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Patent code US10011607

Compile Data Set for Download or QSAR
Found 111 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402174
PNG
((9aRS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]...)
Show SMILES CC12CC(=O)N(C(=O)N1CCN(C2=O)c1ccncc1)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C27H20F2N4O3/c1-27-17-23(34)33(26(36)32(27)14-13-31(25(27)35)20-9-11-30-12-10-20)24-21(28)15-19(16-22(24)29)8-7-18-5-3-2-4-6-18/h2-6,9-12,15-16H,13-14,17H2,1H3
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US Patent
n/an/an/an/a 129n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402175
PNG
((9aS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]-...)
Show SMILES C[C@@]12CC(=O)N(C(=O)N1CCN(C2=O)c1ccncc1)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C27H20F2N4O3/c1-27-17-23(34)33(26(36)32(27)14-13-31(25(27)35)20-9-11-30-12-10-20)24-21(28)15-19(16-22(24)29)8-7-18-5-3-2-4-6-18/h2-6,9-12,15-16H,13-14,17H2,1H3/t27-/m0/s1
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n/an/an/an/a 29n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402178
PNG
((9aRS)-7-(2,6-difluoro-4- (phenylethynyl)phenyl)-9...)
Show SMILES Cc1ccnc(c1)N1CCN2C(=O)N(C(=O)CC2(C)C1=O)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C28H22F2N4O3/c1-18-10-11-31-23(14-18)32-12-13-33-27(37)34(24(35)17-28(33,2)26(32)36)25-21(29)15-20(16-22(25)30)9-8-19-6-4-3-5-7-19/h3-7,10-11,14-16H,12-13,17H2,1-2H3
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n/an/an/an/a 131n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402180
PNG
((9aRS)-7-(2,6-difluoro-4- (phenylethynyl)phenyl)-9...)
Show SMILES Cc1cncc(c1)N1CCN2C(=O)N(C(=O)CC2(C)C1=O)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C28H22F2N4O3/c1-18-12-21(17-31-16-18)32-10-11-33-27(37)34(24(35)15-28(33,2)26(32)36)25-22(29)13-20(14-23(25)30)9-8-19-6-4-3-5-7-19/h3-7,12-14,16-17H,10-11,15H2,1-2H3
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n/an/an/an/a 105n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402183
PNG
((9aS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]-...)
Show SMILES Cc1cncc(C)c1N1CCN2C(=O)N(C(=O)C[C@@]2(C)C1=O)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C29H24F2N4O3/c1-18-16-32-17-19(2)25(18)33-11-12-34-28(38)35(24(36)15-29(34,3)27(33)37)26-22(30)13-21(14-23(26)31)10-9-20-7-5-4-6-8-20/h4-8,13-14,16-17H,11-12,15H2,1-3H3/t29-/m0/s1
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n/an/an/an/a 201n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402184
PNG
((9aRS)-2-(2-chloro-4-pyridyl)- 7-[2,6-difluoro-4-(...)
Show SMILES CC12CC(=O)N(C(=O)N1CCN(C2=O)c1ccnc(Cl)c1)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C27H19ClF2N4O3/c1-27-16-23(35)34(24-20(29)13-18(14-21(24)30)8-7-17-5-3-2-4-6-17)26(37)33(27)12-11-32(25(27)36)19-9-10-31-22(28)15-19/h2-6,9-10,13-15H,11-12,16H2,1H3
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n/an/an/an/a 114n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402198
PNG
((9aS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]-...)
Show SMILES Cc1nccc(n1)N1CCN2C(=O)N(C(=O)C[C@@]2(C)C1=O)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C27H21F2N5O3/c1-17-30-11-10-22(31-17)32-12-13-33-26(37)34(23(35)16-27(33,2)25(32)36)24-20(28)14-19(15-21(24)29)9-8-18-6-4-3-5-7-18/h3-7,10-11,14-15H,12-13,16H2,1-2H3/t27-/m0/s1
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n/an/an/an/a 88n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402201
PNG
((9aRS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]...)
Show SMILES Cc1cncc(n1)N1CCN2C(=O)N(C(=O)CC2(C)C1=O)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C27H21F2N5O3/c1-17-15-30-16-22(31-17)32-10-11-33-26(37)34(23(35)14-27(33,2)25(32)36)24-20(28)12-19(13-21(24)29)9-8-18-6-4-3-5-7-18/h3-7,12-13,15-16H,10-11,14H2,1-2H3
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n/an/an/an/a 148n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402202
PNG
((9aS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]-...)
Show SMILES Cc1cc(ncn1)N1CCN2C(=O)N(C(=O)C[C@@]2(C)C1=O)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C27H21F2N5O3/c1-17-12-22(31-16-30-17)32-10-11-33-26(37)34(23(35)15-27(33,2)25(32)36)24-20(28)13-19(14-21(24)29)9-8-18-6-4-3-5-7-18/h3-7,12-14,16H,10-11,15H2,1-2H3/t27-/m0/s1
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n/an/an/an/a 91n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402210
PNG
((9aS)-2-(2-benzyloxypyrimidin- 5-yl)-7-[2,6-difluo...)
Show SMILES C[C@@]12CC(=O)N(C(=O)N1CCN(C2=O)c1cnc(OCc2ccccc2)nc1)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C33H25F2N5O4/c1-33-18-28(41)40(29-26(34)16-24(17-27(29)35)13-12-22-8-4-2-5-9-22)32(43)39(33)15-14-38(30(33)42)25-19-36-31(37-20-25)44-21-23-10-6-3-7-11-23/h2-11,16-17,19-20H,14-15,18,21H2,1H3/t33-/m0/s1
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n/an/an/an/a 81n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402211
PNG
((9aS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]-...)
Show SMILES C[C@@]12CC(=O)N(C(=O)N1CCN(C2=O)c1cnc(O)nc1)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C26H19F2N5O4/c1-26-13-21(34)33(22-19(27)11-17(12-20(22)28)8-7-16-5-3-2-4-6-16)25(37)32(26)10-9-31(23(26)35)18-14-29-24(36)30-15-18/h2-6,11-12,14-15H,9-10,13H2,1H3,(H,29,30,36)/t26-/m0/s1
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n/an/an/an/a 73n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402221
PNG
((9aS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]-...)
Show SMILES C[C@@]12CC(=O)N(C(=O)N1CCN(C2=O)c1ccnnc1)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C26H19F2N5O3/c1-26-15-22(34)33(25(36)32(26)12-11-31(24(26)35)19-9-10-29-30-16-19)23-20(27)13-18(14-21(23)28)8-7-17-5-3-2-4-6-17/h2-6,9-10,13-14,16H,11-12,15H2,1H3/t26-/m0/s1
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n/an/an/an/a 74n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402224
PNG
((9aRS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]...)
Show SMILES Cc1cnc(s1)N1CCN2C(=O)N(C(=O)CC2(C)C1=O)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C26H20F2N4O3S/c1-16-15-29-24(36-16)30-10-11-31-25(35)32(21(33)14-26(31,2)23(30)34)22-19(27)12-18(13-20(22)28)9-8-17-6-4-3-5-7-17/h3-7,12-13,15H,10-11,14H2,1-2H3
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n/an/an/an/a 88n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402231
PNG
((9aRS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]...)
Show SMILES Cc1cn(C)c(n1)N1CCN2C(=O)N(C(=O)CC2(C)C1=O)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C27H23F2N5O3/c1-17-16-31(3)25(30-17)32-11-12-33-26(37)34(22(35)15-27(33,2)24(32)36)23-20(28)13-19(14-21(23)29)10-9-18-7-5-4-6-8-18/h4-8,13-14,16H,11-12,15H2,1-3H3
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n/an/an/an/a 104n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402234
PNG
((9aRS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]...)
