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Patent code US10005769

Compile Data Set for Download or QSAR
Found 79 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401571
PNG
(US10005769, No. 35)
Show SMILES O=C(Nc1nc2cc(ccc2[nH]1)C(=O)NCC1CCCO1)c1csc(n1)-c1ccc2OCCc2c1
Show InChI InChI=1/C25H23N5O4S/c31-22(26-12-17-2-1-8-33-17)15-3-5-18-19(11-15)29-25(28-18)30-23(32)20-13-35-24(27-20)16-4-6-21-14(10-16)7-9-34-21/h3-6,10-11,13,17H,1-2,7-9,12H2,(H,26,31)(H2,28,29,30,32)
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US Patent
n/an/a<0.5n/an/an/an/an/an/a



4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401559
PNG
(US10005769, No. 23)
Show SMILES COCCNC(=O)c1ccc2[nH]c(NC(=O)c3csc(n3)-c3ccc4OCCc4c3)nc2c1
Show InChI InChI=1S/C23H21N5O4S/c1-31-9-7-24-20(29)14-2-4-16-17(11-14)27-23(26-16)28-21(30)18-12-33-22(25-18)15-3-5-19-13(10-15)6-8-32-19/h2-5,10-12H,6-9H2,1H3,(H,24,29)(H2,26,27,28,30)
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US Patent
n/an/a 0.699n/an/an/an/an/an/a



4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401558
PNG
(US10005769, No. 22)
Show SMILES O=C(Nc1nc2cc(ccc2[nH]1)C(=O)N1CCCC1)c1csc(n1)-c1ccc2OCCc2c1
Show InChI InChI=1S/C24H21N5O3S/c30-21(19-13-33-22(25-19)15-4-6-20-14(11-15)7-10-32-20)28-24-26-17-5-3-16(12-18(17)27-24)23(31)29-8-1-2-9-29/h3-6,11-13H,1-2,7-10H2,(H2,26,27,28,30)
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UniChem
US Patent
n/an/a 0.852n/an/an/an/an/an/a



4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401537
PNG
(US10005769, No. 1)
Show SMILES O=C(Nc1nc2cc(ccc2[nH]1)C#N)c1csc(n1)-c1ccc2OCCc2c1
Show InChI InChI=1S/C20H13N5O2S/c21-9-11-1-3-14-15(7-11)24-20(23-14)25-18(26)16-10-28-19(22-16)13-2-4-17-12(8-13)5-6-27-17/h1-4,7-8,10H,5-6H2,(H2,23,24,25,26)
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US Patent
n/an/a 1.38n/an/an/an/an/an/a



4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401539
PNG
(US10005769, No. 3)
Show SMILES CS(=O)(=O)c1ccc2[nH]c(NC(=O)c3csc(n3)-c3ccc4OCCc4c3)nc2c1
Show InChI InChI=1S/C20H16N4O4S2/c1-30(26,27)13-3-4-14-15(9-13)23-20(22-14)24-18(25)16-10-29-19(21-16)12-2-5-17-11(8-12)6-7-28-17/h2-5,8-10H,6-7H2,1H3,(H2,22,23,24,25)
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UniChem
US Patent
n/an/a 1.49n/an/an/an/an/an/a



4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401543
PNG
(US10005769, No. 7)
Show SMILES CN(C)C(=O)c1ccc2[nH]c(NC(=O)c3csc(n3)-c3ccc4OCCc4c3)nc2c1
Show InChI InChI=1S/C22H19N5O3S/c1-27(2)21(29)14-3-5-15-16(10-14)25-22(24-15)26-19(28)17-11-31-20(23-17)13-4-6-18-12(9-13)7-8-30-18/h3-6,9-11H,7-8H2,1-2H3,(H2,24,25,26,28)
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UniChem
US Patent
n/an/a 1.74n/an/an/an/an/an/a



4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401542
PNG
(US10005769, No. 6)
Show SMILES Clc1ccc2[nH]c(NC(=O)c3csc(n3)-c3ccc4OCCc4c3)nc2c1
Show InChI InChI=1S/C19H13ClN4O2S/c20-12-2-3-13-14(8-12)23-19(22-13)24-17(25)15-9-27-18(21-15)11-1-4-16-10(7-11)5-6-26-16/h1-4,7-9H,5-6H2,(H2,22,23,24,25)
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US Patent
n/an/a 1.90n/an/an/an/an/an/a



4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401578
PNG
(US10005769, No. 42)
Show SMILES O=C(Nc1nc(n[nH]1)-c1ccncc1)c1csc(n1)-c1ccc2OCCc2c1
Show InChI InChI=1S/C19H14N6O2S/c26-17(23-19-22-16(24-25-19)11-3-6-20-7-4-11)14-10-28-18(21-14)13-1-2-15-12(9-13)5-8-27-15/h1-4,6-7,9-10H,5,8H2,(H2,22,23,24,25,26)
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UniChem
US Patent
n/an/a 2.06n/an/an/an/an/an/a



4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401583
PNG
(US10005769, No. 47)
Show SMILES CCN1CCN(CC1)C(=O)c1ccc2[nH]c(NC(=O)c3csc(n3)-c3ccc4OCCc4c3)nc2c1
Show InChI InChI=1S/C26H26N6O3S/c1-2-31-8-10-32(11-9-31)25(34)18-3-5-19-20(14-18)29-26(28-19)30-23(33)21-15-36-24(27-21)17-4-6-22-16(13-17)7-12-35-22/h3-6,13-15H,2,7-12H2,1H3,(H2,28,29,30,33)
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n/an/a 2.17n/an/an/an/an/an/a



