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Patent code US10010547

Compile Data Set for Download or QSAR
Found 147 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401997
PNG
(5-[[5-[2-methoxy-4-(oxazol-4-ylmethoxy)phenyl]-1H-...)
Show SMILES COc1cc(OCc2cocn2)ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1
Show InChI InChI=1S/C19H15N7O3/c1-27-17-4-14(29-10-13-9-28-11-23-13)2-3-15(17)16-5-18(26-25-16)24-19-8-21-12(6-20)7-22-19/h2-5,7-9,11H,10H2,1H3,(H2,22,24,25,26)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM402004
PNG
(5-[[5-[4-[(1-isopropyl-4-piperidyl)amino]-2-methox...)
Show SMILES COc1cc(NC2CCN(CC2)C(C)C)ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1
Show InChI InChI=1S/C23H28N8O/c1-15(2)31-8-6-16(7-9-31)27-17-4-5-19(21(10-17)32-3)20-11-22(30-29-20)28-23-14-25-18(12-24)13-26-23/h4-5,10-11,13-16,27H,6-9H2,1-3H3,(H2,26,28,29,30)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM402003
PNG
(5-[[5-[4-[(1-ethyl-4-piperidyl)amino]-2-methoxy-ph...)
Show SMILES CCN1CCC(CC1)Nc1ccc(-c2cc(Nc3cnc(cn3)C#N)n[nH]2)c(OC)c1
Show InChI InChI=1S/C22H26N8O/c1-3-30-8-6-15(7-9-30)26-16-4-5-18(20(10-16)31-2)19-11-21(29-28-19)27-22-14-24-17(12-23)13-25-22/h4-5,10-11,13-15,26H,3,6-9H2,1-2H3,(H2,25,27,28,29)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM402002
PNG
(5-[[5-[2-methoxy-4-[(1-methyl-4-piperidyl)amino]ph...)
Show SMILES COc1cc(NC2CCN(C)CC2)ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1
Show InChI InChI=1S/C21H24N8O/c1-29-7-5-14(6-8-29)25-15-3-4-17(19(9-15)30-2)18-10-20(28-27-18)26-21-13-23-16(11-22)12-24-21/h3-4,9-10,12-14,25H,5-8H2,1-2H3,(H2,24,26,27,28)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM402035
PNG
(5-[[5-[4-[(1-ethyl-4-piperidyl)methyl-methyl-amino...)
Show SMILES CCN1CCC(CN(C)c2ccc(-c3cc(Nc4cnc(cn4)C#N)n[nH]3)c(OC)c2)CC1
Show InChI InChI=1S/C24H30N8O/c1-4-32-9-7-17(8-10-32)16-31(2)19-5-6-20(22(11-19)33-3)21-12-23(30-29-21)28-24-15-26-18(13-25)14-27-24/h5-6,11-12,14-15,17H,4,7-10,16H2,1-3H3,(H2,27,28,29,30)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM402036
PNG
(5-[[5-[4-[(isobutylamino)methyl]-2-methoxy-phenyl]...)
Show SMILES COc1cc(CNCC(C)C)ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1
Show InChI InChI=1S/C20H23N7O/c1-13(2)9-22-10-14-4-5-16(18(6-14)28-3)17-7-19(27-26-17)25-20-12-23-15(8-21)11-24-20/h4-7,11-13,22H,9-10H2,1-3H3,(H2,24,25,26,27)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401974
PNG
(5-[[5-[2-methoxy-4-[(3R)-3-methylpiperazin-1-yl]ph...)
Show SMILES COc1cc(ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1)N1CCN[C@H](C)C1
Show InChI InChI=1S/C20H22N8O/c1-13-12-28(6-5-22-13)15-3-4-16(18(7-15)29-2)17-8-19(27-26-17)25-20-11-23-14(9-21)10-24-20/h3-4,7-8,10-11,13,22H,5-6,12H2,1-2H3,(H2,24,25,26,27)/t13-/m1/s1
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401985
PNG
(5-[[5-[4-[(3R)-4-ethyl-3-methyl-piperazin-1-yl]-2-...)
Show SMILES CCN1CCN(C[C@H]1C)c1ccc(-c2cc(Nc3cnc(cn3)C#N)n[nH]2)c(OC)c1
Show InChI InChI=1S/C22H26N8O/c1-4-29-7-8-30(14-15(29)2)17-5-6-18(20(9-17)31-3)19-10-21(28-27-19)26-22-13-24-16(11-23)12-25-22/h5-6,9-10,12-13,15H,4,7-8,14H2,1-3H3,(H2,25,26,27,28)/t15-/m1/s1
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401984
PNG
(5-[[5-[4-[(3R)-3,4-dimethylpiperazin-1-yl]-2-metho...)
Show SMILES COc1cc(ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1)N1CCN(C)[C@H](C)C1
Show InChI InChI=1S/C21H24N8O/c1-14-13-29(7-6-28(14)2)16-4-5-17(19(8-16)30-3)18-9-20(27-26-18)25-21-12-23-15(10-22)11-24-21/h4-5,8-9,11-12,14H,6-7,13H2,1-3H3,(H2,24,25,26,27)/t14-/m1/s1
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM402031
PNG
(5-[[5-[4-[[(3R)-1-isopropylpyrrolidin-3-yl]oxymeth...)
Show SMILES COc1cc(CO[C@@H]2CCN(C2)C(C)C)ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1
Show InChI InChI=1S/C23H27N7O2/c1-15(2)30-7-6-18(13-30)32-14-16-4-5-19(21(8-16)31-3)20-9-22(29-28-20)27-23-12-25-17(10-24)11-26-23/h4-5,8-9,11-12,15,18H,6-7,13-14H2,1-3H3,(H2,26,27,28,29)/t18-/m1/s1
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM402033
PNG
(5-[[5-[4-[(1-ethyl-4-piperidyl)methyl]-2-methoxy-p...)
Show SMILES CCN1CCC(Cc2ccc(-c3cc(Nc4cnc(cn4)C#N)n[nH]3)c(OC)c2)CC1
Show InChI InChI=1S/C23H27N7O/c1-3-30-8-6-16(7-9-30)10-17-4-5-19(21(11-17)31-2)20-12-22(29-28-20)27-23-15-25-18(13-24)14-26-23/h4-5,11-12,14-16H,3,6-10H2,1-2H3,(H2,26,27,28,29)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM402030
PNG
(5-[[5-[4-[[(3R)-1-ethylpyrrolidin-3-yl]oxymethyl]-...)
Show SMILES CCN1CC[C@H](C1)OCc1ccc(-c2cc(Nc3cnc(cn3)C#N)n[nH]2)c(OC)c1
Show InChI InChI=1S/C22H25N7O2/c1-3-29-7-6-17(13-29)31-14-15-4-5-18(20(8-15)30-2)19-9-21(28-27-19)26-22-12-24-16(10-23)11-25-22/h4-5,8-9,11-12,17H,3,6-7,13-14H2,1-2H3,(H2,25,26,27,28)/t17-/m1/s1
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401957
PNG
(5-[[5-[2-methoxy-4-(1-methylazetidin-3-yl)phenyl]-...)
Show SMILES COc1cc(ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1)C1CN(C)C1
Show InChI InChI=1S/C19H19N7O/c1-26-10-13(11-26)12-3-4-15(17(5-12)27-2)16-6-18(25-24-16)23-19-9-21-14(7-20)8-22-19/h3-6,8-9,13H,10-11H2,1-2H3,(H2,22,23,24,25)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM402010
PNG
(5-[[5-[2-methoxy-4-[(2R)-4-ethylmorpholin-2-yl]phe...)
Show SMILES CCN1CCO[C@@H](C1)c1ccc(-c2cc(Nc3cnc(cn3)C#N)n[nH]2)c(OC)c1
Show InChI InChI=1S/C21H23N7O2/c1-3-28-6-7-30-19(13-28)14-4-5-16(18(8-14)29-2)17-9-20(27-26-17)25-21-12-23-15(10-22)11-24-21/h4-5,8-9,11-12,19H,3,6-7,13H2,1-2H3,(H2,24,25,26,27)/t19-/m0/s1
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM402018
PNG
(5-[[5-[4-[[(2S)-1-ethylpyrrolidin-2-yl]methoxy]-2-...)
Show SMILES CCN1CCC[C@H]1COc1ccc(-c2cc(Nc3cnc(cn3)C#N)n[nH]2)c(OC)c1
Show InChI InChI=1S/C22H25N7O2/c1-3-29-8-4-5-16(29)14-31-17-6-7-18(20(9-17)30-2)19-10-21(28-27-19)26-22-13-24-15(11-23)12-25-22/h6-7,9-10,12-13,16H,3-5,8,14H2,1-2H3,(H2,25,26,27,28)/t16-/m0/s1
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM402020
PNG
(5-[[5-[4-[(cyclopropylmethylamino)methyl]-2-methox...)
Show SMILES COc1cc(CNCC2CC2)ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1
Show InChI InChI=1S/C20H21N7O/c1-28-18-6-14(10-22-9-13-2-3-13)4-5-16(18)17-7-19(27-26-17)25-20-12-23-15(8-21)11-24-20/h4-7,11-13,22H,2-3,9-10H2,1H3,(H2,24,25,26,27)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM402034
PNG
(5-[[5-[4-[(1-isopropyl-4-piperidyl)methyl]-2-metho...)
Show SMILES COc1cc(CC2CCN(CC2)C(C)C)ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1
Show InChI InChI=1S/C24H29N7O/c1-16(2)31-8-6-17(7-9-31)10-18-4-5-20(22(11-18)32-3)21-12-23(30-29-21)28-24-15-26-19(13-25)14-27-24/h4-5,11-12,14-17H,6-10H2,1-3H3,(H2,27,28,29,30)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401914
PNG
(5-[[5-[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]...)
Show SMILES COc1cc(ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1)N1CCN(C)CC1
Show InChI InChI=1S/C20H22N8O/c1-27-5-7-28(8-6-27)15-3-4-16(18(9-15)29-2)17-10-19(26-25-17)24-20-13-22-14(11-21)12-23-20/h3-4,9-10,12-13H,5-8H2,1-2H3,(H2,23,24,25,26)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401906
PNG
(5-[[5-[2-methoxy-4-[(tetrahydropyran-4-ylamino)met...)
