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Patent code US10022461

Compile Data Set for Download or QSAR
Found 105 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281656
PNG
(US10022461, Compound 126)
Show SMILES Nc1cc2cc(ncc2cc1I)-n1ccc2ccncc12
Show InChI InChI=1S/C16H11IN4/c17-13-5-12-8-20-16(7-11(12)6-14(13)18)21-4-2-10-1-3-19-9-15(10)21/h1-9H,18H2
PDB

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0.180n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281558
PNG
(US10022461, Compound 9)
Show SMILES Fc1ccc2cnc(cc2c1)-n1ccc2ccncc12
Show InChI InChI=1S/C16H10FN3/c17-14-2-1-12-9-19-16(8-13(12)7-14)20-6-4-11-3-5-18-10-15(11)20/h1-10H
PDB

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UniProtKB/SwissProt

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0.220n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281645
PNG
(US10022461, Compound 115)
Show SMILES Nc1cc(F)cc2cnc(cc12)-n1ccc2ccncc12
Show InChI InChI=1S/C16H11FN4/c17-12-5-11-8-20-16(7-13(11)14(18)6-12)21-4-2-10-1-3-19-9-15(10)21/h1-9H,18H2
PDB

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UniProtKB/SwissProt

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0.224n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281560
PNG
(US10022461, Compound 12)
Show SMILES Nc1ccc2cc(ncc2c1)-n1ccc2ccncc12
Show InChI InChI=1S/C16H12N4/c17-14-2-1-12-8-16(19-9-13(12)7-14)20-6-4-11-3-5-18-10-15(11)20/h1-10H,17H2
PDB

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0.290n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281561
PNG
(US10022461, Compound 13)
Show SMILES COc1ccc2cc(ncc2c1)-n1ccc2ccncc12
Show InChI InChI=1S/C17H13N3O/c1-21-15-3-2-13-9-17(19-10-14(13)8-15)20-7-5-12-4-6-18-11-16(12)20/h2-11H,1H3
PDB

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0.290n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281633
PNG
(US10022461, Compound 103)
Show SMILES COc1cccc2cc(ncc12)-n1ccc2ccncc12
Show InChI InChI=1S/C17H13N3O/c1-21-16-4-2-3-13-9-17(19-10-14(13)16)20-8-6-12-5-7-18-11-15(12)20/h2-11H,1H3
PDB

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0.320n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281609
PNG
(US10022461, Compound 59)
Show SMILES Nc1cccc2cc(ncc12)-n1ccc2ccncc12
Show InChI InChI=1S/C16H12N4/c17-14-3-1-2-12-8-16(19-9-13(12)14)20-7-5-11-4-6-18-10-15(11)20/h1-10H,17H2
PDB

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0.330n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281563
PNG
(US10022461, Compound 14-1)
Show SMILES CNc1ccc2cnc(cc2c1)-n1ccc2ccncc12
Show InChI InChI=1S/C17H14N4/c1-18-15-3-2-13-10-20-17(9-14(13)8-15)21-7-5-12-4-6-19-11-16(12)21/h2-11,18H,1H3
PDB

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0.330n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281635
PNG
(US10022461, Compound 105)
Show SMILES Nc1cc2cnc(cc2cc1F)-n1ccc2ccncc12
Show InChI InChI=1S/C16H11FN4/c17-13-5-11-7-16(20-8-12(11)6-14(13)18)21-4-2-10-1-3-19-9-15(10)21/h1-9H,18H2
PDB

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0.383n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281559
PNG
(US10022461, Compound 11-5)
Show SMILES Nc1cccc2cnc(cc12)-n1ccc2ccncc12
Show InChI InChI=1S/C16H12N4/c17-14-3-1-2-12-9-19-16(8-13(12)14)20-7-5-11-4-6-18-10-15(11)20/h1-10H,17H2
PDB

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0.400n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281565
PNG
(US10022461, Compound 16)
Show SMILES FCCOc1ccc2cc(ncc2c1)-n1ccc2ccncc12
Show InChI InChI=1S/C18H14FN3O/c19-5-8-23-16-2-1-14-10-18(21-11-15(14)9-16)22-7-4-13-3-6-20-12-17(13)22/h1-4,6-7,9-12H,5,8H2
PDB

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0.410n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281639
PNG
(US10022461, Compound 109)
Show SMILES Nc1cc2cc(ncc2cc1F)-n1ccc2ccncc12
Show InChI InChI=1S/C16H11FN4/c17-13-5-12-8-20-16(7-11(12)6-14(13)18)21-4-2-10-1-3-19-9-15(10)21/h1-9H,18H2
PDB

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0.423n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281567
PNG
(US10022461, Compound 18)
Show SMILES Nc1c(F)ccc2cnc(cc12)-n1ccc2ccncc12
Show InChI InChI=1S/C16H11FN4/c17-13-2-1-11-8-20-15(7-12(11)16(13)18)21-6-4-10-3-5-19-9-14(10)21/h1-9H,18H2
PDB