Show SMILES Cn1ccc(n1)N1CCN2C(=O)N(C(=O)CC2(C)C1=O)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C26H21F2N5O3/c1-26-16-22(34)33(25(36)32(26)13-12-31(24(26)35)21-10-11-30(2)29-21)23-19(27)14-18(15-20(23)28)9-8-17-6-4-3-5-7-17/h3-7,10-11,14-15H,12-13,16H2,1-2H3
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n/an/an/an/a 149n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402237
PNG
((9aS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]-...)
Show SMILES Cn1nccc1N1CCN2C(=O)N(C(=O)C[C@@]2(C)C1=O)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C26H21F2N5O3/c1-26-16-22(34)33(25(36)32(26)13-12-31(24(26)35)21-10-11-29-30(21)2)23-19(27)14-18(15-20(23)28)9-8-17-6-4-3-5-7-17/h3-7,10-11,14-15H,12-13,16H2,1-2H3/t26-/m0/s1
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n/an/an/an/a 92n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402248
PNG
((9aRS)-7-[2-chloro-6-fluoro-4-(2- phenylethynyl)ph...)
Show SMILES CC12CC(=O)N(C(=O)N1CCN(C2=O)c1ccccn1)c1c(F)cc(cc1Cl)C#Cc1ccccc1
Show InChI InChI=1S/C27H20ClFN4O3/c1-27-17-23(34)33(26(36)32(27)14-13-31(25(27)35)22-9-5-6-12-30-22)24-20(28)15-19(16-21(24)29)11-10-18-7-3-2-4-8-18/h2-9,12,15-16H,13-14,17H2,1H3
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n/an/an/an/a 128n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402250
PNG
((9aS)-7-[2-chloro-6-fluoro-4-(2- phenylethynyl)phe...)
Show SMILES Cn1cc(cn1)N1CCN2C(=O)N(C(=O)C[C@@]2(C)C1=O)c1c(F)cc(cc1Cl)C#Cc1ccccc1
Show InChI InChI=1S/C26H21ClFN5O3/c1-26-14-22(34)33(25(36)32(26)11-10-31(24(26)35)19-15-29-30(2)16-19)23-20(27)12-18(13-21(23)28)9-8-17-6-4-3-5-7-17/h3-7,12-13,15-16H,10-11,14H2,1-2H3/t26-/m0/s1
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n/an/an/an/a 75n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402279
PNG
((9aS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]-...)
Show SMILES CC[C@@]12CC(=O)N(C(=O)N1CCN(c1cnn(C)c1)C2=O)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C27H23F2N5O3/c1-3-27-15-23(35)34(26(37)33(27)12-11-32(25(27)36)20-16-30-31(2)17-20)24-21(28)13-19(14-22(24)29)10-9-18-7-5-4-6-8-18/h4-8,13-14,16-17H,3,11-12,15H2,1-2H3/t27-/m0/s1
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n/an/an/an/a 104n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402170
PNG
((9aRS)-7-(2,6-difluoro-4- (phenylethynyl)phenyl)-9...)
Show SMILES CC12CC(=O)N(C(=O)N1CCN(C2=O)c1ccccn1)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C27H20F2N4O3/c1-27-17-23(34)33(26(36)32(27)14-13-31(25(27)35)22-9-5-6-12-30-22)24-20(28)15-19(16-21(24)29)11-10-18-7-3-2-4-8-18/h2-9,12,15-16H,13-14,17H2,1H3
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n/an/an/an/a 119n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402181
PNG
((9aS)-7-(2,6-difluoro-4- (phenylethynyl)phenyl)-9a...)
Show SMILES Cc1cncc(c1)N1CCN2C(=O)N(C(=O)C[C@@]2(C)C1=O)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C28H22F2N4O3/c1-18-12-21(17-31-16-18)32-10-11-33-27(37)34(24(35)15-28(33,2)26(32)36)25-22(29)13-20(14-23(25)30)9-8-19-6-4-3-5-7-19/h3-7,12-14,16-17H,10-11,15H2,1-2H3/t28-/m0/s1
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n/an/an/an/a 152n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402182
PNG
((9aRS)-7-(2,6-difluoro-4- (phenylethynyl)phenyl)-9...)
Show SMILES Cc1ccc(cn1)N1CCN2C(=O)N(C(=O)CC2(C)C1=O)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C28H22F2N4O3/c1-18-8-11-21(17-31-18)32-12-13-33-27(37)34(24(35)16-28(33,2)26(32)36)25-22(29)14-20(15-23(25)30)10-9-19-6-4-3-5-7-19/h3-8,11,14-15,17H,12-13,16H2,1-2H3
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n/an/an/an/a 298n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402188
PNG
((9aRS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]...)
Show SMILES COc1ccc(cn1)N1CCN2C(=O)N(C(=O)CC2(C)C1=O)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C28H22F2N4O4/c1-28-16-24(35)34(25-21(29)14-19(15-22(25)30)9-8-18-6-4-3-5-7-18)27(37)33(28)13-12-32(26(28)36)20-10-11-23(38-2)31-17-20/h3-7,10-11,14-15,17H,12-13,16H2,1-2H3
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n/an/an/an/a 105n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402194
PNG
((9aS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]-...)
Show SMILES C[C@@]12CC(=O)N(C(=O)N1CCN(C2=O)c1ccncn1)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C26H19F2N5O3/c1-26-15-22(34)33(25(36)32(26)12-11-31(24(26)35)21-9-10-29-16-30-21)23-19(27)13-18(14-20(23)28)8-7-17-5-3-2-4-6-17/h2-6,9-10,13-14,16H,11-12,15H2,1H3/t26-/m0/s1
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n/an/an/an/a 39n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402199
PNG
((9aRS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]...)
Show SMILES CC12CC(=O)N(C(=O)N1CCN(C2=O)c1cnccn1)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C26H19F2N5O3/c1-26-15-22(34)33(25(36)32(26)12-11-31(24(26)35)21-16-29-9-10-30-21)23-19(27)13-18(14-20(23)28)8-7-17-5-3-2-4-6-17/h2-6,9-10,13-14,16H,11-12,15H2,1H3
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n/an/an/an/a 88n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402222
PNG
((9aRS)-7-(2,6-difluoro-4- (phenylethynyl)phenyl)-9...)
Show SMILES Cn1ncc(cc1=O)N1CCN2C(=O)N(C(=O)CC2(C)C1=O)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C27H21F2N5O4/c1-27-15-23(36)34(24-20(28)12-18(13-21(24)29)9-8-17-6-4-3-5-7-17)26(38)33(27)11-10-32(25(27)37)19-14-22(35)31(2)30-16-19/h3-7,12-14,16H,10-11,15H2,1-2H3
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n/an/an/an/a 191n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402227
PNG
((9aRS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]...)
Show SMILES CC12CC(=O)N(C(=O)N1CCN(c1nc(cs1)C(F)(F)F)C2=O)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C26H17F5N4O3S/c1-25-13-20(36)35(21-17(27)11-16(12-18(21)28)8-7-15-5-3-2-4-6-15)24(38)34(25)10-9-33(22(25)37)23-32-19(14-39-23)26(29,30)31/h2-6,11-12,14H,9-10,13H2,1H3
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n/an/an/an/a 166n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402239
PNG
((9aRS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]...)
Show SMILES Cn1cc(cn1)N1CCN2C(=O)N(C(=O)CC2(C)C1=O)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C26H21F2N5O3/c1-26-14-22(34)33(25(36)32(26)11-10-31(24(26)35)19-15-29-30(2)16-19)23-20(27)12-18(13-21(23)28)9-8-17-6-4-3-5-7-17/h3-7,12-13,15-16H,10-11,14H2,1-2H3
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n/an/an/an/a 113n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402244
PNG
((9aS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]-...)
