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Patent code US10011604

Compile Data Set for Download or QSAR
Found 60 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200576
PNG
(US10011604, 4 | US9227975, 4 | US9795611, 4)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C24H22F2N6O3S/c1-36(34,35)30-17-7-4-15(5-8-17)24(33)28-23-14-27-21-10-11-22(29-32(21)23)31-12-2-3-20(31)18-13-16(25)6-9-19(18)26/h4-11,13-14,20,30H,2-3,12H2,1H3,(H,28,33)/t20-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.10n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200614
PNG
(US10011604, 40 | US9227975, 40 | US9796723, 40)
Show SMILES O[C@@H]1CN(C[C@H]1O)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C21H22F2N6O3/c22-12-3-4-14(23)13(8-12)15-2-1-7-28(15)19-6-5-18-24-9-20(29(18)26-19)25-21(32)27-10-16(30)17(31)11-27/h3-6,8-9,15-17,30-31H,1-2,7,10-11H2,(H,25,32)/t15-,16-,17-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.20n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200633
PNG
(US10011604, 57 | US9227975, 57 | US9796723, 57)
Show SMILES Cn1nc(ccc1=O)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C22H19F2N7O2/c1-29-21(32)9-6-16(27-29)22(33)26-20-12-25-18-7-8-19(28-31(18)20)30-10-2-3-17(30)14-11-13(23)4-5-15(14)24/h4-9,11-12,17H,2-3,10H2,1H3,(H,26,33)/t17-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.30n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200582
PNG
(US10011604, 10 | US9227975, 10 | US9795611, 10)
Show SMILES O[C@H]1CCN(C1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C21H22F2N6O2/c22-13-3-4-16(23)15(10-13)17-2-1-8-28(17)19-6-5-18-24-11-20(29(18)26-19)25-21(31)27-9-7-14(30)12-27/h3-6,10-11,14,17,30H,1-2,7-9,12H2,(H,25,31)/t14-,17+/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.80n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200575
PNG
(US10011604, 3 | US9227975, 3 | US9795611, 3)
Show SMILES CC(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C18H17F2N5O/c1-11(26)22-18-10-21-16-6-7-17(23-25(16)18)24-8-2-3-15(24)13-9-12(19)4-5-14(13)20/h4-7,9-10,15H,2-3,8H2,1H3,(H,22,26)/t15-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.40n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200604
PNG
(US10011604, 30 | US9227975, 30 | US9796723, 30)
Show SMILES COc1ccc(NC(=O)Nc2cnc3ccc(nn23)N2CCC[C@@H]2c2cc(F)ccc2F)cc1
Show InChI InChI=1/C24H22F2N6O2/c1-34-17-7-5-16(6-8-17)28-24(33)29-23-14-27-21-10-11-22(30-32(21)23)31-12-2-3-20(31)18-13-15(25)4-9-19(18)26/h4-11,13-14,20H,2-3,12H2,1H3,(H2,28,29,33)/t20-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200599
PNG
(US10011604, 26 | US9227975, 26 | US9796723, 26)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccc2ncc(NC(=O)N3CCCCC3)n2n1
Show InChI InChI=1/C22H24F2N6O/c23-15-6-7-17(24)16(13-15)18-5-4-12-29(18)20-9-8-19-25-14-21(30(19)27-20)26-22(31)28-10-2-1-3-11-28/h6-9,13-14,18H,1-5,10-12H2,(H,26,31)/t18-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 7.10n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200622
PNG
(US10011604, 48 | US9227975, 48 | US9796723, 48)