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0.430n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281566
PNG
(US10022461, Compound 17)
Show SMILES FCOc1ccc2cc(ncc2c1)-n1ccc2ccncc12
Show InChI InChI=1S/C17H12FN3O/c18-11-22-15-2-1-13-8-17(20-9-14(13)7-15)21-6-4-12-3-5-19-10-16(12)21/h1-10H,11H2
PDB

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0.430n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281649
PNG
(US10022461, Compound 119)
Show SMILES Nc1c(I)ccc2cnc(cc12)-n1ccc2ccncc12
Show InChI InChI=1S/C16H11IN4/c17-13-2-1-11-8-20-15(7-12(11)16(13)18)21-6-4-10-3-5-19-9-14(10)21/h1-9H,18H2
PDB

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0.438n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281623
PNG
(US10022461, Compound 75)
Show SMILES Oc1ccc2cnc(cc2c1)-n1ccc2ccncc12
Show InChI InChI=1S/C16H11N3O/c20-14-2-1-12-9-18-16(8-13(12)7-14)19-6-4-11-3-5-17-10-15(11)19/h1-10,20H
PDB

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0.480n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281557
PNG
(US10022461, Compound 8)
Show SMILES c1cc2cc(ncc2[nH]1)-n1ccc2ccncc12
PDB

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0.480n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281644
PNG
(US10022461, Compound 114)
Show SMILES Nc1cc(F)c2cc(ncc2c1)-n1ccc2ccncc12
Show InChI InChI=1S/C16H11FN4/c17-14-6-12(18)5-11-8-20-16(7-13(11)14)21-4-2-10-1-3-19-9-15(10)21/h1-9H,18H2
PDB

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0.494n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281651
PNG
(US10022461, Compound 121)
Show SMILES Nc1c(I)ccc2cc(ncc12)-n1ccc2ccncc12
Show InChI InChI=1S/C16H11IN4/c17-13-2-1-11-7-15(20-8-12(11)16(13)18)21-6-4-10-3-5-19-9-14(10)21/h1-9H,18H2
PDB

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0.512n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281564
PNG
(US10022461, Compound 15)
Show SMILES Oc1ccc2cc(ncc2c1)-n1ccc2ccncc12
Show InChI InChI=1S/C16H11N3O/c20-14-2-1-12-8-16(18-9-13(12)7-14)19-6-4-11-3-5-17-10-15(11)19/h1-10,20H
PDB

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0.530n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281626
PNG
(US10022461, Compound 93)
Show SMILES CNc1cc(ccn1)-c1ccc(nc1)-n1ccc2ccncc12
Show InChI InChI=1S/C18H15N5/c1-19-17-10-14(5-8-21-17)15-2-3-18(22-11-15)23-9-6-13-4-7-20-12-16(13)23/h2-12H,1H3,(H,19,21)
PDB

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0.530n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281555
PNG
(US10022461, Compound 6)
Show SMILES c1cc2ccncc2n1-c1cc2ccccc2cn1
Show InChI InChI=1S/C16H11N3/c1-2-4-14-10-18-16(9-13(14)3-1)19-8-6-12-5-7-17-11-15(12)19/h1-11H
PDB

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0.540n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281630
PNG
(US10022461, Compound 99)
Show SMILES Nc1cc(ccn1)-c1ccc(nc1)-n1ccc2ccncc12
Show InChI InChI=1S/C17H13N5/c18-16-9-13(4-7-20-16)14-1-2-17(21-10-14)22-8-5-12-3-6-19-11-15(12)22/h1-11H,(H2,18,20)
PDB

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0.550n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281568
PNG
(US10022461, Compound 19)
Show SMILES Cn1ccc2cc(ncc12)-n1ccc2ccncc12
Show InChI InChI=1S/C15H12N4/c1-18-6-3-12-8-15(17-10-13(12)18)19-7-4-11-2-5-16-9-14(11)19/h2-10H,1H3
PDB

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0.620n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281599
PNG
(US10022461, Compound 49)
Show SMILES Oc1cccc2cnc(cc12)-n1ccc2ccncc12
Show InChI InChI=1S/C16H11N3O/c20-15-3-1-2-12-9-18-16(8-13(12)15)19-7-5-11-4-6-17-10-14(11)19/h1-10,20H
PDB

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0.670n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281642
PNG
(US10022461, Compound 112)
Show SMILES Nc1cc(F)cc2cc(ncc12)-n1ccc2ccncc12
Show InChI InChI=1S/C16H11FN4/c17-12-5-11-6-16(20-8-13(11)14(18)7-12)21-4-2-10-1-3-19-9-15(10)21/h1-9H,18H2
PDB

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0.672n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281638
PNG
(US10022461, Compound 108)
Show SMILES Nc1ccc2cc(ncc2c1F)-n1ccc2ccncc12
Show InChI InChI=1S/C16H11FN4/c17-16-12-8-20-15(7-11(12)1-2-13(16)18)21-6-4-10-3-5-19-9-14(10)21/h1-9H,18H2
PDB

