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Patent code US10030020

Compile Data Set for Download or QSAR

Found 677 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Monoglyceride lipase


(Homo sapiens (human))
BDBM280664
PNG
(US10030020, Example 211)
PDB
MMDB

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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with varying...


US Patent US10030020 (2018)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (human))
BDBM280665
PNG
(US10030020, Example 214)
PDB
MMDB

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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with varying...


US Patent US10030020 (2018)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (human))
BDBM280668
PNG
(US10030020, Example 217)
PDB
MMDB

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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with varying...


US Patent US10030020 (2018)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (human))
BDBM280684
PNG
(US10030020, Example 236)
PDB
MMDB

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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with varying...


US Patent US10030020 (2018)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (human))
BDBM280688
PNG
(US10030020, Example 240)
PDB
MMDB

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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with varying...


US Patent US10030020 (2018)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (human))
BDBM280692
PNG
(US10030020, Example 245)
PDB
MMDB

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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with varying...


US Patent US10030020 (2018)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (human))
BDBM280710
PNG
(US10030020, Example 268)
PDB
MMDB

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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with varying...


US Patent US10030020 (2018)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (human))
BDBM280713
PNG
(US10030020, Example 271)
PDB
MMDB

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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with varying...


US Patent US10030020 (2018)

More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Mus musculus (mouse))
BDBM280476
PNG
(US10030020, Example 21)
Show SMILES FC(F)(F)C(OC(=O)N1CCC2(CCN(Cc3ccc(Cl)cc3N3CCOCC3)C2)CC1)C(F)(F)F
Show InChI InChI=1S/C23H28ClF6N3O3/c24-17-2-1-16(18(13-17)32-9-11-35-12-10-32)14-31-6-3-21(15-31)4-7-33(8-5-21)20(34)36-19(22(25,26)27)23(28,29)30/h1-2,13,19H,3-12,14-15H2
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction or cell lysates) (50 μL, 1.0 mg/mL total protein concentration) were preincubated with varying concentr...


US Patent US10030020 (2018)

More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Mus musculus (mouse))
BDBM280491
PNG
(US10030020, Example 36)
Show SMILES FC(F)(F)C(OC(=O)N1CCC2(CCCN2Cc2cc(cc(c2)C(F)(F)F)N2CCCC2)CC1)C(F)(F)F
Show InChI InChI=1S/C24H28F9N3O2/c25-22(26,27)17-12-16(13-18(14-17)34-7-1-2-8-34)15-36-9-3-4-21(36)5-10-35(11-6-21)20(37)38-19(23(28,29)30)24(31,32)33/h12-14,19H,1-11,15H2
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction or cell lysates) (50 μL, 1.0 mg/mL total protein concentration) were preincubated with varying concentr...


US Patent US10030020 (2018)

More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Mus musculus (mouse))
BDBM280492
PNG
(US10030020, Example 37)
Show SMILES FC(F)(F)Oc1cc(CN2CCCC22CCN(CC2)C(=O)OC(C(F)(F)F)C(F)(F)F)cc(c1)N1CCOCC1
Show InChI InChI=1S/C24H28F9N3O4/c25-22(26,27)19(23(28,29)30)39-20(37)35-6-3-21(4-7-35)2-1-5-36(21)15-16-12-17(34-8-10-38-11-9-34)14-18(13-16)40-24(31,32)33/h12-14,19H,1-11,15H2
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction or cell lysates) (50 μL, 1.0 mg/mL total protein concentration) were preincubated with varying concentr...


US Patent US10030020 (2018)

More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Mus musculus (mouse))
BDBM280505
PNG
(US10030020, Example 50)
Show SMILES CC1(C)CC2(CN1Cc1ccc(Cl)cc1N1CCOCC1)CCN(CC2)C(=O)OC(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C25H32ClF6N3O3/c1-22(2)15-23(5-7-34(8-6-23)21(36)38-20(24(27,28)29)25(30,31)32)16-35(22)14-17-3-4-18(26)13-19(17)33-9-11-37-12-10-33/h3-4,13,20H,5-12,14-16H2,1-2H3
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction or cell lysates) (50 μL, 1.0 mg/mL total protein concentration) were preincubated with varying concentr...


