-8-7-17(27)10-16(22)12-35-15-32-24-19(25(35)36)11-21(26(29,30)31)20(23(24)28)14-34-9-5-6-18(13-34)33(2)3/h7-8,10-11,15,18H,4-6,9,12-14H2,1-3H3/t18-/m0/s1
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n/an/a 31n/an/an/an/an/an/a



CHUGAI SEIYAKU KABUSHIKI KAISHA

US Patent


Assay Description
DDR1 binding activity was measured using the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporati...


US Patent US10005739 (2018)

More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM401049
PNG
(8-Bromo-3-(5-chloro-2-cyclopropylsulfonylanilino)-...)
Show SMILES FC(F)(F)c1cc(Br)c2ncn(Nc3cc(Cl)ccc3S(=O)(=O)C3CC3)c(=O)c2c1
Show InChI InChI=1S/C18H12BrClF3N3O3S/c19-13-6-9(18(21,22)23)5-12-16(13)24-8-26(17(12)27)25-14-7-10(20)1-4-15(14)30(28,29)11-2-3-11/h1,4-8,11,25H,2-3H2
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n/an/a 32n/an/an/an/an/an/a



CHUGAI SEIYAKU KABUSHIKI KAISHA

US Patent


Assay Description
DDR1 binding activity was measured using the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporati...


US Patent US10005739 (2018)

More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM401141
PNG
(3-[(5-Chloro-2-ethylsulfonylphenyl)methyl]-7-[(4-m...)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1Cn1cnc2cc(CN3CCN(C)CC3)c(cc2c1=O)C(F)(F)F
Show InChI InChI=1S/C24H26ClF3N4O3S/c1-3-36(34,35)22-5-4-18(25)10-17(22)14-32-15-29-21-11-16(13-31-8-6-30(2)7-9-31)20(24(26,27)28)12-19(21)23(32)33/h4-5,10-12,15H,3,6-9,13-14H2,1-2H3
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n/an/a 32n/an/an/an/an/an/a



CHUGAI SEIYAKU KABUSHIKI KAISHA

US Patent


Assay Description
DDR1 binding activity was measured using the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporati...


US Patent US10005739 (2018)

More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM401091
PNG
(8-Chloro-3-(5-chloro-2-ethylsulfonylanilino)-7-(pi...)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1Nn1cnc2c(Cl)c(CN3CCNCC3)c(cc2c1=O)C(F)(F)F
Show InChI InChI=1S/C22H22Cl2F3N5O3S/c1-2-36(34,35)18-4-3-13(23)9-17(18)30-32-12-29-20-14(21(32)33)10-16(22(25,26)27)15(19(20)24)11-31-7-5-28-6-8-31/h3-4,9-10,12,28,30H,2,5-8,11H2,1H3
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n/an/a 33n/an/an/an/an/an/a



CHUGAI SEIYAKU KABUSHIKI KAISHA

US Patent


Assay Description
DDR1 binding activity was measured using the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporati...


US Patent US10005739 (2018)

More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM401222
PNG
(8-Chloro-3-[(5-chloro-2-ethylsulfonylphenyl)methyl...)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1Cn1cnc2c(Cl)c(CN3CC[C@H](C3)NC)c(OC(F)(F)F)cc2c1=O
Show InChI InChI=1S/C24H25Cl2F3N4O4S/c1-3-38(35,36)20-5-4-15(25)8-14(20)10-33-13-31-22-17(23(33)34)9-19(37-24(27,28)29)18(21(22)26)12-32-7-6-16(11-32)30-2/h4-5,8-9,13,16,30H,3,6-7,10-12H2,1-2H3/t16-/m1/s1
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n/an/a 33n/an/an/an/an/an/a



CHUGAI SEIYAKU KABUSHIKI KAISHA

US Patent


Assay Description
DDR1 binding activity was measured using the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporati...


