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Patent code US10005756

Compile Data Set for Download or QSAR
Found 77 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401275
PNG
(US10005756, Compound A40)
Show SMILES NCCCNC(=O)c1cc2cc(ccc2[nH]1)N1CC[C@](O)(C(=O)NCc2cc(F)cc(Cl)c2)C1=O
Show InChI InChI=1/C24H25ClFN5O4/c25-16-8-14(9-17(26)12-16)13-29-22(33)24(35)4-7-31(23(24)34)18-2-3-19-15(10-18)11-20(30-19)21(32)28-6-1-5-27/h2-3,8-12,30,35H,1,4-7,13,27H2,(H,28,32)(H,29,33)/t24-/s2
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Merck Patent GmbH

US Patent


Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401283
PNG
(US10005756, Compound A50)
Show SMILES NCCCNC(=O)[C@H](CCC(N)=O)NC(=O)c1cc2cc(ccc2[nH]1)N1CC[C@](O)(C(=O)NCc2cc(F)cc(Cl)c2)C1=O
Show InChI InChI=1/C29H33ClFN7O6/c30-18-10-16(11-19(31)14-18)15-35-27(42)29(44)6-9-38(28(29)43)20-2-3-21-17(12-20)13-23(36-21)26(41)37-22(4-5-24(33)39)25(40)34-8-1-7-32/h2-3,10-14,22,36,44H,1,4-9,15,32H2,(H2,33,39)(H,34,40)(H,35,42)(H,37,41)/t22-,29-/s2
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US Patent


Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401272
PNG
(US10005756, Compound A35)
Show SMILES NCCCCNC(=O)c1cc2cc(ccc2[nH]1)N1CC[C@](O)(C(=O)NCc2cc(F)cc(Cl)c2)C1=O
Show InChI InChI=1/C25H27ClFN5O4/c26-17-9-15(10-18(27)13-17)14-30-23(34)25(36)5-8-32(24(25)35)19-3-4-20-16(11-19)12-21(31-20)22(33)29-7-2-1-6-28/h3-4,9-13,31,36H,1-2,5-8,14,28H2,(H,29,33)(H,30,34)/t25-/s2
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Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401245
PNG
(US10005756, Compound A6)
Show SMILES N\C(=N/O)c1cc2cc(ccc2[nH]1)N1CC[C@](O)(C(=O)NCc2cc(F)cc(Cl)c2)C1=O
Show InChI InChI=1/C21H19ClFN5O4/c22-13-5-11(6-14(23)9-13)10-25-19(29)21(31)3-4-28(20(21)30)15-1-2-16-12(7-15)8-17(26-16)18(24)27-32/h1-2,5-9,26,31-32H,3-4,10H2,(H2,24,27)(H,25,29)/t21-/s2
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Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401314
PNG
(US10005756, Compound A86)
Show SMILES NC(=O)c1cc2cc(ccc2[nH]1)N1CC[C@@](O)(C(=O)NCc2cc(F)cc(F)c2)C1=O
Show InChI InChI=1/C21H18F2N4O4/c22-13-5-11(6-14(23)9-13)10-25-19(29)21(31)3-4-27(20(21)30)15-1-2-16-12(7-15)8-17(26-16)18(24)28/h1-2,5-9,26,31H,3-4,10H2,(H2,24,28)(H,25,29)/t21-/s2
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Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401248
PNG
(US10005756, Compound A9)
Show SMILES O[C@@]1(CCN(C1=O)c1ccc2[nH]c(cc2c1)-c1nnco1)C(=O)NCc1cc(F)cc(Cl)c1
Show InChI InChI=1/C22H17ClFN5O4/c23-14-5-12(6-15(24)9-14)10-25-20(30)22(32)3-4-29(21(22)31)16-1-2-17-13(7-16)8-18(27-17)19-28-26-11-33-19/h1-2,5-9,11,27,32H,3-4,10H2,(H,25,30)/t22-/s2
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Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401270
PNG
(US10005756, Compound A33)
Show SMILES O[C@@]1(CCN(C1=O)c1cnc2[nH]cc(Br)c2c1)C(=O)NCc1cc(F)cc(Cl)c1
Show InChI InChI=1/C19H15BrClFN4O3/c20-15-9-24-16-14(15)6-13(8-23-16)26-2-1-19(29,18(26)28)17(27)25-7-10-3-11(21)5-12(22)4-10/h3-6,8-9,29H,1-2,7H2,(H,23,24)(H,25,27)/t19-/s2
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Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401267
PNG
(US10005756, Compound A30)
Show SMILES OC1(CCN(C1=O)c1ccc(cc1)S(=O)(=O)Nc1nccs1)C(=O)NCc1cc(F)cc(Cl)c1
Show InChI InChI=1S/C21H18ClFN4O5S2/c22-14-9-13(10-15(23)11-14)12-25-18(28)21(30)5-7-27(19(21)29)16-1-3-17(4-2-16)34(31,32)26-20-24-6-8-33-20/h1-4,6,8-11,30H,5,7,12H2,(H,24,26)(H,25,28)
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Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401315
PNG
(US10005756, Compound A87)
Show SMILES O[C@H]1CN(C(=O)[C@]1(O)C(=O)NCc1cc(F)cc(Cl)c1)c1ccccc1
Show InChI InChI=1S/C18H16ClFN2O4/c19-12-6-11(7-13(20)8-12)9-21-16(24)18(26)15(23)10-22(17(18)25)14-4-2-1-3-5-14/h1-8,15,23,26H,9-10H2,(H,21,24)/t15-,18+/m0/s1
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Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401301
PNG
(US10005756, Compound A72)
Show SMILES O[C@@]1(CCN(C1=O)c1ccc2[nH]c(cc2c1)C(=O)NCCCCNC(=O)CCCCC1SC[C@@H]2NC(=O)N[C@H]12)C(=O)NCc1cc(F)cc(Cl)c1
Show InChI InChI=1/C35H41ClFN7O6S/c36-22-13-20(14-23(37)17-22)18-40-32(47)35(50)9-12-44(33(35)48)24-7-8-25-21(15-24)16-26(41-25)31(46)39-11-4-3-10-38-29(45)6-2-1-5-28-30-27(19-51-28)42-34(49)43-30/h7-8,13-17,27-28,30,41,50H,1-6,9-12,18-19H2,(H,38,45)(H,39,46)(H,40,47)(H2,42,43,49)/t27-,28?,30-,35-/s2
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Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401297
PNG
(US10005756, Compound A68)
Show SMILES O[C@@]1(CCN(C1=O)c1ccc2[nH]c(cc2c1)C(=O)NCCCCNC=O)C(=O)NCc1cc(F)cc(Cl)c1
Show InChI InChI=1/C26H27ClFN5O5/c27-18-9-16(10-19(28)13-18)14-31-24(36)26(38)5-8-33(25(26)37)20-3-4-21-17(11-20)12-22(32-21)23(35)30-7-2-1-6-29-15-34/h3-4,9-13,15,32,38H,1-2,5-8,14H2,(H,29,34)(H,30,35)(H,31,36)/t26-/s2
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Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401271
PNG
(US10005756, Compound A34)
Show SMILES O[C@@]1(CCN(C1=O)c1cnc2[nH]cc(I)c2c1)C(=O)NCc1cc(F)cc(Cl)c1
Show InChI InChI=1/C19H15ClFIN4O3/c20-11-3-10(4-12(21)5-11)7-25-17(27)19(29)1-2-26(18(19)28)13-6-14-15(22)9-24-16(14)23-8-13/h3-6,8-9,29H,1-2,7H2,(H,23,24)(H,25,27)/t19-/s2
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Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401247
PNG
(US10005756, Compound A8)
Show SMILES Cc1nnc(o1)-c1cc2cc(ccc2[nH]1)N1CC[C@](O)(C(=O)NCc2cc(F)cc(Cl)c2)C1=O
Show InChI InChI=1/C23H19ClFN5O4/c1-12-28-29-20(34-12)19-9-14-8-17(2-3-18(14)27-19)30-5-4-23(33,22(30)32)21(31)26-11-13-6-15(24)10-16(25)7-13/h2-3,6-10,27,33H,4-5,11H2,1H3,(H,26,31)/t23-/s2
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Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401274
PNG
(US10005756, Compound A39)
Show SMILES NC(=O)CC[C@H](NC(=O)c1cc2cc(ccc2[nH]1)N1CC[C@](O)(C(=O)NCc2cc(F)cc(Cl)c2)C1=O)C(O)=O
Show InChI InChI=1/C26H25ClFN5O7/c27-15-7-13(8-16(28)11-15)12-30-24(38)26(40)5-6-33(25(26)39)17-1-2-18-14(9-17)10-20(31-18)22(35)32-19(23(36)37)3-4-21(29)34/h1-2,7-11,19,31,40H,3-6,12H2,(H2,29,34)(H,30,38)(H,32,35)(H,36,37)/t19-,26-/s2
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Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401285
PNG
(US10005756, Compound A52)
Show SMILES NC(=O)CC[C@H](NC(=O)c1cc2cc(ccc2[nH]1)N1CC[C@](O)(C(=O)NCc2cc(F)cc(Cl)c2)C1=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1/C35H35ClFN7O7/c36-22-12-20(13-23(37)17-22)18-40-33(49)35(51)10-11-44(34(35)50)24-6-7-25-21(15-24)16-28(41-25)32(48)42-26(8-9-29(38)45)31(47)43-27(30(39)46)14-19-4-2-1-3-5-19/h1-7,12-13,15-17,26-27,41,51H,8-11,14,18H2,(H2,38,45)(H2,39,46)(H,40,49)(H,42,48)(H,43,47)/t26-,27-,35-/s2
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Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401249
PNG
(US10005756, Compound A10)
Show SMILES O[C@@]1(CCN(C1=O)c1ccc2[nH]c(cc2c1)-c1nnn[nH]1)C(=O)NCc1cc(F)cc(Cl)c1
Show InChI InChI=1S/C21H15ClFN7O3/c22-13-5-11(6-14(23)9-13)10-24-19(31)21(33)3-4-30(20(21)32)15-1-2-16-12(7-15)8-17(25-16)18-26-28-29-27-18/h1-2,5-9,33H,3-4,10H2,(H,24,31)/t21-/m0/s1
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Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401284
PNG
(US10005756, Compound A51)
Show SMILES CN(C)C(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)c1cc2cc(ccc2[nH]1)N1CC[C@](O)(C(=O)NCc2cc(F)cc(Cl)c2)C1=O
Show InChI InChI=1/C30H33ClFN7O7/c1-38(2)25(41)15-34-26(42)22(5-6-24(33)40)37-27(43)23-12-17-11-20(3-4-21(17)36-23)39-8-7-30(46,29(39)45)28(44)35-14-16-9-18(31)13-19(32)10-16/h3-4,9-13,22,36,46H,5-8,14-15H2,1-2H3,(H2,33,40)(H,34,42)(H,35,44)(H,37,43)/t22-,30-/s2
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Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401250
PNG
(US10005756, Compound A11)
Show SMILES Cc1nc(no1)-c1cc2cc(ccc2[nH]1)N1CC[C@](O)(C(=O)NCc2cc(F)cc(Cl)c2)C1=O
Show InChI InChI=1/C23H19ClFN5O4/c1-12-27-20(29-34-12)19-9-14-8-17(2-3-18(14)28-19)30-5-4-23(33,22(30)32)21(31)26-11-13-6-15(24)10-16(25)7-13/h2-3,6-10,28,33H,4-5,11H2,1H3,(H,26,31)/t23-/s2
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Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401299
PNG
(US10005756, Compound A70)
Show SMILES C[S@](=N)(=O)c1ccc(cc1)N1CC[C@](O)(C(=O)NCc2cc(F)cc(Cl)c2)C1=O
Show InChI InChI=1S/C19H19ClFN3O4S/c1-29(22,28)16-4-2-15(3-5-16)24-7-6-19(27,18(24)26)17(25)23-11-12-8-13(20)10-14(21)9-12/h2-5,8-10,22,27H,6-7,11H2,1H3,(H,23,25)/t19-,29-/m0/s1
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US Patent


Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401264
PNG
(US10005756, Compound A27)
Show SMILES CC(C)(C)OC(=O)C(CCC(N)=O)NC(=O)c1cc2cc(ccc2[nH]1)N1CC[C@](O)(C(=O)NCc2cc(F)cc(Cl)c2)C1=O
Show InChI InChI=1/C30H33ClFN5O7/c1-29(2,3)44-26(40)22(6-7-24(33)38)36-25(39)23-13-17-12-20(4-5-21(17)35-23)37-9-8-30(43,28(37)42)27(41)34-15-16-10-18(31)14-19(32)11-16/h4-5,10-14,22,35,43H,6-9,15H2,1-3H3,(H2,33,38)(H,34,41)(H,36,39)/t22?,30-/s2
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US Patent


Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401307
PNG
(US10005756, Compound A78)
Show SMILES O[C@@]1(CCN(C1=O)c1cnc2[nH]ccc2c1)C(=O)NCc1cc(F)cc(F)c1
Show InChI InChI=1/C19H16F2N4O3/c20-13-5-11(6-14(21)8-13)9-24-17(26)19(28)2-4-25(18(19)27)15-7-12-1-3-22-16(12)23-10-15/h1,3,5-8,10,28H,2,4,9H2,(H,22,23)(H,24,26)/t19-/s2
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US Patent


Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401304
PNG
(US10005756, Compound A75)
Show SMILES O[C@@]1(CCN(C1=O)c1ccc2[nH]ncc2c1)C(=O)NCc1cc(F)cc(F)c1
Show InChI InChI=1/C19H16F2N4O3/c20-13-5-11(6-14(21)8-13)9-22-17(26)19(28)3-4-25(18(19)27)15-1-2-16-12(7-15)10-23-24-16/h1-2,5-8,10,28H,3-4,9H2,(H,22,26)(H,23,24)/t19-/s2
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US Patent


Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401244
PNG
(US10005756, Compound A5)
Show SMILES CCNS(=O)(=O)c1ccc(cc1)N1CC[C@](O)(C(=O)NCc2cc(F)cc(Cl)c2)C1=O
Show InChI InChI=1S/C20H21ClFN3O5S/c1-2-24-31(29,30)17-5-3-16(4-6-17)25-8-7-20(28,19(25)27)18(26)23-12-13-9-14(21)11-15(22)10-13/h3-6,9-11,24,28H,2,7-8,12H2,1H3,(H,23,26)/t20-/m0/s1
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US Patent


Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401296
PNG
(US10005756, Compound A67)
Show SMILES O[C@@]1(CCN(C1=O)c1cccc(OC(F)(F)F)c1)C(=O)NCc1cc(F)cc(Cl)c1
Show InChI InChI=1S/C19H15ClF4N2O4/c20-12-6-11(7-13(21)8-12)10-25-16(27)18(29)4-5-26(17(18)28)14-2-1-3-15(9-14)30-19(22,23)24/h1-3,6-9,29H,4-5,10H2,(H,25,27)/t18-/m0/s1
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US Patent


Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401295
PNG
(US10005756, Compound A66)
Show SMILES O[C@@]1(CCN(C1=O)c1ccc2NC(=O)Cc2c1)C(=O)NCc1cc(F)cc(F)c1
Show InChI InChI=1S/C20H17F2N3O4/c21-13-5-11(6-14(22)9-13)10-23-18(27)20(29)3-4-25(19(20)28)15-1-2-16-12(7-15)8-17(26)24-16/h1-2,5-7,9,29H,3-4,8,10H2,(H,23,27)(H,24,26)/t20-/m0/s1
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US Patent


Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401286
PNG
(US10005756, Compound A53)
Show SMILES O[C@@]1(CCN(C1=O)c1cnc2[nH]cc(F)c2c1)C(=O)NCc1cc(F)cc(Cl)c1
Show InChI InChI=1/C19H15ClF2N4O3/c20-11-3-10(4-12(21)5-11)7-25-17(27)19(29)1-2-26(18(19)28)13-6-14-15(22)9-24-16(14)23-8-13/h3-6,8-9,29H,1-2,7H2,(H,23,24)(H,25,27)/t19-/s2
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US Patent


Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401298
PNG
(US10005756, Compound A69)
Show SMILES C[S@@](=N)(=O)c1ccc(cc1)N1CC[C@](O)(C(=O)NCc2cc(F)cc(Cl)c2)C1=O
Show InChI InChI=1S/C19H19ClFN3O4S/c1-29(22,28)16-4-2-15(3-5-16)24-7-6-19(27,18(24)26)17(25)23-11-12-8-13(20)10-14(21)9-12/h2-5,8-10,22,27H,6-7,11H2,1H3,(H,23,25)/t19-,29+/m0/s1
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Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401316
PNG
(US10005756, Compound A89)
Show SMILES O[C@@]1(CCN(C1=O)c1cnc2[nH]cc(F)c2c1)C(=O)NCc1cc(F)cc(F)c1
Show InChI InChI=1/C19H15F3N4O3/c20-11-3-10(4-12(21)5-11)7-25-17(27)19(29)1-2-26(18(19)28)13-6-14-15(22)9-24-16(14)23-8-13/h3-6,8-9,29H,1-2,7H2,(H,23,24)(H,25,27)/t19-/s2
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Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401303
PNG
(US10005756, Compound A74)
Show SMILES OB1OCCc2cc(ccc12)N1CCC(O)(C(=O)NCc2cc(F)cc(Cl)c2)C1=O
Show InChI InChI=1S/C20H19BClFN2O5/c22-14-7-12(8-15(23)10-14)11-24-18(26)20(28)4-5-25(19(20)27)16-1-2-17-13(9-16)3-6-30-21(17)29/h1-2,7-10,28-29H,3-6,11H2,(H,24,26)
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US Patent


Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401294
PNG
(US10005756, Compound A65)
Show SMILES O[C@@]1(CCN(C1=O)c1ccc(OC(F)(F)F)cc1)C(=O)NCc1cc(F)cc(Cl)c1
Show InChI InChI=1S/C19H15ClF4N2O4/c20-12-7-11(8-13(21)9-12)10-25-16(27)18(29)5-6-26(17(18)28)14-1-3-15(4-2-14)30-19(22,23)24/h1-4,7-9,29H,5-6,10H2,(H,25,27)/t18-/m0/s1
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Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401289
PNG
(US10005756, Compound A60)
Show SMILES OC1(CCN(C1=O)c1ccc(cc1)C(F)F)C(=O)NCc1cc(F)cc(Cl)c1
Show InChI InChI=1S/C19H16ClF3N2O3/c20-13-7-11(8-14(21)9-13)10-24-17(26)19(28)5-6-25(18(19)27)15-3-1-12(2-4-15)16(22)23/h1-4,7-9,16,28H,5-6,10H2,(H,24,26)
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Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401240
PNG
(US10005756, Compound A1)
Show SMILES O[C@@]1(CCN(C1=O)c1cccc(c1)[N](=O)(=O)N1CCNCC1)C(=O)NCc1cc(F)cc(Cl)c1
Show InChI InChI=1S/C22H24ClFN5O5/c23-16-10-15(11-17(24)12-16)14-26-20(30)22(32)4-7-28(21(22)31)18-2-1-3-19(13-18)29(33,34)27-8-5-25-6-9-27/h1-3,10-13,25,32H,4-9,14H2,(H,26,30)/t22-/m0/s1
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Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401265
PNG
(US10005756, Compound A28)
Show SMILES OC1(CCN(C1=O)c1ccc2CS(=O)(=O)Cc2c1)C(=O)NCc1cc(F)cc(Cl)c1
Show InChI InChI=1S/C20H18ClFN2O5S/c21-15-5-12(6-16(22)8-15)9-23-18(25)20(27)3-4-24(19(20)26)17-2-1-13-10-30(28,29)11-14(13)7-17/h1-2,5-8,27H,3-4,9-11H2,(H,23,25)
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US Patent


Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401251
PNG
(US10005756, Compound A13)
Show SMILES OC1CN(C(=O)C1(O)C(=O)NCc1cc(F)cc(Cl)c1)c1ccccc1
Show InChI InChI=1S/C18H16ClFN2O4/c19-12-6-11(7-13(20)8-12)9-21-16(24)18(26)15(23)10-22(17(18)25)14-4-2-1-3-5-14/h1-8,15,23,26H,9-10H2,(H,21,24)
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US Patent


Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401259
PNG
(US10005756, Compound A22)
Show SMILES OC1(CCN(C1=O)c1ccc2[nH]c(Br)cc2c1)C(=O)NCc1cc(F)cc(Cl)c1
Show InChI InChI=1/C20H16BrClFN3O3/c21-17-8-12-7-15(1-2-16(12)25-17)26-4-3-20(29,19(26)28)18(27)24-10-11-5-13(22)9-14(23)6-11/h1-2,5-9,25,29H,3-4,10H2,(H,24,27)
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Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401308
PNG
(US10005756, Compound A79)
Show SMILES O[C@@]1(CCN(C1=O)c1cnc2[nH]cc(Cl)c2c1)C(=O)NCc1cc(F)cc(F)c1
Show InChI InChI=1/C19H15ClF2N4O3/c20-15-9-24-16-14(15)6-13(8-23-16)26-2-1-19(29,18(26)28)17(27)25-7-10-3-11(21)5-12(22)4-10/h3-6,8-9,29H,1-2,7H2,(H,23,24)(H,25,27)/t19-/s2
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Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401305
PNG
(US10005756, Compound A76)
Show SMILES COc1ccc(Cn2ccc3cc(cnc23)N2CC[C@](O)(C(=O)NCc3cc(F)cc(F)c3)C2=O)cc1
Show InChI InChI=1S/C27H24F2N4O4/c1-37-23-4-2-17(3-5-23)16-32-8-6-19-12-22(15-30-24(19)32)33-9-7-27(36,26(33)35)25(34)31-14-18-10-20(28)13-21(29)11-18/h2-6,8,10-13,15,36H,7,9,14,16H2,1H3,(H,31,34)/t27-/m0/s1
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Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401288
PNG
(US10005756, Compound A58)
Show SMILES O[C@@]1(CCN(C1=O)c1ccc2n(ccc2c1)S(=O)(=O)c1ccccc1)C(=O)NCc1cc(F)cc(F)c1
Show InChI InChI=1S/C26H21F2N3O5S/c27-19-12-17(13-20(28)15-19)16-29-24(32)26(34)9-11-30(25(26)33)21-6-7-23-18(14-21)8-10-31(23)37(35,36)22-4-2-1-3-5-22/h1-8,10,12-15,34H,9,11,16H2,(H,29,32)/t26-/m0/s1
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Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401309
PNG
(US10005756, Compound A80)
Show SMILES NC(=O)c1cccc(c1)N1CCC(O)(C(=O)NCc2cc(F)cc(Cl)c2)C1=O
Show InChI InChI=1S/C19H17ClFN3O4/c20-13-6-11(7-14(21)9-13)10-23-17(26)19(28)4-5-24(18(19)27)15-3-1-2-12(8-15)16(22)25/h1-3,6-9,28H,4-5,10H2,(H2,22,25)(H,23,26)
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Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401255
PNG
(US10005756, Compound A18)
Show SMILES Oc1cccc(c1)N1CCC(O)(C(=O)NCc2cc(F)cc(Cl)c2)C1=O
Show InChI InChI=1S/C18H16ClFN2O4/c19-12-6-11(7-13(20)8-12)10-21-16(24)18(26)4-5-22(17(18)25)14-2-1-3-15(23)9-14/h1-3,6-9,23,26H,4-5,10H2,(H,21,24)
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Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401312
PNG
(US10005756, Compound A83)
Show SMILES NC(=O)c1ccc2cc(ccc2n1)N1CCC(O)(C(=O)NCc2cc(F)cc(Cl)c2)C1=O
Show InChI InChI=1S/C22H18ClFN4O4/c23-14-7-12(8-15(24)10-14)11-26-20(30)22(32)5-6-28(21(22)31)16-2-4-17-13(9-16)1-3-18(27-17)19(25)29/h1-4,7-10,32H,5-6,11H2,(H2,25,29)(H,26,30)
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Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401242
PNG
(US10005756, Compound A3)
Show SMILES C[C@H](N1CC[C@](O)(C(=O)NCc2cc(F)cc(Cl)c2)C1=O)c1ccccc1
Show InChI InChI=1S/C20H20ClFN2O3/c1-13(15-5-3-2-4-6-15)24-8-7-20(27,19(24)26)18(25)23-12-14-9-16(21)11-17(22)10-14/h2-6,9-11,13,27H,7-8,12H2,1H3,(H,23,25)/t13-,20-/m0/s1
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Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401266
PNG
(US10005756, Compound A29)
Show SMILES OC(c1ccc(cc1)N1CCC(O)(C(=O)NCc2cc(F)cc(Cl)c2)C1=O)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C21H16ClF7N2O4/c22-13-7-11(8-14(23)9-13)10-30-16(32)18(34)5-6-31(17(18)33)15-3-1-12(2-4-15)19(35,20(24,25)26)21(27,28)29/h1-4,7-9,34-35H,5-6,10H2,(H,30,32)
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Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401254
PNG
(US10005756, Compound A17)
Show SMILES CC(=O)Nc1cc2cc(ccc2oc1=O)N1CCC(O)(C(=O)NCc2cc(F)cc(Cl)c2)C1=O
Show InChI InChI=1S/C23H19ClFN3O6/c1-12(29)27-18-9-14-8-17(2-3-19(14)34-20(18)30)28-5-4-23(33,22(28)32)21(31)26-11-13-6-15(24)10-16(25)7-13/h2-3,6-10,33H,4-5,11H2,1H3,(H,26,31)(H,27,29)
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Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401273
PNG
(US10005756, Compound A38)
Show SMILES ON(c1ccccn1)S(=O)(=O)c1ccc(cc1)N1CCC(O)(C(=O)NCc2cc(F)cc(Cl)c2)C1=O
Show InChI InChI=1S/C23H20ClFN4O6S/c24-16-11-15(12-17(25)13-16)14-27-21(30)23(32)8-10-28(22(23)31)18-4-6-19(7-5-18)36(34,35)29(33)20-3-1-2-9-26-20/h1-7,9,11-13,32-33H,8,10,14H2,(H,27,30)
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Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401258
PNG
(US10005756, Compound A21)
Show SMILES OCC(N1CCC(O)(C(=O)NCc2cc(F)cc(Cl)c2)C1=O)c1ccccc1
Show InChI InChI=1S/C20H20ClFN2O4/c21-15-8-13(9-16(22)10-15)11-23-18(26)20(28)6-7-24(19(20)27)17(12-25)14-4-2-1-3-5-14/h1-5,8-10,17,25,28H,6-7,11-12H2,(H,23,26)
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Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401276
PNG
(US10005756, Compound A41)
Show SMILES OB1OCc2cc(ccc12)N1CC[C@](O)(C(=O)NCc2cc(F)cc(Cl)c2)C1=O
Show InChI InChI=1S/C19H17BClFN2O5/c21-13-5-11(6-14(22)8-13)9-23-17(25)19(27)3-4-24(18(19)26)15-1-2-16-12(7-15)10-29-20(16)28/h1-2,5-8,27-28H,3-4,9-10H2,(H,23,25)/t19-/m0/s1
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Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401279
PNG
(US10005756, Compound A44 | US10005756, Compound A4...)
Show SMILES CC(C)C(NC(=O)CN1CCC(O)(C(=O)NCc2cc(F)cc(Cl)c2)C1=O)C(=O)N(C)C
