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Patent code US10030016

Compile Data Set for Download or QSAR

Found 798 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM282382
PNG
(2-(4-(3-amino-1H-pyrazolo [3,4-b]pyridin-5-yl) ben...)
Show SMILES Nc1n[nH]c2ncc(cc12)-c1ccc(CNc2ncc(cc2C(=O)Nc2cccc(F)c2)C(F)(F)F)cc1
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n/an/a<100n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM282383
PNG
(2-(4-(3-amino-1H-pyrazolo [3,4-b]pyridin-5-yl) ben...)
Show SMILES Nc1n[nH]c2ncc(cc12)-c1ccc(CNc2ncc(cc2C(=O)Nc2ccc(F)c(F)c2)C(F)(F)F)cc1
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UniChem
n/an/a<100n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM282396
PNG
(2-(4-(3-amino-1H-pyrazolo [3,4-b]pyridin-5-yl) ben...)
Show SMILES Nc1n[nH]c2ncc(cc12)-c1ccc(CNc2ncc(cc2C(=O)Nc2ccc(nc2)C(F)(F)F)C(F)(F)F)cc1
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UniChem
n/an/a<100n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM282436
PNG
((S)-3-(4-(4-amino-7- (3-(dimethylamino) propyl)-7H...)
Show SMILES C[C@H](NC(=O)c1nc(cnc1NCc1ccc(cc1)-c1cn(CCCN(C)C)c2ncnc(N)c12)C#N)c1ccc(F)c(F)c1
Show InChI InChI=1S/C32H32F2N10O/c1-19(22-9-10-25(33)26(34)13-22)41-32(45)28-30(38-16-23(14-35)42-28)37-15-20-5-7-21(8-6-20)24-17-44(12-4-11-43(2)3)31-27(24)29(36)39-18-40-31/h5-10,13,16-19H,4,11-12,15H2,1-3H3,(H,37,38)(H,41,45)(H2,36,39,40)/t19-/m0/s1
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n/an/a<100n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM282442
PNG
(2-(4-(4-amino-7-(3- hydroxypropyl)-7H-pyrrolo [2,3...)
Show SMILES Nc1ncnc2n(CCCO)cc(-c3ccc(CNc4ncc(cc4C(=O)Nc4ccc(F)cc4)C(F)(F)F)cc3)c12
Show InChI InChI=1S/C29H25F4N7O2/c30-20-6-8-21(9-7-20)39-28(42)22-12-19(29(31,32)33)14-36-26(22)35-13-17-2-4-18(5-3-17)23-15-40(10-1-11-41)27-24(23)25(34)37-16-38-27/h2-9,12,14-16,41H,1,10-11,13H2,(H,35,36)(H,39,42)(H2,34,37,38)
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n/an/a<100n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM281813
PNG
(2-(4-(1H-pyrazolo[3,4-b]pyridin- 5-yl)benzylamino)...)
Show SMILES Fc1ccc(CNC(=O)c2cccnc2NCc2ccc(cc2)-c2cnc3[nH]ncc3c2)cc1F
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n/an/a<100n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM282483
PNG
((S)-6-cyano-N-(1-(3,4- difluorophenyl)ethyl)- 3-(4...)
Show SMILES C[C@H](NC(=O)c1nc(cnc1NCc1ccc(cc1)-c1cnc2[nH]c(=O)[nH]c2c1)C#N)c1ccc(F)c(F)c1
Show InChI InChI=1S/C27H18F2N8O2/c1-14(17-6-7-20(28)21(29)8-17)34-26(38)23-25(33-13-19(10-30)35-23)31-11-15-2-4-16(5-3-15)18-9-22-24(32-12-18)37-27(39)36-22/h2-9,12-14H,11H2,1H3,(H,31,33)(H,34,38)/t14-/m0/s1
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n/an/a<100n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM282507
PNG
(2-{[5-(4-Azetidin-1-yl- quinazolin- 6-yl)-thiophen...)
Show SMILES C[C@H](NC(=O)c1cccnc1NCc1ccc(s1)-c1ccc2ncnc(N3CCC3)c2c1)c1ccc(F)c(F)c1
Show InChI InChI=1S/C30H26F2N6OS/c1-18(19-5-8-24(31)25(32)15-19)37-30(39)22-4-2-11-33-28(22)34-16-21-7-10-27(40-21)20-6-9-26-23(14-20)29(36-17-35-26)38-12-3-13-38/h2,4-11,14-15,17-18H,3,12-13,16H2,1H3,(H,33,34)(H,37,39)/t18-/m0/s1
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n/an/a<100n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM282510
PNG
(6-Cyano-3-[4-(1H-pyrazolo [3,4-b]pyridin-5-yl)- be...)