Show SMILES COc1cc(CNC2CCOCC2)ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1
Show InChI InChI=1S/C21H23N7O2/c1-29-19-8-14(11-23-15-4-6-30-7-5-15)2-3-17(19)18-9-20(28-27-18)26-21-13-24-16(10-22)12-25-21/h2-3,8-9,12-13,15,23H,4-7,11H2,1H3,(H2,25,26,27,28)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM402029
PNG
(5-[[5-[4-[[(3S)-1-isopropylpyrrolidin-3-yl]oxymeth...)
Show SMILES COc1cc(CO[C@H]2CCN(C2)C(C)C)ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1
Show InChI InChI=1S/C23H27N7O2/c1-15(2)30-7-6-18(13-30)32-14-16-4-5-19(21(8-16)31-3)20-9-22(29-28-20)27-23-12-25-17(10-24)11-26-23/h4-5,8-9,11-12,15,18H,6-7,13-14H2,1-3H3,(H2,26,27,28,29)/t18-/m0/s1
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM402009
PNG
(5-[[5-[2-methoxy-4-[(2R)-4-methylmorpholin-2-yl]ph...)
Show SMILES COc1cc(ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1)[C@@H]1CN(C)CCO1
Show InChI InChI=1S/C20H21N7O2/c1-27-5-6-29-18(12-27)13-3-4-15(17(7-13)28-2)16-8-19(26-25-16)24-20-11-22-14(9-21)10-23-20/h3-4,7-8,10-11,18H,5-6,12H2,1-2H3,(H2,23,24,25,26)/t18-/m0/s1
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM402038
PNG
(5-[[5-[4-[(1-isopropyl-4-piperidyl)methyl-methyl-a...)
Show SMILES COc1cc(ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1)N(C)CC1CCN(CC1)C(C)C
Show InChI InChI=1S/C25H32N8O/c1-17(2)33-9-7-18(8-10-33)16-32(3)20-5-6-21(23(11-20)34-4)22-12-24(31-30-22)29-25-15-27-19(13-26)14-28-25/h5-6,11-12,14-15,17-18H,7-10,16H2,1-4H3,(H2,28,29,30,31)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401904
PNG
(5-[5-(4-{[(1-cyclopropane-carbonyl-piperidin-4-ylm...)
Show SMILES COc1cc(CNCC2CCN(CC2)C(=O)C2CC2)ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1
Show InChI InChI=1S/C26H30N8O2/c1-36-23-10-18(14-28-13-17-6-8-34(9-7-17)26(35)19-3-4-19)2-5-21(23)22-11-24(33-32-22)31-25-16-29-20(12-27)15-30-25/h2,5,10-11,15-17,19,28H,3-4,6-9,13-14H2,1H3,(H2,30,31,32,33)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM402028
PNG
(5-[[5-[4-[[(3S)-1-ethylpyrrolidin-3-yl]oxymethyl]-...)
Show SMILES CCN1CC[C@@H](C1)OCc1ccc(-c2cc(Nc3cnc(cn3)C#N)n[nH]2)c(OC)c1
Show InChI InChI=1S/C22H25N7O2/c1-3-29-7-6-17(13-29)31-14-15-4-5-18(20(8-15)30-2)19-9-21(28-27-19)26-22-12-24-16(10-23)11-25-22/h4-5,8-9,11-12,17H,3,6-7,13-14H2,1-2H3,(H2,25,26,27,28)/t17-/m0/s1
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM402000
PNG
(5-[[5-[4-[(1-ethyl-4-piperidyl)methylamino]-2-meth...)
Show SMILES CCN1CCC(CNc2ccc(-c3cc(Nc4cnc(cn4)C#N)n[nH]3)c(OC)c2)CC1
Show InChI InChI=1S/C23H28N8O/c1-3-31-8-6-16(7-9-31)13-25-17-4-5-19(21(10-17)32-2)20-11-22(30-29-20)28-23-15-26-18(12-24)14-27-23/h4-5,10-11,14-16,25H,3,6-9,13H2,1-2H3,(H2,27,28,29,30)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM402017
PNG
(5-[[5-[4-[[(2R)-1-isopropylpyrrolidin-2-yl]methoxy...)
Show SMILES COc1cc(OC[C@H]2CCCN2C(C)C)ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1
Show InChI InChI=1S/C23H27N7O2/c1-15(2)30-8-4-5-17(30)14-32-18-6-7-19(21(9-18)31-3)20-10-22(29-28-20)27-23-13-25-16(11-24)12-26-23/h6-7,9-10,12-13,15,17H,4-5,8,14H2,1-3H3,(H2,26,27,28,29)/t17-/m1/s1
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM402019
PNG
(5-[[5-[4-[[(2S)-1-isopropylpyrrolidin-2-yl]methoxy...)
Show SMILES COc1cc(OC[C@@H]2CCCN2C(C)C)ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1
Show InChI InChI=1S/C23H27N7O2/c1-15(2)30-8-4-5-17(30)14-32-18-6-7-19(21(9-18)31-3)20-10-22(29-28-20)27-23-13-25-16(11-24)12-26-23/h6-7,9-10,12-13,15,17H,4-5,8,14H2,1-3H3,(H2,26,27,28,29)/t17-/m0/s1
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401903
PNG
(5-{5-[2-methoxy-4-(1-methyl-piperidin-4-yl)-phenyl...)
Show SMILES COc1cc(ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1)C1CCN(C)CC1
Show InChI InChI=1S/C21H23N7O/c1-28-7-5-14(6-8-28)15-3-4-17(19(9-15)29-2)18-10-20(27-26-18)25-21-13-23-16(11-22)12-24-21/h3-4,9-10,12-14H,5-8H2,1-2H3,(H2,24,25,26,27)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM402027
PNG
(5-[[5-[4-(4-isopropylpiperazin-1-yl)-2-fluoro-6-me...)
Show SMILES COc1cc(cc(F)c1-c1cc(Nc2cnc(cn2)C#N)n[nH]1)N1CCN(CC1)C(C)C
Show InChI InChI=1S/C22H25FN8O/c1-14(2)30-4-6-31(7-5-30)16-8-17(23)22(19(9-16)32-3)18-10-20(29-28-18)27-21-13-25-15(11-24)12-26-21/h8-10,12-14H,4-7H2,1-3H3,(H2,26,27,28,29)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401981
PNG
(5-[[5-[2-methoxy-4-[1-(2-methoxyethyl)-4-piperidyl...)
Show SMILES COCCN1CCC(CC1)c1ccc(-c2cc(Nc3cnc(cn3)C#N)n[nH]2)c(OC)c1
Show InChI InChI=1S/C23H27N7O2/c1-31-10-9-30-7-5-16(6-8-30)17-3-4-19(21(11-17)32-2)20-12-22(29-28-20)27-23-15-25-18(13-24)14-26-23/h3-4,11-12,14-16H,5-10H2,1-2H3,(H2,26,27,28,29)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401955
PNG
(5-[[5-[2-methoxy-4-[[methyl(tetrahydropyran-4-yl)a...)
Show SMILES COc1cc(CN(C)C2CCOCC2)ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1
Show InChI InChI=1S/C22H25N7O2/c1-29(17-5-7-31-8-6-17)14-15-3-4-18(20(9-15)30-2)19-10-21(28-27-19)26-22-13-24-16(11-23)12-25-22/h3-4,9-10,12-13,17H,5-8,14H2,1-2H3,(H2,25,26,27,28)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM402026
PNG
(5-[[5-[4-(4-ethylpiperazin-1-yl)-2-fluoro-6-methox...)
Show SMILES CCN1CCN(CC1)c1cc(F)c(-c2cc(Nc3cnc(cn3)C#N)n[nH]2)c(OC)c1
Show InChI InChI=1S/C21H23FN8O/c1-3-29-4-6-30(7-5-29)15-8-16(22)21(18(9-15)31-2)17-10-19(28-27-17)26-20-13-24-14(11-23)12-25-20/h8-10,12-13H,3-7H2,1-2H3,(H2,25,26,27,28)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401992
PNG
(5-[[5-[4-[[isopropyl(methyl)amino]methyl]-2-methox...)
Show SMILES COc1cc(CN(C)C(C)C)ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1
Show InChI InChI=1S/C20H23N7O/c1-13(2)27(3)12-14-5-6-16(18(7-14)28-4)17-8-19(26-25-17)24-20-11-22-15(9-21)10-23-20/h5-8,10-11,13H,12H2,1-4H3,(H2,23,24,25,26)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM402025
PNG
(5-[[5-[4-[(1-isopropyl-4-piperidyl)oxy]-2-methoxy-...)
Show SMILES COc1cc(OC2CCN(CC2)C(C)C)ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1
Show InChI InChI=1S/C23H27N7O2/c1-15(2)30-8-6-17(7-9-30)32-18-4-5-19(21(10-18)31-3)20-11-22(29-28-20)27-23-14-25-16(12-24)13-26-23/h4-5,10-11,13-15,17H,6-9H2,1-3H3,(H2,26,27,28,29)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401938
PNG
(5-[[5-(2-methoxy-4-piperazin-1-yl-phenyl)-1H-pyraz...)
Show SMILES Oc1cc(ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1)N1CCNCC1
Show InChI InChI=1S/C18H18N8O/c19-9-12-10-22-18(11-21-12)23-17-8-15(24-25-17)14-2-1-13(7-16(14)27)26-5-3-20-4-6-26/h1-2,7-8,10-11,20,27H,3-6H2,(H2,22,23,24,25)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401993
PNG
(5-[[5-[2-methoxy-4-(pyrrolidin-1-ylmethyl)phenyl]-...)
Show SMILES COc1cc(CN2CCCC2)ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1
Show InChI InChI=1S/C20H21N7O/c1-28-18-8-14(13-27-6-2-3-7-27)4-5-16(18)17-9-19(26-25-17)24-20-12-22-15(10-21)11-23-20/h4-5,8-9,11-12H,2-3,6-7,13H2,1H3,(H2,23,24,25,26)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM402016
PNG
(5-[[5-[4-[[(2R)-1-ethylpyrrolidin-2-yl]methoxy]-2-...)
