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Patent code US10017468

Compile Data Set for Download or QSAR

Found 277 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM403764
PNG
((2S,5R)-1-(3-((4-chlorobenzyl)oxy)-5-methoxybenzoy...)
Show SMILES COc1cc(OCc2ccc(Cl)cc2)cc(c1)C(=O)N1[C@@H](CC[C@@H]1c1ccccc1Cl)C(O)=O
Show InChI InChI=1S/C26H23Cl2NO5/c1-33-19-12-17(13-20(14-19)34-15-16-6-8-18(27)9-7-16)25(30)29-23(10-11-24(29)26(31)32)21-4-2-3-5-22(21)28/h2-9,12-14,23-24H,10-11,15H2,1H3,(H,31,32)/t23-,24+/m1/s1
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Ogeda SA

US Patent


Assay Description
The following assay can be used for determination of GPR43 activation. When a GPCR is in its active state, either as a result of ligand binding or co...


US Patent US10017468 (2018)


BindingDB Entry DOI: 10.7270/Q2HM5BST
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM403803
PNG
((2S,5R)-5-(2-chlorophenyl)-1-(4-isobutylbenzoyl)py...)
Show SMILES CC(C)Cc1ccc(cc1)C(=O)N1[C@@H](CC[C@@H]1c1ccccc1Cl)C=O
Show InChI InChI=1S/C22H24ClNO2/c1-15(2)13-16-7-9-17(10-8-16)22(26)24-18(14-25)11-12-21(24)19-5-3-4-6-20(19)23/h3-10,14-15,18,21H,11-13H2,1-2H3/t18-,21+/m0/s1
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Ogeda SA

US Patent


Assay Description
The following assay can be used for determination of GPR43 activation. When a GPCR is in its active state, either as a result of ligand binding or co...


US Patent US10017468 (2018)


BindingDB Entry DOI: 10.7270/Q2HM5BST
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM403806
PNG
((2S,5R)-5-(2-chlorophenyl)-1-(3-methoxy-5-(2-metho...)
Show SMILES OC(=O)[C@@H]1CC[C@@H](N1C(=O)c1ccc(cc1)-c1ccccc1)c1ccccc1
Show InChI InChI=1S/C24H21NO3/c26-23(20-13-11-18(12-14-20)17-7-3-1-4-8-17)25-21(15-16-22(25)24(27)28)19-9-5-2-6-10-19/h1-14,21-22H,15-16H2,(H,27,28)/t21-,22+/m1/s1
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Ogeda SA

US Patent


Assay Description
The following assay can be used for determination of GPR43 activation. When a GPCR is in its active state, either as a result of ligand binding or co...


US Patent US10017468 (2018)


BindingDB Entry DOI: 10.7270/Q2HM5BST
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM403811
PNG
((2S,5R)-5-(2-chlorophenyl)-1-(3-((3,5-dimethylisox...)
Show SMILES COc1cc(OCc2c(C)noc2C)cc(c1)C(=O)N1[C@@H](CC[C@@H]1c1ccccc1Cl)C(O)=O
Show InChI InChI=1S/C25H25ClN2O6/c1-14-20(15(2)34-27-14)13-33-18-11-16(10-17(12-18)32-3)24(29)28-22(8-9-23(28)25(30)31)19-6-4-5-7-21(19)26/h4-7,10-12,22-23H,8-9,13H2,1-3H3,(H,30,31)/t22-,23+/m1/s1
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Ogeda SA

US Patent


Assay Description
The following assay can be used for determination of GPR43 activation. When a GPCR is in its active state, either as a result of ligand binding or co...


US Patent US10017468 (2018)


BindingDB Entry DOI: 10.7270/Q2HM5BST
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM403816
PNG
((2S,5R)-5-(2-chlorophenyl)-1-(4-(trifluoromethoxy)...)
Show SMILES OC(=O)[C@@H]1CC[C@@H](N1C(=O)c1ccc(OC(F)(F)F)cc1)c1ccccc1Cl
Show InChI InChI=1S/C19H15ClF3NO4/c20-14-4-2-1-3-13(14)15-9-10-16(18(26)27)24(15)17(25)11-5-7-12(8-6-11)28-19(21,22)23/h1-8,15-16H,9-10H2,(H,26,27)/t15-,16+/m1/s1
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Ogeda SA

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Assay Description
The following assay can be used for determination of GPR43 activation. When a GPCR is in its active state, either as a result of ligand binding or co...


US Patent US10017468 (2018)


BindingDB Entry DOI: 10.7270/Q2HM5BST
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM403831
PNG
((2S,5R)-1-(2-([1,1'-biphenyl]-4-yl)acetyl)-5-(2-ch...)
Show SMILES OC(=O)[C@@H]1CC[C@@H](N1C(=O)Cc1ccc(cc1)-c1ccccc1)c1ccccc1Cl
Show InChI InChI=1S/C25H22ClNO3/c26-21-9-5-4-8-20(21)22-14-15-23(25(29)30)27(22)24(28)16-17-10-12-19(13-11-17)18-6-2-1-3-7-18/h1-13,22-23H,14-16H2,(H,29,30)/t22-,23+/m1/s1
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Ogeda SA

US Patent


Assay Description
The following assay can be used for determination of GPR43 activation. When a GPCR is in its active state, either as a result of ligand binding or co...