US Patent US10030020 (2018)

More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Mus musculus (mouse))
BDBM280515
PNG
(US10030020, Example 60)
Show SMILES FC(F)(F)C(OC(=O)N1CCC2(CCCN2Cc2ccccc2Cl)CC1)C(F)(F)F
Show InChI InChI=1S/C19H21ClF6N2O2/c20-14-5-2-1-4-13(14)12-28-9-3-6-17(28)7-10-27(11-8-17)16(29)30-15(18(21,22)23)19(24,25)26/h1-2,4-5,15H,3,6-12H2
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction or cell lysates) (50 μL, 1.0 mg/mL total protein concentration) were preincubated with varying concentr...


US Patent US10030020 (2018)

More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Mus musculus (mouse))
BDBM280541
PNG
(US10030020, Example 86)
Show SMILES Cc1c(CN2CCCC22CCN(CC2)C(=O)OC(C(F)(F)F)C(F)(F)F)cccc1N1CC2CCC(C1)O2
Show InChI InChI=1S/C26H33F6N3O3/c1-17-18(4-2-5-21(17)34-15-19-6-7-20(16-34)37-19)14-35-11-3-8-24(35)9-12-33(13-10-24)23(36)38-22(25(27,28)29)26(30,31)32/h2,4-5,19-20,22H,3,6-16H2,1H3
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction or cell lysates) (50 μL, 1.0 mg/mL total protein concentration) were preincubated with varying concentr...


US Patent US10030020 (2018)

More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Mus musculus (mouse))
BDBM280545
PNG
(US10030020, Example 90)
Show SMILES FC(F)(F)C(OC(=O)N1CCC2(CCCN2Cc2ccc(cc2N2CCC(F)(F)CC2)C(F)(F)F)CC1)C(F)(F)F
Show InChI InChI=1S/C25H28F11N3O2/c26-22(27)7-12-37(13-8-22)18-14-17(23(28,29)30)3-2-16(18)15-39-9-1-4-21(39)5-10-38(11-6-21)20(40)41-19(24(31,32)33)25(34,35)36/h2-3,14,19H,1,4-13,15H2
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction or cell lysates) (50 μL, 1.0 mg/mL total protein concentration) were preincubated with varying concentr...


US Patent US10030020 (2018)

More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Mus musculus (mouse))
BDBM280586
PNG
(US10030020, Example 131)
Show SMILES FC(F)(F)C(OC(=O)N1CCC2(CCCN2Cc2ccc(Cl)c(c2)N2CCOCC2)CC1)C(F)(F)F
Show InChI InChI=1S/C23H28ClF6N3O3/c24-17-3-2-16(14-18(17)31-10-12-35-13-11-31)15-33-7-1-4-21(33)5-8-32(9-6-21)20(34)36-19(22(25,26)27)23(28,29)30/h2-3,14,19H,1,4-13,15H2
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction or cell lysates) (50 μL, 1.0 mg/mL total protein concentration) were preincubated with varying concentr...


US Patent US10030020 (2018)

More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Mus musculus (mouse))
BDBM280588
PNG
(US10030020, Example 133)
Show SMILES FC(F)(F)C(OC(=O)N1CCC2(CCCN2Cc2ccc(c(c2)N2CCOCC2)C(F)(F)F)CC1)C(F)(F)F
Show InChI InChI=1S/C24H28F9N3O3/c25-22(26,27)17-3-2-16(14-18(17)34-10-12-38-13-11-34)15-36-7-1-4-21(36)5-8-35(9-6-21)20(37)39-19(23(28,29)30)24(31,32)33/h2-3,14,19H,1,4-13,15H2
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction or cell lysates) (50 μL, 1.0 mg/mL total protein concentration) were preincubated with varying concentr...


