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Patent code US10023576

Compile Data Set for Download or QSAR
Found 117 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284822
PNG
(1-((cis)-4-(5-(4-amino-5-(1-(tetrahydro-2H-pyran-4...)
Show SMILES C[C@H]1CN(C[C@@H](C)N1c1cncc(c1)-c1cc(-c2cnnn2C2CCOCC2)c2c(N)ncnn12)C(C)=O
Show InChI InChI=1S/C26H32N10O2/c1-16-13-33(18(3)37)14-17(2)34(16)21-8-19(10-28-11-21)23-9-22(25-26(27)29-15-31-36(23)25)24-12-30-32-35(24)20-4-6-38-7-5-20/h8-12,15-17,20H,4-7,13-14H2,1-3H3,(H2,27,29,31)/t16-,17+
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Bristol-Myers Squibb Company

US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284900
PNG
((S)-4-acetyl-1-(5-(4-amino-5- chloropyrrolo[2,1-f]...)
Show SMILES C[C@H]1CN(C(C)=O)C(C)(C)C(=O)N1c1cncc(c1)-c1cc(Cl)c2c(N)ncnn12
Show InChI InChI=1S/C20H22ClN7O2/c1-11-9-26(12(2)29)20(3,4)19(30)27(11)14-5-13(7-23-8-14)16-6-15(21)17-18(22)24-10-25-28(16)17/h5-8,10-11H,9H2,1-4H3,(H2,22,24,25)/t11-/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284821
PNG
(1-((cis)-4-(5-(4-amino-5-(1-(tetrahydro-2H-pyran-4...)
Show SMILES C[C@H]1CN(C[C@@H](C)N1c1cncc(c1)-c1cc(-c2ccnn2C2CCOCC2)c2c(N)ncnn12)C(C)=O
Show InChI InChI=1S/C27H33N9O2/c1-17-14-33(19(3)37)15-18(2)34(17)22-10-20(12-29-13-22)25-11-23(26-27(28)30-16-32-36(25)26)24-4-7-31-35(24)21-5-8-38-9-6-21/h4,7,10-13,16-18,21H,5-6,8-9,14-15H2,1-3H3,(H2,28,30,32)/t17-,18+
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Bristol-Myers Squibb Company

US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284825
PNG
(1-(4-(5-(4-amino-5-(1-(tetrahydro-2H-pyran-4-yl)-1...)
Show SMILES CC1C(C)N(C(C)C(C)N1C(C)=O)c1cncc(c1)-c1cc(-c2cnnn2C2CCOCC2)c2c(N)ncnn12
Show InChI InChI=1S/C28H36N10O2/c1-16-18(3)36(19(4)17(2)35(16)20(5)39)23-10-21(12-30-13-23)25-11-24(27-28(29)31-15-33-38(25)27)26-14-32-34-37(26)22-6-8-40-9-7-22/h10-19,22H,6-9H2,1-5H3,(H2,29,31,33)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284824
PNG
(1-(4-(5-(4-amino-5-(1-(tetrahydro-2H-pyran-4-yl)-1...)
Show SMILES CC1C(C)N(C(C)C(C)N1C(C)=O)c1cncc(c1)-c1cc(-c2ccnn2C2CCOCC2)c2c(N)ncnn12
Show InChI InChI=1S/C29H37N9O2/c1-17-19(3)36(20(4)18(2)35(17)21(5)39)24-12-22(14-31-15-24)27-13-25(28-29(30)32-16-34-38(27)28)26-6-9-33-37(26)23-7-10-40-11-8-23/h6,9,12-20,23H,7-8,10-11H2,1-5H3,(H2,30,32,34)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284893
PNG
(4-acetyl-1-(5-(4-amino-5-(1- (tetrahydro-2H-pyran-...)
Show SMILES CC(=O)N1CCN(C(=O)C1(C)C)c1cncc(c1)-c1cc(-c2ccnn2C2CCOCC2)c2c(N)ncnn12
Show InChI InChI=1S/C27H31N9O3/c1-17(37)34-9-8-33(26(38)27(34,2)3)20-12-18(14-29-15-20)23-13-21(24-25(28)30-16-32-36(23)24)22-4-7-31-35(22)19-5-10-39-11-6-19/h4,7,12-16,19H,5-6,8-11H2,1-3H3,(H2,28,30,32)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284902
PNG
((S)-4-acetyl-1-(4-(4-amino-5- (trifluoromethyl)pyr...)
Show SMILES C[C@H]1CN(C(C)=O)C(C)(C)C(=O)N1c1cc(ccn1)-c1cc(c2c(N)ncnn12)C(F)(F)F
Show InChI InChI=1S/C21H22F3N7O2/c1-11-9-29(12(2)32)20(3,4)19(33)30(11)16-7-13(5-6-26-16)15-8-14(21(22,23)24)17-18(25)27-10-28-31(15)17/h5-8,10-11H,9H2,1-4H3,(H2,25,27,28)/t11-/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284899
PNG
((R)-1-(4-(4-amino-5-(1-(1,1,1- trifluoropropan-2-y...)
Show SMILES C[C@@H](n1nccc1-c1cc(-c2ccnc(c2)N2CCN(C(=O)C3CC3)C(C)(C)C2=O)n2ncnc(N)c12)C(F)(F)F
Show InChI InChI=1S/C27H28F3N9O2/c1-15(27(28,29)30)38-19(7-9-34-38)18-13-20(39-22(18)23(31)33-14-35-39)17-6-8-32-21(12-17)36-10-11-37(24(40)16-4-5-16)26(2,3)25(36)41/h6-9,12-16H,4-5,10-11H2,1-3H3,(H2,31,33,35)/t15-/m1/s1
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US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284856
PNG
(7-(1-(cyclopropylmethyl)-1H-benzo[d]imidazol-6-yl)...)
Show SMILES Nc1ncnn2c(cc(-c3ccnn3C3CCOCC3)c12)-c1ccc2ncn(CC3CC3)c2c1
Show InChI InChI=1S/C25H26N8O/c26-25-24-19(21-5-8-29-32(21)18-6-9-34-10-7-18)12-22(33(24)30-14-27-25)17-3-4-20-23(11-17)31(15-28-20)13-16-1-2-16/h3-5,8,11-12,14-16,18H,1-2,6-7,9-10,13H2,(H2,26,27,30)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284910
PNG
((S)-4-acetyl-1-(5-(4-amino-5-(1- methyl-1H-pyrazol...)
Show SMILES C[C@H]1CN(C(C)=O)C(C)(C)C(=O)N1c1cncc(c1)-c1cc(-c2cnn(C)c2)c2c(N)ncnn12
Show InChI InChI=1S/C24H27N9O2/c1-14-11-31(15(2)34)24(3,4)23(35)32(14)18-6-16(8-26-10-18)20-7-19(17-9-28-30(5)12-17)21-22(25)27-13-29-33(20)21/h6-10,12-14H,11H2,1-5H3,(H2,25,27,29)/t14-/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284842
PNG
(5-(1-cyclohexyl-1H-1,2,3-triazol-5-yl)-7-(1-(tetra...)
Show SMILES Nc1ncnn2c(cc(-c3cnnn3C3CCCCC3)c12)-c1ccc2ncn(C3CCOCC3)c2c1
Show InChI InChI=1S/C26H29N9O/c27-26-25-20(24-14-30-32-34(24)19-4-2-1-3-5-19)13-22(35(25)31-15-28-26)17-6-7-21-23(12-17)33(16-29-21)18-8-10-36-11-9-18/h6-7,12-16,18-19H,1-5,8-11H2,(H2,27,28,31)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284823
PNG
(1-((cis)-4-(5-(4-amino-5-(1-isopropyl-1H-1,2,3-tri...)
Show SMILES CC(C)n1nncc1-c1cc(-c2cncc(c2)N2[C@@H](C)CN(C[C@H]2C)C(C)=O)n2ncnc(N)c12
Show InChI InChI=1S/C24H30N10O/c1-14(2)33-22(10-28-30-33)20-7-21(34-23(20)24(25)27-13-29-34)18-6-19(9-26-8-18)32-15(3)11-31(17(5)35)12-16(32)4/h6-10,13-16H,11-12H2,1-5H3,(H2,25,27,29)/t15-,16+
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US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284831
PNG
(1-(4-(6-(4-amino-5-(1-(tetrahydro-2H-pyran-4-yl)-1...)
Show SMILES CC(=O)N1CCC(CC1)n1ncc2ccc(cc12)-c1cc(-c2cnnn2C2CCOCC2)c2c(N)ncnn12
Show InChI InChI=1S/C27H30N10O2/c1-17(38)34-8-4-20(5-9-34)35-23-12-18(2-3-19(23)14-31-35)24-13-22(26-27(28)29-16-32-37(24)26)25-15-30-33-36(25)21-6-10-39-11-7-21/h2-3,12-16,20-21H,4-11H2,1H3,(H2,28,29,32)
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US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284826
PNG
(7-(1-(Tetrahydro-2H-pyran-4-yl)-1H-indazol-6-yl)-5...)