US Patent US10017468 (2018)


BindingDB Entry DOI: 10.7270/Q2HM5BST
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM403837
PNG
((2S,5R)-5-(2-chlorophenyl)-1-(4-(pyridin-2-yl)benz...)
Show SMILES OC(=O)[C@@H]1CC[C@@H](N1C(=O)c1ccc(cc1)-c1ccccn1)c1ccccc1Cl
Show InChI InChI=1S/C23H19ClN2O3/c24-18-6-2-1-5-17(18)20-12-13-21(23(28)29)26(20)22(27)16-10-8-15(9-11-16)19-7-3-4-14-25-19/h1-11,14,20-21H,12-13H2,(H,28,29)/t20-,21+/m1/s1
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Assay Description
The following assay can be used for determination of GPR43 activation. When a GPCR is in its active state, either as a result of ligand binding or co...


US Patent US10017468 (2018)


BindingDB Entry DOI: 10.7270/Q2HM5BST
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM403841
PNG
((2S,5R)-5-(2-chlorophenyl)-1-(4-((3,5-dimethylisox...)
Show SMILES Cc1noc(C)c1COc1ccc(cc1)C(=O)N1[C@@H](CC[C@@H]1c1ccccc1Cl)C(O)=O
Show InChI InChI=1S/C24H23ClN2O5/c1-14-19(15(2)32-26-14)13-31-17-9-7-16(8-10-17)23(28)27-21(11-12-22(27)24(29)30)18-5-3-4-6-20(18)25/h3-10,21-22H,11-13H2,1-2H3,(H,29,30)/t21-,22+/m1/s1
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Assay Description
The following assay can be used for determination of GPR43 activation. When a GPCR is in its active state, either as a result of ligand binding or co...


US Patent US10017468 (2018)


BindingDB Entry DOI: 10.7270/Q2HM5BST
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM403854
PNG
((2S,5R)-5-(2-chlorophenyl)-1-(4-(pyrimidin-5-yl)be...)
Show SMILES OC(=O)[C@@H]1CC[C@@H](N1C(=O)c1ccc(cc1)-c1cncnc1)c1ccccc1Cl
Show InChI InChI=1S/C22H18ClN3O3/c23-18-4-2-1-3-17(18)19-9-10-20(22(28)29)26(19)21(27)15-7-5-14(6-8-15)16-11-24-13-25-12-16/h1-8,11-13,19-20H,9-10H2,(H,28,29)/t19-,20+/m1/s1
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Ogeda SA

US Patent


Assay Description
The following assay can be used for determination of GPR43 activation. When a GPCR is in its active state, either as a result of ligand binding or co...


US Patent US10017468 (2018)


BindingDB Entry DOI: 10.7270/Q2HM5BST
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM403866
PNG
((2S,5R)-5-(2-chlorophenyl)-1-(4'-methoxy-[1,1'-bip...)
Show SMILES COc1ccc(cc1)-c1ccc(cc1)C(=O)N1[C@@H](CC[C@@H]1c1ccccc1Cl)C(O)=O
Show InChI InChI=1S/C25H22ClNO4/c1-31-19-12-10-17(11-13-19)16-6-8-18(9-7-16)24(28)27-22(14-15-23(27)25(29)30)20-4-2-3-5-21(20)26/h2-13,22-23H,14-15H2,1H3,(H,29,30)/t22-,23+/m1/s1
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Ogeda SA

US Patent


Assay Description
The following assay can be used for determination of GPR43 activation. When a GPCR is in its active state, either as a result of ligand binding or co...


US Patent US10017468 (2018)


BindingDB Entry DOI: 10.7270/Q2HM5BST
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM403867
PNG
((2S,5R)-5-(2-chlorophenyl)-1-(4-(4-methoxypyridin-...)
Show SMILES COc1ccncc1-c1ccc(cc1)C(=O)N1[C@@H](CC[C@@H]1c1ccccc1Cl)C(O)=O
Show InChI InChI=1S/C24H21ClN2O4/c1-31-22-12-13-26-14-18(22)15-6-8-16(9-7-15)23(28)27-20(10-11-21(27)24(29)30)17-4-2-3-5-19(17)25/h2-9,12-14,20-21H,10-11H2,1H3,(H,29,30)/t20-,21+/m1/s1
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Assay Description
The following assay can be used for determination of GPR43 activation. When a GPCR is in its active state, either as a result of ligand binding or co...


US Patent US10017468 (2018)


BindingDB Entry DOI: 10.7270/Q2HM5BST
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM403905
PNG
((2S,5R)-5-(2-chlorophenyl)-1-(9-methyl-9H-carbazol...)
Show SMILES Cn1c2ccccc2c2ccc(cc12)C(=O)N1[C@@H](CC[C@@H]1c1ccccc1Cl)C(O)=O
Show InChI InChI=1S/C25H21ClN2O3/c1-27-20-9-5-3-6-16(20)17-11-10-15(14-23(17)27)24(29)28-21(12-13-22(28)25(30)31)18-7-2-4-8-19(18)26/h2-11,14,21-22H,12-13H2,1H3,(H,30,31)/t21-,22+/m1/s1
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Ogeda SA

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Assay Description
The following assay can be used for determination of GPR43 activation. When a GPCR is in its active state, either as a result of ligand binding or co...


US Patent US10017468 (2018)


BindingDB Entry DOI: 10.7270/Q2HM5BST
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM403915
PNG
((2S,5R)-5-(2-chlorophenyl)-1-(4-(4-chlorophenyl)cy...)
Show SMILES OC(=O)[C@@H]1CC[C@@H](N1C(=O)C1CCC(CC1)c1ccc(Cl)cc1)c1ccccc1Cl
Show InChI InChI=1S/C24H25Cl2NO3/c25-18-11-9-16(10-12-18)15-5-7-17(8-6-15)23(28)27-21(13-14-22(27)24(29)30)19-3-1-2-4-20(19)26/h1-4,9-12,15,17,21-22H,5-8,13-14H2,(H,29,30)/t15?,17?,21-,22+/m1/s1
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Assay Description
The following assay can be used for determination of GPR43 activation. When a GPCR is in its active state, either as a result of ligand binding or co...


