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Patent code US10017501

Compile Data Set for Download or QSAR
Found 84 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))		BDBM404301
PNG
(US10017501, Compound 1020-289)
Show SMILES Cc1noc(C)c1-c1cc(c2nc([nH]c2c1)C1CC1)C(O)(C1CCCO1)c1ccccc1
GoogleScholar
PC cid
PC sid
UniChem
US Patent
 2n/an/an/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 2 domain(BRD4 BD2)


(Homo sapiens (Human))		BDBM404301
PNG
(US10017501, Compound 1020-289)
Show SMILES Cc1noc(C)c1-c1cc(c2nc([nH]c2c1)C1CC1)C(O)(C1CCCO1)c1ccccc1
GoogleScholar
PC cid
PC sid
UniChem
US Patent
 2n/an/an/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 2 domain(BRD4 BD2)


(Homo sapiens (Human))		BDBM249309
PNG
(US10017501, Compound 1020-114 | US9458145, 1020-11...)
Show SMILES Cc1noc(C)c1-c1cc(c2nc([nH]c2c1)C1CC1)C(O)(C1CCCO1)c1cccc(C)n1
GoogleScholar
PC cid
PC sid
UniChem
US Patent
 2.70n/an/an/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 2 domain(BRD4 BD2)


(Homo sapiens (Human))		BDBM249314
PNG
(US10017501, Compound 1020-298 | US9458145, 1020-29...)
Show SMILES Cc1noc(C)c1-c1cc(c2nc([nH]c2c1)C1CC1)C(O)(C1CCC(C)(C)O1)c1cccnn1
GoogleScholar
PC cid
PC sid
UniChem
US Patent
 3.60n/an/an/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))		BDBM249309
PNG
(US10017501, Compound 1020-114 | US9458145, 1020-11...)
Show SMILES Cc1noc(C)c1-c1cc(c2nc([nH]c2c1)C1CC1)C(O)(C1CCCO1)c1cccc(C)n1
GoogleScholar
PC cid
PC sid
UniChem
US Patent
 3.80n/an/an/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))		BDBM249305
PNG
(US10017501, Compound 1020-103 | US9458145, 1020-10...)
Show SMILES Cc1noc(C)c1-c1cc(c2nc([nH]c2c1)C1CC1)C(O)(c1nccs1)c1nccs1
Show InChI InChI=1S/C22H19N5O2S2/c1-11-17(12(2)29-27-11)14-9-15(18-16(10-14)25-19(26-18)13-3-4-13)22(28,20-23-5-7-30-20)21-24-6-8-31-21/h5-10,13,28H,3-4H2,1-2H3,(H,25,26)
GoogleScholar
PC cid
PC sid
UniChem
US Patent
 4n/an/an/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))		BDBM249312
PNG
(US10017501, Compound 1020-257 | US9458145, 1020-25...)
Show SMILES Cc1noc(C)c1-c1cc(c2nc([nH]c2c1)C1CC1)C(O)(c1ncccn1)c1ccc(F)cc1F
GoogleScholar
PC cid
PC sid
UniChem
US Patent
 4.70n/an/an/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))		BDBM249314
PNG
(US10017501, Compound 1020-298 | US9458145, 1020-29...)
Show SMILES Cc1noc(C)c1-c1cc(c2nc([nH]c2c1)C1CC1)C(O)(C1CCC(C)(C)O1)c1cccnn1
GoogleScholar
PC cid
PC sid
UniChem
US Patent
 5.40n/an/an/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 2 domain(BRD4 BD2)


(Homo sapiens (Human))		BDBM249312
PNG
(US10017501, Compound 1020-257 | US9458145, 1020-25...)
Show SMILES Cc1noc(C)c1-c1cc(c2nc([nH]c2c1)C1CC1)C(O)(c1ncccn1)c1ccc(F)cc1F
GoogleScholar
PC cid
PC sid
UniChem
US Patent
 5.60n/an/an/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))		BDBM249311
PNG
(US10017501, Compound 1020-239 | US9458145, 1020-23...)
Show SMILES Cc1noc(C)c1-c1cc(c2nc([nH]c2c1)C1CC1)C(O)(c1ccccn1)c1ncccn1
GoogleScholar
PC cid
PC sid
UniChem
US Patent
 5.90n/an/an/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 2 domain(BRD4 BD2)


(Homo sapiens (Human))		BDBM249311
PNG
(US10017501, Compound 1020-239 | US9458145, 1020-23...)
Show SMILES Cc1noc(C)c1-c1cc(c2nc([nH]c2c1)C1CC1)C(O)(c1ccccn1)c1ncccn1
GoogleScholar
PC cid
PC sid
UniChem
US Patent
 6n/an/an/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))		BDBM249306
PNG
(US10017501, Compound 1020-104 | US9458145, 1020-10...)
Show SMILES Cc1noc(C)c1-c1cc(c2nc([nH]c2c1)C1CC1)C(O)(c1ccccn1)c1ccccn1
Show InChI InChI=1S/C26H23N5O2/c1-15-23(16(2)33-31-15)18-13-19(24-20(14-18)29-25(30-24)17-9-10-17)26(32,21-7-3-5-11-27-21)22-8-4-6-12-28-22/h3-8,11-14,17,32H,9-10H2,1-2H3,(H,29,30)
GoogleScholar
PC cid
PC sid
UniChem
US Patent
 7.20n/an/an/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))		BDBM249307
PNG
(US10017501, Compound 1020-112 | US9458145, 1020-11...)
Show SMILES Cc1noc(C)c1-c1cc(c2nc([nH]c2c1)C1CC1)C(O)(c1ccccc1)c1cccnc1
GoogleScholar
PC cid
PC sid
UniChem
US Patent
 10.4n/an/an/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))		BDBM249308
PNG
(US10017501, Compound 1020-113 | US9458145, 1020-11...)
Show SMILES Cc1noc(C)c1-c1cc(c2nc([nH]c2c1)C1CC1)C(O)(c1ccccc1)c1ccccn1
GoogleScholar
PC cid
PC sid
UniChem
US Patent
 10.7n/an/an/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))		BDBM249310
PNG
(US10017501, Compound 1020-224 | US9458145, 1020-22...)
Show SMILES Cc1noc(C)c1-c1cc(c2nc([nH]c2c1F)C1CC1)C(O)(c1ccccn1)c1ccccn1
Show InChI InChI=1S/C26H22FN5O2/c1-14-21(15(2)34-32-14)17-13-18(23-24(22(17)27)31-25(30-23)16-9-10-16)26(33,19-7-3-5-11-28-19)20-8-4-6-12-29-20/h3-8,11-13,16,33H,9-10H2,1-2H3,(H,30,31)
GoogleScholar
PC cid
PC sid
UniChem
US Patent
 10.8n/an/an/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 2 domain(BRD4 BD2)