Show SMILES CC(C)(C)OC(=O)N1CCN(CC1(C)C)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C28H35F2N7O3/c1-27(2,3)40-26(39)36-14-13-34(17-28(36,4)5)25(38)32-24-16-31-22-10-11-23(33-37(22)24)35-12-6-7-21(35)19-15-18(29)8-9-20(19)30/h8-11,15-16,21H,6-7,12-14,17H2,1-5H3,(H,32,38)/t21-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 8.30n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200573
PNG
(US10011604, 1 | US9227975, 1 | US9795611, 1)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccc2ncc(NC(=O)Nc3ccccc3)n2n1
Show InChI InChI=1/C23H20F2N6O/c24-15-8-9-18(25)17(13-15)19-7-4-12-30(19)21-11-10-20-26-14-22(31(20)29-21)28-23(32)27-16-5-2-1-3-6-16/h1-3,5-6,8-11,13-14,19H,4,7,12H2,(H2,27,28,32)/t19-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 8.30n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200629
PNG
(US10011604, 54 | US9227975, 54 | US9796723, 54)
Show SMILES CC1(O)CN(C1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C21H22F2N6O2/c1-21(31)11-27(12-21)20(30)25-19-10-24-17-6-7-18(26-29(17)19)28-8-2-3-16(28)14-9-13(22)4-5-15(14)23/h4-7,9-10,16,31H,2-3,8,11-12H2,1H3,(H,25,30)/t16-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 8.90n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200586
PNG
(US10011604, 13 | US9227975, 13 | US9795611, 13)
Show SMILES OC1CN(C1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C20H20F2N6O2/c21-12-3-4-15(22)14(8-12)16-2-1-7-27(16)18-6-5-17-23-9-19(28(17)25-18)24-20(30)26-10-13(29)11-26/h3-6,8-9,13,16,29H,1-2,7,10-11H2,(H,24,30)/t16-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 9.40n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200603
PNG
(US10011604, 29 | US9227975, 29 | US9796723, 29)
Show SMILES CC(C)(C)NC(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C21H24F2N6O/c1-21(2,3)26-20(30)25-19-12-24-17-8-9-18(27-29(17)19)28-10-4-5-16(28)14-11-13(22)6-7-15(14)23/h6-9,11-12,16H,4-5,10H2,1-3H3,(H2,25,26,30)/t16-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 9.80n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200595
PNG
(US10011604, 22 | US9227975, 22 | US9795611, 22)
Show SMILES Fc1ccc(NC(=O)Nc2cnc3ccc(nn23)N2CCC[C@@H]2c2cc(F)ccc2F)cc1
Show InChI InChI=1/C23H19F3N6O/c24-14-3-6-16(7-4-14)28-23(33)29-22-13-27-20-9-10-21(30-32(20)22)31-11-1-2-19(31)17-12-15(25)5-8-18(17)26/h3-10,12-13,19H,1-2,11H2,(H2,28,29,33)/t19-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 10n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200632
PNG
(US10011604, 56 | US9227975, 56 | US9796723, 56)
Show SMILES Cn1cc(ccc1=O)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C23H20F2N6O2/c1-29-13-14(4-9-22(29)32)23(33)27-21-12-26-19-7-8-20(28-31(19)21)30-10-2-3-18(30)16-11-15(24)5-6-17(16)25/h4-9,11-13,18H,2-3,10H2,1H3,(H,27,33)/t18-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 10.2n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200621
PNG
(US10011604, 47 | US9227975, 47 | US9796723, 47)
Show SMILES CN(CCO)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C20H22F2N6O2/c1-26(9-10-29)20(30)24-19-12-23-17-6-7-18(25-28(17)19)27-8-2-3-16(27)14-11-13(21)4-5-15(14)22/h4-7,11-12,16,29H,2-3,8-10H2,1H3,(H,24,30)/t16-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 10.3n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200578
PNG
(US10011604, 6 | US9227975, 6 | US9796723, 6)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccc2ncc(NC(=O)Nc3ccc(cc3)C#N)n2n1
