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Patent code US10040798

Compile Data Set for Download or QSAR
Found 117 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278744
PNG
(2-[(3R)- or (3S)-azepan- 3-ylamino]-N-[3- (difluor...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2ccc3ccc(N[C@@H]4CCCCNC4)nn23)c(n1)C(F)F
Show InChI InChI=1S/C19H23F2N7O.C2HF3O2/c1-27-11-14(17(26-27)18(20)21)24-19(29)15-7-5-13-6-8-16(25-28(13)15)23-12-4-2-3-9-22-10-12;3-2(4,5)1(6)7/h5-8,11-12,18,22H,2-4,9-10H2,1H3,(H,23,25)(H,24,29);(H,6,7)/t12-;/m1./s1
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n/an/a 0.200n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278745
PNG
(2-[(3R)- or (3S)-azepan- 3-ylamino]-N-[3- (difluor...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2ccc3ccc(N[C@H]4CCCCNC4)nn23)c(n1)C(F)F
Show InChI InChI=1S/C19H23F2N7O.C2HF3O2/c1-27-11-14(17(26-27)18(20)21)24-19(29)15-7-5-13-6-8-16(25-28(13)15)23-12-4-2-3-9-22-10-12;3-2(4,5)1(6)7/h5-8,11-12,18,22H,2-4,9-10H2,1H3,(H,23,25)(H,24,29);(H,6,7)/t12-;/m0./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278715
PNG
(2-[(3R)-3- aminopiperidin-1-yl]-N- [1-methyl-3- (t...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2ccc3ccc(nn23)N2CCC[C@@H](N)C2)c(n1)C(F)(F)F
Show InChI InChI=1S/C18H20F3N7O.C2HF3O2/c1-26-10-13(16(25-26)18(19,20)21)23-17(29)14-6-4-12-5-7-15(24-28(12)14)27-8-2-3-11(22)9-27;3-2(4,5)1(6)7/h4-7,10-11H,2-3,8-9,22H2,1H3,(H,23,29);(H,6,7)/t11-;/m1./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278716
PNG
(2-[(3R)-3- aminopiperidin-1-yl]-N- [3-(difluoromet...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2ccc3ccc(nn23)N2CCC[C@@H](N)C2)c(n1)C(F)F
Show InChI InChI=1S/C18H21F2N7O.C2HF3O2/c1-25-10-13(16(24-25)17(19)20)22-18(28)14-6-4-12-5-7-15(23-27(12)14)26-8-2-3-11(21)9-26;3-2(4,5)1(6)7/h4-7,10-11,17H,2-3,8-9,21H2,1H3,(H,22,28);(H,6,7)/t11-;/m1./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278732
PNG
(2-{[(1R,2S)-2- aminocyclohexyl]amino}- N-(3-cyano-...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2ccc3ccc(N[C@@H]4CCCC[C@@H]4N)nn23)c(n1)C#N
Show InChI InChI=1S/C19H22N8O.C2HF3O2/c1-26-11-16(15(10-20)24-26)23-19(28)17-8-6-12-7-9-18(25-27(12)17)22-14-5-3-2-4-13(14)21;3-2(4,5)1(6)7/h6-9,11,13-14H,2-5,21H2,1H3,(H,22,25)(H,23,28);(H,6,7)/t13-,14+;/m0./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278719
PNG
(N-[3-(difluoromethyl)- 1-methyl-1H-pyrazol-4- yl]-...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2ccc3ccc(N[C@@H]4CCCNC4)nn23)c(n1)C(F)F
Show InChI InChI=1S/C18H21F2N7O.C2HF3O2/c1-26-10-13(16(25-26)17(19)20)23-18(28)14-6-4-12-5-7-15(24-27(12)14)22-11-3-2-8-21-9-11;3-2(4,5)1(6)7/h4-7,10-11,17,21H,2-3,8-9H2,1H3,(H,22,24)(H,23,28);(H,6,7)/t11-;/m1./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278722
