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Patent code US10035814

Compile Data Set for Download or QSAR
Found 18 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Telomerase protein component 1


(Homo sapiens (human))
BDBM279794
PNG
(PM(3)BG | US10035814, Compound 142916)
Show SMILES CC[C@H](Cn1cnc2c1nc(N)[nH]c2=O)OCP(O)(=O)OP(O)(=O)OP(O)(O)=O
GoogleScholar
AffyNet 
UniChem
n/an/an/an/a 1.00E+4n/an/an/an/a



Geron Corporation

US Patent


Assay Description
(((Guanine-9-yl) propan-2-oxy) methyl) phosphonic acid diphosphate (PMPGpp) acts as a chain terminator and competes with dGTP.Purified human telomera...


US Patent US10035814 (2018)

More data for this
Ligand-Target Pair
exvivo trap3 day assay


(Homo sapiens (human))
BDBM279808
PNG
(US10035814, Compound 142942 | bis-PMPG spermine)
Show SMILES CC(Cn1cnc2c1nc(N)[nH]c2=O)OCP(O)(=O)NCCCNCCCCNCCCNP(O)(=O)COC(C)Cn1cnc2c1nc(N)[nH]c2=O
GoogleScholar
AffyNet 
UniChem
n/an/an/an/a 1.84E+3n/an/an/an/a



Geron Corporation

US Patent


Assay Description
Telomerase inhibition is observed in cells following the addition of the prodrugs (R)-PMPG-diisopropyloxy ester or (S)-PMPG-diisopropyloxy ester. HT3...


US Patent US10035814 (2018)

More data for this
Ligand-Target Pair
exvivo trap3 day assay


(Homo sapiens (human))
BDBM279801
PNG
(PMPG prodrug, R form | US10035814, Compound 142715)
Show SMILES CC(C)OC(=O)OCOP(=O)(COC(C)Cn1cnc2c1nc(N)[nH]c2=O)OCOC(=O)OC(C)C
GoogleScholar
AffyNet 
UniChem
n/an/an/an/a 2.15E+3n/an/an/an/a



Geron Corporation

US Patent


Assay Description
Telomerase inhibition is observed in cells following the addition of the prodrugs (R)-PMPG-diisopropyloxy ester or (S)-PMPG-diisopropyloxy ester. HT3...


US Patent US10035814 (2018)

More data for this
Ligand-Target Pair
Telomerase protein component 1


(Homo sapiens (human))
BDBM279791
PNG
(PMPG free acid, R form | US10035814, Compound 1426...)
Show SMILES CC(Cn1cnc2c1nc(N)[nH]c2=O)OCP(O)(=O)OP(O)(=O)OP(O)(O)=O
GoogleScholar
AffyNet 
UniChem
n/an/an/an/a 850n/an/an/an/a



Geron Corporation

US Patent


Assay Description
(((Guanine-9-yl) propan-2-oxy) methyl) phosphonic acid diphosphate (PMPGpp) acts as a chain terminator and competes with dGTP.Purified human telomera...


US Patent US10035814 (2018)

More data for this
Ligand-Target Pair
Telomerase protein component 1


(Homo sapiens (human))
BDBM279792
PNG
(6-thio-G- phosphonate (6-S-PMPG), R form | US10035...)
Show SMILES CC(Cn1cnc2c1nc(N)[nH]c2=S)OCP(O)(=O)OP(O)(=O)OP(O)(O)=O
GoogleScholar
AffyNet 
UniChem
n/an/an/an/a 1.35E+4n/an/an/an/a



Geron Corporation

US Patent


Assay Description
(((Guanine-9-yl) propan-2-oxy) methyl) phosphonic acid diphosphate (PMPGpp) acts as a chain terminator and competes with dGTP.Purified human telomera...


US Patent US10035814 (2018)

More data for this
Ligand-Target Pair
exvivo trap3 day assay


(Homo sapiens (human))
BDBM279803
PNG
(PMIBeG free acid | US10035814, Compound 142811)
Show SMILES Nc1nc2n(CC(=C)COCP(O)(O)=O)cnc2c(=O)[nH]1
GoogleScholar
AffyNet 
UniChem
n/an/an/an/a 2.60E+3n/an/an/an/a



Geron Corporation

US Patent


Assay Description
Telomerase inhibition is observed in cells following the addition of the prodrugs (R)-PMPG-diisopropyloxy ester or (S)-PMPG-diisopropyloxy ester. HT3...