US Patent US10017468 (2018)


BindingDB Entry DOI: 10.7270/Q2HM5BST
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM403916
PNG
((2S,5R)-5-(2-chlorophenyl)-1-(4-phenylcyclohexanec...)
Show SMILES OC(=O)[C@@H]1CC[C@@H](N1C(=O)C1CCC(CC1)c1ccccc1)c1ccccc1Cl
Show InChI InChI=1S/C24H26ClNO3/c25-20-9-5-4-8-19(20)21-14-15-22(24(28)29)26(21)23(27)18-12-10-17(11-13-18)16-6-2-1-3-7-16/h1-9,17-18,21-22H,10-15H2,(H,28,29)/t17?,18?,21-,22+/m1/s1
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Assay Description
The following assay can be used for determination of GPR43 activation. When a GPCR is in its active state, either as a result of ligand binding or co...


US Patent US10017468 (2018)


BindingDB Entry DOI: 10.7270/Q2HM5BST
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM403936
PNG
((2S,5R)-5-(2-chlorophenyl)-1-(2',4'-dichloro-[1,1'...)
Show SMILES OC(=O)[C@@H]1CC[C@@H](N1C(=O)c1ccc(cc1)-c1ccc(Cl)cc1Cl)c1ccccc1Cl
Show InChI InChI=1S/C24H18Cl3NO3/c25-16-9-10-17(20(27)13-16)14-5-7-15(8-6-14)23(29)28-21(11-12-22(28)24(30)31)18-3-1-2-4-19(18)26/h1-10,13,21-22H,11-12H2,(H,30,31)/t21-,22+/m1/s1
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US Patent


Assay Description
The following assay can be used for determination of GPR43 activation. When a GPCR is in its active state, either as a result of ligand binding or co...


US Patent US10017468 (2018)


BindingDB Entry DOI: 10.7270/Q2HM5BST
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM403941
PNG
((2S,5R)-5-(2-chlorophenyl)-1-(2',4'-dimethoxy-[1,1...)
Show SMILES COc1ccc(c(OC)c1)-c1ccc(cc1)C(=O)N1[C@@H](CC[C@@H]1c1ccccc1Cl)C(O)=O
Show InChI InChI=1S/C26H24ClNO5/c1-32-18-11-12-19(24(15-18)33-2)16-7-9-17(10-8-16)25(29)28-22(13-14-23(28)26(30)31)20-5-3-4-6-21(20)27/h3-12,15,22-23H,13-14H2,1-2H3,(H,30,31)/t22-,23+/m1/s1
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Assay Description
The following assay can be used for determination of GPR43 activation. When a GPCR is in its active state, either as a result of ligand binding or co...


US Patent US10017468 (2018)


BindingDB Entry DOI: 10.7270/Q2HM5BST
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM403949
PNG
((2S,5R)-5-(2-chlorophenyl)-1-(4-(2-methylthiophen-...)
Show SMILES Cc1sccc1-c1ccc(cc1)C(=O)N1[C@@H](CC[C@@H]1c1ccccc1Cl)C(O)=O
Show InChI InChI=1S/C23H20ClNO3S/c1-14-17(12-13-29-14)15-6-8-16(9-7-15)22(26)25-20(10-11-21(25)23(27)28)18-4-2-3-5-19(18)24/h2-9,12-13,20-21H,10-11H2,1H3,(H,27,28)/t20-,21+/m1/s1
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Ogeda SA

US Patent


Assay Description
The following assay can be used for determination of GPR43 activation. When a GPCR is in its active state, either as a result of ligand binding or co...


US Patent US10017468 (2018)


BindingDB Entry DOI: 10.7270/Q2HM5BST
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM403968
PNG
((2S,5R)-5-(2-chlorophenyl)-1-(4-(2,6-dimethoxypyri...)
Show SMILES COc1ccc(c(OC)n1)-c1ccc(cc1)C(=O)N1[C@@H](CC[C@@H]1c1ccccc1Cl)C(O)=O
Show InChI InChI=1S/C25H23ClN2O5/c1-32-22-14-11-17(23(27-22)33-2)15-7-9-16(10-8-15)24(29)28-20(12-13-21(28)25(30)31)18-5-3-4-6-19(18)26/h3-11,14,20-21H,12-13H2,1-2H3,(H,30,31)/t20-,21+/m1/s1
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Ogeda SA

US Patent


Assay Description
The following assay can be used for determination of GPR43 activation. When a GPCR is in its active state, either as a result of ligand binding or co...


US Patent US10017468 (2018)


BindingDB Entry DOI: 10.7270/Q2HM5BST
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM403979
PNG
((2S,5R)-5-(2-chlorophenyl)-1-(4-(2-(2-methoxyethox...)
Show SMILES COCCOc1ncccc1-c1ccc(cc1)C(=O)N1[C@@H](CC[C@@H]1c1ccccc1Cl)C(O)=O
Show InChI InChI=1S/C26H25ClN2O5/c1-33-15-16-34-24-19(6-4-14-28-24)17-8-10-18(11-9-17)25(30)29-22(12-13-23(29)26(31)32)20-5-2-3-7-21(20)27/h2-11,14,22-23H,12-13,15-16H2,1H3,(H,31,32)/t22-,23+/m1/s1
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Ogeda SA

US Patent


Assay Description
The following assay can be used for determination of GPR43 activation. When a GPCR is in its active state, either as a result of ligand binding or co...