Show InChI InChI=1/C24H19F2N7O/c25-16-5-8-19(26)18(12-16)20-2-1-11-32(20)22-10-9-21-28-14-23(33(21)31-22)30-24(34)29-17-6-3-15(13-27)4-7-17/h3-10,12,14,20H,1-2,11H2,(H2,29,30,34)/t20-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 10.7n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200610
PNG
(US10011604, 36 | US9227975, 36 | US9796723, 36)
Show SMILES C[C@@H]1CN(CCN1C(=O)OC(C)(C)C)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C27H33F2N7O3/c1-17-16-33(12-13-34(17)26(38)39-27(2,3)4)25(37)31-24-15-30-22-9-10-23(32-36(22)24)35-11-5-6-21(35)19-14-18(28)7-8-20(19)29/h7-10,14-15,17,21H,5-6,11-13,16H2,1-4H3,(H,31,37)/t17-,21-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 13n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200590
PNG
(US10011604, 17 | US9227975, 17 | US9795611, 17)
Show SMILES CC(C)(C)OC(=O)NC1CCCN(C1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C27H33F2N7O3/c1-27(2,3)39-26(38)31-18-6-4-12-34(16-18)25(37)32-24-15-30-22-10-11-23(33-36(22)24)35-13-5-7-21(35)19-14-17(28)8-9-20(19)29/h8-11,14-15,18,21H,4-7,12-13,16H2,1-3H3,(H,31,38)(H,32,37)/t18?,21-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 13.8n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200598
PNG
(US10011604, 25 | US9227975, 25 | US9796723, 25)
Show SMILES OC1CCN(CC1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C22H24F2N6O2/c23-14-3-4-17(24)16(12-14)18-2-1-9-29(18)20-6-5-19-25-13-21(30(19)27-20)26-22(32)28-10-7-15(31)8-11-28/h3-6,12-13,15,18,31H,1-2,7-11H2,(H,26,32)/t18-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 13.8n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM402220
PNG
(US10011604, 52)
Show SMILES OCC1CN(C1)c1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C20H21F2N5O/c21-14-3-4-16(22)15(8-14)17-2-1-7-26(17)19-6-5-18-23-9-20(27(18)24-19)25-10-13(11-25)12-28/h3-6,8-9,13,17,28H,1-2,7,10-12H2/t17-/m1/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 14n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200583
PNG
(US10011604, 11 | US9227975, 11 | US9795611, 11)
Show SMILES O[C@@H]1CCN(C1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C21H22F2N6O2/c22-13-3-4-16(23)15(10-13)17-2-1-8-28(17)19-6-5-18-24-11-20(29(18)26-19)25-21(31)27-9-7-14(30)12-27/h3-6,10-11,14,17,30H,1-2,7-9,12H2,(H,25,31)/t14-,17-/s2
PDB
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UniChem
US Patent
n/an/a 15.5n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200628
PNG
(US10011604, 53 | US9227975, 53 | US9796723, 53)
Show SMILES COC1CN(C1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C21H22F2N6O2/c1-31-14-11-27(12-14)21(30)25-20-10-24-18-6-7-19(26-29(18)20)28-8-2-3-17(28)15-9-13(22)4-5-16(15)23/h4-7,9-10,14,17H,2-3,8,11-12H2,1H3,(H,25,30)/t17-/s2
PDB
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n/an/a 16.4n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200635
PNG
(US10011604, 59 | US9227975, 59 | US9796723, 59)
Show SMILES OC1(CCN(CC1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F)C(F)(F)F
Show InChI InChI=1/C23H23F5N6O2/c24-14-3-4-16(25)15(12-14)17-2-1-9-33(17)19-6-5-18-29-13-20(34(18)31-19)30-21(35)32-10-7-22(36,8-11-32)23(26,27)28/h3-6,12-13,17,36H,1-2,7-11H2,(H,30,35)/t17-/s2