Show SMILES COCCCn1cc(cn1)N1CCN2C(=O)N(C(=O)C[C@@]2(C)C1=O)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C29H27F2N5O4/c1-29-17-25(37)36(26-23(30)15-21(16-24(26)31)10-9-20-7-4-3-5-8-20)28(39)35(29)13-12-34(27(29)38)22-18-32-33(19-22)11-6-14-40-2/h3-5,7-8,15-16,18-19H,6,11-14,17H2,1-2H3/t29-/m0/s1
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n/an/an/an/a 122n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402247
PNG
((9aRS)-7-[2-chloro-6-fluoro-4-(2- phenylethynyl)ph...)
Show SMILES C[C@@]12CC(=O)N(C(=O)N1CCN(C2=O)c1ccncc1)c1c(F)cc(cc1Cl)C#Cc1ccccc1
Show InChI InChI=1S/C27H20ClFN4O3/c1-27-17-23(34)33(26(36)32(27)14-13-31(25(27)35)20-9-11-30-12-10-20)24-21(28)15-19(16-22(24)29)8-7-18-5-3-2-4-6-18/h2-6,9-12,15-16H,13-14,17H2,1H3/t27-/m0/s1
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n/an/an/an/a 210n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402251
PNG
((9aS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]-...)
Show SMILES COCCN1CCN2C(=O)N(C(=O)C[C@@]2(C)C1=O)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C25H23F2N3O4/c1-25-16-21(31)30(24(33)29(25)11-10-28(23(25)32)12-13-34-2)22-19(26)14-18(15-20(22)27)9-8-17-6-4-3-5-7-17/h3-7,14-15H,10-13,16H2,1-2H3/t25-/m0/s1
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n/an/an/an/a 137n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402260
PNG
((9aRS)-2-[(3-chloro- phenyl)methyl]- 7-[2,6-difluo...)
Show SMILES CC12CC(=O)N(C(=O)N1CCN(Cc1cccc(Cl)c1)C2=O)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C29H22ClF2N3O3/c1-29-17-25(36)35(26-23(31)15-20(16-24(26)32)11-10-19-6-3-2-4-7-19)28(38)34(29)13-12-33(27(29)37)18-21-8-5-9-22(30)14-21/h2-9,14-16H,12-13,17-18H2,1H3
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n/an/an/an/a 73n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402267
PNG
((9aRS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]...)
Show SMILES CC12CC(=O)N(C(=O)N1CCN(Cc1ccncn1)C2=O)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C27H21F2N5O3/c1-27-15-23(35)34(24-21(28)13-19(14-22(24)29)8-7-18-5-3-2-4-6-18)26(37)33(27)12-11-32(25(27)36)16-20-9-10-30-17-31-20/h2-6,9-10,13-14,17H,11-12,15-16H2,1H3
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n/an/an/an/a 142n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402273
PNG
((9aS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]-...)
Show SMILES Cn1cc(CCN2CCN3C(=O)N(C(=O)C[C@@]3(C)C2=O)c2c(F)cc(cc2F)C#Cc2ccccc2)cn1
Show InChI InChI=1S/C28H25F2N5O3/c1-28-16-24(36)35(25-22(29)14-20(15-23(25)30)9-8-19-6-4-3-5-7-19)27(38)34(28)13-12-33(26(28)37)11-10-21-17-31-32(2)18-21/h3-7,14-15,17-18H,10-13,16H2,1-2H3/t28-/m0/s1
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n/an/an/an/a 125n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402275
PNG
((9aR)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]-...)
Show SMILES COC[C@@]12CC(=O)N(C(=O)N1CCN(C2=O)c1cccnc1)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C28H22F2N4O4/c1-38-18-28-16-24(35)34(27(37)33(28)13-12-32(26(28)36)21-8-5-11-31-17-21)25-22(29)14-20(15-23(25)30)10-9-19-6-3-2-4-7-19/h2-8,11,14-15,17H,12-13,16,18H2,1H3/t28-/m1/s1
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n/an/an/an/a 169n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402281
PNG
((9aS)-7-[2,6-difluoro-4-[2-(2- fluorophenyl)ethyny...)
Show SMILES C[C@@]12CC(=O)N(C(=O)N1CCN(C2=O)c1cccnc1)c1c(F)cc(cc1F)C#Cc1ccccc1F
Show InChI InChI=1S/C27H19F3N4O3/c1-27-15-23(35)34(26(37)33(27)12-11-32(25(27)36)19-6-4-10-31-16-19)24-21(29)13-17(14-22(24)30)8-9-18-5-2-3-7-20(18)28/h2-7,10,13-14,16H,11-12,15H2,1H3/t27-/m0/s1
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n/an/an/an/a 56n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402166
PNG
((9aRS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]...)
Show SMILES Fc1cc(cc(F)c1N1C(=O)CC2N(CCN(C2=O)c2cccnc2)C1=O)C#Cc1ccccc1
Show InChI InChI=1S/C26H18F2N4O3/c27-20-13-18(9-8-17-5-2-1-3-6-17)14-21(28)24(20)32-23(33)15-22-25(34)30(11-12-31(22)26(32)35)19-7-4-10-29-16-19/h1-7,10,13-14,16,22H,11-12,15H2
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n/an/an/an/a 224n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402172
PNG
((9aRS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]...)
Show SMILES CC12CC(=O)N(C(=O)N1CCN(C2=O)c1cccnc1)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C27H20F2N4O3/c1-27-16-23(34)33(26(36)32(27)13-12-31(25(27)35)20-8-5-11-30-17-20)24-21(28)14-19(15-22(24)29)10-9-18-6-3-2-4-7-18/h2-8,11,14-15,17H,12-13,16H2,1H3
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n/an/an/an/a 118n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402173
PNG
((9aS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]-...)
Show SMILES C[C@@]12CC(=O)N(C(=O)N1CCN(C2=O)c1cccnc1)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C27H20F2N4O3/c1-27-16-23(34)33(26(36)32(27)13-12-31(25(27)35)20-8-5-11-30-17-20)24-21(28)14-19(15-22(24)29)10-9-18-6-3-2-4-7-18/h2-8,11,14-15,17H,12-13,16H2,1H3/t27-/m0/s1
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n/an/an/an/a 73n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402176
PNG
((9aRS)-7-(2,6-difluoro-4- (phenylethynyl)phenyl)-9...)
Show SMILES Cc1cccc(n1)N1CCN2C(=O)N(C(=O)CC2(C)C1=O)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C28H22F2N4O3/c1-18-7-6-10-23(31-18)32-13-14-33-27(37)34(24(35)17-28(33,2)26(32)36)25-21(29)15-20(16-22(25)30)12-11-19-8-4-3-5-9-19/h3-10,15-16H,13-14,17H2,1-2H3
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n/an/an/an/a 163n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402196
PNG
((9aRS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]...)
Show SMILES Cc1cc(nc(C)n1)N1CCN2C(=O)N(C(=O)CC2(C)C1=O)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C28H23F2N5O3/c1-17-13-23(32-18(2)31-17)33-11-12-34-27(38)35(24(36)16-28(34,3)26(33)37)25-21(29)14-20(15-22(25)30)10-9-19-7-5-4-6-8-19/h4-8,13-15H,11-12,16H2,1-3H3
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n/an/an/an/a 177n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402197
PNG
((9aRS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]...)