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UniChem
0.677n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281624
PNG
(US10022461, Compound 88)
Show SMILES CNc1ccc(cn1)-c1ccc(nc1)-n1ccc2ccncc12
Show InChI InChI=1S/C18H15N5/c1-19-17-4-2-14(10-21-17)15-3-5-18(22-11-15)23-9-7-13-6-8-20-12-16(13)23/h2-12H,1H3,(H,19,21)
PDB

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0.690n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281569
PNG
(US10022461, Compound 20)
Show SMILES Ic1ccc2cnc(cc2c1)-n1ccc2ccncc12
Show InChI InChI=1S/C16H10IN3/c17-14-2-1-12-9-19-16(8-13(12)7-14)20-6-4-11-3-5-18-10-15(11)20/h1-10H
PDB

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0.75n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281600
PNG
(US10022461, Compound 50)
Show SMILES Cc1cc(ncc1C#C)-n1ccc2ccncc12
Show InChI InChI=1S/C15H11N3/c1-3-12-9-17-15(8-11(12)2)18-7-5-13-4-6-16-10-14(13)18/h1,4-10H,2H3
PDB

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0.75n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281622
PNG
(US10022461, Compound 72)
Show SMILES CNc1cccc(c1)-c1ccc(nc1)-n1ccc2ccncc12
Show InChI InChI=1S/C19H16N4/c1-20-17-4-2-3-15(11-17)16-5-6-19(22-12-16)23-10-8-14-7-9-21-13-18(14)23/h2-13,20H,1H3
PDB

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0.760n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281643
PNG
(US10022461, Compound 113)
Show SMILES Nc1cc(F)c2cnc(cc2c1)-n1ccc2ccncc12
Show InChI InChI=1S/C16H11FN4/c17-14-7-12(18)5-11-6-16(20-8-13(11)14)21-4-2-10-1-3-19-9-15(10)21/h1-9H,18H2
PDB

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0.784n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281601
PNG
(US10022461, Compound 51)
Show SMILES Cc1cc(ncc1C#CCF)-n1ccc2ccncc12
Show InChI InChI=1S/C16H12FN3/c1-12-9-16(19-10-14(12)3-2-6-17)20-8-5-13-4-7-18-11-15(13)20/h4-5,7-11H,6H2,1H3
PDB

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0.870n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281628
PNG
(US10022461, Compound 95)
Show SMILES CN(C)c1ccc(cn1)-c1ccc(nc1)-n1ccc2ccncc12
Show InChI InChI=1S/C19H17N5/c1-23(2)18-5-3-15(11-21-18)16-4-6-19(22-12-16)24-10-8-14-7-9-20-13-17(14)24/h3-13H,1-2H3
PDB

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0.960n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281602
PNG
(US10022461, Compound 52)
Show SMILES CC#Cc1ccc(nc1)-n1ccc2ccncc12
Show InChI InChI=1S/C15H11N3/c1-2-3-12-4-5-15(17-10-12)18-9-7-13-6-8-16-11-14(13)18/h4-11H,1H3
PDB

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0.980n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281603
PNG
(US10022461, Compound 53)
Show SMILES c1ncc(s1)-c1ccc(nc1)-n1ccc2ccncc12
Show InChI InChI=1S/C15H10N4S/c1-2-15(18-7-12(1)14-9-17-10-20-14)19-6-4-11-3-5-16-8-13(11)19/h1-10H
PDB

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1.02n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281604
PNG
(US10022461, Compound 54)
Show SMILES Fc1cccc2cnc(cc12)-n1ccc2ccncc12
Show InChI InChI=1S/C16H10FN3/c17-14-3-1-2-12-9-19-16(8-13(12)14)20-7-5-11-4-6-18-10-15(11)20/h1-10H
PDB

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1.05n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281631
PNG
(US10022461, Compound 100)
Show SMILES Nc1ccc(cn1)-c1ccc(nc1)-n1ccc2ccncc12
Show InChI InChI=1S/C17H13N5/c18-16-3-1-13(9-20-16)14-2-4-17(21-10-14)22-8-6-12-5-7-19-11-15(12)22/h1-11H,(H2,18,20)
PDB

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1.06n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281654
PNG
(US10022461, Compound 124)
Show SMILES Nc1cc(I)cc2cc(ncc12)-n1ccc2ccncc12
Show InChI InChI=1S/C16H11IN4/c17-12-5-11-6-16(20-8-13(11)14(18)7-12)21-4-2-10-1-3-19-9-15(10)21/h1-9H,18H2
PDB

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1.07n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281641
PNG
(US10022461, Compound 111)
Show SMILES Nc1ccc2cnc(cc2c1F)-n1ccc2ccncc12
Show InChI InChI=1S/C16H11FN4/c17-16-12-7-15(20-8-11(12)1-2-13(16)18)21-6-4-10-3-5-19-9-14(10)21/h1-9H,18H2
PDB