(Homo sapiens (Human))		BDBM249306
PNG
(US10017501, Compound 1020-104 | US9458145, 1020-10...)
Show SMILES Cc1noc(C)c1-c1cc(c2nc([nH]c2c1)C1CC1)C(O)(c1ccccn1)c1ccccn1
Show InChI InChI=1S/C26H23N5O2/c1-15-23(16(2)33-31-15)18-13-19(24-20(14-18)29-25(30-24)17-9-10-17)26(32,21-7-3-5-11-27-21)22-8-4-6-12-28-22/h3-8,11-14,17,32H,9-10H2,1-2H3,(H,29,30)
GoogleScholar
PC cid
PC sid
UniChem
US Patent
 11.7n/an/an/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 2 domain(BRD4 BD2)


(Homo sapiens (Human))		BDBM249305
PNG
(US10017501, Compound 1020-103 | US9458145, 1020-10...)
Show SMILES Cc1noc(C)c1-c1cc(c2nc([nH]c2c1)C1CC1)C(O)(c1nccs1)c1nccs1
Show InChI InChI=1S/C22H19N5O2S2/c1-11-17(12(2)29-27-11)14-9-15(18-16(10-14)25-19(26-18)13-3-4-13)22(28,20-23-5-7-30-20)21-24-6-8-31-21/h5-10,13,28H,3-4H2,1-2H3,(H,25,26)
GoogleScholar
PC cid
PC sid
UniChem
US Patent
 12.4n/an/an/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 2 domain(BRD4 BD2)


(Homo sapiens (Human))		BDBM249308
PNG
(US10017501, Compound 1020-113 | US9458145, 1020-11...)
Show SMILES Cc1noc(C)c1-c1cc(c2nc([nH]c2c1)C1CC1)C(O)(c1ccccc1)c1ccccn1
GoogleScholar
PC cid
PC sid
UniChem
US Patent
 12.8n/an/an/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 2 domain(BRD4 BD2)


(Homo sapiens (Human))		BDBM249307
PNG
(US10017501, Compound 1020-112 | US9458145, 1020-11...)
Show SMILES Cc1noc(C)c1-c1cc(c2nc([nH]c2c1)C1CC1)C(O)(c1ccccc1)c1cccnc1
GoogleScholar
PC cid
PC sid
UniChem
US Patent
 13.5n/an/an/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 2 domain(BRD4 BD2)


(Homo sapiens (Human))		BDBM249310
PNG
(US10017501, Compound 1020-224 | US9458145, 1020-22...)
Show SMILES Cc1noc(C)c1-c1cc(c2nc([nH]c2c1F)C1CC1)C(O)(c1ccccn1)c1ccccn1
Show InChI InChI=1S/C26H22FN5O2/c1-14-21(15(2)34-32-14)17-13-18(23-24(22(17)27)31-25(30-23)16-9-10-16)26(33,19-7-3-5-11-28-19)20-8-4-6-12-29-20/h3-8,11-13,16,33H,9-10H2,1-2H3,(H,30,31)
GoogleScholar
PC cid
PC sid
UniChem
US Patent
 20.2n/an/an/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 2 domain(BRD4 BD2)


(Homo sapiens (Human))		BDBM249283
PNG
(US10017501, Compound 1020-57 | US9458145, 1020-57)
Show SMILES Cc1noc(C)c1-c1cc(-c2c(C)ccnc2C)c2[nH]c(nc2c1)C1CC1
Show InChI InChI=1S/C22H22N4O/c1-11-7-8-23-12(2)19(11)17-9-16(20-13(3)26-27-14(20)4)10-18-21(17)25-22(24-18)15-5-6-15/h7-10,15H,5-6H2,1-4H3,(H,24,25)
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 54.4n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 2 domain(BRD4 BD2)


(Homo sapiens (Human))		BDBM249287
PNG
(US10017501, Compound 1020-77 | US9458145, 1020-77)
Show SMILES Cc1nc2cc(cc(-c3c(C)n[nH]c3C)c2[nH]1)-c1c(C)noc1C
Show InChI InChI=1S/C18H19N5O/c1-8-16(9(2)22-21-8)14-6-13(17-10(3)23-24-11(17)4)7-15-18(14)20-12(5)19-15/h6-7H,1-5H3,(H,19,20)(H,21,22)
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 64.8n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 2 domain(BRD4 BD2)


(Homo sapiens (Human))		BDBM249279
PNG
(US10017501, Compound 1020-28 | US9458145, 1020-28)
Show SMILES CC\C=C(/CC)c1cc(cc2nc([nH]c12)C1CC1)-c1c(C)noc1C
Show InChI InChI=1S/C21H25N3O/c1-5-7-14(6-2)17-10-16(19-12(3)24-25-13(19)4)11-18-20(17)23-21(22-18)15-8-9-15/h7,10-11,15H,5-6,8-9H2,1-4H3,(H,22,23)/b14-7+
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 65.5n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 2 domain(BRD4 BD2)