PNG
(2-{[(1R,2S)-2- aminocyclo- hexyl]amino}-N-[3- (dif...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2ccc3ccc(N[C@@H]4CCCC[C@@H]4N)nn23)c(n1)C(F)F
Show InChI InChI=1S/C19H23F2N7O.C2HF3O2/c1-27-10-14(17(26-27)18(20)21)24-19(29)15-8-6-11-7-9-16(25-28(11)15)23-13-5-3-2-4-12(13)22;3-2(4,5)1(6)7/h6-10,12-13,18H,2-5,22H2,1H3,(H,23,25)(H,24,29);(H,6,7)/t12-,13+;/m0./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278728
PNG
(2-{[(1R,2S)-2- aminocyclohexyl]amino}- N-(3-chloro...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2ccc3ccc(N[C@@H]4CCCC[C@@H]4N)nn23)c(Cl)n1
Show InChI InChI=1S/C18H22ClN7O.C2HF3O2/c1-25-10-14(17(19)24-25)22-18(27)15-8-6-11-7-9-16(23-26(11)15)21-13-5-3-2-4-12(13)20;3-2(4,5)1(6)7/h6-10,12-13H,2-5,20H2,1H3,(H,21,23)(H,22,27);(H,6,7)/t12-,13+;/m0./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278709
PNG
(N-[1-methyl-3- (trifluoromethyl)-1H- pyrazol-4-yl]...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2ccc3ccc(N[C@@H]4CCCNC4)nn23)c(n1)C(F)(F)F
Show InChI InChI=1S/C18H20F3N7O.C2HF3O2/c1-27-10-13(16(26-27)18(19,20)21)24-17(29)14-6-4-12-5-7-15(25-28(12)14)23-11-3-2-8-22-9-11;3-2(4,5)1(6)7/h4-7,10-11,22H,2-3,8-9H2,1H3,(H,23,25)(H,24,29);(H,6,7)/t11-;/m1./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278749
PNG
(2-(3,8- diazabicyclo[3.2.1]oct- 3-yl)-N-[3- (diflu...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2ccc3ccc(nn23)N2CC3CCC(C2)N3)c(n1)C(F)F
Show InChI InChI=1S/C19H21F2N7O.C2HF3O2/c1-26-10-14(17(25-26)18(20)21)23-19(29)15-6-4-13-5-7-16(24-28(13)15)27-8-11-2-3-12(9-27)22-11;3-2(4,5)1(6)7/h4-7,10-12,18,22H,2-3,8-9H2,1H3,(H,23,29);(H,6,7)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278743
PNG
(2-[(3R)- or (3S)-azepan- 3-ylamino]-N-[1- methyl-3...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2ccc3ccc(N[C@H]4CCCCNC4)nn23)c(n1)C(F)(F)F
Show InChI InChI=1S/C19H22F3N7O.C2HF3O2/c1-28-11-14(17(27-28)19(20,21)22)25-18(30)15-7-5-13-6-8-16(26-29(13)15)24-12-4-2-3-9-23-10-12;3-2(4,5)1(6)7/h5-8,11-12,23H,2-4,9-10H2,1H3,(H,24,26)(H,25,30);(H,6,7)/t12-;/m0./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278742
PNG
(2-[(3R)- or (3S)-azepan- 3-ylamino]-N-[1- methyl-3...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2ccc3ccc(N[C@@H]4CCCCNC4)nn23)c(n1)C(F)(F)F
Show InChI InChI=1S/C19H22F3N7O.C2HF3O2/c1-28-11-14(17(27-28)19(20,21)22)25-18(30)15-7-5-13-6-8-16(26-29(13)15)24-12-4-2-3-9-23-10-12;3-2(4,5)1(6)7/h5-8,11-12,23H,2-4,9-10H2,1H3,(H,24,26)(H,25,30);(H,6,7)/t12-;/m1./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278777
PNG
(2-{[(1R,2S)-2- aminocyclohexyl]amino}- N-(2-cyanot...)
