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Patent code US10005792

Compile Data Set for Download or QSAR
Found 140 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401715
PNG
(US10005792, Compound 135 | US10005792, Compound 77)
Show SMILES CCOc1cc(ccc1C(=O)NC[C@@H](O)CNC1Cc2ccccc2C1)C(=O)N1C2CCC1COC2
Show InChI InChI=1S/C28H35N3O5/c1-2-36-26-13-20(28(34)31-22-8-9-23(31)17-35-16-22)7-10-25(26)27(33)30-15-24(32)14-29-21-11-18-5-3-4-6-19(18)12-21/h3-7,10,13,21-24,29,32H,2,8-9,11-12,14-17H2,1H3,(H,30,33)/t22?,23?,24-/m0/s1
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n/an/a 15n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401715
PNG
(US10005792, Compound 135 | US10005792, Compound 77)
Show SMILES CCOc1cc(ccc1C(=O)NC[C@@H](O)CNC1Cc2ccccc2C1)C(=O)N1C2CCC1COC2
Show InChI InChI=1S/C28H35N3O5/c1-2-36-26-13-20(28(34)31-22-8-9-23(31)17-35-16-22)7-10-25(26)27(33)30-15-24(32)14-29-21-11-18-5-3-4-6-19(18)12-21/h3-7,10,13,21-24,29,32H,2,8-9,11-12,14-17H2,1H3,(H,30,33)/t22?,23?,24-/m0/s1
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n/an/a 29n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401764
PNG
(US10005792, Compound 123)
Show SMILES CCOc1cc(ccc1C(=O)NC[C@@H](O)CNC1Cc2ccccc2C1)C(=O)N1CCOC[C@H]1C
Show InChI InChI=1S/C27H35N3O5/c1-3-35-25-14-21(27(33)30-10-11-34-17-18(30)2)8-9-24(25)26(32)29-16-23(31)15-28-22-12-19-6-4-5-7-20(19)13-22/h4-9,14,18,22-23,28,31H,3,10-13,15-17H2,1-2H3,(H,29,32)/t18-,23+/m1/s1
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n/an/a 40n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401765
PNG
(US10005792, Compound 124)
Show SMILES CCOc1cc(ccc1C(=O)NC[C@@H](O)CNC1Cc2ccccc2C1)C(=O)N1CCOC[C@@H]1CC
Show InChI InChI=1S/C28H37N3O5/c1-3-23-18-35-12-11-31(23)28(34)21-9-10-25(26(15-21)36-4-2)27(33)30-17-24(32)16-29-22-13-19-7-5-6-8-20(19)14-22/h5-10,15,22-24,29,32H,3-4,11-14,16-18H2,1-2H3,(H,30,33)/t23-,24-/m0/s1
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n/an/a 48n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401672
PNG
(US10005792, Compound 35)
Show SMILES CC(=O)N1CCC(CC1)Nc1cc(ccn1)C(=O)NCC(O)CNC1Cc2ccccc2C1
Show InChI InChI=1S/C25H33N5O3/c1-17(31)30-10-7-21(8-11-30)29-24-14-20(6-9-26-24)25(33)28-16-23(32)15-27-22-12-18-4-2-3-5-19(18)13-22/h2-6,9,14,21-23,27,32H,7-8,10-13,15-16H2,1H3,(H,26,29)(H,28,33)
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n/an/a 50n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401741
PNG
(US10005792, Compound 103 | US10005792, Compound 13...)
Show SMILES O[C@@H](CNC1Cc2ccccc2C1)CNC(=O)c1ccc(cc1)C(=O)N1C2CCC1COC2
Show InChI InChI=1S/C26H31N3O4/c30-24(13-27-21-11-19-3-1-2-4-20(19)12-21)14-28-25(31)17-5-7-18(8-6-17)26(32)29-22-9-10-23(29)16-33-15-22/h1-8,21-24,27,30H,9-16H2,(H,28,31)/t22?,23?,24-/m0/s1
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n/an/a 50n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401677
PNG
(US10005792, Compound 40)
Show SMILES OC(CNC1Cc2ccccc2C1)CNC(=O)c1ccc(cc1)C(=O)N1C2CCC1COC2
Show InChI InChI=1S/C26H31N3O4/c30-24(13-27-21-11-19-3-1-2-4-20(19)12-21)14-28-25(31)17-5-7-18(8-6-17)26(32)29-22-9-10-23(29)16-33-15-22/h1-8,21-24,27,30H,9-16H2,(H,28,31)
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n/an/a 57n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401713
PNG
(US10005792, Compound 75)
Show SMILES CCOc1cc(ccc1C(=O)NC[C@@H](O)CNC1Cc2ccccc2C1)C(=O)N1CCOCC1
Show InChI InChI=1S/C26H33N3O5/c1-2-34-24-15-20(26(32)29-9-11-33-12-10-29)7-8-23(24)25(31)28-17-22(30)16-27-21-13-18-5-3-4-6-19(18)14-21/h3-8,15,21-22,27,30H,2,9-14,16-17H2,1H3,(H,28,31)/t22-/m0/s1
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n/an/a 64n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401755
PNG
(US10005792, Compound 114)
Show SMILES CCOc1cc(ccc1C(=O)NC[C@@H](O)CNC1Cc2ccccc2C1)C(=O)N1CCS(=O)(=O)CC1
Show InChI InChI=1S/C26H33N3O6S/c1-2-35-24-15-20(26(32)29-9-11-36(33,34)12-10-29)7-8-23(24)25(31)28-17-22(30)16-27-21-13-18-5-3-4-6-19(18)14-21/h3-8,15,21-22,27,30H,2,9-14,16-17H2,1H3,(H,28,31)/t22-/m0/s1
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n/an/a 66n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401673
PNG
(US10005792, Compound 37)
Show SMILES C[C@@H]1COCCN1C(=O)c1ccc(cc1)C(=O)NC[C@@H](O)CNC1Cc2ccccc2C1
Show InChI InChI=1S/C25H31N3O4/c1-17-16-32-11-10-28(17)25(31)19-8-6-18(7-9-19)24(30)27-15-23(29)14-26-22-12-20-4-2-3-5-21(20)13-22/h2-9,17,22-23,26,29H,10-16H2,1H3,(H,27,30)/t17-,23+/m1/s1
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n/an/a 95n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401693
PNG
(US10005792, Compound 56)
Show SMILES CC(=O)N1CCC(CC1)Oc1cc(ccn1)C(=O)NC[C@@H](O)CNC1Cc2ccccc2C1
Show InChI InChI=1S/C25H32N4O4/c1-17(30)29-10-7-23(8-11-29)33-24-14-20(6-9-26-24)25(32)28-16-22(31)15-27-21-12-18-4-2-3-5-19(18)13-21/h2-6,9,14,21-23,27,31H,7-8,10-13,15-16H2,1H3,(H,28,32)/t22-/m0/s1
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n/an/a 98n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401676
PNG
(US10005792, Compound 39)
Show SMILES OC(CNC1Cc2ccccc2C1)CNC(=O)c1ccc(cc1)C(=O)N1CC2CCC(C1)O2
Show InChI InChI=1S/C26H31N3O4/c30-22(13-27-21-11-19-3-1-2-4-20(19)12-21)14-28-25(31)17-5-7-18(8-6-17)26(32)29-15-23-9-10-24(16-29)33-23/h1-8,21-24,27,30H,9-16H2,(H,28,31)
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n/an/a 120n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401741
PNG
(US10005792, Compound 103 | US10005792, Compound 13...)
Show SMILES O[C@@H](CNC1Cc2ccccc2C1)CNC(=O)c1ccc(cc1)C(=O)N1C2CCC1COC2
Show InChI InChI=1S/C26H31N3O4/c30-24(13-27-21-11-19-3-1-2-4-20(19)12-21)14-28-25(31)17-5-7-18(8-6-17)26(32)29-22-9-10-23(29)16-33-15-22/h1-8,21-24,27,30H,9-16H2,(H,28,31)/t22?,23?,24-/m0/s1
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n/an/a 120n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401762
PNG
(US10005792, Compound 121)
Show SMILES O[C@@H](CNC1Cc2ccccc2C1)CNC(=O)c1ccc(cc1Cl)C(=O)N1C2CCC1COC2
Show InChI InChI=1S/C26H30ClN3O4/c27-24-11-18(26(33)30-20-6-7-21(30)15-34-14-20)5-8-23(24)25(32)29-13-22(31)12-28-19-9-16-3-1-2-4-17(16)10-19/h1-5,8,11,19-22,28,31H,6-7,9-10,12-15H2,(H,29,32)/t20?,21?,22-/m0/s1
PDB

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n/an/a 130n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401774
PNG
(US10005792, Compound 133)
Show SMILES O[C@@H](CNC1Cc2ccccc2C1)CNC(=O)c1ccc(cc1F)C(=O)N1C2CCC1COC2
Show InChI InChI=1S/C26H30FN3O4/c27-24-11-18(26(33)30-20-6-7-21(30)15-34-14-20)5-8-23(24)25(32)29-13-22(31)12-28-19-9-16-3-1-2-4-17(16)10-19/h1-5,8,11,19-22,28,31H,6-7,9-10,12-15H2,(H,29,32)/t20?,21?,22-/m0/s1
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n/an/a 131n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401768
PNG
(US10005792, Compound 127)
Show SMILES CCOc1cc(ccc1C(=O)NC[C@@H](O)CNC1Cc2ccccc2C1)C(=O)N1C[C@H]2C[C@@H]1CO2
Show InChI InChI=1S/C27H33N3O5/c1-2-34-25-11-19(27(33)30-15-23-12-21(30)16-35-23)7-8-24(25)26(32)29-14-22(31)13-28-20-9-17-5-3-4-6-18(17)10-20/h3-8,11,20-23,28,31H,2,9-10,12-16H2,1H3,(H,29,32)/t21-,22+,23-/m1/s1
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n/an/a 137n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401679
PNG
(US10005792, Compound 42)
Show SMILES CC(=O)N1CCC(CC1)Nc1cccc(c1)C(=O)NC[C@@H](O)CNC1Cc2ccccc2C1
Show InChI InChI=1S/C26H34N4O3/c1-18(31)30-11-9-22(10-12-30)29-23-8-4-7-21(15-23)26(33)28-17-25(32)16-27-24-13-19-5-2-3-6-20(19)14-24/h2-8,15,22,24-25,27,29,32H,9-14,16-17H2,1H3,(H,28,33)/t25-/m0/s1
PDB

