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Patent code US10023583

Compile Data Set for Download or QSAR
Found 56 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM284944
PNG
(US10023583, Example 16)
Show SMILES N[C@@H](CCC1CC1)[C@](O)(Cc1nccc2oc(CCC3CC3)cc12)C(O)=O
Show InChI InChI=1S/C21H28N2O4/c22-19(8-6-14-3-4-14)21(26,20(24)25)12-17-16-11-15(7-5-13-1-2-13)27-18(16)9-10-23-17/h9-11,13-14,19,26H,1-8,12,22H2,(H,24,25)/t19-,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10023583 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM284942
PNG
(US10023583, Example 14)
Show SMILES N[C@@H](CCC1CCC1)[C@](O)(Cc1nccc2oc(CCC3CC3)cc12)C(O)=O
Show InChI InChI=1S/C22H30N2O4/c23-20(9-7-14-2-1-3-14)22(27,21(25)26)13-18-17-12-16(8-6-15-4-5-15)28-19(17)10-11-24-18/h10-12,14-15,20,27H,1-9,13,23H2,(H,25,26)/t20-,22+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10023583 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM284929
PNG
(US10023583, Example 2)
Show SMILES CSC[C@H](N)[C@](O)(Cc1nccc2oc(CCC3CC3)cc12)C(O)=O
Show InChI InChI=1S/C18H24N2O4S/c1-25-10-16(19)18(23,17(21)22)9-14-13-8-12(5-4-11-2-3-11)24-15(13)6-7-20-14/h6-8,11,16,23H,2-5,9-10,19H2,1H3,(H,21,22)/t16-,18+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10023583 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM284941
PNG
(US10023583, Example 13)
Show SMILES CCCSC[C@H](N)[C@](O)(Cc1nccc2oc(CCC3CC3)cc12)C(O)=O
Show InChI InChI=1S/C20H28N2O4S/c1-2-9-27-12-18(21)20(25,19(23)24)11-16-15-10-14(6-5-13-3-4-13)26-17(15)7-8-22-16/h7-8,10,13,18,25H,2-6,9,11-12,21H2,1H3,(H,23,24)/t18-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10023583 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM284943
PNG
(US10023583, Example 15)
Show SMILES N[C@@H](CCCC1CC1)[C@](O)(Cc1nccc2oc(CCC3CC3)cc12)C(O)=O
Show InChI InChI=1S/C22H30N2O4/c23-20(3-1-2-14-4-5-14)22(27,21(25)26)13-18-17-12-16(9-8-15-6-7-15)28-19(17)10-11-24-18/h10-12,14-15,20,27H,1-9,13,23H2,(H,25,26)/t20-,22+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10023583 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM284954
PNG
(US10023583, Example 26)
Show SMILES CCCCc1cc2c(C[C@@](O)([C@@H](N)CSC)C(O)=O)ncc(C)c2o1
Show InChI InChI=1S/C18H26N2O4S/c1-4-5-6-12-7-13-14(20-9-11(2)16(13)24-12)8-18(23,17(21)22)15(19)10-25-3/h7,9,15,23H,4-6,8,10,19H2,1-3H3,(H,21,22)/t15-,18+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10023583 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM284929
PNG
(US10023583, Example 2)
Show SMILES CSC[C@H](N)[C@](O)(Cc1nccc2oc(CCC3CC3)cc12)C(O)=O
Show InChI InChI=1S/C18H24N2O4S/c1-25-10-16(19)18(23,17(21)22)9-14-13-8-12(5-4-11-2-3-11)24-15(13)6-7-20-14/h6-8,11,16,23H,2-5,9-10,19H2,1H3,(H,21,22)/t16-,18+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10023583 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM284946
PNG
(US10023583, Example 18)
Show SMILES N[C@@H](COCCC1CC1)[C@](O)(Cc1nccc2oc(CCC3CC3)cc12)C(O)=O
Show InChI InChI=1S/C22H30N2O5/c23-20(13-28-10-8-15-3-4-15)22(27,21(25)26)12-18-17-11-16(6-5-14-1-2-14)29-19(17)7-9-24-18/h7,9,11,14-15,20,27H,1-6,8,10,12-13,23H2,(H,25,26)/t20-,22+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10023583 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM284930
PNG
(US10023583, Example 3)
Show SMILES CC(C)SC[C@H](N)[C@](O)(Cc1nccc2oc(CCC3CC3)cc12)C(O)=O
Show InChI InChI=1S/C20H28N2O4S/c1-12(2)27-11-18(21)20(25,19(23)24)10-16-15-9-14(6-5-13-3-4-13)26-17(15)7-8-22-16/h7-9,12-13,18,25H,3-6,10-11,21H2,1-2H3,(H,23,24)/t18-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10023583 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM284928
PNG
(US10023583, Example 1)
Show SMILES CCSC[C@H](N)[C@](O)(Cc1nccc2oc(CCC3CC3)cc12)C(O)=O
Show InChI InChI=1S/C19H26N2O4S/c1-2-26-11-17(20)19(24,18(22)23)10-15-14-9-13(6-5-12-3-4-12)25-16(14)7-8-21-15/h7-9,12,17,24H,2-6,10-11,20H2,1H3,(H,22,23)/t17-,19+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10023583 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM284954
PNG
(US10023583, Example 26)
Show SMILES CCCCc1cc2c(C[C@@](O)([C@@H](N)CSC)C(O)=O)ncc(C)c2o1
Show InChI InChI=1S/C18H26N2O4S/c1-4-5-6-12-7-13-14(20-9-11(2)16(13)24-12)8-18(23,17(21)22)15(19)10-25-3/h7,9,15,23H,4-6,8,10,19H2,1-3H3,(H,21,22)/t15-,18+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10023583 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM284928
PNG
(US10023583, Example 1)
Show SMILES CCSC[C@H](N)[C@](O)(Cc1nccc2oc(CCC3CC3)cc12)C(O)=O
Show InChI InChI=1S/C19H26N2O4S/c1-2-26-11-17(20)19(24,18(22)23)10-15-14-9-13(6-5-12-3-4-12)25-16(14)7-8-21-15/h7-9,12,17,24H,2-6,10-11,20H2,1H3,(H,22,23)/t17-,19+/m0/s1
PDB