Show SMILES Cc1nccc(n1)N1CCN2C(=O)N(C(=O)CC2(C)C1=O)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C27H21F2N5O3/c1-17-30-11-10-22(31-17)32-12-13-33-26(37)34(23(35)16-27(33,2)25(32)36)24-20(28)14-19(15-21(24)29)9-8-18-6-4-3-5-7-18/h3-7,10-11,14-15H,12-13,16H2,1-2H3
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n/an/an/an/a 113n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402229
PNG
((9aRS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]...)
Show SMILES CC12CC(=O)N(C(=O)N1CCN(c1ncc(s1)C(F)(F)F)C2=O)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C26H17F5N4O3S/c1-25-13-20(36)35(21-17(27)11-16(12-18(21)28)8-7-15-5-3-2-4-6-15)24(38)34(25)10-9-33(22(25)37)23-32-14-19(39-23)26(29,30)31/h2-6,11-12,14H,9-10,13H2,1H3
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n/an/an/an/a 108n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402236
PNG
((9aRS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]...)
Show SMILES Cn1nccc1N1CCN2C(=O)N(C(=O)CC2(C)C1=O)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C26H21F2N5O3/c1-26-16-22(34)33(25(36)32(26)13-12-31(24(26)35)21-10-11-29-30(21)2)23-19(27)14-18(15-20(23)28)9-8-17-6-4-3-5-7-17/h3-7,10-11,14-15H,12-13,16H2,1-2H3
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n/an/an/an/a 125n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402249
PNG
((9aRS)-7-[2-chloro-6-fluoro-4-(2- phenylethynyl)ph...)
Show SMILES Cn1cc(cn1)N1CCN2C(=O)N(C(=O)CC2(C)C1=O)c1c(F)cc(cc1Cl)C#Cc1ccccc1
Show InChI InChI=1S/C26H21ClFN5O3/c1-26-14-22(34)33(25(36)32(26)11-10-31(24(26)35)19-15-29-30(2)16-19)23-20(27)12-18(13-21(23)28)9-8-17-6-4-3-5-7-17/h3-7,12-13,15-16H,10-11,14H2,1-2H3
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n/an/an/an/a 104n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402254
PNG
(Ethyl 4-[(9aS)-7-[2,6-difluoro- 4-(2-phenylethynyl...)
Show SMILES CCOC(=O)CCCN1CCN2C(=O)N(C(=O)C[C@@]2(C)C1=O)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C28H27F2N3O5/c1-3-38-24(35)10-7-13-31-14-15-32-27(37)33(23(34)18-28(32,2)26(31)36)25-21(29)16-20(17-22(25)30)12-11-19-8-5-4-6-9-19/h4-6,8-9,16-17H,3,7,10,13-15,18H2,1-2H3/t28-/m0/s1
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n/an/an/an/a 201n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402256
PNG
((9aRS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]...)
Show SMILES Cc1ccc(CN2CCN3C(=O)N(C(=O)CC3(C)C2=O)c2c(F)cc(cc2F)C#Cc2ccccc2)cc1
Show InChI InChI=1S/C30H25F2N3O3/c1-20-8-10-22(11-9-20)19-33-14-15-34-29(38)35(26(36)18-30(34,2)28(33)37)27-24(31)16-23(17-25(27)32)13-12-21-6-4-3-5-7-21/h3-11,16-17H,14-15,18-19H2,1-2H3
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n/an/an/an/a 117n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402262
PNG
((9aS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]-...)
Show SMILES C[C@@]12CC(=O)N(C(=O)N1CCN(Cc1cccc(F)c1)C2=O)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C29H22F3N3O3/c1-29-17-25(36)35(26-23(31)15-20(16-24(26)32)11-10-19-6-3-2-4-7-19)28(38)34(29)13-12-33(27(29)37)18-21-8-5-9-22(30)14-21/h2-9,14-16H,12-13,17-18H2,1H3/t29-/m0/s1
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n/an/an/an/a 187n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402266
PNG
((9aRS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]...)
Show SMILES CC12CC(=O)N(C(=O)N1CCN(Cc1ccncc1)C2=O)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C28H22F2N4O3/c1-28-17-24(35)34(25-22(29)15-21(16-23(25)30)8-7-19-5-3-2-4-6-19)27(37)33(28)14-13-32(26(28)36)18-20-9-11-31-12-10-20/h2-6,9-12,15-16H,13-14,17-18H2,1H3
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n/an/an/an/a 127n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402271
PNG
((9aS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]-...)
Show SMILES Cc1nccn1CCN1CCN2C(=O)N(C(=O)C[C@@]2(C)C1=O)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C28H25F2N5O3/c1-19-31-10-11-32(19)12-13-33-14-15-34-27(38)35(24(36)18-28(34,2)26(33)37)25-22(29)16-21(17-23(25)30)9-8-20-6-4-3-5-7-20/h3-7,10-11,16-17H,12-15,18H2,1-2H3/t28-/m0/s1
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n/an/an/an/a 282n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402171
PNG
((9aS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]-...)
Show SMILES C[C@@]12CC(=O)N(C(=O)N1CCN(C2=O)c1ccccn1)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C27H20F2N4O3/c1-27-17-23(34)33(26(36)32(27)14-13-31(25(27)35)22-9-5-6-12-30-22)24-20(28)15-19(16-21(24)29)11-10-18-7-3-2-4-8-18/h2-9,12,15-16H,13-14,17H2,1H3/t27-/m0/s1
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n/an/an/an/a 46n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402187
PNG
((9aS)-2-(6-chloro-3-pyridyl)- 7-[2,6-difluoro-4-(2...)
Show SMILES C[C@@]12CC(=O)N(C(=O)N1CCN(C2=O)c1ccc(Cl)nc1)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C27H19ClF2N4O3/c1-27-15-23(35)34(24-20(29)13-18(14-21(24)30)8-7-17-5-3-2-4-6-17)26(37)33(27)12-11-32(25(27)36)19-9-10-22(28)31-16-19/h2-6,9-10,13-14,16H,11-12,15H2,1H3/t27-/m0/s1
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n/an/an/an/a 73n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402189
PNG
((9aS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]-...)
Show SMILES COc1ccc(cn1)N1CCN2C(=O)N(C(=O)C[C@@]2(C)C1=O)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C28H22F2N4O4/c1-28-16-24(35)34(25-21(29)14-19(15-22(25)30)9-8-18-6-4-3-5-7-18)27(37)33(28)13-12-32(26(28)36)20-10-11-23(38-2)31-17-20/h3-7,10-11,14-15,17H,12-13,16H2,1-2H3/t28-/m0/s1
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n/an/an/an/a 61n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402191
PNG
((9aS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]-...)
Show SMILES Cn1cc(ccc1=O)N1CCN2C(=O)N(C(=O)C[C@@]2(C)C1=O)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C28H22F2N4O4/c1-28-16-24(36)34(25-21(29)14-19(15-22(25)30)9-8-18-6-4-3-5-7-18)27(38)33(28)13-12-32(26(28)37)20-10-11-23(35)31(2)17-20/h3-7,10-11,14-15,17H,12-13,16H2,1-2H3/t28-/m0/s1
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n/an/an/an/a 128n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402193
PNG
((9aRS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]...)
Show SMILES CC12CC(=O)N(C(=O)N1CCN(C2=O)c1ccncn1)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C26H19F2N5O3/c1-26-15-22(34)33(25(36)32(26)12-11-31(24(26)35)21-9-10-29-16-30-21)23-19(27)13-18(14-20(23)28)8-7-17-5-3-2-4-6-17/h2-6,9-10,13-14,16H,11-12,15H2,1H3
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n/an/an/an/a 36n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402200
PNG
((9aS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]-...)