Show SMILES CCN1CCC[C@@H]1COc1ccc(-c2cc(Nc3cnc(cn3)C#N)n[nH]2)c(OC)c1
Show InChI InChI=1S/C22H25N7O2/c1-3-29-8-4-5-16(29)14-31-17-6-7-18(20(9-17)30-2)19-10-21(28-27-19)26-22-13-24-15(11-23)12-25-22/h6-7,9-10,12-13,16H,3-5,8,14H2,1-2H3,(H2,25,26,27,28)/t16-/m1/s1
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401900
PNG
(5-(5-{4-[(4-fluoro-benzylamino)-methyl]-2-methoxy-...)
Show SMILES COc1cc(CNCc2ccc(F)cc2)ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1
Show InChI InChI=1S/C23H20FN7O/c1-32-21-8-16(12-26-11-15-2-5-17(24)6-3-15)4-7-19(21)20-9-22(31-30-20)29-23-14-27-18(10-25)13-28-23/h2-9,13-14,26H,11-12H2,1H3,(H2,28,29,30,31)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401982
PNG
(5-[[5-[4-(ethylaminomethyl)-2-methoxy-phenyl]-1H-p...)
Show SMILES CCNCc1ccc(-c2cc(Nc3cnc(cn3)C#N)n[nH]2)c(OC)c1
Show InChI InChI=1S/C18H19N7O/c1-3-20-9-12-4-5-14(16(6-12)26-2)15-7-17(25-24-15)23-18-11-21-13(8-19)10-22-18/h4-7,10-11,20H,3,9H2,1-2H3,(H2,22,23,24,25)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401979
PNG
(5-[[5-[4-(1-ethyl-3-fluoro-4-piperidyl)-2-methoxy-...)
Show SMILES CCN1CCC(C(F)C1)c1ccc(-c2cc(Nc3cnc(cn3)C#N)n[nH]2)c(OC)c1
Show InChI InChI=1/C22H24FN7O/c1-3-30-7-6-16(18(23)13-30)14-4-5-17(20(8-14)31-2)19-9-21(29-28-19)27-22-12-25-15(10-24)11-26-22/h4-5,8-9,11-12,16,18H,3,6-7,13H2,1-2H3,(H2,26,27,28,29)
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n/an/a 0.0590n/an/an/an/an/an/a



Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401921
PNG
(5-[[5-[2-methoxy-4-[(1-methyl-4-piperidyl)methoxy]...)
Show SMILES COc1cc(OCC2CCN(C)CC2)ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1
Show InChI InChI=1S/C22H25N7O2/c1-29-7-5-15(6-8-29)14-31-17-3-4-18(20(9-17)30-2)19-10-21(28-27-19)26-22-13-24-16(11-23)12-25-22/h3-4,9-10,12-13,15H,5-8,14H2,1-2H3,(H2,25,26,27,28)
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n/an/a 0.0680n/an/an/an/an/an/a



Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401949
PNG
(5-[[5-[2-methoxy-4-(4-piperidyloxy)phenyl]-1H-pyra...)
Show SMILES COc1cc(OC2CCNCC2)ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1
Show InChI InChI=1S/C20H21N7O2/c1-28-18-8-15(29-14-4-6-22-7-5-14)2-3-16(18)17-9-19(27-26-17)25-20-12-23-13(10-21)11-24-20/h2-3,8-9,11-12,14,22H,4-7H2,1H3,(H2,24,25,26,27)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401951
PNG
(5-[[5-[4-[(isopropylamino)methyl]-2-methoxy-phenyl...)
Show SMILES COc1cc(CNC(C)C)ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1
Show InChI InChI=1S/C19H21N7O/c1-12(2)21-9-13-4-5-15(17(6-13)27-3)16-7-18(26-25-16)24-19-11-22-14(8-20)10-23-19/h4-7,10-12,21H,9H2,1-3H3,(H2,23,24,25,26)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401925
PNG
(5-[[5-[2-methoxy-4-[(3S)-pyrrolidin-3-yl]oxy-pheny...)
Show SMILES COc1cc(O[C@H]2CCNC2)ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1
Show InChI InChI=1S/C19H19N7O2/c1-27-17-6-13(28-14-4-5-21-10-14)2-3-15(17)16-7-18(26-25-16)24-19-11-22-12(8-20)9-23-19/h2-3,6-7,9,11,14,21H,4-5,10H2,1H3,(H2,23,24,25,26)/t14-/m0/s1
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401901
PNG
(5-(5-{2-methoxy-4-[(2-morpholin-4-yl-ethylamino)-m...)
Show SMILES COc1cc(CNCCN2CCOCC2)ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1
Show InChI InChI=1S/C22H26N8O2/c1-31-20-10-16(13-24-4-5-30-6-8-32-9-7-30)2-3-18(20)19-11-21(29-28-19)27-22-15-25-17(12-23)14-26-22/h2-3,10-11,14-15,24H,4-9,13H2,1H3,(H2,26,27,28,29)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM402008
PNG
(5-[[5-(2-fluoro-6-methoxy-4-piperazin-1-yl-phenyl)...)
Show SMILES COc1cc(cc(F)c1-c1cc(Nc2cnc(cn2)C#N)n[nH]1)N1CCNCC1
Show InChI InChI=1S/C19H19FN8O/c1-29-16-7-13(28-4-2-22-3-5-28)6-14(20)19(16)15-8-17(27-26-15)25-18-11-23-12(9-21)10-24-18/h6-8,10-11,22H,2-5H2,1H3,(H2,24,25,26,27)
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n/an/a 0.0770n/an/an/an/an/an/a



Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401980
PNG
(5-[[5-[4-(3-fluoro-1-isopropyl-4-piperidyl)-2-meth...)
Show SMILES COc1cc(ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1)C1CCN(CC1F)C(C)C
Show InChI InChI=1/C23H26FN7O/c1-14(2)31-7-6-17(19(24)13-31)15-4-5-18(21(8-15)32-3)20-9-22(30-29-20)28-23-12-26-16(10-25)11-27-23/h4-5,8-9,11-12,14,17,19H,6-7,13H2,1-3H3,(H2,27,28,29,30)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401999
PNG
(5-[[5-[2-methoxy-4-[(1-methyl-4-piperidyl)methylam...)
Show SMILES COc1cc(NCC2CCN(C)CC2)ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1
Show InChI InChI=1S/C22H26N8O/c1-30-7-5-15(6-8-30)12-24-16-3-4-18(20(9-16)31-2)19-10-21(29-28-19)27-22-14-25-17(11-23)13-26-22/h3-4,9-10,13-15,24H,5-8,12H2,1-2H3,(H2,26,27,28,29)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM402032
PNG
(5-[[5-[4-(4-isobutylpiperazin-1-yl)-2-methoxy-phen...)
Show SMILES COc1cc(ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1)N1CCN(CC(C)C)CC1
Show InChI InChI=1S/C23H28N8O/c1-16(2)15-30-6-8-31(9-7-30)18-4-5-19(21(10-18)32-3)20-11-22(29-28-20)27-23-14-25-17(12-24)13-26-23/h4-5,10-11,13-14,16H,6-9,15H2,1-3H3,(H2,26,27,28,29)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401954
PNG
(2-[4-[4-[3-[(5-cyanopyrazin-2-yl)amino]-1H-pyrazol...)
Show SMILES COc1cc(ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1)C1CCN(CC(N)=O)CC1
Show InChI InChI=1S/C22H24N8O2/c1-32-19-8-15(14-4-6-30(7-5-14)13-20(24)31)2-3-17(19)18-9-21(29-28-18)27-22-12-25-16(10-23)11-26-22/h2-3,8-9,11-12,14H,4-7,13H2,1H3,(H2,24,31)(H2,26,27,28,29)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401908
PNG
(5-[[5-[2-methoxy-4-(2-morpholinoethylamino)phenyl]...)
Show SMILES COc1cc(NCCN2CCOCC2)ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1
Show InChI InChI=1S/C21H24N8O2/c1-30-19-10-15(23-4-5-29-6-8-31-9-7-29)2-3-17(19)18-11-20(28-27-18)26-21-14-24-16(12-22)13-25-21/h2-3,10-11,13-14,23H,4-9H2,1H3,(H2,25,26,27,28)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM402001
PNG
(5-[[5-[4-[(1-isopropyl-4-piperidyl)methylamino]-2-...)
Show SMILES COc1cc(NCC2CCN(CC2)C(C)C)ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1
Show InChI InChI=1S/C24H30N8O/c1-16(2)32-8-6-17(7-9-32)13-26-18-4-5-20(22(10-18)33-3)21-11-23(31-30-21)29-24-15-27-19(12-25)14-28-24/h4-5,10-11,14-17,26H,6-9,13H2,1-3H3,(H2,28,29,30,31)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401928
PNG
(5-[[5-[2-methoxy-4-(4-piperidylmethoxy)phenyl]-1H-...)
Show SMILES COc1cc(OCC2CCNCC2)ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1
Show InChI InChI=1S/C21H23N7O2/c1-29-19-8-16(30-13-14-4-6-23-7-5-14)2-3-17(19)18-9-20(28-27-18)26-21-12-24-15(10-22)11-25-21/h2-3,8-9,11-12,14,23H,4-7,13H2,1H3,(H2,25,26,27,28)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401898
PNG
(5-[5-(4-{[(S)-1-(4-fluoro-phenyl)-ethylamino]-meth...)
Show SMILES COc1cc(CN[C@@H](C)c2ccc(F)cc2)ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1
Show InChI InChI=1S/C24H22FN7O/c1-15(17-4-6-18(25)7-5-17)27-12-16-3-8-20(22(9-16)33-2)21-10-23(32-31-21)30-24-14-28-19(11-26)13-29-24/h3-10,13-15,27H,12H2,1-2H3,(H2,29,30,31,32)/t15-/m0/s1
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401952
PNG
(5-[[5-[4-(1-ethyl-4-piperidyl)-2-methoxy-phenyl]-1...)
