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Patent code US10005762

Compile Data Set for Download or QSAR
Found 159 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401319
PNG
(US10005762, Example 3)
Show SMILES Cc1cnc(C[C@@](O)([C@@H](N)CCC2CC2)C(O)=O)cc1CCCC1CC1
Show InChI InChI=1S/C21H32N2O3/c1-14-13-23-18(11-17(14)4-2-3-15-5-6-15)12-21(26,20(24)25)19(22)10-9-16-7-8-16/h11,13,15-16,19,26H,2-10,12,22H2,1H3,(H,24,25)/t19-,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401367
PNG
(US10005762, Example 47)
Show SMILES CC(C)CC[C@H](N)[C@](O)(Cc1cc(CCCC2CC2)c(C)cn1)C(O)=O
Show InChI InChI=1S/C21H34N2O3/c1-14(2)7-10-19(22)21(26,20(24)25)12-18-11-17(15(3)13-23-18)6-4-5-16-8-9-16/h11,13-14,16,19,26H,4-10,12,22H2,1-3H3,(H,24,25)/t19-,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401355
PNG
(US10005762, Example 35)
Show SMILES CSC[C@H](N)[C@](O)(Cc1cc(CCCCC2CC2)c(C)cn1)C(O)=O
Show InChI InChI=1S/C19H30N2O3S/c1-13-11-21-16(9-15(13)6-4-3-5-14-7-8-14)10-19(24,18(22)23)17(20)12-25-2/h9,11,14,17,24H,3-8,10,12,20H2,1-2H3,(H,22,23)/t17-,19+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401322
PNG
(US10005762, Example 4(3))
Show SMILES CCC(O)CCCc1cc(C[C@@](O)([C@@H](N)CC(C)C)C(O)=O)ncc1C
Show InChI InChI=1S/C20H34N2O4/c1-5-17(23)8-6-7-15-10-16(22-12-14(15)4)11-20(26,19(24)25)18(21)9-13(2)3/h10,12-13,17-18,23,26H,5-9,11,21H2,1-4H3,(H,24,25)/t17?,18-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401350
PNG
(US10005762, Example 30)
Show SMILES Cc1cnc(C[C@@](O)([C@@H](N)CC(C)(C)F)C(O)=O)cc1CCCC1CC1
Show InChI InChI=1S/C20H31FN2O3/c1-13-12-23-16(9-15(13)6-4-5-14-7-8-14)10-20(26,18(24)25)17(22)11-19(2,3)21/h9,12,14,17,26H,4-8,10-11,22H2,1-3H3,(H,24,25)/t17-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401369
PNG
(US10005762, Example 49)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(CCCC2(C)CC2)c(C)cn1)C(O)=O
Show InChI InChI=1S/C21H34N2O3/c1-14(2)10-18(22)21(26,19(24)25)12-17-11-16(15(3)13-23-17)6-5-7-20(4)8-9-20/h11,13-14,18,26H,5-10,12,22H2,1-4H3,(H,24,25)/t18-,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401393
PNG
(US10005762, Example 73)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(CCCCC2CC2)c(C)cn1)C(O)=O
Show InChI InChI=1S/C21H34N2O3/c1-14(2)10-19(22)21(26,20(24)25)12-18-11-17(15(3)13-23-18)7-5-4-6-16-8-9-16/h11,13-14,16,19,26H,4-10,12,22H2,1-3H3,(H,24,25)/t19-,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401360
PNG
(US10005762, Example 40)
Show SMILES N[C@@H](CCC1CC1)[C@](O)(Cc1cc(CCCC2CC2)ccn1)C(O)=O
Show InChI InChI=1S/C20H30N2O3/c21-18(9-8-15-6-7-15)20(25,19(23)24)13-17-12-16(10-11-22-17)3-1-2-14-4-5-14/h10-12,14-15,18,25H,1-9,13,21H2,(H,23,24)/t18-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401355
PNG
(US10005762, Example 35)
Show SMILES CSC[C@H](N)[C@](O)(Cc1cc(CCCCC2CC2)c(C)cn1)C(O)=O
Show InChI InChI=1S/C19H30N2O3S/c1-13-11-21-16(9-15(13)6-4-3-5-14-7-8-14)10-19(24,18(22)23)17(20)12-25-2/h9,11,14,17,24H,3-8,10,12,20H2,1-2H3,(H,22,23)/t17-,19+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401317
PNG
(US10005762, Example 1)
Show SMILES CSC[C@H](N)[C@](O)(Cc1cc(CCCC2CC2)c(C)cn1)C(O)=O
Show InChI InChI=1S/C18H28N2O3S/c1-12-10-20-15(8-14(12)5-3-4-13-6-7-13)9-18(23,17(21)22)16(19)11-24-2/h8,10,13,16,23H,3-7,9,11,19H2,1-2H3,(H,21,22)/t16-,18+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401320
PNG
(US10005762, Example 4(1))
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(CCCC2CC2)c(C)cn1)C(O)=O
Show InChI InChI=1S/C20H32N2O3/c1-13(2)9-18(21)20(25,19(23)24)11-17-10-16(14(3)12-22-17)6-4-5-15-7-8-15/h10,12-13,15,18,25H,4-9,11,21H2,1-3H3,(H,23,24)/t18-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401324
PNG
(US10005762, Example 6(1) | US10005762, Example 6(2...)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(ccn1)C1CC1CC1CC1)C(O)=O
Show InChI InChI=1S/C20H30N2O3/c1-12(2)7-18(21)20(25,19(23)24)11-16-9-14(5-6-22-16)17-10-15(17)8-13-3-4-13/h5-6,9,12-13,15,17-18,25H,3-4,7-8,10-11,21H2,1-2H3,(H,23,24)/t15?,17?,18-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401368
PNG
(US10005762, Example 48)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(\C=C\c2ccccc2)c(C)cn1)C(O)=O
Show InChI InChI=1S/C22H28N2O3/c1-15(2)11-20(23)22(27,21(25)26)13-19-12-18(16(3)14-24-19)10-9-17-7-5-4-6-8-17/h4-10,12,14-15,20,27H,11,13,23H2,1-3H3,(H,25,26)/b10-9+/t20-,22+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401356
PNG
(US10005762, Example 36)
Show SMILES CCSC[C@H](N)[C@](O)(Cc1cc(CCCCC2CC2)c(C)cn1)C(O)=O
Show InChI InChI=1S/C20H32N2O3S/c1-3-26-13-18(21)20(25,19(23)24)11-17-10-16(14(2)12-22-17)7-5-4-6-15-8-9-15/h10,12,15,18,25H,3-9,11,13,21H2,1-2H3,(H,23,24)/t18-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401389
PNG
(US10005762, Example 69)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1nccc2CC(CC3(C)CC3)Cc12)C(O)=O
Show InChI InChI=1S/C21H32N2O3/c1-13(2)8-18(22)21(26,19(24)25)12-17-16-10-14(11-20(3)5-6-20)9-15(16)4-7-23-17/h4,7,13-14,18,26H,5-6,8-12,22H2,1-3H3,(H,24,25)/t14?,18-,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401393
PNG
(US10005762, Example 73)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(CCCCC2CC2)c(C)cn1)C(O)=O
Show InChI InChI=1S/C21H34N2O3/c1-14(2)10-19(22)21(26,20(24)25)12-18-11-17(15(3)13-23-18)7-5-4-6-16-8-9-16/h11,13-14,16,19,26H,4-10,12,22H2,1-3H3,(H,24,25)/t19-,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401320
PNG
(US10005762, Example 4(1))
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(CCCC2CC2)c(C)cn1)C(O)=O
Show InChI InChI=1S/C20H32N2O3/c1-13(2)9-18(21)20(25,19(23)24)11-17-10-16(14(3)12-22-17)6-4-5-15-7-8-15/h10,12-13,15,18,25H,4-9,11,21H2,1-3H3,(H,23,24)/t18-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401395
PNG
(US10005762, Example 75)
Show SMILES CCCCCCc1cc(C[C@@](O)([C@@H](N)CC(C)C)C(O)=O)ncc1C
Show InChI InChI=1S/C20H34N2O3/c1-5-6-7-8-9-16-11-17(22-13-15(16)4)12-20(25,19(23)24)18(21)10-14(2)3/h11,13-14,18,25H,5-10,12,21H2,1-4H3,(H,23,24)/t18-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401319
PNG
(US10005762, Example 3)
Show SMILES Cc1cnc(C[C@@](O)([C@@H](N)CCC2CC2)C(O)=O)cc1CCCC1CC1
Show InChI InChI=1S/C21H32N2O3/c1-14-13-23-18(11-17(14)4-2-3-15-5-6-15)12-21(26,20(24)25)19(22)10-9-16-7-8-16/h11,13,15-16,19,26H,2-10,12,22H2,1H3,(H,24,25)/t19-,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401354
PNG
(US10005762, Example 34)
Show SMILES CCSC[C@H](N)[C@](O)(Cc1cc(CCCC2CC2)c(C)cn1)C(O)=O
Show InChI InChI=1S/C19H30N2O3S/c1-3-25-12-17(20)19(24,18(22)23)10-16-9-15(13(2)11-21-16)6-4-5-14-7-8-14/h9,11,14,17,24H,3-8,10,12,20H2,1-2H3,(H,22,23)/t17-,19+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401364
