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Patent code US10011604

Compile Data Set for Download or QSAR
Found 60 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200576
PNG
(US10011604, 4 | US10590139, Example 4 | US9227975,...)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C24H22F2N6O3S/c1-36(34,35)30-17-7-4-15(5-8-17)24(33)28-23-14-27-21-10-11-22(29-32(21)23)31-12-2-3-20(31)18-13-16(25)6-9-19(18)26/h4-11,13-14,20,30H,2-3,12H2,1H3,(H,28,33)/t20-/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q2RB76ZK
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200614
PNG
(US10011604, 40 | US10590139, Example 40 | US922797...)
Show SMILES O[C@@H]1CN(C[C@H]1O)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C21H22F2N6O3/c22-12-3-4-14(23)13(8-12)15-2-1-7-28(15)19-6-5-18-24-9-20(29(18)26-19)25-21(32)27-10-16(30)17(31)11-27/h3-6,8-9,15-17,30-31H,1-2,7,10-11H2,(H,25,32)/t15-,16-,17-/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q2RB76ZK
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200633
PNG
(US10011604, 57 | US10590139, Example 57 | US922797...)
Show SMILES Cn1nc(ccc1=O)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C22H19F2N7O2/c1-29-21(32)9-6-16(27-29)22(33)26-20-12-25-18-7-8-19(28-31(18)20)30-10-2-3-17(30)14-11-13(23)4-5-15(14)24/h4-9,11-12,17H,2-3,10H2,1H3,(H,26,33)/t17-/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q2RB76ZK
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200582
PNG
(US10011604, 10 | US10590139, Example 10 | US922797...)
Show SMILES O[C@H]1CCN(C1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C21H22F2N6O2/c22-13-3-4-16(23)15(10-13)17-2-1-8-28(17)19-6-5-18-24-11-20(29(18)26-19)25-21(31)27-9-7-14(30)12-27/h3-6,10-11,14,17,30H,1-2,7-9,12H2,(H,25,31)/t14-,17+/m0/s1
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Array BioPharma Inc

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q2RB76ZK
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200575
PNG
(US10011604, 3 | US10590139, Example 3 | US9227975,...)
Show SMILES CC(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C18H17F2N5O/c1-11(26)22-18-10-21-16-6-7-17(23-25(16)18)24-8-2-3-15(24)13-9-12(19)4-5-14(13)20/h4-7,9-10,15H,2-3,8H2,1H3,(H,22,26)/t15-/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q2RB76ZK
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200604
PNG
(US10011604, 30 | US10590139, Example 30 | US922797...)
Show SMILES COc1ccc(NC(=O)Nc2cnc3ccc(nn23)N2CCC[C@@H]2c2cc(F)ccc2F)cc1
Show InChI InChI=1S/C24H22F2N6O2/c1-34-17-7-5-16(6-8-17)28-24(33)29-23-14-27-21-10-11-22(30-32(21)23)31-12-2-3-20(31)18-13-15(25)4-9-19(18)26/h4-11,13-14,20H,2-3,12H2,1H3,(H2,28,29,33)/t20-/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q2RB76ZK
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200599
PNG
(US10011604, 26 | US10590139, Example 26 | US922797...)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccc2ncc(NC(=O)N3CCCCC3)n2n1
Show InChI InChI=1S/C22H24F2N6O/c23-15-6-7-17(24)16(13-15)18-5-4-12-29(18)20-9-8-19-25-14-21(30(19)27-20)26-22(31)28-10-2-1-3-11-28/h6-9,13-14,18H,1-5,10-12H2,(H,26,31)/t18-/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q2RB76ZK
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200622
PNG
(US10011604, 48 | US10590139, Example 48 | US922797...)