(Homo sapiens (Human))		BDBM249284
PNG
(US10017501, Compound 1020-72 | US9458145, 1020-72)
Show SMILES Cc1n[nH]c(C)c1-c1cc(cc2nc(C3CC3)n(C)c12)-c1c(C)noc1C
Show InChI InChI=1S/C21H23N5O/c1-10-18(11(2)24-23-10)16-8-15(19-12(3)25-27-13(19)4)9-17-20(16)26(5)21(22-17)14-6-7-14/h8-9,14H,6-7H2,1-5H3,(H,23,24)
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 69.1n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 2 domain(BRD4 BD2)


(Homo sapiens (Human))		BDBM249276
PNG
(US10017501, Compound 1020-12 | US9458145, 1020-12)
Show SMILES Cc1cnn(C)c1-c1cc(cc2nc([nH]c12)C1CC1)-c1c(C)noc1C
Show InChI InChI=1S/C20H21N5O/c1-10-9-21-25(4)19(10)15-7-14(17-11(2)24-26-12(17)3)8-16-18(15)23-20(22-16)13-5-6-13/h7-9,13H,5-6H2,1-4H3,(H,22,23)
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 69.2n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))		BDBM249279
PNG
(US10017501, Compound 1020-28 | US9458145, 1020-28)
Show SMILES CC\C=C(/CC)c1cc(cc2nc([nH]c12)C1CC1)-c1c(C)noc1C
Show InChI InChI=1S/C21H25N3O/c1-5-7-14(6-2)17-10-16(19-12(3)24-25-13(19)4)11-18-20(17)23-21(22-18)15-8-9-15/h7,10-11,15H,5-6,8-9H2,1-4H3,(H,22,23)/b14-7+
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UniChem
US Patent
n/an/a 71.8n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 2 domain(BRD4 BD2)


(Homo sapiens (Human))		BDBM249297
PNG
(US10017501, Compound 1020-102 | US9458145, 1020-10...)
Show SMILES Cc1noc(C)c1-c1cc(c2nc([nH]c2c1)C1CC1)C(O)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C28H25N3O2/c1-17-25(18(2)33-31-17)20-15-23(26-24(16-20)29-27(30-26)19-13-14-19)28(32,21-9-5-3-6-10-21)22-11-7-4-8-12-22/h3-12,15-16,19,32H,13-14H2,1-2H3,(H,29,30)
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UniChem
US Patent
n/an/a 75.7n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 2 domain(BRD4 BD2)


(Homo sapiens (Human))		BDBM249298
PNG
(US10017501, Compound 1020-120 | US9458145, 1020-12...)
Show SMILES CCC(CC)c1cc(cc2[nH]c(nc12)C1CC1)-c1c(C)noc1C
Show InChI InChI=1S/C20H25N3O/c1-5-13(6-2)16-9-15(18-11(3)23-24-12(18)4)10-17-19(16)22-20(21-17)14-7-8-14/h9-10,13-14H,5-8H2,1-4H3,(H,21,22)
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UniChem
US Patent
n/an/a 76.1n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 2 domain(BRD4 BD2)


(Homo sapiens (Human))		BDBM404272
PNG
(US10017501, Compound 1020-75)
Show SMILES Cc1n[nH]c(C)c1-c1cc(cc2[nH]c(nc12)C1CCC1)-c1c(C)noc1C
Show InChI InChI=1S/C21H23N5O/c1-10-18(11(2)25-24-10)16-8-15(19-12(3)26-27-13(19)4)9-17-20(16)23-21(22-17)14-6-5-7-14/h8-9,14H,5-7H2,1-4H3,(H,22,23)(H,24,25)
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UniChem
US Patent
n/an/a 78.2n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 2 domain(BRD4 BD2)


(Homo sapiens (Human))		BDBM249277
PNG
(US10017501, Compound 1020-18 | US9458145, 1020-18)
Show SMILES Cc1noc(C)c1-c1cc(-c2c(C)ccc3ncccc23)c2[nH]c(nc2c1)C1CC1
Show InChI InChI=1S/C25H22N4O/c1-13-6-9-20-18(5-4-10-26-20)22(13)19-11-17(23-14(2)29-30-15(23)3)12-21-24(19)28-25(27-21)16-7-8-16/h4-6,9-12,16H,7-8H2,1-3H3,(H,27,28)
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UniChem
US Patent
n/an/a 78.6n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 2 domain(BRD4 BD2)


(Homo sapiens (Human))		BDBM249299
PNG
(US10017501, Compound 1020-121 | US9458145, 1020-12...)
Show SMILES Cc1noc(C)c1-c1cc(C(O)C2CCCC2)c2nc([nH]c2c1)C1CC1
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UniChem
US Patent
n/an/a 80.8n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))		BDBM249277
PNG
(US10017501, Compound 1020-18 | US9458145, 1020-18)
Show SMILES Cc1noc(C)c1-c1cc(-c2c(C)ccc3ncccc23)c2[nH]c(nc2c1)C1CC1
Show InChI InChI=1S/C25H22N4O/c1-13-6-9-20-18(5-4-10-26-20)22(13)19-11-17(23-14(2)29-30-15(23)3)12-21-24(19)28-25(27-21)16-7-8-16/h4-6,9-12,16H,7-8H2,1-3H3,(H,27,28)
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UniChem
US Patent
n/an/a 87.1n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 2 domain(BRD4 BD2)


