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Patent code US10040790

Compile Data Set for Download or QSAR
Found 162 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM278486
PNG
(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-8-eth...)
Show SMILES CCc1c(N)ncc2CN(C(=O)N(C)c12)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C18H20F2N4O3/c1-5-10-15-9(7-22-17(10)21)8-24(18(25)23(15)2)16-13(19)11(26-3)6-12(27-4)14(16)20/h6-7H,5,8H2,1-4H3,(H2,21,22)
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Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM278487
PNG
(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-met...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(C#N)c3N(C)C2=O)c1F
Show InChI InChI=1S/C17H15F2N5O3/c1-23-14-8(6-22-16(21)9(14)5-20)7-24(17(23)25)15-12(18)10(26-2)4-11(27-3)13(15)19/h4,6H,7H2,1-3H3,(H2,21,22)
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Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM278488
PNG
(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-8-eth...)
Show SMILES CCOc1c(N)ncc2CN(C(=O)N(C)c12)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C18H20F2N4O4/c1-5-28-16-14-9(7-22-17(16)21)8-24(18(25)23(14)2)15-12(19)10(26-3)6-11(27-4)13(15)20/h6-7H,5,8H2,1-4H3,(H2,21,22)
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Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM278489
PNG
(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-8-(2-...)
Show SMILES COCCOc1c(N)ncc2CN(C(=O)N(C)c12)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C19H22F2N4O5/c1-24-15-10(8-23-18(22)17(15)30-6-5-27-2)9-25(19(24)26)16-13(20)11(28-3)7-12(29-4)14(16)21/h7-8H,5-6,9H2,1-4H3,(H2,22,23)
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Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM278491
PNG
(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-met...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(Oc4ccccc4)c3N(C)C2=O)c1F
Show InChI InChI=1S/C22H20F2N4O4/c1-27-18-12(10-26-21(25)20(18)32-13-7-5-4-6-8-13)11-28(22(27)29)19-16(23)14(30-2)9-15(31-3)17(19)24/h4-10H,11H2,1-3H3,(H2,25,26)
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Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM278496
PNG
(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-met...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(-c4cn[nH]c4)c3N(C)C2=O)c1F
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM278497
PNG
(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-met...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(-c4ccnn4C)c3N(C)C2=O)c1F
Show InChI InChI=1S/C20H20F2N6O3/c1-26-17-10(8-24-19(23)14(17)11-5-6-25-27(11)2)9-28(20(26)29)18-15(21)12(30-3)7-13(31-4)16(18)22/h5-8H,9H2,1-4H3,(H2,23,24)
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Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM278497
PNG
(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-met...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(-c4ccnn4C)c3N(C)C2=O)c1F
Show InChI InChI=1S/C20H20F2N6O3/c1-26-17-10(8-24-19(23)14(17)11-5-6-25-27(11)2)9-28(20(26)29)18-15(21)12(30-3)7-13(31-4)16(18)22/h5-8H,9H2,1-4H3,(H2,23,24)
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Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM278499
PNG
(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-8-(4-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(-c4ccc(F)cc4)c3N(C)C2=O)c1F
Show InChI InChI=1S/C22H19F3N4O3/c1-28-19-12(9-27-21(26)16(19)11-4-6-13(23)7-5-11)10-29(22(28)30)20-17(24)14(31-2)8-15(32-3)18(20)25/h4-9H,10H2,1-3H3,(H2,26,27)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM278500
PNG
(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-met...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(-c4cccnc4)c3N(C)C2=O)c1F
Show InChI InChI=1S/C21H19F2N5O3/c1-27-18-12(9-26-20(24)15(18)11-5-4-6-25-8-11)10-28(21(27)29)19-16(22)13(30-2)7-14(31-3)17(19)23/h4-9H,10H2,1-3H3,(H2,24,26)
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Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM278502
PNG
(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-met...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(\C=C\c4ccccc4)c3N(C)C2=O)c1F
Show InChI InChI=1S/C24H22F2N4O3/c1-29-21-15(12-28-23(27)16(21)10-9-14-7-5-4-6-8-14)13-30(24(29)31)22-19(25)17(32-2)11-18(33-3)20(22)26/h4-12H,13H2,1-3H3,(H2,27,28)/b10-9+
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Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM278505
PNG
(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-8-(3,...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(C4=CCOCC4)c3N(C)C2=O)c1F
Show InChI InChI=1S/C21H22F2N4O4/c1-26-18-12(9-25-20(24)15(18)11-4-6-31-7-5-11)10-27(21(26)28)19-16(22)13(29-2)8-14(30-3)17(19)23/h4,8-9H,5-7,10H2,1-3H3,(H2,24,25)
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Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM278509
PNG
(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-6'-(methylam...)
Show SMILES CNc1cc2c(CN(C(=O)C22CC2)c2c(F)c(OC)cc(OC)c2F)cn1
Show InChI InChI=1S/C19H19F2N3O3/c1-22-14-6-11-10(8-23-14)9-24(18(25)19(11)4-5-19)17-15(20)12(26-2)7-13(27-3)16(17)21/h6-8H,4-5,9H2,1-3H3,(H,22,23)
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Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM278510
PNG
(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-6'-(tetrahyd...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(NC4CCOCC4)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C23H25F2N3O4/c1-30-16-10-17(31-2)20(25)21(19(16)24)28-12-13-11-26-18(27-14-3-7-32-8-4-14)9-15(13)23(5-6-23)22(28)29/h9-11,14H,3-8,12H2,1-2H3,(H,26,27)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM278512
PNG
(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-6'-(pyridin-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(NCc4ccccn4)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C24H22F2N4O3/c1-32-17-10-18(33-2)21(26)22(20(17)25)30-13-14-11-28-19(29-12-15-5-3-4-8-27-15)9-16(14)24(6-7-24)23(30)31/h3-5,8-11H,6-7,12-13H2,1-2H3,(H,28,29)
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Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM278513
PNG
((S)-2'-(2,6-difluoro-3,5-dimethoxyphenyl)-6'-(tetr...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(NC4CCOC4)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C22H23F2N3O4/c1-29-15-8-16(30-2)19(24)20(18(15)23)27-10-12-9-25-17(26-13-3-6-31-11-13)7-14(12)22(4-5-22)21(27)28/h7-9,13H,3-6,10-11H2,1-2H3,(H,25,26)
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US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM278514
PNG
(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-6'-(2-(4-met...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(NCCN4CCN(C)CC4)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C25H31F2N5O3/c1-30-8-10-31(11-9-30)7-6-28-20-12-17-16(14-29-20)15-32(24(33)25(17)4-5-25)23-21(26)18(34-2)13-19(35-3)22(23)27/h12-14H,4-11,15H2,1-3H3,(H,28,29)
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US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM278515
PNG
(US10040790, Example 31 | methyl 2'-(2,6-difluoro-3...)
