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Patent code US10023543

Compile Data Set for Download or QSAR
Found 122 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283224
PNG
(4-[2-(4-amino-piperidin-1-yl)-5- cyclopentylethyny...)
Show SMILES Cn1c(nc(-c2ccc(C#N)c(F)c2)c(C#CC2CCCC2)c1=O)N1CCC(N)CC1
Show InChI InChI=1S/C24H26FN5O/c1-29-23(31)20(9-6-16-4-2-3-5-16)22(17-7-8-18(15-26)21(25)14-17)28-24(29)30-12-10-19(27)11-13-30/h7-8,14,16,19H,2-5,10-13,27H2,1H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283231
PNG
(2-(4-amino-piperidin-1-yl)-4-(4- cyano-3-fluoro-ph...)
Show SMILES Cn1c(nc(-c2ccc(C#N)c(F)c2)c(C#N)c1=O)N1CCC(N)CC1
Show InChI InChI=1S/C18H17FN6O/c1-24-17(26)14(10-21)16(11-2-3-12(9-20)15(19)8-11)23-18(24)25-6-4-13(22)5-7-25/h2-3,8,13H,4-7,22H2,1H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283238
PNG
(4-[2-(4-aminopiperidyl)-5-(5- fluoro-6-methoxy(3-5...)
Show SMILES COc1ncc(cc1F)-c1c(nc(N2CCC(N)CC2)n(C)c1=O)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C23H22F2N6O2/c1-30-22(32)19(15-10-18(25)21(33-2)28-12-15)20(13-3-4-14(11-26)17(24)9-13)29-23(30)31-7-5-16(27)6-8-31/h3-4,9-10,12,16H,5-8,27H2,1-2H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283249
PNG
(4-{2-(4-amino-piperidin-1-yl)-1- methyl-6-oxo-5-[1...)
Show SMILES Cn1c(nc(-c2ccc(C#N)c(F)c2)c(-c2cnn(CC(F)(F)F)c2)c1=O)N1CCC(N)CC1
Show InChI InChI=1S/C22H21F4N7O/c1-31-20(34)18(15-10-29-33(11-15)12-22(24,25)26)19(13-2-3-14(9-27)17(23)8-13)30-21(31)32-6-4-16(28)5-7-32/h2-3,8,10-11,16H,4-7,12,28H2,1H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283274
PNG
(4-[2-(4-amino-piperidin-1-yl)-5- (6-dimethylamino-...)
Show SMILES CN(C)c1ccc(cn1)-c1c(nc(N2CCC(N)CC2)n(C)c1=O)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C24H26FN7O/c1-30(2)20-7-6-17(14-28-20)21-22(15-4-5-16(13-26)19(25)12-15)29-24(31(3)23(21)33)32-10-8-18(27)9-11-32/h4-7,12,14,18H,8-11,27H2,1-3H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283275
PNG
(2-fluoro-4-[5-(6-methoxy-pyridin-3- yl)-1-methyl-2...)
Show SMILES CNC1CCN(CC1)c1nc(-c2ccc(C#N)c(F)c2)c(-c2ccc(OC)nc2)c(=O)n1C
Show InChI InChI=1S/C24H25FN6O2/c1-27-18-8-10-31(11-9-18)24-29-22(15-4-5-16(13-26)19(25)12-15)21(23(32)30(24)2)17-6-7-20(33-3)28-14-17/h4-7,12,14,18,27H,8-11H2,1-3H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283289
PNG
(2-fluoro-4-[5-(4-methoxy-phenyl)- 1-methyl-2-(3-me...)
Show SMILES CNCC1CN(C1)c1nc(-c2ccc(C#N)c(F)c2)c(-c2ccc(OC)cc2)c(=O)n1C
Show InChI InChI=1S/C24H24FN5O2/c1-27-12-15-13-30(14-15)24-28-22(17-4-5-18(11-26)20(25)10-17)21(23(31)29(24)2)16-6-8-19(32-3)9-7-16/h4-10,15,27H,12-14H2,1-3H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283297
PNG
(4-[2-((4R,3S)-4-amino-3-fluoro- piperidin-1-yl)-5-...)
Show SMILES COc1ccc(cc1)-c1c(nc(N2CC[C@@H](N)[C@@H](F)C2)n(C)c1=O)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C24H23F2N5O2/c1-30-23(32)21(14-5-7-17(33-2)8-6-14)22(15-3-4-16(12-27)18(25)11-15)29-24(30)31-10-9-20(28)19(26)13-31/h3-8,11,19-20H,9-10,13,28H2,1-2H3/t19-,20+/m0/s1
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283129
PNG
(4-[2-(4-amino-piperidin-1-yl)-5- (4-methoxyphenyl)...)
Show SMILES COc1ccc(cc1)-c1c(nc(N2CCC(N)CC2)n(C)c1=O)-c1ccc(cc1)C#N
Show InChI InChI=1S/C24H25N5O2/c1-28-23(30)21(17-7-9-20(31-2)10-8-17)22(18-5-3-16(15-25)4-6-18)27-24(28)29-13-11-19(26)12-14-29/h3-10,19H,11-14,26H2,1-2H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283199
PNG
(4-[2-(4-amino-piperidin-1-yl)-1- methyl-5-(6-methy...)
Show SMILES Cc1ccc(cn1)-c1c(nc(N2CCC(N)CC2)n(C)c1=O)-c1ccc(cc1)C#N
Show InChI InChI=1S/C23H24N6O/c1-15-3-6-18(14-26-15)20-21(17-7-4-16(13-24)5-8-17)27-23(28(2)22(20)30)29-11-9-19(25)10-12-29/h3-8,14,19H,9-12,25H2,1-2H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283217
PNG
(4-[2-(4-amino-piperidin-1-yl)-5- (6-methoxypyridin...)
Show SMILES COc1ccc(cn1)-c1c(nc(N2CCC(N)CC2)n(C)c1=O)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C23H23FN6O2/c1-29-22(31)20(16-5-6-19(32-2)27-13-16)21(14-3-4-15(12-25)18(24)11-14)28-23(29)30-9-7-17(26)8-10-30/h3-6,11,13,17H,7-10,26H2,1-2H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283242
PNG
(4-[2-((3S)-3-amino-pyrrolidin-1-yl)- 5-(3-fluoro-4...)
Show SMILES COc1ccc(cc1F)-c1c(nc(N2CC[C@H](N)C2)n(C)c1=O)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C23H21F2N5O2/c1-29-22(31)20(13-5-6-19(32-2)18(25)9-13)21(14-3-4-15(11-26)17(24)10-14)28-23(29)30-8-7-16(27)12-30/h3-6,9-10,16H,7-8,12,27H2,1-2H3/t16-/m0/s1
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283246
PNG
(4-[2-(4-amino-4-methyl-piperidin- 1-yl)-5-(3-fluor...)
Show SMILES COc1ccc(cc1F)-c1c(nc(N2CCC(C)(N)CC2)n(C)c1=O)-c1ccc([N+]#[C-])c(F)c1
Show InChI InChI=1S/C25H25F2N5O2/c1-25(28)9-11-32(12-10-25)24-30-22(16-5-7-19(29-2)17(26)14-16)21(23(33)31(24)3)15-6-8-20(34-4)18(27)13-15/h5-8,13-14H,9-12,28H2,1,3-4H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283261
PNG
(4-{5-(3-fluoro-4-methoxy-phenyl)- 1-methyl-6-oxo-2...)
Show SMILES COc1ccc(cc1F)-c1c(nc(NC[C@@H]2CCNC2)n(C)c1=O)-c1ccc(cc1)C#N
Show InChI InChI=1S/C24H24FN5O2/c1-30-23(31)21(18-7-8-20(32-2)19(25)11-18)22(17-5-3-15(12-26)4-6-17)29-24(30)28-14-16-9-10-27-13-16/h3-8,11,16,27H,9-10,13-14H2,1-2H3,(H,28,29)/t16-/m1/s1
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283263
PNG
(4-[2-[1,4]diazepan-1-yl-5-(3-fluoro- 4-methoxy-phe...)