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1.09n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281629
PNG
(US10022461, Compound 98)
Show SMILES c1cc([nH]n1)-c1ccc(nc1)-n1ccc2ccncc12
PDB

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1.13n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281597
PNG
(US10022461, Compound 44)
Show SMILES Fc1cc(ccn1)-c1ccc(nc1)-n1ccc2ccncc12
Show InChI InChI=1S/C17H11FN4/c18-16-9-13(4-7-20-16)14-1-2-17(21-10-14)22-8-5-12-3-6-19-11-15(12)22/h1-11H
PDB

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1.13n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281605
PNG
(US10022461, Compound 55)
Show SMILES FCOc1cccc2cc(ncc12)-n1ccc2ccncc12
Show InChI InChI=1S/C17H12FN3O/c18-11-22-16-3-1-2-13-8-17(20-9-14(13)16)21-7-5-12-4-6-19-10-15(12)21/h1-10H,11H2
PDB

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1.14n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281632
PNG
(US10022461, Compound 101)
Show SMILES c1cc2ccncc2n1-c1ccc(cn1)-c1ccccn1
Show InChI InChI=1S/C17H12N4/c1-2-8-19-15(3-1)14-4-5-17(20-11-14)21-10-7-13-6-9-18-12-16(13)21/h1-12H
PDB

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1.14n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281606
PNG
(US10022461, Compound 56)
Show SMILES Oc1cccc2cc(ncc12)-n1ccc2ccncc12
Show InChI InChI=1S/C16H11N3O/c20-15-3-1-2-12-8-16(18-9-13(12)15)19-7-5-11-4-6-17-10-14(11)19/h1-10,20H
PDB

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1.16n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281657
PNG
(US10022461, Compound 127)
Show SMILES Nc1cc(I)cc2cnc(cc12)-n1ccc2ccncc12
Show InChI InChI=1S/C16H11IN4/c17-12-5-11-8-20-16(7-13(11)14(18)6-12)21-4-2-10-1-3-19-9-15(10)21/h1-9H,18H2
PDB

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1.17n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281607
PNG
(US10022461, Compound 57)
Show SMILES FCOc1ccc2cnc(cc2c1)-n1ccc2ccncc12
Show InChI InChI=1S/C17H12FN3O/c18-11-22-15-2-1-13-9-20-17(8-14(13)7-15)21-6-4-12-3-5-19-10-16(12)21/h1-10H,11H2
PDB

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1.23n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281646
PNG
(US10022461, Compound 116)
Show SMILES Nc1ccc(F)c2cnc(cc12)-n1ccc2ccncc12
Show InChI InChI=1S/C16H11FN4/c17-13-1-2-14(18)11-7-16(20-8-12(11)13)21-6-4-10-3-5-19-9-15(10)21/h1-9H,18H2
PDB

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1.28n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281608
PNG
(US10022461, Compound 58)
Show SMILES Cn1cc(cn1)-c1ccc(nc1)-n1ccc2ccncc12
Show InChI InChI=1S/C16H13N5/c1-20-11-14(9-19-20)13-2-3-16(18-8-13)21-7-5-12-4-6-17-10-15(12)21/h2-11H,1H3
PDB

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1.32n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281627
PNG
(US10022461, Compound 94)
Show SMILES CCNc1cc(ccn1)-c1ccc(nc1)-n1ccc2ccncc12
Show InChI InChI=1S/C19H17N5/c1-2-21-18-11-15(6-9-22-18)16-3-4-19(23-12-16)24-10-7-14-5-8-20-13-17(14)24/h3-13H,2H2,1H3,(H,21,22)
PDB

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1.40n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281625
PNG
(US10022461, Compound 91)
Show SMILES Fc1cccc(n1)-c1ccc(nc1)-n1ccc2ccncc12
Show InChI InChI=1S/C17H11FN4/c18-16-3-1-2-14(21-16)13-4-5-17(20-10-13)22-9-7-12-6-8-19-11-15(12)22/h1-11H
PDB

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1.41n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281572
PNG
(US10022461, Compound 22)
Show SMILES CC#Cc1cnc(cc1F)-n1ccc2ccncc12
Show InChI InChI=1S/C15H10FN3/c1-2-3-12-9-18-15(8-13(12)16)19-7-5-11-4-6-17-10-14(11)19/h4-10H,1H3
PDB

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1.43n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281575
PNG
(US10022461, Compound 24-4)
Show SMILES COc1ccc2nc(ncc2c1)-n1ccc2ccncc12
Show InChI InChI=1S/C16H12N4O/c1-21-13-2-3-14-12(8-13)9-18-16(19-14)20-7-5-11-4-6-17-10-15(11)20/h2-10H,1H3
PDB