4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401581
PNG
(US10005769, No. 45)
Show SMILES O=C(Nc1nc(n[nH]1)-c1cccnc1)c1csc(n1)-c1ccc2OCCc2c1
Show InChI InChI=1S/C19H14N6O2S/c26-17(23-19-22-16(24-25-19)13-2-1-6-20-9-13)14-10-28-18(21-14)12-3-4-15-11(8-12)5-7-27-15/h1-4,6,8-10H,5,7H2,(H2,22,23,24,25,26)
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US Patent
n/an/a 2.81n/an/an/an/an/an/a



4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401544
PNG
(US10005769, No. 8)
Show SMILES O=C(Nc1nc2cc(ccc2[nH]1)C(=O)N1CCN(CC2CCCO2)CC1)c1csc(n1)-c1ccc2OCCc2c1
Show InChI InChI=1/C29H30N6O4S/c36-26(24-17-40-27(30-24)19-4-6-25-18(14-19)7-13-39-25)33-29-31-22-5-3-20(15-23(22)32-29)28(37)35-10-8-34(9-11-35)16-21-2-1-12-38-21/h3-6,14-15,17,21H,1-2,7-13,16H2,(H2,31,32,33,36)
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US Patent
n/an/a 3.11n/an/an/an/an/an/a



4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401561
PNG
(US10005769, No. 25)
Show SMILES O=C(Nc1nc(n[nH]1)C(=O)NC1CC1)c1csc(n1)-c1ccc2OCCc2c1
Show InChI InChI=1S/C18H16N6O3S/c25-15(22-18-21-14(23-24-18)16(26)19-11-2-3-11)12-8-28-17(20-12)10-1-4-13-9(7-10)5-6-27-13/h1,4,7-8,11H,2-3,5-6H2,(H,19,26)(H2,21,22,23,24,25)
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n/an/a 3.51n/an/an/an/an/an/a



4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401545
PNG
(US10005769, No. 9)
Show SMILES CCOC(=O)c1ccc2[nH]c(NC(=O)c3csc(n3)-c3ccc4OCCc4c3)nc2c1
Show InChI InChI=1S/C22H18N4O4S/c1-2-29-21(28)14-3-5-15-16(10-14)25-22(24-15)26-19(27)17-11-31-20(23-17)13-4-6-18-12(9-13)7-8-30-18/h3-6,9-11H,2,7-8H2,1H3,(H2,24,25,26,27)
UniProtKB/SwissProt

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US Patent
n/an/a 3.63n/an/an/an/an/an/a



4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401546
PNG
(US10005769, No. 10)
Show SMILES O=C(Nc1nc2cc(ccc2[nH]1)C(=O)N1CCOCC1)c1csc(n1)-c1ccc2OCCc2c1
Show InChI InChI=1S/C24H21N5O4S/c30-21(19-13-34-22(25-19)15-2-4-20-14(11-15)5-8-33-20)28-24-26-17-3-1-16(12-18(17)27-24)23(31)29-6-9-32-10-7-29/h1-4,11-13H,5-10H2,(H2,26,27,28,30)
UniProtKB/SwissProt

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US Patent
n/an/a 3.72n/an/an/an/an/an/a



4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401574
PNG
(US10005769, No. 38)
Show SMILES O=C(Nc1nc(SCC#N)n[nH]1)c1csc(n1)-c1ccc2OCCc2c1
Show InChI InChI=1S/C16H12N6O2S2/c17-4-6-25-16-20-15(21-22-16)19-13(23)11-8-26-14(18-11)10-1-2-12-9(7-10)3-5-24-12/h1-2,7-8H,3,5-6H2,(H2,19,20,21,22,23)
UniProtKB/SwissProt

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US Patent
n/an/a 3.97n/an/an/an/an/an/a



4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401584
PNG
(US10005769, No. 48)
Show SMILES O=C(Nc1nc2cc(ccc2[nH]1)C(=O)c1cccs1)c1csc(n1)-c1ccc2OCCc2c1
Show InChI InChI=1S/C24H16N4O3S2/c29-21(20-2-1-9-32-20)14-3-5-16-17(11-14)27-24(26-16)28-22(30)18-12-33-23(25-18)15-4-6-19-13(10-15)7-8-31-19/h1-6,9-12H,7-8H2,(H2,26,27,28,30)
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UniChem
US Patent
n/an/a 5.57n/an/an/an/an/an/a



4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401585
PNG
(US10005769, No. 49)
Show SMILES O=C(Nc1nc2cc(ccc2[nH]1)C(=O)c1ccc[nH]1)c1csc(n1)-c1ccc2OCCc2c1
Show InChI InChI=1S/C24H17N5O3S/c30-21(17-2-1-8-25-17)14-3-5-16-18(11-14)28-24(27-16)29-22(31)19-12-33-23(26-19)15-4-6-20-13(10-15)7-9-32-20/h1-6,8,10-12,25H,7,9H2,(H2,27,28,29,31)
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UniChem
US Patent
n/an/a 6.63n/an/an/an/an/an/a



4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401586
PNG
(US10005769, No. 50)
Show SMILES O=C(Nc1nc2ccccc2[nH]1)c1csc(n1)-c1ccc2OCCc2c1
Show InChI InChI=1S/C19H14N4O2S/c24-17(23-19-21-13-3-1-2-4-14(13)22-19)15-10-26-18(20-15)12-5-6-16-11(9-12)7-8-25-16/h1-6,9-10H,7-8H2,(H2,21,22,23,24)
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n/an/a 6.73n/an/an/an/an/an/a