Show SMILES Nc1ncnn2c(cc(-c3ccnn3C3CCOCC3)c12)-c1ccc2cnn(C3CCOCC3)c2c1
Show InChI InChI=1S/C26H28N8O2/c27-26-25-21(22-3-8-29-32(22)19-4-9-35-10-5-19)14-24(34(25)31-16-28-26)17-1-2-18-15-30-33(23(18)13-17)20-6-11-36-12-7-20/h1-3,8,13-16,19-20H,4-7,9-12H2,(H2,27,28,31)
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US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284872
PNG
(7-(2-(4-(oxetan-3-yl)piperazin-1- yl)pyridin-4-yl)...)
Show SMILES Nc1ncnn2c(cc(-c3ccnn3C3CCOCC3)c12)-c1ccnc(c1)N1CCN(CC1)C1COC1
Show InChI InChI=1S/C26H31N9O2/c27-26-25-21(22-2-6-30-34(22)19-3-11-36-12-4-19)14-23(35(25)31-17-29-26)18-1-5-28-24(13-18)33-9-7-32(8-10-33)20-15-37-16-20/h1-2,5-6,13-14,17,19-20H,3-4,7-12,15-16H2,(H2,27,29,31)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284912
PNG
(((S)-4-acetyl-1-(5-(4-amino-5-(1- (2,2,2-trifluoro...)
Show SMILES C[C@H]1CN(C(C)=O)C(C)(C)C(=O)N1c1cncc(c1)-c1cc(-c2ccnn2CC(F)(F)F)c2c(N)ncnn12
Show InChI InChI=1S/C25H26F3N9O2/c1-14-11-34(15(2)38)24(3,4)23(39)36(14)17-7-16(9-30-10-17)20-8-18(21-22(29)31-13-33-37(20)21)19-5-6-32-35(19)12-25(26,27)28/h5-10,13-14H,11-12H2,1-4H3,(H2,29,31,33)/t14-/m0/s1
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US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284906
PNG
((S)-4-acetyl-1-(4-(4-amino-5- chloropyrrolo[2,1-f]...)
Show SMILES C[C@H]1CN(C(C)=O)C(C)(C)C(=O)N1c1cc(ccn1)-c1cc(Cl)c2c(N)ncnn12
Show InChI InChI=1S/C20H22ClN7O2/c1-11-9-26(12(2)29)20(3,4)19(30)27(11)16-7-13(5-6-23-16)15-8-14(21)17-18(22)24-10-25-28(15)17/h5-8,10-11H,9H2,1-4H3,(H2,22,24,25)/t11-/m0/s1
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US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284901
PNG
((S)-4-acetyl-1-(5-(4-amino-5- (trifluoromethyl)pyr...)
Show SMILES C[C@H]1CN(C(C)=O)C(C)(C)C(=O)N1c1cncc(c1)-c1cc(c2c(N)ncnn12)C(F)(F)F
Show InChI InChI=1S/C21H22F3N7O2/c1-11-9-29(12(2)32)20(3,4)19(33)30(11)14-5-13(7-26-8-14)16-6-15(21(22,23)24)17-18(25)27-10-28-31(16)17/h5-8,10-11H,9H2,1-4H3,(H2,25,27,28)/t11-/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284917
PNG
((S)-7-(6-(4-acetyl-3,3,6-trimethyl-2- oxopiperazin...)
Show SMILES C[C@H]1CN(C(C)=O)C(C)(C)C(=O)N1c1cccc(n1)-c1cc(C#N)c2c(N)ncnn12
Show InChI InChI=1S/C21H22N8O2/c1-12-10-27(13(2)30)21(3,4)20(31)28(12)17-7-5-6-15(26-17)16-8-14(9-22)18-19(23)24-11-25-29(16)18/h5-8,11-12H,10H2,1-4H3,(H2,23,24,25)/t12-/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284839
PNG
(7-(3-methyl-1-(tetrahydro-2H-pyran-4-yl)-1H-indazo...)
Show SMILES Cc1nn(C2CCOCC2)c2cc(ccc12)-c1cc(-c2cnnn2C2CCOCC2)c2c(N)ncnn12
Show InChI InChI=1S/C26H29N9O2/c1-16-20-3-2-17(12-23(20)33(31-16)18-4-8-36-9-5-18)22-13-21(25-26(27)28-15-30-35(22)25)24-14-29-32-34(24)19-6-10-37-11-7-19/h2-3,12-15,18-19H,4-11H2,1H3,(H2,27,28,30)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284837
PNG
(7-(1-(2,6-dimethyltetrahydro-2H-pyran-4-yl)-1H-ind...)
Show SMILES CC1COCC(C)C1n1ncc2ccc(cc12)-c1cc(-c2ccnn2C2CCOCC2)c2c(N)ncnn12
Show InChI InChI=1S/C28H32N8O2/c1-17-14-38-15-18(2)26(17)35-24-11-19(3-4-20(24)13-32-35)25-12-22(27-28(29)30-16-33-36(25)27)23-5-8-31-34(23)21-6-9-37-10-7-21/h3-5,8,11-13,16-18,21,26H,6-7,9-10,14-15H2,1-2H3,(H2,29,30,33)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284835
PNG
(5-(1-isopropyl-1H-1,2,3-triazol-5-yl)-7-(1-(tetrah...)
Show SMILES CC(C)n1nncc1-c1cc(-c2ccc3cnn(C4CCOCC4)c3c2)n2ncnc(N)c12
Show InChI InChI=1S/C23H25N9O/c1-14(2)30-21(12-26-29-30)18-10-20(32-22(18)23(24)25-13-28-32)15-3-4-16-11-27-31(19(16)9-15)17-5-7-33-8-6-17/h3-4,9-14,17H,5-8H2,1-2H3,(H2,24,25,28)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284818
PNG
(4-(5-(4-amino-5-(1-isopropyl-1H-1,2,3-triazol-5-yl...)
Show SMILES CC(C)n1nncc1-c1cc(-c2cncc(c2)N2CCS(=O)(=O)CC2)n2ncnc(N)c12
Show InChI InChI=1S/C20H23N9O2S/c1-13(2)28-18(11-24-26-28)16-8-17(29-19(16)20(21)23-12-25-29)14-7-15(10-22-9-14)27-3-5-32(30,31)6-4-27/h7-13H,3-6H2,1-2H3,(H2,21,23,25)
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Bristol-Myers Squibb Company

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Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284846
PNG
(4-(6-(4-amino-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-1...)
Show SMILES Nc1ncnn2c(cc(-c3cnnn3C3CCOCC3)c12)-c1cc(F)c2cnn(C3CCS(=O)(=O)CC3)c2c1
Show InChI InChI=1S/C25H26FN9O3S/c26-20-9-15(10-22-19(20)12-30-33(22)17-3-7-39(36,37)8-4-17)21-11-18(24-25(27)28-14-31-35(21)24)23-13-29-32-34(23)16-1-5-38-6-2-16/h9-14,16-17H,1-8H2,(H2,27,28,31)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284849
PNG
(4-(6-(4-amino-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-p...)
Show SMILES Nc1ncnn2c(cc(-c3ccnn3C3CCOCC3)c12)-c1ccc2ncn(C3CCS(=O)(=O)CC3)c2c1
Show InChI InChI=1S/C26H28N8O3S/c27-26-25-20(22-3-8-30-33(22)19-4-9-37-10-5-19)14-23(34(25)31-15-28-26)17-1-2-21-24(13-17)32(16-29-21)18-6-11-38(35,36)12-7-18/h1-3,8,13-16,18-19H,4-7,9-12H2,(H2,27,28,31)
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US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284840
PNG
(7-(1-(tetrahydro-2H-pyran-4-yl)-1H-benzo[d]imidazo...)
Show SMILES Nc1ncnn2c(cc(-c3ccnn3C3CCOCC3)c12)-c1ccc2ncn(C3CCOCC3)c2c1
Show InChI InChI=1S/C26H28N8O2/c27-26-25-20(22-3-8-30-33(22)19-6-11-36-12-7-19)14-23(34(25)31-15-28-26)17-1-2-21-24(13-17)32(16-29-21)18-4-9-35-10-5-18/h1-3,8,13-16,18-19H,4-7,9-12H2,(H2,27,28,31)
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US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284830
PNG
(1-(4-(6-(4-amino-5-(1-(tetrahydro-2H-pyran-4-yl)-1...)
Show SMILES CC(=C)N1CCC(CC1)n1ncc2ccc(cc12)-c1cc(-c2ccnn2C2CCOCC2)c2c(N)ncnn12
Show InChI InChI=1S/C29H33N9O/c1-19(2)35-11-6-22(7-12-35)37-26-15-20(3-4-21(26)17-33-37)27-16-24(28-29(30)31-18-34-38(27)28)25-5-10-32-36(25)23-8-13-39-14-9-23/h3-5,10,15-18,22-23H,1,6-9,11-14H2,2H3,(H2,30,31,34)
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US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284819
PNG
(1-((cis)-4-(5-(4-amino-5-(1-(tetrahydro-2H-pyran-4...)
Show SMILES C[C@H]1CN(C[C@@H](C)N1C(C)=O)c1cncc(c1)-c1cc(-c2ccnn2C2CCOCC2)c2c(N)ncnn12
Show InChI InChI=1S/C27H33N9O2/c1-17-14-33(15-18(2)34(17)19(3)37)22-10-20(12-29-13-22)25-11-23(26-27(28)30-16-32-36(25)26)24-4-7-31-35(24)21-5-8-38-9-6-21/h4,7,10-13,16-18,21H,5-6,8-9,14-15H2,1-3H3,(H2,28,30,32)/t17-,18+
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Bristol-Myers Squibb Company

US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284919
PNG
((S)-4-acetyl-1-(6-(4-amino-5- (trifluoromethyl)pyr...)