Show SMILES COC(=O)Nc1cc2c(CN(C(=O)C22CC2)c2c(F)c(OC)cc(OC)c2F)cn1
Show InChI InChI=1S/C20H19F2N3O5/c1-28-12-7-13(29-2)16(22)17(15(12)21)25-9-10-8-23-14(24-19(27)30-3)6-11(10)20(4-5-20)18(25)26/h6-8H,4-5,9H2,1-3H3,(H,23,24,27)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM278517
PNG
(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-6'-(3-fluoro...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4cccc(F)c4)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C24H20F3N3O3/c1-32-17-10-18(33-2)21(27)22(20(17)26)30-12-13-11-28-19(29-15-5-3-4-14(25)8-15)9-16(13)24(6-7-24)23(30)31/h3-5,8-11H,6-7,12H2,1-2H3,(H,28,29)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM278526
PNG
(6'-(cyclobutylamino)-2'-(2,6-difluoro-3,5-dimethox...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(NC4CCC4)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C22H23F2N3O3/c1-29-15-9-16(30-2)19(24)20(18(15)23)27-11-12-10-25-17(26-13-4-3-5-13)8-14(12)22(6-7-22)21(27)28/h8-10,13H,3-7,11H2,1-2H3,(H,25,26)
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Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM278527
PNG
(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-6'-(3,3-difl...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(NC4CC(F)(F)C4)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C22H21F4N3O3/c1-31-14-6-15(32-2)18(24)19(17(14)23)29-10-11-9-27-16(28-12-7-22(25,26)8-12)5-13(11)21(3-4-21)20(29)30/h5-6,9,12H,3-4,7-8,10H2,1-2H3,(H,27,28)
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Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM278531
PNG
(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-8-met...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(C)c3N(Cc3cnn(C)c3)C2=O)c1F
Show InChI InChI=1S/C21H22F2N6O3/c1-11-18-13(7-25-20(11)24)10-29(21(30)28(18)9-12-6-26-27(2)8-12)19-16(22)14(31-3)5-15(32-4)17(19)23/h5-8H,9-10H2,1-4H3,(H2,24,25)
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Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM278533
PNG
(7-amino-1-(cyclopropylmethyl)-3-(2,6-difluoro-3,5-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(C#N)c3N(CC3CC3)C2=O)c1F
Show InChI InChI=1S/C20H19F2N5O3/c1-29-13-5-14(30-2)16(22)18(15(13)21)27-9-11-7-25-19(24)12(6-23)17(11)26(20(27)28)8-10-3-4-10/h5,7,10H,3-4,8-9H2,1-2H3,(H2,24,25)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM278536
PNG
(7-amino-1-(3,5-difluorobenzyl)-3-(2,6-difluoro-3,5...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(C#N)c3N(Cc3cc(F)cc(F)c3)C2=O)c1F
Show InChI InChI=1S/C23H17F4N5O3/c1-34-16-6-17(35-2)19(27)21(18(16)26)32-10-12-8-30-22(29)15(7-28)20(12)31(23(32)33)9-11-3-13(24)5-14(25)4-11/h3-6,8H,9-10H2,1-2H3,(H2,29,30)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM278536
PNG
(7-amino-1-(3,5-difluorobenzyl)-3-(2,6-difluoro-3,5...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(C#N)c3N(Cc3cc(F)cc(F)c3)C2=O)c1F
Show InChI InChI=1S/C23H17F4N5O3/c1-34-16-6-17(35-2)19(27)21(18(16)26)32-10-12-8-30-22(29)15(7-28)20(12)31(23(32)33)9-11-3-13(24)5-14(25)4-11/h3-6,8H,9-10H2,1-2H3,(H2,29,30)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM278487
PNG
(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-met...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(C#N)c3N(C)C2=O)c1F
Show InChI InChI=1S/C17H15F2N5O3/c1-23-14-8(6-22-16(21)9(14)5-20)7-24(17(23)25)15-12(18)10(26-2)4-11(27-3)13(15)19/h4,6H,7H2,1-3H3,(H2,21,22)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM278491
PNG
(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-met...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(Oc4ccccc4)c3N(C)C2=O)c1F
Show InChI InChI=1S/C22H20F2N4O4/c1-27-18-12(10-26-21(25)20(18)32-13-7-5-4-6-8-13)11-28(22(27)29)19-16(23)14(30-2)9-15(31-3)17(19)24/h4-10H,11H2,1-3H3,(H2,25,26)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM278492
PNG
(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-met...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(-c4cnn(C)c4)c3N(C)C2=O)c1F
Show InChI InChI=1S/C20H20F2N6O3/c1-26-8-10(7-25-26)14-17-11(6-24-19(14)23)9-28(20(29)27(17)2)18-15(21)12(30-3)5-13(31-4)16(18)22/h5-8H,9H2,1-4H3,(H2,23,24)
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Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM278493
PNG
(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-met...)
Show SMILES CCn1cc(cn1)-c1c(N)ncc2CN(C(=O)N(C)c12)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C21H22F2N6O3/c1-5-28-9-11(8-26-28)15-18-12(7-25-20(15)24)10-29(21(30)27(18)2)19-16(22)13(31-3)6-14(32-4)17(19)23/h6-9H,5,10H2,1-4H3,(H2,24,25)
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Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM278498
PNG
(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-met...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(-c4ccccc4)c3N(C)C2=O)c1F
Show InChI InChI=1S/C22H20F2N4O3/c1-27-19-13(10-26-21(25)16(19)12-7-5-4-6-8-12)11-28(22(27)29)20-17(23)14(30-2)9-15(31-3)18(20)24/h4-10H,11H2,1-3H3,(H2,25,26)
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Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM278500
PNG
(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-met...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(-c4cccnc4)c3N(C)C2=O)c1F
Show InChI InChI=1S/C21H19F2N5O3/c1-27-18-12(9-26-20(24)15(18)11-5-4-6-25-8-11)10-28(21(27)29)19-16(22)13(30-2)7-14(31-3)17(19)23/h4-9H,10H2,1-3H3,(H2,24,26)
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Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM278502
PNG
(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-met...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(\C=C\c4ccccc4)c3N(C)C2=O)c1F
Show InChI InChI=1S/C24H22F2N4O3/c1-29-21-15(12-28-23(27)16(21)10-9-14-7-5-4-6-8-14)13-30(24(29)31)22-19(25)17(32-2)11-18(33-3)20(22)26/h4-12H,13H2,1-3H3,(H2,27,28)/b10-9+
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Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM278505
PNG
(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-8-(3,...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(C4=CCOCC4)c3N(C)C2=O)c1F
Show InChI InChI=1S/C21H22F2N4O4/c1-26-18-12(9-25-20(24)15(18)11-4-6-31-7-5-11)10-27(21(26)28)19-16(22)13(29-2)8-14(30-3)17(19)23/h4,8-9H,5-7,10H2,1-3H3,(H2,24,25)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM278507
PNG
(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-6'-[(2-morph...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(NCCN4CCOCC4)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C24H28F2N4O4/c1-32-17-12-18(33-2)21(26)22(20(17)25)30-14-15-13-28-19(11-16(15)24(3-4-24)23(30)31)27-5-6-29-7-9-34-10-8-29/h11-13H,3-10,14H2,1-2H3,(H,27,28)
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Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM278512
PNG
(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-6'-(pyridin-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(NCc4ccccn4)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C24H22F2N4O3/c1-32-17-10-18(33-2)21(26)22(20(17)25)30-13-14-11-28-19(29-12-15-5-3-4-8-27-15)9-16(14)24(6-7-24)23(30)31/h3-5,8-11H,6-7,12-13H2,1-2H3,(H,28,29)
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Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM278518
PNG
(6'-(cyclopentylamino)-2'-(2,6-difluoro-3,5-dimetho...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(NC4CCCC4)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C23H25F2N3O3/c1-30-16-10-17(31-2)20(25)21(19(16)24)28-12-13-11-26-18(27-14-5-3-4-6-14)9-15(13)23(7-8-23)22(28)29/h9-11,14H,3-8,12H2,1-2H3,(H,26,27)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM278520
PNG
(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-6'-(1-methyl...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4cnn(C)c4)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C22H21F2N5O3/c1-28-11-13(9-26-28)27-17-6-14-12(8-25-17)10-29(21(30)22(14)4-5-22)20-18(23)15(31-2)7-16(32-3)19(20)24/h6-9,11H,4-5,10H2,1-3H3,(H,25,27)
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Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM278520
PNG
(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-6'-(1-methyl...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4cnn(C)c4)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C22H21F2N5O3/c1-28-11-13(9-26-28)27-17-6-14-12(8-25-17)10-29(21(30)22(14)4-5-22)20-18(23)15(31-2)7-16(32-3)19(20)24/h6-9,11H,4-5,10H2,1-3H3,(H,25,27)
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Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM278521
PNG
(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-6'-((1-methy...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(NCc4cnn(C)c4)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C23H23F2N5O3/c1-29-11-13(9-28-29)8-26-18-6-15-14(10-27-18)12-30(22(31)23(15)4-5-23)21-19(24)16(32-2)7-17(33-3)20(21)25/h6-7,9-11H,4-5,8,12H2,1-3H3,(H,26,27)
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Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM278523
PNG
(6'-(cyclohexylamino)-2'-(2,6-difluoro-3,5-dimethox...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(NC4CCCCC4)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C24H27F2N3O3/c1-31-17-11-18(32-2)21(26)22(20(17)25)29-13-14-12-27-19(28-15-6-4-3-5-7-15)10-16(14)24(8-9-24)23(29)30/h10-12,15H,3-9,13H2,1-2H3,(H,27,28)
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Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM278526
PNG
(6'-(cyclobutylamino)-2'-(2,6-difluoro-3,5-dimethox...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(NC4CCC4)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C22H23F2N3O3/c1-29-15-9-16(30-2)19(24)20(18(15)23)27-11-12-10-25-17(26-13-4-3-5-13)8-14(12)22(6-7-22)21(27)28/h8-10,13H,3-7,11H2,1-2H3,(H,25,26)
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Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM278528
PNG
(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-6'-(1-methyl...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(NC4CCN(C)CC4)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C24H28F2N4O3/c1-29-8-4-15(5-9-29)28-19-10-16-14(12-27-19)13-30(23(31)24(16)6-7-24)22-20(25)17(32-2)11-18(33-3)21(22)26/h10-12,15H,4-9,13H2,1-3H3,(H,27,28)
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Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM278530
PNG
(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-8-met...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(C)c3N(c3nnn(C)n3)C2=O)c1F
Show InChI InChI=1S/C18H18F2N8O3/c1-8-14-9(6-22-16(8)21)7-27(18(29)28(14)17-23-25-26(2)24-17)15-12(19)10(30-3)5-11(31-4)13(15)20/h5-6H,7H2,1-4H3,(H2,21,22)
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Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM278530
PNG
(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-8-met...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(C)c3N(c3nnn(C)n3)C2=O)c1F
Show InChI InChI=1S/C18H18F2N8O3/c1-8-14-9(6-22-16(8)21)7-27(18(29)28(14)17-23-25-26(2)24-17)15-12(19)10(30-3)5-11(31-4)13(15)20/h5-6H,7H2,1-4H3,(H2,21,22)
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Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM278534
PNG
(7-amino-1-cyclopentyl-3-(2,6-difluoro-3,5-dimethox...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(C#N)c3N(C3CCCC3)C2=O)c1F
Show InChI InChI=1S/C21H21F2N5O3/c1-30-14-7-15(31-2)17(23)19(16(14)22)27-10-11-9-26-20(25)13(8-24)18(11)28(21(27)29)12-5-3-4-6-12/h7,9,12H,3-6,10H2,1-2H3,(H2,25,26)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM278485
PNG
(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-1,8-d...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(C)c3N(C)C2=O)c1F
Show InChI InChI=1S/C17H18F2N4O3/c1-8-14-9(6-21-16(8)20)7-23(17(24)22(14)2)15-12(18)10(25-3)5-11(26-4)13(15)19/h5-6H,7H2,1-4H3,(H2,20,21)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM278486
PNG
(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-8-eth...)