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n/an/a 16.5n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200585
PNG
(US10011604, 12 | US9227975, 12 | US9795611, 12)
Show SMILES CC(C)(C)OC(=O)NC1CCN(CC1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C27H33F2N7O3/c1-27(2,3)39-26(38)31-18-10-13-34(14-11-18)25(37)32-24-16-30-22-8-9-23(33-36(22)24)35-12-4-5-21(35)19-15-17(28)6-7-20(19)29/h6-9,15-16,18,21H,4-5,10-14H2,1-3H3,(H,31,38)(H,32,37)/t21-/s2
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n/an/a 17.2n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200620
PNG
(US10011604, 46 | US9227975, 46 | US9796723, 46)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccc2ncc(NC(=O)N3CCC3)n2n1
Show InChI InChI=1/C20H20F2N6O/c21-13-4-5-15(22)14(11-13)16-3-1-10-27(16)18-7-6-17-23-12-19(28(17)25-18)24-20(29)26-8-2-9-26/h4-7,11-12,16H,1-3,8-10H2,(H,24,29)/t16-/s2
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n/an/a 17.9n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200589
PNG
(US10011604, 16 | US9227975, 16 | US9795611, 16)
Show SMILES CN(C)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C19H20F2N6O/c1-25(2)19(28)23-18-11-22-16-7-8-17(24-27(16)18)26-9-3-4-15(26)13-10-12(20)5-6-14(13)21/h5-8,10-11,15H,3-4,9H2,1-2H3,(H,23,28)/t15-/s2
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n/an/a 18n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200631
PNG
(US10011604, 55 | US9227975, 55 | US9795611, 55)
Show SMILES CC(C)C(=O)OC1CN(C1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C24H26F2N6O3/c1-14(2)23(33)35-16-12-30(13-16)24(34)28-22-11-27-20-7-8-21(29-32(20)22)31-9-3-4-19(31)17-10-15(25)5-6-18(17)26/h5-8,10-11,14,16,19H,3-4,9,12-13H2,1-2H3,(H,28,34)/t19-/s2
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n/an/a 19.4n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200605
PNG
(US10011604, 31 | US9227975, 31 | US9796723, 31)
Show SMILES CCOC(=O)C1CCN(CC1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C25H28F2N6O3/c1-2-36-24(34)16-9-12-31(13-10-16)25(35)29-23-15-28-21-7-8-22(30-33(21)23)32-11-3-4-20(32)18-14-17(26)5-6-19(18)27/h5-8,14-16,20H,2-4,9-13H2,1H3,(H,29,35)/t20-/s2
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n/an/a 20.1n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM402228
PNG
(US10011604, 60)
Show SMILES Fc1ccc(F)c(c1)[C@@H]1CCCN1c1ccc2ncc(NC(=O)C(F)(F)F)n2n1
Show InChI InChI=1S/C18H14F5N5O/c19-10-3-4-12(20)11(8-10)13-2-1-7-27(13)15-6-5-14-24-9-16(28(14)26-15)25-17(29)18(21,22)23/h3-6,8-9,13H,1-2,7H2,(H,25,29)/t13-/m0/s1
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n/an/a 22n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200618
PNG
(US10011604, 44 | US9227975, 44 | US9796723, 44)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccc2ncc(NC(=O)N3CCC(F)(F)C3)n2n1
Show InChI InChI=1/C21H20F4N6O/c22-13-3-4-15(23)14(10-13)16-2-1-8-30(16)18-6-5-17-26-11-19(31(17)28-18)27-20(32)29-9-7-21(24,25)12-29/h3-6,10-11,16H,1-2,7-9,12H2,(H,27,32)/t16-/s2
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n/an/a 22.7n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200587
PNG
(US10011604, 14 | US9227975, 14 | US9795611, 14)