US Patent US10035814 (2018)

More data for this
Ligand-Target Pair
Telomerase protein component 1


(Homo sapiens (human))
BDBM279796
PNG
(FPMPG | US10035814, Compound 142856)
Show SMILES Nc1nc2n(CC(CF)OCP(O)(=O)OP(O)(=O)OP(O)(O)=O)cnc2c(=O)[nH]1
GoogleScholar
AffyNet 
UniChem
n/an/an/an/a 7.50E+3n/an/an/an/a



Geron Corporation

US Patent


Assay Description
(((Guanine-9-yl) propan-2-oxy) methyl) phosphonic acid diphosphate (PMPGpp) acts as a chain terminator and competes with dGTP.Purified human telomera...


US Patent US10035814 (2018)

More data for this
Ligand-Target Pair
exvivo trap3 day assay


(Homo sapiens (human))
BDBM279802
PNG
(6-thio-G- phosphonate (6-S- PMPG), R form | US1003...)
Show SMILES CC(Cn1cnc2c1nc(N)[nH]c2=S)OCP(O)(O)=O
GoogleScholar
AffyNet 
UniChem
n/an/an/an/a 7.54E+3n/an/an/an/a



Geron Corporation

US Patent


Assay Description
Telomerase inhibition is observed in cells following the addition of the prodrugs (R)-PMPG-diisopropyloxy ester or (S)-PMPG-diisopropyloxy ester. HT3...


US Patent US10035814 (2018)

More data for this
Ligand-Target Pair
exvivo trap3 day assay


(Homo sapiens (human))
BDBM279805
PNG
(PMIBeG spermidine | US10035814, Compound 142873)
Show SMILES NCCCCNCCCNP(O)(=O)COCC(=C)Cn1cnc2c1nc(N)[nH]c2=O
GoogleScholar
AffyNet 
UniChem
n/an/an/an/a 6.70E+3n/an/an/an/a



Geron Corporation

US Patent


Assay Description
Telomerase inhibition is observed in cells following the addition of the prodrugs (R)-PMPG-diisopropyloxy ester or (S)-PMPG-diisopropyloxy ester. HT3...


US Patent US10035814 (2018)

More data for this
Ligand-Target Pair
Telomerase protein component 1


(Homo sapiens (human))
BDBM279799
PNG
(PMP(2)G | US10035814, Compound 142879)
Show SMILES CC(COCP(O)(=O)OP(O)(=O)OP(O)(O)=O)n1cnc2c1nc(N)[nH]c2=O
GoogleScholar
AffyNet 
UniChem
n/an/an/an/a 3.10E+3n/an/an/an/a



Geron Corporation

US Patent


Assay Description
(((Guanine-9-yl) propan-2-oxy) methyl) phosphonic acid diphosphate (PMPGpp) acts as a chain terminator and competes with dGTP.Purified human telomera...


US Patent US10035814 (2018)

More data for this
Ligand-Target Pair
exvivo trap3 day assay


(Homo sapiens (human))
BDBM279800
PNG
(PMPG free acid, R form | US10035814, Compound 1426...)
Show SMILES CC(Cn1cnc2c1nc(N)[nH]c2=O)OCP(O)(O)=O
GoogleScholar
AffyNet 
UniChem
n/an/an/an/a 1.17E+4n/an/an/an/a



Geron Corporation

US Patent


Assay Description
Telomerase inhibition is observed in cells following the addition of the prodrugs (R)-PMPG-diisopropyloxy ester or (S)-PMPG-diisopropyloxy ester. HT3...


US Patent US10035814 (2018)

More data for this
Ligand-Target Pair
exvivo trap3 day assay


(Homo sapiens (human))
BDBM279807
PNG
(PMPG-C10 amidate | US10035814, Compound 142962)
Show SMILES CCCCCCCCCCNP(O)(=O)COC(C)Cn1cnc2c1nc(N)[nH]c2=O
GoogleScholar
AffyNet 
UniChem
n/an/an/an/a 1.44E+3n/an/an/an/a



Geron Corporation

US Patent


Assay Description
Telomerase inhibition is observed in cells following the addition of the prodrugs (R)-PMPG-diisopropyloxy ester or (S)-PMPG-diisopropyloxy ester. HT3...