4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401566
PNG
(US10005769, No. 30)
Show SMILES CCCSc1n[nH]c(NC(=O)c2csc(n2)-c2ccc3OCCc3c2)n1
Show InChI InChI=1S/C17H17N5O2S2/c1-2-7-25-17-20-16(21-22-17)19-14(23)12-9-26-15(18-12)11-3-4-13-10(8-11)5-6-24-13/h3-4,8-9H,2,5-7H2,1H3,(H2,19,20,21,22,23)
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US Patent
n/an/a 7.97n/an/an/an/an/an/a



4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401587
PNG
(US10005769, No. 51)
Show SMILES O=C(Nc1nc2ccc(cc2s1)C(=O)N1CCOCC1)c1csc(n1)-c1ccc2OCCc2c1
Show InChI InChI=1S/C24H20N4O4S2/c29-21(18-13-33-22(25-18)15-2-4-19-14(11-15)5-8-32-19)27-24-26-17-3-1-16(12-20(17)34-24)23(30)28-6-9-31-10-7-28/h1-4,11-13H,5-10H2,(H,26,27,29)
UniProtKB/SwissProt

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PC sid
UniChem
US Patent
n/an/a 9.17n/an/an/an/an/an/a



4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401555
PNG
(US10005769, No. 19)
Show SMILES CNC(=O)c1n[nH]c(NC(=O)c2csc(n2)-c2ccc3OCCc3c2)n1
Show InChI InChI=1S/C16H14N6O3S/c1-17-14(24)12-19-16(22-21-12)20-13(23)10-7-26-15(18-10)9-2-3-11-8(6-9)4-5-25-11/h2-3,6-7H,4-5H2,1H3,(H,17,24)(H2,19,20,21,22,23)
UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 9.68n/an/an/an/an/an/a



4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401575
PNG
(US10005769, No. 39)
Show SMILES C=CCSc1n[nH]c(NC(=O)c2csc(n2)-c2ccc3OCCc3c2)n1
Show InChI InChI=1S/C17H15N5O2S2/c1-2-7-25-17-20-16(21-22-17)19-14(23)12-9-26-15(18-12)11-3-4-13-10(8-11)5-6-24-13/h2-4,8-9H,1,5-7H2,(H2,19,20,21,22,23)
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n/an/a 11.9n/an/an/an/an/an/a



4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401588
PNG
(US10005769, No. 52)
Show SMILES O=C(Nc1nnc(s1)N1CCCCC1)c1csc(n1)-c1ccc2OCCc2c1
Show InChI InChI=1S/C19H19N5O2S2/c25-16(21-18-22-23-19(28-18)24-7-2-1-3-8-24)14-11-27-17(20-14)13-4-5-15-12(10-13)6-9-26-15/h4-5,10-11H,1-3,6-9H2,(H,21,22,25)
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n/an/a 12.6n/an/an/an/an/an/a



4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401540
PNG
(US10005769, No. 4)
Show SMILES COc1ccc2[nH]c(NC(=O)c3csc(n3)-c3ccc4OCCc4c3)nc2c1
Show InChI InChI=1S/C20H16N4O3S/c1-26-13-3-4-14-15(9-13)23-20(22-14)24-18(25)16-10-28-19(21-16)12-2-5-17-11(8-12)6-7-27-17/h2-5,8-10H,6-7H2,1H3,(H2,22,23,24,25)
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n/an/a 13.9n/an/an/an/an/an/a



4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401589
PNG
(US10005769, No. 53)
Show SMILES CCOC(=O)C1CCN(CC1)c1nnc(NC(=O)c2csc(n2)-c2ccc3OCCc3c2)s1
Show InChI InChI=1S/C22H23N5O4S2/c1-2-30-20(29)13-5-8-27(9-6-13)22-26-25-21(33-22)24-18(28)16-12-32-19(23-16)15-3-4-17-14(11-15)7-10-31-17/h3-4,11-13H,2,5-10H2,1H3,(H,24,25,28)
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n/an/a 14.4n/an/an/an/an/an/a



4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401582
PNG
(US10005769, No. 46)
Show SMILES O=C(Nc1nc(n[nH]1)-c1ccco1)c1csc(n1)-c1ccc2OCCc2c1
Show InChI InChI=1S/C18H13N5O3S/c24-16(21-18-20-15(22-23-18)14-2-1-6-25-14)12-9-27-17(19-12)11-3-4-13-10(8-11)5-7-26-13/h1-4,6,8-9H,5,7H2,(H2,20,21,22,23,24)
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n/an/a 15.3n/an/an/an/an/an/a



4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401576
PNG
(US10005769, No. 40)
Show SMILES O=C(Nc1nc2ccc(CN3CCOCC3)cc2s1)c1csc(n1)-c1ccc2OCCc2c1
Show InChI InChI=1S/C24H22N4O3S2/c29-22(19-14-32-23(25-19)17-2-4-20-16(12-17)5-8-31-20)27-24-26-18-3-1-15(11-21(18)33-24)13-28-6-9-30-10-7-28/h1-4,11-12,14H,5-10,13H2,(H,26,27,29)
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n/an/a 15.7n/an/an/an/an/an/a