Show SMILES C[C@H]1CN(C(C)=O)C(C)(C)C(=O)N1c1cccc(n1)-c1cc(c2c(N)ncnn12)C(F)(F)F
Show InChI InChI=1S/C21H22F3N7O2/c1-11-9-29(12(2)32)20(3,4)19(33)30(11)16-7-5-6-14(28-16)15-8-13(21(22,23)24)17-18(25)26-10-27-31(15)17/h5-8,10-11H,9H2,1-4H3,(H2,25,26,27)/t11-/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284909
PNG
((R)-4-(5-(4-amino-5-(trifluoromethyl) pyrrolo[2,1-...)
Show SMILES C[C@@H]1COC(C)(C)C(=O)N1c1cc(cnc1C)-c1cc(c2c(N)ncnn12)C(F)(F)F
Show InChI InChI=1S/C20H21F3N6O2/c1-10-8-31-19(3,4)18(30)28(10)14-5-12(7-25-11(14)2)15-6-13(20(21,22)23)16-17(24)26-9-27-29(15)16/h5-7,9-10H,8H2,1-4H3,(H2,24,26,27)/t10-/m1/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284898
PNG
(1-(5-(4-amino-5-(1-(tetrahydro-2H- pyran-4-yl)-1H-...)
Show SMILES CC1(C)N(CCN(C1=O)c1cncc(c1)-c1cc(-c2ccnn2C2CCOCC2)c2c(N)ncnn12)C(=O)C1CC1
Show InChI InChI=1S/C29H33N9O3/c1-29(2)28(40)35(9-10-36(29)27(39)18-3-4-18)21-13-19(15-31-16-21)24-14-22(25-26(30)32-17-34-38(24)25)23-5-8-33-37(23)20-6-11-41-12-7-20/h5,8,13-18,20H,3-4,6-7,9-12H2,1-2H3,(H2,30,32,34)
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US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284890
PNG
(2-(6-(4-amino-5-(1-(tetrahydro-2H- pyran-4-yl)-1H-...)
Show SMILES NC(=O)c1ccccc1-n1ncc2ccc(cc12)-c1cc(-c2cnnn2C2CCOCC2)c2c(N)ncnn12
Show InChI InChI=1S/C27H24N10O2/c28-26-25-20(24-14-31-34-35(24)18-7-9-39-10-8-18)12-23(37(25)33-15-30-26)16-5-6-17-13-32-36(22(17)11-16)21-4-2-1-3-19(21)27(29)38/h1-6,11-15,18H,7-10H2,(H2,29,38)(H2,28,30,33)
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US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284864
PNG
(2-(6-(4-amino-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-p...)
Show SMILES NC(=O)c1ccccc1-n1ncc2ccc(cc12)-c1cc(-c2ccnn2C2CCOCC2)c2c(N)ncnn12
Show InChI InChI=1S/C28H25N9O2/c29-27-26-21(23-7-10-32-35(23)19-8-11-39-12-9-19)14-25(37(26)34-16-31-27)17-5-6-18-15-33-36(24(18)13-17)22-4-2-1-3-20(22)28(30)38/h1-7,10,13-16,19H,8-9,11-12H2,(H2,30,38)(H2,29,31,34)
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Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284855
PNG
(7-(1-(cyclopropylmethyl)-1H-benzo[d]imidazol-6-yl)...)
Show SMILES Nc1ncnn2c(cc(-c3cnnn3C3CCOCC3)c12)-c1ccc2ncn(CC3CC3)c2c1
Show InChI InChI=1S/C24H25N9O/c25-24-23-18(22-11-28-30-32(22)17-5-7-34-8-6-17)10-20(33(23)29-13-26-24)16-3-4-19-21(9-16)31(14-27-19)12-15-1-2-15/h3-4,9-11,13-15,17H,1-2,5-8,12H2,(H2,25,26,29)
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US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284907
PNG
((S)-4-(5-(4-amino-5-(trifluoromethyl) pyrrolo[2,1-...)
Show SMILES C[C@H]1COC(C)(C)C(=O)N1c1cc(cnc1C)-c1cc(c2c(N)ncnn12)C(F)(F)F
Show InChI InChI=1S/C20H21F3N6O2/c1-10-8-31-19(3,4)18(30)28(10)14-5-12(7-25-11(14)2)15-6-13(20(21,22)23)16-17(24)26-9-27-29(15)16/h5-7,9-10H,8H2,1-4H3,(H2,24,26,27)/t10-/m0/s1
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Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284838
PNG
(7-(3-methyl-1-(tetrahydro-2H-pyran-4-yl)-1H-indazo...)
Show SMILES Cc1nn(C2CCOCC2)c2cc(ccc12)-c1cc(-c2ccnn2C2CCOCC2)c2c(N)ncnn12
Show InChI InChI=1S/C27H30N8O2/c1-17-21-3-2-18(14-25(21)34(32-17)20-7-12-37-13-8-20)24-15-22(26-27(28)29-16-31-35(24)26)23-4-9-30-33(23)19-5-10-36-11-6-19/h2-4,9,14-16,19-20H,5-8,10-13H2,1H3,(H2,28,29,31)
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Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284834
PNG
(5-(1-(tetrahydro-2H-pyran-4-yl)-1H-1,2,3-triazol-5...)
Show SMILES Nc1ncnn2c(cc(-c3cnnn3C3CCOCC3)c12)-c1ccc2cnn(C3CCOCC3)c2c1
Show InChI InChI=1S/C25H27N9O2/c26-25-24-20(23-14-28-31-33(23)19-5-9-36-10-6-19)12-22(34(24)30-15-27-25)16-1-2-17-13-29-32(21(17)11-16)18-3-7-35-8-4-18/h1-2,11-15,18-19H,3-10H2,(H2,26,27,30)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284828
PNG
(5-(6-(4-Amino-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-p...)
Show SMILES CN1CC(CCC1=O)n1ncc2ccc(cc12)-c1cc(-c2ccnn2C2CCOCC2)c2c(N)ncnn12
Show InChI InChI=1S/C27H29N9O2/c1-33-15-20(4-5-25(33)37)35-23-12-17(2-3-18(23)14-31-35)24-13-21(26-27(28)29-16-32-36(24)26)22-6-9-30-34(22)19-7-10-38-11-8-19/h2-3,6,9,12-14,16,19-20H,4-5,7-8,10-11,15H2,1H3,(H2,28,29,32)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284843
PNG
(4-(6-(4-amino-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-p...)
Show SMILES Nc1ncnn2c(cc(-c3ccnn3C3CCCCC3)c12)-c1ccc2cnn(C3CCS(=O)(=O)CC3)c2c1
Show InChI InChI=1S/C27H30N8O2S/c28-27-26-22(23-8-11-30-33(23)20-4-2-1-3-5-20)15-25(35(26)32-17-29-27)18-6-7-19-16-31-34(24(19)14-18)21-9-12-38(36,37)13-10-21/h6-8,11,14-17,20-21H,1-5,9-10,12-13H2,(H2,28,29,32)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284841
PNG
(5-(1-(tetrahydro-2H-pyran-4-yl)-1H-1,2,3-triazol-5...)
Show SMILES Nc1ncnn2c(cc(-c3cnnn3C3CCOCC3)c12)-c1ccc2ncn(C3CCOCC3)c2c1
Show InChI InChI=1S/C25H27N9O2/c26-25-24-19(23-13-29-31-33(23)18-5-9-36-10-6-18)12-21(34(24)30-14-27-25)16-1-2-20-22(11-16)32(15-28-20)17-3-7-35-8-4-17/h1-2,11-15,17-18H,3-10H2,(H2,26,27,30)
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US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284897
PNG
(4-acetyl-1-(5-(4-amino-5- (trifluoromethyl)pyrrolo...)
Show SMILES CC(=O)N1CCN(C(=O)C1(C)C)c1cncc(c1)-c1cc(c2c(N)ncnn12)C(F)(F)F
Show InChI InChI=1S/C20H20F3N7O2/c1-11(31)29-5-4-28(18(32)19(29,2)3)13-6-12(8-25-9-13)15-7-14(20(21,22)23)16-17(24)26-10-27-30(15)16/h6-10H,4-5H2,1-3H3,(H2,24,26,27)
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US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284895
PNG
(1-(5-(4-amino-5-chloropyrrolo[2,1-f] [1,2,4]triazi...)
Show SMILES CC1(C)N(CCN(C1=O)c1cncc(c1)-c1cc(Cl)c2c(N)ncnn12)C(=O)C1CC1
Show InChI InChI=1S/C21H22ClN7O2/c1-21(2)20(31)27(5-6-28(21)19(30)12-3-4-12)14-7-13(9-24-10-14)16-8-15(22)17-18(23)25-11-26-29(16)17/h7-12H,3-6H2,1-2H3,(H2,23,25,26)
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Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284871
PNG
(7-(2-(piperazin-1-yl)pyridin-4-yl)-5- (1-(tetrahyd...)