US Patent US10017468 (2018)


BindingDB Entry DOI: 10.7270/Q2HM5BST
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM403980
PNG
((2S,5R)-5-(2-chlorophenyl)-1-(4-(3-methoxypyrazin-...)
Show SMILES COc1nccnc1-c1ccc(cc1)C(=O)N1[C@@H](CC[C@@H]1c1ccccc1Cl)C(O)=O
Show InChI InChI=1S/C23H20ClN3O4/c1-31-21-20(25-12-13-26-21)14-6-8-15(9-7-14)22(28)27-18(10-11-19(27)23(29)30)16-4-2-3-5-17(16)24/h2-9,12-13,18-19H,10-11H2,1H3,(H,29,30)/t18-,19+/m1/s1
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Ogeda SA

US Patent


Assay Description
The following assay can be used for determination of GPR43 activation. When a GPCR is in its active state, either as a result of ligand binding or co...


US Patent US10017468 (2018)


BindingDB Entry DOI: 10.7270/Q2HM5BST
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM403991
PNG
((2S,5R)-1-(4-(2,6-dimethoxypyridin-3-yl)benzoyl)-5...)
Show SMILES COc1ccc(c(OC)n1)-c1ccc(cc1)C(=O)N1[C@@H](CC[C@@H]1c1ccccc1F)C(O)=O
Show InChI InChI=1S/C25H23FN2O5/c1-32-22-14-11-17(23(27-22)33-2)15-7-9-16(10-8-15)24(29)28-20(12-13-21(28)25(30)31)18-5-3-4-6-19(18)26/h3-11,14,20-21H,12-13H2,1-2H3,(H,30,31)/t20-,21+/m1/s1
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Ogeda SA

US Patent


Assay Description
The following assay can be used for determination of GPR43 activation. When a GPCR is in its active state, either as a result of ligand binding or co...


US Patent US10017468 (2018)


BindingDB Entry DOI: 10.7270/Q2HM5BST
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM404122
PNG
((2S,5R)-5-(2-chlorophenyl)-1-(2',3'-dimethoxy-[1,1...)
Show SMILES COc1cccc(-c2ccc(cc2)C(=O)N2[C@@H](CC[C@@H]2c2ccccc2Cl)C(O)=O)c1OC
Show InChI InChI=1S/C26H24ClNO5/c1-32-23-9-5-7-18(24(23)33-2)16-10-12-17(13-11-16)25(29)28-21(14-15-22(28)26(30)31)19-6-3-4-8-20(19)27/h3-13,21-22H,14-15H2,1-2H3,(H,30,31)/t21-,22+/m1/s1
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Ogeda SA

US Patent


Assay Description
The following assay can be used for determination of GPR43 activation. When a GPCR is in its active state, either as a result of ligand binding or co...


US Patent US10017468 (2018)


BindingDB Entry DOI: 10.7270/Q2HM5BST
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM404124
PNG
((2S,5R)-5-(2-chlorophenyl)-1-(3',4'-dimethoxy-[1,1...)
Show SMILES COc1ccc(cc1OC)-c1ccc(cc1)C(=O)N1[C@@H](CC[C@@H]1c1ccccc1Cl)C(O)=O
Show InChI InChI=1S/C26H24ClNO5/c1-32-23-14-11-18(15-24(23)33-2)16-7-9-17(10-8-16)25(29)28-21(12-13-22(28)26(30)31)19-5-3-4-6-20(19)27/h3-11,14-15,21-22H,12-13H2,1-2H3,(H,30,31)/t21-,22+/m1/s1
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Ogeda SA

US Patent


Assay Description
The following assay can be used for determination of GPR43 activation. When a GPCR is in its active state, either as a result of ligand binding or co...


US Patent US10017468 (2018)


BindingDB Entry DOI: 10.7270/Q2HM5BST
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM404141
PNG
((2S,5R)-5-cyclopentyl-1-(2'-methoxy-[1,1'-biphenyl...)
Show SMILES COc1ccccc1-c1ccc(cc1)C(=O)N1[C@H](CC[C@H]1C(O)=O)C1CCCC1
Show InChI InChI=1S/C24H27NO4/c1-29-22-9-5-4-8-19(22)16-10-12-18(13-11-16)23(26)25-20(17-6-2-3-7-17)14-15-21(25)24(27)28/h4-5,8-13,17,20-21H,2-3,6-7,14-15H2,1H3,(H,27,28)/t20-,21+/m1/s1
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Ogeda SA

US Patent


Assay Description
The following assay can be used for determination of GPR43 activation. When a GPCR is in its active state, either as a result of ligand binding or co...


US Patent US10017468 (2018)


BindingDB Entry DOI: 10.7270/Q2HM5BST
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM404147
PNG
((2S,5R)-1-([1,1':4',1''-terphenyl]-4-carbonyl)-5-(...)
Show SMILES OC(=O)[C@@H]1CC[C@@H](N1C(=O)c1ccc(cc1)-c1ccc(cc1)-c1ccccc1)c1ccccc1Cl
Show InChI InChI=1S/C30H24ClNO3/c31-26-9-5-4-8-25(26)27-18-19-28(30(34)35)32(27)29(33)24-16-14-23(15-17-24)22-12-10-21(11-13-22)20-6-2-1-3-7-20/h1-17,27-28H,18-19H2,(H,34,35)/t27-,28+/m1/s1
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Ogeda SA

US Patent


Assay Description
The following assay can be used for determination of GPR43 activation. When a GPCR is in its active state, either as a result of ligand binding or co...