Show SMILES CC(C)(C)OC(=O)N1CCN(CC1(C)C)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C28H35F2N7O3/c1-27(2,3)40-26(39)36-14-13-34(17-28(36,4)5)25(38)32-24-16-31-22-10-11-23(33-37(22)24)35-12-6-7-21(35)19-15-18(29)8-9-20(19)30/h8-11,15-16,21H,6-7,12-14,17H2,1-5H3,(H,32,38)/t21-/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q2RB76ZK
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200573
PNG
(US10011604, 1 | US10590139, Example 1 | US9227975,...)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccc2ncc(NC(=O)Nc3ccccc3)n2n1
Show InChI InChI=1S/C23H20F2N6O/c24-15-8-9-18(25)17(13-15)19-7-4-12-30(19)21-11-10-20-26-14-22(31(20)29-21)28-23(32)27-16-5-2-1-3-6-16/h1-3,5-6,8-11,13-14,19H,4,7,12H2,(H2,27,28,32)/t19-/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q2RB76ZK
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200629
PNG
(US10011604, 54 | US10590139, Example 54 | US922797...)
Show SMILES CC1(O)CN(C1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C21H22F2N6O2/c1-21(31)11-27(12-21)20(30)25-19-10-24-17-6-7-18(26-29(17)19)28-8-2-3-16(28)14-9-13(22)4-5-15(14)23/h4-7,9-10,16,31H,2-3,8,11-12H2,1H3,(H,25,30)/t16-/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q2RB76ZK
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200586
PNG
(US10011604, 13 | US10590139, Example 13 | US922797...)
Show SMILES OC1CN(C1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C20H20F2N6O2/c21-12-3-4-15(22)14(8-12)16-2-1-7-27(16)18-6-5-17-23-9-19(28(17)25-18)24-20(30)26-10-13(29)11-26/h3-6,8-9,13,16,29H,1-2,7,10-11H2,(H,24,30)/t16-/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q2RB76ZK
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200603
PNG
(US10011604, 29 | US10590139, Example 29 | US922797...)
Show SMILES CC(C)(C)NC(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C21H24F2N6O/c1-21(2,3)26-20(30)25-19-12-24-17-8-9-18(27-29(17)19)28-10-4-5-16(28)14-11-13(22)6-7-15(14)23/h6-9,11-12,16H,4-5,10H2,1-3H3,(H2,25,26,30)/t16-/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q2RB76ZK
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200595
PNG
(US10011604, 22 | US10590139, Example 22 | US922797...)
Show SMILES Fc1ccc(NC(=O)Nc2cnc3ccc(nn23)N2CCC[C@@H]2c2cc(F)ccc2F)cc1
Show InChI InChI=1S/C23H19F3N6O/c24-14-3-6-16(7-4-14)28-23(33)29-22-13-27-20-9-10-21(30-32(20)22)31-11-1-2-19(31)17-12-15(25)5-8-18(17)26/h3-10,12-13,19H,1-2,11H2,(H2,28,29,33)/t19-/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q2RB76ZK
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200632
PNG
(US10011604, 56 | US10590139, Example 56 | US922797...)
Show SMILES Cn1cc(ccc1=O)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C23H20F2N6O2/c1-29-13-14(4-9-22(29)32)23(33)27-21-12-26-19-7-8-20(28-31(19)21)30-10-2-3-18(30)16-11-15(24)5-6-17(16)25/h4-9,11-13,18H,2-3,10H2,1H3,(H,27,33)/t18-/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q2RB76ZK
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200621
PNG
(US10011604, 47 | US10590139, Example 47 | US922797...)
Show SMILES CN(CCO)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C20H22F2N6O2/c1-26(9-10-29)20(30)24-19-12-23-17-6-7-18(25-28(17)19)27-8-2-3-16(27)14-11-13(21)4-5-15(14)22/h4-7,11-12,16,29H,2-3,8-10H2,1H3,(H,24,30)/t16-/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q2RB76ZK
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200578
PNG
(US10011604, 6 | US10590139, Example 6 | US9227975,...)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccc2ncc(NC(=O)Nc3ccc(cc3)C#N)n2n1
Show InChI InChI=1S/C24H19F2N7O/c25-16-5-8-19(26)18(12-16)20-2-1-11-32(20)22-10-9-21-28-14-23(33(21)31-22)30-24(34)29-17-6-3-15(13-27)4-7-17/h3-10,12,14,20H,1-2,11H2,(H2,29,30,34)/t20-/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q2RB76ZK
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200610
PNG
(US10011604, 36 | US10590139, Example 36 | US922797...)