Show SMILES CCc1c(N)ncc2CN(C(=O)N(C)c12)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C18H20F2N4O3/c1-5-10-15-9(7-22-17(10)21)8-24(18(25)23(15)2)16-13(19)11(26-3)6-12(27-4)14(16)20/h6-7H,5,8H2,1-4H3,(H2,21,22)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM278486
PNG
(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-8-eth...)
Show SMILES CCc1c(N)ncc2CN(C(=O)N(C)c12)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C18H20F2N4O3/c1-5-10-15-9(7-22-17(10)21)8-24(18(25)23(15)2)16-13(19)11(26-3)6-12(27-4)14(16)20/h6-7H,5,8H2,1-4H3,(H2,21,22)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM278488
PNG
(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-8-eth...)
Show SMILES CCOc1c(N)ncc2CN(C(=O)N(C)c12)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C18H20F2N4O4/c1-5-28-16-14-9(7-22-17(16)21)8-24(18(25)23(14)2)15-12(19)10(26-3)6-11(27-4)13(15)20/h6-7H,5,8H2,1-4H3,(H2,21,22)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM278490
PNG
(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-met...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(OCCN4CCN(C)CC4)c3N(C)C2=O)c1F
Show InChI InChI=1S/C23H30F2N6O4/c1-28-5-7-30(8-6-28)9-10-35-21-19-14(12-27-22(21)26)13-31(23(32)29(19)2)20-17(24)15(33-3)11-16(34-4)18(20)25/h11-12H,5-10,13H2,1-4H3,(H2,26,27)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM278490
PNG
(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-met...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(OCCN4CCN(C)CC4)c3N(C)C2=O)c1F
Show InChI InChI=1S/C23H30F2N6O4/c1-28-5-7-30(8-6-28)9-10-35-21-19-14(12-27-22(21)26)13-31(23(32)29(19)2)20-17(24)15(33-3)11-16(34-4)18(20)25/h11-12H,5-10,13H2,1-4H3,(H2,26,27)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM278494
PNG
(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-8-[1-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(-c4cnn(CCO)c4)c3N(C)C2=O)c1F
Show InChI InChI=1S/C21H22F2N6O4/c1-27-18-12(7-25-20(24)15(18)11-8-26-28(9-11)4-5-30)10-29(21(27)31)19-16(22)13(32-2)6-14(33-3)17(19)23/h6-9,30H,4-5,10H2,1-3H3,(H2,24,25)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM278495
PNG
(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-met...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(-c4cnn(c4)C4CCNCC4)c3N(C)C2=O)c1F
Show InChI InChI=1S/C24H27F2N7O3/c1-31-21-14(11-32(24(31)34)22-19(25)16(35-2)8-17(36-3)20(22)26)9-29-23(27)18(21)13-10-30-33(12-13)15-4-6-28-7-5-15/h8-10,12,15,28H,4-7,11H2,1-3H3,(H2,27,29)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM278495
PNG
(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-met...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(-c4cnn(c4)C4CCNCC4)c3N(C)C2=O)c1F
Show InChI InChI=1S/C24H27F2N7O3/c1-31-21-14(11-32(24(31)34)22-19(25)16(35-2)8-17(36-3)20(22)26)9-29-23(27)18(21)13-10-30-33(12-13)15-4-6-28-7-5-15/h8-10,12,15,28H,4-7,11H2,1-3H3,(H2,27,29)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM278501
PNG
(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-met...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(-c4ccncc4)c3N(C)C2=O)c1F
Show InChI InChI=1S/C21H19F2N5O3/c1-27-18-12(9-26-20(24)15(18)11-4-6-25-7-5-11)10-28(21(27)29)19-16(22)13(30-2)8-14(31-3)17(19)23/h4-9H,10H2,1-3H3,(H2,24,26)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM278502
PNG
(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-met...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(\C=C\c4ccccc4)c3N(C)C2=O)c1F
Show InChI InChI=1S/C24H22F2N4O3/c1-29-21-15(12-28-23(27)16(21)10-9-14-7-5-4-6-8-14)13-30(24(29)31)22-19(25)17(32-2)11-18(33-3)20(22)26/h4-12H,13H2,1-3H3,(H2,27,28)/b10-9+
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM278505
PNG
(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-8-(3,...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(C4=CCOCC4)c3N(C)C2=O)c1F
Show InChI InChI=1S/C21H22F2N4O4/c1-26-18-12(9-25-20(24)15(18)11-4-6-31-7-5-11)10-27(21(26)28)19-16(22)13(29-2)8-14(30-3)17(19)23/h4,8-9H,5-7,10H2,1-3H3,(H2,24,25)
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Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM278508
PNG
(6'-amino-2'-(2,6-difluoro-3,5-dimethoxyphenyl)-1'H...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C18H17F2N3O3/c1-25-11-6-12(26-2)15(20)16(14(11)19)23-8-9-7-22-13(21)5-10(9)18(3-4-18)17(23)24/h5-7H,3-4,8H2,1-2H3,(H2,21,22)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM278523
PNG
(6'-(cyclohexylamino)-2'-(2,6-difluoro-3,5-dimethox...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(NC4CCCCC4)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C24H27F2N3O3/c1-31-17-11-18(32-2)21(26)22(20(17)25)29-13-14-12-27-19(28-15-6-4-3-5-7-15)10-16(14)24(8-9-24)23(29)30/h10-12,15H,3-9,13H2,1-2H3,(H,27,28)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM278527
PNG
(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-6'-(3,3-difl...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(NC4CC(F)(F)C4)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C22H21F4N3O3/c1-31-14-6-15(32-2)18(24)19(17(14)23)29-10-11-9-27-16(28-12-7-22(25,26)8-12)5-13(11)21(3-4-21)20(29)30/h5-6,9,12H,3-4,7-8,10H2,1-2H3,(H,27,28)
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Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM278529
PNG
(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-(2-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(C)c3N(C2=O)c2ccccc2F)c1F
Show InChI InChI=1S/C22H19F3N4O3/c1-11-19-12(9-27-21(11)26)10-28(22(30)29(19)14-7-5-4-6-13(14)23)20-17(24)15(31-2)8-16(32-3)18(20)25/h4-9H,10H2,1-3H3,(H2,26,27)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM278531
PNG
(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-8-met...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(C)c3N(Cc3cnn(C)c3)C2=O)c1F
Show InChI InChI=1S/C21H22F2N6O3/c1-11-18-13(7-25-20(11)24)10-29(21(30)28(18)9-12-6-26-27(2)8-12)19-16(22)14(31-3)5-15(32-4)17(19)23/h5-8H,9-10H2,1-4H3,(H2,24,25)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM278533
PNG
(7-amino-1-(cyclopropylmethyl)-3-(2,6-difluoro-3,5-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(C#N)c3N(CC3CC3)C2=O)c1F
Show InChI InChI=1S/C20H19F2N5O3/c1-29-13-5-14(30-2)16(22)18(15(13)21)27-9-11-7-25-19(24)12(6-23)17(11)26(20(27)28)8-10-3-4-10/h5,7,10H,3-4,8-9H2,1-2H3,(H2,24,25)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM278534
PNG
(7-amino-1-cyclopentyl-3-(2,6-difluoro-3,5-dimethox...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(C#N)c3N(C3CCCC3)C2=O)c1F
Show InChI InChI=1S/C21H21F2N5O3/c1-30-14-7-15(31-2)17(23)19(16(14)22)27-10-11-9-26-20(25)13(8-24)18(11)28(21(27)29)12-5-3-4-6-12/h7,9,12H,3-6,10H2,1-2H3,(H2,25,26)