Show SMILES CCN1CCC(CC1)c1ccc(-c2cc(Nc3cnc(cn3)C#N)n[nH]2)c(OC)c1
Show InChI InChI=1S/C22H25N7O/c1-3-29-8-6-15(7-9-29)16-4-5-18(20(10-16)30-2)19-11-21(28-27-19)26-22-14-24-17(12-23)13-25-22/h4-5,10-11,13-15H,3,6-9H2,1-2H3,(H2,25,26,27,28)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401953
PNG
(5-[[5-[4-(1-isopropyl-4-piperidyl)-2-methoxy-pheny...)
Show SMILES COc1cc(ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1)C1CCN(CC1)C(C)C
Show InChI InChI=1S/C23H27N7O/c1-15(2)30-8-6-16(7-9-30)17-4-5-19(21(10-17)31-3)20-11-22(29-28-20)27-23-14-25-18(12-24)13-26-23/h4-5,10-11,13-16H,6-9H2,1-3H3,(H2,26,27,28,29)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM402021
PNG
(5-[[5-[2-methoxy-4-[[[(3R)-tetrahydrofuran-3-yl]am...)
Show SMILES COc1cc(CN[C@@H]2CCOC2)ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1
Show InChI InChI=1S/C20H21N7O2/c1-28-18-6-13(9-22-14-4-5-29-12-14)2-3-16(18)17-7-19(27-26-17)25-20-11-23-15(8-21)10-24-20/h2-3,6-7,10-11,14,22H,4-5,9,12H2,1H3,(H2,24,25,26,27)/t14-/m1/s1
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401899
PNG
(5-[5-(4-{[(R)-1-(4-fluoro-phenyl)-ethylamino]-meth...)
Show SMILES COc1cc(CN[C@H](C)c2ccc(F)cc2)ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1
Show InChI InChI=1S/C24H22FN7O/c1-15(17-4-6-18(25)7-5-17)27-12-16-3-8-20(22(9-16)33-2)21-10-23(32-31-21)30-24-14-28-19(11-26)13-29-24/h3-10,13-15,27H,12H2,1-2H3,(H2,29,30,31,32)/t15-/m1/s1
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401995
PNG
(5-[[5-[2-methoxy-4-[[(2R)-1-methylpyrrolidin-2-yl]...)
Show SMILES COc1cc(OC[C@H]2CCCN2C)ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1
Show InChI InChI=1S/C21H23N7O2/c1-28-7-3-4-15(28)13-30-16-5-6-17(19(8-16)29-2)18-9-20(27-26-18)25-21-12-23-14(10-22)11-24-21/h5-6,8-9,11-12,15H,3-4,7,13H2,1-2H3,(H2,24,25,26,27)/t15-/m1/s1
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401975
PNG
(5-[[5-[4-(4-ethyl-1,4-diazepan-1-yl)-2-methoxy-phe...)
Show SMILES CCN1CCCN(CC1)c1ccc(-c2cc(Nc3cnc(cn3)C#N)n[nH]2)c(OC)c1
Show InChI InChI=1S/C22H26N8O/c1-3-29-7-4-8-30(10-9-29)17-5-6-18(20(11-17)31-2)19-12-21(28-27-19)26-22-15-24-16(13-23)14-25-22/h5-6,11-12,14-15H,3-4,7-10H2,1-2H3,(H2,25,26,27,28)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401929
PNG
(5-[[5-[2-methoxy-4-[[(1-methyl-4-piperidyl)amino]m...)
Show SMILES COc1cc(CNC2CCN(C)CC2)ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1
Show InChI InChI=1S/C22H26N8O/c1-30-7-5-16(6-8-30)24-12-15-3-4-18(20(9-15)31-2)19-10-21(29-28-19)27-22-14-25-17(11-23)13-26-22/h3-4,9-10,13-14,16,24H,5-8,12H2,1-2H3,(H2,26,27,28,29)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM402022
PNG
(5-[[5-[2-methoxy-4-[[[(3S)-tetrahydrofuran-3-yl]am...)
Show SMILES COc1cc(CN[C@H]2CCOC2)ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1
Show InChI InChI=1S/C20H21N7O2/c1-28-18-6-13(9-22-14-4-5-29-12-14)2-3-16(18)17-7-19(27-26-17)25-20-11-23-15(8-21)10-24-20/h2-3,6-7,10-11,14,22H,4-5,9,12H2,1H3,(H2,24,25,26,27)/t14-/m0/s1
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401968
PNG
(5-[[5-[4-(4-fluoro-4-piperidyl)-2-methoxy-phenyl]-...)
Show SMILES COc1cc(ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1)C1(F)CCNCC1
Show InChI InChI=1S/C20H20FN7O/c1-29-17-8-13(20(21)4-6-23-7-5-20)2-3-15(17)16-9-18(28-27-16)26-19-12-24-14(10-22)11-25-19/h2-3,8-9,11-12,23H,4-7H2,1H3,(H2,25,26,27,28)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM402024
PNG
(5-[[5-[4-[(1-ethyl-4-piperidyl)oxy]-2-methoxy-phen...)
Show SMILES CCN1CCC(CC1)Oc1ccc(-c2cc(Nc3cnc(cn3)C#N)n[nH]2)c(OC)c1
Show InChI InChI=1S/C22H25N7O2/c1-3-29-8-6-16(7-9-29)31-17-4-5-18(20(10-17)30-2)19-11-21(28-27-19)26-22-14-24-15(12-23)13-25-22/h4-5,10-11,13-14,16H,3,6-9H2,1-2H3,(H2,25,26,27,28)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401978
PNG
(5-[[5-[4-(4-fluoro-1-isopropyl-4-piperidyl)-2-meth...)
Show SMILES COc1cc(ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1)C1(F)CCN(CC1)C(C)C
Show InChI InChI=1S/C23H26FN7O/c1-15(2)31-8-6-23(24,7-9-31)16-4-5-18(20(10-16)32-3)19-11-21(30-29-19)28-22-14-26-17(12-25)13-27-22/h4-5,10-11,13-15H,6-9H2,1-3H3,(H2,27,28,29,30)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401915
PNG
(5-[[5-[2-methoxy-4-(4-methyl-1,4-diazepan-1-yl)phe...)
Show SMILES COc1cc(ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1)N1CCCN(C)CC1
Show InChI InChI=1S/C21H24N8O/c1-28-6-3-7-29(9-8-28)16-4-5-17(19(10-16)30-2)18-11-20(27-26-18)25-21-14-23-15(12-22)13-24-21/h4-5,10-11,13-14H,3,6-9H2,1-2H3,(H2,24,25,26,27)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401946
PNG
(5-[[5-[4-(1,4-diazepan-1-yl)-2-methoxy-phenyl]-1H-...)
Show SMILES COc1cc(ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1)N1CCCNCC1
Show InChI InChI=1S/C20H22N8O/c1-29-18-9-15(28-7-2-5-22-6-8-28)3-4-16(18)17-10-19(27-26-17)25-20-13-23-14(11-21)12-24-20/h3-4,9-10,12-13,22H,2,5-8H2,1H3,(H2,24,25,26,27)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM402023
PNG
(5-[[5-[4-[(3R)-4-isopropyl-3-methyl-piperazin-1-yl...)
Show SMILES COc1cc(ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1)N1CCN(C(C)C)[C@H](C)C1
Show InChI InChI=1S/C23H28N8O/c1-15(2)31-8-7-30(14-16(31)3)18-5-6-19(21(9-18)32-4)20-10-22(29-28-20)27-23-13-25-17(11-24)12-26-23/h5-6,9-10,12-13,15-16H,7-8,14H2,1-4H3,(H2,26,27,28,29)/t16-/m1/s1
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401996
PNG
(5-[[5-[2-methoxy-4-[[(2S)-1-methylpyrrolidin-2-yl]...)
Show SMILES COc1cc(OC[C@@H]2CCCN2C)ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1
Show InChI InChI=1S/C21H23N7O2/c1-28-7-3-4-15(28)13-30-16-5-6-17(19(8-16)29-2)18-9-20(27-26-18)25-21-12-23-14(10-22)11-24-21/h5-6,8-9,11-12,15H,3-4,7,13H2,1-2H3,(H2,24,25,26,27)/t15-/m0/s1
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401920
PNG
(5-[[5-[2-methoxy-4-[(1-methyl-4-piperidyl)oxy]phen...)
Show SMILES COc1cc(OC2CCN(C)CC2)ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1
Show InChI InChI=1S/C21H23N7O2/c1-28-7-5-15(6-8-28)30-16-3-4-17(19(9-16)29-2)18-10-20(27-26-18)25-21-13-23-14(11-22)12-24-21/h3-4,9-10,12-13,15H,5-8H2,1-2H3,(H2,24,25,26,27)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401932
PNG
(5-[[5-[2-methoxy-4-(1-methyl-3-piperidyl)phenyl]-1...)
Show SMILES COc1cc(ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1)C1CCCN(C)C1
Show InChI InChI=1/C21H23N7O/c1-28-7-3-4-15(13-28)14-5-6-17(19(8-14)29-2)18-9-20(27-26-18)25-21-12-23-16(10-22)11-24-21/h5-6,8-9,11-12,15H,3-4,7,13H2,1-2H3,(H2,24,25,26,27)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401958
PNG
(5-[[5-[4-(3-fluoro-1-methyl-azetidin-3-yl)-2-metho...)
Show SMILES COc1cc(ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1)C1(F)CN(C)C1
Show InChI InChI=1S/C19H18FN7O/c1-27-10-19(20,11-27)12-3-4-14(16(5-12)28-2)15-6-17(26-25-15)24-18-9-22-13(7-21)8-23-18/h3-6,8-9H,10-11H2,1-2H3,(H2,23,24,25,26)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401969
PNG
(5-[[5-[4-(3-fluoroazetidin-3-yl)-2-methoxy-phenyl]...)
Show SMILES COc1cc(ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1)C1(F)CNC1
Show InChI InChI=1S/C18H16FN7O/c1-27-15-4-11(18(19)9-21-10-18)2-3-13(15)14-5-16(26-25-14)24-17-8-22-12(6-20)7-23-17/h2-5,7-8,21H,9-10H2,1H3,(H2,23,24,25,26)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM402012
PNG
(5-[[5-[2,6-dimethoxy-4-(4-methylpiperazin-1-yl)phe...)