US Patent US10030020 (2018)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (human))
BDBM280588
PNG
(US10030020, Example 133)
Show SMILES FC(F)(F)C(OC(=O)N1CCC2(CCCN2Cc2ccc(c(c2)N2CCOCC2)C(F)(F)F)CC1)C(F)(F)F
Show InChI InChI=1S/C24H28F9N3O3/c25-22(26,27)17-3-2-16(14-18(17)34-10-12-38-13-11-34)15-36-7-1-4-21(36)5-8-35(9-6-21)20(37)39-19(23(28,29)30)24(31,32)33/h2-3,14,19H,1,4-13,15H2
PDB
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with varying...


US Patent US10030020 (2018)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (human))
BDBM280589
PNG
(US10030020, Example 134)
Show SMILES FC(F)(F)C(OC(=O)N1CCC2(CCCN2Cc2ccc(c(c2)N2CCCC2)C(F)(F)F)CC1)C(F)(F)F
Show InChI InChI=1S/C24H28F9N3O2/c25-22(26,27)17-5-4-16(14-18(17)34-9-1-2-10-34)15-36-11-3-6-21(36)7-12-35(13-8-21)20(37)38-19(23(28,29)30)24(31,32)33/h4-5,14,19H,1-3,6-13,15H2
PDB
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with varying...


US Patent US10030020 (2018)

More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Mus musculus (mouse))
BDBM280590
PNG
(US10030020, Example 135)
Show SMILES Cc1cc(CN2CCC3(C2)CCN(CC3)C(=O)OC(C(F)(F)F)C(F)(F)F)ccc1Cl
Show InChI InChI=1S/C20H23ClF6N2O2/c1-13-10-14(2-3-15(13)21)11-28-7-4-18(12-28)5-8-29(9-6-18)17(30)31-16(19(22,23)24)20(25,26)27/h2-3,10,16H,4-9,11-12H2,1H3
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction or cell lysates) (50 μL, 1.0 mg/mL total protein concentration) were preincubated with varying concentr...


US Patent US10030020 (2018)

More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Mus musculus (mouse))
BDBM280605
PNG
(US10030020, Example 150)
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction or cell lysates) (50 μL, 1.0 mg/mL total protein concentration) were preincubated with varying concentr...


US Patent US10030020 (2018)

More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Mus musculus (mouse))
BDBM280611
PNG
(US10030020, Example 156)
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction or cell lysates) (50 μL, 1.0 mg/mL total protein concentration) were preincubated with varying concentr...


US Patent US10030020 (2018)

More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Mus musculus (mouse))
BDBM280630
PNG
(US10030020, Example 175)
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction or cell lysates) (50 μL, 1.0 mg/mL total protein concentration) were preincubated with varying concentr...


US Patent US10030020 (2018)

More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Mus musculus (mouse))
BDBM280642
PNG
(US10030020, Example 187)
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction or cell lysates) (50 μL, 1.0 mg/mL total protein concentration) were preincubated with varying concentr...


US Patent US10030020 (2018)

More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Mus musculus (mouse))
BDBM280650
PNG
(US10030020, Example 195)
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction or cell lysates) (50 μL, 1.0 mg/mL total protein concentration) were preincubated with varying concentr...


US Patent US10030020 (2018)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (human))
BDBM280659
PNG
(US10030020, Example 204)
PDB
MMDB

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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with varying...


US Patent US10030020 (2018)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (human))
BDBM280666
PNG
(US10030020, Example 215)
PDB
MMDB

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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with varying...


US Patent US10030020 (2018)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (human))
BDBM280678
PNG
(US10030020, Example 230)
PDB
MMDB

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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with varying...


