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Patent code US10005783

Compile Data Set for Download or QSAR
Found 105 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136646
PNG
(US10005783, 63 | US10047097, 63 | US8865698, 63 | ...)
Show SMILES Cc1cccnc1C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C23H20F2N6O/c1-14-4-2-9-26-21(14)23(32)28-18-13-27-31-11-8-20(29-22(18)31)30-10-3-5-19(30)16-12-15(24)6-7-17(16)25/h2,4,6-9,11-13,19H,3,5,10H2,1H3,(H,28,32)/t19-/s2
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US Patent
n/an/a 1.70n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136642
PNG
(US10005783, 59 | US10047097, 59 | US8865698, 59 | ...)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccn2ncc(NC(=O)c3ccccn3)c2n1
Show InChI InChI=1/C22H18F2N6O/c23-14-6-7-16(24)15(12-14)19-5-3-10-29(19)20-8-11-30-21(28-20)18(13-26-30)27-22(31)17-4-1-2-9-25-17/h1-2,4,6-9,11-13,19H,3,5,10H2,(H,27,31)/t19-/s2
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US Patent
n/an/a 1.70n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM401674
PNG
(US10005783, 57)
Show SMILES NC(=O)c1nccnc1C1=C2N=CC=CN2N(C1)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C21H19F2N7O/c22-13-4-5-16(23)14(11-13)17-3-1-9-28(17)30-12-15(21-27-6-2-10-29(21)30)18-19(20(24)31)26-8-7-25-18/h2,4-8,10-11,17H,1,3,9,12H2,(H2,24,31)/t17-/m1/s1
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US Patent
n/an/a 2.20n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136650
PNG
(US10005783, 67 | US10047097, 67 | US8865698, 67 | ...)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccn2ncc(NC(=O)c3ncccn3)c2n1
Show InChI InChI=1/C21H17F2N7O/c22-13-4-5-15(23)14(11-13)17-3-1-9-29(17)18-6-10-30-20(28-18)16(12-26-30)27-21(31)19-24-7-2-8-25-19/h2,4-8,10-12,17H,1,3,9H2,(H,27,31)/t17-/s2
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n/an/a 3n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136638
PNG
(US10005783, 55 | US10047097, 55 | US8865698, 55 | ...)
Show SMILES CC(C)Nc1nc(cs1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C23H23F2N7OS/c1-13(2)27-23-29-18(12-34-23)22(33)28-17-11-26-32-9-7-20(30-21(17)32)31-8-3-4-19(31)15-10-14(24)5-6-16(15)25/h5-7,9-13,19H,3-4,8H2,1-2H3,(H,27,29)(H,28,33)/t19-/s2
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US Patent
n/an/a 3.10n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136641
PNG
(US10005783, 58 | US10047097, 58 | US8865698, 58 | ...)
Show SMILES Cc1cnc(cn1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C22H19F2N7O/c1-13-10-26-18(11-25-13)22(32)28-17-12-27-31-8-6-20(29-21(17)31)30-7-2-3-19(30)15-9-14(23)4-5-16(15)24/h4-6,8-12,19H,2-3,7H2,1H3,(H,28,32)/t19-/s2
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US Patent
n/an/a 3.10n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136667
PNG
(US10005783, 84 | US10047097, 84 | US8865698, 84 | ...)
Show SMILES O[C@H]1CCN(C1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1C(F)(F)F
Show InChI InChI=1/C22H22F4N6O2/c23-13-3-4-16(22(24,25)26)15(10-13)18-2-1-7-31(18)19-6-9-32-20(29-19)17(11-27-32)28-21(34)30-8-5-14(33)12-30/h3-4,6,9-11,14,18,33H,1-2,5,7-8,12H2,(H,28,34)/t14-,18+/s2
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US Patent
n/an/a 3.20n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136654
PNG
(US10005783, 71 | US10047097, 71 | US8865698, 71 | ...)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccn2ncc(NC(=O)c3cccc(Cl)n3)c2n1
Show InChI InChI=1/C22H17ClF2N6O/c23-19-5-1-3-16(27-19)22(32)28-17-12-26-31-10-8-20(29-21(17)31)30-9-2-4-18(30)14-11-13(24)6-7-15(14)25/h1,3,5-8,10-12,18H,2,4,9H2,(H,28,32)/t18-/s2
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n/an/a 3.5n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136651
PNG
(US10005783, 68 | US10047097, 68 | US8865698, 68 | ...)
Show SMILES Fc1cccc(c1)[C@H]1CCCN1c1ccn2ncc(NC(=O)c3ccccn3)c2n1
Show InChI InChI=1/C22H19FN6O/c23-16-6-3-5-15(13-16)19-8-4-11-28(19)20-9-12-29-21(27-20)18(14-25-29)26-22(30)17-7-1-2-10-24-17/h1-3,5-7,9-10,12-14,19H,4,8,11H2,(H,26,30)/t19-/s2
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US Patent
n/an/a 4n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136644
PNG
(US10005783, 61 | US10047097, 61 | US8865698, 61 | ...)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccn2ncc(NC(=O)c3ccc(Cl)cn3)c2n1
Show InChI InChI=1/C22H17ClF2N6O/c23-13-3-6-17(26-11-13)22(32)28-18-12-27-31-9-7-20(29-21(18)31)30-8-1-2-19(30)15-10-14(24)4-5-16(15)25/h3-7,9-12,19H,1-2,8H2,(H,28,32)/t19-/s2
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US Patent
n/an/a 4n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136645
PNG
(US10005783, 62 | US10047097, 62 | US8865698, 62 | ...)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccn2ncc(NC(=O)c3cc(Cl)ccn3)c2n1
Show InChI InChI=1/C22H17ClF2N6O/c23-13-5-7-26-17(10-13)22(32)28-18-12-27-31-9-6-20(29-21(18)31)30-8-1-2-19(30)15-11-14(24)3-4-16(15)25/h3-7,9-12,19H,1-2,8H2,(H,28,32)/t19-/s2
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US Patent
n/an/a 4n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136624
PNG
(US10005783, 41 | US10047097, 41 | US8865698, 41 | ...)
Show SMILES O[C@@H]1CCN(C1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1Cl
Show InChI InChI=1/C21H22ClFN6O2/c22-16-4-3-13(23)10-15(16)18-2-1-7-28(18)19-6-9-29-20(26-19)17(11-24-29)25-21(31)27-8-5-14(30)12-27/h3-4,6,9-11,14,18,30H,1-2,5,7-8,12H2,(H,25,31)/t14-,18-/s2
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US Patent
n/an/a 4.10n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136635
PNG
(US10005783, 52 | US10047097, 52 | US8865698, 52 | ...)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccn2ncc(NC(=O)C3(CC3)C#N)c2n1
Show InChI InChI=1/C21H18F2N6O/c22-13-3-4-15(23)14(10-13)17-2-1-8-28(17)18-5-9-29-19(27-18)16(11-25-29)26-20(30)21(12-24)6-7-21/h3-5,9-11,17H,1-2,6-8H2,(H,26,30)/t17-/s2
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US Patent
n/an/a 4.20n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136643
PNG
(US10005783, 60 | US10047097, 60 | US8865698, 60 | ...)