Show SMILES COc1cc(cc(OC)c1-c1cc(Nc2cnc(cn2)C#N)n[nH]1)N1CCN(C)CC1
Show InChI InChI=1S/C21H24N8O2/c1-28-4-6-29(7-5-28)15-8-17(30-2)21(18(9-15)31-3)16-10-19(27-26-16)25-20-13-23-14(11-22)12-24-20/h8-10,12-13H,4-7H2,1-3H3,(H2,24,25,26,27)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401976
PNG
(5-[[5-[4-(4-isopropyl-1,4-diazepan-1-yl)-2-methoxy...)
Show SMILES COc1cc(ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1)N1CCCN(CC1)C(C)C
Show InChI InChI=1S/C23H28N8O/c1-16(2)30-7-4-8-31(10-9-30)18-5-6-19(21(11-18)32-3)20-12-22(29-28-20)27-23-15-25-17(13-24)14-26-23/h5-6,11-12,14-16H,4,7-10H2,1-3H3,(H2,26,27,28,29)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401927
PNG
(5-[[5-[2-methoxy-4-[(1-methylpyrrolidin-2-yl)metho...)
Show SMILES COc1cc(OCC2CCCN2C)ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1
Show InChI InChI=1/C21H23N7O2/c1-28-7-3-4-15(28)13-30-16-5-6-17(19(8-16)29-2)18-9-20(27-26-18)25-21-12-23-14(10-22)11-24-21/h5-6,8-9,11-12,15H,3-4,7,13H2,1-2H3,(H2,24,25,26,27)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401926
PNG
(5-[[5-[2-methoxy-4-(pyrrolidin-2-ylmethoxy)phenyl]...)
Show SMILES COc1cc(OCC2CCCN2)ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1
Show InChI InChI=1/C20H21N7O2/c1-28-18-7-15(29-12-13-3-2-6-22-13)4-5-16(18)17-8-19(27-26-17)25-20-11-23-14(9-21)10-24-20/h4-5,7-8,10-11,13,22H,2-3,6,12H2,1H3,(H2,24,25,26,27)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401991
PNG
(5-[[5-[4-[1-(2-hydroxyethyl)-4-piperidyl]-2-methox...)
Show SMILES COc1cc(ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1)C1CCN(CCO)CC1
Show InChI InChI=1S/C22H25N7O2/c1-31-20-10-16(15-4-6-29(7-5-15)8-9-30)2-3-18(20)19-11-21(28-27-19)26-22-14-24-17(12-23)13-25-22/h2-3,10-11,13-15,30H,4-9H2,1H3,(H2,25,26,27,28)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401987
PNG
(5-[[5-[4-[(3R)-1-isopropylpyrrolidin-3-yl]oxy-2-me...)
Show SMILES COc1cc(O[C@@H]2CCN(C2)C(C)C)ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1
Show InChI InChI=1S/C22H25N7O2/c1-14(2)29-7-6-17(13-29)31-16-4-5-18(20(8-16)30-3)19-9-21(28-27-19)26-22-12-24-15(10-23)11-25-22/h4-5,8-9,11-12,14,17H,6-7,13H2,1-3H3,(H2,25,26,27,28)/t17-/m1/s1
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401956
PNG
(5-[[5-[4-(4-fluoro-1-methyl-4-piperidyl)-2-methoxy...)
Show SMILES COc1cc(ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1)C1(F)CCN(C)CC1
Show InChI InChI=1S/C21H22FN7O/c1-29-7-5-21(22,6-8-29)14-3-4-16(18(9-14)30-2)17-10-19(28-27-17)26-20-13-24-15(11-23)12-25-20/h3-4,9-10,12-13H,5-8H2,1-2H3,(H2,25,26,27,28)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM402011
PNG
(5-[[5-(2,6-dimethoxy-4-piperazin-1-yl-phenyl)-1H-p...)
Show SMILES COc1cc(cc(OC)c1-c1cc(Nc2cnc(cn2)C#N)n[nH]1)N1CCNCC1
Show InChI InChI=1S/C20H22N8O2/c1-29-16-7-14(28-5-3-22-4-6-28)8-17(30-2)20(16)15-9-18(27-26-15)25-19-12-23-13(10-21)11-24-19/h7-9,11-12,22H,3-6H2,1-2H3,(H2,24,25,26,27)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401973
PNG
(5-[[5-[4-(4-isopropylpiperazin-1-yl)-2-methoxy-phe...)
Show SMILES COc1cc(ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1)N1CCN(CC1)C(C)C
Show InChI InChI=1S/C22H26N8O/c1-15(2)29-6-8-30(9-7-29)17-4-5-18(20(10-17)31-3)19-11-21(28-27-19)26-22-14-24-16(12-23)13-25-22/h4-5,10-11,13-15H,6-9H2,1-3H3,(H2,25,26,27,28)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM402037
PNG
(5-[[5-[4-[(2R)-4-isopropylmorpholin-2-yl]-2-methox...)
Show SMILES COc1cc(ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1)[C@@H]1CN(CCO1)C(C)C
Show InChI InChI=1S/C22H25N7O2/c1-14(2)29-6-7-31-20(13-29)15-4-5-17(19(8-15)30-3)18-9-21(28-27-18)26-22-12-24-16(10-23)11-25-22/h4-5,8-9,11-12,14,20H,6-7,13H2,1-3H3,(H2,25,26,27,28)/t20-/m0/s1
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401964
PNG
(5-[[5-[2-methoxy-4-[(tetrahydrofuran-3-ylamino)met...)
Show SMILES COc1cc(CNC2CCOC2)ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1
Show InChI InChI=1/C20H21N7O2/c1-28-18-6-13(9-22-14-4-5-29-12-14)2-3-16(18)17-7-19(27-26-17)25-20-11-23-15(8-21)10-24-20/h2-3,6-7,10-11,14,22H,4-5,9,12H2,1H3,(H2,24,25,26,27)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401994
PNG
(5-[[5-[2-methoxy-4-(morpholinomethyl)phenyl]-1H-py...)
Show SMILES COc1cc(CN2CCOCC2)ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1
Show InChI InChI=1S/C20H21N7O2/c1-28-18-8-14(13-27-4-6-29-7-5-27)2-3-16(18)17-9-19(26-25-17)24-20-12-22-15(10-21)11-23-20/h2-3,8-9,11-12H,4-7,13H2,1H3,(H2,23,24,25,26)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM402013
PNG
(5-[[5-[4-[[(3R)-3-fluoropyrrolidin-1-yl]methyl]-2-...)
Show SMILES COc1cc(CN2CC[C@@H](F)C2)ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1
Show InChI InChI=1S/C20H20FN7O/c1-29-18-6-13(11-28-5-4-14(21)12-28)2-3-16(18)17-7-19(27-26-17)25-20-10-23-15(8-22)9-24-20/h2-3,6-7,9-10,14H,4-5,11-12H2,1H3,(H2,24,25,26,27)/t14-/m1/s1
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401998
PNG
(5-[[5-[4[1-(2-fluoroethyl)-4-piperidyl]-2-methoxy-...)
Show SMILES COc1cc(ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1)C1CCN(CCF)CC1
Show InChI InChI=1S/C22H24FN7O/c1-31-20-10-16(15-4-7-30(8-5-15)9-6-23)2-3-18(20)19-11-21(29-28-19)27-22-14-25-17(12-24)13-26-22/h2-3,10-11,13-15H,4-9H2,1H3,(H2,26,27,28,29)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401910
PNG
(5-[[5-[2-methoxy-4-[[[(1R)-1-methyl-2-morpholino-e...)
Show SMILES COc1cc(CN[C@H](C)CN2CCOCC2)ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1
Show InChI InChI=1S/C23H28N8O2/c1-16(15-31-5-7-33-8-6-31)25-12-17-3-4-19(21(9-17)32-2)20-10-22(30-29-20)28-23-14-26-18(11-24)13-27-23/h3-4,9-10,13-14,16,25H,5-8,12,15H2,1-2H3,(H2,27,28,29,30)/t16-/m1/s1
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401931
PNG
(5-[[5-[2-methoxy-4-(3-piperidyl)phenyl]-1H-pyrazol...)
Show SMILES COc1cc(ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1)C1CCCNC1
Show InChI InChI=1/C20H21N7O/c1-28-18-7-13(14-3-2-6-22-10-14)4-5-16(18)17-8-19(27-26-17)25-20-12-23-15(9-21)11-24-20/h4-5,7-8,11-12,14,22H,2-3,6,10H2,1H3,(H2,24,25,26,27)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401986
PNG
(5-[[5-[4-[(3S)-1-isopropylpyrrolidin-3-yl]oxy-2-me...)
Show SMILES COc1cc(O[C@H]2CCN(C2)C(C)C)ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1
Show InChI InChI=1S/C22H25N7O2/c1-14(2)29-7-6-17(13-29)31-16-4-5-18(20(8-16)30-3)19-9-21(28-27-19)26-22-12-24-15(10-23)11-25-22/h4-5,8-9,11-12,14,17H,6-7,13H2,1-3H3,(H2,25,26,27,28)/t17-/m0/s1
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401972
PNG
(5-[[5-[4-(4-ethylpiperazin-1-yl)-2-methoxy-phenyl]...)
Show SMILES CCN1CCN(CC1)c1ccc(-c2cc(Nc3cnc(cn3)C#N)n[nH]2)c(OC)c1
Show InChI InChI=1S/C21H24N8O/c1-3-28-6-8-29(9-7-28)16-4-5-17(19(10-16)30-2)18-11-20(27-26-18)25-21-14-23-15(12-22)13-24-21/h4-5,10-11,13-14H,3,6-9H2,1-2H3,(H2,24,25,26,27)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401896
PNG
(5-{5-[4-(2-benzylamino-ethyl)-2-methoxy-phenyl]-1H...)