(Homo sapiens (Human))		BDBM249289
PNG
(US10017501, Compound 1020-79 | US9458145, 1020-79)
Show SMILES Cc1n[nH]c(C)c1-c1cc(cc2[nH]c(NCC3CC3)nc12)-c1c(C)noc1C
Show InChI InChI=1S/C21H24N6O/c1-10-18(11(2)26-25-10)16-7-15(19-12(3)27-28-13(19)4)8-17-20(16)24-21(23-17)22-9-14-5-6-14/h7-8,14H,5-6,9H2,1-4H3,(H,25,26)(H2,22,23,24)
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UniChem
US Patent
n/an/a 87.2n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))		BDBM249298
PNG
(US10017501, Compound 1020-120 | US9458145, 1020-12...)
Show SMILES CCC(CC)c1cc(cc2[nH]c(nc12)C1CC1)-c1c(C)noc1C
Show InChI InChI=1S/C20H25N3O/c1-5-13(6-2)16-9-15(18-11(3)23-24-12(18)4)10-17-19(16)22-20(21-17)14-7-8-14/h9-10,13-14H,5-8H2,1-4H3,(H,21,22)
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UniChem
US Patent
n/an/a 88.5n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 2 domain(BRD4 BD2)


(Homo sapiens (Human))		BDBM249288
PNG
(US10017501, Compound 1020-78 | US9458145, 1020-78)
Show SMILES Cc1n[nH]c(C)c1-c1cc(cc2nc([nH]c12)C1CC1(F)F)-c1c(C)noc1C
Show InChI InChI=1S/C20H17F2N5O/c1-8-16(9(2)26-25-8)13-5-12(17-10(3)27-28-11(17)4)6-15-18(13)24-19(23-15)14-7-20(14,21)22/h5-6,14H,7H2,1-4H3
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UniChem
US Patent
n/an/a 94.1n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))		BDBM249299
PNG
(US10017501, Compound 1020-121 | US9458145, 1020-12...)
Show SMILES Cc1noc(C)c1-c1cc(C(O)C2CCCC2)c2nc([nH]c2c1)C1CC1
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UniChem
US Patent
n/an/a 95.2n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 2 domain(BRD4 BD2)


(Homo sapiens (Human))		BDBM249296
PNG
(US10017501, Compound 1020-96 | US9458145, 1020-96)
Show SMILES Cc1n[nH]c(C)c1-c1cc(cc2nc(N)[nH]c12)-c1c(C)noc1C
Show InChI InChI=1S/C17H18N6O/c1-7-14(8(2)22-21-7)12-5-11(15-9(3)23-24-10(15)4)6-13-16(12)20-17(18)19-13/h5-6H,1-4H3,(H,21,22)(H3,18,19,20)
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UniChem
US Patent
n/an/a 96.9n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))		BDBM249285
PNG
(US10017501, Compound 1020-74 | US9458145, 1020-74)
Show SMILES Cc1noc(C)c1-c1cc(-c2c(C)ccc3ncccc23)c2n(C)c(nc2c1)C1CC1
Show InChI InChI=1S/C26H24N4O/c1-14-7-10-21-19(6-5-11-27-21)23(14)20-12-18(24-15(2)29-31-16(24)3)13-22-25(20)30(4)26(28-22)17-8-9-17/h5-7,10-13,17H,8-9H2,1-4H3
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UniChem
US Patent
n/an/a 97.1n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 2 domain(BRD4 BD2)


(Homo sapiens (Human))		BDBM249273
PNG
(US10017501, Compound 1020-1 | US9458145, 1020-1)
Show SMILES Cc1noc(C)c1-c1cc(c2nc(NCC3CC3)[nH]c2c1)S(=O)(=O)NC1CCCC1
Show InChI InChI=1S/C21H27N5O3S/c1-12-19(13(2)29-25-12)15-9-17-20(24-21(23-17)22-11-14-7-8-14)18(10-15)30(27,28)26-16-5-3-4-6-16/h9-10,14,16,26H,3-8,11H2,1-2H3,(H2,22,23,24)
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UniChem
US Patent
n/an/a 97.6n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))		BDBM249284
PNG
(US10017501, Compound 1020-72 | US9458145, 1020-72)
Show SMILES Cc1n[nH]c(C)c1-c1cc(cc2nc(C3CC3)n(C)c12)-c1c(C)noc1C
Show InChI InChI=1S/C21H23N5O/c1-10-18(11(2)24-23-10)16-8-15(19-12(3)25-27-13(19)4)9-17-20(16)26(5)21(22-17)14-6-7-14/h8-9,14H,6-7H2,1-5H3,(H,23,24)
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UniChem
US Patent
n/an/a 101n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))		BDBM249297
PNG
(US10017501, Compound 1020-102 | US9458145, 1020-10...)
Show SMILES Cc1noc(C)c1-c1cc(c2nc([nH]c2c1)C1CC1)C(O)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C28H25N3O2/c1-17-25(18(2)33-31-17)20-15-23(26-24(16-20)29-27(30-26)19-13-14-19)28(32,21-9-5-3-6-10-21)22-11-7-4-8-12-22/h3-12,15-16,19,32H,13-14H2,1-2H3,(H,29,30)
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UniChem
US Patent
n/an/a 101n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 2 domain(BRD4 BD2)


