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Patent code US10011571

Compile Data Set for Download or QSAR
Found 26 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM402042
PNG
(Preparation of N-(3-(5-chloro-2-(4-fluoro-3-(N-met...)
Show SMILES CN(C(=O)C=C)c1cc(Nc2ncc(Cl)c(NCCCNC(=O)c3ccc(F)cc3)n2)ccc1F
Show InChI InChI=1S/C24H23ClF2N6O2/c1-3-21(34)33(2)20-13-17(9-10-19(20)27)31-24-30-14-18(25)22(32-24)28-11-4-12-29-23(35)15-5-7-16(26)8-6-15/h3,5-10,13-14H,1,4,11-12H2,2H3,(H,29,35)(H2,28,30,31,32)
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n/an/a 11n/an/an/an/an/an/a



SHENZHEN CHIPSCREEN BIOSCIENCES, LTD.

US Patent


Assay Description
Briefly, according to the requirements of different kinase reactions, 0.2 μL test compound (50 μM, dissolved in dimethyl sulfoxide (DMSO)) ...


US Patent US10011571 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM402040
PNG
(Preparation of N-(3-(5-chloro-2-(4-fluoro-3-(N-met...)
Show SMILES CN(C(=O)C=C)c1cc(Nc2ncc(Cl)c(NCCCNC(=O)c3ccc(cc3)C#N)n2)ccc1F
Show InChI InChI=1S/C25H23ClFN7O2/c1-3-22(35)34(2)21-13-18(9-10-20(21)27)32-25-31-15-19(26)23(33-25)29-11-4-12-30-24(36)17-7-5-16(14-28)6-8-17/h3,5-10,13,15H,1,4,11-12H2,2H3,(H,30,36)(H2,29,31,32,33)
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n/an/a 11n/an/an/an/an/an/a



SHENZHEN CHIPSCREEN BIOSCIENCES, LTD.

US Patent


Assay Description
Briefly, according to the requirements of different kinase reactions, 0.2 μL test compound (50 μM, dissolved in dimethyl sulfoxide (DMSO)) ...


US Patent US10011571 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM402041
PNG
(Preparation of N-(3-(5-chloro-2-(4-fluoro-3-(N-met...)
Show SMILES CN(C(=O)C=C)c1cc(Nc2ncc(Cl)c(NCCCNC(=O)c3ccc(cc3)C(F)(F)F)n2)ccc1F
Show InChI InChI=1S/C25H23ClF4N6O2/c1-3-21(37)36(2)20-13-17(9-10-19(20)27)34-24-33-14-18(26)22(35-24)31-11-4-12-32-23(38)15-5-7-16(8-6-15)25(28,29)30/h3,5-10,13-14H,1,4,11-12H2,2H3,(H,32,38)(H2,31,33,34,35)
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n/an/a 21n/an/an/an/an/an/a



SHENZHEN CHIPSCREEN BIOSCIENCES, LTD.

US Patent


Assay Description
Briefly, according to the requirements of different kinase reactions, 0.2 μL test compound (50 μM, dissolved in dimethyl sulfoxide (DMSO)) ...


US Patent US10011571 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM402042
PNG
(Preparation of N-(3-(5-chloro-2-(4-fluoro-3-(N-met...)
Show SMILES CN(C(=O)C=C)c1cc(Nc2ncc(Cl)c(NCCCNC(=O)c3ccc(F)cc3)n2)ccc1F
Show InChI InChI=1S/C24H23ClF2N6O2/c1-3-21(34)33(2)20-13-17(9-10-19(20)27)31-24-30-14-18(25)22(32-24)28-11-4-12-29-23(35)15-5-7-16(26)8-6-15/h3,5-10,13-14H,1,4,11-12H2,2H3,(H,29,35)(H2,28,30,31,32)
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n/an/a 42n/an/an/an/an/an/a



SHENZHEN CHIPSCREEN BIOSCIENCES, LTD.

US Patent


Assay Description
Briefly, according to the requirements of different kinase reactions, 0.2 μL test compound (50 μM, dissolved in dimethyl sulfoxide (DMSO)) ...