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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10023583 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM284937
PNG
(US10023583, Example 9)
Show SMILES CSC[C@H](N)[C@](O)(Cc1nccc2oc(CCC(C)C)cc12)C(O)=O
Show InChI InChI=1S/C18H26N2O4S/c1-11(2)4-5-12-8-13-14(20-7-6-15(13)24-12)9-18(23,17(21)22)16(19)10-25-3/h6-8,11,16,23H,4-5,9-10,19H2,1-3H3,(H,21,22)/t16-,18+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10023583 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM284939
PNG
(US10023583, Example 11)
Show SMILES N[C@@H](CSCC1CCC1)[C@](O)(Cc1nccc2oc(CCC3CC3)cc12)C(O)=O
Show InChI InChI=1S/C22H30N2O4S/c23-20(13-29-12-15-2-1-3-15)22(27,21(25)26)11-18-17-10-16(7-6-14-4-5-14)28-19(17)8-9-24-18/h8-10,14-15,20,27H,1-7,11-13,23H2,(H,25,26)/t20-,22+/m0/s1
PDB

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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10023583 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM284955
PNG
(US10023583, Example 27)
Show SMILES CSC[C@H](N)[C@](O)(Cc1nccc2oc(cc12)C1CCCC1)C(O)=O
Show InChI InChI=1S/C18H24N2O4S/c1-25-10-16(19)18(23,17(21)22)9-13-12-8-15(11-4-2-3-5-11)24-14(12)6-7-20-13/h6-8,11,16,23H,2-5,9-10,19H2,1H3,(H,21,22)/t16-,18+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10023583 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM284942
PNG
(US10023583, Example 14)
Show SMILES N[C@@H](CCC1CCC1)[C@](O)(Cc1nccc2oc(CCC3CC3)cc12)C(O)=O
Show InChI InChI=1S/C22H30N2O4/c23-20(9-7-14-2-1-3-14)22(27,21(25)26)13-18-17-12-16(8-6-15-4-5-15)28-19(17)10-11-24-18/h10-12,14-15,20,27H,1-9,13,23H2,(H,25,26)/t20-,22+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10023583 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM284937
PNG
(US10023583, Example 9)
Show SMILES CSC[C@H](N)[C@](O)(Cc1nccc2oc(CCC(C)C)cc12)C(O)=O
Show InChI InChI=1S/C18H26N2O4S/c1-11(2)4-5-12-8-13-14(20-7-6-15(13)24-12)9-18(23,17(21)22)16(19)10-25-3/h6-8,11,16,23H,4-5,9-10,19H2,1-3H3,(H,21,22)/t16-,18+/m0/s1
PDB

