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Patent code US10011627

Compile Data Set for Download or QSAR
Found 18 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM402285
PNG
(US10011627, 1)
Show SMILES OC[C@@]12CO[C@@](O1)([C@H](O)[C@@H](O)[C@@H]2O)c1ccc(Cl)c(Cc2ccc3OCCOc3c2)c1
Show InChI InChI=1S/C22H23ClO8/c23-15-3-2-14(22-20(27)18(25)19(26)21(10-24,31-22)11-30-22)9-13(15)7-12-1-4-16-17(8-12)29-6-5-28-16/h1-4,8-9,18-20,24-27H,5-7,10-11H2/t18-,19-,20+,21-,22-/m0/s1
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.580n/an/an/an/an/an/a



YOUNGENE THERAPEUTICS CO., LTD

US Patent


Assay Description
The following method was used to determine the inhibitory activity of the compounds of the present invention on SGLT1 and SGLT2. The experimental met...


US Patent US10011627 (2018)

More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM402292
PNG
(US10011627, 8)
Show SMILES Cc1ccc(cc1Cc1ccc2OCCOc2c1)[C@]12OC[C@](CO)(O1)[C@@H](O)[C@H](O)[C@H]2O
Show InChI InChI=1S/C23H26O8/c1-13-2-4-16(23-21(27)19(25)20(26)22(11-24,31-23)12-30-23)10-15(13)8-14-3-5-17-18(9-14)29-7-6-28-17/h2-5,9-10,19-21,24-27H,6-8,11-12H2,1H3/t19-,20-,21+,22-,23-/m0/s1
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.21n/an/an/an/an/an/a



YOUNGENE THERAPEUTICS CO., LTD

US Patent


Assay Description
The following method was used to determine the inhibitory activity of the compounds of the present invention on SGLT1 and SGLT2. The experimental met...


US Patent US10011627 (2018)

More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM402293
PNG
(US10011627, 9)
Show SMILES CCc1ccc(cc1Cc1ccc2OCCOc2c1)[C@]12OC[C@](CO)(O1)[C@@H](O)[C@H](O)[C@H]2O
Show InChI InChI=1S/C24H28O8/c1-2-15-4-5-17(24-22(28)20(26)21(27)23(12-25,32-24)13-31-24)11-16(15)9-14-3-6-18-19(10-14)30-8-7-29-18/h3-6,10-11,20-22,25-28H,2,7-9,12-13H2,1H3/t20-,21-,22+,23-,24-/m0/s1
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.49n/an/an/an/an/an/a



YOUNGENE THERAPEUTICS CO., LTD

US Patent


Assay Description
The following method was used to determine the inhibitory activity of the compounds of the present invention on SGLT1 and SGLT2. The experimental met...


US Patent US10011627 (2018)

More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM402291
PNG
(US10011627, 7)
Show SMILES CCCc1ccc(cc1Cc1ccc2OCCOc2c1)[C@]12OC[C@](CO)(O1)[C@@H](O)[C@H](O)[C@H]2O
Show InChI InChI=1S/C25H30O8/c1-2-3-16-5-6-18(25-23(29)21(27)22(28)24(13-26,33-25)14-32-25)12-17(16)10-15-4-7-19-20(11-15)31-9-8-30-19/h4-7,11-12,21-23,26-29H,2-3,8-10,13-14H2,1H3/t21-,22-,23+,24-,25-/m0/s1
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.82n/an/an/an/an/an/a



YOUNGENE THERAPEUTICS CO., LTD

US Patent


Assay Description
The following method was used to determine the inhibitory activity of the compounds of the present invention on SGLT1 and SGLT2. The experimental met...