US Patent US10017468 (2018)


BindingDB Entry DOI: 10.7270/Q2HM5BST
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM404163
PNG
((2S,5R)-5-(2-fluorophenyl)-1-(5-methoxy-6-(2-metho...)
Show SMILES COc1ccccc1-c1ncc(cc1OC)C(=O)N1[C@@H](CC[C@@H]1c1ccccc1F)C(O)=O
Show InChI InChI=1S/C25H23FN2O5/c1-32-21-10-6-4-8-17(21)23-22(33-2)13-15(14-27-23)24(29)28-19(11-12-20(28)25(30)31)16-7-3-5-9-18(16)26/h3-10,13-14,19-20H,11-12H2,1-2H3,(H,30,31)/t19-,20+/m1/s1
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Ogeda SA

US Patent


Assay Description
The following assay can be used for determination of GPR43 activation. When a GPCR is in its active state, either as a result of ligand binding or co...


US Patent US10017468 (2018)


BindingDB Entry DOI: 10.7270/Q2HM5BST
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM404181
PNG
((2S,5R)-5-(2-chlorophenyl)-1-(4-(4,6-dimethoxypyri...)
Show SMILES COc1cc(OC)c(cn1)-c1ccc(cc1)C(=O)N1[C@@H](CC[C@@H]1c1ccccc1Cl)C(O)=O
Show InChI InChI=1S/C25H23ClN2O5/c1-32-22-13-23(33-2)27-14-18(22)15-7-9-16(10-8-15)24(29)28-20(11-12-21(28)25(30)31)17-5-3-4-6-19(17)26/h3-10,13-14,20-21H,11-12H2,1-2H3,(H,30,31)/t20-,21+/m1/s1
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Ogeda SA

US Patent


Assay Description
The following assay can be used for determination of GPR43 activation. When a GPCR is in its active state, either as a result of ligand binding or co...


US Patent US10017468 (2018)


BindingDB Entry DOI: 10.7270/Q2HM5BST
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM404193
PNG
((2S,5R)-5-(2-chlorophenyl)-1-(2',3,6'-trimethoxy-[...)
Show SMILES COc1ccc(c(OC)n1)-c1ncc(cc1OC)C(=O)N1[C@@H](CC[C@@H]1c1ccccc1Cl)C(O)=O
Show InChI InChI=1S/C25H24ClN3O6/c1-33-20-12-14(13-27-22(20)16-8-11-21(34-2)28-23(16)35-3)24(30)29-18(9-10-19(29)25(31)32)15-6-4-5-7-17(15)26/h4-8,11-13,18-19H,9-10H2,1-3H3,(H,31,32)/t18-,19+/m1/s1
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Ogeda SA

US Patent


Assay Description
The following assay can be used for determination of GPR43 activation. When a GPCR is in its active state, either as a result of ligand binding or co...


US Patent US10017468 (2018)


BindingDB Entry DOI: 10.7270/Q2HM5BST
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM404202
PNG
((2S,5R)-5-(2-chlorophenyl)-1-(4-(2,6-dimethoxypyri...)
Show SMILES COc1ccc(c(OC)n1)-c1ccc(cc1F)C(=O)N1[C@@H](CC[C@@H]1c1ccccc1Cl)C(O)=O
Show InChI InChI=1S/C25H22ClFN2O5/c1-33-22-12-9-16(23(28-22)34-2)15-8-7-14(13-19(15)27)24(30)29-20(10-11-21(29)25(31)32)17-5-3-4-6-18(17)26/h3-9,12-13,20-21H,10-11H2,1-2H3,(H,31,32)/t20-,21+/m1/s1
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Ogeda SA

US Patent


Assay Description
The following assay can be used for determination of GPR43 activation. When a GPCR is in its active state, either as a result of ligand binding or co...


US Patent US10017468 (2018)


BindingDB Entry DOI: 10.7270/Q2HM5BST
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM404203
PNG
((2S,5R)-5-(2-chlorophenyl)-1-(3-fluoro-4-(6-methox...)
Show SMILES COc1ccc(cn1)-c1ccc(cc1F)C(=O)N1[C@@H](CC[C@@H]1c1ccccc1Cl)C(O)=O
Show InChI InChI=1S/C24H20ClFN2O4/c1-32-22-11-7-15(13-27-22)16-8-6-14(12-19(16)26)23(29)28-20(9-10-21(28)24(30)31)17-4-2-3-5-18(17)25/h2-8,11-13,20-21H,9-10H2,1H3,(H,30,31)/t20-,21+/m1/s1
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Ogeda SA

US Patent


Assay Description
The following assay can be used for determination of GPR43 activation. When a GPCR is in its active state, either as a result of ligand binding or co...


US Patent US10017468 (2018)


BindingDB Entry DOI: 10.7270/Q2HM5BST
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM404204
PNG
((2S,5R)-5-(2-chlorophenyl)-1-(1-(2-cyano-4-(triflu...)
Show SMILES OC(=O)[C@@H]1CC[C@@H](N1C(=O)C1CCN(CC1)c1ccc(cc1C#N)C(F)(F)F)c1ccccc1Cl
Show InChI InChI=1S/C25H23ClF3N3O3/c26-19-4-2-1-3-18(19)21-7-8-22(24(34)35)32(21)23(33)15-9-11-31(12-10-15)20-6-5-17(25(27,28)29)13-16(20)14-30/h1-6,13,15,21-22H,7-12H2,(H,34,35)/t21-,22+/m1/s1
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Ogeda SA

US Patent


Assay Description
The following assay can be used for determination of GPR43 activation. When a GPCR is in its active state, either as a result of ligand binding or co...