Show SMILES C[C@H](NC(=O)c1nc(cnc1NCc1ccc(cc1)-c1cnc2[nH]ncc2c1)C#N)c1ccc(F)c(F)c1
GoogleScholar
AffyNet 
UniChem
n/an/a<100n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM282516
PNG
(5-Cyano-N-(3,4-difluoro- benzyl)-2-[4-(1H- pyrazol...)
Show SMILES Fc1ccc(CNC(=O)c2cc(cnc2NCc2ccc(cc2)-c2cnc3[nH]ncc3c2)C#N)cc1F
GoogleScholar
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UniChem
n/an/a<100n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM282521
PNG
((S)-3-(4-(8-amino-3-methyl- imidazo[1,5-a]pyrazin-...)
Show SMILES C[C@H](NC(=O)c1nc(cnc1NCc1ccc(cc1)C1=C2N(C=CN=C2N)[N](C)=C1)C#N)c1ccc(F)c(F)c1
Show InChI InChI=1S/C28H24F2N9O/c1-16(19-7-8-22(29)23(30)11-19)36-28(40)24-27(35-14-20(12-31)37-24)34-13-17-3-5-18(6-4-17)21-15-38(2)39-10-9-33-26(32)25(21)39/h3-11,14-16H,13H2,1-2H3,(H2,32,33)(H,34,35)(H,36,40)/t16-/m0/s1
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n/an/a<100n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM282528
PNG
(2-[4-(3-Amino-1H-pyrazolo [3,4-b]pyridin-5-yl)-3- ...)
Show SMILES C[C@H](NC(=O)c1cc(cnc1NCc1ccc(c(C)c1)-c1cnc2[nH]nc(N)c2c1)C#N)c1ccc(F)cc1
GoogleScholar
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UniChem
n/an/a<100n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM282531
PNG
(3-{(R)-1-[4-(3-Amino-1H- pyrazolo[3,4-b]pyrazin- 5...)
Show SMILES C[C@H](NC(=O)c1nc(cnc1N[C@H](C)c1ccc(cc1)-c1cnc2[nH]nc(N)c2n1)C#N)c1ccc(F)c(F)c1
GoogleScholar
AffyNet 
UniChem
n/an/a<100n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM282539
PNG
(2-(4-(3-amino-1H-pyrazolo [3,4-b]pyridin-5-yl) ben...)
Show SMILES Nc1n[nH]c2ncc(cc12)-c1ccc(CNc2ncc(cc2C(=O)NCc2ccc(Cl)c(F)c2)C(F)(F)F)cc1
GoogleScholar
AffyNet 
UniChem
n/an/a<100n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM282549
PNG
(2-(4-(4-amino-7-propyl- 7H-pyrrolo[2,3-d]pyrimidin...)
Show SMILES CCCn1cc(-c2ccc(CNc3ncc(cc3C(=O)Nc3ccc(F)cc3)C(F)(F)F)cc2)c2c(N)ncnc12
Show InChI InChI=1S/C29H25F4N7O/c1-2-11-40-15-23(24-25(34)37-16-38-27(24)40)18-5-3-17(4-6-18)13-35-26-22(12-19(14-36-26)29(31,32)33)28(41)39-21-9-7-20(30)8-10-21/h3-10,12,14-16H,2,11,13H2,1H3,(H,35,36)(H,39,41)(H2,34,37,38)
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UniChem
n/an/a<100n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM281916
PNG
(US10030016, Example 4.1.17 | US10030016, Example 4...)
Show SMILES CCOC(=O)c1cccnc1NCc1cc(OC(C)C)cc(c1)-c1cn(c2ncc(cc12)C(=O)NC1CC1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C35H35N5O6S/c1-4-45-35(42)29-11-8-14-36-32(29)37-19-23-15-24(17-27(16-23)46-22(2)3)31-21-40(47(43,44)28-9-6-5-7-10-28)33-30(31)18-25(20-38-33)34(41)39-26-12-13-26/h5-11,14-18,20-22,26H,4,12-13,19H2,1-3H3,(H,36,37)(H,39,41)
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UniChem
n/an/a<100n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM281916
PNG
(US10030016, Example 4.1.17 | US10030016, Example 4...)