Show SMILES COc1ccc(cc1F)-c1c(nc(N2CCCNCC2)n(C)c1=O)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C24H23F2N5O2/c1-30-23(32)21(15-6-7-20(33-2)19(26)12-15)22(16-4-5-17(14-27)18(25)13-16)29-24(30)31-10-3-8-28-9-11-31/h4-7,12-13,28H,3,8-11H2,1-2H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283286
PNG
(4-[2-(3-aminomethyl-azetidin-1-yl)- 5-(4-methoxy-p...)
Show SMILES COc1ccc(cc1)-c1c(nc(N2CC(CN)C2)n(C)c1=O)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C23H22FN5O2/c1-28-22(30)20(15-5-7-18(31-2)8-6-15)21(16-3-4-17(11-26)19(24)9-16)27-23(28)29-12-14(10-25)13-29/h3-9,14H,10,12-13,25H2,1-2H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283293
PNG
(4-[2-(4-amino-piperidin-1-yl)-1- methyl-5-(1-methy...)
Show SMILES Cn1ccc2cc(ccc12)-c1c(nc(N2CCC(N)CC2)n(C)c1=O)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C26H25FN6O/c1-31-10-7-16-13-17(5-6-22(16)31)23-24(18-3-4-19(15-28)21(27)14-18)30-26(32(2)25(23)34)33-11-8-20(29)9-12-33/h3-7,10,13-14,20H,8-9,11-12,29H2,1-2H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283296
PNG
(4-[2-(4-amino-piperidin-1-yl)-5- (1H-indazol-6-yl)...)
Show SMILES Cn1c(nc(-c2ccc(C#N)c(F)c2)c(-c2ccc3cn[nH]c3c2)c1=O)N1CCC(N)CC1
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283298
PNG
(4-[2-((4S,3R)-4-amino-3-fluoro- piperidin-1-yl)-5-...)
Show SMILES COc1ccc(cc1)-c1c(nc(N2CC[C@H](N)[C@H](F)C2)n(C)c1=O)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C24H23F2N5O2/c1-30-23(32)21(14-5-7-17(33-2)8-6-14)22(15-3-4-16(12-27)18(25)11-15)29-24(30)31-10-9-20(28)19(26)13-31/h3-8,11,19-20H,9-10,13,28H2,1-2H3/t19-,20+/m1/s1
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283300
PNG
(4-[2'-dimethylamino-2-(4- dimethylamino-piperidin-...)
Show SMILES CN(C)C1CCN(CC1)c1nc(-c2ccc(C#N)c(F)c2)c(-c2cnc(nc2)N(C)C)c(=O)n1C
Show InChI InChI=1S/C25H29FN8O/c1-31(2)19-8-10-34(11-9-19)25-30-22(16-6-7-17(13-27)20(26)12-16)21(23(35)33(25)5)18-14-28-24(29-15-18)32(3)4/h6-7,12,14-15,19H,8-11H2,1-5H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283301
PNG
(4-[2-(4-dimethylamino-piperidin-1- yl)-1-methyl-5-...)
Show SMILES CN(C)C1CCN(CC1)c1nc(-c2ccc(C#N)c(F)c2)c(-c2ccc(C)nc2)c(=O)n1C
Show InChI InChI=1S/C25H27FN6O/c1-16-5-6-19(15-28-16)22-23(17-7-8-18(14-27)21(26)13-17)29-25(31(4)24(22)33)32-11-9-20(10-12-32)30(2)3/h5-8,13,15,20H,9-12H2,1-4H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283302
PNG
(4-[5-(6-dimethylamino-pyridin-3- yl)-1-methyl-2-(4...)
Show SMILES CNC1CCN(CC1)c1nc(-c2ccc(C#N)c(F)c2)c(-c2ccc(nc2)N(C)C)c(=O)n1C
Show InChI InChI=1S/C25H28FN7O/c1-28-19-9-11-33(12-10-19)25-30-23(16-5-6-17(14-27)20(26)13-16)22(24(34)32(25)4)18-7-8-21(29-15-18)31(2)3/h5-8,13,15,19,28H,9-12H2,1-4H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283216
PNG
(4-[2-(4-amino-piperidin-1-yl)-5- (3-fluoro-4-metho...)
Show SMILES COc1ccc(cc1F)-c1c(nc(N2CCC(N)CC2)n(C)c1=O)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C24H23F2N5O2/c1-30-23(32)21(14-5-6-20(33-2)19(26)11-14)22(15-3-4-16(13-27)18(25)12-15)29-24(30)31-9-7-17(28)8-10-31/h3-6,11-12,17H,7-10,28H2,1-2H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283216
PNG
(4-[2-(4-amino-piperidin-1-yl)-5- (3-fluoro-4-metho...)
Show SMILES COc1ccc(cc1F)-c1c(nc(N2CCC(N)CC2)n(C)c1=O)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C24H23F2N5O2/c1-30-23(32)21(14-5-6-20(33-2)19(26)11-14)22(15-3-4-16(13-27)18(25)12-15)29-24(30)31-9-7-17(28)8-10-31/h3-6,11-12,17H,7-10,28H2,1-2H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283220
PNG
(4-[2-(4-amino-piperidin-1-yl)-5-(6- ethyl-pyridin-...)
Show SMILES CCc1ccc(cn1)-c1c(nc(N2CCC(N)CC2)n(C)c1=O)-c1ccc(cc1)C#N
Show InChI InChI=1S/C24H26N6O/c1-3-20-9-8-18(15-27-20)21-22(17-6-4-16(14-25)5-7-17)28-24(29(2)23(21)31)30-12-10-19(26)11-13-30/h4-9,15,19H,3,10-13,26H2,1-2H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283226
PNG
(2-[2-(4-amino-piperidin-1-yl)-4- (4-cyano-3-fluoro...)
Show SMILES COc1ccc(cc1)-c1c(nc(N2CCC(N)CC2)n(CC(N)=O)c1=O)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C25H25FN6O3/c1-35-19-6-4-15(5-7-19)22-23(16-2-3-17(13-27)20(26)12-16)30-25(31-10-8-18(28)9-11-31)32(24(22)34)14-21(29)33/h2-7,12,18H,8-11,14,28H2,1H3,(H2,29,33)
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283232
PNG
(4-[2-(4-aminopiperidin-1-yl)-5- chloro-1-methyl-6-...)
Show SMILES Cn1c(nc(-c2ccc(C#N)c(F)c2)c(Cl)c1=O)N1CCC(N)CC1
Show InChI InChI=1S/C17H17ClFN5O/c1-23-16(25)14(18)15(10-2-3-11(9-20)13(19)8-10)22-17(23)24-6-4-12(21)5-7-24/h2-3,8,12H,4-7,21H2,1H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283237
PNG
(4-[2-((3R)-3-aminopiperidyl)-5- (3-fluoro-4-methox...)
Show SMILES COc1ccc(cc1F)-c1c(nc(N2CCC[C@@H](N)C2)n(C)c1=O)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C24H23F2N5O2/c1-30-23(32)21(14-7-8-20(33-2)19(26)10-14)22(15-5-6-16(12-27)18(25)11-15)29-24(30)31-9-3-4-17(28)13-31/h5-8,10-11,17H,3-4,9,13,28H2,1-2H3/t17-/m1/s1
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283243
PNG
(4-[2-((3R)-3-aminopiperidyl)-5- (4-methoxyphenyl)-...)
Show SMILES COc1ccc(cc1)-c1c(nc(N2CCC[C@@H](N)C2)n(C)c1=O)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C24H24FN5O2/c1-29-23(31)21(15-7-9-19(32-2)10-8-15)22(16-5-6-17(13-26)20(25)12-16)28-24(29)30-11-3-4-18(27)14-30/h5-10,12,18H,3-4,11,14,27H2,1-2H3/t18-/m1/s1
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283251
PNG
(4-{2-(4-amino-piperidin-1-yl)-1- methyl-6-oxo-5-[1...)
Show SMILES Cn1c(nc(-c2ccc(cc2)C#N)c(-c2cnn(CC(F)(F)F)c2)c1=O)N1CCC(N)CC1
Show InChI InChI=1S/C22H22F3N7O/c1-30-20(33)18(16-11-28-32(12-16)13-22(23,24)25)19(15-4-2-14(10-26)3-5-15)29-21(30)31-8-6-17(27)7-9-31/h2-5,11-12,17H,6-9,13,27H2,1H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283252
PNG
(4-[2-(4-aminopiperidyl)-1-methyl- 5-(2-methyl(2H-i...)