Show SMILES COc1cc(CCNCc2ccccc2)ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1
Show InChI InChI=1S/C24H23N7O/c1-32-22-11-17(9-10-26-14-18-5-3-2-4-6-18)7-8-20(22)21-12-23(31-30-21)29-24-16-27-19(13-25)15-28-24/h2-8,11-12,15-16,26H,9-10,14H2,1H3,(H2,28,29,30,31)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM402006
PNG
(5-[[5-[4-[(1-ethyl-4-piperidyl)oxymethyl]-2-methox...)
Show SMILES CCN1CCC(CC1)OCc1ccc(-c2cc(Nc3cnc(cn3)C#N)n[nH]2)c(OC)c1
Show InChI InChI=1S/C23H27N7O2/c1-3-30-8-6-18(7-9-30)32-15-16-4-5-19(21(10-16)31-2)20-11-22(29-28-20)27-23-14-25-17(12-24)13-26-23/h4-5,10-11,13-14,18H,3,6-9,15H2,1-2H3,(H2,26,27,28,29)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401895
PNG
(5-{5-[4-(benzylamino-methyl)-2-methoxy-phenyl]-1H-...)
Show SMILES COc1cc(CNCc2ccccc2)ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1
Show InChI InChI=1S/C23H21N7O/c1-31-21-9-17(13-25-12-16-5-3-2-4-6-16)7-8-19(21)20-10-22(30-29-20)28-23-15-26-18(11-24)14-27-23/h2-10,14-15,25H,12-13H2,1H3,(H2,27,28,29,30)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401934
PNG
(5-[[5-[2-methoxy-4-[(3S)-1-methylpyrrolidin-3-yl]o...)
Show SMILES COc1cc(O[C@H]2CCN(C)C2)ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1
Show InChI InChI=1S/C20H21N7O2/c1-27-6-5-15(12-27)29-14-3-4-16(18(7-14)28-2)17-8-19(26-25-17)24-20-11-22-13(9-21)10-23-20/h3-4,7-8,10-11,15H,5-6,12H2,1-2H3,(H2,23,24,25,26)/t15-/m0/s1
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401939
PNG
(5-[[5-[4-[(2S,6S)-2,6-dimethyl-4-piperidyl]-2-meth...)
Show SMILES COc1cc(ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1)C1C[C@H](C)N[C@@H](C)C1
Show InChI InChI=1S/C22H25N7O/c1-13-6-16(7-14(2)26-13)15-4-5-18(20(8-15)30-3)19-9-21(29-28-19)27-22-12-24-17(10-23)11-25-22/h4-5,8-9,11-14,16,26H,6-7H2,1-3H3,(H2,25,27,28,29)/t13-,14-/m0/s1
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM402007
PNG
(5-[[5-[4-[(1-isopropyl-4-piperidyl)oxymethyl]-2-me...)
Show SMILES COc1cc(COC2CCN(CC2)C(C)C)ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1
Show InChI InChI=1S/C24H29N7O2/c1-16(2)31-8-6-19(7-9-31)33-15-17-4-5-20(22(10-17)32-3)21-11-23(30-29-21)28-24-14-26-18(12-25)13-27-24/h4-5,10-11,13-14,16,19H,6-9,15H2,1-3H3,(H2,27,28,29,30)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401916
PNG
(5-[[5-[2-methoxy-4-(1-methyl-4-piperidyl)phenyl]-1...)
Show SMILES COc1cc(ccc1-c1cc(Nc2ccc(nc2)C#N)n[nH]1)C1CCN(C)CC1
Show InChI InChI=1S/C22H24N6O/c1-28-9-7-15(8-10-28)16-3-6-19(21(11-16)29-2)20-12-22(27-26-20)25-18-5-4-17(13-23)24-14-18/h3-6,11-12,14-15H,7-10H2,1-2H3,(H2,25,26,27)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM402014
PNG
(5-[[5-[2-methoxy-4-[[(3S)-3-methoxypyrrolidin-1-yl...)
Show SMILES CO[C@H]1CCN(Cc2ccc(-c3cc(Nc4cnc(cn4)C#N)n[nH]3)c(OC)c2)C1
Show InChI InChI=1S/C21H23N7O2/c1-29-16-5-6-28(13-16)12-14-3-4-17(19(7-14)30-2)18-8-20(27-26-18)25-21-11-23-15(9-22)10-24-21/h3-4,7-8,10-11,16H,5-6,12-13H2,1-2H3,(H2,24,25,26,27)/t16-/m0/s1
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401977
PNG
(5-[[5-[4-(1-ethyl-4-fluoro-4-piperidyl)-2-methoxy-...)
Show SMILES CCN1CCC(F)(CC1)c1ccc(-c2cc(Nc3cnc(cn3)C#N)n[nH]2)c(OC)c1
Show InChI InChI=1S/C22H24FN7O/c1-3-30-8-6-22(23,7-9-30)15-4-5-17(19(10-15)31-2)18-11-20(29-28-18)27-21-14-25-16(12-24)13-26-21/h4-5,10-11,13-14H,3,6-9H2,1-2H3,(H2,26,27,28,29)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401924
PNG
(5-[[5-[5-fluoro-2-methoxy-4-(1-methyl-4-piperidyl)...)
Show SMILES COc1cc(C2CCN(C)CC2)c(F)cc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1
Show InChI InChI=1S/C21H22FN7O/c1-29-5-3-13(4-6-29)15-8-19(30-2)16(7-17(15)22)18-9-20(28-27-18)26-21-12-24-14(10-23)11-25-21/h7-9,11-13H,3-6H2,1-2H3,(H2,25,26,27,28)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM402005
PNG
(5-[[5-[2-methoxy-4-[(1-methyl-4-piperidyl)oxymethy...)
Show SMILES COc1cc(COC2CCN(C)CC2)ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1
Show InChI InChI=1S/C22H25N7O2/c1-29-7-5-17(6-8-29)31-14-15-3-4-18(20(9-15)30-2)19-10-21(28-27-19)26-22-13-24-16(11-23)12-25-22/h3-4,9-10,12-13,17H,5-8,14H2,1-2H3,(H2,25,26,27,28)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM402015
PNG
(5-[[5-[2-methoxy-4-[[(3R)-3-methoxypyrrolidin-1-yl...)
Show SMILES CO[C@@H]1CCN(Cc2ccc(-c3cc(Nc4cnc(cn4)C#N)n[nH]3)c(OC)c2)C1
Show InChI InChI=1S/C21H23N7O2/c1-29-16-5-6-28(13-16)12-14-3-4-17(19(7-14)30-2)18-8-20(27-26-18)25-21-11-23-15(9-22)10-24-21/h3-4,7-8,10-11,16H,5-6,12-13H2,1-2H3,(H2,24,25,26,27)/t16-/m1/s1
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401965
PNG
(5-[[5-[2-methoxy-4-[[methyl(tetrahydrofuran-3-yl)a...)
Show SMILES COc1cc(CN(C)C2CCOC2)ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1
Show InChI InChI=1/C21H23N7O2/c1-28(16-5-6-30-13-16)12-14-3-4-17(19(7-14)29-2)18-8-20(27-26-18)25-21-11-23-15(9-22)10-24-21/h3-4,7-8,10-11,16H,5-6,12-13H2,1-2H3,(H2,24,25,26,27)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401912
PNG
(5-[[5-[2-methoxy-4-(4-piperidyl)phenyl]-1H-pyrazol...)
Show SMILES COc1cc(ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1)C1CCNCC1
Show InChI InChI=1S/C20H21N7O/c1-28-18-8-14(13-4-6-22-7-5-13)2-3-16(18)17-9-19(27-26-17)25-20-12-23-15(10-21)11-24-20/h2-3,8-9,11-13,22H,4-7H2,1H3,(H2,24,25,26,27)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401911
PNG
(5-[[5-[4-[[(1,1-dimethyl-2-morpholino-ethyl)amino]...)
Show SMILES COc1cc(CNC(C)(C)CN2CCOCC2)ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1
Show InChI InChI=1S/C24H30N8O2/c1-24(2,16-32-6-8-34-9-7-32)28-13-17-4-5-19(21(10-17)33-3)20-11-22(31-30-20)29-23-15-26-18(12-25)14-27-23/h4-5,10-11,14-15,28H,6-9,13,16H2,1-3H3,(H2,27,29,30,31)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401909
PNG
(5-[[5-[4-[1-[2-(dimethylamino)acetyl]-4-piperidyl]...)
Show SMILES COc1cc(ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1)C1CCN(CC1)C(=O)CN(C)C
Show InChI InChI=1S/C24H28N8O2/c1-31(2)15-24(33)32-8-6-16(7-9-32)17-4-5-19(21(10-17)34-3)20-11-22(30-29-20)28-23-14-26-18(12-25)13-27-23/h4-5,10-11,13-14,16H,6-9,15H2,1-3H3,(H2,27,28,29,30)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401907
PNG
(5-[[5-[2-methoxy-4-[[methyl(2-morpholinoethyl)amin...)
Show SMILES COc1cc(CN(C)CCN2CCOCC2)ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1
Show InChI InChI=1S/C23H28N8O2/c1-30(5-6-31-7-9-33-10-8-31)16-17-3-4-19(21(11-17)32-2)20-12-22(29-28-20)27-23-15-25-18(13-24)14-26-23/h3-4,11-12,14-15H,5-10,16H2,1-2H3,(H2,26,27,28,29)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401983
PNG
(5-[[5-[4-[(cyclopropylamino)methyl]-2-methoxy-phen...)
Show SMILES COc1cc(CNC2CC2)ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1
Show InChI InChI=1S/C19H19N7O/c1-27-17-6-12(9-21-13-3-4-13)2-5-15(17)16-7-18(26-25-16)24-19-11-22-14(8-20)10-23-19/h2,5-7,10-11,13,21H,3-4,9H2,1H3,(H2,23,24,25,26)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401966
PNG
(5-[[5-[2-methoxy-4-(tetrahydropyran-4-ylmethylamin...)
