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Patent code US10040788

Compile Data Set for Download or QSAR
Found 63 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM278409
PNG
((2S)-2-[3-(Difluoromethoxy)phenyl]-2-methoxy-N-[5-...)
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cccc(OC(F)F)c1
Show InChI InChI=1S/C20H21F2N7O3S/c1-31-16(12-4-2-5-14(10-12)32-18(21)22)17(30)25-20-28-27-19(33-20)24-13-7-9-29(11-13)15-6-3-8-23-26-15/h2-6,8,10,13,16,18H,7,9,11H2,1H3,(H,24,27)(H,25,28,30)/t13-,16+/m1/s1
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n/an/a 14.8n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10040788 (2018)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM278426
PNG
(US10040788, Example 18(a) | US10040788, Example 20...)
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccccc1
Show InChI InChI=1S/C19H21N7O2S/c1-28-16(13-6-3-2-4-7-13)17(27)22-19-25-24-18(29-19)21-14-9-11-26(12-14)15-8-5-10-20-23-15/h2-8,10,14,16H,9,11-12H2,1H3,(H,21,24)(H,22,25,27)/t14-,16+/m1/s1
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AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10040788 (2018)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM278426
PNG
(US10040788, Example 18(a) | US10040788, Example 20...)
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccccc1
Show InChI InChI=1S/C19H21N7O2S/c1-28-16(13-6-3-2-4-7-13)17(27)22-19-25-24-18(29-19)21-14-9-11-26(12-14)15-8-5-10-20-23-15/h2-8,10,14,16H,9,11-12H2,1H3,(H,21,24)(H,22,25,27)/t14-,16+/m1/s1
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AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10040788 (2018)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM278413
PNG
((2S)-2-Methoxy-N-[5-[[(3R)-1-pyridazin-3-ylpyrroli...)
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C20H20F3N7O3S/c1-32-16(12-4-2-5-14(10-12)33-20(21,22)23)17(31)26-19-29-28-18(34-19)25-13-7-9-30(11-13)15-6-3-8-24-27-15/h2-6,8,10,13,16H,7,9,11H2,1H3,(H,25,28)(H,26,29,31)/t13-,16+/m1/s1
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AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10040788 (2018)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM278450
PNG
(US10040788, Example 30(b))
Show SMILES CCO[C@H](C(=O)Nc1nnc(N[C@H]2CCN(C2)c2cccnn2)s1)c1cccc(OC)c1
Show InChI InChI=1S/C21H25N7O3S/c1-3-31-18(14-6-4-7-16(12-14)30-2)19(29)24-21-27-26-20(32-21)23-15-9-11-28(13-15)17-8-5-10-22-25-17/h4-8,10,12,15,18H,3,9,11,13H2,1-2H3,(H,23,26)(H,24,27,29)/t15-,18-/m0/s1
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AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10040788 (2018)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM278400
PNG
((2S)-2-Methoxy-2-phenyl-N-[5-[[(3R)-1-pyridazin-3-...)
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccccc1
Show InChI InChI=1S/C19H21N7O2S/c1-28-16(13-6-3-2-4-7-13)17(27)22-19-25-24-18(29-19)21-14-9-11-26(12-14)15-8-5-10-20-23-15/h2-8,10,14,16H,9,11-12H2,1H3,(H,21,24)(H,22,25,27)/t14-,16+/m1/s1
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AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10040788 (2018)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM278405
PNG
((2S)-2-Methoxy-2-(3-methoxyphenyl)-N-[5-[[(3R)-1-p...)
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cccc(OC)c1
Show InChI InChI=1S/C20H23N7O3S/c1-29-15-6-3-5-13(11-15)17(30-2)18(28)23-20-26-25-19(31-20)22-14-8-10-27(12-14)16-7-4-9-21-24-16/h3-7,9,11,14,17H,8,10,12H2,1-2H3,(H,22,25)(H,23,26,28)/t14-,17+/m1/s1
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AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10040788 (2018)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM278418
PNG
((2S)-2-(4-Fluorophenyl)-2-methoxy-N-[5-[[(3R)-1-py...)
Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccc(F)cc1
Show InChI InChI=1S/C19H20FN7O2S/c1-29-16(12-4-6-13(20)7-5-12)17(28)23-19-26-25-18(30-19)22-14-8-10-27(11-14)15-3-2-9-21-24-15/h2-7,9,14,16H,8,10-11H2,1H3,(H,22,25)(H,23,26,28)/t14-,16-/m1/s1
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AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10040788 (2018)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM278422
PNG
((2S)-2-(4-Fluoro-3-methoxy-phenyl)-2-methoxy-N-[5-...)