Show SMILES Cc1cccc(n1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C23H20F2N6O/c1-14-4-2-5-18(27-14)23(32)28-19-13-26-31-11-9-21(29-22(19)31)30-10-3-6-20(30)16-12-15(24)7-8-17(16)25/h2,4-5,7-9,11-13,20H,3,6,10H2,1H3,(H,28,32)/t20-/s2
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US Patent
n/an/a 4.20n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136601
PNG
(US10005783, 18 | US10047097, 18 | US8865698, 18 | ...)
Show SMILES Fc1ccc(NC(=O)Nc2cnn3ccc(nc23)N2CCC[C@@H]2c2cc(F)ccc2F)cc1
Show InChI InChI=1/C23H19F3N6O/c24-14-3-6-16(7-4-14)28-23(33)29-19-13-27-32-11-9-21(30-22(19)32)31-10-1-2-20(31)17-12-15(25)5-8-18(17)26/h3-9,11-13,20H,1-2,10H2,(H2,28,29,33)/t20-/s2
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US Patent
n/an/a 4.60n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136682
PNG
(US10005783, 99 | US10047097, 99 | US8865698, 99 | ...)
Show SMILES NC(=O)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C18H16F2N6O2/c19-10-3-4-12(20)11(8-10)14-2-1-6-25(14)15-5-7-26-17(24-15)13(9-22-26)23-18(28)16(21)27/h3-5,7-9,14H,1-2,6H2,(H2,21,27)(H,23,28)/t14-/s2
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n/an/a 4.65n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136616
PNG
(US10005783, 33 | US10047097, 33 | US8865698, 33 | ...)
Show SMILES COC(=O)C1(CC1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C22H21F2N5O3/c1-32-21(31)22(7-8-22)20(30)26-16-12-25-29-10-6-18(27-19(16)29)28-9-2-3-17(28)14-11-13(23)4-5-15(14)24/h4-6,10-12,17H,2-3,7-9H2,1H3,(H,26,30)/t17-/s2
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US Patent
n/an/a 4.70n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136688
PNG
(US10005783, 105 | US10047097, 105 | US8865698, 105...)
Show SMILES OC(=O)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C18H15F2N5O3/c19-10-3-4-12(20)11(8-10)14-2-1-6-24(14)15-5-7-25-16(23-15)13(9-21-25)22-17(26)18(27)28/h3-5,7-9,14H,1-2,6H2,(H,22,26)(H,27,28)/t14-/s2
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US Patent
n/an/a 4.70n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136603
PNG
(US10005783, 20 | US10047097, 20 | US8865698, 20 | ...)
Show SMILES COc1ccc(NC(=O)Nc2cnn3ccc(nc23)N2CCC[C@@H]2c2cc(F)ccc2F)cc1
Show InChI InChI=1/C24H22F2N6O2/c1-34-17-7-5-16(6-8-17)28-24(33)29-20-14-27-32-12-10-22(30-23(20)32)31-11-2-3-21(31)18-13-15(25)4-9-19(18)26/h4-10,12-14,21H,2-3,11H2,1H3,(H2,28,29,33)/t21-/s2
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US Patent
n/an/a 4.80n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136587
PNG
(US10005783, 4 | US10047097, 4 | US8865698, 4 | US9...)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccn2ncc(NC(=O)Nc3ccccc3)c2n1
Show InChI InChI=1/C23H20F2N6O/c24-15-8-9-18(25)17(13-15)20-7-4-11-30(20)21-10-12-31-22(29-21)19(14-26-31)28-23(32)27-16-5-2-1-3-6-16/h1-3,5-6,8-10,12-14,20H,4,7,11H2,(H2,27,28,32)/t20-/s2
PDB
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US Patent
n/an/a 5n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136634
PNG
(US10005783, 51 | US10047097, 51 | US8865698, 51 | ...)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccn2ncc(NC(=O)C3(CC3)C(F)(F)F)c2n1
Show InChI InChI=1/C21H18F5N5O/c22-12-3-4-14(23)13(10-12)16-2-1-8-30(16)17-5-9-31-18(29-17)15(11-27-31)28-19(32)20(6-7-20)21(24,25)26/h3-5,9-11,16H,1-2,6-8H2,(H,28,32)/t16-/s2
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n/an/a 5.20n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136662
PNG
(US10005783, 79 | US10047097, 79 | US8865698, 79 | ...)
Show SMILES COc1ncccc1C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cccc(F)c1
Show InChI InChI=1/C23H21FN6O2/c1-32-23-17(7-3-10-25-23)22(31)27-18-14-26-30-12-9-20(28-21(18)30)29-11-4-8-19(29)15-5-2-6-16(24)13-15/h2-3,5-7,9-10,12-14,19H,4,8,11H2,1H3,(H,27,31)/t19-/s2
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n/an/a 5.70n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136668
PNG
(US10005783, 85 | US10047097, 85 | US8865698, 85 | ...)
Show SMILES O[C@@H]1CCN(C1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1C(F)(F)F
Show InChI InChI=1/C22H22F4N6O2/c23-13-3-4-16(22(24,25)26)15(10-13)18-2-1-7-31(18)19-6-9-32-20(29-19)17(11-27-32)28-21(34)30-8-5-14(33)12-30/h3-4,6,9-11,14,18,33H,1-2,5,7-8,12H2,(H,28,34)/t14-,18-/s2
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n/an/a 5.70n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136652
PNG
(US10005783, 69 | US10047097, 69 | US8865698, 69 | ...)
Show SMILES Cc1cccnc1C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cccc(F)c1
Show InChI InChI=1/C23H21FN6O/c1-15-5-3-10-25-21(15)23(31)27-18-14-26-30-12-9-20(28-22(18)30)29-11-4-8-19(29)16-6-2-7-17(24)13-16/h2-3,5-7,9-10,12-14,19H,4,8,11H2,1H3,(H,27,31)/t19-/s2
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n/an/a 6.20n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136628
PNG
(US10005783, 45 | US10047097, 45 | US8865698, 45 | ...)
Show SMILES CC(C)(C)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C21H23F2N5O/c1-21(2,3)20(29)25-16-12-24-28-10-8-18(26-19(16)28)27-9-4-5-17(27)14-11-13(22)6-7-15(14)23/h6-8,10-12,17H,4-5,9H2,1-3H3,(H,25,29)/t17-/s2
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n/an/a 6.30n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136665
PNG
(US10005783, 82 | US10047097, 82 | US8865698, 82 | ...)
Show SMILES Cc1cnc(cn1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cccc(F)c1
Show InChI InChI=1/C22H20FN7O/c1-14-11-25-18(12-24-14)22(31)27-17-13-26-30-9-7-20(28-21(17)30)29-8-3-6-19(29)15-4-2-5-16(23)10-15/h2,4-5,7,9-13,19H,3,6,8H2,1H3,(H,27,31)/t19-/s2
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n/an/a 6.60n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136658
PNG
(US10005783, 75 | US10047097, 75 | US8865698, 75 | ...)