US Patent US10011627 (2018)

More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM402290
PNG
(US10011627, 6)
Show SMILES Cc1cc(O)c(cc1Cc1ccc2OCCOc2c1)[C@@H]1S[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1S/C22H26O7S/c1-11-6-15(24)14(22-21(27)20(26)19(25)18(10-23)30-22)9-13(11)7-12-2-3-16-17(8-12)29-5-4-28-16/h2-3,6,8-9,18-27H,4-5,7,10H2,1H3/t18-,19-,20+,21-,22+/m1/s1
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.59n/an/an/an/an/an/a



YOUNGENE THERAPEUTICS CO., LTD

US Patent


Assay Description
The following method was used to determine the inhibitory activity of the compounds of the present invention on SGLT1 and SGLT2. The experimental met...


US Patent US10011627 (2018)

More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM402286
PNG
(US10011627, 2)
Show SMILES OC[C@@]12CO[C@@](O1)([C@H](O)[C@@H](O)[C@@H]2O)c1ccc(C2CC2)c(Cc2ccc3OCCOc3c2)c1
Show InChI InChI=1S/C25H28O8/c26-12-24-13-32-25(33-24,23(29)21(27)22(24)28)17-4-5-18(15-2-3-15)16(11-17)9-14-1-6-19-20(10-14)31-8-7-30-19/h1,4-6,10-11,15,21-23,26-29H,2-3,7-9,12-13H2/t21-,22-,23+,24-,25-/m0/s1
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.67n/an/an/an/an/an/a



YOUNGENE THERAPEUTICS CO., LTD

US Patent


Assay Description
The following method was used to determine the inhibitory activity of the compounds of the present invention on SGLT1 and SGLT2. The experimental met...


US Patent US10011627 (2018)

More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM402289
PNG
(US10011627, 5)
Show SMILES OC[C@H]1S[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C2CC2)c(Cc2ccc3OCCOc3c2)c1
Show InChI InChI=1S/C24H28O6S/c25-12-20-21(26)22(27)23(28)24(31-20)15-4-5-17(14-2-3-14)16(11-15)9-13-1-6-18-19(10-13)30-8-7-29-18/h1,4-6,10-11,14,20-28H,2-3,7-9,12H2/t20-,21-,22+,23-,24+/m1/s1
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4.30n/an/an/an/an/an/a



YOUNGENE THERAPEUTICS CO., LTD

US Patent


Assay Description
The following method was used to determine the inhibitory activity of the compounds of the present invention on SGLT1 and SGLT2. The experimental met...


US Patent US10011627 (2018)

More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM402286
PNG
(US10011627, 2)
Show SMILES OC[C@@]12CO[C@@](O1)([C@H](O)[C@@H](O)[C@@H]2O)c1ccc(C2CC2)c(Cc2ccc3OCCOc3c2)c1
Show InChI InChI=1S/C25H28O8/c26-12-24-13-32-25(33-24,23(29)21(27)22(24)28)17-4-5-18(15-2-3-15)16(11-17)9-14-1-6-19-20(10-14)31-8-7-30-19/h1,4-6,10-11,15,21-23,26-29H,2-3,7-9,12-13H2/t21-,22-,23+,24-,25-/m0/s1
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 15.7n/an/an/an/an/an/a



YOUNGENE THERAPEUTICS CO., LTD

US Patent


Assay Description
The following method was used to determine the inhibitory activity of the compounds of the present invention on SGLT1 and SGLT2. The experimental met...


US Patent US10011627 (2018)

More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM402293
PNG
(US10011627, 9)
Show SMILES CCc1ccc(cc1Cc1ccc2OCCOc2c1)[C@]12OC[C@](CO)(O1)[C@@H](O)[C@H](O)[C@H]2O
Show InChI InChI=1S/C24H28O8/c1-2-15-4-5-17(24-22(28)20(26)21(27)23(12-25,32-24)13-31-24)11-16(15)9-14-3-6-18-19(10-14)30-8-7-29-18/h3-6,10-11,20-22,25-28H,2,7-9,12-13H2,1H3/t20-,21-,22+,23-,24-/m0/s1
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 16.6n/an/an/an/an/an/a



YOUNGENE THERAPEUTICS CO., LTD

US Patent


Assay Description
The following method was used to determine the inhibitory activity of the compounds of the present invention on SGLT1 and SGLT2. The experimental met...