Show SMILES Nc1ncnn2c(cc(-c3ccnn3C3CCOCC3)c12)-c1ccnc(c1)N1CCNCC1
Show InChI InChI=1S/C23H27N9O/c24-23-22-18(19-2-6-28-31(19)17-3-11-33-12-4-17)14-20(32(22)29-15-27-23)16-1-5-26-21(13-16)30-9-7-25-8-10-30/h1-2,5-6,13-15,17,25H,3-4,7-12H2,(H2,24,27,29)
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Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284864
PNG
(2-(6-(4-amino-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-p...)
Show SMILES NC(=O)c1ccccc1-n1ncc2ccc(cc12)-c1cc(-c2ccnn2C2CCOCC2)c2c(N)ncnn12
Show InChI InChI=1S/C28H25N9O2/c29-27-26-21(23-7-10-32-35(23)19-8-11-39-12-9-19)14-25(37(26)34-16-31-27)17-5-6-18-15-33-36(24(18)13-17)22-4-2-1-3-20(22)28(30)38/h1-7,10,13-16,19H,8-9,11-12H2,(H2,30,38)(H2,29,31,34)
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Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284875
PNG
(2-(4-(4-Amino-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-p...)
Show SMILES NC(=O)c1ccccc1-c1cc(ccn1)-c1cc(-c2ccnn2C2CCOCC2)c2c(N)ncnn12
Show InChI InChI=1S/C26H24N8O2/c27-25-24-20(22-6-10-31-33(22)17-7-11-36-12-8-17)14-23(34(24)32-15-30-25)16-5-9-29-21(13-16)18-3-1-2-4-19(18)26(28)35/h1-6,9-10,13-15,17H,7-8,11-12H2,(H2,28,35)(H2,27,30,32)
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US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284850
PNG
(4-(6-(4-amino-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-1...)
Show SMILES Nc1ncnn2c(cc(-c3cnnn3C3CCOCC3)c12)-c1ccc2ncn(C3CCS(=O)(=O)CC3)c2c1
Show InChI InChI=1S/C25H27N9O3S/c26-25-24-19(23-13-29-31-33(23)18-3-7-37-8-4-18)12-21(34(24)30-14-27-25)16-1-2-20-22(11-16)32(15-28-20)17-5-9-38(35,36)10-6-17/h1-2,11-15,17-18H,3-10H2,(H2,26,27,30)
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US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284894
PNG
((R)-4-acetyl-1-(4-(4-amino-5-(1-(1,1,1- trifluorop...)
Show SMILES C[C@@H](n1nccc1-c1cc(-c2ccnc(c2)N2CCN(C(C)=O)C(C)(C)C2=O)n2ncnc(N)c12)C(F)(F)F
Show InChI InChI=1S/C25H26F3N9O2/c1-14(25(26,27)28)36-18(6-8-32-36)17-12-19(37-21(17)22(29)31-13-33-37)16-5-7-30-20(11-16)34-9-10-35(15(2)38)24(3,4)23(34)39/h5-8,11-14H,9-10H2,1-4H3,(H2,29,31,33)/t14-/m1/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284876
PNG
(2-(5-(4-Amino-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-p...)
Show SMILES NC(=O)c1ccccc1-c1cncc(c1)-c1cc(-c2ccnn2C2CCOCC2)c2c(N)ncnn12
Show InChI InChI=1S/C26H24N8O2/c27-25-24-21(22-5-8-31-33(22)18-6-9-36-10-7-18)12-23(34(24)32-15-30-25)17-11-16(13-29-14-17)19-3-1-2-4-20(19)26(28)35/h1-5,8,11-15,18H,6-7,9-10H2,(H2,28,35)(H2,27,30,32)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284892
PNG
(4-acetyl-1-(5-(4-amino-5-chloropyrrolo [2,1-f][1,2...)
Show SMILES CC(=O)N1CCN(C(=O)C1(C)C)c1cncc(c1)-c1cc(Cl)c2c(N)ncnn12
Show InChI InChI=1S/C19H20ClN7O2/c1-11(28)26-5-4-25(18(29)19(26,2)3)13-6-12(8-22-9-13)15-7-14(20)16-17(21)23-10-24-27(15)16/h6-10H,4-5H2,1-3H3,(H2,21,23,24)
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US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284918
PNG
((S)-4-acetyl-1-(6-(4-amino-5-(1- methyl-1H-pyrazol...)
Show SMILES C[C@H]1CN(C(C)=O)C(C)(C)C(=O)N1c1cccc(n1)-c1cc(-c2cnn(C)c2)c2c(N)ncnn12
Show InChI InChI=1S/C24H27N9O2/c1-14-11-31(15(2)34)24(3,4)23(35)32(14)20-8-6-7-18(29-20)19-9-17(16-10-27-30(5)12-16)21-22(25)26-13-28-33(19)21/h6-10,12-14H,11H2,1-5H3,(H2,25,26,28)/t14-/m0/s1
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US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284857
PNG
(7-(1-((2,2-difluorocyclopropyl)methyl)-1H-indazol-...)
Show SMILES Nc1ncnn2c(cc(-c3cnnn3C3CCOCC3)c12)-c1ccc2ncn(CC3CC3(F)F)c2c1
Show InChI InChI=1S/C24H23F2N9O/c25-24(26)9-15(24)11-33-13-29-18-2-1-14(7-20(18)33)19-8-17(22-23(27)28-12-31-35(19)22)21-10-30-32-34(21)16-3-5-36-6-4-16/h1-2,7-8,10,12-13,15-16H,3-6,9,11H2,(H2,27,28,31)
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US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284878
PNG
(7-[1-(oxan-4-yl)-1H-indazol-6-yl]-5-[1- (propan-2-...)
Show SMILES CC(C)n1cc(cn1)-c1cc(-c2ccc3cnn(C4CCOCC4)c3c2)n2ncnc(N)c12
Show InChI InChI=1S/C24H26N8O/c1-15(2)30-13-18(12-27-30)20-10-22(32-23(20)24(25)26-14-29-32)16-3-4-17-11-28-31(21(17)9-16)19-5-7-33-8-6-19/h3-4,9-15,19H,5-8H2,1-2H3,(H2,25,26,29)
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Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284858
PNG
(7-(1-((2,2-difluorocyclopropyl)methyl)-1H-indazol-...)
Show SMILES Nc1ncnn2c(cc(-c3ccnn3C3CCOCC3)c12)-c1ccc2ncn(CC3CC3(F)F)c2c1
Show InChI InChI=1S/C25H24F2N8O/c26-25(27)11-16(25)12-33-14-30-19-2-1-15(9-22(19)33)21-10-18(23-24(28)29-13-32-35(21)23)20-3-6-31-34(20)17-4-7-36-8-5-17/h1-3,6,9-10,13-14,16-17H,4-5,7-8,11-12H2,(H2,28,29,32)
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Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284845
PNG
(4-(6-(4-amino-5-(1-cyclohexyl-1H-1,2,3-triazol-5-y...)
Show SMILES Nc1ncnn2c(cc(-c3cnnn3C3CCCCC3)c12)-c1ccc2cnn(C3CCS(=O)(=O)CC3)c2c1
Show InChI InChI=1S/C26H29N9O2S/c27-26-25-21(24-15-29-32-34(24)19-4-2-1-3-5-19)13-23(35(25)31-16-28-26)17-6-7-18-14-30-33(22(18)12-17)20-8-10-38(36,37)11-9-20/h6-7,12-16,19-20H,1-5,8-11H2,(H2,27,28,31)
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Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284873
PNG
(7-(2-(4-methylpiperazin-1-yl)pyridin- 4-yl)-5-(1-(...)
Show SMILES CN1CCN(CC1)c1cc(ccn1)-c1cc(-c2cnnn2C2CCOCC2)c2c(N)ncnn12
Show InChI InChI=1S/C23H28N10O/c1-30-6-8-31(9-7-30)21-12-16(2-5-25-21)19-13-18(22-23(24)26-15-28-33(19)22)20-14-27-29-32(20)17-3-10-34-11-4-17/h2,5,12-15,17H,3-4,6-11H2,1H3,(H2,24,26,28)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284888
PNG
(N-(5-{4-amino-7-[1-(1,1-dioxo-1lambda6- thian-4-yl...)
Show SMILES CC(=O)Nc1ccc(cn1)-c1cc(-c2ccc3cnn(C4CCS(=O)(=O)CC4)c3c2)n2ncnc(N)c12
Show InChI InChI=1S/C25H24N8O3S/c1-15(34)31-23-5-4-17(12-27-23)20-11-22(33-24(20)25(26)28-14-30-33)16-2-3-18-13-29-32(21(18)10-16)19-6-8-37(35,36)9-7-19/h2-5,10-14,19H,6-9H2,1H3,(H2,26,28,30)(H,27,31,34)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284920
PNG
((S)-4-(4-(4-amino-5-(1-(2,2,2- trifluoroethyl)-1H-...)
Show SMILES C[C@H]1COC(C)(C)C(=O)N1c1cc(ccn1)-c1cc(-c2ccnn2CC(F)(F)F)c2c(N)ncnn12
Show InChI InChI=1S/C23H23F3N8O2/c1-13-10-36-22(2,3)21(35)33(13)18-8-14(4-6-28-18)17-9-15(19-20(27)29-12-31-34(17)19)16-5-7-30-32(16)11-23(24,25)26/h4-9,12-13H,10-11H2,1-3H3,(H2,27,29,31)/t13-/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284828
PNG
(5-(6-(4-Amino-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-p...)