(Homo sapiens (Human))		BDBM249295
PNG
(US10017501, Compound 1020-92 | US9458145, 1020-92)
Show SMILES Cc1noc(C)c1-c1cc(-c2c(C)ccc3ncccc23)c2nc([nH]c2c1)C(F)(F)F
Show InChI InChI=1S/C23H17F3N4O/c1-11-6-7-17-15(5-4-8-27-17)19(11)16-9-14(20-12(2)30-31-13(20)3)10-18-21(16)29-22(28-18)23(24,25)26/h4-10H,1-3H3,(H,28,29)
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US Patent
n/an/a 102n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))		BDBM249292
PNG
(US10017501, Compound 1020-88 | US9458145, 1020-88)
Show SMILES Cc1noc(C)c1-c1cc(-c2c(C)ccc3ncccc23)c2nc([nH]c2c1)-c1cnn(C)c1
Show InChI InChI=1S/C26H22N6O/c1-14-7-8-21-19(6-5-9-27-21)23(14)20-10-17(24-15(2)31-33-16(24)3)11-22-25(20)30-26(29-22)18-12-28-32(4)13-18/h5-13H,1-4H3,(H,29,30)
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UniChem
US Patent
n/an/a 104n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))		BDBM249283
PNG
(US10017501, Compound 1020-57 | US9458145, 1020-57)
Show SMILES Cc1noc(C)c1-c1cc(-c2c(C)ccnc2C)c2[nH]c(nc2c1)C1CC1
Show InChI InChI=1S/C22H22N4O/c1-11-7-8-23-12(2)19(11)17-9-16(20-13(3)26-27-14(20)4)10-18-21(17)25-22(24-18)15-5-6-15/h7-10,15H,5-6H2,1-4H3,(H,24,25)
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UniChem
US Patent
n/an/a 109n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))		BDBM249294
PNG
(US10017501, Compound 1020-90 | US9458145, 1020-90)
Show SMILES COc1nc2c(cc(cc2[nH]1)-c1c(C)noc1C)-c1c(C)ccc2ncccc12
Show InChI InChI=1S/C23H20N4O2/c1-12-7-8-18-16(6-5-9-24-18)20(12)17-10-15(21-13(2)27-29-14(21)3)11-19-22(17)26-23(25-19)28-4/h5-11H,1-4H3,(H,25,26)
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US Patent
n/an/a 110n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 2 domain(BRD4 BD2)


(Homo sapiens (Human))		BDBM249281
PNG
(US10017501, Compound 1020-44 | US9458145, 1020-44)
Show SMILES CC(c1ccc(F)cc1)c1cc(cc2nc([nH]c12)C1CC1)-c1c(C)noc1C
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UniChem
US Patent
n/an/a 111n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 2 domain(BRD4 BD2)


(Homo sapiens (Human))		BDBM249303
PNG
(US10017501, Compound 1020-141 | US9458145, 1020-14...)
Show SMILES Cc1noc(C)c1-c1cc(c2nc(Cc3ccccc3)[nH]c2c1)S(=O)(=O)NC1CCCC1
Show InChI InChI=1S/C24H26N4O3S/c1-15-23(16(2)31-27-15)18-13-20-24(26-22(25-20)12-17-8-4-3-5-9-17)21(14-18)32(29,30)28-19-10-6-7-11-19/h3-5,8-9,13-14,19,28H,6-7,10-12H2,1-2H3,(H,25,26)
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UniChem
US Patent
n/an/a 111n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 2 domain(BRD4 BD2)


(Homo sapiens (Human))		BDBM249285
PNG
(US10017501, Compound 1020-74 | US9458145, 1020-74)
Show SMILES Cc1noc(C)c1-c1cc(-c2c(C)ccc3ncccc23)c2n(C)c(nc2c1)C1CC1
Show InChI InChI=1S/C26H24N4O/c1-14-7-10-21-19(6-5-11-27-21)23(14)20-12-18(24-15(2)29-31-16(24)3)13-22-25(20)30(4)26(28-22)17-8-9-17/h5-7,10-13,17H,8-9H2,1-4H3
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US Patent
n/an/a 112n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 2 domain(BRD4 BD2)


(Homo sapiens (Human))		BDBM249290
PNG
(US10017501, Compound 1020-81 | US9458145, 1020-81)
Show SMILES Cc1n[nH]c(C)c1-c1cc(cc2[nH]c(NC3CC3)nc12)-c1c(C)noc1C
Show InChI InChI=1S/C20H22N6O/c1-9-17(10(2)25-24-9)15-7-13(18-11(3)26-27-12(18)4)8-16-19(15)23-20(22-16)21-14-5-6-14/h7-8,14H,5-6H2,1-4H3,(H,24,25)(H2,21,22,23)
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US Patent
n/an/a 119n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))		BDBM404272
PNG
(US10017501, Compound 1020-75)
Show SMILES Cc1n[nH]c(C)c1-c1cc(cc2[nH]c(nc12)C1CCC1)-c1c(C)noc1C
Show InChI InChI=1S/C21H23N5O/c1-10-18(11(2)25-24-10)16-8-15(19-12(3)26-27-13(19)4)9-17-20(16)23-21(22-17)14-6-5-7-14/h8-9,14H,5-7H2,1-4H3,(H,22,23)(H,24,25)
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US Patent
n/an/a 121n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 2 domain(BRD4 BD2)


(Homo sapiens (Human))		BDBM249294
PNG
(US10017501, Compound 1020-90 | US9458145, 1020-90)
Show SMILES COc1nc2c(cc(cc2[nH]1)-c1c(C)noc1C)-c1c(C)ccc2ncccc12
Show InChI InChI=1S/C23H20N4O2/c1-12-7-8-18-16(6-5-9-24-18)20(12)17-10-15(21-13(2)27-29-14(21)3)11-19-22(17)26-23(25-19)28-4/h5-11H,1-4H3,(H,25,26)
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US Patent
n/an/a 121n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 2 domain(BRD4 BD2)