US Patent US10030020 (2018)

More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Mus musculus (mouse))
BDBM280465
PNG
(US10030020, Example 10)
Show SMILES COc1c(Cl)cccc1CN1CCCC11CCN(CC1)C(=O)OC(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C20H23ClF6N2O3/c1-31-15-13(4-2-5-14(15)21)12-29-9-3-6-18(29)7-10-28(11-8-18)17(30)32-16(19(22,23)24)20(25,26)27/h2,4-5,16H,3,6-12H2,1H3
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction or cell lysates) (50 μL, 1.0 mg/mL total protein concentration) were preincubated with varying concentr...


US Patent US10030020 (2018)

More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Mus musculus (mouse))
BDBM280474
PNG
(US10030020, Example 19)
Show SMILES FCCN1CCN(CC1)c1cc(Cl)ccc1CN1CCCC11CCN(CC1)C(=O)OC(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C25H32ClF7N4O2/c26-19-3-2-18(20(16-19)35-14-12-34(11-7-27)13-15-35)17-37-8-1-4-23(37)5-9-36(10-6-23)22(38)39-21(24(28,29)30)25(31,32)33/h2-3,16,21H,1,4-15,17H2
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction or cell lysates) (50 μL, 1.0 mg/mL total protein concentration) were preincubated with varying concentr...


US Patent US10030020 (2018)

More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Mus musculus (mouse))
BDBM280485
PNG
(US10030020, Example 30)
Show SMILES FCCOc1cc(Cl)ccc1CN1CCCC11CCN(CC1)C(=O)OC(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C21H24ClF7N2O3/c22-15-3-2-14(16(12-15)33-11-7-23)13-31-8-1-4-19(31)5-9-30(10-6-19)18(32)34-17(20(24,25)26)21(27,28)29/h2-3,12,17H,1,4-11,13H2
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction or cell lysates) (50 μL, 1.0 mg/mL total protein concentration) were preincubated with varying concentr...


US Patent US10030020 (2018)

More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Mus musculus (mouse))
BDBM280486
PNG
(US10030020, Example 31)
Show SMILES FCCOc1ccc(CN2CCCC22CCN(CC2)C(=O)OC(C(F)(F)F)C(F)(F)F)cc1
Show InChI InChI=1S/C21H25F7N2O3/c22-9-13-32-16-4-2-15(3-5-16)14-30-10-1-6-19(30)7-11-29(12-8-19)18(31)33-17(20(23,24)25)21(26,27)28/h2-5,17H,1,6-14H2
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction or cell lysates) (50 μL, 1.0 mg/mL total protein concentration) were preincubated with varying concentr...


US Patent US10030020 (2018)

More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Mus musculus (mouse))
BDBM280495
PNG
(US10030020, Example 40)
Show SMILES CS(=O)(=O)N1CCN(CC1)c1cc(Cl)cc(CN2CCCC22CCN(CC2)C(=O)OC(C(F)(F)F)C(F)(F)F)c1
Show InChI InChI=1S/C24H31ClF6N4O4S/c1-40(37,38)35-11-9-32(10-12-35)19-14-17(13-18(25)15-19)16-34-6-2-3-22(34)4-7-33(8-5-22)21(36)39-20(23(26,27)28)24(29,30)31/h13-15,20H,2-12,16H2,1H3
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction or cell lysates) (50 μL, 1.0 mg/mL total protein concentration) were preincubated with varying concentr...


US Patent US10030020 (2018)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (human))
BDBM280523
PNG
(US10030020, Example 68)
Show SMILES CN1CCCc2ccc(CN3CCCC33CCN(CC3)C(=O)OC(C(F)(F)F)C(F)(F)F)cc12
Show InChI InChI=1S/C23H29F6N3O2/c1-30-10-2-4-17-6-5-16(14-18(17)30)15-32-11-3-7-21(32)8-12-31(13-9-21)20(33)34-19(22(24,25)26)23(27,28)29/h5-6,14,19H,2-4,7-13,15H2,1H3
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with varying...