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Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM278535
PNG
(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-[(1...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(C#N)c3N(Cc3cnn(C)c3)C2=O)c1F
Show InChI InChI=1S/C21H19F2N7O3/c1-28-8-11(6-27-28)9-29-18-12(7-26-20(25)13(18)5-24)10-30(21(29)31)19-16(22)14(32-2)4-15(33-3)17(19)23/h4,6-8H,9-10H2,1-3H3,(H2,25,26)
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Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM278535
PNG
(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-[(1...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(C#N)c3N(Cc3cnn(C)c3)C2=O)c1F
Show InChI InChI=1S/C21H19F2N7O3/c1-28-8-11(6-27-28)9-29-18-12(7-26-20(25)13(18)5-24)10-30(21(29)31)19-16(22)14(32-2)4-15(33-3)17(19)23/h4,6-8H,9-10H2,1-3H3,(H2,25,26)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM278536
PNG
(7-amino-1-(3,5-difluorobenzyl)-3-(2,6-difluoro-3,5...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(C#N)c3N(Cc3cc(F)cc(F)c3)C2=O)c1F
Show InChI InChI=1S/C23H17F4N5O3/c1-34-16-6-17(35-2)19(27)21(18(16)26)32-10-12-8-30-22(29)15(7-28)20(12)31(23(32)33)9-11-3-13(24)5-14(25)4-11/h3-6,8H,9-10H2,1-2H3,(H2,29,30)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM278538
PNG
(7-amino-8-chloro-3-(2,6-difluoro-3,5-dimethoxyphen...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(Cl)c3N(C)C2=O)c1F
Show InChI InChI=1S/C16H15ClF2N4O3/c1-22-13-7(5-21-15(20)10(13)17)6-23(16(22)24)14-11(18)8(25-2)4-9(26-3)12(14)19/h4-5H,6H2,1-3H3,(H2,20,21)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM278485
PNG
(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-1,8-d...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(C)c3N(C)C2=O)c1F
Show InChI InChI=1S/C17H18F2N4O3/c1-8-14-9(6-21-16(8)20)7-23(17(24)22(14)2)15-12(18)10(25-3)5-11(26-4)13(15)19/h5-6H,7H2,1-4H3,(H2,20,21)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM278488
PNG
(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-8-eth...)
Show SMILES CCOc1c(N)ncc2CN(C(=O)N(C)c12)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C18H20F2N4O4/c1-5-28-16-14-9(7-22-17(16)21)8-24(18(25)23(14)2)15-12(19)10(26-3)6-11(27-4)13(15)20/h6-7H,5,8H2,1-4H3,(H2,21,22)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM278493
PNG
(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-met...)
Show SMILES CCn1cc(cn1)-c1c(N)ncc2CN(C(=O)N(C)c12)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C21H22F2N6O3/c1-5-28-9-11(8-26-28)15-18-12(7-25-20(15)24)10-29(21(30)27(18)2)19-16(22)13(31-3)6-14(32-4)17(19)23/h6-9H,5,10H2,1-4H3,(H2,24,25)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM278497
PNG
(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-met...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(-c4ccnn4C)c3N(C)C2=O)c1F
Show InChI InChI=1S/C20H20F2N6O3/c1-26-17-10(8-24-19(23)14(17)11-5-6-25-27(11)2)9-28(20(26)29)18-15(21)12(30-3)7-13(31-4)16(18)22/h5-8H,9H2,1-4H3,(H2,23,24)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM278503
PNG
(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-met...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(CCc4ccccc4)c3N(C)C2=O)c1F
Show InChI InChI=1S/C24H24F2N4O3/c1-29-21-15(12-28-23(27)16(21)10-9-14-7-5-4-6-8-14)13-30(24(29)31)22-19(25)17(32-2)11-18(33-3)20(22)26/h4-8,11-12H,9-10,13H2,1-3H3,(H2,27,28)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM278503
PNG
(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-met...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(CCc4ccccc4)c3N(C)C2=O)c1F
Show InChI InChI=1S/C24H24F2N4O3/c1-29-21-15(12-28-23(27)16(21)10-9-14-7-5-4-6-8-14)13-30(24(29)31)22-19(25)17(32-2)11-18(33-3)20(22)26/h4-8,11-12H,9-10,13H2,1-3H3,(H2,27,28)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM278507
PNG
(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-6'-[(2-morph...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(NCCN4CCOCC4)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C24H28F2N4O4/c1-32-17-12-18(33-2)21(26)22(20(17)25)30-14-15-13-28-19(11-16(15)24(3-4-24)23(30)31)27-5-6-29-7-9-34-10-8-29/h11-13H,3-10,14H2,1-2H3,(H,27,28)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM278508
PNG
(6'-amino-2'-(2,6-difluoro-3,5-dimethoxyphenyl)-1'H...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C18H17F2N3O3/c1-25-11-6-12(26-2)15(20)16(14(11)19)23-8-9-7-22-13(21)5-10(9)18(3-4-18)17(23)24/h5-7H,3-4,8H2,1-2H3,(H2,21,22)
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Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM278511
PNG
((S)-2'-(2,6-difluoro-3,5-dimethoxyphenyl)-6'-(2-hy...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(NC[C@H](C)O)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C21H23F2N3O4/c1-11(27)8-24-16-6-13-12(9-25-16)10-26(20(28)21(13)4-5-21)19-17(22)14(29-2)7-15(30-3)18(19)23/h6-7,9,11,27H,4-5,8,10H2,1-3H3,(H,24,25)/t11-/m0/s1
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM278517
PNG
(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-6'-(3-fluoro...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4cccc(F)c4)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C24H20F3N3O3/c1-32-17-10-18(33-2)21(27)22(20(17)26)30-12-13-11-28-19(29-15-5-3-4-14(25)8-15)9-16(13)24(6-7-24)23(30)31/h3-5,8-11H,6-7,12H2,1-2H3,(H,28,29)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM278521
PNG
(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-6'-((1-methy...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(NCc4cnn(C)c4)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C23H23F2N5O3/c1-29-11-13(9-28-29)8-26-18-6-15-14(10-27-18)12-30(22(31)23(15)4-5-23)21-19(24)16(32-2)7-17(33-3)20(21)25/h6-7,9-11H,4-5,8,12H2,1-3H3,(H,26,27)
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Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM278522
PNG
((R)-2'-(2,6-difluoro-3,5-dimethoxyphenyl)-6'-(1-ph...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N[C@H](C)c4ccccc4)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C26H25F2N3O3/c1-15(16-7-5-4-6-8-16)30-21-11-18-17(13-29-21)14-31(25(32)26(18)9-10-26)24-22(27)19(33-2)12-20(34-3)23(24)28/h4-8,11-13,15H,9-10,14H2,1-3H3,(H,29,30)/t15-/m1/s1
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Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM278525
PNG
(6'-(cyclopropylamino)-2'-(2,6-difluoro-3,5-dimetho...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(NC4CC4)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C21H21F2N3O3/c1-28-14-8-15(29-2)18(23)19(17(14)22)26-10-11-9-24-16(25-12-3-4-12)7-13(11)21(5-6-21)20(26)27/h7-9,12H,3-6,10H2,1-2H3,(H,24,25)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM278525