PNG
(US10005762, Example 44)
Show SMILES CSC[C@H](N)[C@](O)(Cc1nccc2C[C@H](CCC3CC3)Cc12)C(O)=O
Show InChI InChI=1S/C19H28N2O3S/c1-25-11-17(20)19(24,18(22)23)10-16-15-9-13(5-4-12-2-3-12)8-14(15)6-7-21-16/h6-7,12-13,17,24H,2-5,8-11,20H2,1H3,(H,22,23)/t13-,17-,19+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401394
PNG
(US10005762, Example 74)
Show SMILES CCCCCc1cc(C[C@@](O)([C@@H](N)CC(C)C)C(O)=O)ncc1C
Show InChI InChI=1S/C19H32N2O3/c1-5-6-7-8-15-10-16(21-12-14(15)4)11-19(24,18(22)23)17(20)9-13(2)3/h10,12-13,17,24H,5-9,11,20H2,1-4H3,(H,22,23)/t17-,19+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401322
PNG
(US10005762, Example 4(3))
Show SMILES CCC(O)CCCc1cc(C[C@@](O)([C@@H](N)CC(C)C)C(O)=O)ncc1C
Show InChI InChI=1S/C20H34N2O4/c1-5-17(23)8-6-7-15-10-16(22-12-14(15)4)11-20(26,19(24)25)18(21)9-13(2)3/h10,12-13,17-18,23,26H,5-9,11,21H2,1-4H3,(H,24,25)/t17?,18-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401370
PNG
(US10005762, Example 50)
Show SMILES CCC(C)(O)CCCc1cc(C[C@@](O)([C@@H](N)CC(C)C)C(O)=O)ncc1C
Show InChI InChI=1S/C21H36N2O4/c1-6-20(5,26)9-7-8-16-11-17(23-13-15(16)4)12-21(27,19(24)25)18(22)10-14(2)3/h11,13-14,18,26-27H,6-10,12,22H2,1-5H3,(H,24,25)/t18-,20?,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401321
PNG
(US10005762, Example 4(2))
Show SMILES CCC(Cl)CCCc1cc(C[C@@](O)([C@@H](N)CC(C)C)C(O)=O)ncc1C
Show InChI InChI=1S/C20H33ClN2O3/c1-5-16(21)8-6-7-15-10-17(23-12-14(15)4)11-20(26,19(24)25)18(22)9-13(2)3/h10,12-13,16,18,26H,5-9,11,22H2,1-4H3,(H,24,25)/t16?,18-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401350
PNG
(US10005762, Example 30)
Show SMILES Cc1cnc(C[C@@](O)([C@@H](N)CC(C)(C)F)C(O)=O)cc1CCCC1CC1
Show InChI InChI=1S/C20H31FN2O3/c1-13-12-23-16(9-15(13)6-4-5-14-7-8-14)10-20(26,18(24)25)17(22)11-19(2,3)21/h9,12,14,17,26H,4-8,10-11,22H2,1-3H3,(H,24,25)/t17-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401395
PNG
(US10005762, Example 75)
Show SMILES CCCCCCc1cc(C[C@@](O)([C@@H](N)CC(C)C)C(O)=O)ncc1C
Show InChI InChI=1S/C20H34N2O3/c1-5-6-7-8-9-16-11-17(22-13-15(16)4)12-20(25,19(23)24)18(21)10-14(2)3/h11,13-14,18,25H,5-10,12,21H2,1-4H3,(H,23,24)/t18-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401392
PNG
(US10005762, Example 72)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(COC2CCCCC2)c(C)cn1)C(O)=O
Show InChI InChI=1S/C21H34N2O4/c1-14(2)9-19(22)21(26,20(24)25)11-17-10-16(15(3)12-23-17)13-27-18-7-5-4-6-8-18/h10,12,14,18-19,26H,4-9,11,13,22H2,1-3H3,(H,24,25)/t19-,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401394
PNG
(US10005762, Example 74)
Show SMILES CCCCCc1cc(C[C@@](O)([C@@H](N)CC(C)C)C(O)=O)ncc1C
Show InChI InChI=1S/C19H32N2O3/c1-5-6-7-8-15-10-16(21-12-14(15)4)11-19(24,18(22)23)17(20)9-13(2)3/h10,12-13,17,24H,5-9,11,20H2,1-4H3,(H,22,23)/t17-,19+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401351
PNG
(US10005762, Example 31)
Show SMILES Cc1cnc(C[C@@](O)([C@@H](N)CC2(C)CC2)C(O)=O)cc1CCCC1CC1
Show InChI InChI=1S/C21H32N2O3/c1-14-13-23-17(10-16(14)5-3-4-15-6-7-15)11-21(26,19(24)25)18(22)12-20(2)8-9-20/h10,13,15,18,26H,3-9,11-12,22H2,1-2H3,(H,24,25)/t18-,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401317
PNG
(US10005762, Example 1)
Show SMILES CSC[C@H](N)[C@](O)(Cc1cc(CCCC2CC2)c(C)cn1)C(O)=O
Show InChI InChI=1S/C18H28N2O3S/c1-12-10-20-15(8-14(12)5-3-4-13-6-7-13)9-18(23,17(21)22)16(19)11-24-2/h8,10,13,16,23H,3-7,9,11,19H2,1-2H3,(H,21,22)/t16-,18+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401367
PNG
(US10005762, Example 47)
Show SMILES CC(C)CC[C@H](N)[C@](O)(Cc1cc(CCCC2CC2)c(C)cn1)C(O)=O
Show InChI InChI=1S/C21H34N2O3/c1-14(2)7-10-19(22)21(26,20(24)25)12-18-11-17(15(3)13-23-18)6-4-5-16-8-9-16/h11,13-14,16,19,26H,4-10,12,22H2,1-3H3,(H,24,25)/t19-,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401369
PNG
(US10005762, Example 49)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(CCCC2(C)CC2)c(C)cn1)C(O)=O
Show InChI InChI=1S/C21H34N2O3/c1-14(2)10-18(22)21(26,19(24)25)12-17-11-16(15(3)13-23-17)6-5-7-20(4)8-9-20/h11,13-14,18,26H,5-10,12,22H2,1-4H3,(H,24,25)/t18-,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401388
PNG
(US10005762, Example 68)
Show SMILES CC(C)CCc1cc(C[C@@](O)([C@@H](N)CC(C)C)C(O)=O)ncc1C
Show InChI InChI=1S/C19H32N2O3/c1-12(2)6-7-15-9-16(21-11-14(15)5)10-19(24,18(22)23)17(20)8-13(3)4/h9,11-13,17,24H,6-8,10,20H2,1-5H3,(H,22,23)/t17-,19+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401347
PNG
(US10005762, Example 27)
Show SMILES Cc1cnc(C[C@@](O)([C@@H](N)COCC2CC2)C(O)=O)cc1CCCC1CC1
Show InChI InChI=1S/C21H32N2O4/c1-14-11-23-18(9-17(14)4-2-3-15-5-6-15)10-21(26,20(24)25)19(22)13-27-12-16-7-8-16/h9,11,15-16,19,26H,2-8,10,12-13,22H2,1H3,(H,24,25)/t19-,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401365
PNG
(US10005762, Example 45)
Show SMILES CCSC[C@H](N)[C@](O)(Cc1nccc2C[C@H](CCC3CC3)Cc12)C(O)=O
Show InChI InChI=1S/C20H30N2O3S/c1-2-26-12-18(21)20(25,19(23)24)11-17-16-10-14(6-5-13-3-4-13)9-15(16)7-8-22-17/h7-8,13-14,18,25H,2-6,9-12,21H2,1H3,(H,23,24)/t14-,18-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401391
PNG
(US10005762, Example 71)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(CC2CCCC2)c(C)cn1)C(O)=O
Show InChI InChI=1S/C20H32N2O3/c1-13(2)8-18(21)20(25,19(23)24)11-17-10-16(14(3)12-22-17)9-15-6-4-5-7-15/h10,12-13,15,18,25H,4-9,11,21H2,1-3H3,(H,23,24)/t18-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401371
PNG
(US10005762, Example 51)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1nccc2CC(CC(C)C)Cc12)C(O)=O
Show InChI InChI=1S/C20H32N2O3/c1-12(2)7-14-9-15-5-6-22-17(16(15)10-14)11-20(25,19(23)24)18(21)8-13(3)4/h5-6,12-14,18,25H,7-11,21H2,1-4H3,(H,23,24)/t14?,18-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401375
PNG
(US10005762, Example 55)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1nccc2C[C@H](CC3CC3)Cc12)C(O)=O
Show InChI InChI=1S/C20H30N2O3/c1-12(2)7-18(21)20(25,19(23)24)11-17-16-10-14(8-13-3-4-13)9-15(16)5-6-22-17/h5-6,12-14,18,25H,3-4,7-11,21H2,1-2H3,(H,23,24)/t14-,18-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401351
PNG
(US10005762, Example 31)
Show SMILES Cc1cnc(C[C@@](O)([C@@H](N)CC2(C)CC2)C(O)=O)cc1CCCC1CC1
Show InChI InChI=1S/C21H32N2O3/c1-14-13-23-17(10-16(14)5-3-4-15-6-7-15)11-21(26,19(24)25)18(22)12-20(2)8-9-20/h10,13,15,18,26H,3-9,11-12,22H2,1-2H3,(H,24,25)/t18-,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401361
PNG
(US10005762, Example 41)
Show SMILES CSC[C@H](N)[C@](O)(Cc1nccc2C[C@@H](CCC3CC3)Cc12)C(O)=O
