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Patent code US10005788

Compile Data Set for Download or QSAR
Found 52 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM401628
PNG
(US10005788, 7 (1st peak))
Show SMILES CCCNc1ncc2c(nc([C@@H]3CC[C@H](O)CC3)n2n1)-c1ccc(N2CCOCC2)c(F)c1
Show InChI InChI=1S/C24H31FN6O2/c1-2-9-26-24-27-15-21-22(28-23(31(21)29-24)16-3-6-18(32)7-4-16)17-5-8-20(19(25)14-17)30-10-12-33-13-11-30/h5,8,14-16,18,32H,2-4,6-7,9-13H2,1H3,(H,26,29)/t16-,18+
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Incyte Corporation

US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10005788 (2018)


BindingDB Entry DOI: 10.7270/Q21R6ST2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM401630
PNG
(US10005788, 8 (1st peak))
Show SMILES CCCCNc1ncc2c(nc([C@H]3CC[C@H](O)CC3)n2n1)-c1cccc(CO)c1
Show InChI InChI=1S/C22H29N5O2/c1-2-3-11-23-22-24-13-19-20(17-6-4-5-15(12-17)14-28)25-21(27(19)26-22)16-7-9-18(29)10-8-16/h4-6,12-13,16,18,28-29H,2-3,7-11,14H2,1H3,(H,23,26)/t16-,18-
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Incyte Corporation

US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10005788 (2018)


BindingDB Entry DOI: 10.7270/Q21R6ST2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM246861
PNG
(3-[1-(6- chloropyridin-2- yl)pyrrolidin-3-yl]-3- [...)
Show SMILES Clc1cccc(n1)N1CCC(C1)C(CC#N)n1cc(cn1)-c1ncnc2[nH]ccc12
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Incyte Corporation

US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10005788 (2018)


BindingDB Entry DOI: 10.7270/Q21R6ST2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM401640
PNG
(US10005788, 14)
Show SMILES N[C@H]1CC[C@H](Cc2nc(-c3ccc(F)cc3)c3cnc(NCCCc4ccccc4)nn23)CC1
Show InChI InChI=1S/C27H31FN6/c28-22-12-10-21(11-13-22)26-24-18-31-27(30-16-4-7-19-5-2-1-3-6-19)33-34(24)25(32-26)17-20-8-14-23(29)15-9-20/h1-3,5-6,10-13,18,20,23H,4,7-9,14-17,29H2,(H,30,33)/t20-,23-
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Incyte Corporation

US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10005788 (2018)


BindingDB Entry DOI: 10.7270/Q21R6ST2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM401639
PNG
(US10005788, 13)
Show SMILES CCCCNc1ncc2c(nc(C[C@H]3CC[C@H](N)CC3)n2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C22H29FN6/c1-2-3-12-25-22-26-14-19-21(16-6-8-17(23)9-7-16)27-20(29(19)28-22)13-15-4-10-18(24)11-5-15/h6-9,14-15,18H,2-5,10-13,24H2,1H3,(H,25,28)/t15-,18-
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Incyte Corporation

US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10005788 (2018)


BindingDB Entry DOI: 10.7270/Q21R6ST2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM401624
PNG
(US10005788, 5 (1st peak, trans-))
Show SMILES CCCCNc1ncc2c(nc([C@@H]3CC[C@H](O)CC3)n2n1)-c1ccc(cc1)N1CCNCC1
Show InChI InChI=1S/C25H35N7O/c1-2-3-12-27-25-28-17-22-23(18-4-8-20(9-5-18)31-15-13-26-14-16-31)29-24(32(22)30-25)19-6-10-21(33)11-7-19/h4-5,8-9,17,19,21,26,33H,2-3,6-7,10-16H2,1H3,(H,27,30)/t19-,21+
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Incyte Corporation

US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10005788 (2018)