Show SMILES CN1CC(CCC1=O)n1ncc2ccc(cc12)-c1cc(-c2ccnn2C2CCOCC2)c2c(N)ncnn12
Show InChI InChI=1S/C27H29N9O2/c1-33-15-20(4-5-25(33)37)35-23-12-17(2-3-18(23)14-31-35)24-13-21(26-27(28)29-16-32-36(24)26)22-6-9-30-34(22)19-7-10-38-11-8-19/h2-3,6,9,12-14,16,19-20H,4-5,7-8,10-11,15H2,1H3,(H2,28,29,32)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284896
PNG
(1-(5-(4-amino-5-(1-(2,2,2- trifluoroethyl)-1H-pyra...)
Show SMILES CC1(C)N(CCN(C1=O)c1cncc(c1)-c1cc(-c2ccnn2CC(F)(F)F)c2c(N)ncnn12)C(=O)C1CC1
Show InChI InChI=1S/C26H26F3N9O2/c1-25(2)24(40)35(7-8-36(25)23(39)15-3-4-15)17-9-16(11-31-12-17)20-10-18(21-22(30)32-14-34-38(20)21)19-5-6-33-37(19)13-26(27,28)29/h5-6,9-12,14-15H,3-4,7-8,13H2,1-2H3,(H2,30,32,34)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284820
PNG
(1-((cis)-4-(5-(4-amino-5-(1-(tetrahydro-2H-pyran-4...)
Show SMILES C[C@H]1CN(C[C@@H](C)N1C(C)=O)c1cncc(c1)-c1cc(-c2cnnn2C2CCOCC2)c2c(N)ncnn12
Show InChI InChI=1S/C26H32N10O2/c1-16-13-33(14-17(2)34(16)18(3)37)21-8-19(10-28-11-21)23-9-22(25-26(27)29-15-31-36(23)25)24-12-30-32-35(24)20-4-6-38-7-5-20/h8-12,15-17,20H,4-7,13-14H2,1-3H3,(H2,27,29,31)/t16-,17+
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Bristol-Myers Squibb Company

US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284879
PNG
(4-(6-{4-amino-5-[1-(propan-2-yl)-1H- pyrazol-4-yl]...)
Show SMILES CC(C)n1cc(cn1)-c1cc(-c2ccc3cnn(C4CCS(=O)(=O)CC4)c3c2)n2ncnc(N)c12
Show InChI InChI=1S/C24H26N8O2S/c1-15(2)30-13-18(12-27-30)20-10-22(32-23(20)24(25)26-14-29-32)16-3-4-17-11-28-31(21(17)9-16)19-5-7-35(33,34)8-6-19/h3-4,9-15,19H,5-8H2,1-2H3,(H2,25,26,29)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284870
PNG
(4-(7-(4-amino-5-(1-(tetrahydro-2H- pyran-4-yl)-1H-...)
Show SMILES Nc1ncnn2c(cc(-c3cnnn3C3CCOCC3)c12)-c1ccc2ccnc(N3CCS(=O)(=O)CC3)c2c1
Show InChI InChI=1S/C26H27N9O3S/c27-25-24-21(23-15-30-32-34(23)19-4-9-38-10-5-19)14-22(35(24)31-16-29-25)18-2-1-17-3-6-28-26(20(17)13-18)33-7-11-39(36,37)12-8-33/h1-3,6,13-16,19H,4-5,7-12H2,(H2,27,29,31)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284832
PNG
(1-(4-(6-(4-amino-5-(1-(tetrahydro-2H-pyran-4-yl)-1...)
Show SMILES Cc1nc2ccc(cc2n1C1CCN(CC1)C(=O)CO)-c1cc(-c2ccnn2C2CCOCC2)c2c(N)ncnn12
Show InChI InChI=1S/C29H33N9O3/c1-18-34-23-3-2-19(14-26(23)36(18)20-5-10-35(11-6-20)27(40)16-39)25-15-22(28-29(30)31-17-33-38(25)28)24-4-9-32-37(24)21-7-12-41-13-8-21/h2-4,9,14-15,17,20-21,39H,5-8,10-13,16H2,1H3,(H2,30,31,33)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284847
PNG
(4-(6-(4-amino-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-p...)
Show SMILES Nc1ncnn2c(cc(-c3ccnn3C3CCOCC3)c12)-c1cc(F)c2cnn(C3CCS(=O)(=O)CC3)c2c1
Show InChI InChI=1S/C26H27FN8O3S/c27-21-11-16(12-24-20(21)14-31-34(24)18-4-9-39(36,37)10-5-18)23-13-19(25-26(28)29-15-32-35(23)25)22-1-6-30-33(22)17-2-7-38-8-3-17/h1,6,11-15,17-18H,2-5,7-10H2,(H2,28,29,32)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284815
PNG
(1-(4-(5-(4-amino-5-(1-isopropyl-1H-1,2,3-triazol-5...)
Show SMILES CC(C)n1nncc1-c1cc(-c2cncc(c2)N2CCN(CC2)C(C)=O)n2ncnc(N)c12
Show InChI InChI=1S/C22H26N10O/c1-14(2)31-20(12-26-28-31)18-9-19(32-21(18)22(23)25-13-27-32)16-8-17(11-24-10-16)30-6-4-29(5-7-30)15(3)33/h8-14H,4-7H2,1-3H3,(H2,23,25,27)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284833
PNG
(1-(4-(6-(4-amino-5-(1-(tetrahydro-2H-pyran-4-yl)-1...)
Show SMILES COCC(=O)N1CCC(CC1)n1c(C)nc2ccc(cc12)-c1cc(-c2ccnn2C2CCOCC2)c2c(N)ncnn12
Show InChI InChI=1S/C30H35N9O3/c1-19-35-24-4-3-20(15-27(24)37(19)21-6-11-36(12-7-21)28(40)17-41-2)26-16-23(29-30(31)32-18-34-39(26)29)25-5-10-33-38(25)22-8-13-42-14-9-22/h3-5,10,15-16,18,21-22H,6-9,11-14,17H2,1-2H3,(H2,31,32,34)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284854
PNG
(7-(1-(cyclopropylmethyl)-1H-indazol-6-yl)-5-(1-(te...)
Show SMILES Nc1ncnn2c(cc(-c3ccnn3C3CCOCC3)c12)-c1ccc2cnn(CC3CC3)c2c1
Show InChI InChI=1S/C25H26N8O/c26-25-24-20(21-5-8-28-32(21)19-6-9-34-10-7-19)12-23(33(24)30-15-27-25)17-3-4-18-13-29-31(22(18)11-17)14-16-1-2-16/h3-5,8,11-13,15-16,19H,1-2,6-7,9-10,14H2,(H2,26,27,30)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284874
PNG
(1-(4-(4-(4-amino-5-(1-(tetrahydro- 2H-pyran-4-yl)-...)
Show SMILES CC(=O)N1CCN(CC1)c1cc(ccn1)-c1cc(-c2ccnn2C2CCOCC2)c2c(N)ncnn12
Show InChI InChI=1S/C25H29N9O2/c1-17(35)31-8-10-32(11-9-31)23-14-18(2-6-27-23)22-15-20(24-25(26)28-16-30-34(22)24)21-3-7-29-33(21)19-4-12-36-13-5-19/h2-3,6-7,14-16,19H,4-5,8-13H2,1H3,(H2,26,28,30)
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US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284817
PNG
(4-(5-(4-amino-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-1...)
Show SMILES Nc1ncnn2c(cc(-c3cnnn3C3CCOCC3)c12)-c1cncc(c1)N1CCS(=O)(=O)CC1
Show InChI InChI=1S/C22H25N9O3S/c23-22-21-18(20-13-26-28-30(20)16-1-5-34-6-2-16)10-19(31(21)27-14-25-22)15-9-17(12-24-11-15)29-3-7-35(32,33)8-4-29/h9-14,16H,1-8H2,(H2,23,25,27)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284862
PNG
((R)-5-((6-(4-amino-5-(1-(tetrahydro-2H-pyran-4-yl)...)
Show SMILES Nc1ncnn2c(cc(-c3ccnn3C3CCOCC3)c12)-c1ccc2ncn(C[C@H]3CCC(=O)N3)c2c1
Show InChI InChI=1S/C26H27N9O2/c27-26-25-19(21-5-8-30-34(21)18-6-9-37-10-7-18)12-22(35(25)31-14-28-26)16-1-3-20-23(11-16)33(15-29-20)13-17-2-4-24(36)32-17/h1,3,5,8,11-12,14-15,17-18H,2,4,6-7,9-10,13H2,(H,32,36)(H2,27,28,31)/t17-/m1/s1
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US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284869
PNG
(4-(7-(4-amino-5-(1-isopropyl-1H- 1,2,3-triazol-5-y...)
Show SMILES CC(C)n1nncc1-c1cc(-c2ccc3ccnc(N4CCS(=O)(=O)CC4)c3c2)n2ncnc(N)c12
Show InChI InChI=1S/C24H25N9O2S/c1-15(2)32-21(13-28-30-32)19-12-20(33-22(19)23(25)27-14-29-33)17-4-3-16-5-6-26-24(18(16)11-17)31-7-9-36(34,35)10-8-31/h3-6,11-15H,7-10H2,1-2H3,(H2,25,27,29)
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US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284814
PNG
(1-(4-(5-(4-amino-5-(1-(tetrahydro-2H-pyran-4-yl)-1...)