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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10023583 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM284955
PNG
(US10023583, Example 27)
Show SMILES CSC[C@H](N)[C@](O)(Cc1nccc2oc(cc12)C1CCCC1)C(O)=O
Show InChI InChI=1S/C18H24N2O4S/c1-25-10-16(19)18(23,17(21)22)9-13-12-8-15(11-4-2-3-5-11)24-14(12)6-7-20-13/h6-8,11,16,23H,2-5,9-10,19H2,1H3,(H,21,22)/t16-,18+/m0/s1
PDB

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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10023583 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM284941
PNG
(US10023583, Example 13)
Show SMILES CCCSC[C@H](N)[C@](O)(Cc1nccc2oc(CCC3CC3)cc12)C(O)=O
Show InChI InChI=1S/C20H28N2O4S/c1-2-9-27-12-18(21)20(25,19(23)24)11-16-15-10-14(6-5-13-3-4-13)26-17(15)7-8-22-16/h7-8,10,13,18,25H,2-6,9,11-12,21H2,1H3,(H,23,24)/t18-,20+/m0/s1
PDB

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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10023583 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM284945
PNG
(US10023583, Example 17)
Show SMILES N[C@@H](COCC1CC1)[C@](O)(Cc1nccc2oc(CCC3CC3)cc12)C(O)=O
Show InChI InChI=1S/C21H28N2O5/c22-19(12-27-11-14-3-4-14)21(26,20(24)25)10-17-16-9-15(6-5-13-1-2-13)28-18(16)7-8-23-17/h7-9,13-14,19,26H,1-6,10-12,22H2,(H,24,25)/t19-,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10023583 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM284953
PNG
(US10023583, Example 25)
Show SMILES N[C@@H](CSCC1CC1)[C@](O)(Cc1nccc2oc(CCC3CC3)cc12)C(O)=O
Show InChI InChI=1S/C21H28N2O4S/c22-19(12-28-11-14-3-4-14)21(26,20(24)25)10-17-16-9-15(6-5-13-1-2-13)27-18(16)7-8-23-17/h7-9,13-14,19,26H,1-6,10-12,22H2,(H,24,25)/t19-,21+/m0/s1
PDB