BindingDB Entry DOI: 10.7270/Q21R6ST2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM401620
PNG
(US10005788, 3 (1st peak, trans-))
Show SMILES CCCCNc1ncc2c(nc([C@@H]3CC[C@H](O)CC3)n2n1)-c1ccc(CO)cc1
Show InChI InChI=1S/C22H29N5O2/c1-2-3-12-23-22-24-13-19-20(16-6-4-15(14-28)5-7-16)25-21(27(19)26-22)17-8-10-18(29)11-9-17/h4-7,13,17-18,28-29H,2-3,8-12,14H2,1H3,(H,23,26)/t17-,18+
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US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10005788 (2018)


BindingDB Entry DOI: 10.7270/Q21R6ST2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM246883
PNG
(US10005788, 1 (2nd peak, cis-) | US10053465, 22 | ...)
Show SMILES O[C@H]1CCN(Cc2cc(O[C@H]3CC[C@H](CC3)N3CC(CC#N)(C3)n3cc(cn3)-c3ncnc4[nH]ccc34)nc(c2)C(F)(F)F)C1
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US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10005788 (2018)


BindingDB Entry DOI: 10.7270/Q21R6ST2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM401633
PNG
(US10005788, 10 (1st peak))
Show SMILES CCCCNc1ncc2c(nc([C@H]3CC[C@H](O)CC3)n2n1)-c1ccc(NC(C)=O)cc1
Show InChI InChI=1S/C23H30N6O2/c1-3-4-13-24-23-25-14-20-21(16-5-9-18(10-6-16)26-15(2)30)27-22(29(20)28-23)17-7-11-19(31)12-8-17/h5-6,9-10,14,17,19,31H,3-4,7-8,11-13H2,1-2H3,(H,24,28)(H,26,30)/t17-,19-
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Incyte Corporation

US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10005788 (2018)


BindingDB Entry DOI: 10.7270/Q21R6ST2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM246861
PNG
(3-[1-(6- chloropyridin-2- yl)pyrrolidin-3-yl]-3- [...)
Show SMILES Clc1cccc(n1)N1CCC(C1)C(CC#N)n1cc(cn1)-c1ncnc2[nH]ccc12
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Incyte Corporation

US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10005788 (2018)


BindingDB Entry DOI: 10.7270/Q21R6ST2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM401638
PNG
(US10005788, 12 (2nd peak))
Show SMILES CCCCNc1ncc2c(nc([C@@H]3CC[C@H](O)CC3)n2n1)-c1ccc(CNC2CCCCC2)cc1
Show InChI InChI=1S/C28H40N6O/c1-2-3-17-29-28-31-19-25-26(32-27(34(25)33-28)22-13-15-24(35)16-14-22)21-11-9-20(10-12-21)18-30-23-7-5-4-6-8-23/h9-12,19,22-24,30,35H,2-8,13-18H2,1H3,(H,29,33)/t22-,24+
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US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10005788 (2018)


BindingDB Entry DOI: 10.7270/Q21R6ST2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM401622
PNG
(US10005788, 4 (1st peak))
Show SMILES CCCCNc1ncc2c(nc([C@H]3CC[C@H](O)CC3)n2n1)-c1ccc2[nH]ccc2c1
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US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10005788 (2018)


BindingDB Entry DOI: 10.7270/Q21R6ST2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM401626
PNG
(US10005788, 6 (1st peak, trans-))
Show SMILES CCCCNc1ncc2c(nc([C@H]3CC[C@H](O)CC3)n2n1)-c1ccnc(c1)N1CCNCC1
Show InChI InChI=1S/C24H34N8O/c1-2-3-9-27-24-28-16-20-22(18-8-10-26-21(15-18)31-13-11-25-12-14-31)29-23(32(20)30-24)17-4-6-19(33)7-5-17/h8,10,15-17,19,25,33H,2-7,9,11-14H2,1H3,(H,27,30)/t17-,19-
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US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10005788 (2018)


BindingDB Entry DOI: 10.7270/Q21R6ST2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM246883
PNG
(US10005788, 1 (2nd peak, cis-) | US10053465, 22 | ...)
Show SMILES O[C@H]1CCN(Cc2cc(O[C@H]3CC[C@H](CC3)N3CC(CC#N)(C3)n3cc(cn3)-c3ncnc4[nH]ccc34)nc(c2)C(F)(F)F)C1
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US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10005788 (2018)