Show SMILES CC(C)(C)OC(=O)NC1CN(C1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C25H29F2N7O3/c1-25(2,3)37-24(36)29-16-13-32(14-16)23(35)30-22-12-28-20-8-9-21(31-34(20)22)33-10-4-5-19(33)17-11-15(26)6-7-18(17)27/h6-9,11-12,16,19H,4-5,10,13-14H2,1-3H3,(H,29,36)(H,30,35)/t19-/s2
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n/an/a 23.2n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200574
PNG
(US10011604, 2 | US9227975, 2 | US9795611, 2)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccc2ncc(NC(=O)N3CCOCC3)n2n1
Show InChI InChI=1/C21H22F2N6O2/c22-14-3-4-16(23)15(12-14)17-2-1-7-28(17)19-6-5-18-24-13-20(29(18)26-19)25-21(30)27-8-10-31-11-9-27/h3-6,12-13,17H,1-2,7-11H2,(H,25,30)/t17-/s2
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n/an/a 23.7n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200616
PNG
(US10011604, 42 | US9227975, 42 | US9796723, 42)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccc2ncc(NC(=O)N3CCNC(=O)C3)n2n1
Show InChI InChI=1/C21H21F2N7O2/c22-13-3-4-15(23)14(10-13)16-2-1-8-29(16)18-6-5-17-25-11-19(30(17)27-18)26-21(32)28-9-7-24-20(31)12-28/h3-6,10-11,16H,1-2,7-9,12H2,(H,24,31)(H,26,32)/t16-/s2
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n/an/a 26.2n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200625
PNG
(US10011604, 51 | US9227975, 51 | US9796723, 51)
Show SMILES CC(C)[C@H]1CN(CCN1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C24H29F2N7O/c1-15(2)19-14-31(11-9-27-19)24(34)29-23-13-28-21-7-8-22(30-33(21)23)32-10-3-4-20(32)17-12-16(25)5-6-18(17)26/h5-8,12-13,15,19-20,27H,3-4,9-11,14H2,1-2H3,(H,29,34)/t19-,20-/s2
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n/an/a 27.7n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM402206
PNG
(US10011604, 39)
Show SMILES C[C@H]1CN(CCN1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C22H25F2N7O/c1-14-13-29(10-8-25-14)22(32)27-21-12-26-19-6-7-20(28-31(19)21)30-9-2-3-18(30)16-11-15(23)4-5-17(16)24/h4-7,11-12,14,18,25H,2-3,8-10,13H2,1H3,(H,27,32)/t14-,18-/m0/s1
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n/an/a 29.9n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200588
PNG
(US10011604, 15 | US9227975, 15 | US9795611, 15)
Show SMILES CC(C)(C)OC(=O)N1CCN(CC1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C26H31F2N7O3/c1-26(2,3)38-25(37)33-13-11-32(12-14-33)24(36)30-23-16-29-21-8-9-22(31-35(21)23)34-10-4-5-20(34)18-15-17(27)6-7-19(18)28/h6-9,15-16,20H,4-5,10-14H2,1-3H3,(H,30,36)/t20-/s2
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n/an/a 33.6n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200579
PNG
(US10011604, 7 | US9227975, 7 | US9795611, 7)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccc2ncc(NC(=O)Nc3ccc(Cl)cc3Cl)n2n1
Show InChI InChI=1/C23H18Cl2F2N6O/c24-13-3-6-18(16(25)10-13)29-23(34)30-22-12-28-20-7-8-21(31-33(20)22)32-9-1-2-19(32)15-11-14(26)4-5-17(15)27/h3-8,10-12,19H,1-2,9H2,(H2,29,30,34)/t19-/s2
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n/an/a 39.4n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200611
PNG
(US10011604, 37 | US9227975, 37 | US9796723, 37)
Show SMILES C[C@H]1CN(CCN1C(=O)OC(C)(C)C)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C27H33F2N7O3/c1-17-16-33(12-13-34(17)26(38)39-27(2,3)4)25(37)31-24-15-30-22-9-10-23(32-36(22)24)35-11-5-6-21(35)19-14-18(28)7-8-20(19)29/h7-10,14-15,17,21H,5-6,11-13,16H2,1-4H3,(H,31,37)/t17-,21+/s2