Show InChI InChI=1S/C19H28N2O3S/c1-25-11-17(20)19(24,18(22)23)10-16-15-9-13(5-4-12-2-3-12)8-14(15)6-7-21-16/h6-7,12-13,17,24H,2-5,8-11,20H2,1H3,(H,22,23)/t13-,17+,19-/m1/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401361
PNG
(US10005762, Example 41)
Show SMILES CSC[C@H](N)[C@](O)(Cc1nccc2C[C@@H](CCC3CC3)Cc12)C(O)=O
Show InChI InChI=1S/C19H28N2O3S/c1-25-11-17(20)19(24,18(22)23)10-16-15-9-13(5-4-12-2-3-12)8-14(15)6-7-21-16/h6-7,12-13,17,24H,2-5,8-11,20H2,1H3,(H,22,23)/t13-,17+,19-/m1/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401392
PNG
(US10005762, Example 72)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(COC2CCCCC2)c(C)cn1)C(O)=O
Show InChI InChI=1S/C21H34N2O4/c1-14(2)9-19(22)21(26,20(24)25)11-17-10-16(15(3)12-23-17)13-27-18-7-5-4-6-8-18/h10,12,14,18-19,26H,4-9,11,13,22H2,1-3H3,(H,24,25)/t19-,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401358
PNG
(US10005762, Example 38)
Show SMILES CC(C)CC[C@H](N)[C@](O)(Cc1cc(CCCC2CC2)ccn1)C(O)=O
Show InChI InChI=1S/C20H32N2O3/c1-14(2)6-9-18(21)20(25,19(23)24)13-17-12-16(10-11-22-17)5-3-4-15-7-8-15/h10-12,14-15,18,25H,3-9,13,21H2,1-2H3,(H,23,24)/t18-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401372
PNG
(US10005762, Example 52)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1nccc2C[C@@H](CCC3CC3)Cc12)C(O)=O
Show InChI InChI=1S/C21H32N2O3/c1-13(2)9-19(22)21(26,20(24)25)12-18-17-11-15(6-5-14-3-4-14)10-16(17)7-8-23-18/h7-8,13-15,19,26H,3-6,9-12,22H2,1-2H3,(H,24,25)/t15-,19+,21-/m1/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401323
PNG
(US10005762, Example 5)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1nccc2C[C@H](CCC3CC3)Cc12)C(O)=O
Show InChI InChI=1S/C21H32N2O3/c1-13(2)9-19(22)21(26,20(24)25)12-18-17-11-15(6-5-14-3-4-14)10-16(17)7-8-23-18/h7-8,13-15,19,26H,3-6,9-12,22H2,1-2H3,(H,24,25)/t15-,19-,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401375
PNG
(US10005762, Example 55)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1nccc2C[C@H](CC3CC3)Cc12)C(O)=O
Show InChI InChI=1S/C20H30N2O3/c1-12(2)7-18(21)20(25,19(23)24)11-17-16-10-14(8-13-3-4-13)9-15(16)5-6-22-17/h5-6,12-14,18,25H,3-4,7-11,21H2,1-2H3,(H,23,24)/t14-,18-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401324
PNG
(US10005762, Example 6(1) | US10005762, Example 6(2...)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(ccn1)C1CC1CC1CC1)C(O)=O
Show InChI InChI=1S/C20H30N2O3/c1-12(2)7-18(21)20(25,19(23)24)11-16-9-14(5-6-22-16)17-10-15(17)8-13-3-4-13/h5-6,9,12-13,15,17-18,25H,3-4,7-8,10-11,21H2,1-2H3,(H,23,24)/t15?,17?,18-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401323
PNG
(US10005762, Example 5)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1nccc2C[C@H](CCC3CC3)Cc12)C(O)=O
Show InChI InChI=1S/C21H32N2O3/c1-13(2)9-19(22)21(26,20(24)25)12-18-17-11-15(6-5-14-3-4-14)10-16(17)7-8-23-18/h7-8,13-15,19,26H,3-6,9-12,22H2,1-2H3,(H,24,25)/t15-,19-,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401373
PNG
(US10005762, Example 53)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(CCCC2CC2)ccn1)C(O)=O
Show InChI InChI=1S/C19H30N2O3/c1-13(2)10-17(20)19(24,18(22)23)12-16-11-15(8-9-21-16)5-3-4-14-6-7-14/h8-9,11,13-14,17,24H,3-7,10,12,20H2,1-2H3,(H,22,23)/t17-,19+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401372
PNG
(US10005762, Example 52)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1nccc2C[C@@H](CCC3CC3)Cc12)C(O)=O
Show InChI InChI=1S/C21H32N2O3/c1-13(2)9-19(22)21(26,20(24)25)12-18-17-11-15(6-5-14-3-4-14)10-16(17)7-8-23-18/h7-8,13-15,19,26H,3-6,9-12,22H2,1-2H3,(H,24,25)/t15-,19+,21-/m1/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401336
PNG
(US10005762, Example 16)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc2[C@H](CCC3CC3)CCc2cn1)C(O)=O
Show InChI InChI=1S/C21H32N2O3/c1-13(2)9-19(22)21(26,20(24)25)11-17-10-18-15(6-5-14-3-4-14)7-8-16(18)12-23-17/h10,12-15,19,26H,3-9,11,22H2,1-2H3,(H,24,25)/t15-,19+,21-/m1/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401370
PNG
(US10005762, Example 50)
Show SMILES CCC(C)(O)CCCc1cc(C[C@@](O)([C@@H](N)CC(C)C)C(O)=O)ncc1C
Show InChI InChI=1S/C21H36N2O4/c1-6-20(5,26)9-7-8-16-11-17(23-13-15(16)4)12-21(27,19(24)25)18(22)10-14(2)3/h11,13-14,18,26-27H,6-10,12,22H2,1-5H3,(H,24,25)/t18-,20?,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401321
PNG
(US10005762, Example 4(2))
Show SMILES CCC(Cl)CCCc1cc(C[C@@](O)([C@@H](N)CC(C)C)C(O)=O)ncc1C
Show InChI InChI=1S/C20H33ClN2O3/c1-5-16(21)8-6-7-15-10-17(23-12-14(15)4)11-20(26,19(24)25)18(22)9-13(2)3/h10,12-13,16,18,26H,5-9,11,22H2,1-4H3,(H,24,25)/t16?,18-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401390
PNG
(US10005762, Example 70)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(C2CCCC2)c(C)cn1)C(O)=O
Show InChI InChI=1S/C19H30N2O3/c1-12(2)8-17(20)19(24,18(22)23)10-15-9-16(13(3)11-21-15)14-6-4-5-7-14/h9,11-12,14,17,24H,4-8,10,20H2,1-3H3,(H,22,23)/t17-,19+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401359
PNG
(US10005762, Example 39)
Show SMILES N[C@@H](CCC1CCC1)[C@](O)(Cc1cc(CCCC2CC2)ccn1)C(O)=O
Show InChI InChI=1S/C21H32N2O3/c22-19(10-9-15-3-1-4-15)21(26,20(24)25)14-18-13-17(11-12-23-18)6-2-5-16-7-8-16/h11-13,15-16,19,26H,1-10,14,22H2,(H,24,25)/t19-,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401364
PNG
(US10005762, Example 44)
Show SMILES CSC[C@H](N)[C@](O)(Cc1nccc2C[C@H](CCC3CC3)Cc12)C(O)=O
Show InChI InChI=1S/C19H28N2O3S/c1-25-11-17(20)19(24,18(22)23)10-16-15-9-13(5-4-12-2-3-12)8-14(15)6-7-21-16/h6-7,12-13,17,24H,2-5,8-11,20H2,1H3,(H,22,23)/t13-,17-,19+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401356
PNG
(US10005762, Example 36)
Show SMILES CCSC[C@H](N)[C@](O)(Cc1cc(CCCCC2CC2)c(C)cn1)C(O)=O
Show InChI InChI=1S/C20H32N2O3S/c1-3-26-13-18(21)20(25,19(23)24)11-17-10-16(14(2)12-22-17)7-5-4-6-15-8-9-15/h10,12,15,18,25H,3-9,11,13,21H2,1-2H3,(H,23,24)/t18-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401366
PNG
(US10005762, Example 46)
Show SMILES CCCSC[C@H](N)[C@](O)(Cc1nccc2C[C@H](CCC3CC3)Cc12)C(O)=O
Show InChI InChI=1S/C21H32N2O3S/c1-2-9-27-13-19(22)21(26,20(24)25)12-18-17-11-15(6-5-14-3-4-14)10-16(17)7-8-23-18/h7-8,14-15,19,26H,2-6,9-13,22H2,1H3,(H,24,25)/t15-,19-,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401373
PNG
(US10005762, Example 53)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(CCCC2CC2)ccn1)C(O)=O
Show InChI InChI=1S/C19H30N2O3/c1-13(2)10-17(20)19(24,18(22)23)12-16-11-15(8-9-21-16)5-3-4-14-6-7-14/h8-9,11,13-14,17,24H,3-7,10,12,20H2,1-2H3,(H,22,23)/t17-,19+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401368
PNG