Show SMILES OC(=O)C(F)(F)F.N[C@H]1CCCC[C@H]1Nc1ccc2ccc(C(=O)Nc3ccsc3C#N)n2n1
Show InChI InChI=1S/C19H20N6OS.C2HF3O2/c20-11-17-15(9-10-27-17)23-19(26)16-7-5-12-6-8-18(24-25(12)16)22-14-4-2-1-3-13(14)21;3-2(4,5)1(6)7/h5-10,13-14H,1-4,21H2,(H,22,24)(H,23,26);(H,6,7)/t13-,14+;/m0./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278717
PNG
(N-[3-(difluoromethyl)- 1-methyl-1H-pyrazol-4- yl]-...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2ccc3ccc(nn23)N2CCNCC2)c(n1)C(F)F
Show InChI InChI=1S/C17H19F2N7O.C2HF3O2/c1-24-10-12(15(23-24)16(18)19)21-17(27)13-4-2-11-3-5-14(22-26(11)13)25-8-6-20-7-9-25;3-2(4,5)1(6)7/h2-5,10,16,20H,6-9H2,1H3,(H,21,27);(H,6,7)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278725
PNG
(2-{[(1R,2S)-2-amino- cyclohexyl]amino}- N-(3-bromo...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2ccc3ccc(N[C@@H]4CCCC[C@@H]4N)nn23)c(Br)n1
Show InChI InChI=1S/C18H22BrN7O.C2HF3O2/c1-25-10-14(17(19)24-25)22-18(27)15-8-6-11-7-9-16(23-26(11)15)21-13-5-3-2-4-12(13)20;3-2(4,5)1(6)7/h6-10,12-13H,2-5,20H2,1H3,(H,21,23)(H,22,27);(H,6,7)/t12-,13+;/m0./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278721
PNG
(2-(5,8- diazaspiro[2.6]non-5- yl)-N-[3- (difluorom...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2ccc3ccc(nn23)N2CCNCC3(CC3)C2)c(n1)C(F)F
Show InChI InChI=1S/C20H23F2N7O.C2HF3O2/c1-27-10-14(17(26-27)18(21)22)24-19(30)15-4-2-13-3-5-16(25-29(13)15)28-9-8-23-11-20(12-28)6-7-20;3-2(4,5)1(6)7/h2-5,10,18,23H,6-9,11-12H2,1H3,(H,24,30);(H,6,7)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278718
PNG
(2-(1,4-diazepan-1-yl)- N-[3-(difluoromethyl)- 1-me...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2ccc3ccc(nn23)N2CCCNCC2)c(n1)C(F)F
Show InChI InChI=1S/C18H21F2N7O.C2HF3O2/c1-25-11-13(16(24-25)17(19)20)22-18(28)14-5-3-12-4-6-15(23-27(12)14)26-9-2-7-21-8-10-26;3-2(4,5)1(6)7/h3-6,11,17,21H,2,7-10H2,1H3,(H,22,28);(H,6,7)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278741
PNG
(2-[(1S,4S)- or (1R,4R)- 2,5- diazabicyclo[2.2.2]oc...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2ccc3ccc(nn23)N2C[C@H]3CC[C@@H]2CN3)c(n1)C(F)F
Show InChI InChI=1S/C19H21F2N7O.C2HF3O2/c1-26-10-14(17(25-26)18(20)21)23-19(29)15-6-4-12-5-7-16(24-28(12)15)27-9-11-2-3-13(27)8-22-11;3-2(4,5)1(6)7/h4-7,10-11,13,18,22H,2-3,8-9H2,1H3,(H,23,29);(H,6,7)/t11-,13-;/m1./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278727
PNG
(2-(azepan-3-ylamino)- N-[3-(difluoromethyl)- 1-met...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2ccc3ccc(NC4CCCCNC4)nn23)c(n1)C(F)F
Show InChI InChI=1S/C19H23F2N7O.C2HF3O2/c1-27-11-14(17(26-27)18(20)21)24-19(29)15-7-5-13-6-8-16(25-28(13)15)23-12-4-2-3-9-22-10-12;3-2(4,5)1(6)7/h5-8,11-12,18,22H,2-4,9-10H2,1H3,(H,23,25)(H,24,29);(H,6,7)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278787
PNG
(2-{[(1R,2S)-2- aminocyclohexyl]amino}- N-(4-chloro...)
Show SMILES OC(=O)C(F)(F)F.N[C@H]1CCCC[C@H]1Nc1ccc2ccc(C(=O)Nc3cscc3Cl)n2n1
Show InChI InChI=1S/C18H20ClN5OS.C2HF3O2/c19-12-9-26-10-15(12)22-18(25)16-7-5-11-6-8-17(23-24(11)16)21-14-4-2-1-3-13(14)20;3-2(4,5)1(6)7/h5-10,13-14H,1-4,20H2,(H,21,23)(H,22,25);(H,6,7)/t13-,14+;/m0./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278818
PNG
(2-(3,8- diazabicyclo[3.2.1]oct- 8-yl)-N-[1-methyl-...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2ccc3ccc(nn23)N2C3CCC2CNC3)c(n1)C(F)(F)F
Show InChI InChI=1S/C19H20F3N7O.C2HF3O2/c1-27-10-14(17(26-27)19(20,21)22)24-18(30)15-6-4-11-5-7-16(25-29(11)15)28-12-2-3-13(28)9-23-8-12;3-2(4,5)1(6)7/h4-7,10,12-13,23H,2-3,8-9H2,1H3,(H,24,30);(H,6,7)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278775
PNG
(2-{[(1R,2S)-2- aminocyclohexyl]amino}- N-(4-cyanot...)