US Patent US10005739 (2018)

More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM401176
PNG
(8-Chloro-3-[(5-chloro-2-ethylsulfonylphenyl)methyl...)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1Cn1cnc2c(Cl)c(CN3CCN(CC3)C(C)C)c(cc2c1=O)C(F)(F)F
Show InChI InChI=1S/C26H29Cl2F3N4O3S/c1-4-39(37,38)22-6-5-18(27)11-17(22)13-35-15-32-24-19(25(35)36)12-21(26(29,30)31)20(23(24)28)14-33-7-9-34(10-8-33)16(2)3/h5-6,11-12,15-16H,4,7-10,13-14H2,1-3H3
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n/an/a 33n/an/an/an/an/an/a



CHUGAI SEIYAKU KABUSHIKI KAISHA

US Patent


Assay Description
DDR1 binding activity was measured using the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporati...


US Patent US10005739 (2018)

More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM401186
PNG
(8-Chloro-3-[(5-chloro-2-ethylsulfonylphenyl)methyl...)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1Cn1cnc2c(Cl)c(CN3CC[C@@H](CN(C)C)C3)c(cc2c1=O)C(F)(F)F
Show InChI InChI=1S/C26H29Cl2F3N4O3S/c1-4-39(37,38)22-6-5-18(27)9-17(22)13-35-15-32-24-19(25(35)36)10-21(26(29,30)31)20(23(24)28)14-34-8-7-16(12-34)11-33(2)3/h5-6,9-10,15-16H,4,7-8,11-14H2,1-3H3/t16-/m0/s1
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CHUGAI SEIYAKU KABUSHIKI KAISHA

US Patent


Assay Description
DDR1 binding activity was measured using the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporati...


US Patent US10005739 (2018)

More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM401179
PNG
(8-Chloro-3-[(5-chloro-2-ethylsulfonylphenyl)methyl...)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1Cn1cnc2c(Cl)c(CN3CC[C@H](C3)N(C)C)c(cc2c1=O)C(F)(F)F
Show InChI InChI=1S/C25H27Cl2F3N4O3S/c1-4-38(36,37)21-6-5-16(26)9-15(21)11-34-14-31-23-18(24(34)35)10-20(25(28,29)30)19(22(23)27)13-33-8-7-17(12-33)32(2)3/h5-6,9-10,14,17H,4,7-8,11-13H2,1-3H3/t17-/m1/s1
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CHUGAI SEIYAKU KABUSHIKI KAISHA

US Patent


Assay Description
DDR1 binding activity was measured using the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporati...


US Patent US10005739 (2018)

More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM401140
PNG
(3-[(5-Chloro-2-ethylsulfonylphenyl)methyl]-7-(pipe...)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1Cn1cnc2cc(CN3CCNCC3)c(cc2c1=O)C(F)(F)F
Show InChI InChI=1S/C23H24ClF3N4O3S/c1-2-35(33,34)21-4-3-17(24)9-16(21)13-31-14-29-20-10-15(12-30-7-5-28-6-8-30)19(23(25,26)27)11-18(20)22(31)32/h3-4,9-11,14,28H,2,5-8,12-13H2,1H3
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CHUGAI SEIYAKU KABUSHIKI KAISHA

US Patent


Assay Description
DDR1 binding activity was measured using the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporati...


US Patent US10005739 (2018)

More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM400983
PNG
(6-Bromo-3-(5-chloro-2-ethylsulfonylanilino)-7-[(4-...)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1Nn1cnc2cc(CN3CCN(C)CC3)c(Br)cc2c1=O
Show InChI InChI=1S/C22H25BrClN5O3S/c1-3-33(31,32)21-5-4-16(24)11-20(21)26-29-14-25-19-10-15(18(23)12-17(19)22(29)30)13-28-8-6-27(2)7-9-28/h4-5,10-12,14,26H,3,6-9,13H2,1-2H3
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CHUGAI SEIYAKU KABUSHIKI KAISHA

US Patent


Assay Description
DDR1 binding activity was measured using the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporati...


US Patent US10005739 (2018)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%