PDB
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n/an/a 40.6n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200594
PNG
(US10011604, 21 | US9227975, 21 | US9795611, 21)
Show SMILES NC1CCCN(C1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C22H25F2N7O/c23-14-5-6-17(24)16(11-14)18-4-2-10-30(18)20-8-7-19-26-12-21(31(19)28-20)27-22(32)29-9-1-3-15(25)13-29/h5-8,11-12,15,18H,1-4,9-10,13,25H2,(H,27,32)/t15?,18-/s2
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n/an/a 42n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM402205
PNG
(US10011604, 38)
Show SMILES C[C@@H]1CN(CCN1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C22H25F2N7O/c1-14-13-29(10-8-25-14)22(32)27-21-12-26-19-6-7-20(28-31(19)21)30-9-2-3-18(30)16-11-15(23)4-5-17(16)24/h4-7,11-12,14,18,25H,2-3,8-10,13H2,1H3,(H,27,32)/t14-,18+/m1/s1
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n/an/a 47.9n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200609
PNG
(US10011604, 35 | US9227975, 35 | US9796723, 35)
Show SMILES CC1CN(CC(C)N1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C23H27F2N7O/c1-14-12-30(13-15(2)27-14)23(33)28-22-11-26-20-7-8-21(29-32(20)22)31-9-3-4-19(31)17-10-16(24)5-6-18(17)25/h5-8,10-11,14-15,19,27H,3-4,9,12-13H2,1-2H3,(H,28,33)/t14?,15?,19-/s2
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n/an/a 49.6n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200591
PNG
(US10011604, 18 | US9227975, 18 | US9795611, 18)
Show SMILES NC1CCN(CC1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C22H25F2N7O/c23-14-3-4-17(24)16(12-14)18-2-1-9-30(18)20-6-5-19-26-13-21(31(19)28-20)27-22(32)29-10-7-15(25)8-11-29/h3-6,12-13,15,18H,1-2,7-11,25H2,(H,27,32)/t18-/s2
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n/an/a 52.9n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200634
PNG
(US10011604, 58 | US9227975, 58 | US9796723, 58)
Show SMILES CN1CCN(CC1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C22H25F2N7O/c1-28-9-11-29(12-10-28)22(32)26-21-14-25-19-6-7-20(27-31(19)21)30-8-2-3-18(30)16-13-15(23)4-5-17(16)24/h4-7,13-14,18H,2-3,8-12H2,1H3,(H,26,32)/t18-/s2
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n/an/a 53.2n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200624
PNG
(US10011604, 50 | US9227975, 50 | US9796723, 50)
Show SMILES CC1(C)CN(CCN1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C23H27F2N7O/c1-23(2)14-30(11-9-27-23)22(33)28-21-13-26-19-7-8-20(29-32(19)21)31-10-3-4-18(31)16-12-15(24)5-6-17(16)25/h5-8,12-13,18,27H,3-4,9-11,14H2,1-2H3,(H,28,33)/t18-/s2
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n/an/a 60.6n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200608
PNG
(US10011604, 34 | US9227975, 34 | US9796723, 34)
Show SMILES OC(=O)C1CCN(CC1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C23H24F2N6O3/c24-15-3-4-17(25)16(12-15)18-2-1-9-30(18)20-6-5-19-26-13-21(31(19)28-20)27-23(34)29-10-7-14(8-11-29)22(32)33/h3-6,12-14,18H,1-2,7-11H2,(H,27,34)(H,32,33)/t18-/s2
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n/an/a 64.4n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200602
PNG
(US10011604, 28 | US9227975, 28 | US9796723, 28)