Show SMILES C[C@@H]1CN(CCN1C(=O)OC(C)(C)C)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C27H33F2N7O3/c1-17-16-33(12-13-34(17)26(38)39-27(2,3)4)25(37)31-24-15-30-22-9-10-23(32-36(22)24)35-11-5-6-21(35)19-14-18(28)7-8-20(19)29/h7-10,14-15,17,21H,5-6,11-13,16H2,1-4H3,(H,31,37)/t17-,21-/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q2RB76ZK
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200590
PNG
(US10011604, 17 | US10590139, Example 17 | US922797...)
Show SMILES CC(C)(C)OC(=O)NC1CCCN(C1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C27H33F2N7O3/c1-27(2,3)39-26(38)31-18-6-4-12-34(16-18)25(37)32-24-15-30-22-10-11-23(33-36(22)24)35-13-5-7-21(35)19-14-17(28)8-9-20(19)29/h8-11,14-15,18,21H,4-7,12-13,16H2,1-3H3,(H,31,38)(H,32,37)/t18?,21-/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q2RB76ZK
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200598
PNG
(US10011604, 25 | US10590139, Example 25 | US922797...)
Show SMILES OC1CCN(CC1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C22H24F2N6O2/c23-14-3-4-17(24)16(12-14)18-2-1-9-29(18)20-6-5-19-25-13-21(30(19)27-20)26-22(32)28-10-7-15(31)8-11-28/h3-6,12-13,15,18,31H,1-2,7-11H2,(H,26,32)/t18-/m1/s1
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n/an/a 13.8n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q2RB76ZK
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM402220
PNG
(US10011604, 52)
Show SMILES OCC1CN(C1)c1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C20H21F2N5O/c21-14-3-4-16(22)15(8-14)17-2-1-7-26(17)19-6-5-18-23-9-20(27(18)24-19)25-10-13(11-25)12-28/h3-6,8-9,13,17,28H,1-2,7,10-12H2/t17-/m1/s1
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n/an/a 14n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q2RB76ZK
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200583
PNG
(US10011604, 11 | US10590139, Example 11 | US922797...)
Show SMILES O[C@@H]1CCN(C1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C21H22F2N6O2/c22-13-3-4-16(23)15(10-13)17-2-1-8-28(17)19-6-5-18-24-11-20(29(18)26-19)25-21(31)27-9-7-14(30)12-27/h3-6,10-11,14,17,30H,1-2,7-9,12H2,(H,25,31)/t14-,17-/m1/s1
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n/an/a 15.5n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q2RB76ZK
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200628
PNG
(US10011604, 53 | US10590139, Example 53 | US922797...)
Show SMILES COC1CN(C1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C21H22F2N6O2/c1-31-14-11-27(12-14)21(30)25-20-10-24-18-6-7-19(26-29(18)20)28-8-2-3-17(28)15-9-13(22)4-5-16(15)23/h4-7,9-10,14,17H,2-3,8,11-12H2,1H3,(H,25,30)/t17-/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q2RB76ZK
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200635
PNG
(US10011604, 59 | US10590139, Example 59 | US922797...)
Show SMILES OC1(CCN(CC1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F)C(F)(F)F
Show InChI InChI=1S/C23H23F5N6O2/c24-14-3-4-16(25)15(12-14)17-2-1-9-33(17)19-6-5-18-29-13-20(34(18)31-19)30-21(35)32-10-7-22(36,8-11-32)23(26,27)28/h3-6,12-13,17,36H,1-2,7-11H2,(H,30,35)/t17-/m1/s1
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n/an/a 16.5n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q2RB76ZK
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200585
PNG
(US10011604, 12 | US10590139, Example 12 | US922797...)