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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10023583 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM284951
PNG
(US10023583, Example 23)
Show SMILES N[C@@H](CSCCC1CC1)[C@](O)(Cc1nccc2oc(CCC3CC3)cc12)C(O)=O
Show InChI InChI=1S/C22H30N2O4S/c23-20(13-29-10-8-15-3-4-15)22(27,21(25)26)12-18-17-11-16(6-5-14-1-2-14)28-19(17)7-9-24-18/h7,9,11,14-15,20,27H,1-6,8,10,12-13,23H2,(H,25,26)/t20-,22+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10023583 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM284951
PNG
(US10023583, Example 23)
Show SMILES N[C@@H](CSCCC1CC1)[C@](O)(Cc1nccc2oc(CCC3CC3)cc12)C(O)=O
Show InChI InChI=1S/C22H30N2O4S/c23-20(13-29-10-8-15-3-4-15)22(27,21(25)26)12-18-17-11-16(6-5-14-1-2-14)28-19(17)7-9-24-18/h7,9,11,14-15,20,27H,1-6,8,10,12-13,23H2,(H,25,26)/t20-,22+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10023583 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM284940
PNG
(US10023583, Example 12)
Show SMILES N[C@@H](CSC1CCC1)[C@](O)(Cc1nccc2oc(CCC3CC3)cc12)C(O)=O
Show InChI InChI=1S/C21H28N2O4S/c22-19(12-28-15-2-1-3-15)21(26,20(24)25)11-17-16-10-14(7-6-13-4-5-13)27-18(16)8-9-23-17/h8-10,13,15,19,26H,1-7,11-12,22H2,(H,24,25)/t19-,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10023583 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM284943
PNG
(US10023583, Example 15)
Show SMILES N[C@@H](CCCC1CC1)[C@](O)(Cc1nccc2oc(CCC3CC3)cc12)C(O)=O
Show InChI InChI=1S/C22H30N2O4/c23-20(3-1-2-14-4-5-14)22(27,21(25)26)13-18-17-12-16(9-8-15-6-7-15)28-19(17)10-11-24-18/h10-12,14-15,20,27H,1-9,13,23H2,(H,25,26)/t20-,22+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10023583 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM284949
PNG
(US10023583, Example 21)
Show SMILES CSC[C@H](N)[C@](O)(Cc1nccc2OC(CCC3CC3)Cc12)C(O)=O
Show InChI InChI=1S/C18H26N2O4S/c1-25-10-16(19)18(23,17(21)22)9-14-13-8-12(5-4-11-2-3-11)24-15(13)6-7-20-14/h6-7,11-12,16,23H,2-5,8-10,19H2,1H3,(H,21,22)/t12?,16-,18+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10023583 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM284944
PNG
(US10023583, Example 16)
Show SMILES N[C@@H](CCC1CC1)[C@](O)(Cc1nccc2oc(CCC3CC3)cc12)C(O)=O
Show InChI InChI=1S/C21H28N2O4/c22-19(8-6-14-3-4-14)21(26,20(24)25)12-17-16-11-15(7-5-13-1-2-13)27-18(16)9-10-23-17/h9-11,13-14,19,26H,1-8,12,22H2,(H,24,25)/t19-,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10023583 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM284949
PNG
(US10023583, Example 21)
Show SMILES CSC[C@H](N)[C@](O)(Cc1nccc2OC(CCC3CC3)Cc12)C(O)=O
Show InChI InChI=1S/C18H26N2O4S/c1-25-10-16(19)18(23,17(21)22)9-14-13-8-12(5-4-11-2-3-11)24-15(13)6-7-20-14/h6-7,11-12,16,23H,2-5,8-10,19H2,1H3,(H,21,22)/t12?,16-,18+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10023583 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM284936
PNG
(US10023583, Example 8)
Show SMILES CCCCc1cc2c(C[C@@](O)([C@@H](N)CSC)C(O)=O)nccc2s1
Show InChI InChI=1S/C17H24N2O3S2/c1-3-4-5-11-8-12-13(19-7-6-14(12)24-11)9-17(22,16(20)21)15(18)10-23-2/h6-8,15,22H,3-5,9-10,18H2,1-2H3,(H,20,21)/t15-,17+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10023583 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM284935
PNG
(US10023583, Example 7(2))
Show SMILES CCC(Cl)CCc1cc2c(C[C@@](O)([C@@H](N)CSC)C(O)=O)nccc2o1
Show InChI InChI=1S/C18H25ClN2O4S/c1-3-11(19)4-5-12-8-13-14(21-7-6-15(13)25-12)9-18(24,17(22)23)16(20)10-26-2/h6-8,11,16,24H,3-5,9-10,20H2,1-2H3,(H,22,23)/t11?,16-,18+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10023583 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM284953
PNG
(US10023583, Example 25)
Show SMILES N[C@@H](CSCC1CC1)[C@](O)(Cc1nccc2oc(CCC3CC3)cc12)C(O)=O
Show InChI InChI=1S/C21H28N2O4S/c22-19(12-28-11-14-3-4-14)21(26,20(24)25)10-17-16-9-15(6-5-13-1-2-13)27-18(16)7-8-23-17/h7-9,13-14,19,26H,1-6,10-12,22H2,(H,24,25)/t19-,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10023583 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM284952
PNG
(US10023583, Example 24)
Show SMILES CC(C)CSC[C@H](N)[C@](O)(Cc1nccc2oc(CCC3CC3)cc12)C(O)=O
Show InChI InChI=1S/C21H30N2O4S/c1-13(2)11-28-12-19(22)21(26,20(24)25)10-17-16-9-15(6-5-14-3-4-14)27-18(16)7-8-23-17/h7-9,13-14,19,26H,3-6,10-12,22H2,1-2H3,(H,24,25)/t19-,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10023583 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM284946
PNG
(US10023583, Example 18)
Show SMILES N[C@@H](COCCC1CC1)[C@](O)(Cc1nccc2oc(CCC3CC3)cc12)C(O)=O
Show InChI InChI=1S/C22H30N2O5/c23-20(13-28-10-8-15-3-4-15)22(27,21(25)26)12-18-17-11-16(6-5-14-1-2-14)29-19(17)7-9-24-18/h7,9,11,14-15,20,27H,1-6,8,10,12-13,23H2,(H,25,26)/t20-,22+/m0/s1
PDB