BindingDB Entry DOI: 10.7270/Q21R6ST2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM401641
PNG
(US10005788, 15)
Show SMILES CCCCNc1ncc2c(nc(C3CCC(N)CC3)n2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C21H27FN6/c1-2-3-12-24-21-25-13-18-19(14-4-8-16(22)9-5-14)26-20(28(18)27-21)15-6-10-17(23)11-7-15/h4-5,8-9,13,15,17H,2-3,6-7,10-12,23H2,1H3,(H,24,27)
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US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10005788 (2018)


BindingDB Entry DOI: 10.7270/Q21R6ST2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM401638
PNG
(US10005788, 12 (2nd peak))
Show SMILES CCCCNc1ncc2c(nc([C@@H]3CC[C@H](O)CC3)n2n1)-c1ccc(CNC2CCCCC2)cc1
Show InChI InChI=1S/C28H40N6O/c1-2-3-17-29-28-31-19-25-26(32-27(34(25)33-28)22-13-15-24(35)16-14-22)21-11-9-20(10-12-21)18-30-23-7-5-4-6-8-23/h9-12,19,22-24,30,35H,2-8,13-18H2,1H3,(H,29,33)/t22-,24+
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Incyte Corporation

US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10005788 (2018)


BindingDB Entry DOI: 10.7270/Q21R6ST2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM401636
PNG
(US10005788, 11 (2nd peak))
Show SMILES CCCCNc1ncc2c(nc([C@H]3CC[C@H](O)CC3)n2n1)-c1ccc(CNC)cc1
Show InChI InChI=1S/C23H32N6O/c1-3-4-13-25-23-26-15-20-21(17-7-5-16(6-8-17)14-24-2)27-22(29(20)28-23)18-9-11-19(30)12-10-18/h5-8,15,18-19,24,30H,3-4,9-14H2,1-2H3,(H,25,28)/t18-,19-
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Incyte Corporation

US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10005788 (2018)


BindingDB Entry DOI: 10.7270/Q21R6ST2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM246883
PNG
(US10005788, 1 (2nd peak, cis-) | US10053465, 22 | ...)
Show SMILES O[C@H]1CCN(Cc2cc(O[C@H]3CC[C@H](CC3)N3CC(CC#N)(C3)n3cc(cn3)-c3ncnc4[nH]ccc34)nc(c2)C(F)(F)F)C1
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Incyte Corporation

US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10005788 (2018)


BindingDB Entry DOI: 10.7270/Q21R6ST2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM401631
PNG
(US10005788, 9 (1st peak))
Show SMILES CCCCNc1ncc2c(nc([C@@H]3CC[C@H](O)CC3)n2n1)-c1cccc(NC(C)=O)c1
Show InChI InChI=1S/C23H30N6O2/c1-3-4-12-24-23-25-14-20-21(17-6-5-7-18(13-17)26-15(2)30)27-22(29(20)28-23)16-8-10-19(31)11-9-16/h5-7,13-14,16,19,31H,3-4,8-12H2,1-2H3,(H,24,28)(H,26,30)/t16-,19+
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Incyte Corporation

US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10005788 (2018)


BindingDB Entry DOI: 10.7270/Q21R6ST2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM401628
PNG
(US10005788, 7 (1st peak))
Show SMILES CCCNc1ncc2c(nc([C@@H]3CC[C@H](O)CC3)n2n1)-c1ccc(N2CCOCC2)c(F)c1
Show InChI InChI=1S/C24H31FN6O2/c1-2-9-26-24-27-15-21-22(28-23(31(21)29-24)16-3-6-18(32)7-4-16)17-5-8-20(19(25)14-17)30-10-12-33-13-11-30/h5,8,14-16,18,32H,2-4,6-7,9-13H2,1H3,(H,26,29)/t16-,18+
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Incyte Corporation

US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10005788 (2018)