Show SMILES CCOC(=O)c1cccnc1NCc1cc(OC(C)C)cc(c1)-c1cn(c2ncc(cc12)C(=O)NC1CC1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C35H35N5O6S/c1-4-45-35(42)29-11-8-14-36-32(29)37-19-23-15-24(17-27(16-23)46-22(2)3)31-21-40(47(43,44)28-9-6-5-7-10-28)33-30(31)18-25(20-38-33)34(41)39-26-12-13-26/h5-11,14-18,20-22,26H,4,12-13,19H2,1-3H3,(H,36,37)(H,39,41)
GoogleScholar
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UniChem
n/an/a<100n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM281916
PNG
(US10030016, Example 4.1.17 | US10030016, Example 4...)
Show SMILES CCOC(=O)c1cccnc1NCc1cc(OC(C)C)cc(c1)-c1cn(c2ncc(cc12)C(=O)NC1CC1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C35H35N5O6S/c1-4-45-35(42)29-11-8-14-36-32(29)37-19-23-15-24(17-27(16-23)46-22(2)3)31-21-40(47(43,44)28-9-6-5-7-10-28)33-30(31)18-25(20-38-33)34(41)39-26-12-13-26/h5-11,14-18,20-22,26H,4,12-13,19H2,1-3H3,(H,36,37)(H,39,41)
GoogleScholar
AffyNet 
UniChem
n/an/a<100n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM281916
PNG
(US10030016, Example 4.1.17 | US10030016, Example 4...)
Show SMILES CCOC(=O)c1cccnc1NCc1cc(OC(C)C)cc(c1)-c1cn(c2ncc(cc12)C(=O)NC1CC1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C35H35N5O6S/c1-4-45-35(42)29-11-8-14-36-32(29)37-19-23-15-24(17-27(16-23)46-22(2)3)31-21-40(47(43,44)28-9-6-5-7-10-28)33-30(31)18-25(20-38-33)34(41)39-26-12-13-26/h5-11,14-18,20-22,26H,4,12-13,19H2,1-3H3,(H,36,37)(H,39,41)
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UniChem
n/an/a<100n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM281947
PNG
(N-[(S)-(1-(3,4-Difluoro- phenyl)-ethyl]-2-({5- [4-...)
Show SMILES COCCNc1ncnc2ccc(cc12)-c1ccc(CNc2ncccc2C(=O)N[C@@H](C)c2ccc(F)c(F)c2)s1
Show InChI InChI=1S/C30H28F2N6O2S/c1-18(19-5-8-24(31)25(32)15-19)38-30(39)22-4-3-11-33-28(22)35-16-21-7-10-27(41-21)20-6-9-26-23(14-20)29(37-17-36-26)34-12-13-40-2/h3-11,14-15,17-18H,12-13,16H2,1-2H3,(H,33,35)(H,38,39)(H,34,36,37)/t18-/m0/s1
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UniChem
n/an/a<100n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM281949
PNG
(N-[(S)-(1-(3,4-Difluoro- phenyl)-ethyl]-2-({5- [4-...)
Show SMILES C[C@H](NC(=O)c1cccnc1NCc1ccc(s1)-c1ccc2ncnc(NC3COC3)c2c1)c1ccc(F)c(F)c1
Show InChI InChI=1S/C30H26F2N6O2S/c1-17(18-4-7-24(31)25(32)12-18)37-30(39)22-3-2-10-33-28(22)34-13-21-6-9-27(41-21)19-5-8-26-23(11-19)29(36-16-35-26)38-20-14-40-15-20/h2-12,16-17,20H,13-15H2,1H3,(H,33,34)(H,37,39)(H,35,36,38)/t17-/m0/s1
GoogleScholar
AffyNet 
UniChem
n/an/a<100n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM281952
PNG
(N-[(S)-(1-(3,4-Difluoro- phenyl)-ethyl]-2-({5- [4-...)