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1.55n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281556
PNG
(US10022461, Compound 7)
Show SMILES FCC#Cc1ccc(nc1)-n1ccc2ccncc12
Show InChI InChI=1S/C15H10FN3/c16-7-1-2-12-3-4-15(18-10-12)19-9-6-13-5-8-17-11-14(13)19/h3-6,8-11H,7H2
PDB

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1.65n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281634
PNG
(US10022461, Compound 104)
Show SMILES FCCn1ccc(n1)-c1ccc(nc1)-n1ccc2ccncc12
Show InChI InChI=1S/C17H14FN5/c18-6-10-22-8-5-15(21-22)14-1-2-17(20-11-14)23-9-4-13-3-7-19-12-16(13)23/h1-5,7-9,11-12H,6,10H2
PDB

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1.71n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281652
PNG
(US10022461, Compound 122)
Show SMILES Nc1ccc2cc(ncc2c1I)-n1ccc2ccncc12
Show InChI InChI=1S/C16H11IN4/c17-16-12-8-20-15(7-11(12)1-2-13(16)18)21-6-4-10-3-5-19-9-14(10)21/h1-9H,18H2
PDB

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1.77n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281647
PNG
(US10022461, Compound 117)
Show SMILES Nc1ccc(F)c2cc(ncc12)-n1ccc2ccncc12
Show InChI InChI=1S/C16H11FN4/c17-13-1-2-14(18)12-8-20-16(7-11(12)13)21-6-4-10-3-5-19-9-15(10)21/h1-9H,18H2
PDB

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2n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281610
PNG
(US10022461, Compound 60)
Show SMILES Fc1ccc(cn1)-c1ccc(nc1)-n1ccc2ccncc12
Show InChI InChI=1S/C17H11FN4/c18-16-3-1-13(9-20-16)14-2-4-17(21-10-14)22-8-6-12-5-7-19-11-15(12)22/h1-11H
PDB

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2.04n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281573
PNG
(US10022461, Compound 23)
Show SMILES Cc1cc2cnc(cc2o1)-n1ccc2ccncc12
Show InChI InChI=1S/C15H11N3O/c1-10-6-12-8-17-15(7-14(12)19-10)18-5-3-11-2-4-16-9-13(11)18/h2-9H,1H3
PDB

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2.10n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281640
PNG
(US10022461, Compound 110)
Show SMILES Nc1c(F)ccc2cc(ncc12)-n1ccc2ccncc12
Show InChI InChI=1S/C16H11FN4/c17-13-2-1-11-7-15(20-8-12(11)16(13)18)21-6-4-10-3-5-19-9-14(10)21/h1-9H,18H2
PDB

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2.15n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281598
PNG
(US10022461, Compound 46)
Show SMILES c1cc2ccncc2n1-c1ccc(cn1)-c1ccncn1
Show InChI InChI=1S/C16H11N5/c1-2-16(19-9-13(1)14-4-7-18-11-20-14)21-8-5-12-3-6-17-10-15(12)21/h1-11H
PDB

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2.19n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281611
PNG
(US10022461, Compound 61)
Show SMILES CN(C)c1ccc2cnc(cc2c1)-n1ccc2ccncc12
Show InChI InChI=1S/C18H16N4/c1-21(2)16-4-3-14-11-20-18(10-15(14)9-16)22-8-6-13-5-7-19-12-17(13)22/h3-12H,1-2H3
PDB

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2.23n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281578
PNG
(US10022461, Compound 26)
Show SMILES c1cc2ccncc2n1-c1cc2cnccc2cn1
Show InChI InChI=1S/C15H10N4/c1-4-17-10-14-11(1)3-6-19(14)15-7-13-8-16-5-2-12(13)9-18-15/h1-10H
PDB

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2.27n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281562
PNG
(US10022461, Compound 14)
Show SMILES CN(CCF)c1ccc2cnc(cc2c1)-n1ccc2ccncc12
Show InChI InChI=1S/C19H17FN4/c1-23(9-6-20)17-3-2-15-12-22-19(11-16(15)10-17)24-8-5-14-4-7-21-13-18(14)24/h2-5,7-8,10-13H,6,9H2,1H3
PDB

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2.28n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281579
PNG
(US10022461, Compound 27)
Show SMILES Nc1nccc2cnc(cc12)-n1ccc2ccncc12
Show InChI InChI=1S/C15H11N5/c16-15-12-7-14(19-8-11(12)2-5-18-15)20-6-3-10-1-4-17-9-13(10)20/h1-9H,(H2,16,18)
PDB

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2.31n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281581
PNG
(US10022461, Compound 29)
Show SMILES FCCn1ccc(n1)-c1cnc(nc1)-n1ccc2ccncc12
Show InChI InChI=1S/C16H13FN6/c17-4-8-22-6-3-14(21-22)13-9-19-16(20-10-13)23-7-2-12-1-5-18-11-15(12)23/h1-3,5-7,9-11H,4,8H2
PDB