US Patent US10030020 (2018)

More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Mus musculus (mouse))
BDBM280556
PNG
(US10030020, Example 101)
Show SMILES FC(F)(F)C(OC(=O)N1CCC2(CCCN2Cc2ccc(Cl)cc2N2CCC(F)(F)CC2)CC1)C(F)(F)F
Show InChI InChI=1S/C24H28ClF8N3O2/c25-17-3-2-16(18(14-17)34-12-7-22(26,27)8-13-34)15-36-9-1-4-21(36)5-10-35(11-6-21)20(37)38-19(23(28,29)30)24(31,32)33/h2-3,14,19H,1,4-13,15H2
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction or cell lysates) (50 μL, 1.0 mg/mL total protein concentration) were preincubated with varying concentr...


US Patent US10030020 (2018)

More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Mus musculus (mouse))
BDBM280560
PNG
(US10030020, Example 105)
Show SMILES CS(=O)(=O)NC1CCN(CC1)c1cc(Cl)ccc1CN1CCCC11CCN(CC1)C(=O)OC(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C25H33ClF6N4O4S/c1-41(38,39)33-19-5-11-34(12-6-19)20-15-18(26)4-3-17(20)16-36-10-2-7-23(36)8-13-35(14-9-23)22(37)40-21(24(27,28)29)25(30,31)32/h3-4,15,19,21,33H,2,5-14,16H2,1H3
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction or cell lysates) (50 μL, 1.0 mg/mL total protein concentration) were preincubated with varying concentr...


US Patent US10030020 (2018)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (human))
BDBM280576
PNG
(US10030020, Example 121)
Show SMILES OC(=O)C1CCN(CC1)c1cc(ccc1CN1CCCC11CCN(CC1)C(=O)OC(C(F)(F)F)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C26H30F9N3O4/c27-24(28,29)18-3-2-17(19(14-18)36-10-4-16(5-11-36)20(39)40)15-38-9-1-6-23(38)7-12-37(13-8-23)22(41)42-21(25(30,31)32)26(33,34)35/h2-3,14,16,21H,1,4-13,15H2,(H,39,40)
PDB
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with varying...


US Patent US10030020 (2018)

More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Mus musculus (mouse))
BDBM280581
PNG
(US10030020, Example 126)
Show SMILES FC(F)(F)C(OC(=O)N1CCC2(CCCN2Cc2ccc3OCCOc3c2)CC1)C(F)(F)F
Show InChI InChI=1S/C21H24F6N2O4/c22-20(23,24)17(21(25,26)27)33-18(30)28-8-5-19(6-9-28)4-1-7-29(19)13-14-2-3-15-16(12-14)32-11-10-31-15/h2-3,12,17H,1,4-11,13H2
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction or cell lysates) (50 μL, 1.0 mg/mL total protein concentration) were preincubated with varying concentr...


US Patent US10030020 (2018)

More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Mus musculus (mouse))
BDBM280589
PNG
(US10030020, Example 134)
Show SMILES FC(F)(F)C(OC(=O)N1CCC2(CCCN2Cc2ccc(c(c2)N2CCCC2)C(F)(F)F)CC1)C(F)(F)F
Show InChI InChI=1S/C24H28F9N3O2/c25-22(26,27)17-5-4-16(14-18(17)34-9-1-2-10-34)15-36-11-3-6-21(36)7-12-35(13-8-21)20(37)38-19(23(28,29)30)24(31,32)33/h4-5,14,19H,1-3,6-13,15H2
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction or cell lysates) (50 μL, 1.0 mg/mL total protein concentration) were preincubated with varying concentr...


US Patent US10030020 (2018)

More data for this
Ligand-Target Pair
Monoacylglycerol lipase ABHD2


(Mus musculus (Mouse))
BDBM280592
PNG
(US10030020, Example 137)
Show SMILES FC(F)(F)C(OC(=O)N1CCC2(CCN(Cc3ccc4OCCOc4c3)C2)CC1)C(F)(F)F
Show InChI InChI=1S/C21H24F6N2O4/c22-20(23,24)17(21(25,26)27)33-18(30)29-7-4-19(5-8-29)3-6-28(13-19)12-14-1-2-15-16(11-14)32-10-9-31-15/h1-2,11,17H,3-10,12-13H2
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction or cell lysates) (50 μL, 1.0 mg/mL total protein concentration) were preincubated with varying concentr...


