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Patent code US10011593

Compile Data Set for Download or QSAR
Found 16 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM308058
PNG
(US10011593, Ex. 9 | US9650366, 9)
Show SMILES Cc1ccoc1C(=O)Nc1cccc(c1)C#Cc1cncc(c1)-c1nnn(CCCO)n1
Show InChI InChI=1S/C23H20N6O3/c1-16-8-11-32-21(16)23(31)25-20-5-2-4-17(13-20)6-7-18-12-19(15-24-14-18)22-26-28-29(27-22)9-3-10-30/h2,4-5,8,11-15,30H,3,9-10H2,1H3,(H,25,31)
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n/an/a 5n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
VEGFR2: Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:...


US Patent US10011593 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM308059
PNG
(US10011593, Ex. 10 | US9650366, 10)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(c1)C#Cc1cncc(c1)-c1nnn(CCCO)n1
Show InChI InChI=1S/C25H22N6O2/c1-18-5-2-7-21(13-18)25(33)27-23-8-3-6-19(15-23)9-10-20-14-22(17-26-16-20)24-28-30-31(29-24)11-4-12-32/h2-3,5-8,13-17,32H,4,11-12H2,1H3,(H,27,33)
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n/an/a 7n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
VEGFR2: Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:...


US Patent US10011593 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM308061
PNG
(US10011593, Ex. 12 | US9650366, 12)
Show SMILES OCCCn1nnc(n1)-c1cncc(c1)C#Cc1ccc(NC(=O)Nc2cc(ccc2F)C(F)(F)F)cc1
Show InChI InChI=1S/C25H19F4N7O2/c26-21-9-6-19(25(27,28)29)13-22(21)32-24(38)31-20-7-4-16(5-8-20)2-3-17-12-18(15-30-14-17)23-33-35-36(34-23)10-1-11-37/h4-9,12-15,37H,1,10-11H2,(H2,31,32,38)
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n/an/a 8n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
VEGFR2: Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:...


US Patent US10011593 (2018)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta)


(Homo sapiens (Human))
BDBM308058
PNG
(US10011593, Ex. 9 | US9650366, 9)
Show SMILES Cc1ccoc1C(=O)Nc1cccc(c1)C#Cc1cncc(c1)-c1nnn(CCCO)n1
Show InChI InChI=1S/C23H20N6O3/c1-16-8-11-32-21(16)23(31)25-20-5-2-4-17(13-20)6-7-18-12-19(15-24-14-18)22-26-28-29(27-22)9-3-10-30/h2,4-5,8,11-15,30H,3,9-10H2,1H3,(H,25,31)
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n/an/a 21n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
PDGFRβ: Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu...


US Patent US10011593 (2018)

More data for this
Ligand-Target Pair
Interferon-induced, double-stranded RNA-activated protein kinase


(Homo sapiens (Human))
BDBM308051
PNG
(US10011593, Ex. 3 | US9650366, 3)
Show SMILES Nc1ncc(cc1-c1cc2cc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)ccc2s1)-c1nnn(CCCO)n1
Show InChI InChI=1S/C25H20ClF3N8O2S/c26-19-4-2-16(11-18(19)25(27,28)29)33-24(39)32-15-3-5-20-13(8-15)10-21(40-20)17-9-14(12-31-22(17)30)23-34-36-37(35-23)6-1-7-38/h2-5,8-12,38H,1,6-7H2,(H2,30,31)(H2,32,33,39)
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n/an/a 39n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
PKR: Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, p...


US Patent US10011593 (2018)

More data for this
Ligand-Target Pair
Interferon-induced, double-stranded RNA-activated protein kinase


(Homo sapiens (Human))
BDBM308056
PNG
(US10011593, Ex. 6 | US9650366, 6)
Show SMILES Nc1ncc(cc1-c1cc2cc(NC(=O)Nc3cc(cc(c3)C(F)(F)F)C(F)(F)F)ccc2s1)-c1nnn(CCCO)n1
Show InChI InChI=1S/C26H20F6N8O2S/c27-25(28,29)15-9-16(26(30,31)32)11-18(10-15)36-24(42)35-17-2-3-20-13(6-17)8-21(43-20)19-7-14(12-34-22(19)33)23-37-39-40(38-23)4-1-5-41/h2-3,6-12,41H,1,4-5H2,(H2,33,34)(H2,35,36,42)
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n/an/a 66n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
PKR: Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, p...