Show SMILES OC(=O)C(F)(F)F.N[C@H]1CCCC[C@H]1Nc1ccc2ccc(C(=O)Nc3cscc3C#N)n2n1
Show InChI InChI=1S/C19H20N6OS.C2HF3O2/c20-9-12-10-27-11-16(12)23-19(26)17-7-5-13-6-8-18(24-25(13)17)22-15-4-2-1-3-14(15)21;3-2(4,5)1(6)7/h5-8,10-11,14-15H,1-4,21H2,(H,22,24)(H,23,26);(H,6,7)/t14-,15+;/m0./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278740
PNG
(2-[(1S,4S)- or (1R,4R)- 2,5- diazabicyclo[2.2.2]oc...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2ccc3ccc(nn23)N2C[C@@H]3CC[C@H]2CN3)c(n1)C(F)F
Show InChI InChI=1S/C19H21F2N7O.C2HF3O2/c1-26-10-14(17(25-26)18(20)21)23-19(29)15-6-4-12-5-7-16(24-28(12)15)27-9-11-2-3-13(27)8-22-11;3-2(4,5)1(6)7/h4-7,10-11,13,18,22H,2-3,8-9H2,1H3,(H,23,29);(H,6,7)/t11-,13-;/m0./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278752
PNG
(2-[(1S,5S)- or (1R,5R)- 3,6- diazabicyclo[3.2.1]oc...)
Show SMILES Cn1cc(NC(=O)c2ccc3ccc(nn23)N2C[C@@H]3C[C@H](C2)N3)c(n1)C(F)F
Show InChI InChI=1S/C18H19F2N7O/c1-25-9-13(16(24-25)17(19)20)22-18(28)14-4-2-12-3-5-15(23-27(12)14)26-7-10-6-11(8-26)21-10/h2-5,9-11,17,21H,6-8H2,1H3,(H,22,28)/t10-,11+
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278773
PNG
(2-{[(1R,2S)-2- aminocyclohexyl]amino}- N-(2-chloro...)
Show SMILES OC(=O)C(F)(F)F.N[C@H]1CCCC[C@H]1Nc1ccc2ccc(C(=O)Nc3ccsc3Cl)n2n1
Show InChI InChI=1S/C18H20ClN5OS.C2HF3O2/c19-17-14(9-10-26-17)22-18(25)15-7-5-11-6-8-16(23-24(11)15)21-13-4-2-1-3-12(13)20;3-2(4,5)1(6)7/h5-10,12-13H,1-4,20H2,(H,21,23)(H,22,25);(H,6,7)/t12-,13+;/m0./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278720
PNG
(2-(2,5- diazabicyclo[2.2.2]oct- 2-yl)-N-[3- (diflu...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2ccc3ccc(nn23)N2CC3CCC2CN3)c(n1)C(F)F
Show InChI InChI=1S/C19H21F2N7O.C2HF3O2/c1-26-10-14(17(25-26)18(20)21)23-19(29)15-6-4-12-5-7-16(24-28(12)15)27-9-11-2-3-13(27)8-22-11;3-2(4,5)1(6)7/h4-7,10-11,13,18,22H,2-3,8-9H2,1H3,(H,23,29);(H,6,7)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278821
PNG
(2-[(1S,5R)- or (1R,5S)- 3,6- diazabicyclo[3.2.1]oc...)
Show SMILES Cn1cc(NC(=O)c2ccc3ccc(nn23)N2C[C@H]3C[C@@H]2CNC3)c(n1)C(F)F
Show InChI InChI=1S/C19H21F2N7O/c1-26-10-14(17(25-26)18(20)21)23-19(29)15-4-2-12-3-5-16(24-28(12)15)27-9-11-6-13(27)8-22-7-11/h2-5,10-11,13,18,22H,6-9H2,1H3,(H,23,29)/t11-,13+/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278805
PNG
(N-(2- cyanophenyl)-2- [(3R)-piperidin-3- ylamino]p...)