Show SMILES CC(=O)N1CCN(CC1)c1cncc(c1)-c1cc(-c2cnnn2C2CCOCC2)c2c(N)ncnn12
Show InChI InChI=1S/C24H28N10O2/c1-16(35)31-4-6-32(7-5-31)19-10-17(12-26-13-19)21-11-20(23-24(25)27-15-29-34(21)23)22-14-28-30-33(22)18-2-8-36-9-3-18/h10-15,18H,2-9H2,1H3,(H2,25,27,29)
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Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284811
PNG
(1-(4-(5-(4-Amino-5-(1-(tetrahydro-2H-pyran-4-yl)-1...)
Show SMILES CC(=O)N1CCN(CC1)c1cncc(c1)-c1cc(-c2ccnn2C2CCOCC2)c2c(N)ncnn12
Show InChI InChI=1S/C25H29N9O2/c1-17(35)31-6-8-32(9-7-31)20-12-18(14-27-15-20)23-13-21(24-25(26)28-16-30-34(23)24)22-2-5-29-33(22)19-3-10-36-11-4-19/h2,5,12-16,19H,3-4,6-11H2,1H3,(H2,26,28,30)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284861
PNG
(2-(6-(4-amino-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-p...)
Show SMILES CN(C)C(=O)Cn1cnc2ccc(cc12)-c1cc(-c2ccnn2C2CCOCC2)c2c(N)ncnn12
Show InChI InChI=1S/C25H27N9O2/c1-31(2)23(35)13-32-15-28-19-4-3-16(11-22(19)32)21-12-18(24-25(26)27-14-30-34(21)24)20-5-8-29-33(20)17-6-9-36-10-7-17/h3-5,8,11-12,14-15,17H,6-7,9-10,13H2,1-2H3,(H2,26,27,30)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284877
PNG
(7-(2-(2-(Methylsulfonyl)phenyl)pyridin-4-yl)-5-(1-...)
Show SMILES CS(=O)(=O)c1ccccc1-c1cc(ccn1)-c1cc(-c2ccnn2C2CCOCC2)c2c(N)ncnn12
Show InChI InChI=1S/C26H25N7O3S/c1-37(34,35)24-5-3-2-4-19(24)21-14-17(6-10-28-21)23-15-20(25-26(27)29-16-31-33(23)25)22-7-11-30-32(22)18-8-12-36-13-9-18/h2-7,10-11,14-16,18H,8-9,12-13H2,1H3,(H2,27,29,31)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284816
PNG
(4-(5-(4-amino-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-p...)
Show SMILES Nc1ncnn2c(cc(-c3ccnn3C3CCOCC3)c12)-c1cncc(c1)N1CCS(=O)(=O)CC1
Show InChI InChI=1S/C23H26N8O3S/c24-23-22-19(20-1-4-27-30(20)17-2-7-34-8-3-17)12-21(31(22)28-15-26-23)16-11-18(14-25-13-16)29-5-9-35(32,33)10-6-29/h1,4,11-15,17H,2-3,5-10H2,(H2,24,26,28)
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US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284827
PNG
(7-(1-(2-Fluoroethyl)-1H-indazol-6-yl)-5-(1-(tetrah...)
Show SMILES Nc1ncnn2c(cc(-c3ccnn3C3CCOCC3)c12)-c1ccc2cnn(CCF)c2c1
Show InChI InChI=1S/C23H23FN8O/c24-6-8-30-20-11-15(1-2-16(20)13-28-30)21-12-18(22-23(25)26-14-29-32(21)22)19-3-7-27-31(19)17-4-9-33-10-5-17/h1-3,7,11-14,17H,4-6,8-10H2,(H2,25,26,29)
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US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284853
PNG
(7-(1-(cyclopropylmethyl)-1H-indazol-6-yl)-5-(1-(te...)
Show SMILES Nc1ncnn2c(cc(-c3cnnn3C3CCOCC3)c12)-c1ccc2cnn(CC3CC3)c2c1
Show InChI InChI=1S/C24H25N9O/c25-24-23-19(22-12-27-30-32(22)18-5-7-34-8-6-18)10-21(33(23)29-14-26-24)16-3-4-17-11-28-31(20(17)9-16)13-15-1-2-15/h3-4,9-12,14-15,18H,1-2,5-8,13H2,(H2,25,26,29)
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US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284865
PNG
(N-(2-(6-(4-amino-5-(1-(tetrahydro-2H-pyran-4-yl)-1...)
Show SMILES CC(=O)Nc1ccccc1-n1ncc2ccc(cc12)-c1cc(-c2ccnn2C2CCOCC2)c2c(N)ncnn12
Show InChI InChI=1S/C29H27N9O2/c1-18(39)35-23-4-2-3-5-25(23)37-26-14-19(6-7-20(26)16-33-37)27-15-22(28-29(30)31-17-34-38(27)28)24-8-11-32-36(24)21-9-12-40-13-10-21/h2-8,11,14-17,21H,9-10,12-13H2,1H3,(H,35,39)(H2,30,31,34)
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US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284880
PNG
(5-(1-methyl-1H-pyrazol-4-yl)-7-[1- (oxan-4-yl)-1H-...)
Show SMILES Cn1cc(cn1)-c1cc(-c2ccc3cnn(C4CCOCC4)c3c2)n2ncnc(N)c12
Show InChI InChI=1S/C22H22N8O/c1-28-12-16(11-25-28)18-9-20(30-21(18)22(23)24-13-27-30)14-2-3-15-10-26-29(19(15)8-14)17-4-6-31-7-5-17/h2-3,8-13,17H,4-7H2,1H3,(H2,23,24,27)
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US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284913
PNG
((S)-4-(5-(4-amino-5-(1-(2,2,2- trifluoroethyl)-1H-...)
Show SMILES C[C@H]1COC(C)(C)C(=O)N1c1cc(cnc1C)-c1cc(-c2ccnn2CC(F)(F)F)c2c(N)ncnn12
Show InChI InChI=1S/C24H25F3N8O2/c1-13-10-37-23(3,4)22(36)34(13)18-7-15(9-29-14(18)2)19-8-16(20-21(28)30-12-32-35(19)20)17-5-6-31-33(17)11-24(25,26)27/h5-9,12-13H,10-11H2,1-4H3,(H2,28,30,32)/t13-/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284836
PNG
(5-(1-cyclohexyl-1H-1,2,3-triazol-5-yl)-7-(1-(tetra...)
Show SMILES Nc1ncnn2c(cc(-c3cnnn3C3CCCCC3)c12)-c1ccc2cnn(C3CCOCC3)c2c1
Show InChI InChI=1S/C26H29N9O/c27-26-25-21(24-15-29-32-34(24)19-4-2-1-3-5-19)13-23(35(25)31-16-28-26)17-6-7-18-14-30-33(22(18)12-17)20-8-10-36-11-9-20/h6-7,12-16,19-20H,1-5,8-11H2,(H2,27,28,31)
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US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284860
PNG
(1-(6-(4-amino-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-1...)
Show SMILES Nc1ncnn2c(cc(-c3cnnn3C3CCOCC3)c12)-c1ccc2ncn(CC(O)CF)c2c1
Show InChI InChI=1S/C23H24FN9O2/c24-9-16(34)11-31-13-27-18-2-1-14(7-20(18)31)19-8-17(22-23(25)26-12-29-33(19)22)21-10-28-30-32(21)15-3-5-35-6-4-15/h1-2,7-8,10,12-13,15-16,34H,3-6,9,11H2,(H2,25,26,29)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284844
PNG
(4-(6-(4-amino-5-(1-(2,2,2-trifluoroethyl)-1H-pyraz...)
Show SMILES Nc1ncnn2c(cc(-c3ccnn3CC(F)(F)F)c12)-c1ccc2cnn(C3CCS(=O)(=O)CC3)c2c1
Show InChI InChI=1S/C23H21F3N8O2S/c24-23(25,26)12-32-18(3-6-29-32)17-10-20(34-21(17)22(27)28-13-31-34)14-1-2-15-11-30-33(19(15)9-14)16-4-7-37(35,36)8-5-16/h1-3,6,9-11,13,16H,4-5,7-8,12H2,(H2,27,28,31)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284852
PNG
(7-(1-isopropyl-1H-indazol-6-yl)-5-(1-(tetrahydro-2...)
Show SMILES CC(C)n1ncc2ccc(cc12)-c1cc(-c2ccnn2C2CCOCC2)c2c(N)ncnn12
Show InChI InChI=1S/C24H26N8O/c1-15(2)30-21-11-16(3-4-17(21)13-28-30)22-12-19(23-24(25)26-14-29-32(22)23)20-5-8-27-31(20)18-6-9-33-10-7-18/h3-5,8,11-15,18H,6-7,9-10H2,1-2H3,(H2,25,26,29)
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US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284868
PNG
(7-(1-morpholinoisoquinolin-7-yl)-5- (1-(tetrahydro...)
Show SMILES Nc1ncnn2c(cc(-c3cnnn3C3CCOCC3)c12)-c1ccc2ccnc(N3CCOCC3)c2c1
Show InChI InChI=1S/C26H27N9O2/c27-25-24-21(23-15-30-32-34(23)19-4-9-36-10-5-19)14-22(35(24)31-16-29-25)18-2-1-17-3-6-28-26(20(17)13-18)33-7-11-37-12-8-33/h1-3,6,13-16,19H,4-5,7-12H2,(H2,27,29,31)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284881
PNG
(7-(1H-indazol-6-yl)-5-[1-(oxan-4-yl)- 1H-pyrazol-5...)