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n/an/a 137n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401672
PNG
(US10005792, Compound 35)
Show SMILES CC(=O)N1CCC(CC1)Nc1cc(ccn1)C(=O)NCC(O)CNC1Cc2ccccc2C1
Show InChI InChI=1S/C25H33N5O3/c1-17(31)30-10-7-21(8-11-30)29-24-14-20(6-9-26-24)25(33)28-16-23(32)15-27-22-12-18-4-2-3-5-19(18)13-22/h2-6,9,14,21-23,27,32H,7-8,10-13,15-16H2,1H3,(H,26,29)(H,28,33)
PDB

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n/an/a 155n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401708
PNG
(US10005792, Compound 70)
Show SMILES CC[C@H]1COCCN1C(=O)c1ccc(cc1)C(=O)NC[C@@H](O)CNC1Cc2ccccc2C1
Show InChI InChI=1S/C26H33N3O4/c1-2-23-17-33-12-11-29(23)26(32)19-9-7-18(8-10-19)25(31)28-16-24(30)15-27-22-13-20-5-3-4-6-21(20)14-22/h3-10,22-24,27,30H,2,11-17H2,1H3,(H,28,31)/t23-,24-/m0/s1
PDB

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n/an/a 157n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401678
PNG
(US10005792, Compound 41)
Show SMILES CC1(C)CN(CCO1)C(=O)c1ccc(cc1)C(=O)NCC(O)CNC1Cc2ccccc2C1
Show InChI InChI=1S/C26H33N3O4/c1-26(2)17-29(11-12-33-26)25(32)19-9-7-18(8-10-19)24(31)28-16-23(30)15-27-22-13-20-5-3-4-6-21(20)14-22/h3-10,22-23,27,30H,11-17H2,1-2H3,(H,28,31)
PDB

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n/an/a 157n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401673
PNG
(US10005792, Compound 37)
Show SMILES C[C@@H]1COCCN1C(=O)c1ccc(cc1)C(=O)NC[C@@H](O)CNC1Cc2ccccc2C1
Show InChI InChI=1S/C25H31N3O4/c1-17-16-32-11-10-28(17)25(31)19-8-6-18(7-9-19)24(30)27-15-23(29)14-26-22-12-20-4-2-3-5-21(20)13-22/h2-9,17,22-23,26,29H,10-16H2,1H3,(H,27,30)/t17-,23+/m1/s1
PDB