Show InChI InChI=1S/C21H28ClFN4O5/c1-12(2)17(18(29)26(3)4)25-16(28)11-27-6-5-21(32,20(27)31)19(30)24-10-13-7-14(22)9-15(23)8-13/h7-9,12,17,32H,5-6,10-11H2,1-4H3,(H,24,30)(H,25,28)
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Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401310
PNG
(US10005756, Compound A81)
Show SMILES C[S@](=N)(=O)c1cccc(c1)N1CC[C@](O)(C(=O)NCc2cc(F)cc(Cl)c2)C1=O
Show InChI InChI=1S/C19H19ClFN3O4S/c1-29(22,28)16-4-2-3-15(10-16)24-6-5-19(27,18(24)26)17(25)23-11-12-7-13(20)9-14(21)8-12/h2-4,7-10,22,27H,5-6,11H2,1H3,(H,23,25)/t19-,29-/m0/s1
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Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401281
PNG
(US10005756, Compound A47)
Show SMILES OC1(CCN(C1=O)c1ccc2NC(Cc2c1)C1CC1)C(=O)NCc1cc(F)cc(Cl)c1
Show InChI InChI=1S/C23H23ClFN3O3/c24-16-7-13(8-17(25)11-16)12-26-21(29)23(31)5-6-28(22(23)30)18-3-4-19-15(9-18)10-20(27-19)14-1-2-14/h3-4,7-9,11,14,20,27,31H,1-2,5-6,10,12H2,(H,26,29)
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Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401277
PNG
(US10005756, Compound A42)
Show SMILES OC1(CCN(C1=O)c1ccc2NS(=O)(=O)Cc2c1)C(=O)NCc1cc(F)cc(Cl)c1
Show InChI InChI=1S/C19H17ClFN3O5S/c20-13-5-11(6-14(21)8-13)9-22-17(25)19(27)3-4-24(18(19)26)15-1-2-16-12(7-15)10-30(28,29)23-16/h1-2,5-8,23,27H,3-4,9-10H2,(H,22,25)
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Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401311
PNG
(US10005756, Compound A82)
Show SMILES C[S@@](=N)(=O)c1cccc(c1)N1CC[C@](O)(C(=O)NCc2cc(F)cc(Cl)c2)C1=O
Show InChI InChI=1S/C19H19ClFN3O4S/c1-29(22,28)16-4-2-3-15(10-16)24-6-5-19(27,18(24)26)17(25)23-11-12-7-13(20)9-14(21)8-12/h2-4,7-10,22,27H,5-6,11H2,1H3,(H,23,25)/t19-,29+/m0/s1
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Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401293
PNG
(US10005756, Compound A64)
Show SMILES CS(N)(=O)c1ccc(cc1)N1CCC(O)(C(=O)NCc2cc(F)cc(Cl)c2)C1=O
Show InChI InChI=1S/C19H21ClFN3O4S/c1-29(22,28)16-4-2-15(3-5-16)24-7-6-19(27,18(24)26)17(25)23-11-12-8-13(20)10-14(21)9-12/h2-5,8-10,27,29H,6-7,11H2,1H3,(H2,22,28)(H,23,25)
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Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401291
PNG
(US10005756, Compound A62)
Show SMILES O[C@@]1(CCN(C1=O)c1cnc2[nH]c(Cl)c(Cl)c2c1)C(=O)NCc1cc(F)cc(Cl)c1
Show InChI InChI=1/C19H14Cl3FN4O3/c20-10-3-9(4-11(23)5-10)7-25-17(28)19(30)1-2-27(18(19)29)12-6-13-14(21)15(22)26-16(13)24-8-12/h3-6,8,30H,1-2,7H2,(H,24,26)(H,25,28)/t19-/s2
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Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401253
PNG
(US10005756, Compound A16)
Show SMILES OC1(CCN(C1=O)c1ccc2oc(=O)ccc2c1)C(=O)NCc1cc(F)cc(Cl)c1
Show InChI InChI=1S/C21H16ClFN2O5/c22-14-7-12(8-15(23)10-14)11-24-19(27)21(29)5-6-25(20(21)28)16-2-3-17-13(9-16)1-4-18(26)30-17/h1-4,7-10,29H,5-6,11H2,(H,24,27)
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Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401262
PNG
(US10005756, Compound A25)
Show SMILES OC1(CCN(C1=O)c1ccc2[nH]c(nc2c1)-c1ccc(Cl)cc1)C(=O)NCc1cc(F)cc(Cl)c1
Show InChI InChI=1/C25H19Cl2FN4O3/c26-16-3-1-15(2-4-16)22-30-20-6-5-19(12-21(20)31-22)32-8-7-25(35,24(32)34)23(33)29-13-14-9-17(27)11-18(28)10-14/h1-6,9-12,35H,7-8,13H2,(H,29,33)(H,30,31)
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Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401287
PNG
(US10005756, Compound A55)
Show SMILES OC1(CCN(C1=O)c1ccc2n(ccc2c1)S(=O)(=O)c1ccccc1)C(=O)NCc1cc(F)cc(F)c1
Show InChI InChI=1S/C26H21F2N3O5S/c27-19-12-17(13-20(28)15-19)16-29-24(32)26(34)9-11-30(25(26)33)21-6-7-23-18(14-21)8-10-31(23)37(35,36)22-4-2-1-3-5-22/h1-8,10,12-15,34H,9,11,16H2,(H,29,32)
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Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401252
PNG
(US10005756, Compound A15)
Show SMILES OC1(CCN(C1=O)c1ccn[nH]1)C(=O)NCc1cc(F)cc(Cl)c1
Show InChI InChI=1/C15H14ClFN4O3/c16-10-5-9(6-11(17)7-10)8-18-13(22)15(24)2-4-21(14(15)23)12-1-3-19-20-12/h1,3,5-7,24H,2,4,8H2,(H,18,22)(H,19,20)
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Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401292
PNG
(US10005756, Compound A63)
Show SMILES O[C@@]1(CCN(C1=O)c1cnc(C(F)F)c(Cl)c1)C(=O)NCc1cc(F)cc(Cl)c1
Show InChI InChI=1S/C18H14Cl2F3N3O3/c19-10-3-9(4-11(21)5-10)7-25-16(27)18(29)1-2-26(17(18)28)12-6-13(20)14(15(22)23)24-8-12/h3-6,8,15,29H,1-2,7H2,(H,25,27)/t18-/m0/s1
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Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401246
PNG
(US10005756, Compound A7)
Show SMILES OC1(CCN(C1=O)c1cccc(c1)-c1nnn[nH]1)C(=O)NCc1cc(F)cc(Cl)c1
Show InChI InChI=1/C19H16ClFN6O3/c20-13-6-11(7-14(21)9-13)10-22-17(28)19(30)4-5-27(18(19)29)15-3-1-2-12(8-15)16-23-25-26-24-16/h1-3,6-9,30H,4-5,10H2,(H,22,28)(H,23,24,25,26)
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Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401290
PNG
(US10005756, Compound A61)
Show SMILES OC1(CCN(C1=O)c1ccc(nc1)C(F)F)C(=O)NCc1cc(F)cc(Cl)c1
Show InChI InChI=1S/C18H15ClF3N3O3/c19-11-5-10(6-12(20)7-11)8-24-16(26)18(28)3-4-25(17(18)27)13-1-2-14(15(21)22)23-9-13/h1-2,5-7,9,15,28H,3-4,8H2,(H,24,26)
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n/an/a 490n/an/an/an/an/an/a