Show SMILES Cn1cc2cc(ccc2n1)-c1c(nc(N2CCC(N)CC2)n(C)c1=O)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C25H24FN7O/c1-31-14-18-11-15(5-6-21(18)30-31)22-23(16-3-4-17(13-27)20(26)12-16)29-25(32(2)24(22)34)33-9-7-19(28)8-10-33/h3-6,11-12,14,19H,7-10,28H2,1-2H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283280
PNG
(4-[2-[1,4]diazepan-1-yl-5- (6-dimethylamino-pyridi...)
Show SMILES CN(C)c1ccc(cn1)-c1c(nc(N2CCCNCC2)n(C)c1=O)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C24H26FN7O/c1-30(2)20-8-7-18(15-28-20)21-22(16-5-6-17(14-26)19(25)13-16)29-24(31(3)23(21)33)32-11-4-9-27-10-12-32/h5-8,13,15,27H,4,9-12H2,1-3H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283281
PNG
(4-[2-(3-amino-azetidin-1-yl)-5- (4-methoxy-phenyl)...)
Show SMILES COc1ccc(cc1)-c1c(nc(N2CC(N)C2)n(C)c1=O)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C22H20FN5O2/c1-27-21(29)19(13-5-7-17(30-2)8-6-13)20(26-22(27)28-11-16(25)12-28)14-3-4-15(10-24)18(23)9-14/h3-9,16H,11-12,25H2,1-2H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283305
PNG
(4-[2-(4-dimethylamino-piperidin-1- yl)-5-(2H-indaz...)
Show SMILES CN(C)C1CCN(CC1)c1nc(-c2ccc(C#N)c(F)c2)c(-c2ccc3cn[nH]c3c2)c(=O)n1C
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283316
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-(6- ethoxy-5-fluoro...)
Show SMILES CCOc1ncc(cc1F)-c1c(nc(N2CCC(N)CC2)n(C)c1=O)-c1ccc([N+]#[C-])c(F)c1
Show InChI InChI=1S/C24H24F2N6O2/c1-4-34-22-18(26)12-15(13-29-22)20-21(14-5-6-19(28-2)17(25)11-14)30-24(31(3)23(20)33)32-9-7-16(27)8-10-32/h5-6,11-13,16H,4,7-10,27H2,1,3H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283318
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-(4- ethoxyphenyl)-1...)
Show SMILES CCOc1ccc(cc1)-c1c(nc(N2CCC(N)CC2)n(C)c1=O)-c1ccc([N+]#[C-])c(F)c1
Show InChI InChI=1S/C25H26FN5O2/c1-4-33-19-8-5-16(6-9-19)22-23(17-7-10-21(28-2)20(26)15-17)29-25(30(3)24(22)32)31-13-11-18(27)12-14-31/h5-10,15,18H,4,11-14,27H2,1,3H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283324
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-(4- fluorophenyl)-1...)
Show SMILES Cn1c(nc(-c2ccc([N+]#[C-])c(F)c2)c(-c2ccc(F)cc2)c1=O)N1CCC(N)CC1
Show InChI InChI=1S/C23H21F2N5O/c1-27-19-8-5-15(13-18(19)25)21-20(14-3-6-16(24)7-4-14)22(31)29(2)23(28-21)30-11-9-17(26)10-12-30/h3-8,13,17H,9-12,26H2,2H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283325
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-(3- fluorophenyl)-1...)
Show SMILES Cn1c(nc(-c2ccc([N+]#[C-])c(F)c2)c(-c2cccc(F)c2)c1=O)N1CCC(N)CC1
Show InChI InChI=1S/C23H21F2N5O/c1-27-19-7-6-15(13-18(19)25)21-20(14-4-3-5-16(24)12-14)22(31)29(2)23(28-21)30-10-8-17(26)9-11-30/h3-7,12-13,17H,8-11,26H2,2H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283200
PNG
(4-[2-(4-amino-piperidin-1-yl)-5-(4- methoxyphenyl)...)
Show SMILES COc1ccc(cc1F)-c1c(nc(N2CCC(N)CC2)n(C)c1=O)-c1ccc(cc1)C#N
Show InChI InChI=1S/C24H24FN5O2/c1-29-23(31)21(17-7-8-20(32-2)19(25)13-17)22(16-5-3-15(14-26)4-6-16)28-24(29)30-11-9-18(27)10-12-30/h3-8,13,18H,9-12,27H2,1-2H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283215
PNG
(4-[2-(4-amino-piperidin-1-yl)-5- (4-methoxyphenyl)...)
Show SMILES COc1ccc(cc1)-c1c(nc(N2CCC(N)CC2)n(C)c1=O)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C24H24FN5O2/c1-29-23(31)21(15-5-7-19(32-2)8-6-15)22(16-3-4-17(14-26)20(25)13-16)28-24(29)30-11-9-18(27)10-12-30/h3-8,13,18H,9-12,27H2,1-2H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283225
PNG
(US10023543, Example 15 | [2-(4-amino-piperidin-1-y...)
Show SMILES COc1ccc(cc1)-c1c(nc(N2CCC(N)CC2)n(CC(O)=O)c1=O)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C25H24FN5O4/c1-35-19-6-4-15(5-7-19)22-23(16-2-3-17(13-27)20(26)12-16)29-25(30-10-8-18(28)9-11-30)31(24(22)34)14-21(32)33/h2-7,12,18H,8-11,14,28H2,1H3,(H,32,33)
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283233
PNG
(2-fluoro-4-[1-methyl-2- (4-methylamino-piperidin-1...)
Show SMILES CNC1CCN(CC1)c1nc(-c2ccc(C#N)c(F)c2)c(-c2ccc(C)nc2)c(=O)n1C
Show InChI InChI=1S/C24H25FN6O/c1-15-4-5-18(14-28-15)21-22(16-6-7-17(13-26)20(25)12-16)29-24(30(3)23(21)32)31-10-8-19(27-2)9-11-31/h4-7,12,14,19,27H,8-11H2,1-3H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283247
PNG
(4-[2-(4-aminopiperidyl)-1-methyl- 5-(1-methyl(1H-i...)
Show SMILES Cn1ncc2cc(ccc12)-c1c(nc(N2CCC(N)CC2)n(C)c1=O)-c1ccc(cc1)C#N
Show InChI InChI=1S/C25H25N7O/c1-30-24(33)22(18-7-8-21-19(13-18)15-28-31(21)2)23(17-5-3-16(14-26)4-6-17)29-25(30)32-11-9-20(27)10-12-32/h3-8,13,15,20H,9-12,27H2,1-2H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283258
PNG
(4-[2-(4-amino-piperidin-1-yl)-1- methyl-6-oxo-5-(1...)
Show SMILES Cn1c(nc(-c2ccc(C#N)c(F)c2)c(-c2ccc3C(=O)NCc3c2)c1=O)N1CCC(N)CC1
Show InChI InChI=1S/C25H23FN6O2/c1-31-24(34)21(14-4-5-19-17(10-14)13-29-23(19)33)22(15-2-3-16(12-27)20(26)11-15)30-25(31)32-8-6-18(28)7-9-32/h2-5,10-11,18H,6-9,13,28H2,1H3,(H,29,33)
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283260
PNG
(4-{5-(3-fluoro-4-methoxy-phenyl)- 1-methyl-6-oxo-2...)
Show SMILES COc1ccc(cc1F)-c1c(nc(NC[C@H]2CCNC2)n(C)c1=O)-c1ccc(cc1)C#N
Show InChI InChI=1S/C24H24FN5O2/c1-30-23(31)21(18-7-8-20(32-2)19(25)11-18)22(17-5-3-15(12-26)4-6-17)29-24(30)28-14-16-9-10-27-13-16/h3-8,11,16,27H,9-10,13-14H2,1-2H3,(H,28,29)/t16-/m0/s1
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283265
PNG
(4-[5-(3-fluoro-4-methoxy-phenyl)- 1-methyl-6-oxo-2...)