4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401590
PNG
(US10005769, No. 54)
Show SMILES Cn1c(NC(=O)c2csc(n2)-c2ccc3OCCc3c2)nc2ccccc12
Show InChI InChI=1S/C20H16N4O2S/c1-24-16-5-3-2-4-14(16)22-20(24)23-18(25)15-11-27-19(21-15)13-6-7-17-12(10-13)8-9-26-17/h2-7,10-11H,8-9H2,1H3,(H,22,23,25)
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n/an/a 17.6n/an/an/an/an/an/a



4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401560
PNG
(US10005769, No. 24)
Show SMILES CC(C)Sc1n[nH]c(NC(=O)c2csc(n2)-c2ccc3OCCc3c2)n1
Show InChI InChI=1S/C17H17N5O2S2/c1-9(2)26-17-20-16(21-22-17)19-14(23)12-8-25-15(18-12)11-3-4-13-10(7-11)5-6-24-13/h3-4,7-9H,5-6H2,1-2H3,(H2,19,20,21,22,23)
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n/an/a 17.8n/an/an/an/an/an/a



4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401557
PNG
(US10005769, No. 21)
Show SMILES CSc1n[nH]c(NC(=O)c2csc(n2)-c2ccc3OCCc3c2)n1
Show InChI InChI=1S/C15H13N5O2S2/c1-23-15-18-14(19-20-15)17-12(21)10-7-24-13(16-10)9-2-3-11-8(6-9)4-5-22-11/h2-3,6-7H,4-5H2,1H3,(H2,17,18,19,20,21)
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4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401554
PNG
(US10005769, No. 18)
Show SMILES O=C(Nc1cc(ccn1)C#N)c1csc(n1)-c1ccc2OCCc2c1
Show InChI InChI=1S/C18H12N4O2S/c19-9-11-3-5-20-16(7-11)22-17(23)14-10-25-18(21-14)13-1-2-15-12(8-13)4-6-24-15/h1-3,5,7-8,10H,4,6H2,(H,20,22,23)
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n/an/a 19.5n/an/an/an/an/an/a



4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401577
PNG
(US10005769, No. 41)
Show SMILES CN1CCN(CC1)c1ccc2nc(NC(=O)c3csc(n3)-c3ccc4OCCc4c3)sc2c1
Show InChI InChI=1S/C24H23N5O2S2/c1-28-7-9-29(10-8-28)17-3-4-18-21(13-17)33-24(26-18)27-22(30)19-14-32-23(25-19)16-2-5-20-15(12-16)6-11-31-20/h2-5,12-14H,6-11H2,1H3,(H,26,27,30)
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n/an/a 19.5n/an/an/an/an/an/a



4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401591
PNG
(US10005769, No. 55)
Show SMILES CCOC(=O)c1c[nH]nc1NC(=O)c1csc(n1)-c1ccc2OCCc2c1
Show InChI InChI=1S/C18H16N4O4S/c1-2-25-18(24)12-8-19-22-15(12)21-16(23)13-9-27-17(20-13)11-3-4-14-10(7-11)5-6-26-14/h3-4,7-9H,2,5-6H2,1H3,(H2,19,21,22,23)
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4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401592
PNG
(US10005769, No. 56)
Show SMILES O=C(Nc1nnc(s1)N1CCOCC1)c1csc(n1)-c1ccc2OCCc2c1
Show InChI InChI=1S/C18H17N5O3S2/c24-15(20-17-21-22-18(28-17)23-4-7-25-8-5-23)13-10-27-16(19-13)12-1-2-14-11(9-12)3-6-26-14/h1-2,9-10H,3-8H2,(H,20,21,24)
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n/an/a 21.7n/an/an/an/an/an/a



4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401593
PNG
(US10005769, No. 57)
Show SMILES CN1CCN(CC1)c1nnc(NC(=O)c2csc(n2)-c2ccc3OCCc3c2)s1
Show InChI InChI=1S/C19H20N6O2S2/c1-24-5-7-25(8-6-24)19-23-22-18(29-19)21-16(26)14-11-28-17(20-14)13-2-3-15-12(10-13)4-9-27-15/h2-3,10-11H,4-9H2,1H3,(H,21,22,26)
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n/an/a 26.4n/an/an/an/an/an/a



4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401594
PNG
(US10005769, No. 58)
Show SMILES Cc1cnc(NC(=O)c2csc(n2)-c2ccc3OCCc3c2)s1
Show InChI InChI=1S/C16H13N3O2S2/c1-9-7-17-16(23-9)19-14(20)12-8-22-15(18-12)11-2-3-13-10(6-11)4-5-21-13/h2-3,6-8H,4-5H2,1H3,(H,17,19,20)
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4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401553
PNG
(US10005769, No. 17)
Show SMILES O=C(Nc1ccccn1)c1csc(n1)-c1ccc2OCCc2c1
Show InChI InChI=1S/C17H13N3O2S/c21-16(20-15-3-1-2-7-18-15)13-10-23-17(19-13)12-4-5-14-11(9-12)6-8-22-14/h1-5,7,9-10H,6,8H2,(H,18,20,21)
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n/an/a 29.4n/an/an/an/an/an/a