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n/an/a 163n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401690
PNG
(US10005792, Compound 53)
Show SMILES CC(=O)N1CCC(CC1)Oc1cncc(c1)C(=O)NCC(O)CNC1Cc2ccccc2C1
Show InChI InChI=1S/C25H32N4O4/c1-17(30)29-8-6-23(7-9-29)33-24-12-20(13-26-16-24)25(32)28-15-22(31)14-27-21-10-18-4-2-3-5-19(18)11-21/h2-5,12-13,16,21-23,27,31H,6-11,14-15H2,1H3,(H,28,32)
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CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401763
PNG
(US10005792, Compound 122)
Show SMILES CCOc1cc(C(=O)N2CCOCC2)c(C)cc1C(=O)NC[C@@H](O)CNC1Cc2ccccc2C1
Show InChI InChI=1S/C27H35N3O5/c1-3-35-25-15-23(27(33)30-8-10-34-11-9-30)18(2)12-24(25)26(32)29-17-22(31)16-28-21-13-19-6-4-5-7-20(19)14-21/h4-7,12,15,21-22,28,31H,3,8-11,13-14,16-17H2,1-2H3,(H,29,32)/t22-/m0/s1
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CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401751
PNG
(US10005792, Compound 110)
Show SMILES COc1ccc(CN(C[C@H](O)CNC(=O)c2ccnc(NC3CN(C3)C(C)=O)c2)C2Cc3ccccc3C2)c(OC)c1
Show InChI InChI=1S/C32H39N5O5/c1-21(38)36-18-26(19-36)35-31-14-24(10-11-33-31)32(40)34-16-28(39)20-37(27-12-22-6-4-5-7-23(22)13-27)17-25-8-9-29(41-2)15-30(25)42-3/h4-11,14-15,26-28,39H,12-13,16-20H2,1-3H3,(H,33,35)(H,34,40)/t28-/m1/s1
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CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401658
PNG
(US10005792, Compound 22)
Show SMILES OC(CNC1Cc2ccccc2C1)CNC(=O)c1ccc(cc1)C(=O)N1CCCCC1
Show InChI InChI=1S/C25H31N3O3/c29-23(16-26-22-14-20-6-2-3-7-21(20)15-22)17-27-24(30)18-8-10-19(11-9-18)25(31)28-12-4-1-5-13-28/h2-3,6-11,22-23,26,29H,1,4-5,12-17H2,(H,27,30)
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CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401698
PNG
(US10005792, Compound 61)
Show SMILES OCC1CCN(CC1)C(=O)c1ccc(cc1)C(=O)NC[C@@H](O)CNC1Cc2ccccc2C1
Show InChI InChI=1S/C26H33N3O4/c30-17-18-9-11-29(12-10-18)26(33)20-7-5-19(6-8-20)25(32)28-16-24(31)15-27-23-13-21-3-1-2-4-22(21)14-23/h1-8,18,23-24,27,30-31H,9-17H2,(H,28,32)/t24-/m0/s1
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CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401743
PNG
(US10005792, Compound 105)
Show SMILES O[C@@H](CNC1Cc2ccccc2C1)CNC(=O)c1ccc(cc1)C(=O)N1CC2CCC(C1)O2
Show InChI InChI=1S/C26H31N3O4/c30-22(13-27-21-11-19-3-1-2-4-20(19)12-21)14-28-25(31)17-5-7-18(8-6-17)26(32)29-15-23-9-10-24(16-29)33-23/h1-8,21-24,27,30H,9-16H2,(H,28,31)/t22-,23?,24?/m0/s1
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CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401714
PNG
(US10005792, Compound 76)
Show SMILES CCOc1cc(ccc1C(=O)NC[C@@H](O)CNC1Cc2ccccc2C1)C(=O)N1CCCC1
Show InChI InChI=1S/C26H33N3O4/c1-2-33-24-15-20(26(32)29-11-5-6-12-29)9-10-23(24)25(31)28-17-22(30)16-27-21-13-18-7-3-4-8-19(18)14-21/h3-4,7-10,15,21-22,27,30H,2,5-6,11-14,16-17H2,1H3,(H,28,31)/t22-/m0/s1
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CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401675
PNG
(US10005792, Compound 38)
Show SMILES C[C@H]1COCCN1C(=O)c1ccc(cc1)C(=O)NC[C@@H](O)CNC1Cc2ccccc2C1
Show InChI InChI=1S/C25H31N3O4/c1-17-16-32-11-10-28(17)25(31)19-8-6-18(7-9-19)24(30)27-15-23(29)14-26-22-12-20-4-2-3-5-21(20)13-22/h2-9,17,22-23,26,29H,10-16H2,1H3,(H,27,30)/t17-,23-/m0/s1
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CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401652
PNG
(US10005792, Compound 15)
Show SMILES O[C@@H](CNC1Cc2ccccc2C1)CNC(=O)c1ccc(cc1)C(=O)N1CCOCC1
Show InChI InChI=1S/C24H29N3O4/c28-22(15-25-21-13-19-3-1-2-4-20(19)14-21)16-26-23(29)17-5-7-18(8-6-17)24(30)27-9-11-31-12-10-27/h1-8,21-22,25,28H,9-16H2,(H,26,29)/t22-/m0/s1
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CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401767
PNG
(US10005792, Compound 126)
Show SMILES CCOc1cc(ncc1C(=O)NC[C@@H](O)CNC1Cc2ccccc2C1)C(=O)N1C2CCC1COC2
Show InChI InChI=1S/C27H34N4O5/c1-2-36-25-11-24(27(34)31-20-7-8-21(31)16-35-15-20)29-14-23(25)26(33)30-13-22(32)12-28-19-9-17-5-3-4-6-18(17)10-19/h3-6,11,14,19-22,28,32H,2,7-10,12-13,15-16H2,1H3,(H,30,33)/t20?,21?,22-/m0/s1
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CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401727
PNG
(US10005792, Compound 88)
Show SMILES O[C@@H](CNC1Cc2ccccc2C1)CNC(=O)c1ccc(cc1)C(=O)N1CCC2(CCO2)CC1
Show InChI InChI=1S/C27H33N3O4/c31-24(17-28-23-15-21-3-1-2-4-22(21)16-23)18-29-25(32)19-5-7-20(8-6-19)26(33)30-12-9-27(10-13-30)11-14-34-27/h1-8,23-24,28,31H,9-18H2,(H,29,32)/t24-/m0/s1
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CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401709
PNG
(US10005792, Compound 71)
Show SMILES CC[C@@H]1COCCN1C(=O)c1ccc(cc1)C(=O)NC[C@@H](O)CNC1Cc2ccccc2C1
Show InChI InChI=1S/C26H33N3O4/c1-2-23-17-33-12-11-29(23)26(32)19-9-7-18(8-10-19)25(31)28-16-24(30)15-27-22-13-20-5-3-4-6-21(20)14-22/h3-10,22-24,27,30H,2,11-17H2,1H3,(H,28,31)/t23-,24+/m1/s1
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CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401655
PNG
(US10005792, Compound 18)
Show SMILES Cn1cc(Oc2ccc(cc2)C(=O)NC[C@@H](O)CNC2Cc3ccccc3C2)cn1
Show InChI InChI=1S/C23H26N4O3/c1-27-15-22(14-26-27)30-21-8-6-16(7-9-21)23(29)25-13-20(28)12-24-19-10-17-4-2-3-5-18(17)11-19/h2-9,14-15,19-20,24,28H,10-13H2,1H3,(H,25,29)/t20-/m0/s1
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CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401775
PNG
(US10005792, Compound 134)
Show SMILES COc1cc(ccc1C(=O)NC[C@@H](O)CNC1Cc2ccccc2C1)C(=O)N1C2CCC1COC2
Show InChI InChI=1S/C27H33N3O5/c1-34-25-12-19(27(33)30-21-7-8-22(30)16-35-15-21)6-9-24(25)26(32)29-14-23(31)13-28-20-10-17-4-2-3-5-18(17)11-20/h2-6,9,12,20-23,28,31H,7-8,10-11,13-16H2,1H3,(H,29,32)/t21?,22?,23-/m0/s1
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CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401718
PNG
(US10005792, Compound 80)
Show SMILES COCC1CCCCN1C(=O)c1ccc(cc1)C(=O)NC[C@@H](O)CNC1Cc2ccccc2C1
Show InChI InChI=1S/C27H35N3O4/c1-34-18-24-8-4-5-13-30(24)27(33)20-11-9-19(10-12-20)26(32)29-17-25(31)16-28-23-14-21-6-2-3-7-22(21)15-23/h2-3,6-7,9-12,23-25,28,31H,4-5,8,13-18H2,1H3,(H,29,32)/t24?,25-/m0/s1
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CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401645
PNG
(US10005792, Compound 8)
Show SMILES Cc1nonc1COc1ccc(cc1)C(=O)NC[C@H](O)CNC1Cc2ccccc2C1
Show InChI InChI=1S/C23H26N4O4/c1-15-22(27-31-26-15)14-30-21-8-6-16(7-9-21)23(29)25-13-20(28)12-24-19-10-17-4-2-3-5-18(17)11-19/h2-9,19-20,24,28H,10-14H2,1H3,(H,25,29)/t20-/m1/s1
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CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401757
PNG
(US10005792, Compound 116)
Show SMILES CCOc1cc(ccc1C(=O)NC[C@@H](O)CNC1Cc2ccccc2C1)-c1nnc(C)o1
Show InChI InChI=1S/C24H28N4O4/c1-3-31-22-12-18(24-28-27-15(2)32-24)8-9-21(22)23(30)26-14-20(29)13-25-19-10-16-6-4-5-7-17(16)11-19/h4-9,12,19-20,25,29H,3,10-11,13-14H2,1-2H3,(H,26,30)/t20-/m0/s1
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CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401737
PNG
(US10005792, Compound 98)
Show SMILES COc1cc(ccc1C(=O)NC[C@@H](O)CNC1Cc2ccccc2C1)C(=O)N1CCOCC1
Show InChI InChI=1S/C25H31N3O5/c1-32-23-14-19(25(31)28-8-10-33-11-9-28)6-7-22(23)24(30)27-16-21(29)15-26-20-12-17-4-2-3-5-18(17)13-20/h2-7,14,20-21,26,29H,8-13,15-16H2,1H3,(H,27,30)/t21-/m0/s1
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CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401653
PNG
(US10005792, Compound 16)
Show SMILES O[C@@H](CNC1Cc2ccccc2C1)CNC(=O)c1ccc(nc1)N1CCOCC1
Show InChI InChI=1S/C22H28N4O3/c27-20(14-23-19-11-16-3-1-2-4-17(16)12-19)15-25-22(28)18-5-6-21(24-13-18)26-7-9-29-10-8-26/h1-6,13,19-20,23,27H,7-12,14-15H2,(H,25,28)/t20-/m0/s1
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CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401756
PNG
(US10005792, Compound 115)
Show SMILES CCOc1nc(ccc1C(=O)NC[C@@H](O)CNC1Cc2ccccc2C1)C(=O)N1C2CCC1COC2
Show InChI InChI=1S/C27H34N4O5/c1-2-36-26-23(9-10-24(30-26)27(34)31-20-7-8-21(31)16-35-15-20)25(33)29-14-22(32)13-28-19-11-17-5-3-4-6-18(17)12-19/h3-6,9-10,19-22,28,32H,2,7-8,11-16H2,1H3,(H,29,33)/t20?,21?,22-/m0/s1
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CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401618
PNG
(US10005792, Compound 3)
Show SMILES O[C@H](CNC1Cc2ccccc2C1)CNC(=O)c1cnc(s1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C23H22F3N3O2S/c24-23(25,26)17-7-5-14(6-8-17)22-29-13-20(32-22)21(31)28-12-19(30)11-27-18-9-15-3-1-2-4-16(15)10-18/h1-8,13,18-19,27,30H,9-12H2,(H,28,31)/t19-/m1/s1
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CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401675
PNG
(US10005792, Compound 38)
Show SMILES C[C@H]1COCCN1C(=O)c1ccc(cc1)C(=O)NC[C@@H](O)CNC1Cc2ccccc2C1
Show InChI InChI=1S/C25H31N3O4/c1-17-16-32-11-10-28(17)25(31)19-8-6-18(7-9-19)24(30)27-15-23(29)14-26-22-12-20-4-2-3-5-21(20)13-22/h2-9,17,22-23,26,29H,10-16H2,1H3,(H,27,30)/t17-,23-/m0/s1
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CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401617
PNG
(US10005792, Compound 2)
Show SMILES OC(CNC1Cc2ccccc2C1)CNC(=O)c1ccc(cc1)C(=O)N1CCOCC1
Show InChI InChI=1S/C24H29N3O4/c28-22(15-25-21-13-19-3-1-2-4-20(19)14-21)16-26-23(29)17-5-7-18(8-6-17)24(30)27-9-11-31-12-10-27/h1-8,21-22,25,28H,9-16H2,(H,26,29)
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CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401710
PNG
(US10005792, Compound 72)
Show SMILES CC1(C)CN(CCO1)C(=O)c1ccc(cc1)C(=O)NC[C@@H](O)CNC1Cc2ccccc2C1
Show InChI InChI=1S/C26H33N3O4/c1-26(2)17-29(11-12-33-26)25(32)19-9-7-18(8-10-19)24(31)28-16-23(30)15-27-22-13-20-5-3-4-6-21(20)14-22/h3-10,22-23,27,30H,11-17H2,1-2H3,(H,28,31)/t23-/m0/s1
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n/an/a 341n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401681
PNG
(US10005792, Compound 44)
Show SMILES OC(CNC1Cc2ccccc2C1)CNC(=O)c1ccnc(NC2CCCC2)c1
Show InChI InChI=1S/C23H30N4O2/c28-21(14-25-20-11-16-5-1-2-6-17(16)12-20)15-26-23(29)18-9-10-24-22(13-18)27-19-7-3-4-8-19/h1-2,5-6,9-10,13,19-21,25,28H,3-4,7-8,11-12,14-15H2,(H,24,27)(H,26,29)
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CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401660
PNG
(US10005792, Compound 24)
Show SMILES OC(CNC1Cc2ccccc2C1)CNC(=O)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C25H26N2O2/c28-24(16-26-23-14-21-8-4-5-9-22(21)15-23)17-27-25(29)20-12-10-19(11-13-20)18-6-2-1-3-7-18/h1-13,23-24,26,28H,14-17H2,(H,27,29)
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CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401664
PNG
(US10005792, Compound 27)
Show SMILES OC(CNC1Cc2ccccc2C1)CNC(=O)c1ccc(cc1F)C(=O)N1CCOCC1
Show InChI InChI=1S/C24H28FN3O4/c25-22-13-18(24(31)28-7-9-32-10-8-28)5-6-21(22)23(30)27-15-20(29)14-26-19-11-16-3-1-2-4-17(16)12-19/h1-6,13,19-20,26,29H,7-12,14-15H2,(H,27,30)
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CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401651
PNG
(US10005792, Compound 14)
Show SMILES O[C@@H](CNC1Cc2ccccc2C1)CNC(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C19H21ClN2O2/c20-16-7-5-13(6-8-16)19(24)22-12-18(23)11-21-17-9-14-3-1-2-4-15(14)10-17/h1-8,17-18,21,23H,9-12H2,(H,22,24)/t18-/m0/s1
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CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401692
PNG
(US10005792, Compound 55)
Show SMILES CC(=O)N1CCC(CC1)Oc1cc(ccn1)C(=O)NC[C@H](O)CNC1Cc2ccccc2C1
Show InChI InChI=1S/C25H32N4O4/c1-17(30)29-10-7-23(8-11-29)33-24-14-20(6-9-26-24)25(32)28-16-22(31)15-27-21-12-18-4-2-3-5-19(18)13-21/h2-6,9,14,21-23,27,31H,7-8,10-13,15-16H2,1H3,(H,28,32)/t22-/m1/s1
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CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401739
PNG
(US10005792, Compound 101)
Show SMILES C[C@@H]1COC[C@@H](C)N1C(=O)c1ccc(cc1)C(=O)NCC(O)CNC1Cc2ccccc2C1
Show InChI InChI=1S/C26H33N3O4/c1-17-15-33-16-18(2)29(17)26(32)20-9-7-19(8-10-20)25(31)28-14-24(30)13-27-23-11-21-5-3-4-6-22(21)12-23/h3-10,17-18,23-24,27,30H,11-16H2,1-2H3,(H,28,31)/t17-,18-,24?/m1/s1
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CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401687
PNG
(US10005792, Compound 50)
Show SMILES CC(=O)N1CCC(CC1)Oc1cc(ccn1)C(=O)NCC(O)CNC1Cc2ccccc2C1
Show InChI InChI=1S/C25H32N4O4/c1-17(30)29-10-7-23(8-11-29)33-24-14-20(6-9-26-24)25(32)28-16-22(31)15-27-21-12-18-4-2-3-5-19(18)13-21/h2-6,9,14,21-23,27,31H,7-8,10-13,15-16H2,1H3,(H,28,32)
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CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401740
PNG
(US10005792, Compound 102)
Show SMILES CC1(C)COCCN1C(=O)c1ccc(cc1)C(=O)NC[C@@H](O)CNC1Cc2ccccc2C1
Show InChI InChI=1S/C26H33N3O4/c1-26(2)17-33-12-11-29(26)25(32)19-9-7-18(8-10-19)24(31)28-16-23(30)15-27-22-13-20-5-3-4-6-21(20)14-22/h3-10,22-23,27,30H,11-17H2,1-2H3,(H,28,31)/t23-/m0/s1
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CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401696
PNG
(US10005792, Compound 59)
Show SMILES CC(=O)N1CCC(CC1)Nc1cc(ncn1)C(=O)NCC(O)CNC1Cc2ccccc2C1
Show InChI InChI=1S/C24H32N6O3/c1-16(31)30-8-6-19(7-9-30)29-23-12-22(27-15-28-23)24(33)26-14-21(32)13-25-20-10-17-4-2-3-5-18(17)11-20/h2-5,12,15,19-21,25,32H,6-11,13-14H2,1H3,(H,26,33)(H,27,28,29)
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CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401732
PNG
(US10005792, Compound 93)
Show SMILES OC(CNC1Cc2ccccc2C1)CNC(=O)c1ccc2CCN(Cc2c1)C(=O)CC1CC1
Show InChI InChI=1S/C27H33N3O3/c31-25(15-28-24-13-20-3-1-2-4-21(20)14-24)16-29-27(33)22-8-7-19-9-10-30(17-23(19)12-22)26(32)11-18-5-6-18/h1-4,7-8,12,18,24-25,28,31H,5-6,9-11,13-17H2,(H,29,33)
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CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401742
PNG
(US10005792, Compound 104)
Show SMILES O[C@@H](CNC1Cc2ccccc2C1)CNC(=O)c1ccc(cc1)C(=O)N1CCOCC11CCC1
Show InChI InChI=1S/C27H33N3O4/c31-24(16-28-23-14-21-4-1-2-5-22(21)15-23)17-29-25(32)19-6-8-20(9-7-19)26(33)30-12-13-34-18-27(30)10-3-11-27/h1-2,4-9,23-24,28,31H,3,10-18H2,(H,29,32)/t24-/m0/s1
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CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401723
PNG
(US10005792, Compound 84)
Show SMILES CC(=O)N1CCN(CC1)C(=O)c1ccc(cc1)C(=O)NCC(O)CNC1Cc2ccccc2C1
Show InChI InChI=1S/C26H32N4O4/c1-18(31)29-10-12-30(13-11-29)26(34)20-8-6-19(7-9-20)25(33)28-17-24(32)16-27-23-14-21-4-2-3-5-22(21)15-23/h2-9,23-24,27,32H,10-17H2,1H3,(H,28,33)
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CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401770
PNG
(US10005792, Compound 129)
Show SMILES CCOc1cc(CC(=O)N2C3CCC2COC3)ccc1C(=O)NC[C@@H](O)CNC1Cc2ccccc2C1
Show InChI InChI=1S/C29H37N3O5/c1-2-37-27-11-19(12-28(34)32-23-8-9-24(32)18-36-17-23)7-10-26(27)29(35)31-16-25(33)15-30-22-13-20-5-3-4-6-21(20)14-22/h3-7,10-11,22-25,30,33H,2,8-9,12-18H2,1H3,(H,31,35)/t23?,24?,25-/m0/s1
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CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401654
PNG
(US10005792, Compound 17)
Show SMILES Cc1nnc(o1)-c1ccc(cc1)C(=O)NC[C@@H](O)CNC1Cc2ccccc2C1
Show InChI InChI=1S/C22H24N4O3/c1-14-25-26-22(29-14)16-8-6-15(7-9-16)21(28)24-13-20(27)12-23-19-10-17-4-2-3-5-18(17)11-19/h2-9,19-20,23,27H,10-13H2,1H3,(H,24,28)/t20-/m0/s1
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CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401697
PNG
(US10005792, Compound 60)
Show SMILES O[C@@H](CNC1Cc2ccccc2C1)CNC(=O)c1ccc(cc1)C(=O)N1CCC(O)CC1
Show InChI InChI=1S/C25H31N3O4/c29-22-9-11-28(12-10-22)25(32)18-7-5-17(6-8-18)24(31)27-16-23(30)15-26-21-13-19-3-1-2-4-20(19)14-21/h1-8,21-23,26,29-30H,9-16H2,(H,27,31)/t23-/m0/s1
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CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401650
PNG
(US10005792, Compound 13)
Show SMILES Cn1cc(Oc2ccc(cc2)C(=O)NC[C@H](O)CNC2Cc3ccccc3C2)cn1
Show InChI InChI=1S/C23H26N4O3/c1-27-15-22(14-26-27)30-21-8-6-16(7-9-21)23(29)25-13-20(28)12-24-19-10-17-4-2-3-5-18(17)11-19/h2-9,14-15,19-20,24,28H,10-13H2,1H3,(H,25,29)/t20-/m1/s1
PDB