US Patent US10011627 (2018)

More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM402291
PNG
(US10011627, 7)
Show SMILES CCCc1ccc(cc1Cc1ccc2OCCOc2c1)[C@]12OC[C@](CO)(O1)[C@@H](O)[C@H](O)[C@H]2O
Show InChI InChI=1S/C25H30O8/c1-2-3-16-5-6-18(25-23(29)21(27)22(28)24(13-26,33-25)14-32-25)12-17(16)10-15-4-7-19-20(11-15)31-9-8-30-19/h4-7,11-12,21-23,26-29H,2-3,8-10,13-14H2,1H3/t21-,22-,23+,24-,25-/m0/s1
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 17.2n/an/an/an/an/an/a



YOUNGENE THERAPEUTICS CO., LTD

US Patent


Assay Description
The following method was used to determine the inhibitory activity of the compounds of the present invention on SGLT1 and SGLT2. The experimental met...


US Patent US10011627 (2018)

More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM402287
PNG
(US10011627, 3)
Show SMILES OC[C@H]1S[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1cc2CCOc2c(Cc2ccc3OCCOc3c2)c1
Show InChI InChI=1S/C23H26O7S/c24-11-18-19(25)20(26)21(27)23(31-18)15-9-13-3-4-30-22(13)14(10-15)7-12-1-2-16-17(8-12)29-6-5-28-16/h1-2,8-10,18-21,23-27H,3-7,11H2/t18-,19-,20+,21-,23+/m1/s1
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 19.8n/an/an/an/an/an/a



YOUNGENE THERAPEUTICS CO., LTD

US Patent


Assay Description
The following method was used to determine the inhibitory activity of the compounds of the present invention on SGLT1 and SGLT2. The experimental met...


US Patent US10011627 (2018)

More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM402288
PNG
(US10011627, 4)
Show SMILES Cc1ccc(cc1Cc1ccc2OCCOc2c1)[C@@H]1S[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1S/C22H26O6S/c1-12-2-4-14(22-21(26)20(25)19(24)18(11-23)29-22)10-15(12)8-13-3-5-16-17(9-13)28-7-6-27-16/h2-5,9-10,18-26H,6-8,11H2,1H3/t18-,19-,20+,21-,22+/m1/s1
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 89n/an/an/an/an/an/a



YOUNGENE THERAPEUTICS CO., LTD

US Patent


Assay Description
The following method was used to determine the inhibitory activity of the compounds of the present invention on SGLT1 and SGLT2. The experimental met...


US Patent US10011627 (2018)

More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM402290
PNG
(US10011627, 6)
Show SMILES Cc1cc(O)c(cc1Cc1ccc2OCCOc2c1)[C@@H]1S[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1S/C22H26O7S/c1-11-6-15(24)14(22-21(27)20(26)19(25)18(10-23)30-22)9-13(11)7-12-2-3-16-17(8-12)29-5-4-28-16/h2-3,6,8-9,18-27H,4-5,7,10H2,1H3/t18-,19-,20+,21-,22+/m1/s1
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 99.9n/an/an/an/an/an/a



YOUNGENE THERAPEUTICS CO., LTD

US Patent


Assay Description
The following method was used to determine the inhibitory activity of the compounds of the present invention on SGLT1 and SGLT2. The experimental met...