Show SMILES C[C@H](NC(=O)c1cccnc1NCc1ccc(s1)-c1ccc2ncnc(N3CC(CO)C3)c2c1)c1ccc(F)c(F)c1
Show InChI InChI=1S/C31H28F2N6O2S/c1-18(20-4-7-25(32)26(33)12-20)38-31(41)23-3-2-10-34-29(23)35-13-22-6-9-28(42-22)21-5-8-27-24(11-21)30(37-17-36-27)39-14-19(15-39)16-40/h2-12,17-19,40H,13-16H2,1H3,(H,34,35)(H,38,41)/t18-/m0/s1
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Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM281956
PNG
(2-(3-(4-(aminoquinazolin- 6-yl)-5-isopropoxy- benz...)
Show SMILES CC(C)Oc1cc(CNc2ncccc2C(=O)NCc2ccc(F)c(F)c2)cc(c1)-c1ccc2ncnc(N)c2c1
Show InChI InChI=1S/C31H28F2N6O2/c1-18(2)41-23-11-20(10-22(13-23)21-6-8-28-25(14-21)29(34)39-17-38-28)16-36-30-24(4-3-9-35-30)31(40)37-15-19-5-7-26(32)27(33)12-19/h3-14,17-18H,15-16H2,1-2H3,(H,35,36)(H,37,40)(H2,34,38,39)
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n/an/a<100n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM281964
PNG
(2-({[2-(4-aminoquinazolin- 6-yl)-1,3-thiazol-5-yl]...)
Show SMILES Nc1ncnc2ccc(cc12)-c1ncc(CNc2ncccc2C(=O)NCc2ccc(F)c(F)c2)s1
Show InChI InChI=1S/C25H19F2N7OS/c26-19-5-3-14(8-20(19)27)10-31-24(35)17-2-1-7-29-23(17)30-11-16-12-32-25(36-16)15-4-6-21-18(9-15)22(28)34-13-33-21/h1-9,12-13H,10-11H2,(H,29,30)(H,31,35)(H2,28,33,34)
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n/an/a<100n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM282009
PNG
(2-({[5-(4-aminoquinazolin- 6-yl)thiophen-2-yl] met...)
Show SMILES COc1cnc(NCc2ccc(s2)-c2ccc3ncnc(N)c3c2)c(c1)C(=O)NCc1ccc(F)c(F)c1
Show InChI InChI=1S/C27H22F2N6O2S/c1-37-17-10-20(27(36)33-11-15-2-5-21(28)22(29)8-15)26(31-12-17)32-13-18-4-7-24(38-18)16-3-6-23-19(9-16)25(30)35-14-34-23/h2-10,12,14H,11,13H2,1H3,(H,31,32)(H,33,36)(H2,30,34,35)
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n/an/a<100n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM282045
PNG
(2-({[5-(4-aminoquinazolin-6- yl)thiophen-2-yl]meth...)
Show SMILES CNS(=O)(=O)c1cnc(NCc2ccc(s2)-c2ccc3ncnc(N)c3c2)c(c1)C(=O)N[C@@H](C)c1ccc(F)c(F)c1
Show InChI InChI=1S/C28H25F2N7O3S2/c1-15(16-3-6-22(29)23(30)10-16)37-28(38)21-11-19(42(39,40)32-2)13-34-27(21)33-12-18-5-8-25(41-18)17-4-7-24-20(9-17)26(31)36-14-35-24/h3-11,13-15,32H,12H2,1-2H3,(H,33,34)(H,37,38)(H2,31,35,36)/t15-/m0/s1
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Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM282063
PNG
(2-({[5-(4-aminoquinazolin- 6-yl)thiophen-2-yl]meth...)
Show SMILES Nc1ncnc2ccc(cc12)-c1ccc(CNc2nc(ccc2C(=O)NCc2ccc(F)c(F)c2)C(F)(F)F)s1
Show InChI InChI=1S/C27H19F5N6OS/c28-19-5-1-14(9-20(19)29)11-35-26(39)17-4-8-23(27(30,31)32)38-25(17)34-12-16-3-7-22(40-16)15-2-6-21-18(10-15)24(33)37-13-36-21/h1-10,13H,11-12H2,(H,34,38)(H,35,39)(H2,33,36,37)
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Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM282093
PNG
(3-({[5-(4-aminoquinazolin- 6-yl)thiophen-2-yl]meth...)
Show SMILES C[C@H](NC(=O)c1cn(C)nc1NCc1ccc(s1)-c1ccc2ncnc(N)c2c1)c1ccc(F)cc1
Show InChI InChI=1S/C26H24FN7OS/c1-15(16-3-6-18(27)7-4-16)32-26(35)21-13-34(2)33-25(21)29-12-19-8-10-23(36-19)17-5-9-22-20(11-17)24(28)31-14-30-22/h3-11,13-15H,12H2,1-2H3,(H,29,33)(H,32,35)(H2,28,30,31)/t15-/m0/s1
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n/an/a<100n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM282108
PNG
(N-(3,4-Difluoro-benzyl)-2- ((E)-3-{3-[1-(2-ethyl-5...)