US Patent US10011571 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM402040
PNG
(Preparation of N-(3-(5-chloro-2-(4-fluoro-3-(N-met...)
Show SMILES CN(C(=O)C=C)c1cc(Nc2ncc(Cl)c(NCCCNC(=O)c3ccc(cc3)C#N)n2)ccc1F
Show InChI InChI=1S/C25H23ClFN7O2/c1-3-22(35)34(2)21-13-18(9-10-20(21)27)32-25-31-15-19(26)23(33-25)29-11-4-12-30-24(36)17-7-5-16(14-28)6-8-17/h3,5-10,13,15H,1,4,11-12H2,2H3,(H,30,36)(H2,29,31,32,33)
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n/an/a 105n/an/an/an/an/an/a



SHENZHEN CHIPSCREEN BIOSCIENCES, LTD.

US Patent


Assay Description
Briefly, according to the requirements of different kinase reactions, 0.2 μL test compound (50 μM, dissolved in dimethyl sulfoxide (DMSO)) ...


US Patent US10011571 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM402040
PNG
(Preparation of N-(3-(5-chloro-2-(4-fluoro-3-(N-met...)
Show SMILES CN(C(=O)C=C)c1cc(Nc2ncc(Cl)c(NCCCNC(=O)c3ccc(cc3)C#N)n2)ccc1F
Show InChI InChI=1S/C25H23ClFN7O2/c1-3-22(35)34(2)21-13-18(9-10-20(21)27)32-25-31-15-19(26)23(33-25)29-11-4-12-30-24(36)17-7-5-16(14-28)6-8-17/h3,5-10,13,15H,1,4,11-12H2,2H3,(H,30,36)(H2,29,31,32,33)
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n/an/a 107n/an/an/an/an/an/a



SHENZHEN CHIPSCREEN BIOSCIENCES, LTD.

US Patent


Assay Description
Briefly, according to the requirements of different kinase reactions, 0.2 μL test compound (50 μM, dissolved in dimethyl sulfoxide (DMSO)) ...


US Patent US10011571 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM402040
PNG
(Preparation of N-(3-(5-chloro-2-(4-fluoro-3-(N-met...)
Show SMILES CN(C(=O)C=C)c1cc(Nc2ncc(Cl)c(NCCCNC(=O)c3ccc(cc3)C#N)n2)ccc1F
Show InChI InChI=1S/C25H23ClFN7O2/c1-3-22(35)34(2)21-13-18(9-10-20(21)27)32-25-31-15-19(26)23(33-25)29-11-4-12-30-24(36)17-7-5-16(14-28)6-8-17/h3,5-10,13,15H,1,4,11-12H2,2H3,(H,30,36)(H2,29,31,32,33)
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n/an/a 162n/an/an/an/an/an/a



SHENZHEN CHIPSCREEN BIOSCIENCES, LTD.

US Patent


Assay Description
Briefly, according to the requirements of different kinase reactions, 0.2 μL test compound (50 μM, dissolved in dimethyl sulfoxide (DMSO)) ...


US Patent US10011571 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM402042
PNG
(Preparation of N-(3-(5-chloro-2-(4-fluoro-3-(N-met...)
Show SMILES CN(C(=O)C=C)c1cc(Nc2ncc(Cl)c(NCCCNC(=O)c3ccc(F)cc3)n2)ccc1F
Show InChI InChI=1S/C24H23ClF2N6O2/c1-3-21(34)33(2)20-13-17(9-10-19(20)27)31-24-30-14-18(25)22(32-24)28-11-4-12-29-23(35)15-5-7-16(26)8-6-15/h3,5-10,13-14H,1,4,11-12H2,2H3,(H,29,35)(H2,28,30,31,32)
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n/an/a 173n/an/an/an/an/an/a



SHENZHEN CHIPSCREEN BIOSCIENCES, LTD.

US Patent


Assay Description
Briefly, according to the requirements of different kinase reactions, 0.2 μL test compound (50 μM, dissolved in dimethyl sulfoxide (DMSO)) ...


US Patent US10011571 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM402041
PNG
(Preparation of N-(3-(5-chloro-2-(4-fluoro-3-(N-met...)
Show SMILES CN(C(=O)C=C)c1cc(Nc2ncc(Cl)c(NCCCNC(=O)c3ccc(cc3)C(F)(F)F)n2)ccc1F
Show InChI InChI=1S/C25H23ClF4N6O2/c1-3-21(37)36(2)20-13-17(9-10-19(20)27)34-24-33-14-18(26)22(35-24)31-11-4-12-32-23(38)15-5-7-16(8-6-15)25(28,29)30/h3,5-10,13-14H,1,4,11-12H2,2H3,(H,32,38)(H2,31,33,34,35)
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n/an/a 279n/an/an/an/an/an/a



SHENZHEN CHIPSCREEN BIOSCIENCES, LTD.