Show SMILES COc1cc(NCC2CCOCC2)ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1
Show InChI InChI=1S/C21H23N7O2/c1-29-19-8-15(23-11-14-4-6-30-7-5-14)2-3-17(19)18-9-20(28-27-18)26-21-13-24-16(10-22)12-25-21/h2-3,8-9,12-14,23H,4-7,11H2,1H3,(H2,25,26,27,28)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401923
PNG
(5-[[5-[2-methoxy-4-[(2-pyridylamino)methyl]phenyl]...)
Show SMILES COc1cc(CNc2ccccn2)ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1
Show InChI InChI=1S/C21H18N8O/c1-30-18-8-14(11-25-19-4-2-3-7-23-19)5-6-16(18)17-9-20(29-28-17)27-21-13-24-15(10-22)12-26-21/h2-9,12-13H,11H2,1H3,(H,23,25)(H2,26,27,28,29)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401971
PNG
(5-[[5-(2-methoxy-4-morpholino-phenyl)-1H-pyrazol-3...)
Show SMILES COc1cc(ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1)N1CCOCC1
Show InChI InChI=1S/C19H19N7O2/c1-27-17-8-14(26-4-6-28-7-5-26)2-3-15(17)16-9-18(25-24-16)23-19-12-21-13(10-20)11-22-19/h2-3,8-9,11-12H,4-7H2,1H3,(H2,22,23,24,25)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401988
PNG
(5-[[5-[4-[(3(R,S),4(R,S))-3-fluoro-1-methyl-4-pipe...)
Show SMILES COc1cc(ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1)[C@H]1CCN(C)C[C@@H]1C
Show InChI InChI=1S/C22H25N7O/c1-14-13-29(2)7-6-17(14)15-4-5-18(20(8-15)30-3)19-9-21(28-27-19)26-22-12-24-16(10-23)11-25-22/h4-5,8-9,11-12,14,17H,6-7,13H2,1-3H3,(H2,25,26,27,28)/t14-,17-/m0/s1
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401944
PNG
(5-[[5-[2-methoxy-4-(4-piperidyl)phenyl]-1H-pyrazol...)
Show SMILES COc1cc(ccc1-c1cc(Nc2ccc(nc2)C#N)n[nH]1)C1CCNCC1
Show InChI InChI=1S/C21H22N6O/c1-28-20-10-15(14-6-8-23-9-7-14)2-5-18(20)19-11-21(27-26-19)25-17-4-3-16(12-22)24-13-17/h2-5,10-11,13-14,23H,6-9H2,1H3,(H2,25,26,27)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401933
PNG
(5-[[5-[2-methoxy-4-(1-methyl-2-piperidyl)phenyl]-1...)
Show SMILES COc1cc(ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1)C1CCCCN1C
Show InChI InChI=1/C21H23N7O/c1-28-8-4-3-5-18(28)14-6-7-16(19(9-14)29-2)17-10-20(27-26-17)25-21-13-23-15(11-22)12-24-21/h6-7,9-10,12-13,18H,3-5,8H2,1-2H3,(H2,24,25,26,27)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401950
PNG
(5-[[5-[5-fluoro-2-methoxy-4-(4-piperidyl)phenyl]-1...)
Show SMILES COc1cc(C2CCNCC2)c(F)cc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1
Show InChI InChI=1S/C20H20FN7O/c1-29-18-7-14(12-2-4-23-5-3-12)16(21)6-15(18)17-8-19(28-27-17)26-20-11-24-13(9-22)10-25-20/h6-8,10-12,23H,2-5H2,1H3,(H2,25,26,27,28)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401967
PNG
(5-[[5-[2-methoxy-4-(tetrahydropyran-4-ylmethoxy)ph...)
Show SMILES COc1cc(OCC2CCOCC2)ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1
Show InChI InChI=1S/C21H22N6O3/c1-28-19-8-16(30-13-14-4-6-29-7-5-14)2-3-17(19)18-9-20(27-26-18)25-21-12-23-15(10-22)11-24-21/h2-3,8-9,11-12,14H,4-7,13H2,1H3,(H2,24,25,26,27)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401905
PNG
(N-[[4-[3-[(5-cyanopyrazin-2-yl)amino]-1H-pyrazol-5...)
Show SMILES COc1cc(CNC(=O)C2CC2)ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1
Show InChI InChI=1S/C20H19N7O2/c1-29-17-6-12(9-24-20(28)13-3-4-13)2-5-15(17)16-7-18(27-26-16)25-19-11-22-14(8-21)10-23-19/h2,5-7,10-11,13H,3-4,9H2,1H3,(H,24,28)(H2,23,25,26,27)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401936
PNG
(5-chloro-N-[5-[2-methoxy-4-(1-methyl-4-piperidyl)p...)
Show SMILES COc1cc(ccc1-c1cc(Nc2cnc(Cl)cn2)n[nH]1)C1CCN(C)CC1
Show InChI InChI=1S/C20H23ClN6O/c1-27-7-5-13(6-8-27)14-3-4-15(17(9-14)28-2)16-10-19(26-25-16)24-20-12-22-18(21)11-23-20/h3-4,9-13H,5-8H2,1-2H3,(H2,23,24,25,26)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401970
PNG
(5-[[5-[2-methoxy-4-[(3R)-1-methylpyrrolidin-3-yl]o...)
Show SMILES COc1cc(O[C@@H]2CCN(C)C2)ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1
Show InChI InChI=1S/C20H21N7O2/c1-27-6-5-15(12-27)29-14-3-4-16(18(7-14)28-2)17-8-19(26-25-17)24-20-11-22-13(9-21)10-23-20/h3-4,7-8,10-11,15H,5-6,12H2,1-2H3,(H2,23,24,25,26)/t15-/m1/s1
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401935
PNG
(5-chloro-N-[5-[2-methoxy-4-(4-piperidyl)phenyl]-1H...)
Show SMILES COc1cc(ccc1-c1cc(Nc2cnc(Cl)cn2)n[nH]1)C1CCNCC1
Show InChI InChI=1S/C19H21ClN6O/c1-27-16-8-13(12-4-6-21-7-5-12)2-3-14(16)15-9-18(26-25-15)24-19-11-22-17(20)10-23-19/h2-3,8-12,21H,4-7H2,1H3,(H2,23,24,25,26)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401930
PNG
(5-[[5-[2-isopropoxy-4-(1-methyl-4-piperidyl)phenyl...)
Show SMILES CC(C)Oc1cc(ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1)C1CCN(C)CC1
Show InChI InChI=1S/C23H27N7O/c1-15(2)31-21-10-17(16-6-8-30(3)9-7-16)4-5-19(21)20-11-22(29-28-20)27-23-14-25-18(12-24)13-26-23/h4-5,10-11,13-16H,6-9H2,1-3H3,(H2,26,27,28,29)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401989
PNG
(5-[[5-[4-(3,3-difluoro-1-methyl-4-piperidyl)-2-met...)
Show SMILES COc1cc(ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1)C1CCN(C)CC1(F)F
Show InChI InChI=1/C21H21F2N7O/c1-30-6-5-16(21(22,23)12-30)13-3-4-15(18(7-13)31-2)17-8-19(29-28-17)27-20-11-25-14(9-24)10-26-20/h3-4,7-8,10-11,16H,5-6,12H2,1-2H3,(H2,26,27,28,29)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401940
PNG
(5-[[5-(2-methoxy-4-tetrahydropyran-4-yl-phenyl)-1H...)
Show SMILES COc1cc(ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1)C1CCOCC1
Show InChI InChI=1S/C20H20N6O2/c1-27-18-8-14(13-4-6-28-7-5-13)2-3-16(18)17-9-19(26-25-17)24-20-12-22-15(10-21)11-23-20/h2-3,8-9,11-13H,4-7H2,1H3,(H2,23,24,25,26)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401990
PNG
(5-[[5-[4-(1-ethyl-3,3-difluoro-4-piperidyl)-2-meth...)
Show SMILES CCN1CCC(c2ccc(-c3cc(Nc4cnc(cn4)C#N)n[nH]3)c(OC)c2)C(F)(F)C1
Show InChI InChI=1/C22H23F2N7O/c1-3-31-7-6-17(22(23,24)13-31)14-4-5-16(19(8-14)32-2)18-9-20(30-29-18)28-21-12-26-15(10-25)11-27-21/h4-5,8-9,11-12,17H,3,6-7,13H2,1-2H3,(H2,27,28,29,30)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401959
PNG
(5-[[5-[5-chloro-2-methoxy-4-(1-methyl-4-piperidyl)...)
Show SMILES COc1cc(C2CCN(C)CC2)c(Cl)cc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1
Show InChI InChI=1S/C21H22ClN7O/c1-29-5-3-13(4-6-29)15-8-19(30-2)16(7-17(15)22)18-9-20(28-27-18)26-21-12-24-14(10-23)11-25-21/h7-9,11-13H,3-6H2,1-2H3,(H2,25,26,27,28)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401897
PNG
(5-{5-[4-(benzylamino-methyl)-phenyl]-1H-pyrazol-3-...)
Show SMILES N#Cc1cnc(Nc2cc([nH]n2)-c2ccc(CNCc3ccccc3)cc2)cn1
Show InChI InChI=1S/C22H19N7/c23-11-19-14-26-22(15-25-19)27-21-10-20(28-29-21)18-8-6-17(7-9-18)13-24-12-16-4-2-1-3-5-16/h1-10,14-15,24H,12-13H2,(H2,26,27,28,29)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401913
PNG
(5-[[5-[2-fluoro-4-(1-methyl-4-piperidyl)phenyl]-1H...)
Show SMILES CN1CCC(CC1)c1ccc(-c2cc(Nc3cnc(cn3)C#N)n[nH]2)c(F)c1
Show InChI InChI=1S/C20H20FN7/c1-28-6-4-13(5-7-28)14-2-3-16(17(21)8-14)18-9-19(27-26-18)25-20-12-23-15(10-22)11-24-20/h2-3,8-9,11-13H,4-7H2,1H3,(H2,24,25,26,27)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401894
PNG
(5-[5-(4-benzylamino-2-methoxy-phenyl)-1H-pyrazol-3...)