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CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401725
PNG
(US10005792, Compound 86)
Show SMILES COC1CCN(CC1)C(=O)c1ccc(cc1)C(=O)NC[C@@H](O)CNC1Cc2ccccc2C1
Show InChI InChI=1S/C26H33N3O4/c1-33-24-10-12-29(13-11-24)26(32)19-8-6-18(7-9-19)25(31)28-17-23(30)16-27-22-14-20-4-2-3-5-21(20)15-22/h2-9,22-24,27,30H,10-17H2,1H3,(H,28,31)/t23-/m0/s1
PDB

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CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401649
PNG
(US10005792, Compound 12)
Show SMILES Cc1nnc(o1)-c1ccc(cc1)C(=O)NC[C@H](O)CNC1Cc2ccccc2C1
Show InChI InChI=1S/C22H24N4O3/c1-14-25-26-22(29-14)16-8-6-15(7-9-16)21(28)24-13-20(27)12-23-19-10-17-4-2-3-5-18(17)11-19/h2-9,19-20,23,27H,10-13H2,1H3,(H,24,28)/t20-/m1/s1
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CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401783
PNG
(US10005792, Compound 141)
Show SMILES CCOc1cc(C(=O)N2C3CCC2COC3)c(F)cc1C(=O)NC[C@@H](O)CNC1Cc2ccccc2C1
Show InChI InChI=1S/C28H34FN3O5/c1-2-37-26-12-23(28(35)32-20-7-8-21(32)16-36-15-20)25(29)11-24(26)27(34)31-14-22(33)13-30-19-9-17-5-3-4-6-18(17)10-19/h3-6,11-12,19-22,30,33H,2,7-10,13-16H2,1H3,(H,31,34)/t20?,21?,22-/m0/s1
PDB

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CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401688
PNG
(US10005792, Compound 51)
Show SMILES COc1ccc(CN(CC(O)CNC(=O)c2ccnc(OC3CCNCC3)c2)C2Cc3ccccc3C2)c(OC)c1
Show InChI InChI=1S/C32H40N4O5/c1-39-29-8-7-25(30(18-29)40-2)20-36(26-15-22-5-3-4-6-23(22)16-26)21-27(37)19-35-32(38)24-9-14-34-31(17-24)41-28-10-12-33-13-11-28/h3-9,14,17-18,26-28,33,37H,10-13,15-16,19-21H2,1-2H3,(H,35,38)
PDB