(US10005762, Example 48)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(\C=C\c2ccccc2)c(C)cn1)C(O)=O
Show InChI InChI=1S/C22H28N2O3/c1-15(2)11-20(23)22(27,21(25)26)13-19-12-18(16(3)14-24-19)10-9-17-7-5-4-6-8-17/h4-10,12,14-15,20,27H,11,13,23H2,1-3H3,(H,25,26)/b10-9+/t20-,22+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401389
PNG
(US10005762, Example 69)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1nccc2CC(CC3(C)CC3)Cc12)C(O)=O
Show InChI InChI=1S/C21H32N2O3/c1-13(2)8-18(22)21(26,19(24)25)12-17-16-10-14(11-20(3)5-6-20)9-15(16)4-7-23-17/h4,7,13-14,18,26H,5-6,8-12,22H2,1-3H3,(H,24,25)/t14?,18-,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401349
PNG
(US10005762, Example 29)
Show SMILES CC(C)(F)C[C@H](N)[C@](O)(Cc1nccc2C[C@@H](CCC3CC3)Cc12)C(O)=O
Show InChI InChI=1S/C21H31FN2O3/c1-20(2,22)12-18(23)21(27,19(25)26)11-17-16-10-14(6-5-13-3-4-13)9-15(16)7-8-24-17/h7-8,13-14,18,27H,3-6,9-12,23H2,1-2H3,(H,25,26)/t14-,18+,21-/m1/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401345
PNG
(US10005762, Example 25)
Show SMILES Cc1cnc(C[C@@](O)([C@@H](N)COCCC2CC2)C(O)=O)cc1CCCC1CC1
Show InChI InChI=1S/C22H34N2O4/c1-15-13-24-19(11-18(15)4-2-3-16-5-6-16)12-22(27,21(25)26)20(23)14-28-10-9-17-7-8-17/h11,13,16-17,20,27H,2-10,12,14,23H2,1H3,(H,25,26)/t20-,22+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401332
PNG
(US10005762, Example 12)
Show SMILES COc1ccccc1CCc1ccnc(C[C@@](O)([C@@H](N)CC(C)C)C(O)=O)c1
Show InChI InChI=1S/C22H30N2O4/c1-15(2)12-20(23)22(27,21(25)26)14-18-13-16(10-11-24-18)8-9-17-6-4-5-7-19(17)28-3/h4-7,10-11,13,15,20,27H,8-9,12,14,23H2,1-3H3,(H,25,26)/t20-,22+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401354
PNG
(US10005762, Example 34)
Show SMILES CCSC[C@H](N)[C@](O)(Cc1cc(CCCC2CC2)c(C)cn1)C(O)=O
Show InChI InChI=1S/C19H30N2O3S/c1-3-25-12-17(20)19(24,18(22)23)10-16-9-15(13(2)11-21-16)6-4-5-14-7-8-14/h9,11,14,17,24H,3-8,10,12,20H2,1-2H3,(H,22,23)/t17-,19+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401327
PNG
(US10005762, Example 8)
Show SMILES CCCCCc1ccnc(C[C@@](O)([C@@H](N)CC(C)C)C(O)=O)c1
Show InChI InChI=1S/C18H30N2O3/c1-4-5-6-7-14-8-9-20-15(11-14)12-18(23,17(21)22)16(19)10-13(2)3/h8-9,11,13,16,23H,4-7,10,12,19H2,1-3H3,(H,21,22)/t16-,18+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401381
PNG
(US10005762, Example 61)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(CCc2cccc(C)c2)ccn1)C(O)=O
Show InChI InChI=1S/C22H30N2O3/c1-15(2)11-20(23)22(27,21(25)26)14-19-13-18(9-10-24-19)8-7-17-6-4-5-16(3)12-17/h4-6,9-10,12-13,15,20,27H,7-8,11,14,23H2,1-3H3,(H,25,26)/t20-,22+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401332
PNG
(US10005762, Example 12)
Show SMILES COc1ccccc1CCc1ccnc(C[C@@](O)([C@@H](N)CC(C)C)C(O)=O)c1
Show InChI InChI=1S/C22H30N2O4/c1-15(2)12-20(23)22(27,21(25)26)14-18-13-16(10-11-24-18)8-9-17-6-4-5-7-19(17)28-3/h4-7,10-11,13,15,20,27H,8-9,12,14,23H2,1-3H3,(H,25,26)/t20-,22+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401374
PNG
(US10005762, Example 54)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1nccc2C[C@@H](CC3CC3)Cc12)C(O)=O
Show InChI InChI=1S/C20H30N2O3/c1-12(2)7-18(21)20(25,19(23)24)11-17-16-10-14(8-13-3-4-13)9-15(16)5-6-22-17/h5-6,12-14,18,25H,3-4,7-11,21H2,1-2H3,(H,23,24)/t14-,18+,20-/m1/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401340
PNG
(US10005762, Example 20)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(CC(C)CC2CC2)ccn1)C(O)=O
Show InChI InChI=1S/C20H32N2O3/c1-13(2)8-18(21)20(25,19(23)24)12-17-11-16(6-7-22-17)10-14(3)9-15-4-5-15/h6-7,11,13-15,18,25H,4-5,8-10,12,21H2,1-3H3,(H,23,24)/t14?,18-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401363
PNG
(US10005762, Example 43)
Show SMILES CC(C)SC[C@H](N)[C@](O)(Cc1nccc2C[C@@H](CCC3CC3)Cc12)C(O)=O
Show InChI InChI=1S/C21H32N2O3S/c1-13(2)27-12-19(22)21(26,20(24)25)11-18-17-10-15(6-5-14-3-4-14)9-16(17)7-8-23-18/h7-8,13-15,19,26H,3-6,9-12,22H2,1-2H3,(H,24,25)/t15-,19+,21-/m1/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401383
PNG
(US10005762, Example 63)
Show SMILES CCC1CCc2c(C1)ccnc2C[C@@](O)([C@@H](N)CC(C)C)C(O)=O
Show InChI InChI=1S/C19H30N2O3/c1-4-13-5-6-15-14(10-13)7-8-21-16(15)11-19(24,18(22)23)17(20)9-12(2)3/h7-8,12-13,17,24H,4-6,9-11,20H2,1-3H3,(H,22,23)/t13?,17-,19+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401374
PNG
(US10005762, Example 54)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1nccc2C[C@@H](CC3CC3)Cc12)C(O)=O
Show InChI InChI=1S/C20H30N2O3/c1-12(2)7-18(21)20(25,19(23)24)11-17-16-10-14(8-13-3-4-13)9-15(16)5-6-22-17/h5-6,12-14,18,25H,3-4,7-11,21H2,1-2H3,(H,23,24)/t14-,18+,20-/m1/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401328
PNG
(US10005762, Example 9)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1nccc2CC(CC3CC3)CCc12)C(O)=O
Show InChI InChI=1S/C21H32N2O3/c1-13(2)9-19(22)21(26,20(24)25)12-18-17-6-5-15(10-14-3-4-14)11-16(17)7-8-23-18/h7-8,13-15,19,26H,3-6,9-12,22H2,1-2H3,(H,24,25)/t15?,19-,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401371
PNG
(US10005762, Example 51)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1nccc2CC(CC(C)C)Cc12)C(O)=O
Show InChI InChI=1S/C20H32N2O3/c1-12(2)7-14-9-15-5-6-22-17(16(15)10-14)11-20(25,19(23)24)18(21)8-13(3)4/h5-6,12-14,18,25H,7-11,21H2,1-4H3,(H,23,24)/t14?,18-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401362
PNG
(US10005762, Example 42)
Show SMILES CCCSC[C@H](N)[C@](O)(Cc1nccc2C[C@@H](CCC3CC3)Cc12)C(O)=O
Show InChI InChI=1S/C21H32N2O3S/c1-2-9-27-13-19(22)21(26,20(24)25)12-18-17-11-15(6-5-14-3-4-14)10-16(17)7-8-23-18/h7-8,14-15,19,26H,2-6,9-13,22H2,1H3,(H,24,25)/t15-,19+,21-/m1/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401331
PNG
(US10005762, Example 11)
Show SMILES CCCC1CC1c1ccnc(C[C@@](O)([C@@H](N)CC(C)C)C(O)=O)c1
Show InChI InChI=1S/C19H30N2O3/c1-4-5-13-10-16(13)14-6-7-21-15(9-14)11-19(24,18(22)23)17(20)8-12(2)3/h6-7,9,12-13,16-17,24H,4-5,8,10-11,20H2,1-3H3,(H,22,23)/t13?,16?,17-,19+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401357
PNG
(US10005762, Example 37)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(ccn1)C1=CCN(CC1)C(=O)OCc1ccccc1)C(O)=O
Show InChI InChI=1S/C26H33N3O5/c1-18(2)14-23(27)26(33,24(30)31)16-22-15-21(8-11-28-22)20-9-12-29(13-10-20)25(32)34-17-19-6-4-3-5-7-19/h3-9,11,15,18,23,33H,10,12-14,16-17,27H2,1-2H3,(H,30,31)/t23-,26+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401365
PNG
(US10005762, Example 45)
Show SMILES CCSC[C@H](N)[C@](O)(Cc1nccc2C[C@H](CCC3CC3)Cc12)C(O)=O
Show InChI InChI=1S/C20H30N2O3S/c1-2-26-12-18(21)20(25,19(23)24)11-17-16-10-14(6-5-13-3-4-13)9-15(16)7-8-22-17/h7-8,13-14,18,25H,2-6,9-12,21H2,1H3,(H,23,24)/t14-,18-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401357