4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401550
PNG
(US10005769, No. 14)
Show SMILES FC(F)(F)Oc1ccc2[nH]c(NC(=O)c3csc(n3)-c3ccc4OCCc4c3)nc2c1
Show InChI InChI=1S/C20H13F3N4O3S/c21-20(22,23)30-12-2-3-13-14(8-12)26-19(25-13)27-17(28)15-9-31-18(24-15)11-1-4-16-10(7-11)5-6-29-16/h1-4,7-9H,5-6H2,(H2,25,26,27,28)
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4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401595
PNG
(US10005769, No. 59)
Show SMILES O=C(Nc1nnc(s1)-c1ccncc1)c1csc(n1)-c1ccc2OCCc2c1
Show InChI InChI=1S/C19H13N5O2S2/c25-16(22-19-24-23-18(28-19)11-3-6-20-7-4-11)14-10-27-17(21-14)13-1-2-15-12(9-13)5-8-26-15/h1-4,6-7,9-10H,5,8H2,(H,22,24,25)
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4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401570
PNG
(US10005769, No. 34)
Show SMILES CC(C)CSc1n[nH]c(NC(=O)c2csc(n2)-c2ccc3OCCc3c2)n1
Show InChI InChI=1S/C18H19N5O2S2/c1-10(2)8-27-18-21-17(22-23-18)20-15(24)13-9-26-16(19-13)12-3-4-14-11(7-12)5-6-25-14/h3-4,7,9-10H,5-6,8H2,1-2H3,(H2,20,21,22,23,24)
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4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401596
PNG
(US10005769, No. 60)
Show SMILES O=C(Nc1nc2cc(ccc2[nH]1)C(=O)c1ccccc1)c1csc(n1)-c1ccc2OCCc2c1
Show InChI InChI=1S/C26H18N4O3S/c31-23(15-4-2-1-3-5-15)17-6-8-19-20(13-17)29-26(28-19)30-24(32)21-14-34-25(27-21)18-7-9-22-16(12-18)10-11-33-22/h1-9,12-14H,10-11H2,(H2,28,29,30,32)
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4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401597
PNG
(US10005769, No. 61)
Show SMILES CCOC(=O)CSc1n[nH]c(NC(=O)c2csc(n2)-c2ccc3OCCc3c2)n1
Show InChI InChI=1S/C18H17N5O4S2/c1-2-26-14(24)9-29-18-21-17(22-23-18)20-15(25)12-8-28-16(19-12)11-3-4-13-10(7-11)5-6-27-13/h3-4,7-8H,2,5-6,9H2,1H3,(H2,20,21,22,23,25)
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4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401598
PNG
(US10005769, No. 62)
Show SMILES O=C(Nc1cc[nH]n1)c1csc(n1)-c1ccc2OCCc2c1
Show InChI InChI=1S/C15H12N4O2S/c20-14(18-13-3-5-16-19-13)11-8-22-15(17-11)10-1-2-12-9(7-10)4-6-21-12/h1-3,5,7-8H,4,6H2,(H2,16,18,19,20)
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n/an/a 42.4n/an/an/an/an/an/a



4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401564
PNG
(US10005769, No. 28)
Show SMILES O=C(Nc1nc(n[nH]1)C(=O)N1CCCC1)c1csc(n1)-c1ccc2OCCc2c1
Show InChI InChI=1S/C19H18N6O3S/c26-16(22-19-21-15(23-24-19)18(27)25-6-1-2-7-25)13-10-29-17(20-13)12-3-4-14-11(9-12)5-8-28-14/h3-4,9-10H,1-2,5-8H2,(H2,21,22,23,24,26)
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n/an/a 47.1n/an/an/an/an/an/a



4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401599
PNG
(US10005769, No. 63)
Show SMILES O=C(Nc1nc[nH]n1)c1csc(n1)-c1ccc2OCCc2c1
Show InChI InChI=1S/C14H11N5O2S/c20-12(18-14-15-7-16-19-14)10-6-22-13(17-10)9-1-2-11-8(5-9)3-4-21-11/h1-2,5-7H,3-4H2,(H2,15,16,18,19,20)
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n/an/a 47.1n/an/an/an/an/an/a



4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401538
PNG
(US10005769, No. 2)
Show SMILES Fc1cc2nc(NC(=O)c3csc(n3)-c3ccc4OCCc4c3)[nH]c2cc1Cl
Show InChI InChI=1S/C19H12ClFN4O2S/c20-11-6-13-14(7-12(11)21)24-19(23-13)25-17(26)15-8-28-18(22-15)10-1-2-16-9(5-10)3-4-27-16/h1-2,5-8H,3-4H2,(H2,23,24,25,26)
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n/an/a 48.2n/an/an/an/an/an/a



4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401600
PNG
(US10005769, No. 64)
Show SMILES COc1nc(NC(=O)c2csc(n2)-c2ccc3OCCc3c2)ns1
Show InChI InChI=1S/C15H12N4O3S2/c1-21-15-18-14(19-24-15)17-12(20)10-7-23-13(16-10)9-2-3-11-8(6-9)4-5-22-11/h2-3,6-7H,4-5H2,1H3,(H,17,19,20)
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n/an/a 48.3n/an/an/an/an/an/a



4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401601
PNG
(US10005769, No. 65)
Show SMILES O=C(Nc1nccs1)c1csc(n1)-c1ccc2OCCc2c1
Show InChI InChI=1S/C15H11N3O2S2/c19-13(18-15-16-4-6-21-15)11-8-22-14(17-11)10-1-2-12-9(7-10)3-5-20-12/h1-2,4,6-8H,3,5H2,(H,16,18,19)
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n/an/a 48.7n/an/an/an/an/an/a