Show SMILES COc1cccc(n1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cccc(F)c1
Show InChI InChI=1/C23H21FN6O2/c1-32-21-9-3-7-17(26-21)23(31)27-18-14-25-30-12-10-20(28-22(18)30)29-11-4-8-19(29)15-5-2-6-16(24)13-15/h2-3,5-7,9-10,12-14,19H,4,8,11H2,1H3,(H,27,31)/t19-/s2
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n/an/a 7.40n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136647
PNG
(US10005783, 64 | US10047097, 64 | US8865698, 64 | ...)
Show SMILES CC(C)(CO)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C21H23F2N5O2/c1-21(2,12-29)20(30)25-16-11-24-28-9-7-18(26-19(16)28)27-8-3-4-17(27)14-10-13(22)5-6-15(14)23/h5-7,9-11,17,29H,3-4,8,12H2,1-2H3,(H,25,30)/t17-/s2
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n/an/a 7.5n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136681
PNG
(US10005783, 98 | US10047097, 98 | US8865698, 98 | ...)
Show SMILES CNC(=O)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C19H18F2N6O2/c1-22-18(28)19(29)24-14-10-23-27-8-6-16(25-17(14)27)26-7-2-3-15(26)12-9-11(20)4-5-13(12)21/h4-6,8-10,15H,2-3,7H2,1H3,(H,22,28)(H,24,29)/t15-/s2
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n/an/a 7.65n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136687
PNG
(US10005783, 104 | US10047097, 104 | US8865698, 104...)
Show SMILES COC(=O)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C19H17F2N5O3/c1-29-19(28)18(27)23-14-10-22-26-8-6-16(24-17(14)26)25-7-2-3-15(25)12-9-11(20)4-5-13(12)21/h4-6,8-10,15H,2-3,7H2,1H3,(H,23,27)/t15-/s2
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n/an/a 7.65n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136664
PNG
(US10005783, 81 | US10047097, 81 | US8865698, 81 | ...)
Show SMILES O[C@H]1CCN(C1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1Cl
Show InChI InChI=1/C21H22ClFN6O2/c22-16-4-3-13(23)10-15(16)18-2-1-7-28(18)19-6-9-29-20(26-19)17(11-24-29)25-21(31)27-8-5-14(30)12-27/h3-4,6,9-11,14,18,30H,1-2,5,7-8,12H2,(H,25,31)/t14-,18+/s2
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n/an/a 8n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136656
PNG
(US10005783, 73 | US10047097, 73 | US8865698, 73 | ...)
Show SMILES Cn1ccc(n1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cccc(F)c1
Show InChI InChI=1/C21H20FN7O/c1-27-10-7-16(26-27)21(30)24-17-13-23-29-11-8-19(25-20(17)29)28-9-3-6-18(28)14-4-2-5-15(22)12-14/h2,4-5,7-8,10-13,18H,3,6,9H2,1H3,(H,24,30)/t18-/s2
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n/an/a 8.5n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136620
PNG
(US10005783, 37 | US10047097, 37 | US8865698, 37 | ...)
Show SMILES O[C@H]1CCN(C1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1C(F)F
Show InChI InChI=1/C22H23F3N6O2/c23-13-3-4-15(20(24)25)16(10-13)18-2-1-7-30(18)19-6-9-31-21(28-19)17(11-26-31)27-22(33)29-8-5-14(32)12-29/h3-4,6,9-11,14,18,20,32H,1-2,5,7-8,12H2,(H,27,33)/t14-,18+/s2
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n/an/a 8.70n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136597
PNG
(US10005783, 14 | US10047097, 14 | US8865698, 14 | ...)
Show SMILES O[C@H]1CCN(C1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C21H22F2N6O2/c22-13-3-4-16(23)15(10-13)18-2-1-7-28(18)19-6-9-29-20(26-19)17(11-24-29)25-21(31)27-8-5-14(30)12-27/h3-4,6,9-11,14,18,30H,1-2,5,7-8,12H2,(H,25,31)/t14-,18+/s2
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n/an/a 9.70n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136602
PNG
(US10005783, 19 | US10047097, 19 | US8865698, 19 | ...)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccn2ncc(NC(=O)Nc3ccc(Cl)cc3)c2n1
Show InChI InChI=1/C23H19ClF2N6O/c24-14-3-6-16(7-4-14)28-23(33)29-19-13-27-32-11-9-21(30-22(19)32)31-10-1-2-20(31)17-12-15(25)5-8-18(17)26/h3-9,11-13,20H,1-2,10H2,(H2,28,29,33)/t20-/s2
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n/an/a 10.1n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136684
PNG
(US10005783, 101 | US10047097, 101 | US8865698, 101...)
Show SMILES OC1CN(C1)C(=O)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C21H20F2N6O3/c22-12-3-4-15(23)14(8-12)17-2-1-6-28(17)18-5-7-29-19(26-18)16(9-24-29)25-20(31)21(32)27-10-13(30)11-27/h3-5,7-9,13,17,30H,1-2,6,10-11H2,(H,25,31)/t17-/s2
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n/an/a 10.1n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136674
PNG
(US10005783, 91 | US10047097, 91 | US8865698, 91 | ...)
Show SMILES COc1ccc(F)cc1[C@H]1CCCN1c1ccn2ncc(NC(=O)N3CCC[C@H](O)C3)c2n1
Show InChI InChI=1/C23H27FN6O3/c1-33-20-7-6-15(24)12-17(20)19-5-3-10-29(19)21-8-11-30-22(27-21)18(13-25-30)26-23(32)28-9-2-4-16(31)14-28/h6-8,11-13,16,19,31H,2-5,9-10,14H2,1H3,(H,26,32)/t16-,19+/s2
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n/an/a 10.2n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136673
PNG
(US10005783, 90 | US10047097, 90 | US8865698, 90 | ...)
Show SMILES COc1ccc(F)cc1[C@H]1CCCN1c1ccn2ncc(NC(=O)N3CC[C@H](O)C3)c2n1
Show InChI InChI=1/C22H25FN6O3/c1-32-19-5-4-14(23)11-16(19)18-3-2-8-28(18)20-7-10-29-21(26-20)17(12-24-29)25-22(31)27-9-6-15(30)13-27/h4-5,7,10-12,15,18,30H,2-3,6,8-9,13H2,1H3,(H,25,31)/t15-,18+/s2
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US Patent
n/an/a 11.3n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136605
PNG
(US10005783, 22 | US10047097, 22 | US8865698, 22 | ...)
Show SMILES CC1(O)CN(C1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1Cl
Show InChI InChI=1/C21H22ClFN6O2/c1-21(31)11-27(12-21)20(30)25-16-10-24-29-8-6-18(26-19(16)29)28-7-2-3-17(28)14-9-13(23)4-5-15(14)22/h4-6,8-10,17,31H,2-3,7,11-12H2,1H3,(H,25,30)/t17-/s2
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n/an/a 11.5n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136626
PNG
(US10005783, 43 | US10047097, 43 | US8865698, 43 | ...)