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US Patent


Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401263
PNG
(US10005756, Compound A26)
Show SMILES O[C@@]1(CCN(C1=O)c1cncnc1)C(=O)NCc1cc(F)cc(Cl)c1
Show InChI InChI=1S/C16H14ClFN4O3/c17-11-3-10(4-12(18)5-11)6-21-14(23)16(25)1-2-22(15(16)24)13-7-19-9-20-8-13/h3-5,7-9,25H,1-2,6H2,(H,21,23)/t16-/m0/s1
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n/an/a 500n/an/an/an/an/an/a



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US Patent


Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401243
PNG
(US10005756, Compound A4)
Show SMILES O[C@@]1(CCN(C1=O)c1cnc(Cl)c(F)c1)C(=O)NCc1cc(F)cc(Cl)c1
Show InChI InChI=1S/C17H13Cl2F2N3O3/c18-10-3-9(4-11(20)5-10)7-23-15(25)17(27)1-2-24(16(17)26)12-6-13(21)14(19)22-8-12/h3-6,8,27H,1-2,7H2,(H,23,25)/t17-/m0/s1
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n/an/a 520n/an/an/an/an/an/a



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US Patent


Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401300
PNG
(US10005756, Compound A71)
Show SMILES CS(N)(=O)c1cccc(c1)N1CCC(O)(C(=O)NCc2cc(F)cc(Cl)c2)C1=O
Show InChI InChI=1S/C19H21ClFN3O4S/c1-29(22,28)16-4-2-3-15(10-16)24-6-5-19(27,18(24)26)17(25)23-11-12-7-13(20)9-14(21)8-12/h2-4,7-10,27,29H,5-6,11H2,1H3,(H2,22,28)(H,23,25)
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Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401306
PNG
(US10005756, Compound A77)
Show SMILES O[C@]1(CCNC1=O)C(=O)NCc1cc(F)cc(F)c1
Show InChI InChI=1S/C12H12F2N2O3/c13-8-3-7(4-9(14)5-8)6-16-11(18)12(19)1-2-15-10(12)17/h3-5,19H,1-2,6H2,(H,15,17)(H,16,18)/t12-/m0/s1
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n/an/a 790n/an/an/an/an/an/a



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US Patent


Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401241
PNG
(US10005756, Compound A2)
Show SMILES C[C@@H](N1CC[C@](O)(C(=O)NCc2cc(F)cc(Cl)c2)C1=O)c1ccccc1
Show InChI InChI=1S/C20H20ClFN2O3/c1-13(15-5-3-2-4-6-15)24-8-7-20(27,19(24)26)18(25)23-12-14-9-16(21)11-17(22)10-14/h2-6,9-11,13,27H,7-8,12H2,1H3,(H,23,25)/t13-,20+/m1/s1
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n/an/a 810n/an/an/an/an/an/a



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US Patent


Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401278
PNG
(US10005756, Compound A43)
Show SMILES COc1ccc(CN2c3ccc(cc3CS2(=O)=O)N2CCC(O)(C(=O)NCc3cc(F)cc(Cl)c3)C2=O)cc1
Show InChI InChI=1S/C27H25ClFN3O6S/c1-38-23-5-2-17(3-6-23)15-32-24-7-4-22(12-19(24)16-39(32,36)37)31-9-8-27(35,26(31)34)25(33)30-14-18-10-20(28)13-21(29)11-18/h2-7,10-13,35H,8-9,14-16H2,1H3,(H,30,33)
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n/an/a 840n/an/an/an/an/an/a