Show SMILES C[C@@]12CC(=O)N(C(=O)N1CCN(C2=O)c1cnccn1)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C26H19F2N5O3/c1-26-15-22(34)33(25(36)32(26)12-11-31(24(26)35)21-16-29-9-10-30-21)23-19(27)13-18(14-20(23)28)8-7-17-5-3-2-4-6-17/h2-6,9-10,13-14,16H,11-12,15H2,1H3/t26-/m0/s1
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n/an/an/an/a 46n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402223
PNG
((9aRS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]...)
Show SMILES CC12CC(=O)N(C(=O)N1CCN(c1nccs1)C2=O)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C25H18F2N4O3S/c1-25-15-20(32)31(24(34)30(25)11-10-29(22(25)33)23-28-9-12-35-23)21-18(26)13-17(14-19(21)27)8-7-16-5-3-2-4-6-16/h2-6,9,12-14H,10-11,15H2,1H3
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n/an/an/an/a 113n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402263
PNG
((9aS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]-...)
Show SMILES C[C@@]12CC(=O)N(C(=O)N1CCN(Cc1ccc(F)cc1)C2=O)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C29H22F3N3O3/c1-29-17-25(36)35(26-23(31)15-21(16-24(26)32)8-7-19-5-3-2-4-6-19)28(38)34(29)14-13-33(27(29)37)18-20-9-11-22(30)12-10-20/h2-6,9-12,15-16H,13-14,17-18H2,1H3/t29-/m0/s1
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n/an/an/an/a 147n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402264
PNG
((9aRS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]...)
Show SMILES CC12CC(=O)N(C(=O)N1CCN(Cc1ccccn1)C2=O)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C28H22F2N4O3/c1-28-17-24(35)34(25-22(29)15-20(16-23(25)30)11-10-19-7-3-2-4-8-19)27(37)33(28)14-13-32(26(28)36)18-21-9-5-6-12-31-21/h2-9,12,15-16H,13-14,17-18H2,1H3
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n/an/an/an/a 198n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402272
PNG
((9aS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]-...)
Show SMILES Cn1nccc1CCN1CCN2C(=O)N(C(=O)C[C@@]2(C)C1=O)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C28H25F2N5O3/c1-28-18-24(36)35(25-22(29)16-20(17-23(25)30)9-8-19-6-4-3-5-7-19)27(38)34(28)15-14-33(26(28)37)13-11-21-10-12-31-32(21)2/h3-7,10,12,16-17H,11,13-15,18H2,1-2H3/t28-/m0/s1
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n/an/an/an/a 219n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402179
PNG
((9aS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]-...)
Show SMILES Cc1ccnc(c1)N1CCN2C(=O)N(C(=O)C[C@@]2(C)C1=O)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C28H22F2N4O3/c1-18-10-11-31-23(14-18)32-12-13-33-27(37)34(24(35)17-28(33,2)26(32)36)25-21(29)15-20(16-22(25)30)9-8-19-6-4-3-5-7-19/h3-7,10-11,14-16H,12-13,17H2,1-2H3/t28-/m0/s1
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n/an/an/an/a 131n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402192
PNG
((9aRS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]...)
Show SMILES CC12CC(=O)N(C(=O)N1CCN(C2=O)c1ncccn1)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C26H19F2N5O3/c1-26-16-21(34)33(25(36)32(26)13-12-31(23(26)35)24-29-10-5-11-30-24)22-19(27)14-18(15-20(22)28)9-8-17-6-3-2-4-7-17/h2-7,10-11,14-15H,12-13,16H2,1H3
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n/an/an/an/a 135n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402195
PNG
((9aRS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]...)
Show SMILES CC12CC(=O)N(C(=O)N1CCN(C2=O)c1cncnc1)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C26H19F2N5O3/c1-26-13-22(34)33(25(36)32(26)10-9-31(24(26)35)19-14-29-16-30-15-19)23-20(27)11-18(12-21(23)28)8-7-17-5-3-2-4-6-17/h2-6,11-12,14-16H,9-10,13H2,1H3
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n/an/an/an/a 145n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402204
PNG
((9aS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]-...)
Show SMILES COc1ncc(cn1)N1CCN2C(=O)N(C(=O)C[C@@]2(C)C1=O)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C27H21F2N5O4/c1-27-14-22(35)34(23-20(28)12-18(13-21(23)29)9-8-17-6-4-3-5-7-17)26(37)33(27)11-10-32(24(27)36)19-15-30-25(38-2)31-16-19/h3-7,12-13,15-16H,10-11,14H2,1-2H3/t27-/m0/s1
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n/an/an/an/a 55n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402208
PNG
((9aS or 9aR)-7-[2,6-difluoro-4-(2- phenylethynyl)p...)
Show SMILES CCOc1ncc(cn1)N1CCN2C(=O)N(C(=O)C[C@@]2(C)C1=O)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C28H23F2N5O4/c1-3-39-26-31-16-20(17-32-26)33-11-12-34-27(38)35(23(36)15-28(34,2)25(33)37)24-21(29)13-19(14-22(24)30)10-9-18-7-5-4-6-8-18/h4-8,13-14,16-17H,3,11-12,15H2,1-2H3/t28-/m0/s1
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n/an/an/an/a 96n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402214
PNG
((9aS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]-...)
Show SMILES COc1cnc(cn1)N1CCN2C(=O)N(C(=O)C[C@@]2(C)C1=O)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C27H21F2N5O4/c1-27-14-23(35)34(24-19(28)12-18(13-20(24)29)9-8-17-6-4-3-5-7-17)26(37)33(27)11-10-32(25(27)36)21-15-31-22(38-2)16-30-21/h3-7,12-13,15-16H,10-11,14H2,1-2H3/t27-/m0/s1
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n/an/an/an/a 123n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402215
PNG
((9aS)-2-(5-benzyloxypyrazin- 2-yl)-7-[2,6-difluoro...)
Show SMILES C[C@@]12CC(=O)N(C(=O)N1CCN(C2=O)c1cnc(OCc2ccccc2)cn1)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C33H25F2N5O4/c1-33-18-29(41)40(30-25(34)16-24(17-26(30)35)13-12-22-8-4-2-5-9-22)32(43)39(33)15-14-38(31(33)42)27-19-37-28(20-36-27)44-21-23-10-6-3-7-11-23/h2-11,16-17,19-20H,14-15,18,21H2,1H3/t33-/m0/s1
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n/an/an/an/a 190n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402232
PNG
((9aRS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]...)
Show SMILES Cc1nc(cn1C)N1CCN2C(=O)N(C(=O)CC2(C)C1=O)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C27H23F2N5O3/c1-17-30-22(16-31(17)3)32-11-12-33-26(37)34(23(35)15-27(33,2)25(32)36)24-20(28)13-19(14-21(24)29)10-9-18-7-5-4-6-8-18/h4-8,13-14,16H,11-12,15H2,1-3H3
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n/an/an/an/a 145n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402235
PNG
((9aS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]-...)
Show SMILES Cn1ccc(n1)N1CCN2C(=O)N(C(=O)C[C@@]2(C)C1=O)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C26H21F2N5O3/c1-26-16-22(34)33(25(36)32(26)13-12-31(24(26)35)21-10-11-30(2)29-21)23-19(27)14-18(15-20(23)28)9-8-17-6-4-3-5-7-17/h3-7,10-11,14-15H,12-13,16H2,1-2H3/t26-/m0/s1
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n/an/an/an/a 165n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402242
PNG
((9aS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]-...)
Show SMILES CC(C)n1cc(cn1)N1CCN2C(=O)N(C(=O)C[C@@]2(C)C1=O)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C28H25F2N5O3/c1-18(2)34-17-21(16-31-34)32-11-12-33-27(38)35(24(36)15-28(33,3)26(32)37)25-22(29)13-20(14-23(25)30)10-9-19-7-5-4-6-8-19/h4-8,13-14,16-18H,11-12,15H2,1-3H3/t28-/m0/s1
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n/an/an/an/a 139n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402243
PNG
((9aS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]-...)