Show SMILES CC(C)(C)OC(=O)NC1CCN(CC1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C27H33F2N7O3/c1-27(2,3)39-26(38)31-18-10-13-34(14-11-18)25(37)32-24-16-30-22-8-9-23(33-36(22)24)35-12-4-5-21(35)19-15-17(28)6-7-20(19)29/h6-9,15-16,18,21H,4-5,10-14H2,1-3H3,(H,31,38)(H,32,37)/t21-/m1/s1
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n/an/a 17.2n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q2RB76ZK
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200620
PNG
(US10011604, 46 | US10590139, Example 46 | US922797...)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccc2ncc(NC(=O)N3CCC3)n2n1
Show InChI InChI=1S/C20H20F2N6O/c21-13-4-5-15(22)14(11-13)16-3-1-10-27(16)18-7-6-17-23-12-19(28(17)25-18)24-20(29)26-8-2-9-26/h4-7,11-12,16H,1-3,8-10H2,(H,24,29)/t16-/m1/s1
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n/an/a 17.9n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q2RB76ZK
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200589
PNG
(US10011604, 16 | US10590139, Example 16 | US922797...)
Show SMILES CN(C)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C19H20F2N6O/c1-25(2)19(28)23-18-11-22-16-7-8-17(24-27(16)18)26-9-3-4-15(26)13-10-12(20)5-6-14(13)21/h5-8,10-11,15H,3-4,9H2,1-2H3,(H,23,28)/t15-/m1/s1
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n/an/a 18n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q2RB76ZK
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200631
PNG
(US10011604, 55 | US10590139, Example 55 | US922797...)
Show SMILES CC(C)C(=O)OC1CN(C1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C24H26F2N6O3/c1-14(2)23(33)35-16-12-30(13-16)24(34)28-22-11-27-20-7-8-21(29-32(20)22)31-9-3-4-19(31)17-10-15(25)5-6-18(17)26/h5-8,10-11,14,16,19H,3-4,9,12-13H2,1-2H3,(H,28,34)/t19-/m1/s1
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n/an/a 19.4n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q2RB76ZK
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200605
PNG
(US10011604, 31 | US10590139, Example 31 | US922797...)
Show SMILES CCOC(=O)C1CCN(CC1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C25H28F2N6O3/c1-2-36-24(34)16-9-12-31(13-10-16)25(35)29-23-15-28-21-7-8-22(30-33(21)23)32-11-3-4-20(32)18-14-17(26)5-6-19(18)27/h5-8,14-16,20H,2-4,9-13H2,1H3,(H,29,35)/t20-/m1/s1
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n/an/a 20.1n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q2RB76ZK
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM402228
PNG
(US10011604, 60)
Show SMILES Fc1ccc(F)c(c1)[C@@H]1CCCN1c1ccc2ncc(NC(=O)C(F)(F)F)n2n1
Show InChI InChI=1S/C18H14F5N5O/c19-10-3-4-12(20)11(8-10)13-2-1-7-27(13)15-6-5-14-24-9-16(28(14)26-15)25-17(29)18(21,22)23/h3-6,8-9,13H,1-2,7H2,(H,25,29)/t13-/m0/s1
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n/an/a 22n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q2RB76ZK
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200618
PNG
(US10011604, 44 | US10590139, Example 44 | US922797...)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccc2ncc(NC(=O)N3CCC(F)(F)C3)n2n1
Show InChI InChI=1S/C21H20F4N6O/c22-13-3-4-15(23)14(10-13)16-2-1-8-30(16)18-6-5-17-26-11-19(31(17)28-18)27-20(32)29-9-7-21(24,25)12-29/h3-6,10-11,16H,1-2,7-9,12H2,(H,27,32)/t16-/m1/s1
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n/an/a 22.7n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q2RB76ZK
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200587
PNG
(US10011604, 14 | US10590139, Example 14 | US922797...)