PNG
(US10005762, Example 37)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(ccn1)C1=CCN(CC1)C(=O)OCc1ccccc1)C(O)=O
Show InChI InChI=1S/C26H33N3O5/c1-18(2)14-23(27)26(33,24(30)31)16-22-15-21(8-11-28-22)20-9-12-29(13-10-20)25(32)34-17-19-6-4-3-5-7-19/h3-9,11,15,18,23,33H,10,12-14,16-17,27H2,1-2H3,(H,30,31)/t23-,26+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401378
PNG
(US10005762, Example 58)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(ccn1)C1=CCCCC1)C(O)=O
Show InChI InChI=1S/C19H28N2O3/c1-13(2)10-17(20)19(24,18(22)23)12-16-11-15(8-9-21-16)14-6-4-3-5-7-14/h6,8-9,11,13,17,24H,3-5,7,10,12,20H2,1-2H3,(H,22,23)/t17-,19+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401384
PNG
(US10005762, Example 64)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(Cc2ccccc2)c(C)cn1)C(O)=O
Show InChI InChI=1S/C21H28N2O3/c1-14(2)9-19(22)21(26,20(24)25)12-18-11-17(15(3)13-23-18)10-16-7-5-4-6-8-16/h4-8,11,13-14,19,26H,9-10,12,22H2,1-3H3,(H,24,25)/t19-,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401327
PNG
(US10005762, Example 8)
Show SMILES CCCCCc1ccnc(C[C@@](O)([C@@H](N)CC(C)C)C(O)=O)c1
Show InChI InChI=1S/C18H30N2O3/c1-4-5-6-7-14-8-9-20-15(11-14)12-18(23,17(21)22)16(19)10-13(2)3/h8-9,11,13,16,23H,4-7,10,12,19H2,1-3H3,(H,21,22)/t16-,18+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401336
PNG
(US10005762, Example 16)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc2[C@H](CCC3CC3)CCc2cn1)C(O)=O
Show InChI InChI=1S/C21H32N2O3/c1-13(2)9-19(22)21(26,20(24)25)11-17-10-18-15(6-5-14-3-4-14)7-8-16(18)12-23-17/h10,12-15,19,26H,3-9,11,22H2,1-2H3,(H,24,25)/t15-,19+,21-/m1/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401331
PNG
(US10005762, Example 11)
Show SMILES CCCC1CC1c1ccnc(C[C@@](O)([C@@H](N)CC(C)C)C(O)=O)c1
Show InChI InChI=1S/C19H30N2O3/c1-4-5-13-10-16(13)14-6-7-21-15(9-14)11-19(24,18(22)23)17(20)8-12(2)3/h6-7,9,12-13,16-17,24H,4-5,8,10-11,20H2,1-3H3,(H,22,23)/t13?,16?,17-,19+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401342
PNG
(US10005762, Example 22)
Show SMILES N[C@@H](CSCCC1CC1)[C@](O)(Cc1cc(CCCC2CC2)ccn1)C(O)=O
Show InChI InChI=1S/C21H32N2O3S/c22-19(14-27-11-9-16-6-7-16)21(26,20(24)25)13-18-12-17(8-10-23-18)3-1-2-15-4-5-15/h8,10,12,15-16,19,26H,1-7,9,11,13-14,22H2,(H,24,25)/t19-,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401388
PNG
(US10005762, Example 68)
Show SMILES CC(C)CCc1cc(C[C@@](O)([C@@H](N)CC(C)C)C(O)=O)ncc1C
Show InChI InChI=1S/C19H32N2O3/c1-12(2)6-7-15-9-16(21-11-14(15)5)10-19(24,18(22)23)17(20)8-13(3)4/h9,11-13,17,24H,6-8,10,20H2,1-5H3,(H,22,23)/t17-,19+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401362
PNG
(US10005762, Example 42)
Show SMILES CCCSC[C@H](N)[C@](O)(Cc1nccc2C[C@@H](CCC3CC3)Cc12)C(O)=O
Show InChI InChI=1S/C21H32N2O3S/c1-2-9-27-13-19(22)21(26,20(24)25)12-18-17-11-15(6-5-14-3-4-14)10-16(17)7-8-23-18/h7-8,14-15,19,26H,2-6,9-13,22H2,1H3,(H,24,25)/t15-,19+,21-/m1/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401337
PNG
(US10005762, Example 17)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc2[C@@H](CCC3CC3)CCc2cn1)C(O)=O
Show InChI InChI=1S/C21H32N2O3/c1-13(2)9-19(22)21(26,20(24)25)11-17-10-18-15(6-5-14-3-4-14)7-8-16(18)12-23-17/h10,12-15,19,26H,3-9,11,22H2,1-2H3,(H,24,25)/t15-,19-,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401391
PNG
(US10005762, Example 71)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(CC2CCCC2)c(C)cn1)C(O)=O
Show InChI InChI=1S/C20H32N2O3/c1-13(2)8-18(21)20(25,19(23)24)11-17-10-16(14(3)12-22-17)9-15-6-4-5-7-15/h10,12-13,15,18,25H,4-9,11,21H2,1-3H3,(H,23,24)/t18-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401318
PNG
(US10005762, Example 2)
Show SMILES N[C@@H](CSCC=C)[C@](O)(Cc1cc(CCCC2CC2)ccn1)C(O)=O
Show InChI InChI=1S/C19H28N2O3S/c1-2-10-25-13-17(20)19(24,18(22)23)12-16-11-15(8-9-21-16)5-3-4-14-6-7-14/h2,8-9,11,14,17,24H,1,3-7,10,12-13,20H2,(H,22,23)/t17-,19+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401381
PNG
(US10005762, Example 61)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(CCc2cccc(C)c2)ccn1)C(O)=O
Show InChI InChI=1S/C22H30N2O3/c1-15(2)11-20(23)22(27,21(25)26)14-19-13-18(9-10-24-19)8-7-17-6-4-5-16(3)12-17/h4-6,9-10,12-13,15,20,27H,7-8,11,14,23H2,1-3H3,(H,25,26)/t20-,22+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401344
PNG
(US10005762, Example 24)
Show SMILES N[C@@H](CSC1CCC1)[C@](O)(Cc1cc(CCCC2CC2)ccn1)C(O)=O
Show InChI InChI=1S/C20H30N2O3S/c21-18(13-26-17-5-2-6-17)20(25,19(23)24)12-16-11-15(9-10-22-16)4-1-3-14-7-8-14/h9-11,14,17-18,25H,1-8,12-13,21H2,(H,23,24)/t18-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401338
PNG
(US10005762, Example 18)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(CCC2CC2)c(cn1)C1CC1)C(O)=O
Show InChI InChI=1S/C21H32N2O3/c1-13(2)9-19(22)21(26,20(24)25)11-17-10-16(6-5-14-3-4-14)18(12-23-17)15-7-8-15/h10,12-15,19,26H,3-9,11,22H2,1-2H3,(H,24,25)/t19-,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401338
PNG
(US10005762, Example 18)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(CCC2CC2)c(cn1)C1CC1)C(O)=O
Show InChI InChI=1S/C21H32N2O3/c1-13(2)9-19(22)21(26,20(24)25)11-17-10-16(6-5-14-3-4-14)18(12-23-17)15-7-8-15/h10,12-15,19,26H,3-9,11,22H2,1-2H3,(H,24,25)/t19-,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401347
PNG
(US10005762, Example 27)
Show SMILES Cc1cnc(C[C@@](O)([C@@H](N)COCC2CC2)C(O)=O)cc1CCCC1CC1
Show InChI InChI=1S/C21H32N2O4/c1-14-11-23-18(9-17(14)4-2-3-15-5-6-15)10-21(26,20(24)25)19(22)13-27-12-16-7-8-16/h9,11,15-16,19,26H,2-8,10,12-13,22H2,1H3,(H,24,25)/t19-,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401348
PNG
(US10005762, Example 28)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1nccc2CC3(Cc12)CCCCC3)C(O)=O
Show InChI InChI=1S/C21H32N2O3/c1-14(2)10-18(22)21(26,19(24)25)13-17-16-12-20(7-4-3-5-8-20)11-15(16)6-9-23-17/h6,9,14,18,26H,3-5,7-8,10-13,22H2,1-2H3,(H,24,25)/t18-,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401333
PNG
(US10005762, Example 13)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(C2CCC3(CC3)CC2)c(C)cn1)C(O)=O
Show InChI InChI=1S/C22H34N2O3/c1-14(2)10-19(23)22(27,20(25)26)12-17-11-18(15(3)13-24-17)16-4-6-21(7-5-16)8-9-21/h11,13-14,16,19,27H,4-10,12,23H2,1-3H3,(H,25,26)/t19-,22+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401384
PNG
(US10005762, Example 64)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(Cc2ccccc2)c(C)cn1)C(O)=O