Show SMILES OC(=O)C(F)(F)F.O=C(Nc1ccccc1C#N)c1ccc2ccc(N[C@@H]3CCCNC3)nn12
Show InChI InChI=1S/C20H20N6O.C2HF3O2/c21-12-14-4-1-2-6-17(14)24-20(27)18-9-7-16-8-10-19(25-26(16)18)23-15-5-3-11-22-13-15;3-2(4,5)1(6)7/h1-2,4,6-10,15,22H,3,5,11,13H2,(H,23,25)(H,24,27);(H,6,7)/t15-;/m1./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278767
PNG
(2-{[(1R,2S)-2- aminocyclohexyl]amino}- N-(2- chlor...)
Show SMILES OC(=O)C(F)(F)F.N[C@H]1CCCC[C@H]1Nc1ccc2ccc(C(=O)Nc3ccccc3Cl)n2n1
Show InChI InChI=1S/C20H22ClN5O.C2HF3O2/c21-14-5-1-3-7-16(14)24-20(27)18-11-9-13-10-12-19(25-26(13)18)23-17-8-4-2-6-15(17)22;3-2(4,5)1(6)7/h1,3,5,7,9-12,15,17H,2,4,6,8,22H2,(H,23,25)(H,24,27);(H,6,7)/t15-,17+;/m0./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278806
PNG
(2-{[(1R,2S)-2- aminocyclohexyl] amino}-N-(2- cyano...)
Show SMILES OC(=O)C(F)(F)F.N[C@H]1CCCC[C@H]1Nc1ccc2ccc(C(=O)Nc3ccccc3C#N)n2n1
Show InChI InChI=1S/C21H22N6O.C2HF3O2/c22-13-14-5-1-3-7-17(14)25-21(28)19-11-9-15-10-12-20(26-27(15)19)24-18-8-4-2-6-16(18)23;3-2(4,5)1(6)7/h1,3,5,7,9-12,16,18H,2,4,6,8,23H2,(H,24,26)(H,25,28);(H,6,7)/t16-,18+;/m0./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278765
PNG
(2-{[(1R,2S)-2- aminocyclohexyl]amino}- N-(4-bromot...)
Show SMILES OC(=O)C(F)(F)F.N[C@H]1CCCC[C@H]1Nc1ccc2ccc(C(=O)Nc3cscc3Br)n2n1
Show InChI InChI=1S/C18H20BrN5OS.C2HF3O2/c19-12-9-26-10-15(12)22-18(25)16-7-5-11-6-8-17(23-24(11)16)21-14-4-2-1-3-13(14)20;3-2(4,5)1(6)7/h5-10,13-14H,1-4,20H2,(H,21,23)(H,22,25);(H,6,7)/t13-,14+;/m0./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278809
PNG
(2-[(3R)- or (3S)- azepan-3- ylamino]-N-(2- cyanoph...)
Show SMILES OC(=O)C(F)(F)F.O=C(Nc1ccccc1C#N)c1ccc2ccc(N[C@H]3CCCCNC3)nn12
Show InChI InChI=1S/C21H22N6O.C2HF3O2/c22-13-15-5-1-2-7-18(15)25-21(28)19-10-8-17-9-11-20(26-27(17)19)24-16-6-3-4-12-23-14-16;3-2(4,5)1(6)7/h1-2,5,7-11,16,23H,3-4,6,12,14H2,(H,24,26)(H,25,28);(H,6,7)/t16-;/m0./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278750
PNG
(2-(3,8- diazabicyclo[3.2.1]oct- 3-yl)-N-[1-methyl-...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2ccc3ccc(nn23)N2CC3CCC(C2)N3)c(n1)C(F)(F)F
Show InChI InChI=1S/C19H20F3N7O.C2HF3O2/c1-27-10-14(17(26-27)19(20,21)22)24-18(30)15-6-4-13-5-7-16(25-29(13)15)28-8-11-2-3-12(9-28)23-11;3-2(4,5)1(6)7/h4-7,10-12,23H,2-3,8-9H2,1H3,(H,24,30);(H,6,7)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278779
PNG
(2-{[(1R,2S)-2- aminocyclohexyl]amino}- N-(2-bromot...)