4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401563
PNG
(US10005769, No. 27)
Show SMILES CN1CCN(CC1)C(=O)c1n[nH]c(NC(=O)c2csc(n2)-c2ccc3OCCc3c2)n1
Show InChI InChI=1S/C20H21N7O3S/c1-26-5-7-27(8-6-26)19(29)16-22-20(25-24-16)23-17(28)14-11-31-18(21-14)13-2-3-15-12(10-13)4-9-30-15/h2-3,10-11H,4-9H2,1H3,(H2,22,23,24,25,28)
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n/an/a 49.8n/an/an/an/an/an/a



4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401602
PNG
(US10005769, No. 66)
Show SMILES Cc1cc(NC(=O)c2csc(n2)-c2ccc3OCCc3c2)n[nH]1
Show InChI InChI=1S/C16H14N4O2S/c1-9-6-14(20-19-9)18-15(21)12-8-23-16(17-12)11-2-3-13-10(7-11)4-5-22-13/h2-3,6-8H,4-5H2,1H3,(H2,18,19,20,21)
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n/an/a 50.5n/an/an/an/an/an/a



4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401573
PNG
(US10005769, No. 37)
Show SMILES O=C(Nc1nc(SCCc2ccccc2)n[nH]1)c1csc(n1)-c1ccc2OCCc2c1
Show InChI InChI=1S/C22H19N5O2S2/c28-19(17-13-31-20(23-17)16-6-7-18-15(12-16)8-10-29-18)24-21-25-22(27-26-21)30-11-9-14-4-2-1-3-5-14/h1-7,12-13H,8-11H2,(H2,24,25,26,27,28)
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n/an/a 56n/an/an/an/an/an/a



4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401580
PNG
(US10005769, No. 44)
Show SMILES Cc1n[nH]c(NC(=O)c2csc(n2)-c2ccc3OCCc3c2)n1
Show InChI InChI=1S/C15H13N5O2S/c1-8-16-15(20-19-8)18-13(21)11-7-23-14(17-11)10-2-3-12-9(6-10)4-5-22-12/h2-3,6-7H,4-5H2,1H3,(H2,16,18,19,20,21)
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n/an/a 60.1n/an/an/an/an/an/a



4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401603
PNG
(US10005769, No. 67)
Show SMILES Brc1nnc(NC(=O)c2csc(n2)-c2ccc3OCCc3c2)s1
Show InChI InChI=1S/C14H9BrN4O2S2/c15-13-18-19-14(23-13)17-11(20)9-6-22-12(16-9)8-1-2-10-7(5-8)3-4-21-10/h1-2,5-6H,3-4H2,(H,17,19,20)
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n/an/a 65.9n/an/an/an/an/an/a



4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401547
PNG
(US10005769, No. 11)
Show SMILES O=C(Nc1ncc[nH]1)c1csc(n1)-c1ccc2OCCc2c1
Show InChI InChI=1S/C15H12N4O2S/c20-13(19-15-16-4-5-17-15)11-8-22-14(18-11)10-1-2-12-9(7-10)3-6-21-12/h1-2,4-5,7-8H,3,6H2,(H2,16,17,19,20)
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n/an/a 66.8n/an/an/an/an/an/a



4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401604
PNG
(US10005769, No. 68)
Show SMILES Fc1cccc(c1)-c1n[nH]c(NC(=O)c2csc(n2)-c2ccc3OCCc3c2)n1
Show InChI InChI=1S/C20H14FN5O2S/c21-14-3-1-2-12(9-14)17-23-20(26-25-17)24-18(27)15-10-29-19(22-15)13-4-5-16-11(8-13)6-7-28-16/h1-5,8-10H,6-7H2,(H2,23,24,25,26,27)
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n/an/a 67.1n/an/an/an/an/an/a



4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401567
PNG
(US10005769, No. 31)
Show SMILES OC(=O)c1n[nH]c(NC(=O)c2csc(n2)-c2ccc3OCCc3c2)n1
Show InChI InChI=1S/C15H11N5O4S/c21-12(18-15-17-11(14(22)23)19-20-15)9-6-25-13(16-9)8-1-2-10-7(5-8)3-4-24-10/h1-2,5-6H,3-4H2,(H,22,23)(H2,17,18,19,20,21)
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n/an/a 68.1n/an/an/an/an/an/a



4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401565
PNG
(US10005769, No. 29)
Show SMILES CN(C)C(=O)c1n[nH]c(NC(=O)c2csc(n2)-c2ccc3OCCc3c2)n1
Show InChI InChI=1S/C17H16N6O3S/c1-23(2)16(25)13-19-17(22-21-13)20-14(24)11-8-27-15(18-11)10-3-4-12-9(7-10)5-6-26-12/h3-4,7-8H,5-6H2,1-2H3,(H2,19,20,21,22,24)
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n/an/a 72n/an/an/an/an/an/a



4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401605
PNG
(US10005769, No. 69)
Show SMILES Cc1nsc(NC(=O)c2csc(n2)-c2ccc3OCCc3c2)n1
Show InChI InChI=1S/C15H12N4O2S2/c1-8-16-15(23-19-8)18-13(20)11-7-22-14(17-11)10-2-3-12-9(6-10)4-5-21-12/h2-3,6-7H,4-5H2,1H3,(H,16,18,19,20)
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n/an/a 72.6n/an/an/an/an/an/a



4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401606
PNG
(US10005769, No. 70)
Show SMILES Nc1nc(NC(=O)c2csc(n2)-c2ccc3OCCc3c2)ns1
Show InChI InChI=1S/C14H11N5O2S2/c15-13-18-14(19-23-13)17-11(20)9-6-22-12(16-9)8-1-2-10-7(5-8)3-4-21-10/h1-2,5-6H,3-4H2,(H3,15,17,18,19,20)
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n/an/a 73.4n/an/an/an/an/an/a