US Patent US10017468 (2018)


BindingDB Entry DOI: 10.7270/Q2HM5BST
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM404216
PNG
((2S,5R)-5-(2-chlorophenyl)-1-(1-(2-cyano-4-(methyl...)
Show SMILES CS(=O)(=O)Nc1ccc(N2CCC(CC2)C(=O)N2[C@@H](CC[C@@H]2c2ccccc2Cl)C(O)=O)c(c1)C#N
Show InChI InChI=1S/C25H27ClN4O5S/c1-36(34,35)28-18-6-7-21(17(14-18)15-27)29-12-10-16(11-13-29)24(31)30-22(8-9-23(30)25(32)33)19-4-2-3-5-20(19)26/h2-7,14,16,22-23,28H,8-13H2,1H3,(H,32,33)/t22-,23+/m1/s1
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Ogeda SA

US Patent


Assay Description
The following assay can be used for determination of GPR43 activation. When a GPCR is in its active state, either as a result of ligand binding or co...


US Patent US10017468 (2018)


BindingDB Entry DOI: 10.7270/Q2HM5BST
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM404217
PNG
((2S,5R)-5-(2-chlorophenyl)-1-(1-(2-cyano-4-methoxy...)
Show SMILES COc1ccc(N2CCC(CC2)C(=O)N2[C@@H](CC[C@@H]2c2ccccc2Cl)C(O)=O)c(c1)C#N
Show InChI InChI=1S/C25H26ClN3O4/c1-33-18-6-7-21(17(14-18)15-27)28-12-10-16(11-13-28)24(30)29-22(8-9-23(29)25(31)32)19-4-2-3-5-20(19)26/h2-7,14,16,22-23H,8-13H2,1H3,(H,31,32)/t22-,23+/m1/s1
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Ogeda SA

US Patent


Assay Description
The following assay can be used for determination of GPR43 activation. When a GPCR is in its active state, either as a result of ligand binding or co...


US Patent US10017468 (2018)


BindingDB Entry DOI: 10.7270/Q2HM5BST
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM404230
PNG
((2S,5R)-5-([1,1'-biphenyl]-2-yl)-1-(2'-methoxy-[1,...)
Show SMILES COc1ccccc1-c1ccc(cc1)C(=O)N1[C@@H](CC[C@@H]1c1ccccc1-c1ccccc1)C(O)=O
Show InChI InChI=1S/C31H27NO4/c1-36-29-14-8-7-12-25(29)22-15-17-23(18-16-22)30(33)32-27(19-20-28(32)31(34)35)26-13-6-5-11-24(26)21-9-3-2-4-10-21/h2-18,27-28H,19-20H2,1H3,(H,34,35)/t27-,28+/m1/s1
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Ogeda SA

US Patent


Assay Description
The following assay can be used for determination of GPR43 activation. When a GPCR is in its active state, either as a result of ligand binding or co...


US Patent US10017468 (2018)


BindingDB Entry DOI: 10.7270/Q2HM5BST
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM404238
PNG
((2S,5R)-5-(2-chlorophenyl)-1-(1-(2-methoxy-4-(trif...)
Show SMILES COc1cc(ccc1N1CCC(CC1)C(=O)N1[C@@H](CC[C@@H]1c1ccccc1Cl)C(O)=O)C(F)(F)F
Show InChI InChI=1S/C25H26ClF3N2O4/c1-35-22-14-16(25(27,28)29)6-7-20(22)30-12-10-15(11-13-30)23(32)31-19(8-9-21(31)24(33)34)17-4-2-3-5-18(17)26/h2-7,14-15,19,21H,8-13H2,1H3,(H,33,34)/t19-,21+/m1/s1
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Ogeda SA

US Patent


Assay Description
The following assay can be used for determination of GPR43 activation. When a GPCR is in its active state, either as a result of ligand binding or co...


US Patent US10017468 (2018)


BindingDB Entry DOI: 10.7270/Q2HM5BST
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM404253
PNG
((2S,5R)-5-(2,3-difluorophenyl)-1-(4-(2,4-dimethoxy...)
Show SMILES COc1ncc(c(OC)n1)-c1ccc(cc1)C(=O)N1[C@@H](CC[C@@H]1c1cccc(F)c1F)C(O)=O
Show InChI InChI=1S/C24H21F2N3O5/c1-33-21-16(12-27-24(28-21)34-2)13-6-8-14(9-7-13)22(30)29-18(10-11-19(29)23(31)32)15-4-3-5-17(25)20(15)26/h3-9,12,18-19H,10-11H2,1-2H3,(H,31,32)/t18-,19+/m1/s1
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US Patent


Assay Description
The following assay can be used for determination of GPR43 activation. When a GPCR is in its active state, either as a result of ligand binding or co...


US Patent US10017468 (2018)


BindingDB Entry DOI: 10.7270/Q2HM5BST
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM403793
PNG
((2S,5R)-5-(2-chlorophenyl)-1-(3,5-dimethoxybenzoyl...)
Show SMILES COc1cc(OC)cc(c1)C(=O)N1[C@@H](CC[C@@H]1c1ccccc1Cl)C(O)=O
Show InChI InChI=1S/C20H20ClNO5/c1-26-13-9-12(10-14(11-13)27-2)19(23)22-17(7-8-18(22)20(24)25)15-5-3-4-6-16(15)21/h3-6,9-11,17-18H,7-8H2,1-2H3,(H,24,25)/t17-,18+/m1/s1
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US Patent


Assay Description
The following assay can be used for determination of GPR43 activation. When a GPCR is in its active state, either as a result of ligand binding or co...