(Homo sapiens (Human))		BDBM249292
PNG
(US10017501, Compound 1020-88 | US9458145, 1020-88)
Show SMILES Cc1noc(C)c1-c1cc(-c2c(C)ccc3ncccc23)c2nc([nH]c2c1)-c1cnn(C)c1
Show InChI InChI=1S/C26H22N6O/c1-14-7-8-21-19(6-5-9-27-21)23(14)20-10-17(24-15(2)31-33-16(24)3)11-22-25(20)30-26(29-22)18-12-28-32(4)13-18/h5-13H,1-4H3,(H,29,30)
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US Patent
n/an/a 131n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))		BDBM249295
PNG
(US10017501, Compound 1020-92 | US9458145, 1020-92)
Show SMILES Cc1noc(C)c1-c1cc(-c2c(C)ccc3ncccc23)c2nc([nH]c2c1)C(F)(F)F
Show InChI InChI=1S/C23H17F3N4O/c1-11-6-7-17-15(5-4-8-27-17)19(11)16-9-14(20-12(2)30-31-13(20)3)10-18-21(16)29-22(28-18)23(24,25)26/h4-10H,1-3H3,(H,28,29)
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US Patent
n/an/a 133n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))		BDBM249278
PNG
(US10017501, Compound 1020-19 | US9458145, 1020-19)
Show SMILES Cc1noc(C)c1-c1cc(-c2cccnc2-c2ccccc2)c2nc([nH]c2c1)C1CC1
Show InChI InChI=1S/C26H22N4O/c1-15-23(16(2)31-30-15)19-13-21(25-22(14-19)28-26(29-25)18-10-11-18)20-9-6-12-27-24(20)17-7-4-3-5-8-17/h3-9,12-14,18H,10-11H2,1-2H3,(H,28,29)
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US Patent
n/an/a 134n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))		BDBM249276
PNG
(US10017501, Compound 1020-12 | US9458145, 1020-12)
Show SMILES Cc1cnn(C)c1-c1cc(cc2nc([nH]c12)C1CC1)-c1c(C)noc1C
Show InChI InChI=1S/C20H21N5O/c1-10-9-21-25(4)19(10)15-7-14(17-11(2)24-26-12(17)3)8-16-18(15)23-20(22-16)13-5-6-13/h7-9,13H,5-6H2,1-4H3,(H,22,23)
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US Patent
n/an/a 138n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))		BDBM249281
PNG
(US10017501, Compound 1020-44 | US9458145, 1020-44)
Show SMILES CC(c1ccc(F)cc1)c1cc(cc2nc([nH]c12)C1CC1)-c1c(C)noc1C
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US Patent
n/an/a 139n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 2 domain(BRD4 BD2)


(Homo sapiens (Human))		BDBM249293
PNG
(US10017501, Compound 1020-89 | US9458145, 1020-89)
Show SMILES Cc1noc(C)c1-c1cc(-c2c(C)ccc3ncccc23)c2nc([nH]c2c1)C(O)CCO
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US Patent
n/an/a 151n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))		BDBM249288
PNG
(US10017501, Compound 1020-78 | US9458145, 1020-78)
Show SMILES Cc1n[nH]c(C)c1-c1cc(cc2nc([nH]c12)C1CC1(F)F)-c1c(C)noc1C
Show InChI InChI=1S/C20H17F2N5O/c1-8-16(9(2)26-25-8)13-5-12(17-10(3)27-28-11(17)4)6-15-18(13)24-19(23-15)14-7-20(14,21)22/h5-6,14H,7H2,1-4H3
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n/an/a 160n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))		BDBM249289
PNG
(US10017501, Compound 1020-79 | US9458145, 1020-79)
Show SMILES Cc1n[nH]c(C)c1-c1cc(cc2[nH]c(NCC3CC3)nc12)-c1c(C)noc1C
Show InChI InChI=1S/C21H24N6O/c1-10-18(11(2)26-25-10)16-7-15(19-12(3)27-28-13(19)4)8-17-20(16)24-21(23-17)22-9-14-5-6-14/h7-8,14H,5-6,9H2,1-4H3,(H,25,26)(H2,22,23,24)
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US Patent
n/an/a 161n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))		BDBM249290
PNG
(US10017501, Compound 1020-81 | US9458145, 1020-81)
Show SMILES Cc1n[nH]c(C)c1-c1cc(cc2[nH]c(NC3CC3)nc12)-c1c(C)noc1C
Show InChI InChI=1S/C20H22N6O/c1-9-17(10(2)25-24-9)15-7-13(18-11(3)26-27-12(18)4)8-16-19(15)23-20(22-16)21-14-5-6-14/h7-8,14H,5-6H2,1-4H3,(H,24,25)(H2,21,22,23)
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US Patent
n/an/a 169n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 2 domain(BRD4 BD2)


(Homo sapiens (Human))		BDBM249278
PNG
(US10017501, Compound 1020-19 | US9458145, 1020-19)
Show SMILES Cc1noc(C)c1-c1cc(-c2cccnc2-c2ccccc2)c2nc([nH]c2c1)C1CC1
Show InChI InChI=1S/C26H22N4O/c1-15-23(16(2)31-30-15)19-13-21(25-22(14-19)28-26(29-25)18-10-11-18)20-9-6-12-27-24(20)17-7-4-3-5-8-17/h3-9,12-14,18H,10-11H2,1-2H3,(H,28,29)
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n/an/a 172n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 2 domain(BRD4 BD2)