Show SMILES O[C@@H]1CCCN(C1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1Cl
Show InChI InChI=1/C22H24ClFN6O2/c23-17-6-5-14(24)11-16(17)19-4-2-9-29(19)20-7-10-30-21(27-20)18(12-25-30)26-22(32)28-8-1-3-15(31)13-28/h5-7,10-12,15,19,31H,1-4,8-9,13H2,(H,26,32)/t15-,19-/s2
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n/an/a 11.7n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136588
PNG
(US10005783, 5 | US10047097, 5 | US8865698, 5 | US9...)
Show SMILES CC(C)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C20H21F2N5O/c1-12(2)20(28)24-16-11-23-27-9-7-18(25-19(16)27)26-8-3-4-17(26)14-10-13(21)5-6-15(14)22/h5-7,9-12,17H,3-4,8H2,1-2H3,(H,24,28)/t17-/s2
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n/an/a 12.1n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136633
PNG
(US10005783, 50 | US10047097, 50 | US8865698, 50 | ...)
Show SMILES CC(C)(O)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C20H21F2N5O2/c1-20(2,29)19(28)24-15-11-23-27-9-7-17(25-18(15)27)26-8-3-4-16(26)13-10-12(21)5-6-14(13)22/h5-7,9-11,16,29H,3-4,8H2,1-2H3,(H,24,28)/t16-/s2
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n/an/a 12.4n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM401720
PNG
(US10005783, 102)
Show SMILES O[C@@H]1CCN(C1)C(=O)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C22H22F2N6O3/c23-13-3-4-16(24)15(10-13)18-2-1-7-29(18)19-6-9-30-20(27-19)17(11-25-30)26-21(32)22(33)28-8-5-14(31)12-28/h3-4,6,9-11,14,18,31H,1-2,5,7-8,12H2,(H,26,32)/t14-,18+/m1/s1
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n/an/a 12.8n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136598
PNG
(US10005783, 15 | US10047097, 15 | US8865698, 15)
Show SMILES O[C@@H]1CN(C[C@H]1O)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C21H22F2N6O3/c22-12-3-4-14(23)13(8-12)16-2-1-6-28(16)19-5-7-29-20(26-19)15(9-24-29)25-21(32)27-10-17(30)18(31)11-27/h3-5,7-9,16-18,30-31H,1-2,6,10-11H2,(H,25,32)/t16-,17-,18-/s2
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n/an/a 13.3n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136627
PNG
(US10005783, 44 | US10047097, 44 | US8865698, 44 | ...)
Show SMILES O[C@H]1CCCN(C1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1Cl
Show InChI InChI=1/C22H24ClFN6O2/c23-17-6-5-14(24)11-16(17)19-4-2-9-29(19)20-7-10-30-21(27-20)18(12-25-30)26-22(32)28-8-1-3-15(31)13-28/h5-7,10-12,15,19,31H,1-4,8-9,13H2,(H,26,32)/t15-,19+/s2
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n/an/a 13.4n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136591
PNG
(US10005783, 8 | US10047097, 8 | US8865698, 8 | US9...)
Show SMILES OC1CN(C1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1Cl
Show InChI InChI=1/C20H20ClFN6O2/c21-15-4-3-12(22)8-14(15)17-2-1-6-27(17)18-5-7-28-19(25-18)16(9-23-28)24-20(30)26-10-13(29)11-26/h3-5,7-9,13,17,29H,1-2,6,10-11H2,(H,24,30)/t17-/s2
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n/an/a 13.7n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136669
PNG
(US10005783, 86 | US10047097, 86 | US8865698, 86 | ...)
Show SMILES O[C@@H]1CCCN(C1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1C(F)(F)F
Show InChI InChI=1/C23H24F4N6O2/c24-14-5-6-17(23(25,26)27)16(11-14)19-4-2-9-32(19)20-7-10-33-21(30-20)18(12-28-33)29-22(35)31-8-1-3-15(34)13-31/h5-7,10-12,15,19,34H,1-4,8-9,13H2,(H,29,35)/t15-,19-/s2
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n/an/a 14n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136637
PNG
(US10005783, 54 | US10047097, 54 | US8865698, 54 | ...)
Show SMILES CC(C)(F)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C20H20F3N5O/c1-20(2,23)19(29)25-15-11-24-28-9-7-17(26-18(15)28)27-8-3-4-16(27)13-10-12(21)5-6-14(13)22/h5-7,9-11,16H,3-4,8H2,1-2H3,(H,25,29)/t16-/s2
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n/an/a 14.2n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136639
PNG
(US10005783, 56 | US10047097, 56 | US8865698, 56 | ...)
Show SMILES CC(C)(C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F)n1cncn1
Show InChI InChI=1/C22H22F2N8O/c1-22(2,32-13-25-12-27-32)21(33)28-17-11-26-31-9-7-19(29-20(17)31)30-8-3-4-18(30)15-10-14(23)5-6-16(15)24/h5-7,9-13,18H,3-4,8H2,1-2H3,(H,28,33)/t18-/s2
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n/an/a 14.4n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136670
PNG
(US10005783, 87 | US10047097, 87 | US8865698, 87 | ...)
Show SMILES O[C@H]1CCCN(C1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1C(F)(F)F
Show InChI InChI=1/C23H24F4N6O2/c24-14-5-6-17(23(25,26)27)16(11-14)19-4-2-9-32(19)20-7-10-33-21(30-20)18(12-28-33)29-22(35)31-8-1-3-15(34)13-31/h5-7,10-12,15,19,34H,1-4,8-9,13H2,(H,29,35)/t15-,19+/s2
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n/an/a 14.6n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136631
PNG
(US10005783, 48 | US10047097, 48 | US8865698, 48 | ...)
Show SMILES CC(C)(C)OC(=O)N1CCC(C)(CC1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1Cl
Show InChI InChI=1/C28H34ClFN6O3/c1-27(2,3)39-26(38)34-14-10-28(4,11-15-34)25(37)32-21-17-31-36-13-9-23(33-24(21)36)35-12-5-6-22(35)19-16-18(30)7-8-20(19)29/h7-9,13,16-17,22H,5-6,10-12,14-15H2,1-4H3,(H,32,37)/t22-/s2
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n/an/a 15.3n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136657
PNG
(US10005783, 74 | US10047097, 74 | US8865698, 74 | ...)
Show SMILES Fc1cccc(c1)[C@H]1CCCN1c1ccn2ncc(NC(=O)c3cc[nH]n3)c2n1
Show InChI InChI=1/C20H18FN7O/c21-14-4-1-3-13(11-14)17-5-2-9-27(17)18-7-10-28-19(25-18)16(12-23-28)24-20(29)15-6-8-22-26-15/h1,3-4,6-8,10-12,17H,2,5,9H2,(H,22,26)(H,24,29)/t17-/s2
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n/an/a 15.3n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136585
PNG
(US10005783, 2 | US10047097, 2 | US8865698, 2 | US9...)