Show SMILES Nc1ncnn2c(cc(-c3ccnn3C3CCOCC3)c12)-c1ccc2cn[nH]c2c1
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US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284813
PNG
(5-(1-cyclohexyl-1H-pyrazol-5-yl)-7-(1-methyl- 1H-b...)
Show SMILES Cn1cnc2ccc(cc12)-c1cc(-c2ccnn2C2CCCCC2)c2c(N)ncnn12
Show InChI InChI=1S/C23H24N8/c1-29-14-26-18-8-7-15(11-21(18)29)20-12-17(22-23(24)25-13-28-31(20)22)19-9-10-27-30(19)16-5-3-2-4-6-16/h7-14,16H,2-6H2,1H3,(H2,24,25,28)
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US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284887
PNG
(N-(5-{4-amino-7-[1-(oxan-4-yl)-1H- indazol-6-yl]py...)
Show SMILES CC(=O)Nc1ccc(cn1)-c1cc(-c2ccc3cnn(C4CCOCC4)c3c2)n2ncnc(N)c12
Show InChI InChI=1S/C25H24N8O2/c1-15(34)31-23-5-4-17(12-27-23)20-11-22(33-24(20)25(26)28-14-30-33)16-2-3-18-13-29-32(21(18)10-16)19-6-8-35-9-7-19/h2-5,10-14,19H,6-9H2,1H3,(H2,26,28,30)(H,27,31,34)
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US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284867
PNG
(1-(4-(7-(4-Amino-5-(1-(tetrahydro-2H-pyran-4-yl)-1...)
Show SMILES CC(=O)N1CCN(CC1)c1nccc2ccc(cc12)-c1cc(-c2cnnn2C2CCOCC2)c2c(N)ncnn12
Show InChI InChI=1S/C28H30N10O2/c1-18(39)35-8-10-36(11-9-35)28-22-14-20(3-2-19(22)4-7-30-28)24-15-23(26-27(29)31-17-33-38(24)26)25-16-32-34-37(25)21-5-12-40-13-6-21/h2-4,7,14-17,21H,5-6,8-13H2,1H3,(H2,29,31,33)
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Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284851
PNG
(4-(6-(4-amino-5-(1-(2,2,2-trifluoroethyl)-1H-pyraz...)
Show SMILES Nc1ncnn2c(cc(-c3ccnn3CC(F)(F)F)c12)-c1ccc2ncn(C3CCS(=O)(=O)CC3)c2c1
Show InChI InChI=1S/C23H21F3N8O2S/c24-23(25,26)11-33-18(3-6-30-33)16-10-19(34-21(16)22(27)28-12-31-34)14-1-2-17-20(9-14)32(13-29-17)15-4-7-37(35,36)8-5-15/h1-3,6,9-10,12-13,15H,4-5,7-8,11H2,(H2,27,28,31)
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Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284866
PNG
(3-(6-(4-amino-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-p...)
Show SMILES NC(=O)c1cccc(c1)-n1ncc2ccc(cc12)-c1cc(-c2ccnn2C2CCOCC2)c2c(N)ncnn12
Show InChI InChI=1S/C28H25N9O2/c29-27-26-22(23-6-9-32-35(23)20-7-10-39-11-8-20)14-25(37(26)34-16-31-27)17-4-5-19-15-33-36(24(19)13-17)21-3-1-2-18(12-21)28(30)38/h1-6,9,12-16,20H,7-8,10-11H2,(H2,30,38)(H2,29,31,34)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284859
PNG
(1-(6-(4-amino-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-p...)
Show SMILES Nc1ncnn2c(cc(-c3ccnn3C3CCOCC3)c12)-c1ccc2ncn(CC(O)CF)c2c1
Show InChI InChI=1S/C24H25FN8O2/c25-11-17(34)12-31-14-28-19-2-1-15(9-22(19)31)21-10-18(23-24(26)27-13-30-33(21)23)20-3-6-29-32(20)16-4-7-35-8-5-16/h1-3,6,9-10,13-14,16-17,34H,4-5,7-8,11-12H2,(H2,26,27,30)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284863
PNG
(7-(1-((5-methylisoxazol-3-yl)methyl)-1H-indazol-6-...)
Show SMILES CC(c1cc(C)on1)n1cnc2ccc(cc12)-c1cc(-c2ccnn2C2CCOCC2)c2c(N)ncnn12
Show InChI InChI=1S/C27H27N9O2/c1-16-11-22(33-38-16)17(2)34-15-30-21-4-3-18(12-25(21)34)24-13-20(26-27(28)29-14-32-36(24)26)23-5-8-31-35(23)19-6-9-37-10-7-19/h3-5,8,11-15,17,19H,6-7,9-10H2,1-2H3,(H2,28,29,32)
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US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284908
PNG
((R)-4-(5-(4-amino-5-chloro-6- fluoropyrrolo[2,1-f]...)
Show SMILES C[C@@H]1COC(C)(C)C(=O)N1c1cc(cnc1C)-c1c(F)c(Cl)c2c(N)ncnn12
Show InChI InChI=1S/C19H20ClFN6O2/c1-9-7-29-19(3,4)18(28)26(9)12-5-11(6-23-10(12)2)15-14(21)13(20)16-17(22)24-8-25-27(15)16/h5-6,8-9H,7H2,1-4H3,(H2,22,24,25)/t9-/m1/s1
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US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284882
PNG
(4-amino-7-[1-(oxan-4-yl)-1H-indazol- 6-yl]pyrrolo[...)
Show SMILES Nc1ncnn2c(cc(C#N)c12)-c1ccc2cnn(C3CCOCC3)c2c1
Show InChI InChI=1S/C19H17N7O/c20-9-14-8-16(26-18(14)19(21)22-11-24-26)12-1-2-13-10-23-25(17(13)7-12)15-3-5-27-6-4-15/h1-2,7-8,10-11,15H,3-6H2,(H2,21,22,24)
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Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284903
PNG
((R)-4-(5-(4-amino-5-chloropyrrolo[2,1- f][1,2,4]tr...)
Show SMILES C[C@@H]1CN(C(=O)C(C)(C)O1)c1cc(cnc1C)-c1cc(Cl)c2c(N)ncnn12
Show InChI InChI=1S/C19H21ClN6O2/c1-10-8-25(18(27)19(3,4)28-10)14-5-12(7-22-11(14)2)15-6-13(20)16-17(21)23-9-24-26(15)16/h5-7,9-10H,8H2,1-4H3,(H2,21,23,24)/t10-/m1/s1
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Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284848
PNG
(4-(6-(4-amino-5-(1-cyclopropyl-1H-pyrazol-5-yl)pyr...)
Show SMILES Nc1ncnn2c(cc(-c3ccnn3C3CC3)c12)-c1cc(F)c2cnn(C3CCS(=O)(=O)CC3)c2c1
Show InChI InChI=1S/C24H23FN8O2S/c25-19-9-14(10-22-18(19)12-29-32(22)16-4-7-36(34,35)8-5-16)21-11-17(23-24(26)27-13-30-33(21)23)20-3-6-28-31(20)15-1-2-15/h3,6,9-13,15-16H,1-2,4-5,7-8H2,(H2,26,27,30)
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Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284915
PNG
((S)-4-(5-(4-amino-5-(1-(2,2,2- trifluoroethyl)-1H-...)
Show SMILES C[C@H]1CN(C(=O)C(C)(C)O1)c1cc(cnc1C)-c1cc(-c2ccnn2CC(F)(F)F)c2c(N)ncnn12
Show InChI InChI=1S/C24H25F3N8O2/c1-13-10-33(22(36)23(3,4)37-13)18-7-15(9-29-14(18)2)19-8-16(20-21(28)30-12-32-35(19)20)17-5-6-31-34(17)11-24(25,26)27/h5-9,12-13H,10-11H2,1-4H3,(H2,28,30,32)/t13-/m0/s1
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US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284914
PNG
((S)-4-acetyl-1-(6-(4-amino-5- chloropyrrolo[2,1-f]...)
Show SMILES C[C@H]1CN(C(C)=O)C(C)(C)C(=O)N1c1cccc(n1)-c1cc(Cl)c2c(N)ncnn12
Show InChI InChI=1S/C20H22ClN7O2/c1-11-9-26(12(2)29)20(3,4)19(30)27(11)16-7-5-6-14(25-16)15-8-13(21)17-18(22)23-10-24-28(15)17/h5-8,10-11H,9H2,1-4H3,(H2,22,23,24)/t11-/m0/s1
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US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284905
PNG
((R)-4-(5-(4-amino-5-(1-(2,2,2- trifluoroethyl)-1H-...)
Show SMILES C[C@@H]1COC(C)(C)C(=O)N1c1cc(cnc1C)-c1cc(-c2ccnn2CC(F)(F)F)c2c(N)ncnn12
Show InChI InChI=1S/C24H25F3N8O2/c1-13-10-37-23(3,4)22(36)34(13)18-7-15(9-29-14(18)2)19-8-16(20-21(28)30-12-32-35(19)20)17-5-6-31-33(17)11-24(25,26)27/h5-9,12-13H,10-11H2,1-4H3,(H2,28,30,32)/t13-/m1/s1
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US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284812
PNG
(5-(4-amino-5-(1-cyclohexyl-1H-pyrazol-5-yl) pyrrol...)