US Patent US10011593 (2018)

More data for this
Ligand-Target Pair
Interferon-induced, double-stranded RNA-activated protein kinase


(Homo sapiens (Human))
BDBM308055
PNG
(US10011593, Ex. 5 | US9650366, 5)
Show SMILES Nc1ncc(cc1-c1cc2cc(NC(=O)Nc3cc(F)cc(c3)C(F)(F)F)ccc2s1)-c1nnn(CCCO)n1
Show InChI InChI=1S/C25H20F4N8O2S/c26-16-9-15(25(27,28)29)10-18(11-16)33-24(39)32-17-2-3-20-13(6-17)8-21(40-20)19-7-14(12-31-22(19)30)23-34-36-37(35-23)4-1-5-38/h2-3,6-12,38H,1,4-5H2,(H2,30,31)(H2,32,33,39)
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n/an/a 76n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
PKR: Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, p...


US Patent US10011593 (2018)

More data for this
Ligand-Target Pair
Interferon-induced, double-stranded RNA-activated protein kinase


(Homo sapiens (Human))
BDBM308057
PNG
(US10011593, Ex. 8 | US9650366, 8)
Show SMILES Nc1ncc(cc1-c1cc2cc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)ccc2s1)-c1nnn(CCO)n1
Show InChI InChI=1S/C24H18ClF3N8O2S/c25-18-3-1-15(10-17(18)24(26,27)28)32-23(38)31-14-2-4-19-12(7-14)9-20(39-19)16-8-13(11-30-21(16)29)22-33-35-36(34-22)5-6-37/h1-4,7-11,37H,5-6H2,(H2,29,30)(H2,31,32,38)
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ALLERGAN, INC.

US Patent


Assay Description
PKR: Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, p...


US Patent US10011593 (2018)

More data for this
Ligand-Target Pair
Interferon-induced, double-stranded RNA-activated protein kinase


(Homo sapiens (Human))
BDBM308054
PNG
(US10011593, Ex. 4 | US9650366, 4)
Show SMILES Nc1ncc(cc1-c1cc2cc(NC(=O)Nc3ccc(F)c(c3)C(F)(F)F)ccc2s1)-c1nnn(CCCO)n1
Show InChI InChI=1S/C25H20F4N8O2S/c26-19-4-2-16(11-18(19)25(27,28)29)33-24(39)32-15-3-5-20-13(8-15)10-21(40-20)17-9-14(12-31-22(17)30)23-34-36-37(35-23)6-1-7-38/h2-5,8-12,38H,1,6-7H2,(H2,30,31)(H2,32,33,39)
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n/an/a 99n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
PKR: Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, p...


US Patent US10011593 (2018)

More data for this
Ligand-Target Pair
Interferon-induced, double-stranded RNA-activated protein kinase


(Homo sapiens (Human))
BDBM308050
PNG
(US10011593, Ex. 2 | US9650366, 2)
Show SMILES Nc1ncc(cc1-c1cc2cc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)ccc2s1)-c1nn[nH]n1
Show InChI InChI=1S/C22H14ClF3N8OS/c23-16-3-1-13(8-15(16)22(24,25)26)30-21(35)29-12-2-4-17-10(5-12)7-18(36-17)14-6-11(9-28-19(14)27)20-31-33-34-32-20/h1-9H,(H2,27,28)(H2,29,30,35)(H,31,32,33,34)
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ALLERGAN, INC.

US Patent


Assay Description
PKR: Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, p...


US Patent US10011593 (2018)

More data for this
Ligand-Target Pair
Interferon-induced, double-stranded RNA-activated protein kinase


(Homo sapiens (Human))
BDBM308060
PNG
(US10011593, Ex. 11 | US9650366, 11)
Show SMILES Nc1ncc(cc1C#Cc1cccc(NC(=O)Nc2ccc(Cl)c(c2)C(F)(F)F)c1)-c1nnn(CCCO)n1
Show InChI InChI=1S/C25H20ClF3N8O2/c26-21-8-7-19(13-20(21)25(27,28)29)33-24(39)32-18-4-1-3-15(11-18)5-6-16-12-17(14-31-22(16)30)23-34-36-37(35-23)9-2-10-38/h1,3-4,7-8,11-14,38H,2,9-10H2,(H2,30,31)(H2,32,33,39)
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n/an/a 158n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
PKR: Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, p...