Show SMILES CNC(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C18H18F2N6O/c1-21-18(27)23-17-10-22-15-6-7-16(24-26(15)17)25-8-2-3-14(25)12-9-11(19)4-5-13(12)20/h4-7,9-10,14H,2-3,8H2,1H3,(H2,21,23,27)/t14-/s2
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n/an/a 65.7n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200577
PNG
(US10011604, 5 | US9227975, 5 | US9795611, 5)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccc2ncc(NC(=O)Nc3cccc(c3)C#N)n2n1
Show InChI InChI=1/C24H19F2N7O/c25-16-6-7-19(26)18(12-16)20-5-2-10-32(20)22-9-8-21-28-14-23(33(21)31-22)30-24(34)29-17-4-1-3-15(11-17)13-27/h1,3-4,6-9,11-12,14,20H,2,5,10H2,(H2,29,30,34)/t20-/s2
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n/an/a 74.2n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200596
PNG
(US10011604, 23 | US9227975, 23 | US9796723, 23)
Show SMILES CC(C)(C)OC(=O)N1C2CCC1CN(C2)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C28H33F2N7O3/c1-28(2,3)40-27(39)36-18-7-8-19(36)16-34(15-18)26(38)32-25-14-31-23-10-11-24(33-37(23)25)35-12-4-5-22(35)20-13-17(29)6-9-21(20)30/h6,9-11,13-14,18-19,22H,4-5,7-8,12,15-16H2,1-3H3,(H,32,38)/t18?,19?,22-/s2
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n/an/a 75.5n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200601
PNG
(US10011604, 27 | US9227975, 27 | US9796723, 27)
Show SMILES NC(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C17H16F2N6O/c18-10-3-4-12(19)11(8-10)13-2-1-7-24(13)15-6-5-14-21-9-16(22-17(20)26)25(14)23-15/h3-6,8-9,13H,1-2,7H2,(H3,20,22,26)/t13-/s2
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n/an/a 77.1n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200619
PNG
(US10011604, 45 | US9227975, 45 | US9796723, 45)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccc2ncc(NC(=O)N3CC(F)(F)C3)n2n1
Show InChI InChI=1/C20H18F4N6O/c21-12-3-4-14(22)13(8-12)15-2-1-7-29(15)17-6-5-16-25-9-18(30(16)27-17)26-19(31)28-10-20(23,24)11-28/h3-6,8-9,15H,1-2,7,10-11H2,(H,26,31)/t15-/s2
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n/an/a 92n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200593
PNG
(US10011604, 20 | US9227975, 20 | US9795611, 20)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccc2ncc(NC(=O)N3CCNCC3)n2n1
Show InChI InChI=1/C21H23F2N7O/c22-14-3-4-16(23)15(12-14)17-2-1-9-29(17)19-6-5-18-25-13-20(30(18)27-19)26-21(31)28-10-7-24-8-11-28/h3-6,12-13,17,24H,1-2,7-11H2,(H,26,31)/t17-/s2
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n/an/a 94.7n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200597
PNG
(US10011604, 24 | US9227975, 24 | US9796723, 24)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccc2ncc(NC(=O)N3CC4CCC(C3)N4)n2n1
Show InChI InChI=1/C23H25F2N7O/c24-14-3-6-18(25)17(10-14)19-2-1-9-31(19)21-8-7-20-26-11-22(32(20)29-21)28-23(33)30-12-15-4-5-16(13-30)27-15/h3,6-8,10-11,15-16,19,27H,1-2,4-5,9,12-13H2,(H,28,33)/t15?,16?,19-/s2
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n/an/a 107n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200592
PNG
(US10011604, 19 | US9227975, 19 | US9795611, 19)
Show SMILES NC1CN(C1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C20H21F2N7O/c21-12-3-4-15(22)14(8-12)16-2-1-7-28(16)18-6-5-17-24-9-19(29(17)26-18)25-20(30)27-10-13(23)11-27/h3-6,8-9,13,16H,1-2,7,10-11,23H2,(H,25,30)/t16-/s2