Show SMILES CC(C)(C)OC(=O)NC1CN(C1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C25H29F2N7O3/c1-25(2,3)37-24(36)29-16-13-32(14-16)23(35)30-22-12-28-20-8-9-21(31-34(20)22)33-10-4-5-19(33)17-11-15(26)6-7-18(17)27/h6-9,11-12,16,19H,4-5,10,13-14H2,1-3H3,(H,29,36)(H,30,35)/t19-/m1/s1
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n/an/a 23.2n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q2RB76ZK
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200574
PNG
(US10011604, 2 | US10590139, Example 2 | US9227975,...)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccc2ncc(NC(=O)N3CCOCC3)n2n1
Show InChI InChI=1S/C21H22F2N6O2/c22-14-3-4-16(23)15(12-14)17-2-1-7-28(17)19-6-5-18-24-13-20(29(18)26-19)25-21(30)27-8-10-31-11-9-27/h3-6,12-13,17H,1-2,7-11H2,(H,25,30)/t17-/m1/s1
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n/an/a 23.7n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q2RB76ZK
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200616
PNG
(US10011604, 42 | US10590139, Example 42 | US922797...)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccc2ncc(NC(=O)N3CCNC(=O)C3)n2n1
Show InChI InChI=1S/C21H21F2N7O2/c22-13-3-4-15(23)14(10-13)16-2-1-8-29(16)18-6-5-17-25-11-19(30(17)27-18)26-21(32)28-9-7-24-20(31)12-28/h3-6,10-11,16H,1-2,7-9,12H2,(H,24,31)(H,26,32)/t16-/m1/s1
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n/an/a 26.2n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q2RB76ZK
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200625
PNG
(US10011604, 51 | US10590139, Example 51 | US922797...)
Show SMILES CC(C)[C@H]1CN(CCN1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C24H29F2N7O/c1-15(2)19-14-31(11-9-27-19)24(34)29-23-13-28-21-7-8-22(30-33(21)23)32-10-3-4-20(32)17-12-16(25)5-6-18(17)26/h5-8,12-13,15,19-20,27H,3-4,9-11,14H2,1-2H3,(H,29,34)/t19-,20-/m1/s1
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n/an/a 27.7n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q2RB76ZK
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM402206
PNG
(US10011604, 39)
Show SMILES C[C@H]1CN(CCN1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C22H25F2N7O/c1-14-13-29(10-8-25-14)22(32)27-21-12-26-19-6-7-20(28-31(19)21)30-9-2-3-18(30)16-11-15(23)4-5-17(16)24/h4-7,11-12,14,18,25H,2-3,8-10,13H2,1H3,(H,27,32)/t14-,18-/m0/s1
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n/an/a 29.9n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q2RB76ZK
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200588
PNG
(US10011604, 15 | US10590139, Example 15 | US922797...)
Show SMILES CC(C)(C)OC(=O)N1CCN(CC1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C26H31F2N7O3/c1-26(2,3)38-25(37)33-13-11-32(12-14-33)24(36)30-23-16-29-21-8-9-22(31-35(21)23)34-10-4-5-20(34)18-15-17(27)6-7-19(18)28/h6-9,15-16,20H,4-5,10-14H2,1-3H3,(H,30,36)/t20-/m1/s1
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n/an/a 33.6n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q2RB76ZK
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200579
PNG
(US10011604, 7 | US10590139, Example 7 | US9227975,...)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccc2ncc(NC(=O)Nc3ccc(Cl)cc3Cl)n2n1
Show InChI InChI=1S/C23H18Cl2F2N6O/c24-13-3-6-18(16(25)10-13)29-23(34)30-22-12-28-20-7-8-21(31-33(20)22)32-9-1-2-19(32)15-11-14(26)4-5-17(15)27/h3-8,10-12,19H,1-2,9H2,(H2,29,30,34)/t19-/m1/s1
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n/an/a 39.4n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q2RB76ZK
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200611
PNG
(US10011604, 37 | US10590139, Example 37 | US922797...)
Show SMILES C[C@H]1CN(CCN1C(=O)OC(C)(C)C)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C27H33F2N7O3/c1-17-16-33(12-13-34(17)26(38)39-27(2,3)4)25(37)31-24-15-30-22-9-10-23(32-36(22)24)35-11-5-6-21(35)19-14-18(28)7-8-20(19)29/h7-10,14-15,17,21H,5-6,11-13,16H2,1-4H3,(H,31,37)/t17-,21+/m0/s1
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n/an/a 40.6n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q2RB76ZK
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200594
PNG
(US10011604, 21 | US10590139, Example 21 | US922797...)