Show SMILES CN(C)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C19H20F2N6O/c1-25(2)19(28)23-15-11-22-27-9-7-17(24-18(15)27)26-8-3-4-16(26)13-10-12(20)5-6-14(13)21/h5-7,9-11,16H,3-4,8H2,1-2H3,(H,23,28)/t16-/s2
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n/an/a 15.8n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136683
PNG
(US10005783, 100 | US10047097, 100 | US8865698, 100...)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccn2ncc(NC(=O)C(=O)NC3CC3)c2n1
Show InChI InChI=1/C21H20F2N6O2/c22-12-3-6-15(23)14(10-12)17-2-1-8-28(17)18-7-9-29-19(27-18)16(11-24-29)26-21(31)20(30)25-13-4-5-13/h3,6-7,9-11,13,17H,1-2,4-5,8H2,(H,25,30)(H,26,31)/t17-/s2
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n/an/a 15.8n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136648
PNG
(US10005783, 65 | US10047097, 65 | US8865698, 65 | ...)
Show SMILES OC1(CC1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C20H19F2N5O2/c21-12-3-4-14(22)13(10-12)16-2-1-8-26(16)17-5-9-27-18(25-17)15(11-23-27)24-19(28)20(29)6-7-20/h3-5,9-11,16,29H,1-2,6-8H2,(H,24,28)/t16-/s2
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n/an/a 16.5n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136619
PNG
(US10005783, 36 | US10047097, 36 | US8865698, 36 | ...)
Show SMILES O[C@@H]1CCN(C1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1C(F)F
Show InChI InChI=1/C22H23F3N6O2/c23-13-3-4-15(20(24)25)16(10-13)18-2-1-7-30(18)19-6-9-31-21(28-19)17(11-26-31)27-22(33)29-8-5-14(32)12-29/h3-4,6,9-11,14,18,20,32H,1-2,5,7-8,12H2,(H,27,33)/t14-,18-/s2
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n/an/a 18n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136589
PNG
(BDBM227973 | US10005783, 6 | US8865698, 6 | US9676...)
Show SMILES Cn1nc(ccc1=O)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cccc(F)c1
Show InChI InChI=1/C22H20FN7O2/c1-28-20(31)8-7-16(27-28)22(32)25-17-13-24-30-11-9-19(26-21(17)30)29-10-3-6-18(29)14-4-2-5-15(23)12-14/h2,4-5,7-9,11-13,18H,3,6,10H2,1H3,(H,25,32)/t18-/s2
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n/an/a 19.2n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136600
PNG
(US10005783, 17 | US10047097, 17 | US8865698, 17 | ...)
Show SMILES CC1(O)CN(C1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C21H22F2N6O2/c1-21(31)11-27(12-21)20(30)25-16-10-24-29-8-6-18(26-19(16)29)28-7-2-3-17(28)14-9-13(22)4-5-15(14)23/h4-6,8-10,17,31H,2-3,7,11-12H2,1H3,(H,25,30)/t17-/s2
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n/an/a 19.7n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136618
PNG
(US10005783, 35 | US10047097, 35 | US8865698, 35 | ...)
Show SMILES O[C@H]1CCN(C1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)cc(Cl)c1
Show InChI InChI=1/C21H22ClFN6O2/c22-14-8-13(9-15(23)10-14)18-2-1-5-28(18)19-4-7-29-20(26-19)17(11-24-29)25-21(31)27-6-3-16(30)12-27/h4,7-11,16,18,30H,1-3,5-6,12H2,(H,25,31)/t16-,18+/s2
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n/an/a 20.2n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136677
PNG
(US10005783, 94 | US10047097, 94 | US8865698, 94 | ...)
Show SMILES O[C@@H]1CC[C@@H](C1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C22H23F2N5O2/c23-14-4-6-17(24)16(11-14)19-2-1-8-28(19)20-7-9-29-21(27-20)18(12-25-29)26-22(31)13-3-5-15(30)10-13/h4,6-7,9,11-13,15,19,30H,1-3,5,8,10H2,(H,26,31)/t13-,15+,19+/s2
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n/an/a 20.3n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136584
PNG
(US10005783, 1 | US10047097, 1 | US8865698, 1 | US9...)
Show SMILES OC1CN(C1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C20H20F2N6O2/c21-12-3-4-15(22)14(8-12)17-2-1-6-27(17)18-5-7-28-19(25-18)16(9-23-28)24-20(30)26-10-13(29)11-26/h3-5,7-9,13,17,29H,1-2,6,10-11H2,(H,24,30)/t17-/s2
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n/an/a 20.7n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136586
PNG
(US10005783, 3 | US10047097, 3 | US8865698, 3 | US9...)
Show SMILES CC(C)(C)NC(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C21H24F2N6O/c1-21(2,3)27-20(30)25-16-12-24-29-10-8-18(26-19(16)29)28-9-4-5-17(28)14-11-13(22)6-7-15(14)23/h6-8,10-12,17H,4-5,9H2,1-3H3,(H2,25,27,30)/t17-/s2
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n/an/a 22.2n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136622
PNG
(US10005783, 39 | US10047097, 39 | US8865698, 39 | ...)
Show SMILES O[C@@H]1CCCN(C1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1C(F)F
Show InChI InChI=1/C23H25F3N6O2/c24-14-5-6-16(21(25)26)17(11-14)19-4-2-9-31(19)20-7-10-32-22(29-20)18(12-27-32)28-23(34)30-8-1-3-15(33)13-30/h5-7,10-12,15,19,21,33H,1-4,8-9,13H2,(H,28,34)/t15-,19-/s2
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n/an/a 25.7n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136595
PNG
(US10005783, 12 | US10047097, 12 | US8865698, 12 | ...)
Show SMILES OC1CN(C1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1C(F)F
Show InChI InChI=1/C21H21F3N6O2/c22-12-3-4-14(19(23)24)15(8-12)17-2-1-6-29(17)18-5-7-30-20(27-18)16(9-25-30)26-21(32)28-10-13(31)11-28/h3-5,7-9,13,17,19,31H,1-2,6,10-11H2,(H,26,32)/t17-/s2
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n/an/a 26.5n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136679
PNG
(US10005783, 96 | US10047097, 96 | US8865698, 96 | ...)
Show SMILES OC1CC(C1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C21H21F2N5O2/c22-13-3-4-16(23)15(10-13)18-2-1-6-27(18)19-5-7-28-20(26-19)17(11-24-28)25-21(30)12-8-14(29)9-12/h3-5,7,10-12,14,18,29H,1-2,6,8-9H2,(H,25,30)/t12?,14?,18-/s2
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n/an/a 27.4n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136599
PNG
(US10005783, 16 | US10047097, 16 | US8865698, 16 | ...)
Show SMILES COC1CN(C1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C21H22F2N6O2/c1-31-14-11-27(12-14)21(30)25-17-10-24-29-8-6-19(26-20(17)29)28-7-2-3-18(28)15-9-13(22)4-5-16(15)23/h4-6,8-10,14,18H,2-3,7,11-12H2,1H3,(H,25,30)/t18-/s2
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n/an/a 27.5n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136604
PNG
(US10005783, 21 | US10047097, 21 | US8865698, 21 | ...)