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n/an/a 709n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401735
PNG
(US10005792, Compound 96)
Show SMILES CC(=O)N1CCc2ccc(cc2C1)C(=O)NCC(O)CNC1Cc2ccccc2C1
Show InChI InChI=1S/C24H29N3O3/c1-16(28)27-9-8-17-6-7-20(10-21(17)15-27)24(30)26-14-23(29)13-25-22-11-18-4-2-3-5-19(18)12-22/h2-7,10,22-23,25,29H,8-9,11-15H2,1H3,(H,26,30)
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n/an/a 733n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401781
PNG
(US10005792, Compound 139)
Show SMILES CC(=O)N1CC2CCC(C1)C2Nc1cccc(c1)C(=O)NC[C@@H](O)CNC1Cc2ccccc2C1
Show InChI InChI=1S/C28H36N4O3/c1-18(33)32-16-22-9-10-23(17-32)27(22)31-24-8-4-7-21(13-24)28(35)30-15-26(34)14-29-25-11-19-5-2-3-6-20(19)12-25/h2-8,13,22-23,25-27,29,31,34H,9-12,14-17H2,1H3,(H,30,35)/t22?,23?,26-,27?/m0/s1
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n/an/a 771n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401616
PNG
(US10005792, Compound 1)
Show SMILES OC(CNC1Cc2ccccc2C1)CNC(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C19H21ClN2O2/c20-16-7-5-13(6-8-16)19(24)22-12-18(23)11-21-17-9-14-3-1-2-4-15(14)10-17/h1-8,17-18,21,23H,9-12H2,(H,22,24)
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n/an/a 792n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401648
PNG
(US10005792, Compound 11)
Show SMILES O[C@H](CNC1Cc2ccccc2C1)CNC(=O)c1ccc(nc1)N1CCOCC1
Show InChI InChI=1S/C22H28N4O3/c27-20(14-23-19-11-16-3-1-2-4-17(16)12-19)15-25-22(28)18-5-6-21(24-13-18)26-7-9-29-10-8-26/h1-6,13,19-20,23,27H,7-12,14-15H2,(H,25,28)/t20-/m1/s1
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n/an/a 830n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401728
PNG
(US10005792, Compound 89)
Show SMILES COC(=O)Cc1ccc(cc1)C(=O)NC[C@@H](O)CNC1Cc2ccccc2C1
Show InChI InChI=1S/C22H26N2O4/c1-28-21(26)10-15-6-8-16(9-7-15)22(27)24-14-20(25)13-23-19-11-17-4-2-3-5-18(17)12-19/h2-9,19-20,23,25H,10-14H2,1H3,(H,24,27)/t20-/m0/s1
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n/an/a 853n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401695
PNG
(US10005792, Compound 58)
Show SMILES CC(=O)N1CC(C1)Nc1cc(ncn1)C(=O)NCC(O)CNC1Cc2ccccc2C1
Show InChI InChI=1S/C22H28N6O3/c1-14(29)28-11-18(12-28)27-21-8-20(25-13-26-21)22(31)24-10-19(30)9-23-17-6-15-4-2-3-5-16(15)7-17/h2-5,8,13,17-19,23,30H,6-7,9-12H2,1H3,(H,24,31)(H,25,26,27)
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n/an/a 883n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401667
PNG
(US10005792, Compound 30)
Show SMILES OC(CNC1CCc2ccccc2C1)CNC(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H23ClN2O2/c21-17-8-5-15(6-9-17)20(25)23-13-19(24)12-22-18-10-7-14-3-1-2-4-16(14)11-18/h1-6,8-9,18-19,22,24H,7,10-13H2,(H,23,25)
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n/an/a 905n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401734
PNG
(US10005792, Compound 95)
Show SMILES CC(=O)N1CCc2cc(ccc2C1)C(=O)NCC(O)CNC1Cc2ccccc2C1
Show InChI InChI=1S/C24H29N3O3/c1-16(28)27-9-8-19-10-20(6-7-21(19)15-27)24(30)26-14-23(29)13-25-22-11-17-4-2-3-5-18(17)12-22/h2-7,10,22-23,25,29H,8-9,11-15H2,1H3,(H,26,30)
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n/an/a 931n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401656
PNG
(US10005792, Compound 20)
Show SMILES OC(CNC1Cc2ccccc2C1)CNC(=O)c1ccc(cc1)C(=O)N1CCC1
Show InChI InChI=1S/C23H27N3O3/c27-21(14-24-20-12-18-4-1-2-5-19(18)13-20)15-25-22(28)16-6-8-17(9-7-16)23(29)26-10-3-11-26/h1-2,4-9,20-21,24,27H,3,10-15H2,(H,25,28)
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n/an/a 977n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401680
PNG
(US10005792, Compound 43)
Show SMILES CN(C1CCCC1)c1cc(ccn1)C(=O)NCC(O)CNC1Cc2ccccc2C1
Show InChI InChI=1S/C24H32N4O2/c1-28(21-8-4-5-9-21)23-14-19(10-11-25-23)24(30)27-16-22(29)15-26-20-12-17-6-2-3-7-18(17)13-20/h2-3,6-7,10-11,14,20-22,26,29H,4-5,8-9,12-13,15-16H2,1H3,(H,27,30)
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n/an/a 1.01E+3n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401738
PNG
(US10005792, Compound 100)
Show SMILES O[C@@H](CNC1Cc2ccccc2C1)CNC(=O)c1ccc(CC(=O)N2CCCC2)cc1
Show InChI InChI=1S/C25H31N3O3/c29-23(16-26-22-14-20-5-1-2-6-21(20)15-22)17-27-25(31)19-9-7-18(8-10-19)13-24(30)28-11-3-4-12-28/h1-2,5-10,22-23,26,29H,3-4,11-17H2,(H,27,31)/t23-/m0/s1
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n/an/a 1.10E+3n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401701
PNG
(US10005792, Compound 64)
Show SMILES CC(=O)N1CCC(CC1)Nc1ccc(cc1)C(=O)NCC(O)CNC1Cc2ccccc2C1
Show InChI InChI=1S/C26H34N4O3/c1-18(31)30-12-10-23(11-13-30)29-22-8-6-19(7-9-22)26(33)28-17-25(32)16-27-24-14-20-4-2-3-5-21(20)15-24/h2-9,23-25,27,29,32H,10-17H2,1H3,(H,28,33)
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n/an/a 1.10E+3n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401657
PNG
(US10005792, Compound 21)
Show SMILES OC(CNC1Cc2ccccc2C1)CNC(=O)c1ccc(cc1)C(=O)N1CCCC1
Show InChI InChI=1S/C24H29N3O3/c28-22(15-25-21-13-19-5-1-2-6-20(19)14-21)16-26-23(29)17-7-9-18(10-8-17)24(30)27-11-3-4-12-27/h1-2,5-10,21-22,25,28H,3-4,11-16H2,(H,26,29)
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n/an/a 1.11E+3n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401771
PNG
(US10005792, Compound 130)
Show SMILES CCOc1c(C)c(ccc1C(=O)NC[C@@H](O)CNC1Cc2ccccc2C1)C(=O)N1CCOCC1
Show InChI InChI=1S/C27H35N3O5/c1-3-35-25-18(2)23(27(33)30-10-12-34-13-11-30)8-9-24(25)26(32)29-17-22(31)16-28-21-14-19-6-4-5-7-20(19)15-21/h4-9,21-22,28,31H,3,10-17H2,1-2H3,(H,29,32)/t22-/m0/s1
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n/an/a 1.13E+3n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401730
PNG
(US10005792, Compound 91)
Show SMILES O[C@H](CNC1Cc2ccccc2C1)CNC(=O)c1ccc(CC(=O)N2CCCC2)cc1
Show InChI InChI=1S/C25H31N3O3/c29-23(16-26-22-14-20-5-1-2-6-21(20)15-22)17-27-25(31)19-9-7-18(8-10-19)13-24(30)28-11-3-4-12-28/h1-2,5-10,22-23,26,29H,3-4,11-17H2,(H,27,31)/t23-/m1/s1
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n/an/a 1.23E+3n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401702
PNG
(US10005792, Compound 65)
Show SMILES O[C@@H](CNC1Cc2ccccc2C1)CNC(=O)c1ccc(cc1)C(=O)C1CCS(=O)(=O)CC1
Show InChI InChI=1S/C25H30N2O5S/c28-23(15-26-22-13-20-3-1-2-4-21(20)14-22)16-27-25(30)19-7-5-17(6-8-19)24(29)18-9-11-33(31,32)12-10-18/h1-8,18,22-23,26,28H,9-16H2,(H,27,30)/t23-/m0/s1
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n/an/a 1.30E+3n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401733
PNG
(US10005792, Compound 94)
Show SMILES OC(CNC1Cc2ccccc2C1)CNC(=O)c1ccc2CN(CCc2c1)C(=O)CC1CC1
Show InChI InChI=1S/C27H33N3O3/c31-25(15-28-24-13-19-3-1-2-4-20(19)14-24)16-29-27(33)22-7-8-23-17-30(10-9-21(23)12-22)26(32)11-18-5-6-18/h1-4,7-8,12,18,24-25,28,31H,5-6,9-11,13-17H2,(H,29,33)
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n/an/a 1.35E+3n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401719
PNG
(US10005792, Compound 81)
Show SMILES COC1CCN(C1)C(=O)c1ccc(cc1)C(=O)NC[C@@H](O)CNC1Cc2ccccc2C1
Show InChI InChI=1S/C25H31N3O4/c1-32-23-10-11-28(16-23)25(31)18-8-6-17(7-9-18)24(30)27-15-22(29)14-26-21-12-19-4-2-3-5-20(19)13-21/h2-9,21-23,26,29H,10-16H2,1H3,(H,27,30)/t22-,23?/m0/s1
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n/an/a 1.37E+3n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401731
PNG
(US10005792, Compound 92)
Show SMILES OC(CNC1Cc2ccccc2C1)CNC(=O)c1ccc2CN(Cc2c1)C(=O)CC1CC1
Show InChI InChI=1S/C26H31N3O3/c30-24(13-27-23-11-18-3-1-2-4-19(18)12-23)14-28-26(32)20-7-8-21-15-29(16-22(21)10-20)25(31)9-17-5-6-17/h1-4,7-8,10,17,23-24,27,30H,5-6,9,11-16H2,(H,28,32)
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n/an/a 1.38E+3n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401647
PNG
(US10005792, Compound 10)
Show SMILES O[C@H](CNC1Cc2ccccc2C1)CNC(=O)c1cnn(c1)-c1cccc(Cl)c1
Show InChI InChI=1S/C22H23ClN4O2/c23-18-6-3-7-20(10-18)27-14-17(11-26-27)22(29)25-13-21(28)12-24-19-8-15-4-1-2-5-16(15)9-19/h1-7,10-11,14,19,21,24,28H,8-9,12-13H2,(H,25,29)/t21-/m1/s1
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n/an/a 1.44E+3n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401643
PNG
(US10005792, Compound 6)
Show SMILES COc1ccc(cc1)-c1cc(no1)C(=O)NC[C@H](O)CNC1Cc2ccccc2C1
Show InChI InChI=1S/C23H25N3O4/c1-29-20-8-6-15(7-9-20)22-12-21(26-30-22)23(28)25-14-19(27)13-24-18-10-16-4-2-3-5-17(16)11-18/h2-9,12,18-19,24,27H,10-11,13-14H2,1H3,(H,25,28)/t19-/m1/s1
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n/an/a 1.55E+3n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401704
PNG
(US10005792, Compound 66)
Show SMILES O[C@@H](CNC1Cc2ccccc2C1)CNC(=O)c1ccc(cc1)C(=O)N1CC2(COC2)C1
Show InChI InChI=1S/C25H29N3O4/c29-22(11-26-21-9-19-3-1-2-4-20(19)10-21)12-27-23(30)17-5-7-18(8-6-17)24(31)28-13-25(14-28)15-32-16-25/h1-8,21-22,26,29H,9-16H2,(H,27,30)/t22-/m0/s1
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n/an/a 1.56E+3n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401721
PNG
(US10005792, Compound 82)
Show SMILES OC(CNC1Cc2ccccc2C1)CNC(=O)c1ccn(Cc2ccccc2)c(=O)c1
Show InChI InChI=1S/C25H27N3O3/c29-23(15-26-22-12-19-8-4-5-9-20(19)13-22)16-27-25(31)21-10-11-28(24(30)14-21)17-18-6-2-1-3-7-18/h1-11,14,22-23,26,29H,12-13,15-17H2,(H,27,31)
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n/an/a 1.81E+3n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401661
PNG
(US10005792, Compound 25)
Show SMILES OC(CNC1Cc2ccccc2C1)CNC(=O)c1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C25H26N2O2/c28-24(16-26-23-14-20-9-4-5-10-21(20)15-23)17-27-25(29)22-12-6-11-19(13-22)18-7-2-1-3-8-18/h1-13,23-24,26,28H,14-17H2,(H,27,29)
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n/an/a 2.22E+3n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401644
PNG
(US10005792, Compound 7)
Show SMILES COc1ccc(cc1)-c1cc(on1)C(=O)NC[C@H](O)CNC1Cc2ccccc2C1
Show InChI InChI=1S/C23H25N3O4/c1-29-20-8-6-15(7-9-20)21-12-22(30-26-21)23(28)25-14-19(27)13-24-18-10-16-4-2-3-5-17(16)11-18/h2-9,12,18-19,24,27H,10-11,13-14H2,1H3,(H,25,28)/t19-/m1/s1
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n/an/a 2.45E+3n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401694
PNG
(US10005792, Compound 57)
Show SMILES CC(=O)N1CCC(CC1)Nc1cccc(n1)C(=O)NCC(O)CNC1Cc2ccccc2C1
Show InChI InChI=1S/C25H33N5O3/c1-17(31)30-11-9-20(10-12-30)28-24-8-4-7-23(29-24)25(33)27-16-22(32)15-26-21-13-18-5-2-3-6-19(18)14-21/h2-8,20-22,26,32H,9-16H2,1H3,(H,27,33)(H,28,29)
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n/an/a 2.53E+3n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401726
PNG
(US10005792, Compound 87)
Show SMILES COc1cc(CC(=O)N2CCOCC2)ccc1C(=O)NC[C@@H](O)CNC1Cc2ccccc2C1
Show InChI InChI=1S/C26H33N3O5/c1-33-24-12-18(13-25(31)29-8-10-34-11-9-29)6-7-23(24)26(32)28-17-22(30)16-27-21-14-19-4-2-3-5-20(19)15-21/h2-7,12,21-22,27,30H,8-11,13-17H2,1H3,(H,28,32)/t22-/m0/s1
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n/an/a 2.76E+3n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401712
PNG
(US10005792, Compound 74)
Show SMILES CC(C)Oc1ccccc1C(=O)NCC(O)CNC1Cc2ccccc2C1
Show InChI InChI=1S/C22H28N2O3/c1-15(2)27-21-10-6-5-9-20(21)22(26)24-14-19(25)13-23-18-11-16-7-3-4-8-17(16)12-18/h3-10,15,18-19,23,25H,11-14H2,1-2H3,(H,24,26)
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n/an/a 3.14E+3n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401729
PNG
(US10005792, Compound 90)
Show SMILES O[C@@H](CNC1Cc2ccccc2C1)CNC(=O)c1ccc(CC(=O)N2CCOCC2)cc1
Show InChI InChI=1S/C25H31N3O4/c29-23(16-26-22-14-20-3-1-2-4-21(20)15-22)17-27-25(31)19-7-5-18(6-8-19)13-24(30)28-9-11-32-12-10-28/h1-8,22-23,26,29H,9-17H2,(H,27,31)/t23-/m0/s1
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n/an/a 3.15E+3n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401722
PNG
(US10005792, Compound 83)
Show SMILES CC(=O)N1CCN(CC1)C(=O)Cc1ccc(cc1)C(=O)NCC(O)CNC1Cc2ccccc2C1
Show InChI InChI=1S/C27H34N4O4/c1-19(32)30-10-12-31(13-11-30)26(34)14-20-6-8-21(9-7-20)27(35)29-18-25(33)17-28-24-15-22-4-2-3-5-23(22)16-24/h2-9,24-25,28,33H,10-18H2,1H3,(H,29,35)
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n/an/a 3.46E+3n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401646
PNG
(US10005792, Compound 9)
Show SMILES O[C@H](CNC1Cc2ccccc2C1)CNC(=O)c1cnn(c1)-c1ccc(F)cc1
Show InChI InChI=1S/C22H23FN4O2/c23-18-5-7-20(8-6-18)27-14-17(11-26-27)22(29)25-13-21(28)12-24-19-9-15-3-1-2-4-16(15)10-19/h1-8,11,14,19,21,24,28H,9-10,12-13H2,(H,25,29)/t21-/m1/s1
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n/an/a 3.72E+3n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401619
PNG
(US10005792, Compound 4)
Show SMILES O[C@H](CNC1Cc2ccccc2C1)CNC(=O)c1cnn(c1)-c1ccccc1
Show InChI InChI=1S/C22H24N4O2/c27-21(13-23-19-10-16-6-4-5-7-17(16)11-19)14-24-22(28)18-12-25-26(15-18)20-8-2-1-3-9-20/h1-9,12,15,19,21,23,27H,10-11,13-14H2,(H,24,28)/t21-/m1/s1
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n/an/a 3.79E+3n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401663
PNG
(US10005792, Compound 26)
Show SMILES OC(CNC1Cc2ccccc2C1)CNC(=O)c1ccccc1-c1ccccc1
Show InChI InChI=1S/C25H26N2O2/c28-22(16-26-21-14-19-10-4-5-11-20(19)15-21)17-27-25(29)24-13-7-6-12-23(24)18-8-2-1-3-9-18/h1-13,21-22,26,28H,14-17H2,(H,27,29)
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n/an/a 3.87E+3n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401754
PNG
(US10005792, Compound 113)
Show SMILES O[C@@H](CNC1Cc2ccccc2C1)CNC(=O)c1cccc2ncsc12
Show InChI InChI=1S/C20H21N3O2S/c24-16(10-21-15-8-13-4-1-2-5-14(13)9-15)11-22-20(25)17-6-3-7-18-19(17)26-12-23-18/h1-7,12,15-16,21,24H,8-11H2,(H,22,25)/t16-/m0/s1
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n/an/a 4.15E+3n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401736
PNG
(US10005792, Compound 97)
Show SMILES OC(CNC1Cc2ccccc2C1)CNC(=O)c1ccccc1OCC(F)(F)F
Show InChI InChI=1S/C21H23F3N2O3/c22-21(23,24)13-29-19-8-4-3-7-18(19)20(28)26-12-17(27)11-25-16-9-14-5-1-2-6-15(14)10-16/h1-8,16-17,25,27H,9-13H2,(H,26,28)
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n/an/a 4.32E+3n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401711
PNG
(US10005792, Compound 73)
Show SMILES CCCOc1ccccc1C(=O)NCC(O)CNC1Cc2ccccc2C1
Show InChI InChI=1S/C22H28N2O3/c1-2-11-27-21-10-6-5-9-20(21)22(26)24-15-19(25)14-23-18-12-16-7-3-4-8-17(16)13-18/h3-10,18-19,23,25H,2,11-15H2,1H3,(H,24,26)
PDB