BindingDB Entry DOI: 10.7270/Q21R6ST2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM246861
PNG
(3-[1-(6- chloropyridin-2- yl)pyrrolidin-3-yl]-3- [...)
Show SMILES Clc1cccc(n1)N1CCC(C1)C(CC#N)n1cc(cn1)-c1ncnc2[nH]ccc12
PDB
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Incyte Corporation

US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10005788 (2018)


BindingDB Entry DOI: 10.7270/Q21R6ST2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM401641
PNG
(US10005788, 15)
Show SMILES CCCCNc1ncc2c(nc(C3CCC(N)CC3)n2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C21H27FN6/c1-2-3-12-24-21-25-13-18-19(14-4-8-16(22)9-5-14)26-20(28(18)27-21)15-6-10-17(23)11-7-15/h4-5,8-9,13,15,17H,2-3,6-7,10-12,23H2,1H3,(H,24,27)
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Incyte Corporation

US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10005788 (2018)


BindingDB Entry DOI: 10.7270/Q21R6ST2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM401625
PNG
(US10005788, 5 (2nd peak, cis-))
Show SMILES CCCCNc1ncc2c(nc([C@H]3CC[C@H](O)CC3)n2n1)-c1ccc(cc1)N1CCNCC1
Show InChI InChI=1S/C25H35N7O/c1-2-3-12-27-25-28-17-22-23(18-4-8-20(9-5-18)31-15-13-26-14-16-31)29-24(32(22)30-25)19-6-10-21(33)11-7-19/h4-5,8-9,17,19,21,26,33H,2-3,6-7,10-16H2,1H3,(H,27,30)/t19-,21-
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Incyte Corporation

US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10005788 (2018)


BindingDB Entry DOI: 10.7270/Q21R6ST2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM401637
PNG
(US10005788, 12 (1st peak))
Show SMILES CCCCNc1ncc2c(nc([C@H]3CC[C@H](O)CC3)n2n1)-c1ccc(CNC2CCCCC2)cc1
Show InChI InChI=1S/C28H40N6O/c1-2-3-17-29-28-31-19-25-26(32-27(34(25)33-28)22-13-15-24(35)16-14-22)21-11-9-20(10-12-21)18-30-23-7-5-4-6-8-23/h9-12,19,22-24,30,35H,2-8,13-18H2,1H3,(H,29,33)/t22-,24-
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Incyte Corporation

US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10005788 (2018)


BindingDB Entry DOI: 10.7270/Q21R6ST2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM401637
PNG
(US10005788, 12 (1st peak))
Show SMILES CCCCNc1ncc2c(nc([C@H]3CC[C@H](O)CC3)n2n1)-c1ccc(CNC2CCCCC2)cc1
Show InChI InChI=1S/C28H40N6O/c1-2-3-17-29-28-31-19-25-26(32-27(34(25)33-28)22-13-15-24(35)16-14-22)21-11-9-20(10-12-21)18-30-23-7-5-4-6-8-23/h9-12,19,22-24,30,35H,2-8,13-18H2,1H3,(H,29,33)/t22-,24-
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US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10005788 (2018)


BindingDB Entry DOI: 10.7270/Q21R6ST2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM401636
PNG
(US10005788, 11 (2nd peak))
Show SMILES CCCCNc1ncc2c(nc([C@H]3CC[C@H](O)CC3)n2n1)-c1ccc(CNC)cc1
Show InChI InChI=1S/C23H32N6O/c1-3-4-13-25-23-26-15-20-21(17-7-5-16(6-8-17)14-24-2)27-22(29(20)28-23)18-9-11-19(30)12-10-18/h5-8,15,18-19,24,30H,3-4,9-14H2,1-2H3,(H,25,28)/t18-,19-
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Incyte Corporation

US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10005788 (2018)


BindingDB Entry DOI: 10.7270/Q21R6ST2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM401623
PNG
(US10005788, 4 (2nd peak))
Show SMILES CCCCNc1ncc2c(nc([C@@H]3CC[C@H](O)CC3)n2n1)-c1ccc2[nH]ccc2c1
PDB
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Incyte Corporation