US Patent US10035814 (2018)

More data for this
Ligand-Target Pair
exvivo trap3 day assay


(Homo sapiens (human))
BDBM279806
PNG
(PMPG spermidine, R form | US10035814, Compound 142...)
Show SMILES CC(Cn1cnc2c1nc(N)[nH]c2=O)OCP(O)(=O)NCCCNCCCCN
GoogleScholar
AffyNet 
UniChem
n/an/an/an/a 5.00E+3n/an/an/an/a



Geron Corporation

US Patent


Assay Description
Telomerase inhibition is observed in cells following the addition of the prodrugs (R)-PMPG-diisopropyloxy ester or (S)-PMPG-diisopropyloxy ester. HT3...


US Patent US10035814 (2018)

More data for this
Ligand-Target Pair
Telomerase protein component 1


(Homo sapiens (human))
BDBM279793
PNG
(PMPG(lin) | US10035814, Compound 142848)
Show SMILES Nc1nc2n(CCCOCP(O)(=O)OP(O)(=O)OP(O)(O)=O)cnc2c(=O)[nH]1
GoogleScholar
AffyNet 
UniChem
n/an/an/an/a 1.50E+3n/an/an/an/a



Geron Corporation

US Patent


Assay Description
(((Guanine-9-yl) propan-2-oxy) methyl) phosphonic acid diphosphate (PMPGpp) acts as a chain terminator and competes with dGTP.Purified human telomera...


US Patent US10035814 (2018)

More data for this
Ligand-Target Pair
Telomerase protein component 1


(Homo sapiens (human))
BDBM279795
PNG
(PM(2)BG | US10035814, Compound 142915)
Show SMILES C[C@H](CCn1cnc2c1nc(N)[nH]c2=O)OCP(O)(=O)OP(O)(=O)OP(O)(O)=O
GoogleScholar
AffyNet 
UniChem
n/an/an/an/a>6.00E+4n/an/an/an/a



Geron Corporation

US Patent


Assay Description
(((Guanine-9-yl) propan-2-oxy) methyl) phosphonic acid diphosphate (PMPGpp) acts as a chain terminator and competes with dGTP.Purified human telomera...


US Patent US10035814 (2018)

More data for this
Ligand-Target Pair
Telomerase protein component 1


(Homo sapiens (human))
BDBM279798
PNG
(PMIBaG (mix R,S) | US10035814, Compound 142846)
Show SMILES CC(COCP(O)(=O)OP(O)(=O)OP(O)(O)=O)Cn1cnc2c1nc(N)[nH]c2=O
GoogleScholar
AffyNet 
UniChem
n/an/an/an/a 4.40E+3n/an/an/an/a



Geron Corporation

US Patent


Assay Description
(((Guanine-9-yl) propan-2-oxy) methyl) phosphonic acid diphosphate (PMPGpp) acts as a chain terminator and competes with dGTP.Purified human telomera...


US Patent US10035814 (2018)

More data for this
Ligand-Target Pair
exvivo trap3 day assay


(Homo sapiens (human))
BDBM279804
PNG
(PMPeG, prodrug | US10035814, Compound 142820)
Show SMILES CC(C)OC(=O)OCOP(=O)(COCC(=C)Cn1cnc2c1nc(N)[nH]c2=O)OCOC(=O)OC(C)C
GoogleScholar
AffyNet 
UniChem
n/an/an/an/a 1.09E+4n/an/an/an/a



Geron Corporation

US Patent


Assay Description
Telomerase inhibition is observed in cells following the addition of the prodrugs (R)-PMPG-diisopropyloxy ester or (S)-PMPG-diisopropyloxy ester. HT3...


US Patent US10035814 (2018)

More data for this
Ligand-Target Pair
Telomerase protein component 1


(Homo sapiens (human))
BDBM279797
PNG
(PMIBeG, free acid | US10035814, Compound 142810)
Show SMILES Nc1nc2n(CC(=C)COCP(O)(=O)OP(O)(=O)OP(O)(O)=O)cnc2c(=O)[nH]1
GoogleScholar
AffyNet 
UniChem
n/an/an/an/a 1.40E+3n/an/an/an/a



Geron Corporation

US Patent


Assay Description
(((Guanine-9-yl) propan-2-oxy) methyl) phosphonic acid diphosphate (PMPGpp) acts as a chain terminator and competes with dGTP.Purified human telomera...


US Patent US10035814 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%