Show SMILES COc1ccc(cc1F)-c1c(nc(NC2CCNCC2)n(C)c1=O)-c1ccc(cc1)C#N
Show InChI InChI=1S/C24H24FN5O2/c1-30-23(31)21(17-7-8-20(32-2)19(25)13-17)22(16-5-3-15(14-26)4-6-16)29-24(30)28-18-9-11-27-12-10-18/h3-8,13,18,27H,9-12H2,1-2H3,(H,28,29)
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283268
PNG
(2-fluoro-4-{5-(4-methoxy-phenyl)- 1-methyl-6-oxo-2...)
Show SMILES COc1ccc(cc1)-c1c(nc(NC[C@H]2CCNC2)n(C)c1=O)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C24H24FN5O2/c1-30-23(31)21(16-5-7-19(32-2)8-6-16)22(17-3-4-18(12-26)20(25)11-17)29-24(30)28-14-15-9-10-27-13-15/h3-8,11,15,27H,9-10,13-14H2,1-2H3,(H,28,29)/t15-/m0/s1
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283279
PNG
(4-[2-[1,4]diazepan-1-yl-5-(6- methoxy-pyridin-3-yl...)
Show SMILES COc1ccc(cn1)-c1c(nc(N2CCCNCC2)n(C)c1=O)-c1ccc(cc1)C#N
Show InChI InChI=1S/C23H24N6O2/c1-28-22(30)20(18-8-9-19(31-2)26-15-18)21(17-6-4-16(14-24)5-7-17)27-23(28)29-12-3-10-25-11-13-29/h4-9,15,25H,3,10-13H2,1-2H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283311
PNG
(4-[5-(4-aminophenyl)-2-(4- aminopiperidin-1-yl)-1-...)
Show SMILES Cn1c(nc(-c2ccc([N+]#[C-])c(F)c2)c(-c2ccc(N)cc2)c1=O)N1CCC(N)CC1
Show InChI InChI=1S/C23H23FN6O/c1-27-19-8-5-15(13-18(19)24)21-20(14-3-6-16(25)7-4-14)22(31)29(2)23(28-21)30-11-9-17(26)10-12-30/h3-8,13,17H,9-12,25-26H2,2H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283313
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-[3- fluoro-4-(methy...)
Show SMILES CNc1ccc(cc1F)-c1c(nc(N2CCC(N)CC2)n(C)c1=O)-c1ccc([N+]#[C-])c(F)c1
Show InChI InChI=1S/C24H24F2N6O/c1-28-19-6-4-14(12-17(19)25)21-22(15-5-7-20(29-2)18(26)13-15)30-24(31(3)23(21)33)32-10-8-16(27)9-11-32/h4-7,12-13,16,28H,8-11,27H2,1,3H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283333
PNG
(4-[2-(4-amino-piperidin-1-yl)-1- cyclopropylmethyl...)
Show SMILES Cn1c(nc(-c2ccc(C#N)c(F)c2)c(C#C)c1=O)N1CCC(N)CC1
Show InChI InChI=1S/C19H18FN5O/c1-3-15-17(12-4-5-13(11-21)16(20)10-12)23-19(24(2)18(15)26)25-8-6-14(22)7-9-25/h1,4-5,10,14H,6-9,22H2,2H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283128
PNG
(4-(2-(4-aminopiperidin-1-yl)- 1-methyl-6-oxo-5-p-t...)
Show SMILES Cc1ccc(cc1)-c1c(nc(N2CCC(N)CC2)n(C)c1=O)-c1ccc(cc1)C#N
Show InChI InChI=1S/C24H25N5O/c1-16-3-7-18(8-4-16)21-22(19-9-5-17(15-25)6-10-19)27-24(28(2)23(21)30)29-13-11-20(26)12-14-29/h3-10,20H,11-14,26H2,1-2H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283266
PNG
(4-[2-(4-amino-piperidin-1-yl)- 2'-dimethylamino-1-...)
Show SMILES CN(C)c1ncc(cn1)-c1c(nc(N2CCC(N)CC2)n(C)c1=O)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C23H25FN8O/c1-30(2)22-27-12-16(13-28-22)19-20(14-4-5-15(11-25)18(24)10-14)29-23(31(3)21(19)33)32-8-6-17(26)7-9-32/h4-5,10,12-13,17H,6-9,26H2,1-3H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283283
PNG
(4-[2-[1,4]diazepan-1-yl-1-methyl- 5-(2-methyl-2H-i...)
Show SMILES Cn1cc2cc(ccc2n1)-c1c(nc(N2CCCNCC2)n(C)c1=O)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C25H24FN7O/c1-31-15-19-12-16(6-7-21(19)30-31)22-23(17-4-5-18(14-27)20(26)13-17)29-25(32(2)24(22)34)33-10-3-8-28-9-11-33/h4-7,12-13,15,28H,3,8-11H2,1-2H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283317
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-(6- ethoxypyridin-3...)
Show SMILES CCOc1ccc(cn1)-c1c(nc(N2CCC(N)CC2)n(C)c1=O)-c1ccc([N+]#[C-])c(F)c1
Show InChI InChI=1S/C24H25FN6O2/c1-4-33-20-8-6-16(14-28-20)21-22(15-5-7-19(27-2)18(25)13-15)29-24(30(3)23(21)32)31-11-9-17(26)10-12-31/h5-8,13-14,17H,4,9-12,26H2,1,3H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283320
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-[4-(2- hydroxyethox...)
Show SMILES Cn1c(nc(-c2ccc(cc2)[N+]#[C-])c(-c2ccc(OCCO)cc2)c1=O)N1CCC(N)CC1
Show InChI InChI=1S/C25H27N5O3/c1-27-20-7-3-18(4-8-20)23-22(17-5-9-21(10-6-17)33-16-15-31)24(32)29(2)25(28-23)30-13-11-19(26)12-14-30/h3-10,19,31H,11-16,26H2,2H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283321
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-[4-(2- methoxyethox...)
Show SMILES COCCOc1ccc(cc1)-c1c(nc(N2CCC(N)CC2)n(C)c1=O)-c1ccc([N+]#[C-])c(F)c1
Show InChI InChI=1S/C26H28FN5O3/c1-29-22-9-6-18(16-21(22)27)24-23(17-4-7-20(8-5-17)35-15-14-34-3)25(33)31(2)26(30-24)32-12-10-19(28)11-13-32/h4-9,16,19H,10-15,28H2,2-3H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283331
PNG
(4-[2-(4-aminopiperidin-1-yl)-1- methyl-6-oxopyrimi...)
Show SMILES Cn1c(nc(cc1=O)-c1ccc(C#N)c(F)c1)N1CCC(N)CC1
Show InChI InChI=1S/C17H18FN5O/c1-22-16(24)9-15(11-2-3-12(10-19)14(18)8-11)21-17(22)23-6-4-13(20)5-7-23/h2-3,8-9,13H,4-7,20H2,1H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283218
PNG
(4-[2-(4-amino-piperidin-1-yl)-5- (6-methoxy-pyridi...)
Show SMILES Cc1ccc(cn1)-c1c(nc(N2CCC(N)CC2)n(C)c1=O)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C23H23FN6O/c1-14-3-4-17(13-27-14)20-21(15-5-6-16(12-25)19(24)11-15)28-23(29(2)22(20)31)30-9-7-18(26)8-10-30/h3-6,11,13,18H,7-10,26H2,1-2H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283235
PNG
(4-{2-(4-aminopiperidyl)-1-methyl- 6-oxo-5-[6-(trif...)
Show SMILES Cn1c(nc(-c2ccc(C#N)c(F)c2)c(-c2ccc(nc2)C(F)(F)F)c1=O)N1CCC(N)CC1
Show InChI InChI=1S/C23H20F4N6O/c1-32-21(34)19(15-4-5-18(30-12-15)23(25,26)27)20(13-2-3-14(11-28)17(24)10-13)31-22(32)33-8-6-16(29)7-9-33/h2-5,10,12,16H,6-9,29H2,1H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283239
PNG
(4-[2-((3R)-3-aminopyrrolidinyl)- 5-(3-fluoro-4-met...)
Show SMILES COc1ccc(cc1F)-c1c(nc(N2CC[C@@H](N)C2)n(C)c1=O)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C23H21F2N5O2/c1-29-22(31)20(13-5-6-19(32-2)18(25)9-13)21(14-3-4-15(11-26)17(24)10-14)28-23(29)30-8-7-16(27)12-30/h3-6,9-10,16H,7-8,12,27H2,1-2H3/t16-/m1/s1
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283250
PNG
(4-[2-(4-amino-piperidin-1-yl)-1- methyl-5-(1-methy...)