Show SMILES CCc1nc(C)c(\C=C2/C(=O)Nc3cc(\C=C\CNc4ncccc4C(=O)NCc4ccc(F)c(F)c4)ccc23)[nH]1
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Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM282142
PNG
((Z)-2-(2-(3-((1H- imidazol-5-yl)methylene)- 2-oxoi...)
Show SMILES Fc1ccc(CNC(=O)c2cccnc2NCCOc2ccc3\C(=C\c4cnc[nH]4)C(=O)Nc3c2)cc1F
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n/an/a<100n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM282154
PNG
(3-(4-(5-aminopyrazin-2-yl) benzylamino)-6-cyano- N...)
Show SMILES Nc1cnc(cn1)-c1ccc(CNc2ncc(nc2C(=O)Nc2ccc(F)cc2)C#N)cc1
Show InChI InChI=1S/C23H17FN8O/c24-16-5-7-17(8-6-16)32-23(33)21-22(30-11-18(9-25)31-21)29-10-14-1-3-15(4-2-14)19-12-28-20(26)13-27-19/h1-8,11-13H,10H2,(H2,26,28)(H,29,30)(H,32,33)
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n/an/a<100n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM282155
PNG
(2-(4-(3-amino-1H- pyrazolo[3,4-b]pyridin- 5-yl)ben...)
Show SMILES Nc1n[nH]c2ncc(cc12)-c1ccc(CNc2ncc(cc2C(=O)Nc2ccc(F)cc2)C#N)cc1
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Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM282176
PNG
(Synthesis of 2-(((6-(4-amino-7-methyl-7H-pyrrolo[2...)
Show SMILES Cn1cc(-c2ccc(CNc3ncc(cc3C(=O)Nc3ccc(F)cc3)C(F)(F)F)cn2)c2c(N)ncnc12
Show InChI InChI=1S/C26H20F4N8O/c1-38-12-19(21-22(31)35-13-36-24(21)38)20-7-2-14(9-32-20)10-33-23-18(8-15(11-34-23)26(28,29)30)25(39)37-17-5-3-16(27)4-6-17/h2-9,11-13H,10H2,1H3,(H,33,34)(H,37,39)(H2,31,35,36)
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Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM282183
PNG
(5-Cyano-N-[(S)-1-(4-fluoro-phenyl)-ethyl]-2-{[5-(1...)
Show SMILES C[C@H](NC(=O)c1cc(cnc1NCc1cnc(cn1)-c1cnc2[nH]ncc2c1)C#N)c1ccc(F)cc1
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n/an/a<100n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM282199
PNG
(3-{4-[5-Amino-6-(2- pyrrolidin-3-yl-ethyl)- pyrazi...)
Show SMILES C[C@H](NC(=O)c1nc(cnc1NCc1ccc(cc1)-c1cnc(N)c(CCC2CCNC2)n1)C#N)c1ccc(F)c(F)c1
Show InChI InChI=1S/C31H31F2N9O/c1-18(22-7-8-24(32)25(33)12-22)40-31(43)28-30(39-16-23(13-34)41-28)38-15-19-2-5-21(6-3-19)27-17-37-29(35)26(42-27)9-4-20-10-11-36-14-20/h2-3,5-8,12,16-18,20,36H,4,9-11,14-15H2,1H3,(H2,35,37)(H,38,39)(H,40,43)/t18-,20?/m0/s1
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Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM282208
PNG
(2-{4-[5-Amino-6-(3- morpholin-4-yl-propyl)- pyrazi...)
Show SMILES C[C@H](NC(=O)c1cc(cnc1NCc1ccc(cc1)-c1cnc(N)c(CCCN2CCOCC2)n1)C#N)c1ccc(F)cc1
Show InChI InChI=1S/C33H35FN8O2/c1-22(25-8-10-27(34)11-9-25)40-33(43)28-17-24(18-35)20-39-32(28)38-19-23-4-6-26(7-5-23)30-21-37-31(36)29(41-30)3-2-12-42-13-15-44-16-14-42/h4-11,17,20-22H,2-3,12-16,19H2,1H3,(H2,36,37)(H,38,39)(H,40,43)/t22-/m0/s1
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n/an/a<100n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM282266
PNG
((S)-5-cyano-2-(4-(3-(3- (dimethylamino)prop-1- yny...)