US Patent US10017468 (2018)


BindingDB Entry DOI: 10.7270/Q2HM5BST
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM403804
PNG
((2S,5R)-5-(2-chlorophenyl)-1-(2,2-difluorobenzo[d]...)
Show SMILES CC(C)Cc1ccc(cc1)C(=O)N1[C@@H](CC[C@@H]1c1ccccc1Cl)C(O)=O
Show InChI InChI=1S/C22H24ClNO3/c1-14(2)13-15-7-9-16(10-8-15)21(25)24-19(11-12-20(24)22(26)27)17-5-3-4-6-18(17)23/h3-10,14,19-20H,11-13H2,1-2H3,(H,26,27)/t19-,20+/m1/s1
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Ogeda SA

US Patent


Assay Description
The following assay can be used for determination of GPR43 activation. When a GPCR is in its active state, either as a result of ligand binding or co...


US Patent US10017468 (2018)


BindingDB Entry DOI: 10.7270/Q2HM5BST
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM403807
PNG
((2S,5R)-5-(2-chlorophenyl)-1-(3'-methoxy-[1,1'-bip...)
Show SMILES COc1cc(F)cc(c1)C(=O)N1[C@@H](CC[C@@H]1c1ccccc1Cl)C(O)=O
Show InChI InChI=1S/C19H17ClFNO4/c1-26-13-9-11(8-12(21)10-13)18(23)22-16(6-7-17(22)19(24)25)14-4-2-3-5-15(14)20/h2-5,8-10,16-17H,6-7H2,1H3,(H,24,25)/t16-,17+/m1/s1
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Ogeda SA

US Patent


Assay Description
The following assay can be used for determination of GPR43 activation. When a GPCR is in its active state, either as a result of ligand binding or co...


US Patent US10017468 (2018)


BindingDB Entry DOI: 10.7270/Q2HM5BST
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM403810
PNG
((2S,5R)-5-(2-chlorophenyl)-1-(4-isopropoxybenzoyl)...)
Show SMILES CC(C)Oc1ccc(cc1)C(=O)N1[C@@H](CC[C@@H]1c1ccccc1Cl)C(O)=O
Show InChI InChI=1S/C21H22ClNO4/c1-13(2)27-15-9-7-14(8-10-15)20(24)23-18(11-12-19(23)21(25)26)16-5-3-4-6-17(16)22/h3-10,13,18-19H,11-12H2,1-2H3,(H,25,26)/t18-,19+/m1/s1
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Ogeda SA

US Patent


Assay Description
The following assay can be used for determination of GPR43 activation. When a GPCR is in its active state, either as a result of ligand binding or co...


US Patent US10017468 (2018)


BindingDB Entry DOI: 10.7270/Q2HM5BST
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM403815
PNG
((2S,5R)-5-(2-chlorophenyl)-1-(2-phenylpyrimidine-5...)
Show SMILES OC(=O)[C@@H]1CC[C@@H](N1C(=O)c1cnc(nc1)-c1ccccc1)c1ccccc1Cl
Show InChI InChI=1S/C22H18ClN3O3/c23-17-9-5-4-8-16(17)18-10-11-19(22(28)29)26(18)21(27)15-12-24-20(25-13-15)14-6-2-1-3-7-14/h1-9,12-13,18-19H,10-11H2,(H,28,29)/t18-,19+/m1/s1
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Ogeda SA

US Patent


Assay Description
The following assay can be used for determination of GPR43 activation. When a GPCR is in its active state, either as a result of ligand binding or co...


US Patent US10017468 (2018)


BindingDB Entry DOI: 10.7270/Q2HM5BST
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM403820
PNG
((2S,5R)-1-([1,1'-biphenyl]-4-carbonyl)-5-(3-chloro...)
Show SMILES OC(=O)[C@@H]1CC[C@@H](N1C(=O)c1ccc(cc1)-c1ccccc1)c1ncccc1Cl
Show InChI InChI=1S/C23H19ClN2O3/c24-18-7-4-14-25-21(18)19-12-13-20(23(28)29)26(19)22(27)17-10-8-16(9-11-17)15-5-2-1-3-6-15/h1-11,14,19-20H,12-13H2,(H,28,29)/t19-,20+/m1/s1
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US Patent


Assay Description
The following assay can be used for determination of GPR43 activation. When a GPCR is in its active state, either as a result of ligand binding or co...


US Patent US10017468 (2018)


BindingDB Entry DOI: 10.7270/Q2HM5BST
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM403826
PNG
((2S,5S)-5-(2-chlorophenyl)-1-(3-methoxybenzoyl)pyr...)
Show SMILES COc1cccc(c1)C(=O)N1[C@@H](CC[C@H]1c1ccccc1Cl)C(O)=O
Show InChI InChI=1S/C19H18ClNO4/c1-25-13-6-4-5-12(11-13)18(22)21-16(9-10-17(21)19(23)24)14-7-2-3-8-15(14)20/h2-8,11,16-17H,9-10H2,1H3,(H,23,24)/t16-,17-/m0/s1
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US Patent


Assay Description
The following assay can be used for determination of GPR43 activation. When a GPCR is in its active state, either as a result of ligand binding or co...


US Patent US10017468 (2018)


BindingDB Entry DOI: 10.7270/Q2HM5BST
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM403839
PNG
((2S,5R)-5-(2-chlorophenyl)-1-(4-((4-methoxyphenoxy...)
Show SMILES COc1ccc(OCc2ccc(cc2)C(=O)N2[C@@H](CC[C@@H]2c2ccccc2Cl)C(O)=O)cc1
Show InChI InChI=1S/C26H24ClNO5/c1-32-19-10-12-20(13-11-19)33-16-17-6-8-18(9-7-17)25(29)28-23(14-15-24(28)26(30)31)21-4-2-3-5-22(21)27/h2-13,23-24H,14-16H2,1H3,(H,30,31)/t23-,24+/m1/s1
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US Patent


Assay Description
The following assay can be used for determination of GPR43 activation. When a GPCR is in its active state, either as a result of ligand binding or co...