US Patent


Assay Description
Briefly, according to the requirements of different kinase reactions, 0.2 μL test compound (50 μM, dissolved in dimethyl sulfoxide (DMSO)) ...


US Patent US10011571 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Blk


(Homo sapiens (Human))
BDBM402040
PNG
(Preparation of N-(3-(5-chloro-2-(4-fluoro-3-(N-met...)
Show SMILES CN(C(=O)C=C)c1cc(Nc2ncc(Cl)c(NCCCNC(=O)c3ccc(cc3)C#N)n2)ccc1F
Show InChI InChI=1S/C25H23ClFN7O2/c1-3-22(35)34(2)21-13-18(9-10-20(21)27)32-25-31-15-19(26)23(33-25)29-11-4-12-30-24(36)17-7-5-16(14-28)6-8-17/h3,5-10,13,15H,1,4,11-12H2,2H3,(H,30,36)(H2,29,31,32,33)
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n/an/a 286n/an/an/an/an/an/a



SHENZHEN CHIPSCREEN BIOSCIENCES, LTD.

US Patent


Assay Description
Briefly, according to the requirements of different kinase reactions, 0.2 μL test compound (50 μM, dissolved in dimethyl sulfoxide (DMSO)) ...


US Patent US10011571 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))
BDBM402040
PNG
(Preparation of N-(3-(5-chloro-2-(4-fluoro-3-(N-met...)
Show SMILES CN(C(=O)C=C)c1cc(Nc2ncc(Cl)c(NCCCNC(=O)c3ccc(cc3)C#N)n2)ccc1F
Show InChI InChI=1S/C25H23ClFN7O2/c1-3-22(35)34(2)21-13-18(9-10-20(21)27)32-25-31-15-19(26)23(33-25)29-11-4-12-30-24(36)17-7-5-16(14-28)6-8-17/h3,5-10,13,15H,1,4,11-12H2,2H3,(H,30,36)(H2,29,31,32,33)
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n/an/a 319n/an/an/an/an/an/a



SHENZHEN CHIPSCREEN BIOSCIENCES, LTD.

US Patent


Assay Description
Briefly, according to the requirements of different kinase reactions, 0.2 μL test compound (50 μM, dissolved in dimethyl sulfoxide (DMSO)) ...


US Patent US10011571 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM402042
PNG
(Preparation of N-(3-(5-chloro-2-(4-fluoro-3-(N-met...)
Show SMILES CN(C(=O)C=C)c1cc(Nc2ncc(Cl)c(NCCCNC(=O)c3ccc(F)cc3)n2)ccc1F
Show InChI InChI=1S/C24H23ClF2N6O2/c1-3-21(34)33(2)20-13-17(9-10-19(20)27)31-24-30-14-18(25)22(32-24)28-11-4-12-29-23(35)15-5-7-16(26)8-6-15/h3,5-10,13-14H,1,4,11-12H2,2H3,(H,29,35)(H2,28,30,31,32)
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n/an/a 664n/an/an/an/an/an/a



SHENZHEN CHIPSCREEN BIOSCIENCES, LTD.

US Patent


Assay Description
Briefly, according to the requirements of different kinase reactions, 0.2 μL test compound (50 μM, dissolved in dimethyl sulfoxide (DMSO)) ...


US Patent US10011571 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM402040
PNG
(Preparation of N-(3-(5-chloro-2-(4-fluoro-3-(N-met...)
Show SMILES CN(C(=O)C=C)c1cc(Nc2ncc(Cl)c(NCCCNC(=O)c3ccc(cc3)C#N)n2)ccc1F
Show InChI InChI=1S/C25H23ClFN7O2/c1-3-22(35)34(2)21-13-18(9-10-20(21)27)32-25-31-15-19(26)23(33-25)29-11-4-12-30-24(36)17-7-5-16(14-28)6-8-17/h3,5-10,13,15H,1,4,11-12H2,2H3,(H,30,36)(H2,29,31,32,33)
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n/an/a 698n/an/an/an/an/an/a



SHENZHEN CHIPSCREEN BIOSCIENCES, LTD.

US Patent


Assay Description
Briefly, according to the requirements of different kinase reactions, 0.2 μL test compound (50 μM, dissolved in dimethyl sulfoxide (DMSO)) ...