Show SMILES NC1CCCN(C1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C22H25F2N7O/c23-14-5-6-17(24)16(11-14)18-4-2-10-30(18)20-8-7-19-26-12-21(31(19)28-20)27-22(32)29-9-1-3-15(25)13-29/h5-8,11-12,15,18H,1-4,9-10,13,25H2,(H,27,32)/t15?,18-/m1/s1
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n/an/a 42n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q2RB76ZK
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM402205
PNG
(US10011604, 38)
Show SMILES C[C@@H]1CN(CCN1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C22H25F2N7O/c1-14-13-29(10-8-25-14)22(32)27-21-12-26-19-6-7-20(28-31(19)21)30-9-2-3-18(30)16-11-15(23)4-5-17(16)24/h4-7,11-12,14,18,25H,2-3,8-10,13H2,1H3,(H,27,32)/t14-,18+/m1/s1
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n/an/a 47.9n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q2RB76ZK
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200609
PNG
(US10011604, 35 | US10590139, Example 35 | US922797...)
Show SMILES CC1CN(CC(C)N1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C23H27F2N7O/c1-14-12-30(13-15(2)27-14)23(33)28-22-11-26-20-7-8-21(29-32(20)22)31-9-3-4-19(31)17-10-16(24)5-6-18(17)25/h5-8,10-11,14-15,19,27H,3-4,9,12-13H2,1-2H3,(H,28,33)/t14?,15?,19-/m1/s1
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n/an/a 49.6n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q2RB76ZK
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200591
PNG
(US10011604, 18 | US10590139, Example 18 | US922797...)
Show SMILES NC1CCN(CC1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C22H25F2N7O/c23-14-3-4-17(24)16(12-14)18-2-1-9-30(18)20-6-5-19-26-13-21(31(19)28-20)27-22(32)29-10-7-15(25)8-11-29/h3-6,12-13,15,18H,1-2,7-11,25H2,(H,27,32)/t18-/m1/s1
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n/an/a 52.9n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q2RB76ZK
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200634
PNG
(US10011604, 58 | US10590139, Example 58 | US922797...)
Show SMILES CN1CCN(CC1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C22H25F2N7O/c1-28-9-11-29(12-10-28)22(32)26-21-14-25-19-6-7-20(27-31(19)21)30-8-2-3-18(30)16-13-15(23)4-5-17(16)24/h4-7,13-14,18H,2-3,8-12H2,1H3,(H,26,32)/t18-/m1/s1
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n/an/a 53.2n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q2RB76ZK
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200624
PNG
(US10011604, 50 | US10590139, Example 50 | US922797...)
Show SMILES CC1(C)CN(CCN1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C23H27F2N7O/c1-23(2)14-30(11-9-27-23)22(33)28-21-13-26-19-7-8-20(29-32(19)21)31-10-3-4-18(31)16-12-15(24)5-6-17(16)25/h5-8,12-13,18,27H,3-4,9-11,14H2,1-2H3,(H,28,33)/t18-/m1/s1
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n/an/a 60.6n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q2RB76ZK
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200608
PNG
(US10011604, 34 | US10590139, Example 34 | US922797...)
Show SMILES OC(=O)C1CCN(CC1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C23H24F2N6O3/c24-15-3-4-17(25)16(12-15)18-2-1-9-30(18)20-6-5-19-26-13-21(31(19)28-20)27-23(34)29-10-7-14(8-11-29)22(32)33/h3-6,12-14,18H,1-2,7-11H2,(H,27,34)(H,32,33)/t18-/m1/s1
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n/an/a 64.4n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q2RB76ZK
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200602
PNG
(US10011604, 28 | US10590139, Example 28 | US922797...)