Show InChI InChI=1S/C21H28N2O3/c1-14(2)9-19(22)21(26,20(24)25)12-18-11-17(15(3)13-23-18)10-16-7-5-4-6-8-16/h4-8,11,13-14,19,26H,9-10,12,22H2,1-3H3,(H,24,25)/t19-,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401363
PNG
(US10005762, Example 43)
Show SMILES CC(C)SC[C@H](N)[C@](O)(Cc1nccc2C[C@@H](CCC3CC3)Cc12)C(O)=O
Show InChI InChI=1S/C21H32N2O3S/c1-13(2)27-12-19(22)21(26,20(24)25)11-18-17-10-15(6-5-14-3-4-14)9-16(17)7-8-23-18/h7-8,13-15,19,26H,3-6,9-12,22H2,1-2H3,(H,24,25)/t15-,19+,21-/m1/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401353
PNG
(US10005762, Example 33)
Show SMILES N[C@@H](COCCC1CC1)[C@](O)(Cc1nccc2C[C@@H](CCC3CC3)Cc12)C(O)=O
Show InChI InChI=1S/C23H34N2O4/c24-21(14-29-10-8-16-3-4-16)23(28,22(26)27)13-20-19-12-17(6-5-15-1-2-15)11-18(19)7-9-25-20/h7,9,15-17,21,28H,1-6,8,10-14,24H2,(H,26,27)/t17-,21+,23-/m1/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401333
PNG
(US10005762, Example 13)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(C2CCC3(CC3)CC2)c(C)cn1)C(O)=O
Show InChI InChI=1S/C22H34N2O3/c1-14(2)10-19(23)22(27,20(25)26)12-17-11-18(15(3)13-24-17)16-4-6-21(7-5-16)8-9-21/h11,13-14,16,19,27H,4-10,12,23H2,1-3H3,(H,25,26)/t19-,22+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401386
PNG
(US10005762, Example 66 | US10005762, Example 67)
Show SMILES CCC1Cc2ccnc(C[C@@](O)([C@@H](N)CC(C)C)C(O)=O)c2C1
Show InChI InChI=1S/C18H28N2O3/c1-4-12-8-13-5-6-20-15(14(13)9-12)10-18(23,17(21)22)16(19)7-11(2)3/h5-6,11-12,16,23H,4,7-10,19H2,1-3H3,(H,21,22)/t12?,16-,18+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401352
PNG
(US10005762, Example 32)
Show SMILES N[C@@H](COCCC1CC1)[C@](O)(Cc1nccc2C[C@H](CCC3CC3)Cc12)C(O)=O
Show InChI InChI=1S/C23H34N2O4/c24-21(14-29-10-8-16-3-4-16)23(28,22(26)27)13-20-19-12-17(6-5-15-1-2-15)11-18(19)7-9-25-20/h7,9,15-17,21,28H,1-6,8,10-14,24H2,(H,26,27)/t17-,21-,23+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401380
PNG
(US10005762, Example 60)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(COc2ccccc2)ccn1)C(O)=O
Show InChI InChI=1S/C20H26N2O4/c1-14(2)10-18(21)20(25,19(23)24)12-16-11-15(8-9-22-16)13-26-17-6-4-3-5-7-17/h3-9,11,14,18,25H,10,12-13,21H2,1-2H3,(H,23,24)/t18-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401378
PNG
(US10005762, Example 58)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(ccn1)C1=CCCCC1)C(O)=O
Show InChI InChI=1S/C19H28N2O3/c1-13(2)10-17(20)19(24,18(22)23)12-16-11-15(8-9-21-16)14-6-4-3-5-7-14/h6,8-9,11,13,17,24H,3-5,7,10,12,20H2,1-2H3,(H,22,23)/t17-,19+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401349
PNG
(US10005762, Example 29)
Show SMILES CC(C)(F)C[C@H](N)[C@](O)(Cc1nccc2C[C@@H](CCC3CC3)Cc12)C(O)=O
Show InChI InChI=1S/C21H31FN2O3/c1-20(2,22)12-18(23)21(27,19(25)26)11-17-16-10-14(6-5-13-3-4-13)9-15(16)7-8-24-17/h7-8,13-14,18,27H,3-6,9-12,23H2,1-2H3,(H,25,26)/t14-,18+,21-/m1/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401396
PNG
(US10005762, Example 76 | US10005762, Example 77)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1nccc2CC(CCc12)OCC1CCCCC1)C(O)=O
Show InChI InChI=1S/C24H38N2O4/c1-16(2)12-22(25)24(29,23(27)28)14-21-20-9-8-19(13-18(20)10-11-26-21)30-15-17-6-4-3-5-7-17/h10-11,16-17,19,22,29H,3-9,12-15,25H2,1-2H3,(H,27,28)/t19?,22-,24+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401345
PNG
(US10005762, Example 25)
Show SMILES Cc1cnc(C[C@@](O)([C@@H](N)COCCC2CC2)C(O)=O)cc1CCCC1CC1
Show InChI InChI=1S/C22H34N2O4/c1-15-13-24-19(11-18(15)4-2-3-16-5-6-16)12-22(27,21(25)26)20(23)14-28-10-9-17-7-8-17/h11,13,16-17,20,27H,2-10,12,14,23H2,1H3,(H,25,26)/t20-,22+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401366
PNG
(US10005762, Example 46)
Show SMILES CCCSC[C@H](N)[C@](O)(Cc1nccc2C[C@H](CCC3CC3)Cc12)C(O)=O
Show InChI InChI=1S/C21H32N2O3S/c1-2-9-27-13-19(22)21(26,20(24)25)12-18-17-11-15(6-5-14-3-4-14)10-16(17)7-8-23-18/h7-8,14-15,19,26H,2-6,9-13,22H2,1H3,(H,24,25)/t15-,19-,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401380
PNG
(US10005762, Example 60)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(COc2ccccc2)ccn1)C(O)=O
Show InChI InChI=1S/C20H26N2O4/c1-14(2)10-18(21)20(25,19(23)24)12-16-11-15(8-9-22-16)13-26-17-6-4-3-5-7-17/h3-9,11,14,18,25H,10,12-13,21H2,1-2H3,(H,23,24)/t18-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401386
PNG
(US10005762, Example 66 | US10005762, Example 67)
Show SMILES CCC1Cc2ccnc(C[C@@](O)([C@@H](N)CC(C)C)C(O)=O)c2C1
Show InChI InChI=1S/C18H28N2O3/c1-4-12-8-13-5-6-20-15(14(13)9-12)10-18(23,17(21)22)16(19)7-11(2)3/h5-6,11-12,16,23H,4,7-10,19H2,1-3H3,(H,21,22)/t12?,16-,18+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401376
PNG
(US10005762, Example 56)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1ncc(C)c(CCCC2CC2)c1C)C(O)=O
Show InChI InChI=1S/C21H34N2O3/c1-13(2)10-19(22)21(26,20(24)25)11-18-15(4)17(14(3)12-23-18)7-5-6-16-8-9-16/h12-13,16,19,26H,5-11,22H2,1-4H3,(H,24,25)/t19-,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401353
PNG
(US10005762, Example 33)
Show SMILES N[C@@H](COCCC1CC1)[C@](O)(Cc1nccc2C[C@@H](CCC3CC3)Cc12)C(O)=O
Show InChI InChI=1S/C23H34N2O4/c24-21(14-29-10-8-16-3-4-16)23(28,22(26)27)13-20-19-12-17(6-5-15-1-2-15)11-18(19)7-9-25-20/h7,9,15-17,21,28H,1-6,8,10-14,24H2,(H,26,27)/t17-,21+,23-/m1/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401341
PNG
(US10005762, Example 21)
Show SMILES CC(C)CSC[C@H](N)[C@](O)(Cc1cc(CCCC2CC2)ccn1)C(O)=O
Show InChI InChI=1S/C20H32N2O3S/c1-14(2)12-26-13-18(21)20(25,19(23)24)11-17-10-16(8-9-22-17)5-3-4-15-6-7-15/h8-10,14-15,18,25H,3-7,11-13,21H2,1-2H3,(H,23,24)/t18-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401342
PNG
(US10005762, Example 22)
Show SMILES N[C@@H](CSCCC1CC1)[C@](O)(Cc1cc(CCCC2CC2)ccn1)C(O)=O
Show InChI InChI=1S/C21H32N2O3S/c22-19(14-27-11-9-16-6-7-16)21(26,20(24)25)13-18-12-17(8-10-23-18)3-1-2-15-4-5-15/h8,10,12,15-16,19,26H,1-7,9,11,13-14,22H2,(H,24,25)/t19-,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401343
PNG
(US10005762, Example 23)
Show SMILES N[C@@H](CSCC1CCC1)[C@](O)(Cc1cc(CCCC2CC2)ccn1)C(O)=O
Show InChI InChI=1S/C21H32N2O3S/c22-19(14-27-13-17-5-2-6-17)21(26,20(24)25)12-18-11-16(9-10-23-18)4-1-3-15-7-8-15/h9-11,15,17,19,26H,1-8,12-14,22H2,(H,24,25)/t19-,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401324
PNG
(US10005762, Example 6(1) | US10005762, Example 6(2...)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(ccn1)C1CC1CC1CC1)C(O)=O
Show InChI InChI=1S/C20H30N2O3/c1-12(2)7-18(21)20(25,19(23)24)11-16-9-14(5-6-22-16)17-10-15(17)8-13-3-4-13/h5-6,9,12-13,15,17-18,25H,3-4,7-8,10-11,21H2,1-2H3,(H,23,24)/t15?,17?,18-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401328
PNG