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccc(F)c(OC)c1
Show InChI InChI=1S/C20H22FN7O3S/c1-30-15-10-12(5-6-14(15)21)17(31-2)18(29)24-20-27-26-19(32-20)23-13-7-9-28(11-13)16-4-3-8-22-25-16/h3-6,8,10,13,17H,7,9,11H2,1-2H3,(H,23,26)(H,24,27,29)/t13-,17+/m1/s1
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AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10040788 (2018)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM278420
PNG
((2S)-2-Ethoxy-2-(4-fluorophenyl)-N-[5-[[(3R)-1-pyr...)
Show SMILES CCO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccc(F)cc1
Show InChI InChI=1S/C20H22FN7O2S/c1-2-30-17(13-5-7-14(21)8-6-13)18(29)24-20-27-26-19(31-20)23-15-9-11-28(12-15)16-4-3-10-22-25-16/h3-8,10,15,17H,2,9,11-12H2,1H3,(H,23,26)(H,24,27,29)/t15-,17-/m1/s1
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AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10040788 (2018)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM278410
PNG
((2R)-2-[3-(Difluoromethoxy)phenyl]-2-methoxy-N-[5-...)
Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cccc(OC(F)F)c1
Show InChI InChI=1S/C20H21F2N7O3S/c1-31-16(12-4-2-5-14(10-12)32-18(21)22)17(30)25-20-28-27-19(33-20)24-13-7-9-29(11-13)15-6-3-8-23-26-15/h2-6,8,10,13,16,18H,7,9,11H2,1H3,(H,24,27)(H,25,28,30)/t13-,16-/m1/s1
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AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10040788 (2018)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM278415
PNG
((2S)-2-Ethoxy-2-phenyl-N-[5-[[(3R)-1-pyridazin-3-y...)
Show SMILES CCO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccccc1
Show InChI InChI=1S/C20H23N7O2S/c1-2-29-17(14-7-4-3-5-8-14)18(28)23-20-26-25-19(30-20)22-15-10-12-27(13-15)16-9-6-11-21-24-16/h3-9,11,15,17H,2,10,12-13H2,1H3,(H,22,25)(H,23,26,28)/t15-,17+/m1/s1
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AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10040788 (2018)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM278436
PNG
(US10040788, Example 23(a))
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cncnn2)s1)c1cccc(OC(F)F)c1
Show InChI InChI=1S/C19H20F2N8O3S/c1-31-15(11-3-2-4-13(7-11)32-17(20)21)16(30)25-19-28-27-18(33-19)24-12-5-6-29(9-12)14-8-22-10-23-26-14/h2-4,7-8,10,12,15,17H,5-6,9H2,1H3,(H,24,27)(H,25,28,30)/t12-,15+/m1/s1
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AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10040788 (2018)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM50172181
PNG
(CHEMBL3810394 | US10040788, Example 3)
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cncnn2)s1)c1ccccc1
Show InChI InChI=1S/C18H20N8O2S/c1-28-15(12-5-3-2-4-6-12)16(27)22-18-25-24-17(29-18)21-13-7-8-26(10-13)14-9-19-11-20-23-14/h2-6,9,11,13,15H,7-8,10H2,1H3,(H,21,24)(H,22,25,27)/t13-,15+/m1/s1
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AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10040788 (2018)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM278411
PNG
((2S)-2-Methoxy-N-[5-[[(3R)-1-(1,2,4-triazin-3-yl)p...)
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2nccnn2)s1)c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C19H19F3N8O3S/c1-32-14(11-3-2-4-13(9-11)33-19(20,21)22)15(31)26-18-29-28-17(34-18)25-12-5-8-30(10-12)16-23-6-7-24-27-16/h2-4,6-7,9,12,14H,5,8,10H2,1H3,(H,25,28)(H,26,29,31)/t12-,14+/m1/s1
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AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10040788 (2018)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM50172239
PNG
(CHEMBL3809014 | US10040788, Example 11)
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccc(OC)cc1
Show InChI InChI=1S/C20H23N7O3S/c1-29-15-7-5-13(6-8-15)17(30-2)18(28)23-20-26-25-19(31-20)22-14-9-11-27(12-14)16-4-3-10-21-24-16/h3-8,10,14,17H,9,11-12H2,1-2H3,(H,22,25)(H,23,26,28)/t14-,17+/m1/s1
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AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10040788 (2018)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM278414
PNG
((2R)-2-Methoxy-N-[5-[[(3R)-1-pyridazin-3-ylpyrroli...)
Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C20H20F3N7O3S/c1-32-16(12-4-2-5-14(10-12)33-20(21,22)23)17(31)26-19-29-28-18(34-19)25-13-7-9-30(11-13)15-6-3-8-24-27-15/h2-6,8,10,13,16H,7,9,11H2,1H3,(H,25,28)(H,26,29,31)/t13-,16-/m1/s1
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AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10040788 (2018)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM278445
PNG
(US10040788, Example 28(a))
Show SMILES CCO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccc(OC)cc1
Show InChI InChI=1S/C21H25N7O3S/c1-3-31-18(14-6-8-16(30-2)9-7-14)19(29)24-21-27-26-20(32-21)23-15-10-12-28(13-15)17-5-4-11-22-25-17/h4-9,11,15,18H,3,10,12-13H2,1-2H3,(H,23,26)(H,24,27,29)/t15-,18-/m1/s1
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AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10040788 (2018)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM278439
PNG
(US10040788, Example 25(a))
Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccc(OC)c(OC)c1
Show InChI InChI=1S/C21H25N7O4S/c1-30-15-7-6-13(11-16(15)31-2)18(32-3)19(29)24-21-27-26-20(33-21)23-14-8-10-28(12-14)17-5-4-9-22-25-17/h4-7,9,11,14,18H,8,10,12H2,1-3H3,(H,23,26)(H,24,27,29)/t14-,18-/m1/s1
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n/an/a 35.4n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10040788 (2018)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM278403
PNG
((2S)-2-Methoxy-2-(3-methoxyphenyl)-N-[5-[[(3R)-1-(...)
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2nccnn2)s1)c1cccc(OC)c1
Show InChI InChI=1S/C19H22N8O3S/c1-29-14-5-3-4-12(10-14)15(30-2)16(28)23-19-26-25-18(31-19)22-13-6-9-27(11-13)17-20-7-8-21-24-17/h3-5,7-8,10,13,15H,6,9,11H2,1-2H3,(H,22,25)(H,23,26,28)/t13-,15+/m1/s1
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n/an/a 35.5n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10040788 (2018)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM278435
PNG
(US10040788, Example 22(b))
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@H]2CCN(C2)c2cncnn2)s1)c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C19H19F3N8O3S/c1-32-15(11-3-2-4-13(7-11)33-19(20,21)22)16(31)26-18-29-28-17(34-18)25-12-5-6-30(9-12)14-8-23-10-24-27-14/h2-4,7-8,10,12,15H,5-6,9H2,1H3,(H,25,28)(H,26,29,31)/t12-,15-/m0/s1
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n/an/a 43.4n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10040788 (2018)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM278433
PNG
(US10040788, Example 21(b))
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@H]2CCN(C2)c2cncnn2)s1)c1cccc(OC)c1
Show InChI InChI=1S/C19H22N8O3S/c1-29-14-5-3-4-12(8-14)16(30-2)17(28)23-19-26-25-18(31-19)22-13-6-7-27(10-13)15-9-20-11-21-24-15/h3-5,8-9,11,13,16H,6-7,10H2,1-2H3,(H,22,25)(H,23,26,28)/t13-,16-/m0/s1
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n/an/a 46.9n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10040788 (2018)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM278451
PNG
(US10040788, Example 31(a))
Show SMILES CCO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccc(F)c(OC)c1
Show InChI InChI=1S/C21H24FN7O3S/c1-3-32-18(13-6-7-15(22)16(11-13)31-2)19(30)25-21-28-27-20(33-21)24-14-8-10-29(12-14)17-5-4-9-23-26-17/h4-7,9,11,14,18H,3,8,10,12H2,1-2H3,(H,24,27)(H,25,28,30)/t14-,18-/m1/s1
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n/an/a 50.2n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10040788 (2018)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM278455
PNG
(US10040788, Example 33(a))
Show SMILES CCO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2nccnn2)s1)c1ccc(F)c(OC)c1
Show InChI InChI=1S/C20H23FN8O3S/c1-3-32-16(12-4-5-14(21)15(10-12)31-2)17(30)25-20-28-27-19(33-20)24-13-6-9-29(11-13)18-22-7-8-23-26-18/h4-5,7-8,10,13,16H,3,6,9,11H2,1-2H3,(H,24,27)(H,25,28,30)/t13-,16-/m1/s1