Show SMILES CNC(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C18H18F2N6O/c1-21-18(27)23-17-10-22-15-6-7-16(24-26(15)17)25-8-2-3-14(25)12-9-11(19)4-5-13(12)20/h4-7,9-10,14H,2-3,8H2,1H3,(H2,21,23,27)/t14-/m1/s1
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n/an/a 65.7n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q2RB76ZK
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200577
PNG
(US10011604, 5 | US10590139, Example 5 | US9227975,...)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccc2ncc(NC(=O)Nc3cccc(c3)C#N)n2n1
Show InChI InChI=1S/C24H19F2N7O/c25-16-6-7-19(26)18(12-16)20-5-2-10-32(20)22-9-8-21-28-14-23(33(21)31-22)30-24(34)29-17-4-1-3-15(11-17)13-27/h1,3-4,6-9,11-12,14,20H,2,5,10H2,(H2,29,30,34)/t20-/m1/s1
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n/an/a 74.2n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q2RB76ZK
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200596
PNG
(US10011604, 23 | US9227975, 23 | US9796723, 23)
Show SMILES CC(C)(C)OC(=O)N1C2CCC1CN(C2)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C28H33F2N7O3/c1-28(2,3)40-27(39)36-18-7-8-19(36)16-34(15-18)26(38)32-25-14-31-23-10-11-24(33-37(23)25)35-12-4-5-22(35)20-13-17(29)6-9-21(20)30/h6,9-11,13-14,18-19,22H,4-5,7-8,12,15-16H2,1-3H3,(H,32,38)/t18?,19?,22-/m1/s1
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n/an/a 75.5n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q2RB76ZK
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200601
PNG
(US10011604, 27 | US10590139, Example 27 | US922797...)
Show SMILES NC(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C17H16F2N6O/c18-10-3-4-12(19)11(8-10)13-2-1-7-24(13)15-6-5-14-21-9-16(22-17(20)26)25(14)23-15/h3-6,8-9,13H,1-2,7H2,(H3,20,22,26)/t13-/m1/s1
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n/an/a 77.1n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q2RB76ZK
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200619
PNG
(US10011604, 45 | US10590139, Example 45 | US922797...)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccc2ncc(NC(=O)N3CC(F)(F)C3)n2n1
Show InChI InChI=1S/C20H18F4N6O/c21-12-3-4-14(22)13(8-12)15-2-1-7-29(15)17-6-5-16-25-9-18(30(16)27-17)26-19(31)28-10-20(23,24)11-28/h3-6,8-9,15H,1-2,7,10-11H2,(H,26,31)/t15-/m1/s1
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n/an/a 92n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q2RB76ZK
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200593
PNG
(US10011604, 20 | US10590139, Example 20 | US922797...)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccc2ncc(NC(=O)N3CCNCC3)n2n1
Show InChI InChI=1S/C21H23F2N7O/c22-14-3-4-16(23)15(12-14)17-2-1-9-29(17)19-6-5-18-25-13-20(30(18)27-19)26-21(31)28-10-7-24-8-11-28/h3-6,12-13,17,24H,1-2,7-11H2,(H,26,31)/t17-/m1/s1
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n/an/a 94.7n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q2RB76ZK
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200597
PNG
(US10011604, 24 | US10590139, Example 24 | US922797...)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccc2ncc(NC(=O)N3CC4CCC(C3)N4)n2n1
Show InChI InChI=1S/C23H25F2N7O/c24-14-3-6-18(25)17(10-14)19-2-1-9-31(19)21-8-7-20-26-11-22(32(20)29-21)28-23(33)30-12-15-4-5-16(13-30)27-15/h3,6-8,10-11,15-16,19,27H,1-2,4-5,9,12-13H2,(H,28,33)/t15?,16?,19-/m1/s1
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n/an/a 107n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q2RB76ZK
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200592
PNG
(US10011604, 19 | US10590139, Example 19 | US922797...)
Show SMILES NC1CN(C1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C20H21F2N7O/c21-12-3-4-15(22)14(8-12)16-2-1-7-28(16)18-6-5-17-24-9-19(29(17)26-18)25-20(30)27-10-13(23)11-27/h3-6,8-9,13,16H,1-2,7,10-11,23H2,(H,25,30)/t16-/m1/s1
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n/an/a 126n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q2RB76ZK
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200606
PNG
(US10011604, 32 | US10590139, Example 32 | US922797...)