US Patent US10011571 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Blk


(Homo sapiens (Human))
BDBM402042
PNG
(Preparation of N-(3-(5-chloro-2-(4-fluoro-3-(N-met...)
Show SMILES CN(C(=O)C=C)c1cc(Nc2ncc(Cl)c(NCCCNC(=O)c3ccc(F)cc3)n2)ccc1F
Show InChI InChI=1S/C24H23ClF2N6O2/c1-3-21(34)33(2)20-13-17(9-10-19(20)27)31-24-30-14-18(25)22(32-24)28-11-4-12-29-23(35)15-5-7-16(26)8-6-15/h3,5-10,13-14H,1,4,11-12H2,2H3,(H,29,35)(H2,28,30,31,32)
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SHENZHEN CHIPSCREEN BIOSCIENCES, LTD.

US Patent


Assay Description
Briefly, according to the requirements of different kinase reactions, 0.2 μL test compound (50 μM, dissolved in dimethyl sulfoxide (DMSO)) ...


US Patent US10011571 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM402042
PNG
(Preparation of N-(3-(5-chloro-2-(4-fluoro-3-(N-met...)
Show SMILES CN(C(=O)C=C)c1cc(Nc2ncc(Cl)c(NCCCNC(=O)c3ccc(F)cc3)n2)ccc1F
Show InChI InChI=1S/C24H23ClF2N6O2/c1-3-21(34)33(2)20-13-17(9-10-19(20)27)31-24-30-14-18(25)22(32-24)28-11-4-12-29-23(35)15-5-7-16(26)8-6-15/h3,5-10,13-14H,1,4,11-12H2,2H3,(H,29,35)(H2,28,30,31,32)
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n/an/a 1.23E+3n/an/an/an/an/an/a



SHENZHEN CHIPSCREEN BIOSCIENCES, LTD.

US Patent


Assay Description
Briefly, according to the requirements of different kinase reactions, 0.2 μL test compound (50 μM, dissolved in dimethyl sulfoxide (DMSO)) ...


US Patent US10011571 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM402040
PNG
(Preparation of N-(3-(5-chloro-2-(4-fluoro-3-(N-met...)
Show SMILES CN(C(=O)C=C)c1cc(Nc2ncc(Cl)c(NCCCNC(=O)c3ccc(cc3)C#N)n2)ccc1F
Show InChI InChI=1S/C25H23ClFN7O2/c1-3-22(35)34(2)21-13-18(9-10-20(21)27)32-25-31-15-19(26)23(33-25)29-11-4-12-30-24(36)17-7-5-16(14-28)6-8-17/h3,5-10,13,15H,1,4,11-12H2,2H3,(H,30,36)(H2,29,31,32,33)
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n/an/a 1.40E+3n/an/an/an/an/an/a



SHENZHEN CHIPSCREEN BIOSCIENCES, LTD.

US Patent


Assay Description
Briefly, according to the requirements of different kinase reactions, 0.2 μL test compound (50 μM, dissolved in dimethyl sulfoxide (DMSO)) ...


US Patent US10011571 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Blk


(Homo sapiens (Human))
BDBM402041
PNG
(Preparation of N-(3-(5-chloro-2-(4-fluoro-3-(N-met...)
Show SMILES CN(C(=O)C=C)c1cc(Nc2ncc(Cl)c(NCCCNC(=O)c3ccc(cc3)C(F)(F)F)n2)ccc1F
Show InChI InChI=1S/C25H23ClF4N6O2/c1-3-21(37)36(2)20-13-17(9-10-19(20)27)34-24-33-14-18(26)22(35-24)31-11-4-12-32-23(38)15-5-7-16(8-6-15)25(28,29)30/h3,5-10,13-14H,1,4,11-12H2,2H3,(H,32,38)(H2,31,33,34,35)
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SHENZHEN CHIPSCREEN BIOSCIENCES, LTD.

US Patent


Assay Description
Briefly, according to the requirements of different kinase reactions, 0.2 μL test compound (50 μM, dissolved in dimethyl sulfoxide (DMSO)) ...


US Patent US10011571 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM402042
PNG
(Preparation of N-(3-(5-chloro-2-(4-fluoro-3-(N-met...)
Show SMILES CN(C(=O)C=C)c1cc(Nc2ncc(Cl)c(NCCCNC(=O)c3ccc(F)cc3)n2)ccc1F
Show InChI InChI=1S/C24H23ClF2N6O2/c1-3-21(34)33(2)20-13-17(9-10-19(20)27)31-24-30-14-18(25)22(32-24)28-11-4-12-29-23(35)15-5-7-16(26)8-6-15/h3,5-10,13-14H,1,4,11-12H2,2H3,(H,29,35)(H2,28,30,31,32)
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n/an/a 1.92E+3n/an/an/an/an/an/a



SHENZHEN CHIPSCREEN BIOSCIENCES, LTD.