Show SMILES Cn1ncc2cc(ccc12)-c1c(nc(N2CCC(N)CC2)n(C)c1=O)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C25H24FN7O/c1-31-24(34)22(15-5-6-21-18(11-15)14-29-32(21)2)23(16-3-4-17(13-27)20(26)12-16)30-25(31)33-9-7-19(28)8-10-33/h3-6,11-12,14,19H,7-10,28H2,1-2H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283269
PNG
(2-fluoro-4-{5-(4-methoxy-phenyl)- 1-methyl-6-oxo-2...)
Show SMILES COc1ccc(cc1)-c1c(nc(NC[C@@H]2CCNC2)n(C)c1=O)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C24H24FN5O2/c1-30-23(31)21(16-5-7-19(32-2)8-6-16)22(17-3-4-18(12-26)20(25)11-17)29-24(30)28-14-15-9-10-27-13-15/h3-8,11,15,27H,9-10,13-14H2,1-2H3,(H,28,29)/t15-/m1/s1
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283276
PNG
(4-[2-(4-amino-piperidin-1-yl)-5- (4-dimethylamino-...)
Show SMILES CN(C)c1ccc(cc1)-c1c(nc(N2CCC(N)CC2)n(C)c1=O)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C25H27FN6O/c1-30(2)20-8-6-16(7-9-20)22-23(17-4-5-18(15-27)21(26)14-17)29-25(31(3)24(22)33)32-12-10-19(28)11-13-32/h4-9,14,19H,10-13,28H2,1-3H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283278
PNG
(4-[2-[1,4]diazepan-1-yl-5-(6- methoxy-pyridin-3-yl...)
Show SMILES COc1ccc(cn1)-c1c(nc(N2CCCNCC2)n(C)c1=O)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C23H23FN6O2/c1-29-22(31)20(17-6-7-19(32-2)27-14-17)21(15-4-5-16(13-25)18(24)12-15)28-23(29)30-10-3-8-26-9-11-30/h4-7,12,14,26H,3,8-11H2,1-2H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283282
PNG
(2-fluoro-4-[1-methyl-2- (4-methylamino-piperidin-1...)
Show SMILES CNC1CCN(CC1)c1nc(-c2ccc(C#N)c(F)c2)c(-c2ccc3nn(C)cc3c2)c(=O)n1C
Show InChI InChI=1S/C26H26FN7O/c1-29-20-8-10-34(11-9-20)26-30-24(17-4-5-18(14-28)21(27)13-17)23(25(35)33(26)3)16-6-7-22-19(12-16)15-32(2)31-22/h4-7,12-13,15,20,29H,8-11H2,1-3H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283284
PNG
(4-[2-[1,4]diazepan-1-yl-5- (6-dimethylamino-pyridi...)
Show SMILES CN(C)c1ccc(cn1)-c1c(nc(N2CCCNCC2)n(C)c1=O)-c1ccc(cc1)C#N
Show InChI InChI=1S/C24H27N7O/c1-29(2)20-10-9-19(16-27-20)21-22(18-7-5-17(15-25)6-8-18)28-24(30(3)23(21)32)31-13-4-11-26-12-14-31/h5-10,16,26H,4,11-14H2,1-3H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283290
PNG
(4-[2-(4-dimethylamino-piperidin-1- yl)-1-methyl-5-...)
Show SMILES CN(C)C1CCN(CC1)c1nc(-c2ccc(C#N)c(F)c2)c(-c2ccc3nn(C)cc3c2)c(=O)n1C
Show InChI InChI=1S/C27H28FN7O/c1-32(2)21-9-11-35(12-10-21)27-30-25(18-5-6-19(15-29)22(28)14-18)24(26(36)34(27)4)17-7-8-23-20(13-17)16-33(3)31-23/h5-8,13-14,16,21H,9-12H2,1-4H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283292
PNG
(4-[2-(4-amino-piperidin-1-yl)-5- (1H-indol-5-yl)-1...)
Show SMILES Cn1c(nc(-c2ccc([N+]#[C-])c(F)c2)c(-c2ccc3[nH]ccc3c2)c1=O)N1CCC(N)CC1
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283295
PNG
(4-[2-(4-amino-piperidin-1-yl)-1- methyl-5-(1-methy...)
Show SMILES Cn1ccc2ccc(cc12)-c1c(nc(N2CCC(N)CC2)n(C)c1=O)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C26H25FN6O/c1-31-10-7-16-3-4-17(14-22(16)31)23-24(18-5-6-19(15-28)21(27)13-18)30-26(32(2)25(23)34)33-11-8-20(29)9-12-33/h3-7,10,13-14,20H,8-9,11-12,29H2,1-2H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283310
PNG
(4-[2-(4-aminopiperidin-1-yl)-5- (1H-indazol-5-yl)-...)
Show SMILES Cn1c(nc(-c2ccc([N+]#[C-])c(F)c2)c(-c2ccc3[nH]ncc3c2)c1=O)N1CCC(N)CC1
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283322
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-[4-(2- hydroxyethyl...)
Show SMILES Cn1c(nc(-c2ccc([N+]#[C-])c(F)c2)c(-c2ccc(CCO)cc2)c1=O)N1CCC(N)CC1
Show InChI InChI=1S/C25H26FN5O2/c1-28-21-8-7-18(15-20(21)26)23-22(17-5-3-16(4-6-17)11-14-32)24(33)30(2)25(29-23)31-12-9-19(27)10-13-31/h3-8,15,19,32H,9-14,27H2,2H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283323
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-[4- (hydroxymethyl)...)
Show SMILES Cn1c(nc(-c2ccc([N+]#[C-])c(F)c2)c(-c2ccc(CO)cc2)c1=O)N1CCC(N)CC1
Show InChI InChI=1S/C24H24FN5O2/c1-27-20-8-7-17(13-19(20)25)22-21(16-5-3-15(14-31)4-6-16)23(32)29(2)24(28-22)30-11-9-18(26)10-12-30/h3-8,13,18,31H,9-12,14,26H2,2H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283328
PNG
(4-[2-(4-aminopiperidin-1-yl)-1- methyl-5-(4-methyl...)
Show SMILES Cn1c(nc(-c2ccc([N+]#[C-])c(F)c2)c(-c2ccc(cc2)S(C)(=O)=O)c1=O)N1CCC(N)CC1
Show InChI InChI=1S/C24H24FN5O3S/c1-27-20-9-6-16(14-19(20)25)22-21(15-4-7-18(8-5-15)34(3,32)33)23(31)29(2)24(28-22)30-12-10-17(26)11-13-30/h4-9,14,17H,10-13,26H2,2-3H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283134
PNG
(4-[2-(4-amino-piperidin-1-yl)-5- (6-methoxypyridin...)
Show SMILES COc1ccc(cn1)-c1c(nc(N2CCC(N)CC2)n(C)c1=O)-c1ccc(cc1)C#N
Show InChI InChI=1S/C23H24N6O2/c1-28-22(30)20(17-7-8-19(31-2)26-14-17)21(16-5-3-15(13-24)4-6-16)27-23(28)29-11-9-18(25)10-12-29/h3-8,14,18H,9-12,25H2,1-2H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283236
PNG
(4-[2-(4-aminopiperidyl)-1-methyl- 5-(2-methyl(2H-i...)
Show SMILES Cn1cc2cc(ccc2n1)-c1c(nc(N2CCC(N)CC2)n(C)c1=O)-c1ccc(cc1)C#N
Show InChI InChI=1S/C25H25N7O/c1-30-15-19-13-18(7-8-21(19)29-30)22-23(17-5-3-16(14-26)4-6-17)28-25(31(2)24(22)33)32-11-9-20(27)10-12-32/h3-8,13,15,20H,9-12,27H2,1-2H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283253
PNG
(4-[2-(4-aminopiperidyl)-5- (3,5-difluoro-4-methoxy...)