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2.41n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281582
PNG
(US10022461, Compound 30)
Show SMILES FCC#Cc1cnc(cc1C=C)-n1ccc2ccncc12
Show InChI InChI=1S/C17H12FN3/c1-2-13-10-17(20-11-15(13)4-3-7-18)21-9-6-14-5-8-19-12-16(14)21/h2,5-6,8-12H,1,7H2
PDB

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2.44n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281612
PNG
(US10022461, Compound 62)
Show SMILES Fc1ccc2nc(ncc2c1)-n1ccc2ccncc12
Show InChI InChI=1S/C15H9FN4/c16-12-1-2-13-11(7-12)8-18-15(19-13)20-6-4-10-3-5-17-9-14(10)20/h1-9H
PDB

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2.55n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281613
PNG
(US10022461, Compound 63)
Show SMILES Cn1ccc(n1)-c1ccc(nc1)-n1ccc2ccncc12
Show InChI InChI=1S/C16H13N5/c1-20-8-6-14(19-20)13-2-3-16(18-10-13)21-9-5-12-4-7-17-11-15(12)21/h2-11H,1H3
PDB

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2.84n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281583
PNG
(US10022461, Compound 31)
Show SMILES ClCCC1CCN(CC1)c1ccc(nc1)-n1ccc2ccncc12
Show InChI InChI=1S/C19H21ClN4/c20-8-3-15-5-10-23(11-6-15)17-1-2-19(22-13-17)24-12-7-16-4-9-21-14-18(16)24/h1-2,4,7,9,12-15H,3,5-6,8,10-11H2
PDB

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2.88n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281585
PNG
(US10022461, Compound 32)
Show SMILES Cc1cc(ncc1OCCF)-n1ccc2ccncc12
Show InChI InChI=1S/C15H14FN3O/c1-11-8-15(18-10-14(11)20-7-4-16)19-6-3-12-2-5-17-9-13(12)19/h2-3,5-6,8-10H,4,7H2,1H3
PDB

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2.98n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281614
PNG
(US10022461, Compound 64)
Show SMILES c1cc2ccncc2n1-c1ccc(cn1)-c1cnccn1
Show InChI InChI=1S/C16H11N5/c1-2-16(20-9-13(1)14-10-18-6-7-19-14)21-8-4-12-3-5-17-11-15(12)21/h1-11H
PDB

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3.17n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281588
PNG
(US10022461, Compound 35)
Show SMILES FCCCNc1ccc(nc1)-n1ccc2ccncc12
Show InChI InChI=1S/C15H15FN4/c16-6-1-7-18-13-2-3-15(19-10-13)20-9-5-12-4-8-17-11-14(12)20/h2-5,8-11,18H,1,6-7H2
PDB

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3.19n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281586
PNG
(US10022461, Compound 33)
Show SMILES COc1cc(ncc1C#CC)-n1ccc2ccncc12
Show InChI InChI=1S/C16H13N3O/c1-3-4-13-10-18-16(9-15(13)20-2)19-8-6-12-5-7-17-11-14(12)19/h5-11H,1-2H3
PDB

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3.34n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281571
PNG
(US10022461, Compound 21-4)
Show SMILES CC#Cc1cnc(cc1CO)-n1ccc2ccncc12
Show InChI InChI=1S/C16H13N3O/c1-2-3-13-9-18-16(8-14(13)11-20)19-7-5-12-4-6-17-10-15(12)19/h4-10,20H,11H2,1H3
PDB

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3.35n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281615
PNG
(US10022461, Compound 65)
Show SMILES Cn1cnc(c1)-c1ccc(nc1)-n1ccc2ccncc12
Show InChI InChI=1S/C16H13N5/c1-20-10-14(19-11-20)13-2-3-16(18-8-13)21-7-5-12-4-6-17-9-15(12)21/h2-11H,1H3
PDB

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3.42n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281584
PNG
(US10022461, Compound 31-1)
Show SMILES OCCC1CCN(CC1)c1ccc(nc1)-n1ccc2ccncc12
Show InChI InChI=1S/C19H22N4O/c24-12-7-15-4-9-22(10-5-15)17-1-2-19(21-13-17)23-11-6-16-3-8-20-14-18(16)23/h1-3,6,8,11,13-15,24H,4-5,7,9-10,12H2
PDB

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3.54n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281587
PNG
(US10022461, Compound 34)
Show SMILES COc1ccc(NC(=O)c2ccc(nc2)-n2ccc3ccncc23)cc1
Show InChI InChI=1S/C20H16N4O2/c1-26-17-5-3-16(4-6-17)23-20(25)15-2-7-19(22-12-15)24-11-9-14-8-10-21-13-18(14)24/h2-13H,1H3,(H,23,25)
PDB

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3.83n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281659
PNG
(US10022461, Compound 130)
Show SMILES COc1cc2ccn(-c3cc4cc(F)ccc4cn3)c2cn1
Show InChI InChI=1S/C17H12FN3O/c1-22-17-8-11-4-5-21(15(11)10-20-17)16-7-13-6-14(18)3-2-12(13)9-19-16/h2-10H,1H3
PDB