(Homo sapiens (Human))		BDBM249304
PNG
(US10017501, Compound 1020-148 | US9458145, 1020-14...)
Show SMILES Cc1noc(C)c1-c1cc(c2nc(NCC(F)(F)F)[nH]c2c1)S(=O)(=O)NC1CCCC1
Show InChI InChI=1S/C19H22F3N5O3S/c1-10-16(11(2)30-26-10)12-7-14-17(25-18(24-14)23-9-19(20,21)22)15(8-12)31(28,29)27-13-5-3-4-6-13/h7-8,13,27H,3-6,9H2,1-2H3,(H2,23,24,25)
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US Patent
n/an/a 180n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))		BDBM249304
PNG
(US10017501, Compound 1020-148 | US9458145, 1020-14...)
Show SMILES Cc1noc(C)c1-c1cc(c2nc(NCC(F)(F)F)[nH]c2c1)S(=O)(=O)NC1CCCC1
Show InChI InChI=1S/C19H22F3N5O3S/c1-10-16(11(2)30-26-10)12-7-14-17(25-18(24-14)23-9-19(20,21)22)15(8-12)31(28,29)27-13-5-3-4-6-13/h7-8,13,27H,3-6,9H2,1-2H3,(H2,23,24,25)
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US Patent
n/an/a 186n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))		BDBM249302
PNG
(US10017501, Compound 1020-137 | US9458145, 1020-13...)
Show SMILES CCC1CCC(=O)N1c1cc(cc2[nH]c(nc12)C1CC1)-c1c(C)noc1C
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UniChem
US Patent
n/an/a 187n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))		BDBM249273
PNG
(US10017501, Compound 1020-1 | US9458145, 1020-1)
Show SMILES Cc1noc(C)c1-c1cc(c2nc(NCC3CC3)[nH]c2c1)S(=O)(=O)NC1CCCC1
Show InChI InChI=1S/C21H27N5O3S/c1-12-19(13(2)29-25-12)15-9-17-20(24-21(23-17)22-11-14-7-8-14)18(10-15)30(27,28)26-16-5-3-4-6-16/h9-10,14,16,26H,3-8,11H2,1-2H3,(H2,22,23,24)
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US Patent
n/an/a 201n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 2 domain(BRD4 BD2)


(Homo sapiens (Human))		BDBM249274
PNG
(US10017501, Compound 1020-4 | US9458145, 1020-4)
Show SMILES CSc1nc2c(cc(cc2[nH]1)-c1c(C)noc1C)S(=O)(=O)NC1CCCC1
Show InChI InChI=1S/C18H22N4O3S2/c1-10-16(11(2)25-21-10)12-8-14-17(20-18(19-14)26-3)15(9-12)27(23,24)22-13-6-4-5-7-13/h8-9,13,22H,4-7H2,1-3H3,(H,19,20)
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US Patent
n/an/a 230n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 2 domain(BRD4 BD2)


(Homo sapiens (Human))		BDBM249291
PNG
(US10017501, Compound 1020-84 | US9458145, 1020-84)
Show SMILES Cc1noc(C)c1-c1cc(-c2c(C)ccnc2C)c2nc[nH]c2c1
Show InChI InChI=1S/C19H18N4O/c1-10-5-6-20-11(2)17(10)15-7-14(8-16-19(15)22-9-21-16)18-12(3)23-24-13(18)4/h5-9H,1-4H3,(H,21,22)
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US Patent
n/an/a 234n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))		BDBM249287
PNG
(US10017501, Compound 1020-77 | US9458145, 1020-77)
Show SMILES Cc1nc2cc(cc(-c3c(C)n[nH]c3C)c2[nH]1)-c1c(C)noc1C
Show InChI InChI=1S/C18H19N5O/c1-8-16(9(2)22-21-8)14-6-13(17-10(3)23-24-11(17)4)7-15-18(14)20-12(5)19-15/h6-7H,1-5H3,(H,19,20)(H,21,22)
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US Patent
n/an/a 244n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))		BDBM249296
PNG
(US10017501, Compound 1020-96 | US9458145, 1020-96)
Show SMILES Cc1n[nH]c(C)c1-c1cc(cc2nc(N)[nH]c12)-c1c(C)noc1C
Show InChI InChI=1S/C17H18N6O/c1-7-14(8(2)22-21-7)12-5-11(15-9(3)23-24-10(15)4)6-13-16(12)20-17(18)19-13/h5-6H,1-4H3,(H,21,22)(H3,18,19,20)
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n/an/a 276n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))		BDBM249282
PNG
(US10017501, Compound 1020-50 | US9458145, 1020-50)
Show SMILES Cc1noc(C)c1-c1cc(NC2CCCC2)c2nc([nH]c2c1)C1CC1
Show InChI InChI=1S/C20H24N4O/c1-11-18(12(2)25-24-11)14-9-16(21-15-5-3-4-6-15)19-17(10-14)22-20(23-19)13-7-8-13/h9-10,13,15,21H,3-8H2,1-2H3,(H,22,23)
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US Patent
n/an/a 299n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 2 domain(BRD4 BD2)


(Homo sapiens (Human))		BDBM249282
PNG
(US10017501, Compound 1020-50 | US9458145, 1020-50)
Show SMILES Cc1noc(C)c1-c1cc(NC2CCCC2)c2nc([nH]c2c1)C1CC1
Show InChI InChI=1S/C20H24N4O/c1-11-18(12(2)25-24-11)14-9-16(21-15-5-3-4-6-15)19-17(10-14)22-20(23-19)13-7-8-13/h9-10,13,15,21H,3-8H2,1-2H3,(H,22,23)
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UniChem
US Patent
n/an/a 318n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))		BDBM249274
PNG
(US10017501, Compound 1020-4 | US9458145, 1020-4)
Show SMILES CSc1nc2c(cc(cc2[nH]1)-c1c(C)noc1C)S(=O)(=O)NC1CCCC1
Show InChI InChI=1S/C18H22N4O3S2/c1-10-16(11(2)25-21-10)12-8-14-17(20-18(19-14)26-3)15(9-12)27(23,24)22-13-6-4-5-7-13/h8-9,13,22H,4-7H2,1-3H3,(H,19,20)
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UniChem
US Patent
n/an/a 337n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 2 domain(BRD4 BD2)