Show SMILES COc1c(F)cc(cc1F)-c1c(nc(N2CCC(N)CC2)n(C)c1=O)-c1ccc(cc1)C#N
Show InChI InChI=1S/C24H23F2N5O2/c1-30-23(32)20(16-11-18(25)22(33-2)19(26)12-16)21(15-5-3-14(13-27)4-6-15)29-24(30)31-9-7-17(28)8-10-31/h3-6,11-12,17H,7-10,28H2,1-2H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283255
PNG
(US10023543, Example 40 | {4-[2-(4-aminopiperidyl)-...)
Show SMILES CNC(=O)c1ccc(cc1F)-c1c(nc(N2CCC(N)CC2)n(C)c1=O)-c1ccc(cc1)C#N
Show InChI InChI=1S/C25H25FN6O2/c1-29-23(33)19-8-7-17(13-20(19)26)21-22(16-5-3-15(14-27)4-6-16)30-25(31(2)24(21)34)32-11-9-18(28)10-12-32/h3-8,13,18H,9-12,28H2,1-2H3,(H,29,33)
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283256
PNG
(4-[2-(4-aminopiperidyl)-6- (4-cyanophenyl)-3-methy...)
Show SMILES Cn1c(nc(-c2ccc(cc2)C#N)c(-c2ccc(C(N)=O)c(F)c2)c1=O)N1CCC(N)CC1
Show InChI InChI=1S/C24H23FN6O2/c1-30-23(33)20(16-6-7-18(22(28)32)19(25)12-16)21(15-4-2-14(13-26)3-5-15)29-24(30)31-10-8-17(27)9-11-31/h2-7,12,17H,8-11,27H2,1H3,(H2,28,32)
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283264
PNG
(2-fluoro-4-[5-(3-fluoro- 4-methoxy-phenyl)-1-methy...)
Show SMILES COc1ccc(cc1F)-c1c(nc(N2CCNCC2)n(C)c1=O)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C23H21F2N5O2/c1-29-22(31)20(14-5-6-19(32-2)18(25)11-14)21(15-3-4-16(13-26)17(24)12-15)28-23(29)30-9-7-27-8-10-30/h3-6,11-12,27H,7-10H2,1-2H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283273
PNG
(2-fluoro-4-[5-(4-methoxy-phenyl)- 1-methyl-2-(meth...)
Show SMILES COc1ccc(cc1)-c1c(nc(N(C)C[C@@H]2CCNC2)n(C)c1=O)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C25H26FN5O2/c1-30(15-16-10-11-28-14-16)25-29-23(18-4-5-19(13-27)21(26)12-18)22(24(32)31(25)2)17-6-8-20(33-3)9-7-17/h4-9,12,16,28H,10-11,14-15H2,1-3H3/t16-/m1/s1
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283285
PNG
(4-[2-(4-amino-piperidin-1-yl)-1- methyl-5-(6-morph...)
Show SMILES Cn1c(nc(-c2ccc(C#N)c(F)c2)c(-c2ccc(nc2)N2CCOCC2)c1=O)N1CCC(N)CC1
Show InChI InChI=1S/C26H28FN7O2/c1-32-25(35)23(19-4-5-22(30-16-19)33-10-12-36-13-11-33)24(17-2-3-18(15-28)21(27)14-17)31-26(32)34-8-6-20(29)7-9-34/h2-5,14,16,20H,6-13,29H2,1H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283291
PNG
(4-[2-(4-dimethylamino-piperidin-1- yl)-1-methyl-5-...)
Show SMILES CN(C)C1CCN(CC1)c1nc(-c2ccc(C#N)c(F)c2)c(-c2ccc3n(C)ncc3c2)c(=O)n1C
Show InChI InChI=1S/C27H28FN7O/c1-32(2)21-9-11-35(12-10-21)27-31-25(18-5-6-19(15-29)22(28)14-18)24(26(36)33(27)3)17-7-8-23-20(13-17)16-30-34(23)4/h5-8,13-14,16,21H,9-12H2,1-4H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283294
PNG
(4-[2-(4-amino-piperidin-1-yl)-5- (1H-indol-6-yl)-1...)
Show SMILES Cn1c(nc(-c2ccc(C#N)c(F)c2)c(-c2ccc3cc[nH]c3c2)c1=O)N1CCC(N)CC1
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283299
PNG
(4-[2-(4-dimethylamino-piperidin-1- yl)-1-methyl-5-...)
Show SMILES CN(C)C1CCN(CC1)c1nc(-c2ccc(C#N)c(F)c2)c(-c2ccc3cn(C)nc3c2)c(=O)n1C
Show InChI InChI=1S/C27H28FN7O/c1-32(2)21-9-11-35(12-10-21)27-30-25(18-6-7-19(15-29)22(28)13-18)24(26(36)34(27)4)17-5-8-20-16-33(3)31-23(20)14-17/h5-8,13-14,16,21H,9-12H2,1-4H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283309
PNG
(2-fluoro-4-[1-methyl-2- [4-(methylamino)piperidin-...)
Show SMILES CNC1CCN(CC1)c1nc(-c2ccc(C#N)c(F)c2)c(-c2ccc3n(C)ncc3c2)c(=O)n1C
Show InChI InChI=1S/C26H26FN7O/c1-29-20-8-10-34(11-9-20)26-31-24(17-4-5-18(14-28)21(27)13-17)23(25(35)32(26)2)16-6-7-22-19(12-16)15-30-33(22)3/h4-7,12-13,15,20,29H,8-11H2,1-3H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283326
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-(3,5- difluoropheny...)
Show SMILES Cn1c(nc(-c2ccc([N+]#[C-])c(F)c2)c(-c2cc(F)cc(F)c2)c1=O)N1CCC(N)CC1
Show InChI InChI=1S/C23H20F3N5O/c1-28-19-4-3-13(11-18(19)26)21-20(14-9-15(24)12-16(25)10-14)22(32)30(2)23(29-21)31-7-5-17(27)6-8-31/h3-4,9-12,17H,5-8,27H2,2H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283327
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-(3,4- difluoropheny...)
Show SMILES Cn1c(nc(-c2ccc([N+]#[C-])c(F)c2)c(-c2ccc(F)c(F)c2)c1=O)N1CCC(N)CC1
Show InChI InChI=1S/C23H20F3N5O/c1-28-19-6-4-14(12-18(19)26)21-20(13-3-5-16(24)17(25)11-13)22(32)30(2)23(29-21)31-9-7-15(27)8-10-31/h3-6,11-12,15H,7-10,27H2,2H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283329
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-(4- chlorophenyl)-1...)
Show SMILES Cn1c(nc(-c2ccc([N+]#[C-])c(F)c2)c(-c2ccc(Cl)cc2)c1=O)N1CCC(N)CC1
Show InChI InChI=1S/C23H21ClFN5O/c1-27-19-8-5-15(13-18(19)25)21-20(14-3-6-16(24)7-4-14)22(31)29(2)23(28-21)30-11-9-17(26)10-12-30/h3-8,13,17H,9-12,26H2,2H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283330
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-[4- (methoxymethyl)...)
Show SMILES COCc1ccc(cc1)-c1c(nc(N2CCC(N)CC2)n(C)c1=O)-c1ccc([N+]#[C-])c(F)c1
Show InChI InChI=1S/C25H26FN5O2/c1-28-21-9-8-18(14-20(21)26)23-22(17-6-4-16(5-7-17)15-33-3)24(32)30(2)25(29-23)31-12-10-19(27)11-13-31/h4-9,14,19H,10-13,15,27H2,2-3H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283347
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-(4-methoxyphenyl)-6...)
Show SMILES COc1ccc(cc1)-c1c(nc([nH]c1=O)N1CCC(N)CC1)-c1ccc([N+]#[C-])c(F)c1
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283221
PNG
(2-fluoro-4-[5-(4-methoxy-phenyl)- 1-methyl-2-(4-me...)
Show SMILES CNC1CCN(CC1)c1nc(-c2ccc(C#N)c(F)c2)c(-c2ccc(OC)cc2)c(=O)n1C
Show InChI InChI=1S/C25H26FN5O2/c1-28-19-10-12-31(13-11-19)25-29-23(17-4-5-18(15-27)21(26)14-17)22(24(32)30(25)2)16-6-8-20(33-3)9-7-16/h4-9,14,19,28H,10-13H2,1-3H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283222
PNG
(2-fluoro-4-[5-(3-fluoro-4-methoxy- phenyl)-1-methy...)