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4.03n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281616
PNG
(US10022461, Compound 66)
Show SMILES CN(CCO)c1ccc2cnc(cc2c1)-n1ccc2ccncc12
Show InChI InChI=1S/C19H18N4O/c1-22(8-9-24)17-3-2-15-12-21-19(11-16(15)10-17)23-7-5-14-4-6-20-13-18(14)23/h2-7,10-13,24H,8-9H2,1H3
PDB

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4.07n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281570
PNG
(US10022461, Compound 21)
Show SMILES CC#Cc1cnc(cc1CF)-n1ccc2ccncc12
Show InChI InChI=1S/C16H12FN3/c1-2-3-13-10-19-16(8-14(13)9-17)20-7-5-12-4-6-18-11-15(12)20/h4-8,10-11H,9H2,1H3
PDB

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4.10n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281589
PNG
(US10022461, Compound 36)
Show SMILES FCCNc1ccc(nc1)-n1ccc2ccncc12
Show InChI InChI=1S/C14H13FN4/c15-5-7-17-12-1-2-14(18-9-12)19-8-4-11-3-6-16-10-13(11)19/h1-4,6,8-10,17H,5,7H2
PDB

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4.96n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281658
PNG
(US10022461, Compound 128)
Show SMILES Nc1cc(I)c2cc(ncc2c1)-n1ccc2ccncc12
Show InChI InChI=1S/C16H11IN4/c17-14-6-12(18)5-11-8-20-16(7-13(11)14)21-4-2-10-1-3-19-9-15(10)21/h1-9H,18H2
PDB

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6.21n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281617
PNG
(US10022461, Compound 67)
Show SMILES FCCOc1cccc2cc(ncc12)-n1ccc2ccncc12
Show InChI InChI=1S/C18H14FN3O/c19-6-9-23-17-3-1-2-14-10-18(21-11-15(14)17)22-8-5-13-4-7-20-12-16(13)22/h1-5,7-8,10-12H,6,9H2
PDB

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6.75n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281618
PNG
(US10022461, Compound 68)
Show SMILES Fc1ccc2cnc(nc2c1)-n1ccc2ccncc12
Show InChI InChI=1S/C15H9FN4/c16-12-2-1-11-8-18-15(19-13(11)7-12)20-6-4-10-3-5-17-9-14(10)20/h1-9H
PDB

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8.45n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281594
PNG
(US10022461, Compound 41)
Show SMILES c1nc(n[nH]1)-c1ccc(nc1)-n1ccc2ccncc12
PDB

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8.80n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281619
PNG
(US10022461, Compound 69)
Show SMILES FCCOc1ccc2nc(ncc2c1)-n1ccc2ccncc12
Show InChI InChI=1S/C17H13FN4O/c18-5-8-23-14-1-2-15-13(9-14)10-20-17(21-15)22-7-4-12-3-6-19-11-16(12)22/h1-4,6-7,9-11H,5,8H2
PDB

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9.33n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281596
PNG
(US10022461, Compound 43)
Show SMILES FC1CCN(CC1)c1ccc(nc1)-n1ccc2ccncc12
Show InChI InChI=1S/C17H17FN4/c18-14-5-8-21(9-6-14)15-1-2-17(20-11-15)22-10-4-13-3-7-19-12-16(13)22/h1-4,7,10-12,14H,5-6,8-9H2
PDB

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10n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281592
PNG
(US10022461, Compound 39)
Show SMILES C1CNc2cc(ncc2C1)-n1ccc2ccncc12
Show InChI InChI=1S/C15H14N4/c1-2-12-9-18-15(8-13(12)17-5-1)19-7-4-11-3-6-16-10-14(11)19/h3-4,6-10,17H,1-2,5H2
PDB

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10.8n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281576
PNG
(US10022461, Compound 24-5)
Show SMILES Oc1ccc2nc(ncc2c1)-n1ccc2ccncc12
Show InChI InChI=1S/C15H10N4O/c20-12-1-2-13-11(7-12)8-17-15(18-13)19-6-4-10-3-5-16-9-14(10)19/h1-9,20H
PDB

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11.1n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281574
PNG
(US10022461, Compound 24)
Show SMILES FCOc1ccc2nc(ncc2c1)-n1ccc2ccncc12
Show InChI InChI=1S/C16H11FN4O/c17-10-22-13-1-2-14-12(7-13)8-19-16(20-14)21-6-4-11-3-5-18-9-15(11)21/h1-9H,10H2
PDB

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12.8n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281577
PNG
(US10022461, Compound 25)
Show SMILES Fc1nccc2cnc(cc12)-n1ccc2ccncc12
Show InChI InChI=1S/C15H9FN4/c16-15-12-7-14(19-8-11(12)2-5-18-15)20-6-3-10-1-4-17-9-13(10)20/h1-9H
PDB