US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10005788 (2018)


BindingDB Entry DOI: 10.7270/Q21R6ST2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM246883
PNG
(US10005788, 1 (2nd peak, cis-) | US10053465, 22 | ...)
Show SMILES O[C@H]1CCN(Cc2cc(O[C@H]3CC[C@H](CC3)N3CC(CC#N)(C3)n3cc(cn3)-c3ncnc4[nH]ccc34)nc(c2)C(F)(F)F)C1
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US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10005788 (2018)


BindingDB Entry DOI: 10.7270/Q21R6ST2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM401639
PNG
(US10005788, 13)
Show SMILES CCCCNc1ncc2c(nc(C[C@H]3CC[C@H](N)CC3)n2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C22H29FN6/c1-2-3-12-25-22-26-14-19-21(16-6-8-17(23)9-7-16)27-20(29(19)28-22)13-15-4-10-18(24)11-5-15/h6-9,14-15,18H,2-5,10-13,24H2,1H3,(H,25,28)/t15-,18-
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Incyte Corporation

US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10005788 (2018)


BindingDB Entry DOI: 10.7270/Q21R6ST2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM401637
PNG
(US10005788, 12 (1st peak))
Show SMILES CCCCNc1ncc2c(nc([C@H]3CC[C@H](O)CC3)n2n1)-c1ccc(CNC2CCCCC2)cc1
Show InChI InChI=1S/C28H40N6O/c1-2-3-17-29-28-31-19-25-26(32-27(34(25)33-28)22-13-15-24(35)16-14-22)21-11-9-20(10-12-21)18-30-23-7-5-4-6-8-23/h9-12,19,22-24,30,35H,2-8,13-18H2,1H3,(H,29,33)/t22-,24-
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Incyte Corporation

US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10005788 (2018)


BindingDB Entry DOI: 10.7270/Q21R6ST2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM401625
PNG
(US10005788, 5 (2nd peak, cis-))
Show SMILES CCCCNc1ncc2c(nc([C@H]3CC[C@H](O)CC3)n2n1)-c1ccc(cc1)N1CCNCC1
Show InChI InChI=1S/C25H35N7O/c1-2-3-12-27-25-28-17-22-23(18-4-8-20(9-5-18)31-15-13-26-14-16-31)29-24(32(22)30-25)19-6-10-21(33)11-7-19/h4-5,8-9,17,19,21,26,33H,2-3,6-7,10-16H2,1H3,(H,27,30)/t19-,21-
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Incyte Corporation

US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10005788 (2018)


BindingDB Entry DOI: 10.7270/Q21R6ST2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM401624
PNG
(US10005788, 5 (1st peak, trans-))
Show SMILES CCCCNc1ncc2c(nc([C@@H]3CC[C@H](O)CC3)n2n1)-c1ccc(cc1)N1CCNCC1
Show InChI InChI=1S/C25H35N7O/c1-2-3-12-27-25-28-17-22-23(18-4-8-20(9-5-18)31-15-13-26-14-16-31)29-24(32(22)30-25)19-6-10-21(33)11-7-19/h4-5,8-9,17,19,21,26,33H,2-3,6-7,10-16H2,1H3,(H,27,30)/t19-,21+
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Incyte Corporation

US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10005788 (2018)


BindingDB Entry DOI: 10.7270/Q21R6ST2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM401632
PNG
(US10005788, 9 (2nd peak))
Show SMILES CCCCNc1ncc2c(nc([C@H]3CC[C@H](O)CC3)n2n1)-c1cccc(NC(C)=O)c1
Show InChI InChI=1S/C23H30N6O2/c1-3-4-12-24-23-25-14-20-21(17-6-5-7-18(13-17)26-15(2)30)27-22(29(20)28-23)16-8-10-19(31)11-9-16/h5-7,13-14,16,19,31H,3-4,8-12H2,1-2H3,(H,24,28)(H,26,30)/t16-,19-
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Incyte Corporation

US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10005788 (2018)