Show SMILES CNC1CCN(CC1)c1nc(-c2ccc(C#N)c(F)c2)c(-c2ccc(OC)c(F)c2)c(=O)n1C
Show InChI InChI=1S/C25H25F2N5O2/c1-29-18-8-10-32(11-9-18)25-30-23(16-4-5-17(14-28)19(26)13-16)22(24(33)31(25)2)15-6-7-21(34-3)20(27)12-15/h4-7,12-13,18,29H,8-11H2,1-3H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283228
PNG
(4-[2-(4-amino-piperidin-1-yl)-5- benzofuran-5-yl-1...)
Show SMILES Cn1c(nc(-c2ccc(C#N)c(F)c2)c(-c2ccc3occc3c2)c1=O)N1CCC(N)CC1
Show InChI InChI=1S/C25H22FN5O2/c1-30-24(32)22(16-4-5-21-15(12-16)8-11-33-21)23(17-2-3-18(14-27)20(26)13-17)29-25(30)31-9-6-19(28)7-10-31/h2-5,8,11-13,19H,6-7,9-10,28H2,1H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283234
PNG
(4-[2-(2,8-diaza-spiro[4.5]dec-8-yl)- 5-(3-fluoro-4...)
Show SMILES COc1ccc(cc1F)-c1c(nc(N2CCC3(CCNC3)CC2)n(C)c1=O)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C27H27F2N5O2/c1-33-25(35)23(17-5-6-22(36-2)21(29)13-17)24(18-3-4-19(15-30)20(28)14-18)32-26(33)34-11-8-27(9-12-34)7-10-31-16-27/h3-6,13-14,31H,7-12,16H2,1-2H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283241
PNG
(4-[2-((3S)-3-amino-piperidin-1- yl)-5-(3-fluoro-4-...)
Show SMILES COc1ccc(cc1F)-c1c(nc(N2CCC[C@H](N)C2)n(C)c1=O)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C24H23F2N5O2/c1-30-23(32)21(14-7-8-20(33-2)19(26)10-14)22(15-5-6-16(12-27)18(25)11-15)29-24(30)31-9-3-4-17(28)13-31/h5-8,10-11,17H,3-4,9,13,28H2,1-2H3/t17-/m0/s1
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283244
PNG
(4-[2-((3S)-3-amino-piperidin-1- yl)-5-(4-methoxy-p...)
Show SMILES COc1ccc(cc1)-c1c(nc(N2CCC[C@H](N)C2)n(C)c1=O)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C24H24FN5O2/c1-29-23(31)21(15-7-9-19(32-2)10-8-15)22(16-5-6-17(13-26)20(25)12-16)28-24(29)30-11-3-4-18(27)14-30/h5-10,12,18H,3-4,11,14,27H2,1-2H3/t18-/m0/s1
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283267
PNG
(5-[2-(4-amino-piperidin-1-yl)-4- (4-cyano-3-fluoro...)
Show SMILES CNC(=O)c1ccc(cn1)-c1c(nc(N2CCC(N)CC2)n(C)c1=O)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C24H24FN7O2/c1-28-22(33)19-6-5-16(13-29-19)20-21(14-3-4-15(12-26)18(25)11-14)30-24(31(2)23(20)34)32-9-7-17(27)8-10-32/h3-6,11,13,17H,7-10,27H2,1-2H3,(H,28,33)
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283270
PNG
(2-fluoro-4-[5-(4-methoxy-phenyl)- 1-methyl-6-oxo-2...)
Show SMILES COc1ccc(cc1)-c1c(nc(NC2CCNCC2)n(C)c1=O)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C24H24FN5O2/c1-30-23(31)21(15-5-7-19(32-2)8-6-15)22(16-3-4-17(14-26)20(25)13-16)29-24(30)28-18-9-11-27-12-10-18/h3-8,13,18,27H,9-12H2,1-2H3,(H,28,29)
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283271
PNG
(2-fluoro-4-[5-(4-methoxy-phenyl)- 1-methyl-2-(meth...)
Show SMILES COc1ccc(cc1)-c1c(nc(N(C)C[C@H]2CCNC2)n(C)c1=O)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C25H26FN5O2/c1-30(15-16-10-11-28-14-16)25-29-23(18-4-5-19(13-27)21(26)12-18)22(24(32)31(25)2)17-6-8-20(33-3)9-7-17/h4-9,12,16,28H,10-11,14-15H2,1-3H3/t16-/m0/s1
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283272
PNG
(2-fluoro-4-[5-(4-methoxy-phenyl)- 1-methyl-2-(meth...)
Show SMILES COc1ccc(cc1)-c1c(nc(N(C)C2CCNCC2)n(C)c1=O)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C25H26FN5O2/c1-30(19-10-12-28-13-11-19)25-29-23(17-4-5-18(15-27)21(26)14-17)22(24(32)31(25)2)16-6-8-20(33-3)9-7-16/h4-9,14,19,28H,10-13H2,1-3H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283277
PNG
(4-[2-(4-amino-piperidin-1-yl)-1- methyl-6-oxo-5-(6...)
Show SMILES Cn1c(nc(-c2ccc(C#N)c(F)c2)c(-c2ccc(nc2)N2CCCC2)c1=O)N1CCC(N)CC1
Show InChI InChI=1S/C26H28FN7O/c1-32-25(35)23(19-6-7-22(30-16-19)33-10-2-3-11-33)24(17-4-5-18(15-28)21(27)14-17)31-26(32)34-12-8-20(29)9-13-34/h4-7,14,16,20H,2-3,8-13,29H2,1H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283216
PNG
(4-[2-(4-amino-piperidin-1-yl)-5- (3-fluoro-4-metho...)
Show SMILES COc1ccc(cc1F)-c1c(nc(N2CCC(N)CC2)n(C)c1=O)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C24H23F2N5O2/c1-30-23(32)21(14-5-6-20(33-2)19(26)11-14)22(15-3-4-16(13-27)18(25)12-15)29-24(30)31-9-7-17(28)8-10-31/h3-6,11-12,17H,7-10,28H2,1-2H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283312
PNG
(4-[2-(4-aminopiperidin-1-yl)-1- methyl-5-[4-(methy...)
Show SMILES CNc1ccc(cc1)-c1c(nc(N2CCC(N)CC2)n(C)c1=O)-c1ccc([N+]#[C-])c(F)c1
Show InChI InChI=1S/C24H25FN6O/c1-27-18-7-4-15(5-8-18)21-22(16-6-9-20(28-2)19(25)14-16)29-24(30(3)23(21)32)31-12-10-17(26)11-13-31/h4-9,14,17,27H,10-13,26H2,1,3H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283314
PNG
(4-[2-[4-(dimethylamino)piperidin- 1-yl]-5-(6-metho...)
Show SMILES COc1ccc(cn1)-c1c(nc(N2CCC(CC2)N(C)C)n(C)c1=O)-c1ccc([N+]#[C-])c(F)c1
Show InChI InChI=1S/C25H27FN6O2/c1-27-20-8-6-16(14-19(20)26)23-22(17-7-9-21(34-5)28-15-17)24(33)31(4)25(29-23)32-12-10-18(11-13-32)30(2)3/h6-9,14-15,18H,10-13H2,2-5H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283319
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-[4-(2- hydroxyethox...)
Show SMILES Cn1c(nc(-c2ccc([N+]#[C-])c(F)c2)c(-c2ccc(OCCO)cc2)c1=O)N1CCC(N)CC1
Show InChI InChI=1S/C25H26FN5O3/c1-28-21-8-5-17(15-20(21)26)23-22(16-3-6-19(7-4-16)34-14-13-32)24(33)30(2)25(29-23)31-11-9-18(27)10-12-31/h3-8,15,18,32H,9-14,27H2,2H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283341
PNG
(2-(4-amino-piperidin-1-yl)-3- methyl-5-(1-methyl-1...)
Show SMILES Cn1ccc2cc(ccc12)-c1c(nc(N2CCC(N)CC2)n(C)c1=O)-c1ccncc1
Show InChI InChI=1S/C24H26N6O/c1-28-12-7-17-15-18(3-4-20(17)28)21-22(16-5-10-26-11-6-16)27-24(29(2)23(21)31)30-13-8-19(25)9-14-30/h3-7,10-12,15,19H,8-9,13-14,25H2,1-2H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283332
PNG
(4-[2-(4-amino-piperidin-1-yl)-1- cyclopropylmethyl...)