Show SMILES C[C@@]12CC(=O)N(C(=O)N1CCN(c1cn[nH]c1)C2=O)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1/C25H19F2N5O3/c1-25-13-21(33)32(24(35)31(25)10-9-30(23(25)34)18-14-28-29-15-18)22-19(26)11-17(12-20(22)27)8-7-16-5-3-2-4-6-16/h2-6,11-12,14-15H,9-10,13H2,1H3,(H,28,29)/t25-/s2
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n/an/an/an/a 101n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402252
PNG
((9aS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]-...)
Show SMILES COCCCN1CCN2C(=O)N(C(=O)C[C@@]2(C)C1=O)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C26H25F2N3O4/c1-26-17-22(32)31(25(34)30(26)13-12-29(24(26)33)11-6-14-35-2)23-20(27)15-19(16-21(23)28)10-9-18-7-4-3-5-8-18/h3-5,7-8,15-16H,6,11-14,17H2,1-2H3/t26-/m0/s1
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n/an/an/an/a 135n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402274
PNG
((9aRS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]...)
Show SMILES COCC12CC(=O)N(C(=O)N1CCN(C2=O)c1cccnc1)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C28H22F2N4O4/c1-38-18-28-16-24(35)34(27(37)33(28)13-12-32(26(28)36)21-8-5-11-31-17-21)25-22(29)14-20(15-23(25)30)10-9-19-6-3-2-4-7-19/h2-8,11,14-15,17H,12-13,16,18H2,1H3
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n/an/an/an/a 129n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402282
PNG
((9aS)-7-[2,6-difluoro-4-[2-(2- fluorophenyl)ethyny...)
Show SMILES C[C@@]12CC(=O)N(C(=O)N1CCN(C2=O)c1ccncn1)c1c(F)cc(cc1F)C#Cc1ccccc1F
Show InChI InChI=1S/C26H18F3N5O3/c1-26-14-22(35)34(25(37)33(26)11-10-32(24(26)36)21-8-9-30-15-31-21)23-19(28)12-16(13-20(23)29)6-7-17-4-2-3-5-18(17)27/h2-5,8-9,12-13,15H,10-11,14H2,1H3/t26-/m0/s1
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n/an/an/an/a 31n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402186
PNG
((9aRS)-2-(6-chloro-3-pyridyl)- 7-[2,6-difluoro-4-(...)
Show SMILES CC12CC(=O)N(C(=O)N1CCN(C2=O)c1ccc(Cl)nc1)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C27H19ClF2N4O3/c1-27-15-23(35)34(24-20(29)13-18(14-21(24)30)8-7-17-5-3-2-4-6-17)26(37)33(27)12-11-32(25(27)36)19-9-10-22(28)31-16-19/h2-6,9-10,13-14,16H,11-12,15H2,1H3
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n/an/an/an/a 116n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402203
PNG
((9aS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]-...)
Show SMILES Cc1cncnc1N1CCN2C(=O)N(C(=O)C[C@@]2(C)C1=O)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C27H21F2N5O3/c1-17-15-30-16-31-24(17)32-10-11-33-26(37)34(22(35)14-27(33,2)25(32)36)23-20(28)12-19(13-21(23)29)9-8-18-6-4-3-5-7-18/h3-7,12-13,15-16H,10-11,14H2,1-2H3/t27-/m0/s1
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n/an/an/an/a 86n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402219
PNG
((9aS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]-...)
Show SMILES Cn1nc(ccc1=O)N1CCN2C(=O)N(C(=O)C[C@@]2(C)C1=O)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C27H21F2N5O4/c1-27-16-23(36)34(24-19(28)14-18(15-20(24)29)9-8-17-6-4-3-5-7-17)26(38)33(27)13-12-32(25(27)37)21-10-11-22(35)31(2)30-21/h3-7,10-11,14-15H,12-13,16H2,1-2H3/t27-/m0/s1
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n/an/an/an/a 197n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402233
PNG
((9aS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]-...)
Show SMILES Cc1nc(cn1CC(F)(F)F)N1CCN2C(=O)N(C(=O)C[C@@]2(C)C1=O)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C28H22F5N5O3/c1-17-34-22(15-35(17)16-28(31,32)33)36-10-11-37-26(41)38(23(39)14-27(37,2)25(36)40)24-20(29)12-19(13-21(24)30)9-8-18-6-4-3-5-7-18/h3-7,12-13,15H,10-11,14,16H2,1-2H3/t27-/m0/s1
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n/an/an/an/a 272n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402240
PNG
((9aS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]-...)
Show SMILES Cn1cc(cn1)N1CCN2C(=O)N(C(=O)C[C@@]2(C)C1=O)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C26H21F2N5O3/c1-26-14-22(34)33(25(36)32(26)11-10-31(24(26)35)19-15-29-30(2)16-19)23-20(27)12-18(13-21(23)28)9-8-17-6-4-3-5-7-17/h3-7,12-13,15-16H,10-11,14H2,1-2H3/t26-/m0/s1
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n/an/an/an/a 90n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402245
PNG
((9aS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]-...)
Show SMILES Cn1cnc(n1)N1CCN2C(=O)N(C(=O)C[C@@]2(C)C1=O)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C25H20F2N6O3/c1-25-14-20(34)33(24(36)32(25)11-10-31(22(25)35)23-28-15-30(2)29-23)21-18(26)12-17(13-19(21)27)9-8-16-6-4-3-5-7-16/h3-7,12-13,15H,10-11,14H2,1-2H3/t25-/m0/s1
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n/an/an/an/a 244n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402259
PNG
((9aRS)-2-[(2-chloro- phenyl)methyl]- 7-[2,6-difluo...)
Show SMILES CC12CC(=O)N(C(=O)N1CCN(Cc1ccccc1Cl)C2=O)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C29H22ClF2N3O3/c1-29-17-25(36)35(26-23(31)15-20(16-24(26)32)12-11-19-7-3-2-4-8-19)28(38)34(29)14-13-33(27(29)37)18-21-9-5-6-10-22(21)30/h2-10,15-16H,13-14,17-18H2,1H3
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n/an/an/an/a 87n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402261
PNG
((9aS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]-...)
Show SMILES C[C@@]12CC(=O)N(C(=O)N1CCN(Cc1ccccc1F)C2=O)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C29H22F3N3O3/c1-29-17-25(36)35(26-23(31)15-20(16-24(26)32)12-11-19-7-3-2-4-8-19)28(38)34(29)14-13-33(27(29)37)18-21-9-5-6-10-22(21)30/h2-10,15-16H,13-14,17-18H2,1H3/t29-/m0/s1
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n/an/an/an/a 149n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402268
PNG
((9aRS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]...)
Show SMILES Cn1cc(CN2CCN3C(=O)N(C(=O)CC3(C)C2=O)c2c(F)cc(cc2F)C#Cc2ccccc2)cn1
Show InChI InChI=1S/C27H23F2N5O3/c1-27-14-23(35)34(24-21(28)12-19(13-22(24)29)9-8-18-6-4-3-5-7-18)26(37)33(27)11-10-32(25(27)36)17-20-15-30-31(2)16-20/h3-7,12-13,15-16H,10-11,14,17H2,1-2H3
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n/an/an/an/a 214n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402177
PNG
((9aRS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]...)