Show SMILES COc1cc(NC(=O)Nc2cnc3ccc(nn23)N2CCC[C@@H]2c2cc(F)ccc2F)cc(OC)c1OC
Show InChI InChI=1S/C26H26F2N6O4/c1-36-20-12-16(13-21(37-2)25(20)38-3)30-26(35)31-24-14-29-22-8-9-23(32-34(22)24)33-10-4-5-19(33)17-11-15(27)6-7-18(17)28/h6-9,11-14,19H,4-5,10H2,1-3H3,(H2,30,31,35)/t19-/m1/s1
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n/an/a 176n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q2RB76ZK
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200617
PNG
(US10011604, 43 | US10590139, Example 43 | US922797...)
Show SMILES OC1CN(C1)C(=O)Nc1cnc2ccc(nn12)N1CCCCC1c1cccc(F)c1
Show InChI InChI=1S/C21H23FN6O2/c22-15-5-3-4-14(10-15)17-6-1-2-9-27(17)19-8-7-18-23-11-20(28(18)25-19)24-21(30)26-12-16(29)13-26/h3-5,7-8,10-11,16-17,29H,1-2,6,9,12-13H2,(H,24,30)
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n/an/a 216n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q2RB76ZK
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200580
PNG
(US10011604, 8 | US10590139, Example 8 | US9227975,...)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccc2ncc(NC(=O)Nc3cccc(c3)C(F)(F)F)n2n1
Show InChI InChI=1S/C24H19F5N6O/c25-15-6-7-18(26)17(12-15)19-5-2-10-34(19)21-9-8-20-30-13-22(35(20)33-21)32-23(36)31-16-4-1-3-14(11-16)24(27,28)29/h1,3-4,6-9,11-13,19H,2,5,10H2,(H2,31,32,36)/t19-/m1/s1
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n/an/a 508n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q2RB76ZK
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200581
PNG
(US10011604, 9 | US10590139, Example 9 | US9227975,...)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccc2ncc(NC(=O)Nc3cc(Cl)cc(Cl)c3)n2n1
Show InChI InChI=1S/C23H18Cl2F2N6O/c24-13-8-14(25)10-16(9-13)29-23(34)30-22-12-28-20-5-6-21(31-33(20)22)32-7-1-2-19(32)17-11-15(26)3-4-18(17)27/h3-6,8-12,19H,1-2,7H2,(H2,29,30,34)/t19-/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q2RB76ZK
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200623
PNG
(US10011604, 49 | US10590139, Example 49 | US922797...)
Show SMILES CC(C)[C@H]1CN(CCN1C(=O)OC(C)(C)C)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C29H37F2N7O3/c1-18(2)23-17-35(13-14-37(23)28(40)41-29(3,4)5)27(39)33-26-16-32-24-10-11-25(34-38(24)26)36-12-6-7-22(36)20-15-19(30)8-9-21(20)31/h8-11,15-16,18,22-23H,6-7,12-14,17H2,1-5H3,(H,33,39)/t22-,23-/m1/s1
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n/an/a 857n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q2RB76ZK
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200615
PNG
(US10011604, 41 | US10590139, Example 41 | US922797...)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccc2ncc(NC(=O)N3CCS(=O)(=O)CC3)n2n1
Show InChI InChI=1S/C21H22F2N6O3S/c22-14-3-4-16(23)15(12-14)17-2-1-7-28(17)19-6-5-18-24-13-20(29(18)26-19)25-21(30)27-8-10-33(31,32)11-9-27/h3-6,12-13,17H,1-2,7-11H2,(H,25,30)/t17-/m1/s1
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n/an/a 884n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q2RB76ZK
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200607
PNG
(US10011604, 33 | US10590139, Example 33 | US922797...)
Show SMILES Cc1noc(C)c1NC(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C22H21F2N7O2/c1-12-21(13(2)33-29-12)27-22(32)26-20-11-25-18-7-8-19(28-31(18)20)30-9-3-4-17(30)15-10-14(23)5-6-16(15)24/h5-8,10-11,17H,3-4,9H2,1-2H3,(H2,26,27,32)/t17-/m1/s1
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n/an/a 901n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q2RB76ZK
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%