Show SMILES C[C@H](NC(=O)c1cc(cnc1NCc1ccc(cc1)-c1cnc2[nH]nc(C#CCN(C)C)c2c1)C#N)c1ccc(F)cc1
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n/an/a<100n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM282267
PNG
((S)-5-cyano-N-(1-(4- fluorophenyl)ethyl)-2- (4-(3-...)
Show SMILES CCCc1n[nH]c2ncc(cc12)-c1ccc(CNc2ncc(cc2C(=O)N[C@@H](C)c2ccc(F)cc2)C#N)cc1
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n/an/a<100n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM282268
PNG
((S)-2-amino-5-(4-((5-cyano- 3-(1-(4-fluorophenyl) ...)
Show SMILES C[C@H](NC(=O)c1cc(cnc1NCc1ccc(cc1)-c1cnc(N)c(c1)C(O)=O)C#N)c1ccc(F)cc1
Show InChI InChI=1S/C28H23FN6O3/c1-16(19-6-8-22(29)9-7-19)35-27(36)24-10-18(12-30)14-34-26(24)33-13-17-2-4-20(5-3-17)21-11-23(28(37)38)25(31)32-15-21/h2-11,14-16H,13H2,1H3,(H2,31,32)(H,33,34)(H,35,36)(H,37,38)/t16-/m0/s1
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n/an/a<100n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM282271
PNG
((S)-5-cyano-2-(4-(3- ((dimethylamino)methyl)- 1H-p...)
Show SMILES C[C@H](NC(=O)c1cc(cnc1NCc1ccc(cc1)-c1cnc2[nH]nc(CN(C)C)c2c1)C#N)c1ccc(F)cc1
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n/an/a<100n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM282276
PNG
(2-(4-(1H-pyrazolo[3,4-b] pyridin-5-yl)benzylamino)...)
Show SMILES Fc1ccc(NC(=O)c2cc(cnc2NCc2ccc(cc2)-c2cnc3[nH]ncc3c2)C(F)(F)F)cc1
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Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM282280
PNG
(2-{4-[5-Amino-6-((R)- pyrrolidin-3-yloxy)- pyrazin...)
Show SMILES C[C@H](NC(=O)c1cc(cnc1NCc1ccc(cc1)-c1cnc(N)c(O[C@@H]2CCNC2)n1)C#N)c1ccc(F)cc1
Show InChI InChI=1S/C30H29FN8O2/c1-18(21-6-8-23(31)9-7-21)38-29(40)25-12-20(13-32)15-37-28(25)36-14-19-2-4-22(5-3-19)26-17-35-27(33)30(39-26)41-24-10-11-34-16-24/h2-9,12,15,17-18,24,34H,10-11,14,16H2,1H3,(H2,33,35)(H,36,37)(H,38,40)/t18-,24+/m0/s1
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n/an/a<100n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM282294
PNG
(Synthesis of 2-[4-(4-Amino-pyrrolo[2,1-f][1,2,4]tr...)
Show SMILES C[C@H](NC(=O)c1cc(cnc1NCc1ccc(cc1)-c1ccn2ncnc(N)c12)C#N)c1ccc(F)cc1
Show InChI InChI=1S/C28H23FN8O/c1-17(20-6-8-22(29)9-7-20)36-28(38)24-12-19(13-30)15-33-27(24)32-14-18-2-4-21(5-3-18)23-10-11-37-25(23)26(31)34-16-35-37/h2-12,15-17H,14H2,1H3,(H,32,33)(H,36,38)(H2,31,34,35)/t17-/m0/s1
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n/an/a<100n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM282297
PNG
(2-[4-(4-Amino-pyrrolo [2,1-f][1,2,4]triazin- 5-yl)...)
Show SMILES Nc1ncnn2ccc(-c3ccc(CNc4ncc(cc4C(=O)Nc4ccc(F)cc4)C(F)(F)F)cc3)c12
Show InChI InChI=1S/C26H19F4N7O/c27-18-5-7-19(8-6-18)36-25(38)21-11-17(26(28,29)30)13-33-24(21)32-12-15-1-3-16(4-2-15)20-9-10-37-22(20)23(31)34-14-35-37/h1-11,13-14H,12H2,(H,32,33)(H,36,38)(H2,31,34,35)
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n/an/a<100n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM282302
PNG
(Synthesis of 3-[4-(3-Amino-1H-pyrazolo[3,4-b]pyraz...)