Show SMILES COC1CN(C1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1Cl
Show InChI InChI=1/C21H22ClFN6O2/c1-31-14-11-27(12-14)21(30)25-17-10-24-29-8-6-19(26-20(17)29)28-7-2-3-18(28)15-9-13(23)4-5-16(15)22/h4-6,8-10,14,18H,2-3,7,11-12H2,1H3,(H,25,30)/t18-/s2
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n/an/a 27.9n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136625
PNG
(US10005783, 42 | US10047097, 42 | US8865698, 42 | ...)
Show SMILES OC1CCN(CC1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1Cl
Show InChI InChI=1/C22H24ClFN6O2/c23-17-4-3-14(24)12-16(17)19-2-1-8-29(19)20-7-11-30-21(27-20)18(13-25-30)26-22(32)28-9-5-15(31)6-10-28/h3-4,7,11-13,15,19,31H,1-2,5-6,8-10H2,(H,26,32)/t19-/s2
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n/an/a 28.3n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136676
PNG
(US10005783, 93 | US10047097, 93 | US8865698, 93 | ...)
Show SMILES O[C@@H]1CCN(C1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C21H22F2N6O2/c22-13-3-4-16(23)15(10-13)18-2-1-7-28(18)19-6-9-29-20(26-19)17(11-24-29)25-21(31)27-8-5-14(30)12-27/h3-4,6,9-11,14,18,30H,1-2,5,7-8,12H2,(H,25,31)/t14-,18-/s2
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n/an/a 28.5n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136632
PNG
(US10005783, 49 | US8865698, 49 | US9676783, 49)
Show SMILES CC1(CCNCC1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1Cl
Show InChI InChI=1/C23H26ClFN6O/c1-23(7-9-26-10-8-23)22(32)28-18-14-27-31-12-6-20(29-21(18)31)30-11-2-3-19(30)16-13-15(25)4-5-17(16)24/h4-6,12-14,19,26H,2-3,7-11H2,1H3,(H,28,32)/t19-/s2
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n/an/a 29.2n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136623
PNG
(US10005783, 40 | US10047097, 40 | US8865698, 40 | ...)
Show SMILES O[C@H]1CCCN(C1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1C(F)F
Show InChI InChI=1/C23H25F3N6O2/c24-14-5-6-16(21(25)26)17(11-14)19-4-2-9-31(19)20-7-10-32-22(29-20)18(12-27-32)28-23(34)30-8-1-3-15(33)13-30/h5-7,10-12,15,19,21,33H,1-4,8-9,13H2,(H,28,34)/t15-,19+/s2
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n/an/a 30.8n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136636
PNG
(US10005783, 53 | US10047097, 53 | US8865698, 53 | ...)
Show SMILES C[C@@]1(CCCN1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C22H24F2N6O/c1-22(8-3-9-25-22)21(31)27-17-13-26-30-11-7-19(28-20(17)30)29-10-2-4-18(29)15-12-14(23)5-6-16(15)24/h5-7,11-13,18,25H,2-4,8-10H2,1H3,(H,27,31)/t18-,22-/s2
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n/an/a 31n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136596
PNG
(US10005783, 13 | US10047097, 13 | US8865698, 13 | ...)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccn2ncc(NC(=O)N3CCOCC3)c2n1
Show InChI InChI=1/C21H22F2N6O2/c22-14-3-4-16(23)15(12-14)18-2-1-6-28(18)19-5-7-29-20(26-19)17(13-24-29)25-21(30)27-8-10-31-11-9-27/h3-5,7,12-13,18H,1-2,6,8-11H2,(H,25,30)/t18-/s2
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n/an/a 32.2n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136666
PNG
(US10005783, 83 | US10047097, 83 | US8865698, 83 | ...)
Show SMILES Cn1ccnc1C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cccc(F)c1
Show InChI InChI=1/C21H20FN7O/c1-27-11-8-23-20(27)21(30)25-16-13-24-29-10-7-18(26-19(16)29)28-9-3-6-17(28)14-4-2-5-15(22)12-14/h2,4-5,7-8,10-13,17H,3,6,9H2,1H3,(H,25,30)/t17-/s2
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n/an/a 35.4n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136629
PNG
(US10005783, 46 | US10047097, 46 | US8865698, 46 | ...)
Show SMILES CC(C)(C)OC(=O)N1CC(C1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1Cl
Show InChI InChI=1/C25H28ClFN6O3/c1-25(2,3)36-24(35)31-13-15(14-31)23(34)29-19-12-28-33-10-8-21(30-22(19)33)32-9-4-5-20(32)17-11-16(27)6-7-18(17)26/h6-8,10-12,15,20H,4-5,9,13-14H2,1-3H3,(H,29,34)/t20-/s2
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n/an/a 37.3n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136606
PNG
(US10005783, 23 | US10047097, 23 | US8865698, 23 | ...)
Show SMILES Fc1ccc(Cl)c(c1)[C@H]1CCCN1c1ccn2ncc(NC(=O)N3CCOCC3)c2n1
Show InChI InChI=1/C21H22ClFN6O2/c22-16-4-3-14(23)12-15(16)18-2-1-6-28(18)19-5-7-29-20(26-19)17(13-24-29)25-21(30)27-8-10-31-11-9-27/h3-5,7,12-13,18H,1-2,6,8-11H2,(H,25,30)/t18-/s2
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n/an/a 41.7n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136678
PNG
(US10005783, 95 | US10047097, 95 | US8865698, 95 | ...)
Show SMILES O[C@H]1CC[C@@H](C1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C22H23F2N5O2/c23-14-4-6-17(24)16(11-14)19-2-1-8-28(19)20-7-9-29-21(27-20)18(12-25-29)26-22(31)13-3-5-15(30)10-13/h4,6-7,9,11-13,15,19,30H,1-3,5,8,10H2,(H,26,31)/t13-,15-,19+/s2
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n/an/a 42.5n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136609
PNG
(US10005783, 26 | US10047097, 26 | US8865698, 26 | ...)
Show SMILES CC(C)N1CCN(CC1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C24H29F2N7O/c1-16(2)30-10-12-31(13-11-30)24(34)28-20-15-27-33-9-7-22(29-23(20)33)32-8-3-4-21(32)18-14-17(25)5-6-19(18)26/h5-7,9,14-16,21H,3-4,8,10-13H2,1-2H3,(H,28,34)/t21-/s2
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n/an/a 45n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136655
PNG
(US10005783, 72 | US10047097, 72 | US8865698, 72 | ...)
Show SMILES CCS(=O)(=O)Nc1ccc(cc1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cccc(F)c1
Show InChI InChI=1/C25H25FN6O3S/c1-2-36(34,35)30-20-10-8-17(9-11-20)25(33)28-21-16-27-32-14-12-23(29-24(21)32)31-13-4-7-22(31)18-5-3-6-19(26)15-18/h3,5-6,8-12,14-16,22,30H,2,4,7,13H2,1H3,(H,28,33)/t22-/s2
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n/an/a 45.5n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136661
PNG
(US10005783, 78 | US10047097, 78 | US8865698, 78 | ...)