PNG
(6'-(cyclopropylamino)-2'-(2,6-difluoro-3,5-dimetho...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(NC4CC4)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C21H21F2N3O3/c1-28-14-8-15(29-2)18(23)19(17(14)22)26-10-11-9-24-16(25-12-3-4-12)7-13(11)21(5-6-21)20(26)27/h7-9,12H,3-6,10H2,1-2H3,(H,24,25)
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Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM278525
PNG
(6'-(cyclopropylamino)-2'-(2,6-difluoro-3,5-dimetho...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(NC4CC4)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C21H21F2N3O3/c1-28-14-8-15(29-2)18(23)19(17(14)22)26-10-11-9-24-16(25-12-3-4-12)7-13(11)21(5-6-21)20(26)27/h7-9,12H,3-6,10H2,1-2H3,(H,24,25)
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Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM278535
PNG
(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-[(1...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(C#N)c3N(Cc3cnn(C)c3)C2=O)c1F
Show InChI InChI=1S/C21H19F2N7O3/c1-28-8-11(6-27-28)9-29-18-12(7-26-20(25)13(18)5-24)10-30(21(29)31)19-16(22)14(32-2)4-15(33-3)17(19)23/h4,6-8H,9-10H2,1-3H3,(H2,25,26)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM278487
PNG
(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-met...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(C#N)c3N(C)C2=O)c1F
Show InChI InChI=1S/C17H15F2N5O3/c1-23-14-8(6-22-16(21)9(14)5-20)7-24(17(23)25)15-12(18)10(26-2)4-11(27-3)13(15)19/h4,6H,7H2,1-3H3,(H2,21,22)
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Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM278490
PNG
(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-met...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(OCCN4CCN(C)CC4)c3N(C)C2=O)c1F
Show InChI InChI=1S/C23H30F2N6O4/c1-28-5-7-30(8-6-28)9-10-35-21-19-14(12-27-22(21)26)13-31(23(32)29(19)2)20-17(24)15(33-3)11-16(34-4)18(20)25/h11-12H,5-10,13H2,1-4H3,(H2,26,27)
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Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM278492
PNG
(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-met...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(-c4cnn(C)c4)c3N(C)C2=O)c1F
Show InChI InChI=1S/C20H20F2N6O3/c1-26-8-10(7-25-26)14-17-11(6-24-19(14)23)9-28(20(29)27(17)2)18-15(21)12(30-3)5-13(31-4)16(18)22/h5-8H,9H2,1-4H3,(H2,23,24)
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Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM278494
PNG
(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-8-[1-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(-c4cnn(CCO)c4)c3N(C)C2=O)c1F
Show InChI InChI=1S/C21H22F2N6O4/c1-27-18-12(7-25-20(24)15(18)11-8-26-28(9-11)4-5-30)10-29(21(27)31)19-16(22)13(32-2)6-14(33-3)17(19)23/h6-9,30H,4-5,10H2,1-3H3,(H2,24,25)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM278496
PNG
(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-met...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(-c4cn[nH]c4)c3N(C)C2=O)c1F
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM278498
PNG
(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-met...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(-c4ccccc4)c3N(C)C2=O)c1F
Show InChI InChI=1S/C22H20F2N4O3/c1-27-19-13(10-26-21(25)16(19)12-7-5-4-6-8-12)11-28(22(27)29)20-17(23)14(30-2)9-15(31-3)18(20)24/h4-10H,11H2,1-3H3,(H2,25,26)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM278499
PNG
(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-8-(4-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(-c4ccc(F)cc4)c3N(C)C2=O)c1F
Show InChI InChI=1S/C22H19F3N4O3/c1-28-19-12(9-27-21(26)16(19)11-4-6-13(23)7-5-11)10-29(22(28)30)20-17(24)14(31-2)8-15(32-3)18(20)25/h4-9H,10H2,1-3H3,(H2,26,27)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM278499
PNG
(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-8-(4-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(-c4ccc(F)cc4)c3N(C)C2=O)c1F
Show InChI InChI=1S/C22H19F3N4O3/c1-28-19-12(9-27-21(26)16(19)11-4-6-13(23)7-5-11)10-29(22(28)30)20-17(24)14(31-2)8-15(32-3)18(20)25/h4-9H,10H2,1-3H3,(H2,26,27)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM278500
PNG
(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-met...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(-c4cccnc4)c3N(C)C2=O)c1F
Show InChI InChI=1S/C21H19F2N5O3/c1-27-18-12(9-26-20(24)15(18)11-5-4-6-25-8-11)10-28(21(27)29)19-16(22)13(30-2)7-14(31-3)17(19)23/h4-9H,10H2,1-3H3,(H2,24,26)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM278506
PNG
(6-amino-2-(2,6-difluoro-3,5-dimethoxyphenyl)-4,4-d...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)cc3C(C)(C)C2=O)c1F
Show InChI InChI=1S/C18H19F2N3O3/c1-18(2)10-5-13(21)22-7-9(10)8-23(17(18)24)16-14(19)11(25-3)6-12(26-4)15(16)20/h5-7H,8H2,1-4H3,(H2,21,22)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM278506
PNG
(6-amino-2-(2,6-difluoro-3,5-dimethoxyphenyl)-4,4-d...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)cc3C(C)(C)C2=O)c1F
Show InChI InChI=1S/C18H19F2N3O3/c1-18(2)10-5-13(21)22-7-9(10)8-23(17(18)24)16-14(19)11(25-3)6-12(26-4)15(16)20/h5-7H,8H2,1-4H3,(H2,21,22)
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Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM278509
PNG
(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-6'-(methylam...)
Show SMILES CNc1cc2c(CN(C(=O)C22CC2)c2c(F)c(OC)cc(OC)c2F)cn1
Show InChI InChI=1S/C19H19F2N3O3/c1-22-14-6-11-10(8-23-14)9-24(18(25)19(11)4-5-19)17-15(20)12(26-2)7-13(27-3)16(17)21/h6-8H,4-5,9H2,1-3H3,(H,22,23)
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Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM278510
PNG
(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-6'-(tetrahyd...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(NC4CCOCC4)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C23H25F2N3O4/c1-30-16-10-17(31-2)20(25)21(19(16)24)28-12-13-11-26-18(27-14-3-7-32-8-4-14)9-15(13)23(5-6-23)22(28)29/h9-11,14H,3-8,12H2,1-2H3,(H,26,27)
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Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM278511
PNG
((S)-2'-(2,6-difluoro-3,5-dimethoxyphenyl)-6'-(2-hy...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(NC[C@H](C)O)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C21H23F2N3O4/c1-11(27)8-24-16-6-13-12(9-25-16)10-26(20(28)21(13)4-5-21)19-17(22)14(29-2)7-15(30-3)18(19)23/h6-7,9,11,27H,4-5,8,10H2,1-3H3,(H,24,25)/t11-/m0/s1
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Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM278515
PNG
(US10040790, Example 31 | methyl 2'-(2,6-difluoro-3...)
