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Found 100 Enz. Inhib. hit(s) with all data for entry = 590
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM280371(US10030012, Example 1 | ethyl 4-[4- (1-methyl- 1H-...)
Affinity DataEC50:  2.36E+3nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM280371(US10030012, Example 1 | ethyl 4-[4- (1-methyl- 1H-...)
Affinity DataEC50: >1.00E+7nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM280372(US10030012, Example 2 | ethyl 4-(4-{1- [(cyclohexy...)
Affinity DataEC50:  1.87E+3nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM280373(US10030012, Example 3 | ethyl 4-[4-(1H- pyrrol-1- ...)
Affinity DataEC50:  330nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM280373(US10030012, Example 3 | ethyl 4-[4-(1H- pyrrol-1- ...)
Affinity DataEC50:  1.54E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM280374(US10030012, Example 4 | ethyl 4-[4-(1H- pyrazol-1-...)
Affinity DataEC50:  140nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM280375(US10030012, Example 5 | ethyl 4-{4-[5-(4- chloroph...)
Affinity DataEC50:  250nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM280375(US10030012, Example 5 | ethyl 4-{4-[5-(4- chloroph...)
Affinity DataEC50: >1.00E+7nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM280376(US10030012, Example 6 | ethyl 4-[4-(1H- pyrazol-3-...)
Affinity DataEC50:  190nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM280377(US10030012, Example 7 | ethyl 4-{4-[5-(1- methyl-1...)
Affinity DataEC50:  260nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM280377(US10030012, Example 7 | ethyl 4-{4-[5-(1- methyl-1...)
Affinity DataEC50: >1.00E+7nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM280378(US10030012, Example 8 | ethyl 4-{4-[4-(4- chloroph...)
Affinity DataEC50:  320nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM280379(US10030012, Example 9 | ethyl 4-[4-(1- methyl-1H- ...)
Affinity DataEC50:  1.05E+3nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM280380(US10030012, Example 10 | ethyl 4-[4- (1-ethyl- 1H-...)
Affinity DataEC50:  1.74E+3nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM280381(US10030012, Example 11 | ethyl 4-[4-(1- propyl-1H-...)
Affinity DataEC50:  960nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM280382(US10030012, Example 12 | ethyl 4-[4-(5- methyl-1H-...)
Affinity DataEC50:  520nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM280382(US10030012, Example 12 | ethyl 4-[4-(5- methyl-1H-...)
Affinity DataEC50: >1.00E+7nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM280383(US10030012, Example 13 | ethyl 4-[4- methoxy-4- (1...)
Affinity DataEC50:  2.88E+3nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM280384(US10030012, Example 14 | ethyl 4-[4-(1- methyl-1H-...)
Affinity DataEC50:  750nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM280385(US10030012, Example 15 | ethyl 4-(4-(5- isopropyl-...)
Affinity DataEC50:  1.28E+3nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM280386(US10030012, Example 16 | ethyl 4-[4- (3-methyl- 1H...)
Affinity DataEC50:  400nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM280386(US10030012, Example 16 | ethyl 4-[4- (3-methyl- 1H...)
Affinity DataEC50: >1.00E+7nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM280387(US10030012, Example 17 | ethyl 4-{4-[3- (thiophen-...)
Affinity DataEC50:  810nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM280388(US10030012, Example 18 | ethyl 4-{4-[4-(4- fluorop...)
Affinity DataEC50:  410nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM280389(US10030012, Example 19 | ethyl 4-(4-{1- [(cyclopro...)
Affinity DataEC50:  1.51E+3nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM280390(US10030012, Example 20 | ethyl 4-[4-(5- cyclopropy...)
Affinity DataEC50:  190nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM280390(US10030012, Example 20 | ethyl 4-[4-(5- cyclopropy...)
Affinity DataEC50:  2.26E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM280391(US10030012, Example 21 | ethyl 4-{4-[5- (dimethyl-...)
Affinity DataEC50:  2.68E+3nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM280392(US10030012, Example 22 | ethyl 4-(4-{5- [1-(propan...)
Affinity DataEC50:  200nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM280392(US10030012, Example 22 | ethyl 4-(4-{5- [1-(propan...)
Affinity DataEC50:  680nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM280393(US10030012, Example 23 | ethyl 4-{4-[5- (methoxy- ...)
Affinity DataEC50:  750nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM280394(US10030012, Example 24 | ethyl 4-(4-{5- [(cyclopro...)
Affinity DataEC50:  1.37E+3nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM280395(US10030012, Example 25 | ethyl 4-{4-[5- (dimethyl-...)
Affinity DataEC50:  270nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM280396(US10030012, Example 26 | ethyl 4-[4-(1,3- thiazol-...)
Affinity DataEC50:  130nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM280397(US10030012, Example 27 | ethyl 4-[4-(5- cyano-1H- ...)
Affinity DataEC50:  320nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM280398(US10030012, Example 28 | ethyl 4-{4-[5- (acetamido...)
Affinity DataEC50:  1.48E+3nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM280399(US10030012, Example 29 | ethyl 4-{[3- (1H-pyrazol-...)
Affinity DataEC50:  1.83E+3nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM280400(US10030012, Example 30 | ethyl 4- [4-(pyridin- 4-y...)
Affinity DataEC50:  1.66E+3nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM280401(US10030012, Example 31 | ethyl 4- [4-(pyridin-4- y...)
Affinity DataEC50:  2.26E+3nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM280402(US10030012, Example 32 | ethyl 4-[4-(6- methoxypyr...)
Affinity DataEC50:  220nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM280403(US10030012, Example 33 | ethyl 4-[4-(6- methoxypyr...)
Affinity DataEC50:  180nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM280404(US10030012, Example 34 | ethyl 4-[4-(2- methoxypyr...)
Affinity DataEC50:  90nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM280405(US10030012, Example 35 | ethyl 4-[4-(2- methoxypyr...)
Affinity DataEC50:  30nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM280406(US10030012, Example 36 | ethyl 4-[4-(2- methylpyri...)
Affinity DataEC50:  6.73E+3nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM280407(US10030012, Example 37 | ethyl 4-[4-(4,6- dimethox...)
Affinity DataEC50:  3.34E+3nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM280408(US10030012, Example 38 | ethyl 4-[4-(3- methoxypyr...)
Affinity DataEC50:  30nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM280408(US10030012, Example 38 | ethyl 4-[4-(3- methoxypyr...)
Affinity DataEC50:  160nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM280409(US10030012, Example 39 | ethyl 4-[4-(1- methyl-2-o...)
Affinity DataEC50:  740nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM280410(US10030012, Example 40 | ethyl 4-[4-(3- methoxypyr...)
Affinity DataEC50:  140nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM280411(US10030012, Example 41 | ethyl 4-[4-(2- methylpyri...)
Affinity DataEC50:  260nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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