Show SMILES Cc1ccc(cn1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cccc(F)c1
Show InChI InChI=1/C23H21FN6O/c1-15-7-8-17(13-25-15)23(31)27-19-14-26-30-11-9-21(28-22(19)30)29-10-3-6-20(29)16-4-2-5-18(24)12-16/h2,4-5,7-9,11-14,20H,3,6,10H2,1H3,(H,27,31)/t20-/s2
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n/an/a 47n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136680
PNG
(US10005783, 97 | US10047097, 97 | US8865698, 97 | ...)
Show SMILES CN(C)C(=O)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C20H20F2N6O2/c1-26(2)20(30)19(29)24-15-11-23-28-9-7-17(25-18(15)28)27-8-3-4-16(27)13-10-12(21)5-6-14(13)22/h5-7,9-11,16H,3-4,8H2,1-2H3,(H,24,29)/t16-/s2
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n/an/a 47.5n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136649
PNG
(US10005783, 66 | US10047097, 66 | US8865698, 66 | ...)
Show SMILES CNC(C)(C)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C21H24F2N6O/c1-21(2,24-3)20(30)26-16-12-25-29-10-8-18(27-19(16)29)28-9-4-5-17(28)14-11-13(22)6-7-15(14)23/h6-8,10-12,17,24H,4-5,9H2,1-3H3,(H,26,30)/t17-/s2
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n/an/a 52.5n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136659
PNG
(US10005783, 76 | US10047097, 76 | US8865698, 76 | ...)
Show SMILES Fc1cccc(c1)[C@H]1CCCN1c1ccn2ncc(NC(=O)c3cccnc3)c2n1
Show InChI InChI=1/C22H19FN6O/c23-17-6-1-4-15(12-17)19-7-3-10-28(19)20-8-11-29-21(27-20)18(14-25-29)26-22(30)16-5-2-9-24-13-16/h1-2,4-6,8-9,11-14,19H,3,7,10H2,(H,26,30)/t19-/s2
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n/an/a 53.3n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136607
PNG
(US10005783, 24 | US10047097, 24 | US8865698, 24 | ...)
Show SMILES C[C@H]1CN(CCN1C(=O)OC(C)(C)C)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1Cl
Show InChI InChI=1/C27H33ClFN7O3/c1-17-16-33(12-13-34(17)26(38)39-27(2,3)4)25(37)31-21-15-30-36-11-9-23(32-24(21)36)35-10-5-6-22(35)19-14-18(29)7-8-20(19)28/h7-9,11,14-15,17,22H,5-6,10,12-13,16H2,1-4H3,(H,31,37)/t17-,22+/s2
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n/an/a 55n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136653
PNG
(US10005783, 70 | US10047097, 70 | US8865698, 70 | ...)
Show SMILES Cn1ccc(cc1=O)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cccc(F)c1
Show InChI InChI=1/C23H21FN6O2/c1-28-10-7-16(13-21(28)31)23(32)26-18-14-25-30-11-8-20(27-22(18)30)29-9-3-6-19(29)15-4-2-5-17(24)12-15/h2,4-5,7-8,10-14,19H,3,6,9H2,1H3,(H,26,32)/t19-/s2
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n/an/a 55.6n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136611
PNG
(US10005783, 28 | US10047097, 28 | US8865698, 28 | ...)
Show SMILES CN1CCN(CC1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C22H25F2N7O/c1-28-9-11-29(12-10-28)22(32)26-18-14-25-31-8-6-20(27-21(18)31)30-7-2-3-19(30)16-13-15(23)4-5-17(16)24/h4-6,8,13-14,19H,2-3,7,9-12H2,1H3,(H,26,32)/t19-/s2
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n/an/a 57.4n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136660
PNG
(US10005783, 77 | US10047097, 77 | US8865698, 77 | ...)
Show SMILES Fc1cccc(c1)[C@H]1CCCN1c1ccn2ncc(NC(=O)c3ccncc3)c2n1
Show InChI InChI=1/C22H19FN6O/c23-17-4-1-3-16(13-17)19-5-2-11-28(19)20-8-12-29-21(27-20)18(14-25-29)26-22(30)15-6-9-24-10-7-15/h1,3-4,6-10,12-14,19H,2,5,11H2,(H,26,30)/t19-/s2
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n/an/a 71.8n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136590
PNG
(US10005783, 7 | US10047097, 7 | US8865698, 7 | US9...)
Show SMILES OC1CN(C1)C(=O)Nc1cnn2ccc(nc12)N1CC(F)(F)C[C@@H]1c1cccc(F)c1
Show InChI InChI=1/C20H19F3N6O2/c21-13-3-1-2-12(6-13)16-7-20(22,23)11-28(16)17-4-5-29-18(26-17)15(8-24-29)25-19(31)27-9-14(30)10-27/h1-6,8,14,16,30H,7,9-11H2,(H,25,31)/t16-/s2
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n/an/a 77.5n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136608
PNG
(US10005783, 25 | US8865698, 25 | US9676783, 25)
Show SMILES C[C@H]1CN(CCN1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1Cl
Show InChI InChI=1/C22H25ClFN7O/c1-14-13-29(10-7-25-14)22(32)27-18-12-26-31-9-6-20(28-21(18)31)30-8-2-3-19(30)16-11-15(24)4-5-17(16)23/h4-6,9,11-12,14,19,25H,2-3,7-8,10,13H2,1H3,(H,27,32)/t14-,19+/s2
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n/an/a 82.3n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136686
PNG
(US10005783, 103 | US10047097, 103 | US8865698, 103...)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccn2ncc(NC(=O)C(=O)N3CCOCC3)c2n1
Show InChI InChI=1/C22H22F2N6O3/c23-14-3-4-16(24)15(12-14)18-2-1-6-29(18)19-5-7-30-20(27-19)17(13-25-30)26-21(31)22(32)28-8-10-33-11-9-28/h3-5,7,12-13,18H,1-2,6,8-11H2,(H,26,31)/t18-/s2
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n/an/a 82.4n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136621
PNG
(US10005783, 38 | US10047097, 38 | US8865698, 38 | ...)
Show SMILES OC1CCN(CC1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1C(F)F
Show InChI InChI=1/C23H25F3N6O2/c24-14-3-4-16(21(25)26)17(12-14)19-2-1-8-31(19)20-7-11-32-22(29-20)18(13-27-32)28-23(34)30-9-5-15(33)6-10-30/h3-4,7,11-13,15,19,21,33H,1-2,5-6,8-10H2,(H,28,34)/t19-/s2
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n/an/a 85.5n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136614
PNG
(US10005783, 31 | US8865698, 31 | US9676783, 31)
Show SMILES C[C@H]1CN(CCN1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C22H25F2N7O/c1-14-13-29(10-7-25-14)22(32)27-18-12-26-31-9-6-20(28-21(18)31)30-8-2-3-19(30)16-11-15(23)4-5-17(16)24/h4-6,9,11-12,14,19,25H,2-3,7-8,10,13H2,1H3,(H,27,32)/t14-,19+/s2
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n/an/a 88.3n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136612
PNG
(US10005783, 29 | US10047097, 29 | US8865698, 29 | ...)