Show SMILES COC(=O)Nc1cc2c(CN(C(=O)C22CC2)c2c(F)c(OC)cc(OC)c2F)cn1
Show InChI InChI=1S/C20H19F2N3O5/c1-28-12-7-13(29-2)16(22)17(15(12)21)25-9-10-8-23-14(24-19(27)30-3)6-11(10)20(4-5-20)18(25)26/h6-8H,4-5,9H2,1-3H3,(H,23,24,27)
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Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM278516
PNG
(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-6'-(pyridin-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4cccnc4)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C23H20F2N4O3/c1-31-16-9-17(32-2)20(25)21(19(16)24)29-12-13-10-27-18(28-14-4-3-7-26-11-14)8-15(13)23(5-6-23)22(29)30/h3-4,7-11H,5-6,12H2,1-2H3,(H,27,28)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM278518
PNG
(6'-(cyclopentylamino)-2'-(2,6-difluoro-3,5-dimetho...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(NC4CCCC4)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C23H25F2N3O3/c1-30-16-10-17(31-2)20(25)21(19(16)24)28-12-13-11-26-18(27-14-5-3-4-6-14)9-15(13)23(7-8-23)22(28)29/h9-11,14H,3-8,12H2,1-2H3,(H,26,27)
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Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM278518
PNG
(6'-(cyclopentylamino)-2'-(2,6-difluoro-3,5-dimetho...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(NC4CCCC4)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C23H25F2N3O3/c1-30-16-10-17(31-2)20(25)21(19(16)24)28-12-13-11-26-18(27-14-5-3-4-6-14)9-15(13)23(7-8-23)22(28)29/h9-11,14H,3-8,12H2,1-2H3,(H,26,27)
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Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM278523
PNG
(6'-(cyclohexylamino)-2'-(2,6-difluoro-3,5-dimethox...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(NC4CCCCC4)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C24H27F2N3O3/c1-31-17-11-18(32-2)21(26)22(20(17)25)29-13-14-12-27-19(28-15-6-4-3-5-7-15)10-16(14)24(8-9-24)23(29)30/h10-12,15H,3-9,13H2,1-2H3,(H,27,28)
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Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM278524
PNG
(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-6'-(trans-4-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N[C@H]4CC[C@H](O)CC4)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C24H27F2N3O4/c1-32-17-10-18(33-2)21(26)22(20(17)25)29-12-13-11-27-19(28-14-3-5-15(30)6-4-14)9-16(13)24(7-8-24)23(29)31/h9-11,14-15,30H,3-8,12H2,1-2H3,(H,27,28)/t14-,15-
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Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM278529
PNG
(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-(2-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(C)c3N(C2=O)c2ccccc2F)c1F
Show InChI InChI=1S/C22H19F3N4O3/c1-11-19-12(9-27-21(11)26)10-28(22(30)29(19)14-7-5-4-6-13(14)23)20-17(24)15(31-2)8-16(32-3)18(20)25/h4-9H,10H2,1-3H3,(H2,26,27)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM278529
PNG
(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-(2-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(C)c3N(C2=O)c2ccccc2F)c1F
Show InChI InChI=1S/C22H19F3N4O3/c1-11-19-12(9-27-21(11)26)10-28(22(30)29(19)14-7-5-4-6-13(14)23)20-17(24)15(31-2)8-16(32-3)18(20)25/h4-9H,10H2,1-3H3,(H2,26,27)
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Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM278532
PNG
(US10040790, Example 48 | methyl [3-(2,6-difluoro-3...)
Show SMILES COC(=O)Nc1ncc2CN(C(=O)N(C)c2c1C)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C19H20F2N4O5/c1-9-15-10(7-22-17(9)23-18(26)30-5)8-25(19(27)24(15)2)16-13(20)11(28-3)6-12(29-4)14(16)21/h6-7H,8H2,1-5H3,(H,22,23,26)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM278537
PNG
(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-(2-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(C#N)c3N(C2=O)c2ccccc2F)c1F
Show InChI InChI=1S/C22H16F3N5O3/c1-32-15-7-16(33-2)18(25)20(17(15)24)29-10-11-9-28-21(27)12(8-26)19(11)30(22(29)31)14-6-4-3-5-13(14)23/h3-7,9H,10H2,1-2H3,(H2,27,28)
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Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM278538
PNG
(7-amino-8-chloro-3-(2,6-difluoro-3,5-dimethoxyphen...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(Cl)c3N(C)C2=O)c1F
Show InChI InChI=1S/C16H15ClF2N4O3/c1-22-13-7(5-21-15(20)10(13)17)6-23(16(22)24)14-11(18)8(25-2)4-9(26-3)12(14)19/h4-5H,6H2,1-3H3,(H2,20,21)
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Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM278485
PNG
(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-1,8-d...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(C)c3N(C)C2=O)c1F
Show InChI InChI=1S/C17H18F2N4O3/c1-8-14-9(6-21-16(8)20)7-23(17(24)22(14)2)15-12(18)10(25-3)5-11(26-4)13(15)19/h5-6H,7H2,1-4H3,(H2,20,21)
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Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM278489
PNG
(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-8-(2-...)
Show SMILES COCCOc1c(N)ncc2CN(C(=O)N(C)c12)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C19H22F2N4O5/c1-24-15-10(8-23-18(22)17(15)30-6-5-27-2)9-25(19(24)26)16-13(20)11(28-3)7-12(29-4)14(16)21/h7-8H,5-6,9H2,1-4H3,(H2,22,23)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM278491
PNG
(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-met...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(Oc4ccccc4)c3N(C)C2=O)c1F
Show InChI InChI=1S/C22H20F2N4O4/c1-27-18-12(10-26-21(25)20(18)32-13-7-5-4-6-8-13)11-28(22(27)29)19-16(23)14(30-2)9-15(31-3)17(19)24/h4-10H,11H2,1-3H3,(H2,25,26)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM278492
PNG
(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-met...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(-c4cnn(C)c4)c3N(C)C2=O)c1F
Show InChI InChI=1S/C20H20F2N6O3/c1-26-8-10(7-25-26)14-17-11(6-24-19(14)23)9-28(20(29)27(17)2)18-15(21)12(30-3)5-13(31-4)16(18)22/h5-8H,9H2,1-4H3,(H2,23,24)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM278495
PNG
(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-met...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(-c4cnn(c4)C4CCNCC4)c3N(C)C2=O)c1F
Show InChI InChI=1S/C24H27F2N7O3/c1-31-21-14(11-32(24(31)34)22-19(25)16(35-2)8-17(36-3)20(22)26)9-29-23(27)18(21)13-10-30-33(12-13)15-4-6-28-7-5-15/h8-10,12,15,28H,4-7,11H2,1-3H3,(H2,27,29)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM278498
PNG
(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-met...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(-c4ccccc4)c3N(C)C2=O)c1F
Show InChI InChI=1S/C22H20F2N4O3/c1-27-19-13(10-26-21(25)16(19)12-7-5-4-6-8-12)11-28(22(27)29)20-17(23)14(30-2)9-15(31-3)18(20)24/h4-10H,11H2,1-3H3,(H2,25,26)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM278504
PNG
(7-amino-8-benzyl-3-(2,6-difluoro-3,5-dimethoxyphen...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(Cc4ccccc4)c3N(C)C2=O)c1F
Show InChI InChI=1S/C23H22F2N4O3/c1-28-20-14(11-27-22(26)15(20)9-13-7-5-4-6-8-13)12-29(23(28)30)21-18(24)16(31-2)10-17(32-3)19(21)25/h4-8,10-11H,9,12H2,1-3H3,(H2,26,27)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM278507
PNG
(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-6'-[(2-morph...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(NCCN4CCOCC4)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C24H28F2N4O4/c1-32-17-12-18(33-2)21(26)22(20(17)25)30-14-15-13-28-19(11-16(15)24(3-4-24)23(30)31)27-5-6-29-7-9-34-10-8-29/h11-13H,3-10,14H2,1-2H3,(H,27,28)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM278508
PNG
(6'-amino-2'-(2,6-difluoro-3,5-dimethoxyphenyl)-1'H...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C18H17F2N3O3/c1-25-11-6-12(26-2)15(20)16(14(11)19)23-8-9-7-22-13(21)5-10(9)18(3-4-18)17(23)24/h5-7H,3-4,8H2,1-2H3,(H2,21,22)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM278512
PNG
(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-6'-(pyridin-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(NCc4ccccn4)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C24H22F2N4O3/c1-32-17-10-18(33-2)21(26)22(20(17)25)30-13-14-11-28-19(29-12-15-5-3-4-8-27-15)9-16(14)24(6-7-24)23(30)31/h3-5,8-11H,6-7,12-13H2,1-2H3,(H,28,29)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM278513
PNG
((S)-2'-(2,6-difluoro-3,5-dimethoxyphenyl)-6'-(tetr...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(NC4CCOC4)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C22H23F2N3O4/c1-29-15-8-16(30-2)19(24)20(18(15)23)27-10-12-9-25-17(26-13-3-6-31-11-13)7-14(12)22(4-5-22)21(27)28/h7-9,13H,3-6,10-11H2,1-2H3,(H,25,26)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM278516
PNG
(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-6'-(pyridin-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4cccnc4)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C23H20F2N4O3/c1-31-16-9-17(32-2)20(25)21(19(16)24)29-12-13-10-27-18(28-14-4-3-7-26-11-14)8-15(13)23(5-6-23)22(29)30/h3-4,7-11H,5-6,12H2,1-2H3,(H,27,28)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM278519
PNG
((S)-2'-(2,6-difluoro-3,5-dimethoxyphenyl)-6'-((tet...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(NC[C@@H]4CCCO4)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C23H25F2N3O4/c1-30-16-9-17(31-2)20(25)21(19(16)24)28-12-13-10-26-18(27-11-14-4-3-7-32-14)8-15(13)23(5-6-23)22(28)29/h8-10,14H,3-7,11-12H2,1-2H3,(H,26,27)/t14-/m0/s1
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM278519
PNG
((S)-2'-(2,6-difluoro-3,5-dimethoxyphenyl)-6'-((tet...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(NC[C@@H]4CCCO4)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C23H25F2N3O4/c1-30-16-9-17(31-2)20(25)21(19(16)24)28-12-13-10-26-18(27-11-14-4-3-7-32-14)8-15(13)23(5-6-23)22(28)29/h8-10,14H,3-7,11-12H2,1-2H3,(H,26,27)/t14-/m0/s1
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM278524
PNG
(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-6'-(trans-4-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N[C@H]4CC[C@H](O)CC4)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C24H27F2N3O4/c1-32-17-10-18(33-2)21(26)22(20(17)25)29-12-13-11-27-19(28-14-3-5-15(30)6-4-14)9-16(13)24(7-8-24)23(29)31/h9-11,14-15,30H,3-8,12H2,1-2H3,(H,27,28)/t14-,15-
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM278532
PNG
(US10040790, Example 48 | methyl [3-(2,6-difluoro-3...)