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n/an/a 126n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200606
PNG
(US10011604, 32 | US9227975, 32 | US9796723, 32)
Show SMILES COc1cc(NC(=O)Nc2cnc3ccc(nn23)N2CCC[C@@H]2c2cc(F)ccc2F)cc(OC)c1OC
Show InChI InChI=1/C26H26F2N6O4/c1-36-20-12-16(13-21(37-2)25(20)38-3)30-26(35)31-24-14-29-22-8-9-23(32-34(22)24)33-10-4-5-19(33)17-11-15(27)6-7-18(17)28/h6-9,11-14,19H,4-5,10H2,1-3H3,(H2,30,31,35)/t19-/s2
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n/an/a 176n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200617
PNG
(US10011604, 43 | US9227975, 43 | US9796723, 43)
Show SMILES OC1CN(C1)C(=O)Nc1cnc2ccc(nn12)N1CCCCC1c1cccc(F)c1
Show InChI InChI=1/C21H23FN6O2/c22-15-5-3-4-14(10-15)17-6-1-2-9-27(17)19-8-7-18-23-11-20(28(18)25-19)24-21(30)26-12-16(29)13-26/h3-5,7-8,10-11,16-17,29H,1-2,6,9,12-13H2,(H,24,30)
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n/an/a 216n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200580
PNG
(US10011604, 8 | US9227975, 8 | US9795611, 8)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccc2ncc(NC(=O)Nc3cccc(c3)C(F)(F)F)n2n1
Show InChI InChI=1/C24H19F5N6O/c25-15-6-7-18(26)17(12-15)19-5-2-10-34(19)21-9-8-20-30-13-22(35(20)33-21)32-23(36)31-16-4-1-3-14(11-16)24(27,28)29/h1,3-4,6-9,11-13,19H,2,5,10H2,(H2,31,32,36)/t19-/s2
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n/an/a 508n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200581
PNG
(US10011604, 9 | US9227975, 9 | US9795611, 9)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccc2ncc(NC(=O)Nc3cc(Cl)cc(Cl)c3)n2n1
Show InChI InChI=1/C23H18Cl2F2N6O/c24-13-8-14(25)10-16(9-13)29-23(34)30-22-12-28-20-5-6-21(31-33(20)22)32-7-1-2-19(32)17-11-15(26)3-4-18(17)27/h3-6,8-12,19H,1-2,7H2,(H2,29,30,34)/t19-/s2
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n/an/a 717n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200623
PNG
(US10011604, 49 | US9227975, 49 | US9796723, 49)
Show SMILES CC(C)[C@H]1CN(CCN1C(=O)OC(C)(C)C)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C29H37F2N7O3/c1-18(2)23-17-35(13-14-37(23)28(40)41-29(3,4)5)27(39)33-26-16-32-24-10-11-25(34-38(24)26)36-12-6-7-22(36)20-15-19(30)8-9-21(20)31/h8-11,15-16,18,22-23H,6-7,12-14,17H2,1-5H3,(H,33,39)/t22-,23-/s2
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n/an/a 857n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200615
PNG
(US10011604, 41 | US9227975, 41)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccc2ncc(NC(=O)N3CCS(=O)(=O)CC3)n2n1
Show InChI InChI=1/C21H22F2N6O3S/c22-14-3-4-16(23)15(12-14)17-2-1-7-28(17)19-6-5-18-24-13-20(29(18)26-19)25-21(30)27-8-10-33(31,32)11-9-27/h3-6,12-13,17H,1-2,7-11H2,(H,25,30)/t17-/s2
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n/an/a 884n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200607
PNG
(US10011604, 33 | US9227975, 33 | US9796723, 33)
Show SMILES Cc1noc(C)c1NC(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C22H21F2N7O2/c1-12-21(13(2)33-29-12)27-22(32)26-20-11-25-18-7-8-19(28-31(18)20)30-9-3-4-17(30)15-10-14(23)5-6-16(15)24/h5-8,10-11,17H,3-4,9H2,1-2H3,(H2,26,27,32)/t17-/s2
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n/an/a 901n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%