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US Patent


Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401257
PNG
(US10005756, Compound A20)
Show SMILES CC[C@@H](N1CC[C@](O)(C(=O)NCc2cc(F)cc(Cl)c2)C1=O)c1ccccc1
Show InChI InChI=1S/C21H22ClFN2O3/c1-2-18(15-6-4-3-5-7-15)25-9-8-21(28,20(25)27)19(26)24-13-14-10-16(22)12-17(23)11-14/h3-7,10-12,18,28H,2,8-9,13H2,1H3,(H,24,26)/t18-,21+/m1/s1
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n/an/a 1.00E+3n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401302
PNG
(US10005756, Compound A73)
Show SMILES OC1(CCNC1=O)C(=O)NCc1cc(F)cc(F)c1
Show InChI InChI=1S/C12H12F2N2O3/c13-8-3-7(4-9(14)5-8)6-16-11(18)12(19)1-2-15-10(12)17/h3-5,19H,1-2,6H2,(H,15,17)(H,16,18)
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n/an/a 2.30E+3n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401313
PNG
(US10005756, Compound A85)
Show SMILES CCOC(=O)c1cc2cc(ccc2[nH]1)N1CC[C@](O)(C(=O)NCc2cc(F)cc(F)c2)C1=O
Show InChI InChI=1/C23H21F2N3O5/c1-2-33-20(29)19-10-14-9-17(3-4-18(14)27-19)28-6-5-23(32,22(28)31)21(30)26-12-13-7-15(24)11-16(25)8-13/h3-4,7-11,27,32H,2,5-6,12H2,1H3,(H,26,30)/t23-/s2
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n/an/a 2.80E+3n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401261
PNG
(US10005756, Compound A24)
Show SMILES CC[C@H](N1CC[C@](O)(C(=O)NCc2cc(F)cc(Cl)c2)C1=O)c1ccccc1
Show InChI InChI=1S/C21H22ClFN2O3/c1-2-18(15-6-4-3-5-7-15)25-9-8-21(28,20(25)27)19(26)24-13-14-10-16(22)12-17(23)11-14/h3-7,10-12,18,28H,2,8-9,13H2,1H3,(H,24,26)/t18-,21-/m0/s1
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n/an/a 3.50E+3n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401256
PNG
(US10005756, Compound A19)
Show SMILES Nc1ccc(cc1\C=C\C(O)=O)N1CCC(O)(C(=O)NCc2cc(F)cc(Cl)c2)C1=O
Show InChI InChI=1S/C21H19ClFN3O5/c22-14-7-12(8-15(23)10-14)11-25-19(29)21(31)5-6-26(20(21)30)16-2-3-17(24)13(9-16)1-4-18(27)28/h1-4,7-10,31H,5-6,11,24H2,(H,25,29)(H,27,28)/b4-1+
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n/an/a 4.60E+3n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401269
PNG
(US10005756, Compound A32)
Show SMILES O[C@]1(CCN(C1=O)c1cnc2[nH]cc(I)c2c1)C(=O)NCc1cc(F)cc(Cl)c1
Show InChI InChI=1/C19H15ClFIN4O3/c20-11-3-10(4-12(21)5-11)7-25-17(27)19(29)1-2-26(18(19)28)13-6-14-15(22)9-24-16(14)23-8-13/h3-6,8-9,29H,1-2,7H2,(H,23,24)(H,25,27)/t19-/s2
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n/an/a 5.20E+3n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401282
PNG
(US10005756, Compound A49)
Show SMILES O[C@]1(CCN(C1=O)c1ccc2[nH]c(cc2c1)C(F)(F)F)C(=O)NCc1cc(F)cc(Cl)c1
Show InChI InChI=1/C21H16ClF4N3O3/c22-13-5-11(6-14(23)9-13)10-27-18(30)20(32)3-4-29(19(20)31)15-1-2-16-12(7-15)8-17(28-16)21(24,25)26/h1-2,5-9,28,32H,3-4,10H2,(H,27,30)/t20-/s2
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n/an/a 5.50E+3n/an/an/an/an/an/a



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US Patent


Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401268
PNG
(US10005756, Compound A31)
Show SMILES O[C@]1(CCN(C1=O)c1cnc2[nH]cc(Br)c2c1)C(=O)NCc1cc(F)cc(Cl)c1
Show InChI InChI=1/C19H15BrClFN4O3/c20-15-9-24-16-14(15)6-13(8-23-16)26-2-1-19(29,18(26)28)17(27)25-7-10-3-11(21)5-12(22)4-10/h3-6,8-9,29H,1-2,7H2,(H,23,24)(H,25,27)/t19-/s2
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n/an/a 6.30E+3n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401260
PNG
(US10005756, Compound A23)
Show SMILES CC(C)[C@H](N1CC[C@@](O)(C(=O)NCc2cc(F)cc(Cl)c2)C1=O)c1ccccc1
Show InChI InChI=1S/C22H24ClFN2O3/c1-14(2)19(16-6-4-3-5-7-16)26-9-8-22(29,21(26)28)20(27)25-13-15-10-17(23)12-18(24)11-15/h3-7,10-12,14,19,29H,8-9,13H2,1-2H3,(H,25,27)/t19-,22+/m0/s1
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n/an/a 7.00E+3n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM401279
PNG
(US10005756, Compound A44 | US10005756, Compound A4...)
Show SMILES CC(C)C(NC(=O)CN1CCC(O)(C(=O)NCc2cc(F)cc(Cl)c2)C1=O)C(=O)N(C)C
Show InChI InChI=1S/C21H28ClFN4O5/c1-12(2)17(18(29)26(3)4)25-16(28)11-27-6-5-21(32,20(27)31)19(30)24-10-13-7-14(22)9-15(23)8-13/h7-9,12,17,32H,5-6,10-11H2,1-4H3,(H,24,30)(H,25,28)
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n/an/a 9.10E+3n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat...


US Patent US10005756 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%