BindingDB Entry DOI: 10.7270/Q21R6ST2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM401627
PNG
(US10005788, 6 (2nd peak, cis-))
Show SMILES CCCCNc1ncc2c(nc([C@@H]3CC[C@H](O)CC3)n2n1)-c1ccnc(c1)N1CCNCC1
Show InChI InChI=1S/C24H34N8O/c1-2-3-9-27-24-28-16-20-22(18-8-10-26-21(15-18)31-13-11-25-12-14-31)29-23(32(20)30-24)17-4-6-19(33)7-5-17/h8,10,15-17,19,25,33H,2-7,9,11-14H2,1H3,(H,27,30)/t17-,19+
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Incyte Corporation

US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10005788 (2018)


BindingDB Entry DOI: 10.7270/Q21R6ST2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM401624
PNG
(US10005788, 5 (1st peak, trans-))
Show SMILES CCCCNc1ncc2c(nc([C@@H]3CC[C@H](O)CC3)n2n1)-c1ccc(cc1)N1CCNCC1
Show InChI InChI=1S/C25H35N7O/c1-2-3-12-27-25-28-17-22-23(18-4-8-20(9-5-18)31-15-13-26-14-16-31)29-24(32(22)30-25)19-6-10-21(33)11-7-19/h4-5,8-9,17,19,21,26,33H,2-3,6-7,10-16H2,1H3,(H,27,30)/t19-,21+
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US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10005788 (2018)


BindingDB Entry DOI: 10.7270/Q21R6ST2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM246861
PNG
(3-[1-(6- chloropyridin-2- yl)pyrrolidin-3-yl]-3- [...)
Show SMILES Clc1cccc(n1)N1CCC(C1)C(CC#N)n1cc(cn1)-c1ncnc2[nH]ccc12
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Incyte Corporation

US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10005788 (2018)


BindingDB Entry DOI: 10.7270/Q21R6ST2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM401638
PNG
(US10005788, 12 (2nd peak))
Show SMILES CCCCNc1ncc2c(nc([C@@H]3CC[C@H](O)CC3)n2n1)-c1ccc(CNC2CCCCC2)cc1
Show InChI InChI=1S/C28H40N6O/c1-2-3-17-29-28-31-19-25-26(32-27(34(25)33-28)22-13-15-24(35)16-14-22)21-11-9-20(10-12-21)18-30-23-7-5-4-6-8-23/h9-12,19,22-24,30,35H,2-8,13-18H2,1H3,(H,29,33)/t22-,24+
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US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10005788 (2018)


BindingDB Entry DOI: 10.7270/Q21R6ST2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM401634
PNG
(US10005788, 10 (2nd peak))
Show SMILES CCCCNc1ncc2c(nc([C@@H]3CC[C@H](O)CC3)n2n1)-c1ccc(NC(C)=O)cc1
Show InChI InChI=1S/C23H30N6O2/c1-3-4-13-24-23-25-14-20-21(16-5-9-18(10-6-16)26-15(2)30)27-22(29(20)28-23)17-7-11-19(31)12-8-17/h5-6,9-10,14,17,19,31H,3-4,7-8,11-13H2,1-2H3,(H,24,28)(H,26,30)/t17-,19+
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US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10005788 (2018)


BindingDB Entry DOI: 10.7270/Q21R6ST2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM401626
PNG
(US10005788, 6 (1st peak, trans-))
Show SMILES CCCCNc1ncc2c(nc([C@H]3CC[C@H](O)CC3)n2n1)-c1ccnc(c1)N1CCNCC1
Show InChI InChI=1S/C24H34N8O/c1-2-3-9-27-24-28-16-20-22(18-8-10-26-21(15-18)31-13-11-25-12-14-31)29-23(32(20)30-24)17-4-6-19(33)7-5-17/h8,10,15-17,19,25,33H,2-7,9,11-14H2,1H3,(H,27,30)/t17-,19-
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Incyte Corporation

US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10005788 (2018)