Show SMILES COC(=O)Nc1ncc2CN(C(=O)N(C)c2c1C)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C19H20F2N4O5/c1-9-15-10(7-22-17(9)23-18(26)30-5)8-25(19(27)24(15)2)16-13(20)11(28-3)6-12(29-4)14(16)21/h6-7H,8H2,1-5H3,(H,22,23,26)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM278532
PNG
(US10040790, Example 48 | methyl [3-(2,6-difluoro-3...)
Show SMILES COC(=O)Nc1ncc2CN(C(=O)N(C)c2c1C)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C19H20F2N4O5/c1-9-15-10(7-22-17(9)23-18(26)30-5)8-25(19(27)24(15)2)16-13(20)11(28-3)6-12(29-4)14(16)21/h6-7H,8H2,1-5H3,(H,22,23,26)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM278537
PNG
(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-(2-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(C#N)c3N(C2=O)c2ccccc2F)c1F
Show InChI InChI=1S/C22H16F3N5O3/c1-32-15-7-16(33-2)18(25)20(17(15)24)29-10-11-9-28-21(27)12(8-26)19(11)30(22(29)31)14-6-4-3-5-13(14)23/h3-7,9H,10H2,1-2H3,(H2,27,28)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM278538
PNG
(7-amino-8-chloro-3-(2,6-difluoro-3,5-dimethoxyphen...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(Cl)c3N(C)C2=O)c1F
Show InChI InChI=1S/C16H15ClF2N4O3/c1-22-13-7(5-21-15(20)10(13)17)6-23(16(22)24)14-11(18)8(25-2)4-9(26-3)12(14)19/h4-5H,6H2,1-3H3,(H2,20,21)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM278493
PNG
(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-met...)
Show SMILES CCn1cc(cn1)-c1c(N)ncc2CN(C(=O)N(C)c12)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C21H22F2N6O3/c1-5-28-9-11(8-26-28)15-18-12(7-25-20(15)24)10-29(21(30)27(18)2)19-16(22)13(31-3)6-14(32-4)17(19)23/h6-9H,5,10H2,1-4H3,(H2,24,25)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM278494
PNG
(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-8-[1-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(-c4cnn(CCO)c4)c3N(C)C2=O)c1F
Show InChI InChI=1S/C21H22F2N6O4/c1-27-18-12(7-25-20(24)15(18)11-8-26-28(9-11)4-5-30)10-29(21(27)31)19-16(22)13(32-2)6-14(33-3)17(19)23/h6-9,30H,4-5,10H2,1-3H3,(H2,24,25)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM278501
PNG
(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-met...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(-c4ccncc4)c3N(C)C2=O)c1F
Show InChI InChI=1S/C21H19F2N5O3/c1-27-18-12(9-26-20(24)15(18)11-4-6-25-7-5-11)10-28(21(27)29)19-16(22)13(30-2)8-14(31-3)17(19)23/h4-9H,10H2,1-3H3,(H2,24,26)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM278501
PNG
(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-met...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(-c4ccncc4)c3N(C)C2=O)c1F
Show InChI InChI=1S/C21H19F2N5O3/c1-27-18-12(9-26-20(24)15(18)11-4-6-25-7-5-11)10-28(21(27)29)19-16(22)13(30-2)8-14(31-3)17(19)23/h4-9H,10H2,1-3H3,(H2,24,26)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM278503
PNG
(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-met...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(CCc4ccccc4)c3N(C)C2=O)c1F
Show InChI InChI=1S/C24H24F2N4O3/c1-29-21-15(12-28-23(27)16(21)10-9-14-7-5-4-6-8-14)13-30(24(29)31)22-19(25)17(32-2)11-18(33-3)20(22)26/h4-8,11-12H,9-10,13H2,1-3H3,(H2,27,28)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM278504
PNG
(7-amino-8-benzyl-3-(2,6-difluoro-3,5-dimethoxyphen...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(Cc4ccccc4)c3N(C)C2=O)c1F
Show InChI InChI=1S/C23H22F2N4O3/c1-28-20-14(11-27-22(26)15(20)9-13-7-5-4-6-8-13)12-29(23(28)30)21-18(24)16(31-2)10-17(32-3)19(21)25/h4-8,10-11H,9,12H2,1-3H3,(H2,26,27)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM278504
PNG
(7-amino-8-benzyl-3-(2,6-difluoro-3,5-dimethoxyphen...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(Cc4ccccc4)c3N(C)C2=O)c1F
Show InChI InChI=1S/C23H22F2N4O3/c1-28-20-14(11-27-22(26)15(20)9-13-7-5-4-6-8-13)12-29(23(28)30)21-18(24)16(31-2)10-17(32-3)19(21)25/h4-8,10-11H,9,12H2,1-3H3,(H2,26,27)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM278506
PNG
(6-amino-2-(2,6-difluoro-3,5-dimethoxyphenyl)-4,4-d...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)cc3C(C)(C)C2=O)c1F
Show InChI InChI=1S/C18H19F2N3O3/c1-18(2)10-5-13(21)22-7-9(10)8-23(17(18)24)16-14(19)11(25-3)6-12(26-4)15(16)20/h5-7H,8H2,1-4H3,(H2,21,22)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM278511
PNG
((S)-2'-(2,6-difluoro-3,5-dimethoxyphenyl)-6'-(2-hy...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(NC[C@H](C)O)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C21H23F2N3O4/c1-11(27)8-24-16-6-13-12(9-25-16)10-26(20(28)21(13)4-5-21)19-17(22)14(29-2)7-15(30-3)18(19)23/h6-7,9,11,27H,4-5,8,10H2,1-3H3,(H,24,25)/t11-/m0/s1
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM278513
PNG
((S)-2'-(2,6-difluoro-3,5-dimethoxyphenyl)-6'-(tetr...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(NC4CCOC4)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C22H23F2N3O4/c1-29-15-8-16(30-2)19(24)20(18(15)23)27-10-12-9-25-17(26-13-3-6-31-11-13)7-14(12)22(4-5-22)21(27)28/h7-9,13H,3-6,10-11H2,1-2H3,(H,25,26)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM278514
PNG
(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-6'-(2-(4-met...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(NCCN4CCN(C)CC4)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C25H31F2N5O3/c1-30-8-10-31(11-9-30)7-6-28-20-12-17-16(14-29-20)15-32(24(33)25(17)4-5-25)23-21(26)18(34-2)13-19(35-3)22(23)27/h12-14H,4-11,15H2,1-3H3,(H,28,29)
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Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM278515
PNG
(US10040790, Example 31 | methyl 2'-(2,6-difluoro-3...)