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n/an/a 4.38E+3n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401666
PNG
(US10005792, Compound 29)
Show SMILES OC(CCNC(=O)c1ccc(Cl)cc1)CNC1Cc2ccccc2C1
Show InChI InChI=1S/C20H23ClN2O2/c21-17-7-5-14(6-8-17)20(25)22-10-9-19(24)13-23-18-11-15-3-1-2-4-16(15)12-18/h1-8,18-19,23-24H,9-13H2,(H,22,25)
PDB

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n/an/a 4.43E+3n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401772
PNG
(US10005792, Compound 131)
Show SMILES O[C@@H](CNC1Cc2ccccc2C1)CNC(=O)c1ccccc1Cl
Show InChI InChI=1S/C19H21ClN2O2/c20-18-8-4-3-7-17(18)19(24)22-12-16(23)11-21-15-9-13-5-1-2-6-14(13)10-15/h1-8,15-16,21,23H,9-12H2,(H,22,24)/t16-/m0/s1
PDB

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n/an/a 4.59E+3n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401782
PNG
(US10005792, Compound 140)
Show SMILES CS(=O)(=O)Nc1cccc(c1)C(=O)NC[C@@H](O)CNC1Cc2ccccc2C1
Show InChI InChI=1S/C20H25N3O4S/c1-28(26,27)23-17-8-4-7-16(11-17)20(25)22-13-19(24)12-21-18-9-14-5-2-3-6-15(14)10-18/h2-8,11,18-19,21,23-24H,9-10,12-13H2,1H3,(H,22,25)/t19-/m0/s1
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n/an/a 4.68E+3n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401685
PNG
(US10005792, Compound 48)
Show SMILES OC(CNC1Cc2ccccc2C1)CNC(=O)c1ccnc(c1)N1CCCC1
Show InChI InChI=1S/C22H28N4O2/c27-20(14-24-19-11-16-5-1-2-6-17(16)12-19)15-25-22(28)18-7-8-23-21(13-18)26-9-3-4-10-26/h1-2,5-8,13,19-20,24,27H,3-4,9-12,14-15H2,(H,25,28)
PDB