BindingDB Entry DOI: 10.7270/Q21R6ST2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM246883
PNG
(US10005788, 1 (2nd peak, cis-) | US10053465, 22 | ...)
Show SMILES O[C@H]1CCN(Cc2cc(O[C@H]3CC[C@H](CC3)N3CC(CC#N)(C3)n3cc(cn3)-c3ncnc4[nH]ccc34)nc(c2)C(F)(F)F)C1
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US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10005788 (2018)


BindingDB Entry DOI: 10.7270/Q21R6ST2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM401629
PNG
(US10005788, 7 (2nd peak))
Show SMILES CCCCNc1ncc2c(nc([C@H]3CC[C@H](O)CC3)n2n1)-c1ccc(N2CCOCC2)c(F)c1
Show InChI InChI=1S/C25H33FN6O2/c1-2-3-10-27-25-28-16-22-23(29-24(32(22)30-25)17-4-7-19(33)8-5-17)18-6-9-21(20(26)15-18)31-11-13-34-14-12-31/h6,9,15-17,19,33H,2-5,7-8,10-14H2,1H3,(H,27,30)/t17-,19-
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Incyte Corporation

US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10005788 (2018)


BindingDB Entry DOI: 10.7270/Q21R6ST2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM246861
PNG
(3-[1-(6- chloropyridin-2- yl)pyrrolidin-3-yl]-3- [...)
Show SMILES Clc1cccc(n1)N1CCC(C1)C(CC#N)n1cc(cn1)-c1ncnc2[nH]ccc12
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Incyte Corporation

US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10005788 (2018)


BindingDB Entry DOI: 10.7270/Q21R6ST2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM401635
PNG
(US10005788, 11 (1st peak))
Show SMILES CCCCNc1ncc2c(nc([C@@H]3CC[C@H](O)CC3)n2n1)-c1ccc(CNC)cc1
Show InChI InChI=1S/C23H32N6O/c1-3-4-13-25-23-26-15-20-21(17-7-5-16(6-8-17)14-24-2)27-22(29(20)28-23)18-9-11-19(30)12-10-18/h5-8,15,18-19,24,30H,3-4,9-14H2,1-2H3,(H,25,28)/t18-,19+
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Incyte Corporation

US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10005788 (2018)


BindingDB Entry DOI: 10.7270/Q21R6ST2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM401622
PNG
(US10005788, 4 (1st peak))
Show SMILES CCCCNc1ncc2c(nc([C@H]3CC[C@H](O)CC3)n2n1)-c1ccc2[nH]ccc2c1
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Incyte Corporation

US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10005788 (2018)


BindingDB Entry DOI: 10.7270/Q21R6ST2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM401628
PNG
(US10005788, 7 (1st peak))
Show SMILES CCCNc1ncc2c(nc([C@@H]3CC[C@H](O)CC3)n2n1)-c1ccc(N2CCOCC2)c(F)c1
Show InChI InChI=1S/C24H31FN6O2/c1-2-9-26-24-27-15-21-22(28-23(31(21)29-24)16-3-6-18(32)7-4-16)17-5-8-20(19(25)14-17)30-10-12-33-13-11-30/h5,8,14-16,18,32H,2-4,6-7,9-13H2,1H3,(H,26,29)/t16-,18+
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Incyte Corporation

US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10005788 (2018)


BindingDB Entry DOI: 10.7270/Q21R6ST2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM401639
PNG
(US10005788, 13)
Show SMILES CCCCNc1ncc2c(nc(C[C@H]3CC[C@H](N)CC3)n2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C22H29FN6/c1-2-3-12-25-22-26-14-19-21(16-6-8-17(23)9-7-16)27-20(29(19)28-22)13-15-4-10-18(24)11-5-15/h6-9,14-15,18H,2-5,10-13,24H2,1H3,(H,25,28)/t15-,18-
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Incyte Corporation

US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10005788 (2018)