4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401607
PNG
(US10005769, No. 71)
Show SMILES O=C(Nc1nncs1)c1csc(n1)-c1ccc2OCCc2c1
Show InChI InChI=1S/C14H10N4O2S2/c19-12(17-14-18-15-7-22-14)10-6-21-13(16-10)9-1-2-11-8(5-9)3-4-20-11/h1-2,5-7H,3-4H2,(H,17,18,19)
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n/an/a 76.6n/an/an/an/an/an/a



4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401562
PNG
(US10005769, No. 26)
Show SMILES O=C(Nc1nc(n[nH]1)C(=O)N1CCOCC1)c1csc(n1)-c1ccc2OCCc2c1
Show InChI InChI=1S/C19H18N6O4S/c26-16(22-19-21-15(23-24-19)18(27)25-4-7-28-8-5-25)13-10-30-17(20-13)12-1-2-14-11(9-12)3-6-29-14/h1-2,9-10H,3-8H2,(H2,21,22,23,24,26)
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4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401541
PNG
(US10005769, No. 5)
Show SMILES FC(F)(F)c1ccc2[nH]c(NC(=O)c3csc(n3)-c3ccc4OCCc4c3)nc2c1
Show InChI InChI=1S/C20H13F3N4O2S/c21-20(22,23)12-2-3-13-14(8-12)26-19(25-13)27-17(28)15-9-30-18(24-15)11-1-4-16-10(7-11)5-6-29-16/h1-4,7-9H,5-6H2,(H2,25,26,27,28)
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n/an/a 90.9n/an/an/an/an/an/a



4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401551
PNG
(US10005769, No. 15 | US10005769, No. 20)
Show SMILES COC(=O)c1n[nH]c(NC(=O)c2csc(n2)-c2ccc3OCCc3c2)n1
Show InChI InChI=1S/C16H13N5O4S/c1-24-15(23)12-18-16(21-20-12)19-13(22)10-7-26-14(17-10)9-2-3-11-8(6-9)4-5-25-11/h2-3,6-7H,4-5H2,1H3,(H2,18,19,20,21,22)
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4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401608
PNG
(US10005769, No. 72)
Show SMILES Cc1csc(NC(=O)c2csc(n2)-c2ccc3OCCc3c2)n1
Show InChI InChI=1S/C16H13N3O2S2/c1-9-7-23-16(17-9)19-14(20)12-8-22-15(18-12)11-2-3-13-10(6-11)4-5-21-13/h2-3,6-8H,4-5H2,1H3,(H,17,19,20)
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4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401549
PNG
(US10005769, No. 13)
Show SMILES COc1cccc(c1)-c1c[nH]c(NC(=O)c2csc(n2)-c2ccc3OCCc3c2)n1
Show InChI InChI=1S/C22H18N4O3S/c1-28-16-4-2-3-13(10-16)17-11-23-22(25-17)26-20(27)18-12-30-21(24-18)15-5-6-19-14(9-15)7-8-29-19/h2-6,9-12H,7-8H2,1H3,(H2,23,25,26,27)
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n/an/a 111n/an/an/an/an/an/a



4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401572
PNG
(US10005769, No. 36)
Show SMILES O=C(Nc1nc(CCc2ccccc2)n[nH]1)c1csc(n1)-c1ccc2OCCc2c1
Show InChI InChI=1S/C22H19N5O2S/c28-20(25-22-24-19(26-27-22)9-6-14-4-2-1-3-5-14)17-13-30-21(23-17)16-7-8-18-15(12-16)10-11-29-18/h1-5,7-8,12-13H,6,9-11H2,(H2,24,25,26,27,28)
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n/an/a 112n/an/an/an/an/an/a



4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401609
PNG
(US10005769, No. 73)
Show SMILES O=C(Nc1ncns1)c1csc(n1)-c1ccc2OCCc2c1
Show InChI InChI=1S/C14H10N4O2S2/c19-12(18-14-15-7-16-22-14)10-6-21-13(17-10)9-1-2-11-8(5-9)3-4-20-11/h1-2,5-7H,3-4H2,(H,15,16,18,19)
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n/an/a 114n/an/an/an/an/an/a



4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401610
PNG
(US10005769, No. 74)
Show SMILES Cc1nc(NC(=O)c2csc(n2)-c2ccc3OCCc3c2)sc1C
Show InChI InChI=1S/C17H15N3O2S2/c1-9-10(2)24-17(18-9)20-15(21)13-8-23-16(19-13)12-3-4-14-11(7-12)5-6-22-14/h3-4,7-8H,5-6H2,1-2H3,(H,18,20,21)
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n/an/a 125n/an/an/an/an/an/a



4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401611
PNG
(US10005769, No. 75)
Show SMILES O=C(Nc1nc2ccccc2s1)c1csc(n1)-c1ccc2OCCc2c1
Show InChI InChI=1S/C19H13N3O2S2/c23-17(22-19-21-13-3-1-2-4-16(13)26-19)14-10-25-18(20-14)12-5-6-15-11(9-12)7-8-24-15/h1-6,9-10H,7-8H2,(H,21,22,23)
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n/an/a 135n/an/an/an/an/an/a