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14.1n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281655
PNG
(US10022461, Compound 125)
Show SMILES Nc1cc(I)c2cnc(cc2c1)-n1ccc2ccncc12
Show InChI InChI=1S/C16H11IN4/c17-14-7-12(18)5-11-6-16(20-8-13(11)14)21-4-2-10-1-3-19-9-15(10)21/h1-9H,18H2
PDB

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18.6n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281590
PNG
(US10022461, Compound 37)
Show SMILES Fc1nc(ccc1-c1cccnc1)-n1ccc2ccncc12
Show InChI InChI=1S/C17H11FN4/c18-17-14(13-2-1-7-19-10-13)3-4-16(21-17)22-9-6-12-5-8-20-11-15(12)22/h1-11H
PDB

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19.7n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281648
PNG
(US10022461, Compound 118)
Show SMILES Nc1ccc2cnc(cc2c1I)-n1ccc2ccncc12
Show InChI InChI=1S/C16H11IN4/c17-16-12-7-15(20-8-11(12)1-2-13(16)18)21-6-4-10-3-5-19-9-14(10)21/h1-9H,18H2
PDB

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24.5n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281620
PNG
(US10022461, Compound 70)
Show SMILES COc1cccc2cnc(cc12)-n1ccc2ccncc12
Show InChI InChI=1S/C17H13N3O/c1-21-16-4-2-3-13-10-19-17(9-14(13)16)20-8-6-12-5-7-18-11-15(12)20/h2-11H,1H3
PDB

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44.4n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281591
PNG
(US10022461, Compound 38)
Show SMILES Fc1cc2ccn(-c3cc4ccccc4cn3)c2cn1
Show InChI InChI=1S/C16H10FN3/c17-15-7-12-5-6-20(14(12)10-18-15)16-8-11-3-1-2-4-13(11)9-19-16/h1-10H
PDB

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52.3n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281593
PNG
(US10022461, Compound 40)
Show SMILES Fc1ccc2cnc(cc2n1)-n1ccc2ccncc12
Show InChI InChI=1S/C15H9FN4/c16-14-2-1-11-8-18-15(7-12(11)19-14)20-6-4-10-3-5-17-9-13(10)20/h1-9H
PDB

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52.7n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281595
PNG
(US10022461, Compound 42)
Show SMILES OC1CCN(CC1)c1ccc(nc1)-n1ccc2ccncc12
Show InChI InChI=1S/C17H18N4O/c22-15-5-8-20(9-6-15)14-1-2-17(19-11-14)21-10-4-13-3-7-18-12-16(13)21/h1-4,7,10-12,15,22H,5-6,8-9H2
PDB

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71.1n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281650
PNG
(US10022461, Compound 120)
Show SMILES Nc1ccc(I)c2cc(ncc12)-n1ccc2ccncc12
Show InChI InChI=1S/C16H11IN4/c17-13-1-2-14(18)12-8-20-16(7-11(12)13)21-6-4-10-3-5-19-9-15(10)21/h1-9H,18H2
PDB

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93.8n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281621
PNG
(US10022461, Compound 71)
Show SMILES FCCOc1cccc2cnc(cc12)-n1ccc2ccncc12
Show InChI InChI=1S/C18H14FN3O/c19-6-9-23-17-3-1-2-14-11-21-18(10-15(14)17)22-8-5-13-4-7-20-12-16(13)22/h1-5,7-8,10-12H,6,9H2
PDB

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172n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281580
PNG
(US10022461, Compound 28)
Show SMILES COc1nccc2cnc(cc12)-n1ccc2ccncc12
Show InChI InChI=1S/C16H12N4O/c1-21-16-13-8-15(19-9-12(13)3-6-18-16)20-7-4-11-2-5-17-10-14(11)20/h2-10H,1H3
PDB

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185n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281653
PNG
(US10022461, Compound 123)
Show SMILES Nc1ccc(I)c2cnc(cc12)-n1ccc2ccncc12
Show InChI InChI=1S/C16H11IN4/c17-13-1-2-14(18)11-7-16(20-8-12(11)13)21-6-4-10-3-5-19-9-15(10)21/h1-9H,18H2
PDB

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208n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281636
PNG
(US10022461, Compound 106)
Show SMILES Nc1cccc2cnc(cc12)-n1ccc2cc(F)ncc12
Show InChI InChI=1S/C16H11FN4/c17-15-6-10-4-5-21(14(10)9-19-15)16-7-12-11(8-20-16)2-1-3-13(12)18/h1-9H,18H2
PDB

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1.00E+4n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281637
PNG
(US10022461, Compound 107)
Show SMILES Nc1cccc2cnc(cc12)-n1ccc2ccnc(F)c12
Show InChI InChI=1S/C16H11FN4/c17-16-15-10(4-6-19-16)5-7-21(15)14-8-12-11(9-20-14)2-1-3-13(12)18/h1-9H,18H2
PDB

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1.00E+4n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%