(Homo sapiens (Human))		BDBM249275
PNG
(US10017501, Compound 1020-5 | US9458145, 1020-5)
Show SMILES Cc1noc(C)c1-c1cc(c2nc([nH]c2c1)S(C)=O)S(=O)(=O)NC1CCCC1
GoogleScholar
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PC sid
UniChem
US Patent
n/an/a 357n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))		BDBM249293
PNG
(US10017501, Compound 1020-89 | US9458145, 1020-89)
Show SMILES Cc1noc(C)c1-c1cc(-c2c(C)ccc3ncccc23)c2nc([nH]c2c1)C(O)CCO
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PC sid
UniChem
US Patent
n/an/a 379n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 2 domain(BRD4 BD2)


(Homo sapiens (Human))		BDBM249302
PNG
(US10017501, Compound 1020-137 | US9458145, 1020-13...)
Show SMILES CCC1CCC(=O)N1c1cc(cc2[nH]c(nc12)C1CC1)-c1c(C)noc1C
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UniChem
US Patent
n/an/a 399n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))		BDBM249291
PNG
(US10017501, Compound 1020-84 | US9458145, 1020-84)
Show SMILES Cc1noc(C)c1-c1cc(-c2c(C)ccnc2C)c2nc[nH]c2c1
Show InChI InChI=1S/C19H18N4O/c1-10-5-6-20-11(2)17(10)15-7-14(8-16-19(15)22-9-21-16)18-12(3)23-24-13(18)4/h5-9H,1-4H3,(H,21,22)
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PC sid
UniChem
US Patent
n/an/a 481n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))		BDBM249300
PNG
(US10017501, Compound 1020-132 | US9458145, 1020-13...)
Show SMILES CCC(O)(CC)c1cc(cc2n(C)c(nc12)C1CC1)-c1c(C)noc1C
Show InChI InChI=1S/C21H27N3O2/c1-6-21(25,7-2)16-10-15(18-12(3)23-26-13(18)4)11-17-19(16)22-20(24(17)5)14-8-9-14/h10-11,14,25H,6-9H2,1-5H3
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UniChem
US Patent
n/an/a 610n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))		BDBM249275
PNG
(US10017501, Compound 1020-5 | US9458145, 1020-5)
Show SMILES Cc1noc(C)c1-c1cc(c2nc([nH]c2c1)S(C)=O)S(=O)(=O)NC1CCCC1
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UniChem
US Patent
n/an/a 616n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))		BDBM249303
PNG
(US10017501, Compound 1020-141 | US9458145, 1020-14...)
Show SMILES Cc1noc(C)c1-c1cc(c2nc(Cc3ccccc3)[nH]c2c1)S(=O)(=O)NC1CCCC1
Show InChI InChI=1S/C24H26N4O3S/c1-15-23(16(2)31-27-15)18-13-20-24(26-22(25-20)12-17-8-4-3-5-9-17)21(14-18)32(29,30)28-19-10-6-7-11-19/h3-5,8-9,13-14,19,28H,6-7,10-12H2,1-2H3,(H,25,26)
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UniChem
US Patent
n/an/a 704n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 2 domain(BRD4 BD2)


(Homo sapiens (Human))		BDBM249301
PNG
(US10017501, Compound 1020-136 | US9458145, 1020-13...)
Show SMILES CC1CCC(=O)N1c1cc(cc2[nH]c(nc12)C1CC1)-c1c(C)noc1C
GoogleScholar
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UniChem
US Patent
n/an/a 727n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))		BDBM249301
PNG
(US10017501, Compound 1020-136 | US9458145, 1020-13...)
Show SMILES CC1CCC(=O)N1c1cc(cc2[nH]c(nc12)C1CC1)-c1c(C)noc1C
GoogleScholar
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UniChem
US Patent
n/an/a 823n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 2 domain(BRD4 BD2)


(Homo sapiens (Human))		BDBM249300
PNG
(US10017501, Compound 1020-132 | US9458145, 1020-13...)
Show SMILES CCC(O)(CC)c1cc(cc2n(C)c(nc12)C1CC1)-c1c(C)noc1C
Show InChI InChI=1S/C21H27N3O2/c1-6-21(25,7-2)16-10-15(18-12(3)23-26-13(18)4)11-17-19(16)22-20(24(17)5)14-8-9-14/h10-11,14,25H,6-9H2,1-5H3
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UniChem
US Patent
n/an/a 883n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))		BDBM249280
PNG
(US10017501, Compound 1020-37 | US9458145, 1020-37)
Show SMILES Cc1noc(C)c1-c1cc(\C=C\c2ccccc2)c2[nH]c(nc2c1)C1CC1
Show InChI InChI=1S/C23H21N3O/c1-14-21(15(2)27-26-14)19-12-18(9-8-16-6-4-3-5-7-16)22-20(13-19)24-23(25-22)17-10-11-17/h3-9,12-13,17H,10-11H2,1-2H3,(H,24,25)/b9-8+
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UniChem
US Patent
n/an/a 2.09E+3n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 2 domain(BRD4 BD2)


(Homo sapiens (Human))		BDBM249280
PNG
(US10017501, Compound 1020-37 | US9458145, 1020-37)
Show SMILES Cc1noc(C)c1-c1cc(\C=C\c2ccccc2)c2[nH]c(nc2c1)C1CC1
Show InChI InChI=1S/C23H21N3O/c1-14-21(15(2)27-26-14)19-12-18(9-8-16-6-4-3-5-7-16)22-20(13-19)24-23(25-22)17-10-11-17/h3-9,12-13,17H,10-11H2,1-2H3,(H,24,25)/b9-8+
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UniChem
US Patent
n/an/a 2.51E+3n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...

US Patent US10017501 (2018)


BindingDB Entry DOI: 10.7270/Q2CV4M3Z
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%