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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10023583 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM284940
PNG
(US10023583, Example 12)
Show SMILES N[C@@H](CSC1CCC1)[C@](O)(Cc1nccc2oc(CCC3CC3)cc12)C(O)=O
Show InChI InChI=1S/C21H28N2O4S/c22-19(12-28-15-2-1-3-15)21(26,20(24)25)11-17-16-10-14(7-6-13-4-5-13)27-18(16)8-9-23-17/h8-10,13,15,19,26H,1-7,11-12,22H2,(H,24,25)/t19-,21+/m0/s1
PDB

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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10023583 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM284935
PNG
(US10023583, Example 7(2))
Show SMILES CCC(Cl)CCc1cc2c(C[C@@](O)([C@@H](N)CSC)C(O)=O)nccc2o1
Show InChI InChI=1S/C18H25ClN2O4S/c1-3-11(19)4-5-12-8-13-14(21-7-6-15(13)25-12)9-18(24,17(22)23)16(20)10-26-2/h6-8,11,16,24H,3-5,9-10,20H2,1-2H3,(H,22,23)/t11?,16-,18+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10023583 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM284936
PNG
(US10023583, Example 8)
Show SMILES CCCCc1cc2c(C[C@@](O)([C@@H](N)CSC)C(O)=O)nccc2s1
Show InChI InChI=1S/C17H24N2O3S2/c1-3-4-5-11-8-12-13(19-7-6-14(12)24-11)9-17(22,16(20)21)15(18)10-23-2/h6-8,15,22H,3-5,9-10,18H2,1-2H3,(H,20,21)/t15-,17+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10023583 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM284939
PNG
(US10023583, Example 11)
Show SMILES N[C@@H](CSCC1CCC1)[C@](O)(Cc1nccc2oc(CCC3CC3)cc12)C(O)=O
Show InChI InChI=1S/C22H30N2O4S/c23-20(13-29-12-15-2-1-3-15)22(27,21(25)26)11-18-17-10-16(7-6-14-4-5-14)28-19(17)8-9-24-18/h8-10,14-15,20,27H,1-7,11-13,23H2,(H,25,26)/t20-,22+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10023583 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM284945
PNG
(US10023583, Example 17)
Show SMILES N[C@@H](COCC1CC1)[C@](O)(Cc1nccc2oc(CCC3CC3)cc12)C(O)=O
Show InChI InChI=1S/C21H28N2O5/c22-19(12-27-11-14-3-4-14)21(26,20(24)25)10-17-16-9-15(6-5-13-1-2-13)28-18(16)7-8-23-17/h7-9,13-14,19,26H,1-6,10-12,22H2,(H,24,25)/t19-,21+/m0/s1
PDB

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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10023583 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM284952
PNG
(US10023583, Example 24)
Show SMILES CC(C)CSC[C@H](N)[C@](O)(Cc1nccc2oc(CCC3CC3)cc12)C(O)=O
Show InChI InChI=1S/C21H30N2O4S/c1-13(2)11-28-12-19(22)21(26,20(24)25)10-17-16-9-15(6-5-14-3-4-14)27-18(16)7-8-23-17/h7-9,13-14,19,26H,3-6,10-12,22H2,1-2H3,(H,24,25)/t19-,21+/m0/s1
PDB

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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10023583 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM284930
PNG
(US10023583, Example 3)
Show SMILES CC(C)SC[C@H](N)[C@](O)(Cc1nccc2oc(CCC3CC3)cc12)C(O)=O
Show InChI InChI=1S/C20H28N2O4S/c1-12(2)27-11-18(21)20(25,19(23)24)10-16-15-9-14(6-5-13-3-4-13)26-17(15)7-8-22-16/h7-9,12-13,18,25H,3-6,10-11,21H2,1-2H3,(H,23,24)/t18-,20+/m0/s1
PDB