Show SMILES COc1cc(NCc2ccccc2)ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1
Show InChI InChI=1S/C22H19N7O/c1-30-20-9-16(24-12-15-5-3-2-4-6-15)7-8-18(20)19-10-21(29-28-19)27-22-14-25-17(11-23)13-26-22/h2-10,13-14,24H,12H2,1H3,(H2,26,27,28,29)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401893
PNG
(5-[5-(4-benzylamino-2,6-dimethoxy-phenyl)-1H-pyraz...)
Show SMILES COc1cc(NCc2ccccc2)cc(OC)c1-c1cc(Nc2cnc(cn2)C#N)n[nH]1
Show InChI InChI=1S/C23H21N7O2/c1-31-19-8-16(25-12-15-6-4-3-5-7-15)9-20(32-2)23(19)18-10-21(30-29-18)28-22-14-26-17(11-24)13-27-22/h3-10,13-14,25H,12H2,1-2H3,(H2,27,28,29,30)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401960
PNG
(5-[[5-[5-chloro-2-methoxy-4-(4-piperidyl)phenyl]-1...)
Show SMILES COc1cc(C2CCNCC2)c(Cl)cc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1
Show InChI InChI=1S/C20H20ClN7O/c1-29-18-7-14(12-2-4-23-5-3-12)16(21)6-15(18)17-8-19(28-27-17)26-20-11-24-13(9-22)10-25-20/h6-8,10-12,23H,2-5H2,1H3,(H2,25,26,27,28)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401945
PNG
(5-[[5-[2-isopropoxy-4-(4-piperidyl)phenyl]-1H-pyra...)
Show SMILES CC(C)Oc1cc(ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1)C1CCNCC1
Show InChI InChI=1S/C22H25N7O/c1-14(2)30-20-9-16(15-5-7-24-8-6-15)3-4-18(20)19-10-21(29-28-19)27-22-13-25-17(11-23)12-26-22/h3-4,9-10,12-15,24H,5-8H2,1-2H3,(H2,26,27,28,29)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401919
PNG
(5-[[5-[4-(1-methyl-4-piperidyl)phenyl]-1H-pyrazol-...)
Show SMILES CN1CCC(CC1)c1ccc(cc1)-c1cc(Nc2cnc(cn2)C#N)n[nH]1
Show InChI InChI=1S/C20H21N7/c1-27-8-6-15(7-9-27)14-2-4-16(5-3-14)18-10-19(26-25-18)24-20-13-22-17(11-21)12-23-20/h2-5,10,12-13,15H,6-9H2,1H3,(H2,23,24,25,26)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM402039
PNG
(US10010547, Example 153)
Show SMILES COc1cc(ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1)N(C)CC1CCNCC1
Show InChI InChI=1S/C22H26N8O/c1-30(14-15-5-7-24-8-6-15)17-3-4-18(20(9-17)31-2)19-10-21(29-28-19)27-22-13-25-16(11-23)12-26-22/h3-4,9-10,12-13,15,24H,5-8,14H2,1-2H3,(H2,26,27,28,29)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401943
PNG
(5-[[5-[2-fluoro-4-(4-piperidyl)phenyl]-1H-pyrazol-...)
Show SMILES Fc1cc(ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1)C1CCNCC1
Show InChI InChI=1S/C19H18FN7/c20-16-7-13(12-3-5-22-6-4-12)1-2-15(16)17-8-18(27-26-17)25-19-11-23-14(9-21)10-24-19/h1-2,7-8,10-12,22H,3-6H2,(H2,24,25,26,27)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401961
PNG
(5-[[5-[3-chloro-2-methoxy-4-(1-methyl-4-piperidyl)...)
Show SMILES COc1c(Cl)c(ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1)C1CCN(C)CC1
Show InChI InChI=1S/C21H22ClN7O/c1-29-7-5-13(6-8-29)15-3-4-16(21(30-2)20(15)22)17-9-18(28-27-17)26-19-12-24-14(10-23)11-25-19/h3-4,9,11-13H,5-8H2,1-2H3,(H2,25,26,27,28)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401918
PNG
(N-[5-[2-methoxy-4-(1-methyl-4-piperidyl)phenyl]-1H...)
Show SMILES COc1cc(ccc1-c1cc(Nc2cnc(C)cn2)n[nH]1)C1CCN(C)CC1
Show InChI InChI=1S/C21H26N6O/c1-14-12-23-21(13-22-14)24-20-11-18(25-26-20)17-5-4-16(10-19(17)28-3)15-6-8-27(2)9-7-15/h4-5,10-13,15H,6-9H2,1-3H3,(H2,23,24,25,26)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401962
PNG
(5-[[5-[3-chloro-2-methoxy-4-(4-piperidyl)phenyl]-1...)
Show SMILES COc1c(Cl)c(ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1)C1CCNCC1
Show InChI InChI=1S/C20H20ClN7O/c1-29-20-15(3-2-14(19(20)21)12-4-6-23-7-5-12)16-8-17(28-27-16)26-18-11-24-13(9-22)10-25-18/h2-3,8,10-12,23H,4-7H2,1H3,(H2,25,26,27,28)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401902
PNG
((5-{2-methoxy-4-[(2-morpholin-4-yl-ethylamino)-met...)
Show SMILES COc1cc(CNCCN2CCOCC2)ccc1-c1cc(Nc2cnccn2)n[nH]1
Show InChI InChI=1S/C21H27N7O2/c1-29-19-12-16(14-23-6-7-28-8-10-30-11-9-28)2-3-17(19)18-13-20(27-26-18)25-21-15-22-4-5-24-21/h2-5,12-13,15,23H,6-11,14H2,1H3,(H2,24,25,26,27)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401917
PNG
(6-[[5-[2-methoxy-4-(1-methyl-4-piperidyl)phenyl]-1...)
Show SMILES COc1cc(ccc1-c1cc(Nc2ccc(cn2)C#N)n[nH]1)C1CCN(C)CC1
Show InChI InChI=1S/C22H24N6O/c1-28-9-7-16(8-10-28)17-4-5-18(20(11-17)29-2)19-12-22(27-26-19)25-21-6-3-15(13-23)14-24-21/h3-6,11-12,14,16H,7-10H2,1-2H3,(H2,24,25,26,27)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401922
PNG
(2-fluoro-4-[[5-[2-methoxy-4-(1-methyl-4-piperidyl)...)
Show SMILES COc1cc(ccc1-c1cc(Nc2ccc(C#N)c(F)c2)n[nH]1)C1CCN(C)CC1
Show InChI InChI=1S/C23H24FN5O/c1-29-9-7-15(8-10-29)16-4-6-19(22(11-16)30-2)21-13-23(28-27-21)26-18-5-3-17(14-25)20(24)12-18/h3-6,11-13,15H,7-10H2,1-2H3,(H2,26,27,28)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401942
PNG
(6-[[5-[2-methoxy-4-(4-piperidyl)phenyl]-1H-pyrazol...)
Show SMILES COc1cc(ccc1-c1cc(Nc2ccc(cn2)C#N)n[nH]1)C1CCNCC1
Show InChI InChI=1S/C21H22N6O/c1-28-19-10-16(15-6-8-23-9-7-15)3-4-17(19)18-11-21(27-26-18)25-20-5-2-14(12-22)13-24-20/h2-5,10-11,13,15,23H,6-9H2,1H3,(H2,24,25,26,27)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401941
PNG
(2-fluoro-4-[[5-[2-methoxy-4-(4-piperidyl)phenyl]-1...)
Show SMILES COc1cc(ccc1-c1cc(Nc2ccc(C#N)c(F)c2)n[nH]1)C1CCNCC1
Show InChI InChI=1S/C22H22FN5O/c1-29-21-10-15(14-6-8-25-9-7-14)3-5-18(21)20-12-22(28-27-20)26-17-4-2-16(13-24)19(23)11-17/h2-5,10-12,14,25H,6-9H2,1H3,(H2,26,27,28)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401937
PNG
(5-[[5-[2-methoxy-4-(4-piperidyl)phenyl]-1H-pyrazol...)
Show SMILES COc1cc(ccc1-c1cc(Nc2cnc(cn2)C(O)=O)n[nH]1)C1CCNCC1
Show InChI InChI=1S/C20H22N6O3/c1-29-17-8-13(12-4-6-21-7-5-12)2-3-14(17)15-9-18(26-25-15)24-19-11-22-16(10-23-19)20(27)28/h2-3,8-12,21H,4-7H2,1H3,(H,27,28)(H2,23,24,25,26)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401963
PNG
(US10010547, Example 71 | methyl 5-[[5-[2-methoxy-4...)
Show SMILES COC(=O)c1cnc(Nc2cc([nH]n2)-c2ccc(cc2OC)C2CCNCC2)cn1
Show InChI InChI=1S/C21H24N6O3/c1-29-18-9-14(13-5-7-22-8-6-13)3-4-15(18)16-10-19(27-26-16)25-20-12-23-17(11-24-20)21(28)30-2/h3-4,9-13,22H,5-8H2,1-2H3,(H2,24,25,26,27)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401948
PNG
(5-[[5-[4-(4-piperidyl)phenyl]-1H-pyrazol-3-yl]amin...)
Show SMILES N#Cc1cnc(Nc2cc([nH]n2)-c2ccc(cc2)C2CCNCC2)cn1
Show InChI InChI=1S/C19H19N7/c20-10-16-11-23-19(12-22-16)24-18-9-17(25-26-18)15-3-1-13(2-4-15)14-5-7-21-8-6-14/h1-4,9,11-12,14,21H,5-8H2,(H2,23,24,25,26)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1/2


(Homo sapiens (Human))
BDBM401947
PNG
(N-[5-[2-methoxy-4-(4-piperidyl)phenyl]-1H-pyrazol-...)
Show SMILES COc1cc(ccc1-c1cc(Nc2cnc(C)cn2)n[nH]1)C1CCNCC1
Show InChI InChI=1S/C20H24N6O/c1-13-11-23-20(12-22-13)24-19-10-17(25-26-19)16-4-3-15(9-18(16)27-2)14-5-7-21-8-6-14/h3-4,9-12,14,21H,5-8H2,1-2H3,(H2,23,24,25,26)
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Cascadian Therapeutics, Inc.

US Patent


Assay Description
Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...


US Patent US10010547 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%