Show SMILES C[C@H](NC(=O)c1nc(cnc1NCc1ccc(cc1)-c1cnc2[nH]nc(N)c2n1)C#N)c1ccc(F)c(F)c1
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n/an/a<100n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM282309
PNG
(2-{4-[5-Amino-6-((R)-3- amino-piperidin-1-yl)- pyr...)
Show SMILES N[C@@H]1CCCN(C1)c1nc(cnc1N)-c1ccc(CNc2ncc(cc2C(=O)Nc2ccc(F)cc2)C(F)(F)F)cc1
Show InChI InChI=1S/C29H28F4N8O/c30-20-7-9-22(10-8-20)39-28(42)23-12-19(29(31,32)33)14-38-26(23)37-13-17-3-5-18(6-4-17)24-15-36-25(35)27(40-24)41-11-1-2-21(34)16-41/h3-10,12,14-15,21H,1-2,11,13,16,34H2,(H2,35,36)(H,37,38)(H,39,42)/t21-/m1/s1
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n/an/a<100n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM282313
PNG
(2-[4-(3'-Amino-3,4,5,6- tetrahydro-2H-[1,2'] bipyr...)
Show SMILES Nc1ncc(nc1N1CCNCC1)-c1ccc(CNc2ncc(cc2C(=O)Nc2ccc(F)cc2)C(F)(F)F)cc1
Show InChI InChI=1S/C28H26F4N8O/c29-20-5-7-21(8-6-20)38-27(41)22-13-19(28(30,31)32)15-37-25(22)36-14-17-1-3-18(4-2-17)23-16-35-24(33)26(39-23)40-11-9-34-10-12-40/h1-8,13,15-16,34H,9-12,14H2,(H2,33,35)(H,36,37)(H,38,41)
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n/an/a<100n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM282321
PNG
(Synthesis of (S)-2-(4-(6-amino-5-carbamoylpyridin-...)
Show SMILES C[C@H](NC(=O)c1cc(cnc1NCc1ccc(cc1)-c1cnc(N)c(c1)C(N)=O)C#N)c1ccc(F)cc1
Show InChI InChI=1S/C28H24FN7O2/c1-16(19-6-8-22(29)9-7-19)36-28(38)24-10-18(12-30)14-35-27(24)34-13-17-2-4-20(5-3-17)21-11-23(26(32)37)25(31)33-15-21/h2-11,14-16H,13H2,1H3,(H2,31,33)(H2,32,37)(H,34,35)(H,36,38)/t16-/m0/s1
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n/an/a<100n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM282357
PNG
(2-{4-[5-Amino-6-(3-amino- phenyl)-pyrazin-2-yl]- b...)
Show SMILES C[C@H](NC(=O)c1cc(cnc1NCc1ccc(cc1)-c1cnc(N)c(n1)-c1cccc(N)c1)C#N)c1ccc(F)cc1
Show InChI InChI=1S/C32H27FN8O/c1-19(22-9-11-25(33)12-10-22)40-32(42)27-13-21(15-34)17-39-31(27)38-16-20-5-7-23(8-6-20)28-18-37-30(36)29(41-28)24-3-2-4-26(35)14-24/h2-14,17-19H,16,35H2,1H3,(H2,36,37)(H,38,39)(H,40,42)/t19-/m0/s1
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n/an/a<100n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM282365
PNG
(2-{4-[5-Amino-6-(2,3- dihydroxy-propylamino)- pyra...)
Show SMILES Nc1ncc(nc1NCC(O)CO)-c1ccc(CNc2ncc(cc2C(=O)Nc2ccc(F)cc2)C(F)(F)F)cc1
Show InChI InChI=1S/C27H25F4N7O3/c28-18-5-7-19(8-6-18)37-26(41)21-9-17(27(29,30)31)11-35-24(21)34-10-15-1-3-16(4-2-15)22-13-33-23(32)25(38-22)36-12-20(40)14-39/h1-9,11,13,20,39-40H,10,12,14H2,(H2,32,33)(H,34,35)(H,36,38)(H,37,41)
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UniChem
n/an/a<100n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%