Show SMILES COC(=O)Nc1cc2c(CN(C(=O)C22CC2)c2c(F)c(OC)cc(OC)c2F)cn1
Show InChI InChI=1S/C20H19F2N3O5/c1-28-12-7-13(29-2)16(22)17(15(12)21)25-9-10-8-23-14(24-19(27)30-3)6-11(10)20(4-5-20)18(25)26/h6-8H,4-5,9H2,1-3H3,(H,23,24,27)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM278519
PNG
((S)-2'-(2,6-difluoro-3,5-dimethoxyphenyl)-6'-((tet...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(NC[C@@H]4CCCO4)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C23H25F2N3O4/c1-30-16-9-17(31-2)20(25)21(19(16)24)28-12-13-10-26-18(27-11-14-4-3-7-32-14)8-15(13)23(5-6-23)22(28)29/h8-10,14H,3-7,11-12H2,1-2H3,(H,26,27)/t14-/m0/s1
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM278520
PNG
(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-6'-(1-methyl...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4cnn(C)c4)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C22H21F2N5O3/c1-28-11-13(9-26-28)27-17-6-14-12(8-25-17)10-29(21(30)22(14)4-5-22)20-18(23)15(31-2)7-16(32-3)19(20)24/h6-9,11H,4-5,10H2,1-3H3,(H,25,27)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM278522
PNG
((R)-2'-(2,6-difluoro-3,5-dimethoxyphenyl)-6'-(1-ph...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N[C@H](C)c4ccccc4)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C26H25F2N3O3/c1-15(16-7-5-4-6-8-16)30-21-11-18-17(13-29-21)14-31(25(32)26(18)9-10-26)24-22(27)19(33-2)12-20(34-3)23(24)28/h4-8,11-13,15H,9-10,14H2,1-3H3,(H,29,30)/t15-/m1/s1
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM278522
PNG
((R)-2'-(2,6-difluoro-3,5-dimethoxyphenyl)-6'-(1-ph...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N[C@H](C)c4ccccc4)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C26H25F2N3O3/c1-15(16-7-5-4-6-8-16)30-21-11-18-17(13-29-21)14-31(25(32)26(18)9-10-26)24-22(27)19(33-2)12-20(34-3)23(24)28/h4-8,11-13,15H,9-10,14H2,1-3H3,(H,29,30)/t15-/m1/s1
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM278524
PNG
(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-6'-(trans-4-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N[C@H]4CC[C@H](O)CC4)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C24H27F2N3O4/c1-32-17-10-18(33-2)21(26)22(20(17)25)29-12-13-11-27-19(28-14-3-5-15(30)6-4-14)9-16(13)24(7-8-24)23(29)31/h9-11,14-15,30H,3-8,12H2,1-2H3,(H,27,28)/t14-,15-
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM278528
PNG
(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-6'-(1-methyl...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(NC4CCN(C)CC4)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C24H28F2N4O3/c1-29-8-4-15(5-9-29)28-19-10-16-14(12-27-19)13-30(23(31)24(16)6-7-24)22-20(25)17(32-2)11-18(33-3)21(22)26/h10-12,15H,4-9,13H2,1-3H3,(H,27,28)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM278528
PNG
(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-6'-(1-methyl...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(NC4CCN(C)CC4)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C24H28F2N4O3/c1-29-8-4-15(5-9-29)28-19-10-16-14(12-27-19)13-30(23(31)24(16)6-7-24)22-20(25)17(32-2)11-18(33-3)21(22)26/h10-12,15H,4-9,13H2,1-3H3,(H,27,28)
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Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM278530
PNG
(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-8-met...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(C)c3N(c3nnn(C)n3)C2=O)c1F
Show InChI InChI=1S/C18H18F2N8O3/c1-8-14-9(6-22-16(8)21)7-27(18(29)28(14)17-23-25-26(2)24-17)15-12(19)10(30-3)5-11(31-4)13(15)20/h5-6H,7H2,1-4H3,(H2,21,22)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM278531
PNG
(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-8-met...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(C)c3N(Cc3cnn(C)c3)C2=O)c1F
Show InChI InChI=1S/C21H22F2N6O3/c1-11-18-13(7-25-20(11)24)10-29(21(30)28(18)9-12-6-26-27(2)8-12)19-16(22)14(31-3)5-15(32-4)17(19)23/h5-8H,9-10H2,1-4H3,(H2,24,25)
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Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM278533
PNG
(7-amino-1-(cyclopropylmethyl)-3-(2,6-difluoro-3,5-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(C#N)c3N(CC3CC3)C2=O)c1F
Show InChI InChI=1S/C20H19F2N5O3/c1-29-13-5-14(30-2)16(22)18(15(13)21)27-9-11-7-25-19(24)12(6-23)17(11)26(20(27)28)8-10-3-4-10/h5,7,10H,3-4,8-9H2,1-2H3,(H2,24,25)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM278534
PNG
(7-amino-1-cyclopentyl-3-(2,6-difluoro-3,5-dimethox...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(C#N)c3N(C3CCCC3)C2=O)c1F
Show InChI InChI=1S/C21H21F2N5O3/c1-30-14-7-15(31-2)17(23)19(16(14)22)27-10-11-9-26-20(25)13(8-24)18(11)28(21(27)29)12-5-3-4-6-12/h7,9,12H,3-6,10H2,1-2H3,(H2,25,26)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM278489
PNG
(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-8-(2-...)
Show SMILES COCCOc1c(N)ncc2CN(C(=O)N(C)c12)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C19H22F2N4O5/c1-24-15-10(8-23-18(22)17(15)30-6-5-27-2)9-25(19(24)26)16-13(20)11(28-3)7-12(29-4)14(16)21/h7-8H,5-6,9H2,1-4H3,(H2,22,23)
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Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM278496
PNG
(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-met...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(-c4cn[nH]c4)c3N(C)C2=O)c1F
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM278509
PNG
(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-6'-(methylam...)
Show SMILES CNc1cc2c(CN(C(=O)C22CC2)c2c(F)c(OC)cc(OC)c2F)cn1
Show InChI InChI=1S/C19H19F2N3O3/c1-22-14-6-11-10(8-23-14)9-24(18(25)19(11)4-5-19)17-15(20)12(26-2)7-13(27-3)16(17)21/h6-8H,4-5,9H2,1-3H3,(H,22,23)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM278510
PNG
(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-6'-(tetrahyd...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(NC4CCOCC4)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C23H25F2N3O4/c1-30-16-10-17(31-2)20(25)21(19(16)24)28-12-13-11-26-18(27-14-3-7-32-8-4-14)9-15(13)23(5-6-23)22(28)29/h9-11,14H,3-8,12H2,1-2H3,(H,26,27)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM278514
PNG
(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-6'-(2-(4-met...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(NCCN4CCN(C)CC4)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C25H31F2N5O3/c1-30-8-10-31(11-9-30)7-6-28-20-12-17-16(14-29-20)15-32(24(33)25(17)4-5-25)23-21(26)18(34-2)13-19(35-3)22(23)27/h12-14H,4-11,15H2,1-3H3,(H,28,29)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM278516
PNG
(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-6'-(pyridin-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4cccnc4)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C23H20F2N4O3/c1-31-16-9-17(32-2)20(25)21(19(16)24)29-12-13-10-27-18(28-14-4-3-7-26-11-14)8-15(13)23(5-6-23)22(29)30/h3-4,7-11H,5-6,12H2,1-2H3,(H,27,28)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM278517
PNG
(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-6'-(3-fluoro...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4cccc(F)c4)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C24H20F3N3O3/c1-32-17-10-18(33-2)21(27)22(20(17)26)30-12-13-11-28-19(29-15-5-3-4-14(25)8-15)9-16(13)24(6-7-24)23(30)31/h3-5,8-11H,6-7,12H2,1-2H3,(H,28,29)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM278521
PNG
(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-6'-((1-methy...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(NCc4cnn(C)c4)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C23H23F2N5O3/c1-29-11-13(9-28-29)8-26-18-6-15-14(10-27-18)12-30(22(31)23(15)4-5-23)21-19(24)16(32-2)7-17(33-3)20(21)25/h6-7,9-11H,4-5,8,12H2,1-3H3,(H,26,27)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM278526
PNG
(6'-(cyclobutylamino)-2'-(2,6-difluoro-3,5-dimethox...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(NC4CCC4)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C22H23F2N3O3/c1-29-15-9-16(30-2)19(24)20(18(15)23)27-11-12-10-25-17(26-13-4-3-5-13)8-14(12)22(6-7-22)21(27)28/h8-10,13H,3-7,11H2,1-2H3,(H,25,26)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM278527
PNG
(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-6'-(3,3-difl...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(NC4CC(F)(F)C4)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C22H21F4N3O3/c1-31-14-6-15(32-2)18(24)19(17(14)23)29-10-11-9-27-16(28-12-7-22(25,26)8-12)5-13(11)21(3-4-21)20(29)30/h5-6,9,12H,3-4,7-8,10H2,1-2H3,(H,27,28)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM278537
PNG
(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-(2-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(C#N)c3N(C2=O)c2ccccc2F)c1F
Show InChI InChI=1S/C22H16F3N5O3/c1-32-15-7-16(33-2)18(25)20(17(15)24)29-10-11-9-28-21(27)12(8-26)19(11)30(22(29)31)14-6-4-3-5-13(14)23/h3-7,9H,10H2,1-2H3,(H2,27,28)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent




US Patent US10040790 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%