Show SMILES NC1CCN(CC1)c1nc(cc(=O)n1CC1CC1)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C20H22FN5O/c21-17-9-14(3-4-15(17)11-22)18-10-19(27)26(12-13-1-2-13)20(24-18)25-7-5-16(23)6-8-25/h3-4,9-10,13,16H,1-2,5-8,12,23H2
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283334
PNG
(2-(4-amino-piperidin-1-yl)-6-(4- chloro-3-fluoro-p...)
Show SMILES COc1ccc(cc1)-c1c(nc(N2CCC(N)CC2)n(C)c1=O)-c1ccc(Cl)c(F)c1
Show InChI InChI=1S/C23H24ClFN4O2/c1-28-22(30)20(14-3-6-17(31-2)7-4-14)21(15-5-8-18(24)19(25)13-15)27-23(28)29-11-9-16(26)10-12-29/h3-8,13,16H,9-12,26H2,1-2H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283227
PNG
(4-[2-(4-amino-piperidin-1-yl)-1- (3-hydroxy-propyl...)
Show SMILES NC1CCN(CC1)c1nc(cc(=O)n1CCCO)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C19H22FN5O2/c20-16-10-13(2-3-14(16)12-21)17-11-18(27)25(6-1-9-26)19(23-17)24-7-4-15(22)5-8-24/h2-3,10-11,15,26H,1,4-9,22H2
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283254
PNG
(4-[2-(4-aminopiperidyl)-6-(4- cyano-3-fluorophenyl...)
Show SMILES Cn1c(nc(-c2ccc(C#N)c(F)c2)c(-c2ccc(cc2)C(O)=O)c1=O)N1CCC(N)CC1
Show InChI InChI=1S/C24H22FN5O3/c1-29-22(31)20(14-2-4-15(5-3-14)23(32)33)21(16-6-7-17(13-26)19(25)12-16)28-24(29)30-10-8-18(27)9-11-30/h2-7,12,18H,8-11,27H2,1H3,(H,32,33)
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283223
PNG
(4-[2-(4-amino-piperidin-1-yl)-1- ethyl-6-oxo-1,6-d...)
Show SMILES CCn1c(nc(cc1=O)-c1ccc(C#N)c(F)c1)N1CCC(N)CC1
Show InChI InChI=1S/C18H20FN5O/c1-2-24-17(25)10-16(12-3-4-13(11-20)15(19)9-12)22-18(24)23-7-5-14(21)6-8-23/h3-4,9-10,14H,2,5-8,21H2,1H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283338
PNG
(2-(4-amino-piperidin-1-yl)-6-(4- fluoro-phenyl)-3-...)
Show SMILES Cn1ccc2cc(ccc12)-c1c(nc(N2CCC(N)CC2)n(C)c1=O)-c1ccc(F)cc1
Show InChI InChI=1S/C25H26FN5O/c1-29-12-9-17-15-18(5-8-21(17)29)22-23(16-3-6-19(26)7-4-16)28-25(30(2)24(22)32)31-13-10-20(27)11-14-31/h3-9,12,15,20H,10-11,13-14,27H2,1-2H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283231
PNG
(2-(4-amino-piperidin-1-yl)-4-(4- cyano-3-fluoro-ph...)
Show SMILES Cn1c(nc(-c2ccc(C#N)c(F)c2)c(C#N)c1=O)N1CCC(N)CC1
Show InChI InChI=1S/C18H17FN6O/c1-24-17(26)14(10-21)16(11-2-3-12(9-20)15(19)8-11)23-18(24)25-6-4-13(22)5-7-25/h2-3,8,13H,4-7,22H2,1H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283259
PNG
(3-[2-(4-amino-piperidin-1-yl)-4- (4-cyano-3-fluoro...)
Show SMILES Cn1c(nc(-c2ccc(C#N)c(F)c2)c(-c2cccc(c2)C(O)=O)c1=O)N1CCC(N)CC1
Show InChI InChI=1S/C24H22FN5O3/c1-29-22(31)20(14-3-2-4-16(11-14)23(32)33)21(15-5-6-17(13-26)19(25)12-15)28-24(29)30-9-7-18(27)8-10-30/h2-6,11-12,18H,7-10,27H2,1H3,(H,32,33)
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283345
PNG
(2-(4-amino-piperidin-1-yl)-5-(3- fluoro-4-methoxy-...)
Show SMILES COc1ccc(cc1F)-c1c(nc(N2CCC(N)CC2)n(C)c1=O)C#N
Show InChI InChI=1S/C18H20FN5O2/c1-23-17(25)16(11-3-4-15(26-2)13(19)9-11)14(10-20)22-18(23)24-7-5-12(21)6-8-24/h3-4,9,12H,5-8,21H2,1-2H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283340
PNG
(2-(4-amino-piperidin-1-yl)-5-(3- fluoro-4-methoxy-...)
Show SMILES COc1ccc(cc1F)-c1c(nc(N2CCC(N)CC2)n(C)c1=O)-c1ccncc1
Show InChI InChI=1S/C22H24FN5O2/c1-27-21(29)19(15-3-4-18(30-2)17(23)13-15)20(14-5-9-25-10-6-14)26-22(27)28-11-7-16(24)8-12-28/h3-6,9-10,13,16H,7-8,11-12,24H2,1-2H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283342
PNG
(2-(4-amino-piperidin-1-yl)-6-(4- methoxy-phenyl)-3...)
Show SMILES COc1ccc(cc1)-c1nc(N2CCC(N)CC2)n(C)c(=O)c1-c1ccc2n(C)ccc2c1
Show InChI InChI=1S/C26H29N5O2/c1-29-13-10-18-16-19(6-9-22(18)29)23-24(17-4-7-21(33-3)8-5-17)28-26(30(2)25(23)32)31-14-11-20(27)12-15-31/h4-10,13,16,20H,11-12,14-15,27H2,1-3H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283336
PNG
(2-(4-amino-piperidin-1-yl)-6-(4- hydroxy-phenyl)-3...)
Show SMILES Cn1ccc2cc(ccc12)-c1c(nc(N2CCC(N)CC2)n(C)c1=O)-c1ccc(O)cc1
Show InChI InChI=1S/C25H27N5O2/c1-28-12-9-17-15-18(5-8-21(17)28)22-23(16-3-6-20(31)7-4-16)27-25(29(2)24(22)32)30-13-10-19(26)11-14-30/h3-9,12,15,19,31H,10-11,13-14,26H2,1-2H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283339
PNG
(2-(4-amino-piperidin-1-yl)-3- methyl-5-(1-methyl-1...)
Show SMILES Cn1ccc2cc(ccc12)-c1c(nc(N2CCC(N)CC2)n(C)c1=O)-c1ccccc1
Show InChI InChI=1S/C25H27N5O/c1-28-13-10-18-16-19(8-9-21(18)28)22-23(17-6-4-3-5-7-17)27-25(29(2)24(22)31)30-14-11-20(26)12-15-30/h3-10,13,16,20H,11-12,14-15,26H2,1-2H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283344
PNG
(2-[2-(4-aminopiperidin-1-yl)-5-(3- fluoro-4-methox...)
Show SMILES COc1ccc(cc1F)-c1c(nc(N2CCC(N)CC2)n(C)c1=O)-c1ccccc1C#N
Show InChI InChI=1S/C24H24FN5O2/c1-29-23(31)21(15-7-8-20(32-2)19(25)13-15)22(18-6-4-3-5-16(18)14-26)28-24(29)30-11-9-17(27)10-12-30/h3-8,13,17H,9-12,27H2,1-2H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM283343
PNG
(3-[2-(4-aminopiperidin-1-yl)-5-(3- fluoro-4-methox...)
Show SMILES COc1ccc(cc1F)-c1c(nc(N2CCC(N)CC2)n(C)c1=O)-c1cccc(c1)C#N
Show InChI InChI=1S/C24H24FN5O2/c1-29-23(31)21(16-6-7-20(32-2)19(25)13-16)22(17-5-3-4-15(12-17)14-26)28-24(29)30-10-8-18(27)9-11-30/h3-7,12-13,18H,8-11,27H2,1-2H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...


US Patent US10023543 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%