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n/an/a 50.2n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10040788 (2018)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM278443
PNG
(US10040788, Example 27(a))
Show SMILES CCO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2nccnn2)s1)c1cccc(OC)c1
Show InChI InChI=1S/C20H24N8O3S/c1-3-31-16(13-5-4-6-15(11-13)30-2)17(29)24-20-27-26-19(32-20)23-14-7-10-28(12-14)18-21-8-9-22-25-18/h4-6,8-9,11,14,16H,3,7,10,12H2,1-2H3,(H,23,26)(H,24,27,29)/t14-,16-/m1/s1
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n/an/a 50.8n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10040788 (2018)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM50172138
PNG
(CHEMBL3808443 | US10040788, Example 1(a))
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2nccnn2)s1)c1ccccc1
Show InChI InChI=1S/C18H20N8O2S/c1-28-14(12-5-3-2-4-6-12)15(27)22-18-25-24-17(29-18)21-13-7-10-26(11-13)16-19-8-9-20-23-16/h2-6,8-9,13-14H,7,10-11H2,1H3,(H,21,24)(H,22,25,27)/t13-,14+/m1/s1
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n/an/a 62.8n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10040788 (2018)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM278454
PNG
(US10040788, Example 32(b))
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@H]2CCN(C2)c2nccnn2)s1)c1ccc(F)c(OC)c1
Show InChI InChI=1S/C19H21FN8O3S/c1-30-14-9-11(3-4-13(14)20)15(31-2)16(29)24-19-27-26-18(32-19)23-12-5-8-28(10-12)17-21-6-7-22-25-17/h3-4,6-7,9,12,15H,5,8,10H2,1-2H3,(H,23,26)(H,24,27,29)/t12-,15-/m0/s1
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n/an/a 70.7n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10040788 (2018)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM278434
PNG
(US10040788, Example 22(a))
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cncnn2)s1)c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C19H19F3N8O3S/c1-32-15(11-3-2-4-13(7-11)33-19(20,21)22)16(31)26-18-29-28-17(34-18)25-12-5-6-30(9-12)14-8-23-10-24-27-14/h2-4,7-8,10,12,15H,5-6,9H2,1H3,(H,25,28)(H,26,29,31)/t12-,15+/m1/s1
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n/an/a 72.9n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10040788 (2018)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM278438
PNG
((2S)-2-methoxy-2-(4- methoxyphenyl)-N-[5-[[(3R)- 1...)
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2nccnn2)s1)c1ccc(OC)cc1
Show InChI InChI=1S/C19H22N8O3S/c1-29-14-5-3-12(4-6-14)15(30-2)16(28)23-19-26-25-18(31-19)22-13-7-10-27(11-13)17-20-8-9-21-24-17/h3-6,8-9,13,15H,7,10-11H2,1-2H3,(H,22,25)(H,23,26,28)/t13-,15+/m1/s1
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n/an/a 74.7n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10040788 (2018)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM278446
PNG
(US10040788, Example 28(b))
Show SMILES CCO[C@H](C(=O)Nc1nnc(N[C@H]2CCN(C2)c2cccnn2)s1)c1ccc(OC)cc1
Show InChI InChI=1S/C21H25N7O3S/c1-3-31-18(14-6-8-16(30-2)9-7-14)19(29)24-21-27-26-20(32-21)23-15-10-12-28(13-15)17-5-4-11-22-25-17/h4-9,11,15,18H,3,10,12-13H2,1-2H3,(H,23,26)(H,24,27,29)/t15-,18-/m0/s1
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n/an/a 84.8n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10040788 (2018)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM278428
PNG
(US10040788, Example 19(a))
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2nccnn2)s1)c1cccc(OC(F)F)c1
Show InChI InChI=1S/C19H20F2N8O3S/c1-31-14(11-3-2-4-13(9-11)32-16(20)21)15(30)25-19-28-27-18(33-19)24-12-5-8-29(10-12)17-22-6-7-23-26-17/h2-4,6-7,9,12,14,16H,5,8,10H2,1H3,(H,24,27)(H,25,28,30)/t12-,14+/m1/s1
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n/an/a 85.1n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10040788 (2018)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM278407
PNG
((2S)-2-[3-(Difluoromethoxy)phenyl]-2-methoxy-N-[5-...)