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n/an/a 4.78E+3n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401683
PNG
(US10005792, Compound 46)
Show SMILES OC(CNC1Cc2ccccc2C1)CNC(=O)c1cnn(c1)-c1cccnc1
Show InChI InChI=1S/C21H23N5O2/c27-20(12-23-18-8-15-4-1-2-5-16(15)9-18)13-24-21(28)17-10-25-26(14-17)19-6-3-7-22-11-19/h1-7,10-11,14,18,20,23,27H,8-9,12-13H2,(H,24,28)
PDB

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n/an/a 4.99E+3n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401760
PNG
(US10005792, Compound 119)
Show SMILES O[C@@H](CNC1Cc2ccccc2C1)CNC(=O)c1cccc(OC(F)F)c1
Show InChI InChI=1S/C20H22F2N2O3/c21-20(22)27-18-7-3-6-15(10-18)19(26)24-12-17(25)11-23-16-8-13-4-1-2-5-14(13)9-16/h1-7,10,16-17,20,23,25H,8-9,11-12H2,(H,24,26)/t17-/m0/s1
PDB

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n/an/a 5.08E+3n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401716
PNG
(US10005792, Compound 78)
Show SMILES O[C@@H](CNC1Cc2ccccc2C1)CNC(=O)c1ccc(CC(=O)N2CCCCC2)nc1
Show InChI InChI=1S/C25H32N4O3/c30-23(16-27-22-12-18-6-2-3-7-19(18)13-22)17-28-25(32)20-8-9-21(26-15-20)14-24(31)29-10-4-1-5-11-29/h2-3,6-9,15,22-23,27,30H,1,4-5,10-14,16-17H2,(H,28,32)/t23-/m0/s1
PDB

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n/an/a 5.58E+3n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401691
PNG
(US10005792, Compound 54)
Show SMILES CC(=O)N1CCC(CC1)Oc1nccc(n1)C(=O)NCC(O)CNC1Cc2ccccc2C1
Show InChI InChI=1S/C24H31N5O4/c1-16(30)29-10-7-21(8-11-29)33-24-25-9-6-22(28-24)23(32)27-15-20(31)14-26-19-12-17-4-2-3-5-18(17)13-19/h2-6,9,19-21,26,31H,7-8,10-15H2,1H3,(H,27,32)
PDB

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n/an/a 5.77E+3n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401706
PNG
(US10005792, Compound 68)
Show SMILES O[C@@H](CNC1Cc2ccccc2C1)CNC(=O)c1ccc(nc1)C(=O)N1CCCCC1
Show InChI InChI=1S/C24H30N4O3/c29-21(15-25-20-12-17-6-2-3-7-18(17)13-20)16-27-23(30)19-8-9-22(26-14-19)24(31)28-10-4-1-5-11-28/h2-3,6-9,14,20-21,25,29H,1,4-5,10-13,15-16H2,(H,27,30)/t21-/m0/s1
PDB

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n/an/a 6.17E+3n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401766
PNG
(US10005792, Compound 125)
Show SMILES O[C@@H](CNC1Cc2ccccc2C1)CNC(=O)c1cccc2scnc12
Show InChI InChI=1S/C20H21N3O2S/c24-16(10-21-15-8-13-4-1-2-5-14(13)9-15)11-22-20(25)17-6-3-7-18-19(17)23-12-26-18/h1-7,12,15-16,21,24H,8-11H2,(H,22,25)/t16-/m0/s1
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n/an/a 6.72E+3n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401705
PNG
(US10005792, Compound 67)
Show SMILES OC(CNC1Cc2ccccc2C1)CNC(=O)c1ccc(nc1)C(=O)N1CCCCC1
Show InChI InChI=1S/C24H30N4O3/c29-21(15-25-20-12-17-6-2-3-7-18(17)13-20)16-27-23(30)19-8-9-22(26-14-19)24(31)28-10-4-1-5-11-28/h2-3,6-9,14,20-21,25,29H,1,4-5,10-13,15-16H2,(H,27,30)
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n/an/a 6.87E+3n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401699
PNG
(US10005792, Compound 62)
Show SMILES O[C@@H](CNC1Cc2ccccc2C1)CNC(=O)c1cccc(c1)C(=O)N1CCOCC1
Show InChI InChI=1S/C24H29N3O4/c28-22(15-25-21-13-17-4-1-2-5-18(17)14-21)16-26-23(29)19-6-3-7-20(12-19)24(30)27-8-10-31-11-9-27/h1-7,12,21-22,25,28H,8-11,13-16H2,(H,26,29)/t22-/m0/s1
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n/an/a 6.93E+3n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401700
PNG
(US10005792, Compound 63)
Show SMILES OC(CNC1Cc2ccccc2C1)CNC(=O)c1ccc(cc1)N1CCCCC1=O
Show InChI InChI=1S/C24H29N3O3/c28-22(15-25-20-13-18-5-1-2-6-19(18)14-20)16-26-24(30)17-8-10-21(11-9-17)27-12-4-3-7-23(27)29/h1-2,5-6,8-11,20,22,25,28H,3-4,7,12-16H2,(H,26,30)
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n/an/a 7.30E+3n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401724
PNG
(US10005792, Compound 85)
Show SMILES Cn1ccc(cc1=O)C(=O)NCC(O)CNC1Cc2ccccc2C1
Show InChI InChI=1S/C19H23N3O3/c1-22-7-6-15(10-18(22)24)19(25)21-12-17(23)11-20-16-8-13-4-2-3-5-14(13)9-16/h2-7,10,16-17,20,23H,8-9,11-12H2,1H3,(H,21,25)
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n/an/a 7.68E+3n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401753
PNG
(US10005792, Compound 112)
Show SMILES CN(C[C@H](O)CNC(=O)c1ccc(cc1)C(=O)N1CCOCC1)C1Cc2ccccc2C1
Show InChI InChI=1S/C25H31N3O4/c1-27(22-14-20-4-2-3-5-21(20)15-22)17-23(29)16-26-24(30)18-6-8-19(9-7-18)25(31)28-10-12-32-13-11-28/h2-9,22-23,29H,10-17H2,1H3,(H,26,30)/t23-/m1/s1
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n/an/a 9.41E+3n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401642
PNG
(US10005792, Compound 5)
Show SMILES Cc1nn(C)cc1-c1cc(no1)C(=O)NC[C@H](O)CNC1Cc2ccccc2C1
Show InChI InChI=1S/C21H25N5O3/c1-13-18(12-26(2)24-13)20-9-19(25-29-20)21(28)23-11-17(27)10-22-16-7-14-5-3-4-6-15(14)8-16/h3-6,9,12,16-17,22,27H,7-8,10-11H2,1-2H3,(H,23,28)/t17-/m1/s1
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n/an/a 9.78E+3n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401707
PNG
(US10005792, Compound 69)
Show SMILES O[C@H](CNC1Cc2ccccc2C1)CNC(=O)c1ccc(nc1)C(=O)N1CCCCC1
Show InChI InChI=1S/C24H30N4O3/c29-21(15-25-20-12-17-6-2-3-7-18(17)13-20)16-27-23(30)19-8-9-22(26-14-19)24(31)28-10-4-1-5-11-28/h2-3,6-9,14,20-21,25,29H,1,4-5,10-13,15-16H2,(H,27,30)/t21-/m1/s1
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n/an/a 1.00E+4n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401752
PNG
(US10005792, Compound 111)
Show SMILES CN(C[C@@H](O)CNC1Cc2ccccc2C1)C(=O)c1ccc(cc1)C(=O)N1CCOCC1
Show InChI InChI=1S/C25H31N3O4/c1-27(17-23(29)16-26-22-14-20-4-2-3-5-21(20)15-22)24(30)18-6-8-19(9-7-18)25(31)28-10-12-32-13-11-28/h2-9,22-23,26,29H,10-17H2,1H3/t23-/m0/s1
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n/an/a 1.04E+4n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401750
PNG
(US10005792, Compound 109)
Show SMILES CS(=O)(=O)N1CC(C1)Nc1cc(ccn1)C(=O)NC[C@@H](O)CNC1Cc2ccccc2C1
Show InChI InChI=1S/C22H29N5O4S/c1-32(30,31)27-13-19(14-27)26-21-10-17(6-7-23-21)22(29)25-12-20(28)11-24-18-8-15-4-2-3-5-16(15)9-18/h2-7,10,18-20,24,28H,8-9,11-14H2,1H3,(H,23,26)(H,25,29)/t20-/m0/s1
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n/an/a 1.11E+4n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401684
PNG
(US10005792, Compound 47)
Show SMILES OC(CNC1Cc2ccccc2C1)CNC(=O)c1ccnc(c1)N1CCOCC1
Show InChI InChI=1S/C22H28N4O3/c27-20(14-24-19-11-16-3-1-2-4-17(16)12-19)15-25-22(28)18-5-6-23-21(13-18)26-7-9-29-10-8-26/h1-6,13,19-20,24,27H,7-12,14-15H2,(H,25,28)
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n/an/a 1.14E+4n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401682
PNG
(US10005792, Compound 45)
Show SMILES OC(CNC1Cc2ccccc2C1)CNC(=O)c1cc([nH]n1)-c1ccccn1
Show InChI InChI=1/C21H23N5O2/c27-17(12-23-16-9-14-5-1-2-6-15(14)10-16)13-24-21(28)20-11-19(25-26-20)18-7-3-4-8-22-18/h1-8,11,16-17,23,27H,9-10,12-13H2,(H,24,28)(H,25,26)
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n/an/a 1.28E+4n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401761
PNG
(US10005792, Compound 120)
Show SMILES O[C@@H](CNC1Cc2ccccc2C1)CNC(=O)c1cccc2[nH]cnc12
Show InChI InChI=1/C20H22N4O2/c25-16(10-21-15-8-13-4-1-2-5-14(13)9-15)11-22-20(26)17-6-3-7-18-19(17)24-12-23-18/h1-7,12,15-16,21,25H,8-11H2,(H,22,26)(H,23,24)/t16-/s2
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n/an/a 1.33E+4n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401769
PNG
(US10005792, Compound 128)
Show SMILES O[C@@H](CNC1Cc2ccccc2C1)CNC(=O)c1cccc2[nH]ncc12
Show InChI InChI=1/C20H22N4O2/c25-16(10-21-15-8-13-4-1-2-5-14(13)9-15)11-22-20(26)17-6-3-7-19-18(17)12-23-24-19/h1-7,12,15-16,21,25H,8-11H2,(H,22,26)(H,23,24)/t16-/s2
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n/an/a 1.54E+4n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401780
PNG
(US10005792, Compound 138)
Show SMILES O[C@@H](CNC1Cc2ccccc2C1)CNC(=O)c1cccc(c1)C(F)F
Show InChI InChI=1S/C20H22F2N2O2/c21-19(22)15-6-3-7-16(8-15)20(26)24-12-18(25)11-23-17-9-13-4-1-2-5-14(13)10-17/h1-8,17-19,23,25H,9-12H2,(H,24,26)/t18-/m0/s1
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n/an/a 1.69E+4n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401669
PNG
(US10005792, Compound 32)
Show SMILES OC(CNC1CCc2cc(F)ccc2C1)CNC(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H22ClFN2O2/c21-16-5-1-13(2-6-16)20(26)24-12-19(25)11-23-18-8-4-14-9-17(22)7-3-15(14)10-18/h1-3,5-7,9,18-19,23,25H,4,8,10-12H2,(H,24,26)
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n/an/a 1.88E+4n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401746
PNG
(US10005792, Compound 108)
Show SMILES OCC(CNC1Cc2ccccc2C1)CNC(=O)c1ccc(cc1)C(=O)N1CCOCC1
Show InChI InChI=1S/C25H31N3O4/c29-17-18(15-26-23-13-21-3-1-2-4-22(21)14-23)16-27-24(30)19-5-7-20(8-6-19)25(31)28-9-11-32-12-10-28/h1-8,18,23,26,29H,9-17H2,(H,27,30)
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n/an/a 2.12E+4n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401668
PNG
(US10005792, Compound 31)
Show SMILES OC(CNC1CCc2ccc(F)cc2C1)CNC(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H22ClFN2O2/c21-16-5-1-14(2-6-16)20(26)24-12-19(25)11-23-18-8-4-13-3-7-17(22)9-15(13)10-18/h1-3,5-7,9,18-19,23,25H,4,8,10-12H2,(H,24,26)
PDB