Show SMILES Cc1cc(ccn1)N1CCN2C(=O)N(C(=O)CC2(C)C1=O)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C28H22F2N4O3/c1-18-14-21(10-11-31-18)32-12-13-33-27(37)34(24(35)17-28(33,2)26(32)36)25-22(29)15-20(16-23(25)30)9-8-19-6-4-3-5-7-19/h3-7,10-11,14-16H,12-13,17H2,1-2H3
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n/an/an/an/a 214n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402209
PNG
((9aS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]-...)
Show SMILES CC(C)Oc1ncc(cn1)N1CCN2C(=O)N(C(=O)C[C@@]2(C)C1=O)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C29H25F2N5O4/c1-18(2)40-27-32-16-21(17-33-27)34-11-12-35-28(39)36(24(37)15-29(35,3)26(34)38)25-22(30)13-20(14-23(25)31)10-9-19-7-5-4-6-8-19/h4-8,13-14,16-18H,11-12,15H2,1-3H3/t29-/m0/s1
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n/an/an/an/a 113n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402213
PNG
((9aS)-2-[2-(cyclopro- poxy)pyrimidin- 5-yl]-7-[2,6...)
Show SMILES C[C@@]12CC(=O)N(C(=O)N1CCN(C2=O)c1cnc(OC2CC2)nc1)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C29H23F2N5O4/c1-29-15-24(37)36(25-22(30)13-19(14-23(25)31)8-7-18-5-3-2-4-6-18)28(39)35(29)12-11-34(26(29)38)20-16-32-27(33-17-20)40-21-9-10-21/h2-6,13-14,16-17,21H,9-12,15H2,1H3/t29-/m0/s1
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n/an/an/an/a 171n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402216
PNG
((9aRS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]...)
Show SMILES CC12CC(=O)N(C(=O)N1CCN(C2=O)c1cccnn1)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C26H19F2N5O3/c1-26-16-22(34)33(25(36)32(26)13-12-31(24(26)35)21-8-5-11-29-30-21)23-19(27)14-18(15-20(23)28)10-9-17-6-3-2-4-7-17/h2-8,11,14-15H,12-13,16H2,1H3
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n/an/an/an/a 132n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402226
PNG
(2-[(9aRS)-7-[2,6-difluoro-4-(2- phenylethynyl)phen...)
Show SMILES CC12CC(=O)N(C(=O)N1CCN(c1nc(cs1)C#N)C2=O)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C26H17F2N5O3S/c1-26-13-21(34)33(22-19(27)11-17(12-20(22)28)8-7-16-5-3-2-4-6-16)25(36)32(26)10-9-31(23(26)35)24-30-18(14-29)15-37-24/h2-6,11-12,15H,9-10,13H2,1H3
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n/an/an/an/a 77n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402230
PNG
((9aRS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]...)
Show SMILES Cn1cnc(c1)N1CCN2C(=O)N(C(=O)CC2(C)C1=O)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C26H21F2N5O3/c1-26-14-22(34)33(25(36)32(26)11-10-31(24(26)35)21-15-30(2)16-29-21)23-19(27)12-18(13-20(23)28)9-8-17-6-4-3-5-7-17/h3-7,12-13,15-16H,10-11,14H2,1-2H3
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n/an/an/an/a 214n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402238
PNG
((9aRS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]...)
Show SMILES Cc1cc(N2CCN3C(=O)N(C(=O)CC3(C)C2=O)c2c(F)cc(cc2F)C#Cc2ccccc2)n(C)n1
Show InChI InChI=1S/C27H23F2N5O3/c1-17-13-22(31(3)30-17)32-11-12-33-26(37)34(23(35)16-27(33,2)25(32)36)24-20(28)14-19(15-21(24)29)10-9-18-7-5-4-6-8-18/h4-8,13-15H,11-12,16H2,1-3H3
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n/an/an/an/a 85n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402246
PNG
((9aRS)-7-[2-chloro-6-fluoro-4-(2- phenylethynyl)ph...)
Show SMILES CC12CC(=O)N(C(=O)N1CCN(C2=O)c1cccnc1)c1c(F)cc(cc1Cl)C#Cc1ccccc1
Show InChI InChI=1S/C27H20ClFN4O3/c1-27-16-23(34)33(26(36)32(27)13-12-31(25(27)35)20-8-5-11-30-17-20)24-21(28)14-19(15-22(24)29)10-9-18-6-3-2-4-7-18/h2-8,11,14-15,17H,12-13,16H2,1H3
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n/an/an/an/a 102n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402258
PNG
((9aRS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]...)
Show SMILES Cc1cccc(C)c1CN1CCN2C(=O)N(C(=O)CC2(C)C1=O)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C31H27F2N3O3/c1-20-8-7-9-21(2)24(20)19-34-14-15-35-30(39)36(27(37)18-31(35,3)29(34)38)28-25(32)16-23(17-26(28)33)13-12-22-10-5-4-6-11-22/h4-11,16-17H,14-15,18-19H2,1-3H3
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n/an/an/an/a 68n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402265
PNG
((9aRS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]...)
Show SMILES CC12CC(=O)N(C(=O)N1CCN(Cc1cccnc1)C2=O)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C28H22F2N4O3/c1-28-16-24(35)34(25-22(29)14-20(15-23(25)30)10-9-19-6-3-2-4-7-19)27(37)33(28)13-12-32(26(28)36)18-21-8-5-11-31-17-21/h2-8,11,14-15,17H,12-13,16,18H2,1H3
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n/an/an/an/a 217n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402276
PNG
((9aRS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]...)
Show SMILES COCC12CC(=O)N(C(=O)N1CCN(c1cnn(C)c1)C2=O)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C27H23F2N5O4/c1-31-16-20(15-30-31)32-10-11-33-26(37)34(23(35)14-27(33,17-38-2)25(32)36)24-21(28)12-19(13-22(24)29)9-8-18-6-4-3-5-7-18/h3-7,12-13,15-16H,10-11,14,17H2,1-2H3
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n/an/an/an/a 273n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402277
PNG
((9aR)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]-...)
Show SMILES COC[C@@]12CC(=O)N(C(=O)N1CCN(c1cnn(C)c1)C2=O)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C27H23F2N5O4/c1-31-16-20(15-30-31)32-10-11-33-26(37)34(23(35)14-27(33,17-38-2)25(32)36)24-21(28)12-19(13-22(24)29)9-8-18-6-4-3-5-7-18/h3-7,12-13,15-16H,10-11,14,17H2,1-2H3/t27-/m1/s1
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n/an/an/an/a 61n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402280
PNG
((9aRS)-7-[2-fluoro-4-(2- phenylethynyl)phenyl]-9a-...)
Show SMILES CC12CC(=O)N(C(=O)N1CCN(C2=O)c1cccnc1)c1ccc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C27H21FN4O3/c1-27-17-24(33)32(23-12-11-20(16-22(23)28)10-9-19-6-3-2-4-7-19)26(35)31(27)15-14-30(25(27)34)21-8-5-13-29-18-21/h2-8,11-13,16,18H,14-15,17H2,1H3
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n/an/an/an/a 267n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402283
PNG
((9aS)-7-[2,6-difluoro-4-[2-(2- fluorophenyl)ethyny...)
Show SMILES Cn1cc(cn1)N1CCN2C(=O)N(C(=O)C[C@@]2(C)C1=O)c1c(F)cc(cc1F)C#Cc1ccccc1F
Show InChI InChI=1S/C26H20F3N5O3/c1-26-13-22(35)34(25(37)33(26)10-9-32(24(26)36)18-14-30-31(2)15-18)23-20(28)11-16(12-21(23)29)7-8-17-5-3-4-6-19(17)27/h3-6,11-12,14-15H,9-10,13H2,1-2H3/t26-/m0/s1
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n/an/an/an/a 56n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402168
PNG
((9aRS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]...)