US Patent


Assay Description
Briefly, according to the requirements of different kinase reactions, 0.2 μL test compound (50 μM, dissolved in dimethyl sulfoxide (DMSO)) ...


US Patent US10011571 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM402041
PNG
(Preparation of N-(3-(5-chloro-2-(4-fluoro-3-(N-met...)
Show SMILES CN(C(=O)C=C)c1cc(Nc2ncc(Cl)c(NCCCNC(=O)c3ccc(cc3)C(F)(F)F)n2)ccc1F
Show InChI InChI=1S/C25H23ClF4N6O2/c1-3-21(37)36(2)20-13-17(9-10-19(20)27)34-24-33-14-18(26)22(35-24)31-11-4-12-32-23(38)15-5-7-16(8-6-15)25(28,29)30/h3,5-10,13-14H,1,4,11-12H2,2H3,(H,32,38)(H2,31,33,34,35)
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n/an/a>1.00E+4n/an/an/an/an/an/a



SHENZHEN CHIPSCREEN BIOSCIENCES, LTD.

US Patent


Assay Description
Briefly, according to the requirements of different kinase reactions, 0.2 μL test compound (50 μM, dissolved in dimethyl sulfoxide (DMSO)) ...


US Patent US10011571 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM402041
PNG
(Preparation of N-(3-(5-chloro-2-(4-fluoro-3-(N-met...)
Show SMILES CN(C(=O)C=C)c1cc(Nc2ncc(Cl)c(NCCCNC(=O)c3ccc(cc3)C(F)(F)F)n2)ccc1F
Show InChI InChI=1S/C25H23ClF4N6O2/c1-3-21(37)36(2)20-13-17(9-10-19(20)27)34-24-33-14-18(26)22(35-24)31-11-4-12-32-23(38)15-5-7-16(8-6-15)25(28,29)30/h3,5-10,13-14H,1,4,11-12H2,2H3,(H,32,38)(H2,31,33,34,35)
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US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



SHENZHEN CHIPSCREEN BIOSCIENCES, LTD.

US Patent


Assay Description
Briefly, according to the requirements of different kinase reactions, 0.2 μL test compound (50 μM, dissolved in dimethyl sulfoxide (DMSO)) ...


US Patent US10011571 (2018)

More data for this
Ligand-Target Pair
JAK2/TYK2


(Homo sapiens (Human))
BDBM402041
PNG
(Preparation of N-(3-(5-chloro-2-(4-fluoro-3-(N-met...)
Show SMILES CN(C(=O)C=C)c1cc(Nc2ncc(Cl)c(NCCCNC(=O)c3ccc(cc3)C(F)(F)F)n2)ccc1F
Show InChI InChI=1S/C25H23ClF4N6O2/c1-3-21(37)36(2)20-13-17(9-10-19(20)27)34-24-33-14-18(26)22(35-24)31-11-4-12-32-23(38)15-5-7-16(8-6-15)25(28,29)30/h3,5-10,13-14H,1,4,11-12H2,2H3,(H,32,38)(H2,31,33,34,35)
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US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



SHENZHEN CHIPSCREEN BIOSCIENCES, LTD.

US Patent


Assay Description
Briefly, according to the requirements of different kinase reactions, 0.2 μL test compound (50 μM, dissolved in dimethyl sulfoxide (DMSO)) ...


US Patent US10011571 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM402041
PNG
(Preparation of N-(3-(5-chloro-2-(4-fluoro-3-(N-met...)
Show SMILES CN(C(=O)C=C)c1cc(Nc2ncc(Cl)c(NCCCNC(=O)c3ccc(cc3)C(F)(F)F)n2)ccc1F
Show InChI InChI=1S/C25H23ClF4N6O2/c1-3-21(37)36(2)20-13-17(9-10-19(20)27)34-24-33-14-18(26)22(35-24)31-11-4-12-32-23(38)15-5-7-16(8-6-15)25(28,29)30/h3,5-10,13-14H,1,4,11-12H2,2H3,(H,32,38)(H2,31,33,34,35)
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US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



SHENZHEN CHIPSCREEN BIOSCIENCES, LTD.