US Patent US10011627 (2018)

More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM402288
PNG
(US10011627, 4)
Show SMILES Cc1ccc(cc1Cc1ccc2OCCOc2c1)[C@@H]1S[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1S/C22H26O6S/c1-12-2-4-14(22-21(26)20(25)19(24)18(11-23)29-22)10-15(12)8-13-3-5-16-17(9-13)28-7-6-27-16/h2-5,9-10,18-26H,6-8,11H2,1H3/t18-,19-,20+,21-,22+/m1/s1
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 132n/an/an/an/an/an/a



YOUNGENE THERAPEUTICS CO., LTD

US Patent


Assay Description
The following method was used to determine the inhibitory activity of the compounds of the present invention on SGLT1 and SGLT2. The experimental met...


US Patent US10011627 (2018)

More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM402289
PNG
(US10011627, 5)
Show SMILES OC[C@H]1S[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C2CC2)c(Cc2ccc3OCCOc3c2)c1
Show InChI InChI=1S/C24H28O6S/c25-12-20-21(26)22(27)23(28)24(31-20)15-4-5-17(14-2-3-14)16(11-15)9-13-1-6-18-19(10-13)30-8-7-29-18/h1,4-6,10-11,14,20-28H,2-3,7-9,12H2/t20-,21-,22+,23-,24+/m1/s1
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 301n/an/an/an/an/an/a



YOUNGENE THERAPEUTICS CO., LTD

US Patent


Assay Description
The following method was used to determine the inhibitory activity of the compounds of the present invention on SGLT1 and SGLT2. The experimental met...


US Patent US10011627 (2018)

More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM402292
PNG
(US10011627, 8)
Show SMILES Cc1ccc(cc1Cc1ccc2OCCOc2c1)[C@]12OC[C@](CO)(O1)[C@@H](O)[C@H](O)[C@H]2O
Show InChI InChI=1S/C23H26O8/c1-13-2-4-16(23-21(27)19(25)20(26)22(11-24,31-23)12-30-23)10-15(13)8-14-3-5-17-18(9-14)29-7-6-28-17/h2-5,9-10,19-21,24-27H,6-8,11-12H2,1H3/t19-,20-,21+,22-,23-/m0/s1
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 583n/an/an/an/an/an/a



YOUNGENE THERAPEUTICS CO., LTD

US Patent


Assay Description
The following method was used to determine the inhibitory activity of the compounds of the present invention on SGLT1 and SGLT2. The experimental met...


US Patent US10011627 (2018)

More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM402285
PNG
(US10011627, 1)
Show SMILES OC[C@@]12CO[C@@](O1)([C@H](O)[C@@H](O)[C@@H]2O)c1ccc(Cl)c(Cc2ccc3OCCOc3c2)c1
Show InChI InChI=1S/C22H23ClO8/c23-15-3-2-14(22-20(27)18(25)19(26)21(10-24,31-22)11-30-22)9-13(15)7-12-1-4-16-17(8-12)29-6-5-28-16/h1-4,8-9,18-20,24-27H,5-7,10-11H2/t18-,19-,20+,21-,22-/m0/s1
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 953n/an/an/an/an/an/a



YOUNGENE THERAPEUTICS CO., LTD

US Patent


Assay Description
The following method was used to determine the inhibitory activity of the compounds of the present invention on SGLT1 and SGLT2. The experimental met...


US Patent US10011627 (2018)

More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM402287
PNG
(US10011627, 3)
Show SMILES OC[C@H]1S[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1cc2CCOc2c(Cc2ccc3OCCOc3c2)c1
Show InChI InChI=1S/C23H26O7S/c24-11-18-19(25)20(26)21(27)23(31-18)15-9-13-3-4-30-22(13)14(10-15)7-12-1-2-16-17(8-12)29-6-5-28-16/h1-2,8-10,18-21,23-27H,3-7,11H2/t18-,19-,20+,21-,23+/m1/s1
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.56E+3n/an/an/an/an/an/a



YOUNGENE THERAPEUTICS CO., LTD

US Patent


Assay Description
The following method was used to determine the inhibitory activity of the compounds of the present invention on SGLT1 and SGLT2. The experimental met...


US Patent US10011627 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%