BindingDB Entry DOI: 10.7270/Q21R6ST2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM401636
PNG
(US10005788, 11 (2nd peak))
Show SMILES CCCCNc1ncc2c(nc([C@H]3CC[C@H](O)CC3)n2n1)-c1ccc(CNC)cc1
Show InChI InChI=1S/C23H32N6O/c1-3-4-13-25-23-26-15-20-21(17-7-5-16(6-8-17)14-24-2)27-22(29(20)28-23)18-9-11-19(30)12-10-18/h5-8,15,18-19,24,30H,3-4,9-14H2,1-2H3,(H,25,28)/t18-,19-
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Incyte Corporation

US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10005788 (2018)


BindingDB Entry DOI: 10.7270/Q21R6ST2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM401621
PNG
(US10005788, 3 (2nd peak, cis-))
Show SMILES CCCCNc1ncc2c(nc([C@H]3CC[C@H](O)CC3)n2n1)-c1ccc(CO)cc1
Show InChI InChI=1S/C22H29N5O2/c1-2-3-12-23-22-24-13-19-20(16-6-4-15(14-28)5-7-16)25-21(27(19)26-22)17-8-10-18(29)11-9-17/h4-7,13,17-18,28-29H,2-3,8-12,14H2,1H3,(H,23,26)/t17-,18-
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Incyte Corporation

US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10005788 (2018)


BindingDB Entry DOI: 10.7270/Q21R6ST2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM401640
PNG
(US10005788, 14)
Show SMILES N[C@H]1CC[C@H](Cc2nc(-c3ccc(F)cc3)c3cnc(NCCCc4ccccc4)nn23)CC1
Show InChI InChI=1S/C27H31FN6/c28-22-12-10-21(11-13-22)26-24-18-31-27(30-16-4-7-19-5-2-1-3-6-19)33-34(24)25(32-26)17-20-8-14-23(29)15-9-20/h1-3,5-6,10-13,18,20,23H,4,7-9,14-17,29H2,(H,30,33)/t20-,23-
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Incyte Corporation

US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10005788 (2018)


BindingDB Entry DOI: 10.7270/Q21R6ST2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM401635
PNG
(US10005788, 11 (1st peak))
Show SMILES CCCCNc1ncc2c(nc([C@@H]3CC[C@H](O)CC3)n2n1)-c1ccc(CNC)cc1
Show InChI InChI=1S/C23H32N6O/c1-3-4-13-25-23-26-15-20-21(17-7-5-16(6-8-17)14-24-2)27-22(29(20)28-23)18-9-11-19(30)12-10-18/h5-8,15,18-19,24,30H,3-4,9-14H2,1-2H3,(H,25,28)/t18-,19+
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Incyte Corporation

US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10005788 (2018)


BindingDB Entry DOI: 10.7270/Q21R6ST2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM401635
PNG
(US10005788, 11 (1st peak))
Show SMILES CCCCNc1ncc2c(nc([C@@H]3CC[C@H](O)CC3)n2n1)-c1ccc(CNC)cc1
Show InChI InChI=1S/C23H32N6O/c1-3-4-13-25-23-26-15-20-21(17-7-5-16(6-8-17)14-24-2)27-22(29(20)28-23)18-9-11-19(30)12-10-18/h5-8,15,18-19,24,30H,3-4,9-14H2,1-2H3,(H,25,28)/t18-,19+
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Incyte Corporation

US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10005788 (2018)


BindingDB Entry DOI: 10.7270/Q21R6ST2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM401629
PNG
(US10005788, 7 (2nd peak))
Show SMILES CCCCNc1ncc2c(nc([C@H]3CC[C@H](O)CC3)n2n1)-c1ccc(N2CCOCC2)c(F)c1
Show InChI InChI=1S/C25H33FN6O2/c1-2-3-10-27-25-28-16-22-23(29-24(32(22)30-25)17-4-7-19(33)8-5-17)18-6-9-21(20(26)15-18)31-11-13-34-14-12-31/h6,9,15-17,19,33H,2-5,7-8,10-14H2,1H3,(H,27,30)/t17-,19-
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Incyte Corporation

US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10005788 (2018)


BindingDB Entry DOI: 10.7270/Q21R6ST2
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%