4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401551
PNG
(US10005769, No. 15 | US10005769, No. 20)
Show SMILES COC(=O)c1n[nH]c(NC(=O)c2csc(n2)-c2ccc3OCCc3c2)n1
Show InChI InChI=1S/C16H13N5O4S/c1-24-15(23)12-18-16(21-20-12)19-13(22)10-7-26-14(17-10)9-2-3-11-8(6-9)4-5-25-11/h2-3,6-7H,4-5H2,1H3,(H2,18,19,20,21,22)
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n/an/a 152n/an/an/an/an/an/a



4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401548
PNG
(US10005769, No. 12)
Show SMILES FC(F)(F)c1cccc2[nH]c(NC(=O)c3csc(n3)-c3ccc4OCCc4c3)nc12
Show InChI InChI=1S/C20H13F3N4O2S/c21-20(22,23)12-2-1-3-13-16(12)26-19(25-13)27-17(28)14-9-30-18(24-14)11-4-5-15-10(8-11)6-7-29-15/h1-5,8-9H,6-7H2,(H2,25,26,27,28)
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n/an/a 156n/an/an/an/an/an/a



4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401552
PNG
(US10005769, No. 16)
Show SMILES Oc1cccnc1NC(=O)c1csc(n1)-c1ccc2OCCc2c1
Show InChI InChI=1S/C17H13N3O3S/c21-13-2-1-6-18-15(13)20-16(22)12-9-24-17(19-12)11-3-4-14-10(8-11)5-7-23-14/h1-4,6,8-9,21H,5,7H2,(H,18,20,22)
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n/an/a 177n/an/an/an/an/an/a



4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401612
PNG
(US10005769, No. 76)
Show SMILES CC(=O)c1csc(NC(=O)c2csc(n2)-c2ccc3OCCc3c2)n1
Show InChI InChI=1S/C17H13N3O3S2/c1-9(21)12-7-25-17(19-12)20-15(22)13-8-24-16(18-13)11-2-3-14-10(6-11)4-5-23-14/h2-3,6-8H,4-5H2,1H3,(H,19,20,22)
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n/an/a 185n/an/an/an/an/an/a



4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401569
PNG
(US10005769, No. 33)
Show SMILES Clc1ccc(CSc2n[nH]c(NC(=O)c3csc(n3)-c3ccc4OCCc4c3)n2)cc1
Show InChI InChI=1S/C21H16ClN5O2S2/c22-15-4-1-12(2-5-15)10-31-21-25-20(26-27-21)24-18(28)16-11-30-19(23-16)14-3-6-17-13(9-14)7-8-29-17/h1-6,9,11H,7-8,10H2,(H2,24,25,26,27,28)
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n/an/a 337n/an/an/an/an/an/a



4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401614
PNG
(US10005769, No. 78)
Show SMILES CCOC(=O)c1csc(NC(=O)c2csc(n2)-c2ccc3OCCc3c2)n1
Show InChI InChI=1S/C18H15N3O4S2/c1-2-24-17(23)13-9-27-18(20-13)21-15(22)12-8-26-16(19-12)11-3-4-14-10(7-11)5-6-25-14/h3-4,7-9H,2,5-6H2,1H3,(H,20,21,22)
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n/an/a 410n/an/an/an/an/an/a



4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401613
PNG
(US10005769, No. 77)
Show SMILES CSc1nc(NC(=O)c2csc(n2)-c2ccc3OCCc3c2)ns1
Show InChI InChI=1S/C15H12N4O2S3/c1-22-15-18-14(19-24-15)17-12(20)10-7-23-13(16-10)9-2-3-11-8(6-9)4-5-21-11/h2-3,6-7H,4-5H2,1H3,(H,17,19,20)
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n/an/a 420n/an/an/an/an/an/a



4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401579
PNG
(US10005769, No. 43)
Show SMILES CS(=O)(=O)c1n[nH]c(NC(=O)c2csc(n2)-c2ccc3OCCc3c2)n1
Show InChI InChI=1S/C15H13N5O4S2/c1-26(22,23)15-18-14(19-20-15)17-12(21)10-7-25-13(16-10)9-2-3-11-8(6-9)4-5-24-11/h2-3,6-7H,4-5H2,1H3,(H2,17,18,19,20,21)
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n/an/a 535n/an/an/an/an/an/a



4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401615
PNG
(US10005769, No. 79)
Show SMILES O=C(Nc1ncco1)c1csc(n1)-c1ccc2OCCc2c1
Show InChI InChI=1S/C15H11N3O3S/c19-13(18-15-16-4-6-21-15)11-8-22-14(17-11)10-1-2-12-9(7-10)3-5-20-12/h1-2,4,6-8H,3,5H2,(H,16,18,19)
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n/an/a 766n/an/an/an/an/an/a



4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM401568
PNG
(US10005769, No. 32)
Show SMILES O=C(Nc1nc(SCc2ccccc2)n[nH]1)c1csc(n1)-c1ccc2OCCc2c1
Show InChI InChI=1S/C21H17N5O2S2/c27-18(23-20-24-21(26-25-20)30-11-13-4-2-1-3-5-13)16-12-29-19(22-16)15-6-7-17-14(10-15)8-9-28-17/h1-7,10,12H,8-9,11H2,(H2,23,24,25,26,27)
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n/an/a 1.35E+3n/an/an/an/an/an/a



4SC AG

US Patent


Assay Description
The substrate DYRKtide (synthetic peptide RRRFRPASPLRGPPK) was dissolved in freshly prepared Base Reaction Buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2,...


US Patent US10005769 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%