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2nccnn2)s1)c1cccc(OC(F)F)c1
Show InChI InChI=1S/C19H20F2N8O3S/c1-31-14(11-3-2-4-13(9-11)32-16(20)21)15(30)25-19-28-27-18(33-19)24-12-5-8-29(10-12)17-22-6-7-23-26-17/h2-4,6-7,9,12,14,16H,5,8,10H2,1H3,(H,24,27)(H,25,28,30)/t12-,14+/m1/s1
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n/an/a 85.1n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10040788 (2018)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM278452
PNG
(US10040788, Example 31(b))
Show SMILES CCO[C@H](C(=O)Nc1nnc(N[C@H]2CCN(C2)c2cccnn2)s1)c1ccc(F)c(OC)c1
Show InChI InChI=1S/C21H24FN7O3S/c1-3-32-18(13-6-7-15(22)16(11-13)31-2)19(30)25-21-28-27-20(33-21)24-14-8-10-29(12-14)17-5-4-9-23-26-17/h4-7,9,11,14,18H,3,8,10,12H2,1-2H3,(H,24,27)(H,25,28,30)/t14-,18-/m0/s1
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n/an/a 86.2n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10040788 (2018)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM278442
PNG
(US10040788, Example 26(b))
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@H]2CCN(C2)c2nccnn2)s1)c1ccc(OC)c(OC)c1
Show InChI InChI=1S/C20H24N8O4S/c1-30-14-5-4-12(10-15(14)31-2)16(32-3)17(29)24-20-27-26-19(33-20)23-13-6-9-28(11-13)18-21-7-8-22-25-18/h4-5,7-8,10,13,16H,6,9,11H2,1-3H3,(H,23,26)(H,24,27,29)/t13-,16-/m0/s1
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n/an/a 87.7n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10040788 (2018)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM278406
PNG
((2R)-2-Methoxy-2-(3-methoxyphenyl)-N-[5-[[(3R)-1-p...)
Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cccc(OC)c1
Show InChI InChI=1S/C20H23N7O3S/c1-29-15-6-3-5-13(11-15)17(30-2)18(28)23-20-26-25-19(31-20)22-14-8-10-27(12-14)16-7-4-9-21-24-16/h3-7,9,11,14,17H,8,10,12H2,1-2H3,(H,22,25)(H,23,26,28)/t14-,17-/m1/s1
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AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10040788 (2018)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM278457
PNG
(US10040788, Example 34(a))
Show SMILES CCO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2nccnn2)s1)c1ccccc1
Show InChI InChI=1S/C19H22N8O2S/c1-2-29-15(13-6-4-3-5-7-13)16(28)23-19-26-25-18(30-19)22-14-8-11-27(12-14)17-20-9-10-21-24-17/h3-7,9-10,14-15H,2,8,11-12H2,1H3,(H,22,25)(H,23,26,28)/t14-,15-/m1/s1
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AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10040788 (2018)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM278425
PNG
(US10040788, Example 17(b))
Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2nccnn2)s1)c1ccc(F)cc1
Show InChI InChI=1S/C18H19FN8O2S/c1-29-14(11-2-4-12(19)5-3-11)15(28)23-18-26-25-17(30-18)22-13-6-9-27(10-13)16-20-7-8-21-24-16/h2-5,7-8,13-14H,6,9-10H2,1H3,(H,22,25)(H,23,26,28)/t13-,14-/m1/s1
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AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10040788 (2018)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM278449
PNG
(US10040788, Example 30(a))
Show SMILES CCO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cccc(OC)c1
Show InChI InChI=1S/C21H25N7O3S/c1-3-31-18(14-6-4-7-16(12-14)30-2)19(29)24-21-27-26-20(32-21)23-15-9-11-28(13-15)17-8-5-10-22-25-17/h4-8,10,12,15,18H,3,9,11,13H2,1-2H3,(H,23,26)(H,24,27,29)/t15-,18-/m1/s1
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AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10040788 (2018)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM278418
PNG
((2S)-2-(4-Fluorophenyl)-2-methoxy-N-[5-[[(3R)-1-py...)
Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccc(F)cc1
Show InChI InChI=1S/C19H20FN7O2S/c1-29-16(12-4-6-13(20)7-5-12)17(28)23-19-26-25-18(30-19)22-14-8-10-27(11-14)15-3-2-9-21-24-15/h2-7,9,14,16H,8,10-11H2,1H3,(H,22,25)(H,23,26,28)/t14-,16-/m1/s1
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n/an/a 102n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10040788 (2018)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM278427
PNG
(US10040788, Example 18(b) | US10040788, Example 20...)