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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10023583 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM284950
PNG
(US10023583, Example 22)
Show SMILES CSC[C@@H](N)[C@](O)(Cc1nccc2oc(CCC3CC3)cc12)C(O)=O
Show InChI InChI=1S/C18H24N2O4S/c1-25-10-16(19)18(23,17(21)22)9-14-13-8-12(5-4-11-2-3-11)24-15(13)6-7-20-14/h6-8,11,16,23H,2-5,9-10,19H2,1H3,(H,21,22)/t16-,18-/m1/s1
PDB

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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10023583 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM284933
PNG
(US10023583, Example 6)
Show SMILES CSC[C@H](N)[C@](O)(Cc1nccc2oc(CCC3CC3)cc12)C(N)=O
Show InChI InChI=1S/C18H25N3O3S/c1-25-10-16(19)18(23,17(20)22)9-14-13-8-12(5-4-11-2-3-11)24-15(13)6-7-21-14/h6-8,11,16,23H,2-5,9-10,19H2,1H3,(H2,20,22)/t16-,18+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10023583 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM284933
PNG
(US10023583, Example 6)
Show SMILES CSC[C@H](N)[C@](O)(Cc1nccc2oc(CCC3CC3)cc12)C(N)=O
Show InChI InChI=1S/C18H25N3O3S/c1-25-10-16(19)18(23,17(20)22)9-14-13-8-12(5-4-11-2-3-11)24-15(13)6-7-21-14/h6-8,11,16,23H,2-5,9-10,19H2,1H3,(H2,20,22)/t16-,18+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10023583 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM284934
PNG
(US10023583, Example 7(1))
Show SMILES CCC(O)CCc1cc2c(C[C@@](O)([C@@H](N)CSC)C(O)=O)nccc2o1
Show InChI InChI=1S/C18H26N2O5S/c1-3-11(21)4-5-12-8-13-14(20-7-6-15(13)25-12)9-18(24,17(22)23)16(19)10-26-2/h6-8,11,16,21,24H,3-5,9-10,19H2,1-2H3,(H,22,23)/t11?,16-,18+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10023583 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM284950
PNG
(US10023583, Example 22)
Show SMILES CSC[C@@H](N)[C@](O)(Cc1nccc2oc(CCC3CC3)cc12)C(O)=O
Show InChI InChI=1S/C18H24N2O4S/c1-25-10-16(19)18(23,17(21)22)9-14-13-8-12(5-4-11-2-3-11)24-15(13)6-7-20-14/h6-8,11,16,23H,2-5,9-10,19H2,1H3,(H,21,22)/t16-,18-/m1/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10023583 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM284934
PNG
(US10023583, Example 7(1))
Show SMILES CCC(O)CCc1cc2c(C[C@@](O)([C@@H](N)CSC)C(O)=O)nccc2o1
Show InChI InChI=1S/C18H26N2O5S/c1-3-11(21)4-5-12-8-13-14(20-7-6-15(13)25-12)9-18(24,17(22)23)16(19)10-26-2/h6-8,11,16,21,24H,3-5,9-10,19H2,1-2H3,(H,22,23)/t11?,16-,18+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10023583 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM284932
PNG
(US10023583, Example 5)
Show SMILES COC(=O)[C@@](O)(Cc1nccc2oc(CCC3CC3)cc12)[C@@H](N)CSC
Show InChI InChI=1S/C19H26N2O4S/c1-24-18(22)19(23,17(20)11-26-2)10-15-14-9-13(6-5-12-3-4-12)25-16(14)7-8-21-15/h7-9,12,17,23H,3-6,10-11,20H2,1-2H3/t17-,19+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10023583 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM284938
PNG
(US10023583, Example 10)
Show SMILES CCSC[C@H](N)[C@](O)(Cc1nccc2oc(CC)c(CC)c12)C(O)=O
Show InChI InChI=1S/C18H26N2O4S/c1-4-11-13(5-2)24-14-7-8-20-12(16(11)14)9-18(23,17(21)22)15(19)10-25-6-3/h7-8,15,23H,4-6,9-10,19H2,1-3H3,(H,21,22)/t15-,18+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10023583 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM284938