US Patent US10011593 (2018)

More data for this
Ligand-Target Pair
Interferon-induced, double-stranded RNA-activated protein kinase


(Homo sapiens (Human))
BDBM308063
PNG
(US10011593, Ex. 14 | US9650366, 14)
Show SMILES Nc1ncc(cc1-c1cc2cc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)ccc2s1)-c1cnccn1
Show InChI InChI=1S/C25H16ClF3N6OS/c26-19-3-1-16(10-18(19)25(27,28)29)35-24(36)34-15-2-4-21-13(7-15)9-22(37-21)17-8-14(11-33-23(17)30)20-12-31-5-6-32-20/h1-12H,(H2,30,33)(H2,34,35,36)
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n/an/a 301n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
PKR: Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, p...


US Patent US10011593 (2018)

More data for this
Ligand-Target Pair
Interferon-induced, double-stranded RNA-activated protein kinase


(Homo sapiens (Human))
BDBM308062
PNG
(US10011593, Ex. 13 | US9650366, 13)
Show SMILES Nc1ncc(cc1-c1cc2cc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)ccc2s1)-c1ncccn1
Show InChI InChI=1S/C25H16ClF3N6OS/c26-19-4-2-16(11-18(19)25(27,28)29)35-24(36)34-15-3-5-20-13(8-15)10-21(37-20)17-9-14(12-33-22(17)30)23-31-6-1-7-32-23/h1-12H,(H2,30,33)(H2,34,35,36)
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ALLERGAN, INC.

US Patent


Assay Description
PKR: Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, p...


US Patent US10011593 (2018)

More data for this
Ligand-Target Pair
Interferon-induced, double-stranded RNA-activated protein kinase


(Homo sapiens (Human))
BDBM308049
PNG
(US10011593, Ex. 1 | US9650366, 1)
Show SMILES FC(F)(F)c1cc(NC(=O)Nc2ccc3sc(cc3c2)-c2cncc(c2)-c2nn[nH]n2)ccc1Cl
Show InChI InChI=1S/C22H13ClF3N7OS/c23-17-3-1-15(8-16(17)22(24,25)26)29-21(34)28-14-2-4-18-11(6-14)7-19(35-18)12-5-13(10-27-9-12)20-30-32-33-31-20/h1-10H,(H2,28,29,34)(H,30,31,32,33)
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ALLERGAN, INC.

US Patent


Assay Description
PKR: Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, p...


US Patent US10011593 (2018)

More data for this
Ligand-Target Pair
Interferon-induced, double-stranded RNA-activated protein kinase


(Homo sapiens (Human))
BDBM308058
PNG
(US10011593, Ex. 9 | US9650366, 9)
Show SMILES Cc1ccoc1C(=O)Nc1cccc(c1)C#Cc1cncc(c1)-c1nnn(CCCO)n1
Show InChI InChI=1S/C23H20N6O3/c1-16-8-11-32-21(16)23(31)25-20-5-2-4-17(13-20)6-7-18-12-19(15-24-14-18)22-26-28-29(27-22)9-3-10-30/h2,4-5,8,11-15,30H,3,9-10H2,1H3,(H,25,31)
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n/an/a>1.00E+4n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
PKR: Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, p...


US Patent US10011593 (2018)

More data for this
Ligand-Target Pair
Interferon-induced, double-stranded RNA-activated protein kinase


(Homo sapiens (Human))
BDBM308061
PNG
(US10011593, Ex. 12 | US9650366, 12)
Show SMILES OCCCn1nnc(n1)-c1cncc(c1)C#Cc1ccc(NC(=O)Nc2cc(ccc2F)C(F)(F)F)cc1
Show InChI InChI=1S/C25H19F4N7O2/c26-21-9-6-19(25(27,28)29)13-22(21)32-24(38)31-20-7-4-16(5-8-20)2-3-17-12-18(15-30-14-17)23-33-35-36(34-23)10-1-11-37/h4-9,12-15,37H,1,10-11H2,(H2,31,32,38)
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n/an/a>1.00E+4n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
PKR: Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, p...


US Patent US10011593 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%