Show SMILES Fc1cc(cc(F)c1N1C(=O)CC2N(CCN(C2=O)c2ccncn2)C1=O)C#Cc1ccccc1
Show InChI InChI=1S/C25H17F2N5O3/c26-18-12-17(7-6-16-4-2-1-3-5-16)13-19(27)23(18)32-22(33)14-20-24(34)31(11-10-30(20)25(32)35)21-8-9-28-15-29-21/h1-5,8-9,12-13,15,20H,10-11,14H2
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n/an/an/an/a 85n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402169
PNG
((9aRS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]...)
Show SMILES Fc1cc(cc(F)c1N1C(=O)CC2N(CCN(C2=O)c2ccccn2)C1=O)C#Cc1ccccc1
Show InChI InChI=1S/C26H18F2N4O3/c27-19-14-18(10-9-17-6-2-1-3-7-17)15-20(28)24(19)32-23(33)16-21-25(34)31(13-12-30(21)26(32)35)22-8-4-5-11-29-22/h1-8,11,14-15,21H,12-13,16H2
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n/an/an/an/a 235n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402185
PNG
((9aS)-2-(2-chloro-4-pyridyl)- 7-[2,6-difluoro-4-(2...)
Show SMILES C[C@@]12CC(=O)N(C(=O)N1CCN(C2=O)c1ccnc(Cl)c1)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C27H19ClF2N4O3/c1-27-16-23(35)34(24-20(29)13-18(14-21(24)30)8-7-17-5-3-2-4-6-17)26(37)33(27)12-11-32(25(27)36)19-9-10-31-22(28)15-19/h2-6,9-10,13-15H,11-12,16H2,1H3/t27-/m0/s1
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n/an/an/an/a 69n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402207
PNG
((9aS)-2-(2-tert-butoxypyrimidin- 5-yl)-7-[2,6-difl...)
Show SMILES CC(C)(C)Oc1ncc(cn1)N1CCN2C(=O)N(C(=O)C[C@@]2(C)C1=O)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C30H27F2N5O4/c1-29(2,3)41-27-33-17-21(18-34-27)35-12-13-36-28(40)37(24(38)16-30(36,4)26(35)39)25-22(31)14-20(15-23(25)32)11-10-19-8-6-5-7-9-19/h5-9,14-15,17-18H,12-13,16H2,1-4H3/t30-/m0/s1
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n/an/an/an/a 157n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402217
PNG
((9aS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]-...)
Show SMILES C[C@@]12CC(=O)N(C(=O)N1CCN(C2=O)c1cccnn1)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C26H19F2N5O3/c1-26-16-22(34)33(25(36)32(26)13-12-31(24(26)35)21-8-5-11-29-30-21)23-19(27)14-18(15-20(23)28)10-9-17-6-3-2-4-7-17/h2-8,11,14-15H,12-13,16H2,1H3/t26-/m0/s1
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n/an/an/an/a 55n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402218
PNG
((9aRS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]...)
Show SMILES Cc1ccc(nn1)N1CCN2C(=O)N(C(=O)CC2(C)C1=O)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C27H21F2N5O3/c1-17-8-11-22(31-30-17)32-12-13-33-26(37)34(23(35)16-27(33,2)25(32)36)24-20(28)14-19(15-21(24)29)10-9-18-6-4-3-5-7-18/h3-8,11,14-15H,12-13,16H2,1-2H3
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US Patent
n/an/an/an/a 198n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402225
PNG
((9aRS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]...)
Show SMILES Cc1csc(n1)N1CCN2C(=O)N(C(=O)CC2(C)C1=O)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C26H20F2N4O3S/c1-16-15-36-24(29-16)30-10-11-31-25(35)32(21(33)14-26(31,2)23(30)34)22-19(27)12-18(13-20(22)28)9-8-17-6-4-3-5-7-17/h3-7,12-13,15H,10-11,14H2,1-2H3
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US Patent
n/an/an/an/a 48n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402241
PNG
((9aS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]-...)
Show SMILES CCn1cc(cn1)N1CCN2C(=O)N(C(=O)C[C@@]2(C)C1=O)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C27H23F2N5O3/c1-3-31-17-20(16-30-31)32-11-12-33-26(37)34(23(35)15-27(33,2)25(32)36)24-21(28)13-19(14-22(24)29)10-9-18-7-5-4-6-8-18/h4-8,13-14,16-17H,3,11-12,15H2,1-2H3/t27-/m0/s1
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n/an/an/an/a 151n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402253
PNG
((9aS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]-...)
Show SMILES C[C@@]12CC(=O)N(C(=O)N1CCN(CC(F)(F)F)C2=O)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C24H18F5N3O3/c1-23-13-19(33)32(22(35)31(23)10-9-30(21(23)34)14-24(27,28)29)20-17(25)11-16(12-18(20)26)8-7-15-5-3-2-4-6-15/h2-6,11-12H,9-10,13-14H2,1H3/t23-/m0/s1
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n/an/an/an/a 112n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402255
PNG
((9aRS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]...)
Show SMILES Cc1cccc(CN2CCN3C(=O)N(C(=O)CC3(C)C2=O)c2c(F)cc(cc2F)C#Cc2ccccc2)c1
Show InChI InChI=1S/C30H25F2N3O3/c1-20-7-6-10-23(15-20)19-33-13-14-34-29(38)35(26(36)18-30(34,2)28(33)37)27-24(31)16-22(17-25(27)32)12-11-21-8-4-3-5-9-21/h3-10,15-17H,13-14,18-19H2,1-2H3
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US Patent
n/an/an/an/a 173n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402257
PNG
((9aRS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]...)
Show SMILES Cc1ccccc1CN1CCN2C(=O)N(C(=O)CC2(C)C1=O)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C30H25F2N3O3/c1-20-8-6-7-11-23(20)19-33-14-15-34-29(38)35(26(36)18-30(34,2)28(33)37)27-24(31)16-22(17-25(27)32)13-12-21-9-4-3-5-10-21/h3-11,16-17H,14-15,18-19H2,1-2H3
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n/an/an/an/a 205n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402269
PNG
((9aS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]-...)
Show SMILES Cn1nccc1CN1CCN2C(=O)N(C(=O)C[C@@]2(C)C1=O)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C27H23F2N5O3/c1-27-16-23(35)34(24-21(28)14-19(15-22(24)29)9-8-18-6-4-3-5-7-18)26(37)33(27)13-12-32(25(27)36)17-20-10-11-30-31(20)2/h3-7,10-11,14-15H,12-13,16-17H2,1-2H3/t27-/m0/s1
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n/an/an/an/a 76n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402270
PNG
((9aS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]-...)
Show SMILES C[C@@]12CC(=O)N(C(=O)N1CCN(CCn1ccnc1)C2=O)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C27H23F2N5O3/c1-27-17-23(35)34(24-21(28)15-20(16-22(24)29)8-7-19-5-3-2-4-6-19)26(37)33(27)14-13-32(25(27)36)12-11-31-10-9-30-18-31/h2-6,9-10,15-16,18H,11-14,17H2,1H3/t27-/m0/s1
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n/an/an/an/a 283n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM402278
PNG
((9aS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]-...)
Show SMILES CC[C@@]12CC(=O)N(C(=O)N1CCN(C2=O)c1cccnc1)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C28H22F2N4O3/c1-2-28-17-24(35)34(27(37)33(28)14-13-32(26(28)36)21-9-6-12-31-18-21)25-22(29)15-20(16-23(25)30)11-10-19-7-4-3-5-8-19/h3-9,12,15-16,18H,2,13-14,17H2,1H3/t28-/m0/s1
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n/an/an/an/a 95n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US10011607 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%