PNG
(US10023583, Example 10)
Show SMILES CCSC[C@H](N)[C@](O)(Cc1nccc2oc(CC)c(CC)c12)C(O)=O
Show InChI InChI=1S/C18H26N2O4S/c1-4-11-13(5-2)24-14-7-8-20-12(16(11)14)9-18(23,17(21)22)15(19)10-25-6-3/h7-8,15,23H,4-6,9-10,19H2,1-3H3,(H,21,22)/t15-,18+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10023583 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM284932
PNG
(US10023583, Example 5)
Show SMILES COC(=O)[C@@](O)(Cc1nccc2oc(CCC3CC3)cc12)[C@@H](N)CSC
Show InChI InChI=1S/C19H26N2O4S/c1-24-18(22)19(23,17(20)11-26-2)10-15-14-9-13(6-5-12-3-4-12)25-16(14)7-8-21-15/h7-9,12,17,23H,3-6,10-11,20H2,1-2H3/t17-,19+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10023583 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM284947
PNG
(US10023583, Example 19)
Show SMILES CS(=O)(=O)C[C@H](N)[C@](O)(Cc1nccc2oc(CCC3CC3)cc12)C(O)=O
Show InChI InChI=1S/C18H24N2O6S/c1-27(24,25)10-16(19)18(23,17(21)22)9-14-13-8-12(5-4-11-2-3-11)26-15(13)6-7-20-14/h6-8,11,16,23H,2-5,9-10,19H2,1H3,(H,21,22)/t16-,18+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10023583 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM284948
PNG
(US10023583, Example 20)
Show SMILES CS(=O)C[C@H](N)[C@](O)(Cc1nccc2oc(CCC3CC3)cc12)C(O)=O
Show InChI InChI=1S/C18H24N2O5S/c1-26(24)10-16(19)18(23,17(21)22)9-14-13-8-12(5-4-11-2-3-11)25-15(13)6-7-20-14/h6-8,11,16,23H,2-5,9-10,19H2,1H3,(H,21,22)/t16-,18+,26?/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10023583 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM284948
PNG
(US10023583, Example 20)
Show SMILES CS(=O)C[C@H](N)[C@](O)(Cc1nccc2oc(CCC3CC3)cc12)C(O)=O
Show InChI InChI=1S/C18H24N2O5S/c1-26(24)10-16(19)18(23,17(21)22)9-14-13-8-12(5-4-11-2-3-11)25-15(13)6-7-20-14/h6-8,11,16,23H,2-5,9-10,19H2,1H3,(H,21,22)/t16-,18+,26?/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10023583 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM284947
PNG
(US10023583, Example 19)
Show SMILES CS(=O)(=O)C[C@H](N)[C@](O)(Cc1nccc2oc(CCC3CC3)cc12)C(O)=O
Show InChI InChI=1S/C18H24N2O6S/c1-27(24,25)10-16(19)18(23,17(21)22)9-14-13-8-12(5-4-11-2-3-11)26-15(13)6-7-20-14/h6-8,11,16,23H,2-5,9-10,19H2,1H3,(H,21,22)/t16-,18+/m0/s1
PDB

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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10023583 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM284931
PNG
(US10023583, Example 4)
Show SMILES CSC[C@H](N)[C@@]1(Cc2nccc3oc(CCC4CC4)cc23)OC(C)(C)OC1=O
Show InChI InChI=1S/C21H28N2O4S/c1-20(2)26-19(24)21(27-20,18(22)12-28-3)11-16-15-10-14(7-6-13-4-5-13)25-17(15)8-9-23-16/h8-10,13,18H,4-7,11-12,22H2,1-3H3/t18-,21+/m0/s1
PDB

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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10023583 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM284931
PNG
(US10023583, Example 4)
Show SMILES CSC[C@H](N)[C@@]1(Cc2nccc3oc(CCC4CC4)cc23)OC(C)(C)OC1=O
Show InChI InChI=1S/C21H28N2O4S/c1-20(2)26-19(24)21(27-20,18(22)12-28-3)11-16-15-10-14(7-6-13-4-5-13)25-17(15)8-9-23-16/h8-10,13,18H,4-7,11-12,22H2,1-3H3/t18-,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10023583 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%