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@H]2CCN(C2)c2cccnn2)s1)c1ccccc1
Show InChI InChI=1S/C19H21N7O2S/c1-28-16(13-6-3-2-4-7-13)17(27)22-19-25-24-18(29-19)21-14-9-11-26(12-14)15-8-5-10-20-23-15/h2-8,10,14,16H,9,11-12H2,1H3,(H,21,24)(H,22,25,27)/t14-,16-/m0/s1
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n/an/a 107n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10040788 (2018)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM278447
PNG
(US10040788, Example 29(a))
Show SMILES CCO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2nccnn2)s1)c1ccc(OC)cc1
Show InChI InChI=1S/C20H24N8O3S/c1-3-31-16(13-4-6-15(30-2)7-5-13)17(29)24-20-27-26-19(32-20)23-14-8-11-28(12-14)18-21-9-10-22-25-18/h4-7,9-10,14,16H,3,8,11-12H2,1-2H3,(H,23,26)(H,24,27,29)/t14-,16-/m1/s1
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n/an/a 108n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10040788 (2018)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM278416
PNG
((2R)-2-Ethoxy-2-phenyl-N-[5-[[(3R)-1-pyridazin-3-y...)
Show SMILES CCO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccccc1
Show InChI InChI=1S/C20H23N7O2S/c1-2-29-17(14-7-4-3-5-8-14)18(28)23-20-26-25-19(30-20)22-15-10-12-27(13-15)16-9-6-11-21-24-16/h3-9,11,15,17H,2,10,12-13H2,1H3,(H,22,25)(H,23,26,28)/t15-,17-/m1/s1
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n/an/a 110n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10040788 (2018)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM278427
PNG
(US10040788, Example 18(b) | US10040788, Example 20...)
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@H]2CCN(C2)c2cccnn2)s1)c1ccccc1
Show InChI InChI=1S/C19H21N7O2S/c1-28-16(13-6-3-2-4-7-13)17(27)22-19-25-24-18(29-19)21-14-9-11-26(12-14)15-8-5-10-20-23-15/h2-8,10,14,16H,9,11-12H2,1H3,(H,21,24)(H,22,25,27)/t14-,16-/m0/s1
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n/an/a 119n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10040788 (2018)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM278440
PNG
(US10040788, Example 25(b))
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@H]2CCN(C2)c2cccnn2)s1)c1ccc(OC)c(OC)c1
Show InChI InChI=1S/C21H25N7O4S/c1-30-15-7-6-13(11-16(15)31-2)18(32-3)19(29)24-21-27-26-20(33-21)23-14-8-10-28(12-14)17-5-4-9-22-25-17/h4-7,9,11,14,18H,8,10,12H2,1-3H3,(H,23,26)(H,24,27,29)/t14-,18-/m0/s1
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n/an/a 135n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10040788 (2018)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM278401
PNG
((2R)-2-Methoxy-2-phenyl-N-[5-[[(3R)-1-pyridazin-3-...)
Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccccc1
Show InChI InChI=1S/C19H21N7O2S/c1-28-16(13-6-3-2-4-7-13)17(27)22-19-25-24-18(29-19)21-14-9-11-26(12-14)15-8-5-10-20-23-15/h2-8,10,14,16H,9,11-12H2,1H3,(H,21,24)(H,22,25,27)/t14-,16-/m1/s1
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n/an/a 147n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10040788 (2018)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM278460
PNG
(US10040788, Example 35(b))
Show SMILES CCO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2nccnn2)s1)c1ccc(F)cc1
Show InChI InChI=1S/C19H21FN8O2S/c1-2-30-15(12-3-5-13(20)6-4-12)16(29)24-19-27-26-18(31-19)23-14-7-10-28(11-14)17-21-8-9-22-25-17/h3-6,8-9,14-15H,2,7,10-11H2,1H3,(H,23,26)(H,24,27,29)/t14-,15+/m1/s1
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n/an/a 155n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10040788 (2018)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM278437
PNG
(US10040788, Example 23(b))
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@H]2CCN(C2)c2cncnn2)s1)c1cccc(OC(F)F)c1
Show InChI InChI=1S/C19H20F2N8O3S/c1-31-15(11-3-2-4-13(7-11)32-17(20)21)16(30)25-19-28-27-18(33-19)24-12-5-6-29(9-12)14-8-22-10-23-26-14/h2-4,7-8,10,12,15,17H,5-6,9H2,1H3,(H,24,27)(H,25,28,30)/t12-,15-/m0/s1
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n/an/a 162n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10040788 (2018)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM278432
PNG
(US10040788, Example 21(a))
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cncnn2)s1)c1cccc(OC)c1
Show InChI InChI=1S/C19H22N8O3S/c1-29-14-5-3-4-12(8-14)16(30-2)17(28)23-19-26-25-18(31-19)22-13-6-7-27(10-13)15-9-20-11-21-24-15/h3-5,8-9,11,13,16H,6-7,10H2,1-2H3,(H,22,25)(H,23,26,28)/t13-,16+/m1/s1
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n/an/a 162n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10040788 (2018)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM278423
PNG
((2R)-2-(4-Fluoro-3-methoxy-phenyl)-2-methoxy-N-[5-...)
Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccc(F)c(OC)c1
Show InChI InChI=1S/C20H22FN7O3S/c1-30-15-10-12(5-6-14(15)21)17(31-2)18(29)24-20-27-26-19(32-20)23-13-7-9-28(11-13)16-4-3-8-22-25-16/h3-6,8,10,13,17H,7,9,11H2,1-2H3,(H,23,26)(H,24,27,29)/t13-,17-/m1/s1
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n/an/a 168n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10040788 (2018)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM278420
PNG
((2S)-2-Ethoxy-2-(4-fluorophenyl)-N-[5-[[(3R)-1-pyr...)
Show SMILES CCO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccc(F)cc1
Show InChI InChI=1S/C20H22FN7O2S/c1-2-30-17(13-5-7-14(21)8-6-13)18(29)24-20-27-26-19(31-20)23-15-9-11-28(12-15)16-4-3-10-22-25-16/h3-8,10,15,17H,2,9,11-12H2,1H3,(H,23,26)(H,24,27,29)/t15-,17-/m1/s1
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n/an/a 170n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10040788 (2018)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM278412
PNG
((2R)-2-Methoxy-N-[5-[[(3R)-1-(1,2,4-triazin-3-yl)p...)
Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2nccnn2)s1)c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C19H19F3N8O3S/c1-32-14(11-3-2-4-13(9-11)33-19(20,21)22)15(31)26-18-29-28-17(34-18)25-12-5-8-30(10-12)16-23-6-7-24-27-16/h2-4,6-7,9,12,14H,5,8,10H2,1H3,(H,25,28)(H,26,29,31)/t12-,14-/m1/s1
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n/an/a 221n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10040788 (2018)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM278408
PNG
((2R)-2-[3-(Difluoromethoxy)phenyl]-2-methoxy-N-[5-...)
Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2nccnn2)s1)c1cccc(OC(F)F)c1
Show InChI InChI=1S/C19H20F2N8O3S/c1-31-14(11-3-2-4-13(9-11)32-16(20)21)15(30)25-19-28-27-18(33-19)24-12-5-8-29(10-12)17-22-6-7-23-26-17/h2-4,6-7,9,12,14,16H,5,8,10H2,1H3,(H,24,27)(H,25,28,30)/t12-,14-/m1/s1
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n/an/a 519n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10040788 (2018)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM278429
PNG
(US10040788, Example 19(b))
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@H]2CCN(C2)c2nccnn2)s1)c1cccc(OC(F)F)c1
Show InChI InChI=1S/C19H20F2N8O3S/c1-31-14(11-3-2-4-13(9-11)32-16(20)21)15(30)25-19-28-27-18(33-19)24-12-5-8-29(10-12)17-22-6-7-23-26-17/h2-4,6-7,9,12,14,16H,5,8,10H2,1H3,(H,24,27)(H,25,28,30)/t12-,14-/m0/s1
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n/an/a 519n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10040788 (2018)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM278444
PNG
(US10040788, Example 27(b))
Show SMILES CCO[C@H](C(=O)Nc1nnc(N[C@H]2CCN(C2)c2nccnn2)s1)c1cccc(OC)c1
Show InChI InChI=1S/C20H24N8O3S/c1-3-31-16(13-5-4-6-15(11-13)30-2)17(29)24-20-27-26-19(32-20)23-14-7-10-28(12-14)18-21-8-9-22-25-18/h4-6,8-9,11,14,16H,3,7,10,12H2,1-2H3,(H,23,26)(H,24,27,29)/t14-,16-/m0/s1
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n/an/a 844n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10040788 (2018)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM278404
PNG
((2R)-2-Methoxy-2-(3-methoxyphenyl)-N-[5-[[(3R)-1-(...)
Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2nccnn2)s1)c1cccc(OC)c1
Show InChI InChI=1S/C19H22N8O3S/c1-29-14-5-3-4-12(10-14)15(30-2)16(28)23-19-26-25-18(31-19)22-13-6-9-27(11-13)17-20-7-8-21-24-17/h3-5,7-8,10,13,15H,6,9,11H2,1-2H3,(H,22,25)(H,23,26,28)/t13-,15-/m1/s1
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n/an/a 908n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10040788 (2018)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM278448
PNG
(US10040788, Example 29(b))
Show SMILES CCO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2nccnn2)s1)c1ccc(OC)cc1
Show InChI InChI=1S/C20H24N8O3S/c1-3-31-16(13-4-6-15(30-2)7-5-13)17(29)24-20-27-26-19(32-20)23-14-8-11-28(12-14)18-21-9-10-22-25-18/h4-7,9-10,14,16H,3,8,11-12H2,1-2H3,(H,23,26)(H,24,27,29)/t14-,16+/m1/s1
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n/an/a 1.37E+3n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10040788 (2018)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM278458
PNG
(US10040788, Example 34(b))
Show SMILES CCO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2nccnn2)s1)c1ccccc1
Show InChI InChI=1S/C19H22N8O2S/c1-2-29-15(13-6-4-3-5-7-13)16(28)23-19-26-25-18(30-19)22-14-8-11-27(12-14)17-20-9-10-21-24-17/h3-7,9-10,14-15H,2,8,11-12H2,1H3,(H,22,25)(H,23,26,28)/t14-,15+/m1/s1
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n/an/a 1.48E+3n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10040788 (2018)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM278399
PNG
((2R)-2-Methoxy-2-phenyl-N-[5-[[(3R)-1-(1,2,4-triaz...)
Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2nccnn2)s1)c1ccccc1
Show InChI InChI=1S/C18H20N8O2S/c1-28-14(12-5-3-2-4-6-12)15(27)22-18-25-24-17(29-18)21-13-7-10-26(11-13)16-19-8-9-20-23-16/h2-6,8-9,13-14H,7,10-11H2,1H3,(H,21,24)(H,22,25,27)/t13-,14-/m1/s1
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n/an/a 1.70E+3n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10040788 (2018)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM278459
PNG
(US10040788, Example 35(a))
Show SMILES CCO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2nccnn2)s1)c1ccc(F)cc1
Show InChI InChI=1S/C19H21FN8O2S/c1-2-30-15(12-3-5-13(20)6-4-12)16(29)24-19-27-26-18(31-19)23-14-7-10-28(11-14)17-21-8-9-22-25-17/h3-6,8-9,14-15H,2,7,10-11H2,1H3,(H,23,26)(H,24,27,29)/t14-,15-/m1/s1
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n/an/a 1.95E+3n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10040788 (2018)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM278456
PNG
(US10040788, Example 33(b))
Show SMILES CCO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2nccnn2)s1)c1ccc(F)c(OC)c1
Show InChI InChI=1S/C20H23FN8O3S/c1-3-32-16(12-4-5-14(21)15(10-12)31-2)17(30)25-20-28-27-19(33-20)24-13-6-9-29(11-13)18-22-7-8-23-26-18/h4-5,7-8,10,13,16H,3,6,9,11H2,1-2H3,(H,24,27)(H,25,28,30)/t13-,16+/m1/s1
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n/an/a 1.97E+3n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10040788 (2018)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM50172240
PNG
(CHEMBL3808882 | US10040788, Example 17(a))
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2nccnn2)s1)c1ccc(F)cc1
Show InChI InChI=1S/C18H19FN8O2S/c1-29-14(11-2-4-12(19)5-3-11)15(28)23-18-26-25-17(30-18)22-13-6-9-27(10-13)16-20-7-8-21-24-16/h2-5,7-8,13-14H,6,9-10H2,1H3,(H,22,25)(H,23,26,28)/t13-,14+/m1/s1
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PC cid
PC sid
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n/an/a 2.19E+3n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10040788 (2018)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM278441
PNG
(US10040788, Example 26(a))
Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2nccnn2)s1)c1ccc(OC)c(OC)c1
Show InChI InChI=1S/C20H24N8O4S/c1-30-14-5-4-12(10-15(14)31-2)16(32-3)17(29)24-20-27-26-19(33-20)23-13-6-9-28(11-13)18-21-7-8-22-25-18/h4-5,7-8,10,13,16H,6,9,11H2,1-3H3,(H,23,26)(H,24,27,29)/t13-,16-/m1/s1
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n/an/a 2.27E+3n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10040788 (2018)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM278453
PNG
(US10040788, Example 32(a))
Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2nccnn2)s1)c1ccc(F)c(OC)c1
Show InChI InChI=1S/C19H21FN8O3S/c1-30-14-9-11(3-4-13(14)20)15(31-2)16(29)24-19-27-26-18(32-19)23-12-5-8-28(10-12)17-21-6-7-22-25-17/h3-4,6-7,9,12,15H,5,8,10H2,1-2H3,(H,23,26)(H,24,27,29)/t12-,15-/m1/s1
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n/an/a 2.46E+3n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10040788 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%