US Patent US10017468 (2018)


BindingDB Entry DOI: 10.7270/Q2HM5BST
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM403849
PNG
((2S,5R)-5-(2-chlorophenyl)-1-(4-(5-oxo-3-phenyl-4,...)
Show SMILES OC(=O)[C@@H]1CC[C@@H](N1C(=O)c1ccc(cc1)N1N=C(CC1=O)c1ccccc1)c1ccccc1Cl
Show InChI InChI=1S/C27H22ClN3O4/c28-21-9-5-4-8-20(21)23-14-15-24(27(34)35)30(23)26(33)18-10-12-19(13-11-18)31-25(32)16-22(29-31)17-6-2-1-3-7-17/h1-13,23-24H,14-16H2,(H,34,35)/t23-,24+/m1/s1
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US Patent


Assay Description
The following assay can be used for determination of GPR43 activation. When a GPCR is in its active state, either as a result of ligand binding or co...


US Patent US10017468 (2018)


BindingDB Entry DOI: 10.7270/Q2HM5BST
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM403882
PNG
((2S,5R)-5-(2-chlorophenyl)-1-(3',5'-difluoro-[1,1'...)
Show SMILES OC(=O)[C@@H]1CC[C@@H](N1C(=O)c1ccc(cc1)-c1cc(F)cc(F)c1)c1ccccc1Cl
Show InChI InChI=1S/C24H18ClF2NO3/c25-20-4-2-1-3-19(20)21-9-10-22(24(30)31)28(21)23(29)15-7-5-14(6-8-15)16-11-17(26)13-18(27)12-16/h1-8,11-13,21-22H,9-10H2,(H,30,31)/t21-,22+/m1/s1
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Ogeda SA

US Patent


Assay Description
The following assay can be used for determination of GPR43 activation. When a GPCR is in its active state, either as a result of ligand binding or co...


US Patent US10017468 (2018)


BindingDB Entry DOI: 10.7270/Q2HM5BST
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM403904
PNG
((2S,5R)-5-(2-chlorophenyl)-1-(2'-(methylsulfonyl)-...)
Show SMILES CS(=O)(=O)c1ccccc1-c1ccc(cc1)C(=O)N1[C@@H](CC[C@@H]1c1ccccc1Cl)C(O)=O
Show InChI InChI=1S/C25H22ClNO5S/c1-33(31,32)23-9-5-3-6-18(23)16-10-12-17(13-11-16)24(28)27-21(14-15-22(27)25(29)30)19-7-2-4-8-20(19)26/h2-13,21-22H,14-15H2,1H3,(H,29,30)/t21-,22+/m1/s1
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Ogeda SA

US Patent


Assay Description
The following assay can be used for determination of GPR43 activation. When a GPCR is in its active state, either as a result of ligand binding or co...


US Patent US10017468 (2018)


BindingDB Entry DOI: 10.7270/Q2HM5BST
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM403907
PNG
((2S,5R)-1-(4-benzylbenzoyl)-5-(2-chlorophenyl)pyrr...)
Show SMILES OC(=O)[C@@H]1CC[C@@H](N1C(=O)c1ccc(Cc2ccccc2)cc1)c1ccccc1Cl
Show InChI InChI=1S/C25H22ClNO3/c26-21-9-5-4-8-20(21)22-14-15-23(25(29)30)27(22)24(28)19-12-10-18(11-13-19)16-17-6-2-1-3-7-17/h1-13,22-23H,14-16H2,(H,29,30)/t22-,23+/m1/s1
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Ogeda SA

US Patent


Assay Description
The following assay can be used for determination of GPR43 activation. When a GPCR is in its active state, either as a result of ligand binding or co...


US Patent US10017468 (2018)


BindingDB Entry DOI: 10.7270/Q2HM5BST
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM403917
PNG
(((2R,5S)-2-(2-chlorophenyl)-5-(1H-tetrazol-5-yl)py...)
Show SMILES COc1ccccc1-c1ccc(cc1)C(=O)N1[C@@H](CC[C@@H]1c1ccccc1Cl)c1nnn[nH]1
Show InChI InChI=1S/C25H22ClN5O2/c1-33-23-9-5-3-6-18(23)16-10-12-17(13-11-16)25(32)31-21(19-7-2-4-8-20(19)26)14-15-22(31)24-27-29-30-28-24/h2-13,21-22H,14-15H2,1H3,(H,27,28,29,30)/t21-,22+/m1/s1
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US Patent


Assay Description
The following assay can be used for determination of GPR43 activation. When a GPCR is in its active state, either as a result of ligand binding or co...


US Patent US10017468 (2018)


BindingDB Entry DOI: 10.7270/Q2HM5BST
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM403933
PNG
((2S,5R)-5-(2-chlorophenyl)-1-(2',6'-dimethoxy-[1,1...)
Show SMILES COc1cccc(OC)c1-c1ccc(cc1)C(=O)N1[C@@H](CC[C@@H]1c1ccccc1Cl)C(O)=O
Show InChI InChI=1S/C26H24ClNO5/c1-32-22-8-5-9-23(33-2)24(22)16-10-12-17(13-11-16)25(29)28-20(14-15-21(28)26(30)31)18-6-3-4-7-19(18)27/h3-13,20-21H,14-15H2,1-2H3,(H,30,31)/t20-,21+/m1/s1
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Assay Description
The following assay can be used for determination of GPR43 activation. When a GPCR is in its active state, either as a result of ligand binding or co...


US Patent US10017468 (2018)


BindingDB Entry DOI: 10.7270/Q2HM5BST
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%