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n/an/a 2.26E+4n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401717
PNG
(US10005792, Compound 79)
Show SMILES COCc1ccccc1C(=O)NCC(O)CNC1Cc2ccccc2C1
Show InChI InChI=1S/C21H26N2O3/c1-26-14-17-8-4-5-9-20(17)21(25)23-13-19(24)12-22-18-10-15-6-2-3-7-16(15)11-18/h2-9,18-19,22,24H,10-14H2,1H3,(H,23,25)
PDB

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n/an/a 2.40E+4n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401744
PNG
(US10005792, Compound 106)
Show SMILES COc1ccc(CN(CC(CNC(=O)c2ccc(cc2)C(=O)N2C3CCC2COC3)N=[N+]=[N-])C2Cc3ccccc3C2)c(OC)c1
Show InChI InChI=1S/C35H40N6O5/c1-44-32-14-11-27(33(17-32)45-2)19-40(31-15-25-5-3-4-6-26(25)16-31)20-28(38-39-36)18-37-34(42)23-7-9-24(10-8-23)35(43)41-29-12-13-30(41)22-46-21-29/h3-11,14,17,28-31H,12-13,15-16,18-22H2,1-2H3,(H,37,42)
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n/an/a 2.43E+4n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401670
PNG
(US10005792, Compound 33)
Show SMILES CN(CC(O)CNC(=O)c1ccc(Cl)cc1)C1CCc2ccccc2C1
Show InChI InChI=1S/C21H25ClN2O2/c1-24(19-11-8-15-4-2-3-5-17(15)12-19)14-20(25)13-23-21(26)16-6-9-18(22)10-7-16/h2-7,9-10,19-20,25H,8,11-14H2,1H3,(H,23,26)
PDB

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n/an/a 2.49E+4n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401686
PNG
(US10005792, Compound 49)
Show SMILES OC(CNC1Cc2ccccc2C1)CNC(=O)c1ccnc(c1)-n1cccn1
Show InChI InChI=1S/C21H23N5O2/c27-19(13-23-18-10-15-4-1-2-5-16(15)11-18)14-24-21(28)17-6-8-22-20(12-17)26-9-3-7-25-26/h1-9,12,18-19,23,27H,10-11,13-14H2,(H,24,28)
PDB

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n/an/a 2.53E+4n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401773
PNG
(US10005792, Compound 132)
Show SMILES O[C@@H](CNC1Cc2ccccc2C1)CNC(=O)c1cccc2cn[nH]c12
Show InChI InChI=1/C20H22N4O2/c25-17(11-21-16-8-13-4-1-2-5-14(13)9-16)12-22-20(26)18-7-3-6-15-10-23-24-19(15)18/h1-7,10,16-17,21,25H,8-9,11-12H2,(H,22,26)(H,23,24)/t17-/s2
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n/an/a 2.97E+4n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401758
PNG
(US10005792, Compound 117)
Show SMILES CNC(=O)c1cccc(c1)C(=O)NC[C@@H](O)CNC1Cc2ccccc2C1
Show InChI InChI=1S/C21H25N3O3/c1-22-20(26)16-7-4-8-17(9-16)21(27)24-13-19(25)12-23-18-10-14-5-2-3-6-15(14)11-18/h2-9,18-19,23,25H,10-13H2,1H3,(H,22,26)(H,24,27)/t19-/m0/s1
PDB

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UniChem
US Patent
n/an/a 3.14E+4n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401671
PNG
(US10005792, Compound 34)
Show SMILES OC(CNC1Cc2ccccc12)CNC(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C18H19ClN2O2/c19-14-7-5-12(6-8-14)18(23)21-11-15(22)10-20-17-9-13-3-1-2-4-16(13)17/h1-8,15,17,20,22H,9-11H2,(H,21,23)
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US Patent
n/an/a 4.11E+4n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401779
PNG
(US10005792, Compound 137)
Show SMILES O[C@@H](CNC1Cc2ccccc2C1)CNC(=O)c1ccccc1C(F)F
Show InChI InChI=1S/C20H22F2N2O2/c21-19(22)17-7-3-4-8-18(17)20(26)24-12-16(25)11-23-15-9-13-5-1-2-6-14(13)10-15/h1-8,15-16,19,23,25H,9-12H2,(H,24,26)/t16-/m0/s1
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US Patent
n/an/a 4.70E+4n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401745
PNG
(US10005792, Compound 107)
Show SMILES NC(=O)C(CNC1Cc2ccccc2C1)CNC(=O)c1ccc(cc1)C(=O)N1CCOCC1
Show InChI InChI=1S/C25H30N4O4/c26-23(30)21(15-27-22-13-19-3-1-2-4-20(19)14-22)16-28-24(31)17-5-7-18(8-6-17)25(32)29-9-11-33-12-10-29/h1-8,21-22,27H,9-16H2,(H2,26,30)(H,28,31)
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UniChem
US Patent
n/an/a 5.22E+4n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401665
PNG
(US10005792, Compound 28)
Show SMILES OC(CNC1Cc2ccc(Br)cc2C1)CNC(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C19H20BrClN2O2/c20-15-4-1-13-8-17(9-14(13)7-15)22-10-18(24)11-23-19(25)12-2-5-16(21)6-3-12/h1-7,17-18,22,24H,8-11H2,(H,23,25)
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US Patent
n/an/a 6.94E+4n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401689
PNG
(US10005792, Compound 52)
Show SMILES CC(=O)N1CCC(CC1)Oc1cncc(n1)C(=O)NCC(O)CNC1Cc2ccccc2C1
Show InChI InChI=1S/C24H31N5O4/c1-16(30)29-8-6-21(7-9-29)33-23-15-25-14-22(28-23)24(32)27-13-20(31)12-26-19-10-17-4-2-3-5-18(17)11-19/h2-5,14-15,19-21,26,31H,6-13H2,1H3,(H,27,32)
PDB

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UniChem
US Patent
n/an/a 7.46E+4n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5 (PRMT5)


(Homo sapiens (Human))
BDBM401759
PNG
(US10005792, Compound 118)
Show SMILES O[C@@H](CNC1Cc2ccccc2C1)CNC(=O)c1ccccc1C(F)(F)F
Show InChI InChI=1S/C20H21F3N2O2/c21-20(22,23)18-8-4-3-7-17(18)19(27)25-12-16(26)11-24-15-9-13-5-1-2-6-14(13)10-15/h1-8,15-16,24,26H,9-12H2,(H,25,27)/t16-/m0/s1
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UniChem
US Patent
n/an/a 1.03E+5n/an/an/an/an/an/a



CTXT PTY. LTD.

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A histone H4 derived peptide is used as substrate (amino acid ...


US Patent US10005792 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%