(US10005762, Example 9)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1nccc2CC(CC3CC3)CCc12)C(O)=O
Show InChI InChI=1S/C21H32N2O3/c1-13(2)9-19(22)21(26,20(24)25)12-18-17-6-5-15(10-14-3-4-14)11-16(17)7-8-23-18/h7-8,13-15,19,26H,3-6,9-12,22H2,1-2H3,(H,24,25)/t15?,19-,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401358
PNG
(US10005762, Example 38)
Show SMILES CC(C)CC[C@H](N)[C@](O)(Cc1cc(CCCC2CC2)ccn1)C(O)=O
Show InChI InChI=1S/C20H32N2O3/c1-14(2)6-9-18(21)20(25,19(23)24)13-17-12-16(10-11-22-17)5-3-4-15-7-8-15/h10-12,14-15,18,25H,3-9,13,21H2,1-2H3,(H,23,24)/t18-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401359
PNG
(US10005762, Example 39)
Show SMILES N[C@@H](CCC1CCC1)[C@](O)(Cc1cc(CCCC2CC2)ccn1)C(O)=O
Show InChI InChI=1S/C21H32N2O3/c22-19(10-9-15-3-1-4-15)21(26,20(24)25)14-18-13-17(11-12-23-18)6-2-5-16-7-8-16/h11-13,15-16,19,26H,1-10,14,22H2,(H,24,25)/t19-,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401360
PNG
(US10005762, Example 40)
Show SMILES N[C@@H](CCC1CC1)[C@](O)(Cc1cc(CCCC2CC2)ccn1)C(O)=O
Show InChI InChI=1S/C20H30N2O3/c21-18(9-8-15-6-7-15)20(25,19(23)24)13-17-12-16(10-11-22-17)3-1-2-14-4-5-14/h10-12,14-15,18,25H,1-9,13,21H2,(H,23,24)/t18-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401399
PNG
(US10005762, Example 79)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(ccn1)C1CC1)C(O)=O
Show InChI InChI=1S/C16H24N2O3/c1-10(2)7-14(17)16(21,15(19)20)9-13-8-12(5-6-18-13)11-3-4-11/h5-6,8,10-11,14,21H,3-4,7,9,17H2,1-2H3,(H,19,20)/t14-,16+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401396
PNG
(US10005762, Example 76 | US10005762, Example 77)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1nccc2CC(CCc12)OCC1CCCCC1)C(O)=O
Show InChI InChI=1S/C24H38N2O4/c1-16(2)12-22(25)24(29,23(27)28)14-21-20-9-8-19(13-18(20)10-11-26-21)30-15-17-6-4-3-5-7-17/h10-11,16-17,19,22,29H,3-9,12-15,25H2,1-2H3,(H,27,28)/t19?,22-,24+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401341
PNG
(US10005762, Example 21)
Show SMILES CC(C)CSC[C@H](N)[C@](O)(Cc1cc(CCCC2CC2)ccn1)C(O)=O
Show InChI InChI=1S/C20H32N2O3S/c1-14(2)12-26-13-18(21)20(25,19(23)24)11-17-10-16(8-9-22-17)5-3-4-15-6-7-15/h8-10,14-15,18,25H,3-7,11-13,21H2,1-2H3,(H,23,24)/t18-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401352
PNG
(US10005762, Example 32)
Show SMILES N[C@@H](COCCC1CC1)[C@](O)(Cc1nccc2C[C@H](CCC3CC3)Cc12)C(O)=O
Show InChI InChI=1S/C23H34N2O4/c24-21(14-29-10-8-16-3-4-16)23(28,22(26)27)13-20-19-12-17(6-5-15-1-2-15)11-18(19)7-9-25-20/h7,9,15-17,21,28H,1-6,8,10-14,24H2,(H,26,27)/t17-,21-,23+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401343
PNG
(US10005762, Example 23)
Show SMILES N[C@@H](CSCC1CCC1)[C@](O)(Cc1cc(CCCC2CC2)ccn1)C(O)=O
Show InChI InChI=1S/C21H32N2O3S/c22-19(14-27-13-17-5-2-6-17)21(26,20(24)25)12-18-11-16(9-10-23-18)4-1-3-15-7-8-15/h9-11,15,17,19,26H,1-8,12-14,22H2,(H,24,25)/t19-,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401335
PNG
(US10005762, Example 15)
Show SMILES COc1cnc(C[C@@](O)([C@@H](N)CC(C)C)C(O)=O)cc1CCCC1CC1
Show InChI InChI=1S/C20H32N2O4/c1-13(2)9-18(21)20(25,19(23)24)11-16-10-15(17(26-3)12-22-16)6-4-5-14-7-8-14/h10,12-14,18,25H,4-9,11,21H2,1-3H3,(H,23,24)/t18-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401346
PNG
(US10005762, Example 26)
Show SMILES N[C@@H](COCCC1CC1)[C@](O)(Cc1cc(CCCC2CC2)ccn1)C(O)=O
Show InChI InChI=1S/C21H32N2O4/c22-19(14-27-11-9-16-6-7-16)21(26,20(24)25)13-18-12-17(8-10-23-18)3-1-2-15-4-5-15/h8,10,12,15-16,19,26H,1-7,9,11,13-14,22H2,(H,24,25)/t19-,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401390
PNG
(US10005762, Example 70)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(C2CCCC2)c(C)cn1)C(O)=O
Show InChI InChI=1S/C19H30N2O3/c1-12(2)8-17(20)19(24,18(22)23)10-15-9-16(13(3)11-21-15)14-6-4-5-7-14/h9,11-12,14,17,24H,4-8,10,20H2,1-3H3,(H,22,23)/t17-,19+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401376
PNG
(US10005762, Example 56)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1ncc(C)c(CCCC2CC2)c1C)C(O)=O
Show InChI InChI=1S/C21H34N2O3/c1-13(2)10-19(22)21(26,20(24)25)11-18-15(4)17(14(3)12-23-18)7-5-6-16-8-9-16/h12-13,16,19,26H,5-11,22H2,1-4H3,(H,24,25)/t19-,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401340
PNG
(US10005762, Example 20)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(CC(C)CC2CC2)ccn1)C(O)=O
Show InChI InChI=1S/C20H32N2O3/c1-13(2)8-18(21)20(25,19(23)24)12-17-11-16(6-7-22-17)10-14(3)9-15-4-5-15/h6-7,11,13-15,18,25H,4-5,8-10,12,21H2,1-3H3,(H,23,24)/t14?,18-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401318
PNG
(US10005762, Example 2)
Show SMILES N[C@@H](CSCC=C)[C@](O)(Cc1cc(CCCC2CC2)ccn1)C(O)=O
Show InChI InChI=1S/C19H28N2O3S/c1-2-10-25-13-17(20)19(24,18(22)23)12-16-11-15(8-9-21-16)5-3-4-14-6-7-14/h2,8-9,11,14,17,24H,1,3-7,10,12-13,20H2,(H,22,23)/t17-,19+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401334
PNG
(US10005762, Example 14)
Show SMILES CCCCCC#Cc1cc(C[C@@](O)([C@@H](N)CC(C)C)C(O)=O)ncc1C
Show InChI InChI=1S/C21H32N2O3/c1-5-6-7-8-9-10-17-12-18(23-14-16(17)4)13-21(26,20(24)25)19(22)11-15(2)3/h12,14-15,19,26H,5-8,11,13,22H2,1-4H3,(H,24,25)/t19-,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401386
PNG
(US10005762, Example 66 | US10005762, Example 67)
Show SMILES CCC1Cc2ccnc(C[C@@](O)([C@@H](N)CC(C)C)C(O)=O)c2C1
Show InChI InChI=1S/C18H28N2O3/c1-4-12-8-13-5-6-20-15(14(13)9-12)10-18(23,17(21)22)16(19)7-11(2)3/h5-6,11-12,16,23H,4,7-10,19H2,1-3H3,(H,21,22)/t12?,16-,18+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401334
PNG
(US10005762, Example 14)
Show SMILES CCCCCC#Cc1cc(C[C@@](O)([C@@H](N)CC(C)C)C(O)=O)ncc1C
Show InChI InChI=1S/C21H32N2O3/c1-5-6-7-8-9-10-17-12-18(23-14-16(17)4)13-21(26,20(24)25)19(22)11-15(2)3/h12,14-15,19,26H,5-8,11,13,22H2,1-4H3,(H,24,25)/t19-,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401348
PNG
(US10005762, Example 28)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1nccc2CC3(Cc12)CCCCC3)C(O)=O
Show InChI InChI=1S/C21H32N2O3/c1-14(2)10-18(22)21(26,19(24)25)13-17-16-12-20(7-4-3-5-8-20)11-15(16)6-9-23-17/h6,9,14,18,26H,3-5,7-8,10-13,22H2,1-2H3,(H,24,25)/t18-,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401337
PNG
(US10005762, Example 17)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc2[C@@H](CCC3CC3)CCc2cn1)C(O)=O
Show InChI InChI=1S/C21H32N2O3/c1-13(2)9-19(22)21(26,20(24)25)11-17-10-18-15(6-5-14-3-4-14)7-8-16(18)12-23-17/h10,12-15,19,26H,3-9,11,22H2,1-2H3,(H,24,25)/t15-,19-,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401379
PNG
(US10005762, Example 59)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(ccn1)C1=CCOCC1)C(O)=O