US Patent


Assay Description
Briefly, according to the requirements of different kinase reactions, 0.2 μL test compound (50 μM, dissolved in dimethyl sulfoxide (DMSO)) ...


US Patent US10011571 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))
BDBM402041
PNG
(Preparation of N-(3-(5-chloro-2-(4-fluoro-3-(N-met...)
Show SMILES CN(C(=O)C=C)c1cc(Nc2ncc(Cl)c(NCCCNC(=O)c3ccc(cc3)C(F)(F)F)n2)ccc1F
Show InChI InChI=1S/C25H23ClF4N6O2/c1-3-21(37)36(2)20-13-17(9-10-19(20)27)34-24-33-14-18(26)22(35-24)31-11-4-12-32-23(38)15-5-7-16(8-6-15)25(28,29)30/h3,5-10,13-14H,1,4,11-12H2,2H3,(H,32,38)(H2,31,33,34,35)
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n/an/a>1.00E+4n/an/an/an/an/an/a



SHENZHEN CHIPSCREEN BIOSCIENCES, LTD.

US Patent


Assay Description
Briefly, according to the requirements of different kinase reactions, 0.2 μL test compound (50 μM, dissolved in dimethyl sulfoxide (DMSO)) ...


US Patent US10011571 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM402041
PNG
(Preparation of N-(3-(5-chloro-2-(4-fluoro-3-(N-met...)
Show SMILES CN(C(=O)C=C)c1cc(Nc2ncc(Cl)c(NCCCNC(=O)c3ccc(cc3)C(F)(F)F)n2)ccc1F
Show InChI InChI=1S/C25H23ClF4N6O2/c1-3-21(37)36(2)20-13-17(9-10-19(20)27)34-24-33-14-18(26)22(35-24)31-11-4-12-32-23(38)15-5-7-16(8-6-15)25(28,29)30/h3,5-10,13-14H,1,4,11-12H2,2H3,(H,32,38)(H2,31,33,34,35)
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n/an/a>1.00E+4n/an/an/an/an/an/a



SHENZHEN CHIPSCREEN BIOSCIENCES, LTD.

US Patent


Assay Description
Briefly, according to the requirements of different kinase reactions, 0.2 μL test compound (50 μM, dissolved in dimethyl sulfoxide (DMSO)) ...


US Patent US10011571 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))
BDBM402042
PNG
(Preparation of N-(3-(5-chloro-2-(4-fluoro-3-(N-met...)
Show SMILES CN(C(=O)C=C)c1cc(Nc2ncc(Cl)c(NCCCNC(=O)c3ccc(F)cc3)n2)ccc1F
Show InChI InChI=1S/C24H23ClF2N6O2/c1-3-21(34)33(2)20-13-17(9-10-19(20)27)31-24-30-14-18(25)22(32-24)28-11-4-12-29-23(35)15-5-7-16(26)8-6-15/h3,5-10,13-14H,1,4,11-12H2,2H3,(H,29,35)(H2,28,30,31,32)
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n/an/a>1.00E+4n/an/an/an/an/an/a



SHENZHEN CHIPSCREEN BIOSCIENCES, LTD.

US Patent


Assay Description
Briefly, according to the requirements of different kinase reactions, 0.2 μL test compound (50 μM, dissolved in dimethyl sulfoxide (DMSO)) ...


US Patent US10011571 (2018)

More data for this
Ligand-Target Pair
JAK2/TYK2


(Homo sapiens (Human))
BDBM402040
PNG
(Preparation of N-(3-(5-chloro-2-(4-fluoro-3-(N-met...)
Show SMILES CN(C(=O)C=C)c1cc(Nc2ncc(Cl)c(NCCCNC(=O)c3ccc(cc3)C#N)n2)ccc1F
Show InChI InChI=1S/C25H23ClFN7O2/c1-3-22(35)34(2)21-13-18(9-10-20(21)27)32-25-31-15-19(26)23(33-25)29-11-4-12-30-24(36)17-7-5-16(14-28)6-8-17/h3,5-10,13,15H,1,4,11-12H2,2H3,(H,30,36)(H2,29,31,32,33)
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n/an/a>1.00E+4n/an/an/an/an/an/a



SHENZHEN CHIPSCREEN BIOSCIENCES, LTD.

US Patent


Assay Description
Briefly, according to the requirements of different kinase reactions, 0.2 μL test compound (50 μM, dissolved in dimethyl sulfoxide (DMSO)) ...


US Patent US10011571 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%