Show SMILES CC1CN(CC(C)N1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C23H27F2N7O/c1-14-12-30(13-15(2)27-14)23(33)28-19-11-26-32-9-7-21(29-22(19)32)31-8-3-4-20(31)17-10-16(24)5-6-18(17)25/h5-7,9-11,14-15,20,27H,3-4,8,12-13H2,1-2H3,(H,28,33)/t14?,15?,20-/s2
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n/an/a 98n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136617
PNG
(US10005783, 34 | US10047097, 34 | US8865698, 34 | ...)
Show SMILES OC(=O)C1(CC1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C21H19F2N5O3/c22-12-3-4-14(23)13(10-12)16-2-1-8-27(16)17-5-9-28-18(26-17)15(11-24-28)25-19(29)21(6-7-21)20(30)31/h3-5,9-11,16H,1-2,6-8H2,(H,25,29)(H,30,31)/t16-/s2
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n/an/a 98.2n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136610
PNG
(US10005783, 27 | US10047097, 27 | US8865698, 27 | ...)
Show SMILES CCN1CCN(CC1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C23H27F2N7O/c1-2-29-10-12-30(13-11-29)23(33)27-19-15-26-32-9-7-21(28-22(19)32)31-8-3-4-20(31)17-14-16(24)5-6-18(17)25/h5-7,9,14-15,20H,2-4,8,10-13H2,1H3,(H,27,33)/t20-/s2
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n/an/a 107n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136675
PNG
(US10005783, 92 | US10047097, 92 | US8865698, 92 | ...)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccn2ncc(NC(=O)N3C[C@@H]4C[C@H]3CO4)c2n1
Show InChI InChI=1/C22H22F2N6O2/c23-13-3-4-17(24)16(8-13)19-2-1-6-28(19)20-5-7-30-21(27-20)18(10-25-30)26-22(31)29-11-15-9-14(29)12-32-15/h3-5,7-8,10,14-15,19H,1-2,6,9,11-12H2,(H,26,31)/t14-,15-,19+/s2
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n/an/a 107n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136615
PNG
(US10005783, 32 | US10047097, 32 | US8865698, 32 | ...)
Show SMILES OC1CN(C1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cccc(F)c1
Show InChI InChI=1/C20H21FN6O2/c21-14-4-1-3-13(9-14)17-5-2-7-26(17)18-6-8-27-19(24-18)16(10-22-27)23-20(29)25-11-15(28)12-25/h1,3-4,6,8-10,15,17,28H,2,5,7,11-12H2,(H,23,29)/t17-/s2
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n/an/a 116n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136613
PNG
(US10005783, 30 | US10047097, 30 | US8865698, 30 | ...)
Show SMILES C[C@H]1CN(CCN1C(=O)OC(C)(C)C)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C27H33F2N7O3/c1-17-16-33(12-13-34(17)26(38)39-27(2,3)4)25(37)31-21-15-30-36-11-9-23(32-24(21)36)35-10-5-6-22(35)19-14-18(28)7-8-20(19)29/h7-9,11,14-15,17,22H,5-6,10,12-13,16H2,1-4H3,(H,31,37)/t17-,22+/s2
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n/an/a 154n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136671
PNG
(US10005783, 88 | US10047097, 88 | US8865698, 88 | ...)
Show SMILES O[C@H]1CCN(C1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cncc(F)c1
Show InChI InChI=1/C20H22FN7O2/c21-14-8-13(9-22-10-14)17-2-1-5-27(17)18-4-7-28-19(25-18)16(11-23-28)24-20(30)26-6-3-15(29)12-26/h4,7-11,15,17,29H,1-3,5-6,12H2,(H,24,30)/t15-,17+/s2
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n/an/a 156n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136594
PNG
(US10005783, 11 | US10047097, 11 | US8865698, 11 | ...)
Show SMILES OC1CN(C1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)cc(Cl)c1
Show InChI InChI=1/C20H20ClFN6O2/c21-13-6-12(7-14(22)8-13)17-2-1-4-27(17)18-3-5-28-19(25-18)16(9-23-28)24-20(30)26-10-15(29)11-26/h3,5-9,15,17,29H,1-2,4,10-11H2,(H,24,30)/t17-/s2
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US Patent
n/an/a 171n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136593
PNG
(US10005783, 10 | US10047097, 10 | US8865698, 10 | ...)
Show SMILES CC1(CCCN1c1ccn2ncc(NC(=O)N3CC(O)C3)c2n1)c1cccc(F)c1
Show InChI InChI=1/C21H23FN6O2/c1-21(14-4-2-5-15(22)10-14)7-3-8-27(21)18-6-9-28-19(25-18)17(11-23-28)24-20(30)26-12-16(29)13-26/h2,4-6,9-11,16,29H,3,7-8,12-13H2,1H3,(H,24,30)
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n/an/a 188n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136630
PNG
(US10005783, 47 | US8865698, 47 | US9676783, 47)
Show SMILES Fc1ccc(Cl)c(c1)[C@H]1CCCN1c1ccn2ncc(NC(=O)C3CNC3)c2n1
Show InChI InChI=1/C20H20ClFN6O/c21-15-4-3-13(22)8-14(15)17-2-1-6-27(17)18-5-7-28-19(26-18)16(11-24-28)25-20(29)12-9-23-10-12/h3-5,7-8,11-12,17,23H,1-2,6,9-10H2,(H,25,29)/t17-/s2
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n/an/a 190n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136663
PNG
(US10005783, 80 | US10047097, 80 | US8865698, 80 | ...)
Show SMILES Cc1cnccc1C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cccc(F)c1
Show InChI InChI=1/C23H21FN6O/c1-15-13-25-9-7-18(15)23(31)27-19-14-26-30-11-8-21(28-22(19)30)29-10-3-6-20(29)16-4-2-5-17(24)12-16/h2,4-5,7-9,11-14,20H,3,6,10H2,1H3,(H,27,31)/t20-/s2
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n/an/a 320n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136592
PNG
(US10005783, 9 | US10047097, 9 | US8865698, 9 | US9...)
Show SMILES Fc1cccc(c1)[C@H]1CCCN1c1ccn2ncc(NC(=O)N3CCOCC3)c2n1
Show InChI InChI=1/C21H23FN6O2/c22-16-4-1-3-15(13-16)18-5-2-7-27(18)19-6-8-28-20(25-19)17(14-23-28)24-21(29)26-9-11-30-12-10-26/h1,3-4,6,8,13-14,18H,2,5,7,9-12H2,(H,24,29)/t18-/s2
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n/an/a 821n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM136672
PNG
(US10005783, 89 | US10047097, 89 | US8865698, 89 | ...)
Show SMILES O[C@@H]1CCN(C1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cncc(F)c1
Show InChI InChI=1/C20H22FN7O2/c21-14-8-13(9-22-10-14)17-2-1-5-27(17)18-4-7-28-19(25-18)16(11-23-28)24-20(30)26-6-3-15(29)12-26/h4,7-11,15,17,29H,1-3,5-6,12H2,(H,24,30)/t15-,17-/s2
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US Patent
n/an/a 896n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10005783 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%