Show InChI InChI=1S/C18H26N2O4/c1-12(2)9-16(19)18(23,17(21)22)11-15-10-14(3-6-20-15)13-4-7-24-8-5-13/h3-4,6,10,12,16,23H,5,7-9,11,19H2,1-2H3,(H,21,22)/t16-,18+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401383
PNG
(US10005762, Example 63)
Show SMILES CCC1CCc2c(C1)ccnc2C[C@@](O)([C@@H](N)CC(C)C)C(O)=O
Show InChI InChI=1S/C19H30N2O3/c1-4-13-5-6-15-14(10-13)7-8-21-16(15)11-19(24,18(22)23)17(20)9-12(2)3/h7-8,12-13,17,24H,4-6,9-11,20H2,1-3H3,(H,22,23)/t13?,17-,19+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401377
PNG
(US10005762, Example 57)
Show SMILES COc1ccc(cc1)-c1ccnc(C[C@@](O)([C@@H](N)CC(C)C)C(O)=O)c1
Show InChI InChI=1S/C20H26N2O4/c1-13(2)10-18(21)20(25,19(23)24)12-16-11-15(8-9-22-16)14-4-6-17(26-3)7-5-14/h4-9,11,13,18,25H,10,12,21H2,1-3H3,(H,23,24)/t18-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401344
PNG
(US10005762, Example 24)
Show SMILES N[C@@H](CSC1CCC1)[C@](O)(Cc1cc(CCCC2CC2)ccn1)C(O)=O
Show InChI InChI=1S/C20H30N2O3S/c21-18(13-26-17-5-2-6-17)20(25,19(23)24)12-16-11-15(9-10-22-16)4-1-3-14-7-8-14/h9-11,14,17-18,25H,1-8,12-13,21H2,(H,23,24)/t18-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401400
PNG
(US10005762, Example 80)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1nccc2CC(CCc12)OCc1ccccc1)C(O)=O
Show InChI InChI=1S/C24H32N2O4/c1-16(2)12-22(25)24(29,23(27)28)14-21-20-9-8-19(13-18(20)10-11-26-21)30-15-17-6-4-3-5-7-17/h3-7,10-11,16,19,22,29H,8-9,12-15,25H2,1-2H3,(H,27,28)/t19?,22-,24+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401382
PNG
(US10005762, Example 62)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1nccc2CCCCc12)C(O)=O
Show InChI InChI=1S/C17H26N2O3/c1-11(2)9-15(18)17(22,16(20)21)10-14-13-6-4-3-5-12(13)7-8-19-14/h7-8,11,15,22H,3-6,9-10,18H2,1-2H3,(H,20,21)/t15-,17+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401385
PNG
(US10005762, Example 65)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1nccc2CCCc12)C(O)=O
Show InChI InChI=1S/C16H24N2O3/c1-10(2)8-14(17)16(21,15(19)20)9-13-12-5-3-4-11(12)6-7-18-13/h6-7,10,14,21H,3-5,8-9,17H2,1-2H3,(H,19,20)/t14-,16+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401324
PNG
(US10005762, Example 6(1) | US10005762, Example 6(2...)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(ccn1)C1CC1CC1CC1)C(O)=O
Show InChI InChI=1S/C20H30N2O3/c1-12(2)7-18(21)20(25,19(23)24)11-16-9-14(5-6-22-16)17-10-15(17)8-13-3-4-13/h5-6,9,12-13,15,17-18,25H,3-4,7-8,10-11,21H2,1-2H3,(H,23,24)/t15?,17?,18-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401398
PNG
(US10005762, Example 78)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(ccn1)C1CCOCC1)C(O)=O
Show InChI InChI=1S/C18H28N2O4/c1-12(2)9-16(19)18(23,17(21)22)11-15-10-14(3-6-20-15)13-4-7-24-8-5-13/h3,6,10,12-13,16,23H,4-5,7-9,11,19H2,1-2H3,(H,21,22)/t16-,18+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401399
PNG
(US10005762, Example 79)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(ccn1)C1CC1)C(O)=O
Show InChI InChI=1S/C16H24N2O3/c1-10(2)7-14(17)16(21,15(19)20)9-13-8-12(5-6-18-13)11-3-4-11/h5-6,8,10-11,14,21H,3-4,7,9,17H2,1-2H3,(H,19,20)/t14-,16+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401339
PNG
(US10005762, Example 19)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1nccc2CC3(CCCC3)CCc12)C(O)=O
Show InChI InChI=1S/C21H32N2O3/c1-14(2)11-18(22)21(26,19(24)25)13-17-16-5-9-20(7-3-4-8-20)12-15(16)6-10-23-17/h6,10,14,18,26H,3-5,7-9,11-13,22H2,1-2H3,(H,24,25)/t18-,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401329
PNG
(US10005762, Example 10(1) | US10005762, Example 10...)
Show SMILES CCC1CCc2ccnc(C[C@@](O)([C@@H](N)CC(C)C)C(O)=O)c12
Show InChI InChI=1S/C18H28N2O3/c1-4-12-5-6-13-7-8-20-14(16(12)13)10-18(23,17(21)22)15(19)9-11(2)3/h7-8,11-12,15,23H,4-6,9-10,19H2,1-3H3,(H,21,22)/t12?,15-,18+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401386
PNG
(US10005762, Example 66 | US10005762, Example 67)
Show SMILES CCC1Cc2ccnc(C[C@@](O)([C@@H](N)CC(C)C)C(O)=O)c2C1
Show InChI InChI=1S/C18H28N2O3/c1-4-12-8-13-5-6-20-15(14(13)9-12)10-18(23,17(21)22)16(19)7-11(2)3/h5-6,11-12,16,23H,4,7-10,19H2,1-3H3,(H,21,22)/t12?,16-,18+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401346
PNG
(US10005762, Example 26)
Show SMILES N[C@@H](COCCC1CC1)[C@](O)(Cc1cc(CCCC2CC2)ccn1)C(O)=O
Show InChI InChI=1S/C21H32N2O4/c22-19(14-27-11-9-16-6-7-16)21(26,20(24)25)13-18-12-17(8-10-23-18)3-1-2-15-4-5-15/h8,10,12,15-16,19,26H,1-7,9,11,13-14,22H2,(H,24,25)/t19-,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401335
PNG
(US10005762, Example 15)
Show SMILES COc1cnc(C[C@@](O)([C@@H](N)CC(C)C)C(O)=O)cc1CCCC1CC1
Show InChI InChI=1S/C20H32N2O4/c1-13(2)9-18(21)20(25,19(23)24)11-16-10-15(17(26-3)12-22-16)6-4-5-14-7-8-14/h10,12-14,18,25H,4-9,11,21H2,1-3H3,(H,23,24)/t18-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401326
PNG
(US10005762, Example 7)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1nccc(CCCC2CC2)c1C)C(O)=O
Show InChI InChI=1S/C20H32N2O3/c1-13(2)11-18(21)20(25,19(23)24)12-17-14(3)16(9-10-22-17)6-4-5-15-7-8-15/h9-10,13,15,18,25H,4-8,11-12,21H2,1-3H3,(H,23,24)/t18-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401385
PNG
(US10005762, Example 65)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1nccc2CCCc12)C(O)=O
Show InChI InChI=1S/C16H24N2O3/c1-10(2)8-14(17)16(21,15(19)20)9-13-12-5-3-4-11(12)6-7-18-13/h6-7,10,14,21H,3-5,8-9,17H2,1-2H3,(H,19,20)/t14-,16+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401382
PNG
(US10005762, Example 62)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1nccc2CCCCc12)C(O)=O
Show InChI InChI=1S/C17H26N2O3/c1-11(2)9-15(18)17(22,16(20)21)10-14-13-6-4-3-5-12(13)7-8-19-14/h7-8,11,15,22H,3-6,9-10,18H2,1-2H3,(H,20,21)/t15-,17+/m0/s1
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n/an/a 690n/an/an/an/an/an/a



Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401396
PNG
(US10005762, Example 76 | US10005762, Example 77)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1nccc2CC(CCc12)OCC1CCCCC1)C(O)=O
Show InChI InChI=1S/C24H38N2O4/c1-16(2)12-22(25)24(29,23(27)28)14-21-20-9-8-19(13-18(20)10-11-26-21)30-15-17-6-4-3-5-7-17/h10-11,16-17,19,22,29H,3-9,12-15,25H2,1-2H3,(H,27,28)/t19?,22-,24+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401329
PNG
(US10005762, Example 10(1) | US10005762, Example 10...)
Show SMILES CCC1CCc2ccnc(C[C@@](O)([C@@H](N)CC(C)C)C(O)=O)c12
Show InChI InChI=1S/C18H28N2O3/c1-4-12-5-6-13-7-8-20-14(16(12)13)10-18(23,17(21)22)15(19)9-11(2)3/h7-8,11-12,15,23H,4-6,9-10,19H2,1-3H3,(H,21,22)/t12?,15-,18+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%