Show SMILES Nc1ncnn2c(cc(-c3ccnn3C3CCCCC3)c12)-c1ccc2[nH]c(=O)[nH]c2c1
Show InChI InChI=1S/C22H20N8O/c23-21-20-15(18-8-9-25-29(18)14-4-2-1-3-5-14)11-19(30(20)26-12-24-21)13-6-7-16-17(10-13)28-22(31)27-16/h6-12,14H,1-5H2,(H2,23,24,26)
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US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284883
PNG
(4-{6-[4-amino-5-(1-methyl-1H- pyrazol-4-yl)pyrrolo...)
Show SMILES Cn1cc(cn1)-c1cc(-c2ccc3cnn(C4CCS(=O)(=O)CC4)c3c2)n2ncnc(N)c12
Show InChI InChI=1S/C22H22N8O2S/c1-28-12-16(11-25-28)18-9-20(30-21(18)22(23)24-13-27-30)14-2-3-15-10-26-29(19(15)8-14)17-4-6-33(31,32)7-5-17/h2-3,8-13,17H,4-7H2,1H3,(H2,23,24,27)
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US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284904
PNG
((S)-4-acetyl-1-(4-(4-amino-5-(1-(2,2,2- trifluoroe...)
Show SMILES C[C@H]1CN(C(C)=O)C(C)(C)C(=O)N1c1cc(ccn1)-c1cc(-c2ccnn2CC(F)(F)F)c2c(N)ncnn12
Show InChI InChI=1S/C25H26F3N9O2/c1-14-11-34(15(2)38)24(3,4)23(39)36(14)20-9-16(5-7-30-20)19-10-17(21-22(29)31-13-33-37(19)21)18-6-8-32-35(18)12-25(26,27)28/h5-10,13-14H,11-12H2,1-4H3,(H2,29,31,33)/t14-/m0/s1
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Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284916
PNG
((S)-4-acetyl-1-(6-(4-amino-5-(1-(2,2,2- trifluoroe...)
Show SMILES C[C@H]1CN(C(C)=O)C(C)(C)C(=O)N1c1cccc(n1)-c1cc(-c2ccnn2CC(F)(F)F)c2c(N)ncnn12
Show InChI InChI=1S/C25H26F3N9O2/c1-14-11-34(15(2)38)24(3,4)23(39)36(14)20-7-5-6-17(33-20)19-10-16(21-22(29)30-13-32-37(19)21)18-8-9-31-35(18)12-25(26,27)28/h5-10,13-14H,11-12H2,1-4H3,(H2,29,30,32)/t14-/m0/s1
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US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284884
PNG
(5-iodo-7-[1-(oxan-4-yl)-1H-indazol-6- yl]pyrrolo[2...)
Show SMILES Nc1ncnn2c(cc(I)c12)-c1ccc2cnn(C3CCOCC3)c2c1
Show InChI InChI=1S/C18H17IN6O/c19-14-8-16(25-17(14)18(20)21-10-23-25)11-1-2-12-9-22-24(15(12)7-11)13-3-5-26-6-4-13/h1-2,7-10,13H,3-6H2,(H2,20,21,23)
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US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284891
PNG
(7-(5-bromopyridin-3-yl)-5-[1-(oxan-4- yl)-1H-pyraz...)
Show SMILES Nc1ncnn2c(cc(-c3ccnn3C3CCOCC3)c12)-c1cncc(Br)c1
Show InChI InChI=1S/C19H18BrN7O/c20-13-7-12(9-22-10-13)17-8-15(18-19(21)23-11-25-27(17)18)16-1-4-24-26(16)14-2-5-28-6-3-14/h1,4,7-11,14H,2-3,5-6H2,(H2,21,23,25)
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Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284911
PNG
((S)-4-(5-(4-amino-5-(trifluoromethyl) pyrrolo[2,1-...)
Show SMILES C[C@H]1CN(C(=O)C(C)(C)O1)c1cc(cnc1C)-c1cc(c2c(N)ncnn12)C(F)(F)F
Show InChI InChI=1S/C20H21F3N6O2/c1-10-8-28(18(30)19(3,4)31-10)14-5-12(7-25-11(14)2)15-6-13(20(21,22)23)16-17(24)26-9-27-29(15)16/h5-7,9-10H,8H2,1-4H3,(H2,24,26,27)/t10-/m0/s1
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Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284885
PNG
(5-chloro-7-[1-(oxan-4-yl)-1H-indazol- 6-yl]pyrrolo...)
Show SMILES Nc1ncnn2c(cc(Cl)c12)-c1ccc2cnn(C3CCOCC3)c2c1
Show InChI InChI=1S/C18H17ClN6O/c19-14-8-16(25-17(14)18(20)21-10-23-25)11-1-2-12-9-22-24(15(12)7-11)13-3-5-26-6-4-13/h1-2,7-10,13H,3-6H2,(H2,20,21,23)
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Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284886
PNG
(5-bromo-7-[1-(oxan-4-yl)-1H-indazol- 6-yl]pyrrolo[...)
Show SMILES Nc1ncnn2c(cc(Br)c12)-c1ccc2cnn(C3CCOCC3)c2c1
Show InChI InChI=1S/C18H17BrN6O/c19-14-8-16(25-17(14)18(20)21-10-23-25)11-1-2-12-9-22-24(15(12)7-11)13-3-5-26-6-4-13/h1-2,7-10,13H,3-6H2,(H2,20,21,23)
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n/an/a 64n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284921
PNG
((4-(4-amino-5-(trifluoromethyl) pyrrolo[2,1-f][1,2...)
Show SMILES Nc1ncnn2c(cc(c12)C(F)(F)F)N1CCOC(C1)C(=O)N1CCCC1
Show InChI InChI=1S/C16H19F3N6O2/c17-16(18,19)10-7-12(25-13(10)14(20)21-9-22-25)24-5-6-27-11(8-24)15(26)23-3-1-2-4-23/h7,9,11H,1-6,8H2,(H2,20,21,22)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284923
PNG
(4-(4-amino-5-(trifluoromethyl) pyrrolo[2,1-f][1,2,...)
Show SMILES Nc1ncnn2c(cc(c12)C(F)(F)F)N1CCOC(C1)C(=O)NC1CCCCC1
Show InChI InChI=1S/C18H23F3N6O2/c19-18(20,21)12-8-14(27-15(12)16(22)23-10-24-27)26-6-7-29-13(9-26)17(28)25-11-4-2-1-3-5-11/h8,10-11,13H,1-7,9H2,(H,25,28)(H2,22,23,24)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284926
PNG
(1-(4-amino-5-(trifluoromethyl) pyrrolo[2,1-f][1,2,...)
Show SMILES Nc1ncnn2c(cc(c12)C(F)(F)F)N1CCCC(C1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C19H19F3N6O/c20-19(21,22)14-9-15(28-16(14)17(23)24-11-25-28)27-8-4-5-12(10-27)18(29)26-13-6-2-1-3-7-13/h1-3,6-7,9,11-12H,4-5,8,10H2,(H,26,29)(H2,23,24,25)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284927
PNG
(1-(4-amino-5-(trifluoromethyl) pyrrolo[2,1-f][1,2,...)
Show SMILES CC(C)NC(=O)C1CCCN(C1)c1cc(c2c(N)ncnn12)C(F)(F)F
Show InChI InChI=1S/C16H21F3N6O/c1-9(2)23-15(26)10-4-3-5-24(7-10)12-6-11(16(17,18)19)13-14(20)21-8-22-25(12)13/h6,8-10H,3-5,7H2,1-2H3,(H,23,26)(H2,20,21,22)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284924
PNG
(1-(4-amino-5-(trifluoromethyl) pyrrolo[2,1-f][1,2,...)
Show SMILES Nc1ncnn2c(cc(c12)C(F)(F)F)N1CCCC(C1)C(=O)NC1CCCC1
Show InChI InChI=1S/C18H23F3N6O/c19-18(20,21)13-8-14(27-15(13)16(22)23-10-24-27)26-7-3-4-11(9-26)17(28)25-12-5-1-2-6-12/h8,10-12H,1-7,9H2,(H,25,28)(H2,22,23,24)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284922
PNG
(4-(4-amino-5-(trifluoromethyl) pyrrolo[2,1-f][1,2,...)
Show SMILES CC(C)NC(=O)C1CN(CCO1)c1cc(c2c(N)ncnn12)C(F)(F)F
Show InChI InChI=1S/C15H19F3N6O2/c1-8(2)22-14(25)10-6-23(3-4-26-10)11-5-9(15(16,17)18)12-13(19)20-7-21-24(11)12/h5,7-8,10H,3-4,6H2,1-2H3,(H,22,25)(H2,19,20,21)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM284925
PNG
(1-(4-amino-5-(trifluoromethyl) pyrrolo[2,1-f][1,2,...)
Show SMILES CN(C)C(=O)C1CCCN(C1)c1cc(c2c(N)ncnn12)C(F)(F)F
Show InChI InChI=1S/C15H19F3N6O/c1-22(2)14(25)9-4-3-5-23(7-9)11-6-10(15(16,17)18)12-13(19)20-8-21-24(11)12/h6,8-9H,3-5,7H2,1-2H3,(H2,19,20,21)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10023576 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%