US Patent US10030020 (2018)

More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Mus musculus (mouse))
BDBM280587
PNG
(US10030020, Example 132)
Show SMILES FC(F)(F)C(OC(=O)N1CCC2(CCCN2Cc2ccc(Cl)c(c2)N2CCCC2)CC1)C(F)(F)F
Show InChI InChI=1S/C23H28ClF6N3O2/c24-17-5-4-16(14-18(17)31-9-1-2-10-31)15-33-11-3-6-21(33)7-12-32(13-8-21)20(34)35-19(22(25,26)27)23(28,29)30/h4-5,14,19H,1-3,6-13,15H2
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction or cell lysates) (50 μL, 1.0 mg/mL total protein concentration) were preincubated with varying concentr...


US Patent US10030020 (2018)

More data for this
Ligand-Target Pair
Monoacylglycerol lipase ABHD2


(Mus musculus (Mouse))
BDBM280593
PNG
(US10030020, Example 138)
Show SMILES FC(F)(F)C(OC(=O)N1CCC2(CCN(Cc3ccc(N4CCOCC4)c(Cl)c3)C2)CC1)C(F)(F)F
Show InChI InChI=1S/C23H28ClF6N3O3/c24-17-13-16(1-2-18(17)32-9-11-35-12-10-32)14-31-6-3-21(15-31)4-7-33(8-5-21)20(34)36-19(22(25,26)27)23(28,29)30/h1-2,13,19H,3-12,14-15H2
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction or cell lysates) (50 μL, 1.0 mg/mL total protein concentration) were preincubated with varying concentr...


US Patent US10030020 (2018)

More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Mus musculus (mouse))
BDBM280595
PNG
(US10030020, Example 140)
Show SMILES FC(F)(F)C(OC(=O)N1CCC2(CCN(Cc3ccc(N4CCOCC4)c(c3)C(F)(F)F)C2)CC1)C(F)(F)F
Show InChI InChI=1S/C24H28F9N3O3/c25-22(26,27)17-13-16(1-2-18(17)35-9-11-38-12-10-35)14-34-6-3-21(15-34)4-7-36(8-5-21)20(37)39-19(23(28,29)30)24(31,32)33/h1-2,13,19H,3-12,14-15H2
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction or cell lysates) (50 μL, 1.0 mg/mL total protein concentration) were preincubated with varying concentr...


US Patent US10030020 (2018)

More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Mus musculus (mouse))
BDBM280633
PNG
(US10030020, Example 178)
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction or cell lysates) (50 μL, 1.0 mg/mL total protein concentration) were preincubated with varying concentr...


US Patent US10030020 (2018)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (human))
BDBM280634
PNG
(US10030020, Example 179)
PDB
MMDB

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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with varying...


US Patent US10030020 (2018)

More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Mus musculus (mouse))
BDBM280644
PNG
(US10030020, Example 189)
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction or cell lysates) (50 μL, 1.0 mg/mL total protein concentration) were preincubated with varying concentr...


US Patent US10030020 (2018)

More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Mus musculus (mouse))
BDBM280647
PNG
(US10030020, Example 192)
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction or cell lysates) (50 μL, 1.0 mg/mL total protein concentration) were preincubated with varying concentr...


US Patent US10030020 (2018)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (human))
BDBM280650
PNG
(US10030020, Example 195)
PDB
MMDB

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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with varying...


US Patent US10030020 (2018)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (human))
BDBM280652
PNG
(US10030020, Example 197)
PDB
MMDB

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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with varying...


US Patent US10030020 (2018)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (human))
BDBM280662
PNG
(US10030020, Example 209)
PDB
MMDB

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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with varying...


US Patent US10030020 (2018)

More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 677 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%