Show SMILES OC(=O)C(F)(F)F.N[C@H]1CCCC[C@H]1Nc1ccc2ccc(C(=O)Nc3ccsc3Br)n2n1
Show InChI InChI=1S/C18H20BrN5OS.C2HF3O2/c19-17-14(9-10-26-17)22-18(25)15-7-5-11-6-8-16(23-24(11)15)21-13-4-2-1-3-12(13)20;3-2(4,5)1(6)7/h5-10,12-13H,1-4,20H2,(H,21,23)(H,22,25);(H,6,7)/t12-,13+;/m0./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278760
PNG
(2-{[(1R,2S)-2- aminocyclohexyl]amino}- N-(2-bromo-...)
Show SMILES OC(=O)C(F)(F)F.N[C@H]1CCCC[C@H]1Nc1ccc2ccc(C(=O)Nc3ccccc3Br)n2n1
Show InChI InChI=1S/C20H22BrN5O.C2HF3O2/c21-14-5-1-3-7-16(14)24-20(27)18-11-9-13-10-12-19(25-26(13)18)23-17-8-4-2-6-15(17)22;3-2(4,5)1(6)7/h1,3,5,7,9-12,15,17H,2,4,6,8,22H2,(H,23,25)(H,24,27);(H,6,7)/t15-,17+;/m0./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278723
PNG
(N-[3-(difluoromethyl)- 1-methyl-1H-pyrazol-4- yl]-...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2ccc3ccc(N[C@@H]4CCCC[C@@H]4O)nn23)c(n1)C(F)F
Show InChI InChI=1S/C19H22F2N6O2.C2HF3O2/c1-26-10-13(17(25-26)18(20)21)23-19(29)14-8-6-11-7-9-16(24-27(11)14)22-12-4-2-3-5-15(12)28;3-2(4,5)1(6)7/h6-10,12,15,18,28H,2-5H2,1H3,(H,22,24)(H,23,29);(H,6,7)/t12-,15+;/m1./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278752
PNG
(2-[(1S,5S)- or (1R,5R)- 3,6- diazabicyclo[3.2.1]oc...)
Show SMILES Cn1cc(NC(=O)c2ccc3ccc(nn23)N2C[C@@H]3C[C@H](C2)N3)c(n1)C(F)F
Show InChI InChI=1S/C18H19F2N7O/c1-25-9-13(16(24-25)17(19)20)22-18(28)14-4-2-12-3-5-15(23-27(12)14)26-7-10-6-11(8-26)21-10/h2-5,9-11,17,21H,6-8H2,1H3,(H,22,28)/t10-,11+
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278822
PNG
(2-[(1S,5R)- or (1R,5S)- 3,6- diazabicyclo[3.2.1]oc...)
Show SMILES Cn1cc(NC(=O)c2ccc3ccc(nn23)N2C[C@@H]3C[C@H]2CNC3)c(n1)C(F)F
Show InChI InChI=1S/C19H21F2N7O/c1-26-10-14(17(25-26)18(20)21)23-19(29)15-4-2-12-3-5-16(24-28(12)15)27-9-11-6-13(27)8-22-7-11/h2-5,10-11,13,18,22H,6-9H2,1H3,(H,23,29)/t11-,13+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278737
PNG
(N-(3-chloro-1-methyl- 1H-pyrazol-4-yl)-2- [(1S,4S)...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2ccc3ccc(nn23)N2C[C@H]3CC[C@@H]2CN3)c(Cl)n1
Show InChI InChI=1S/C18H20ClN7O.C2HF3O2/c1-24-10-14(17(19)23-24)21-18(27)15-6-4-12-5-7-16(22-26(12)15)25-9-11-2-3-13(25)8-20-11;3-2(4,5)1(6)7/h4-7,10-11,13,20H,2-3,8-9H2,1H3,(H,21,27);(H,6,7)/t11-,13-;/m1./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278711
PNG
(2-(2,5- diazabicyclo[2.2.2]oct- 2-yl)-N-[1-methyl-...)
Show SMILES Cn1cc(NC(=O)c2ccc3ccc(nn23)N2CC3CCC2CN3)c(n1)C(F)(F)F
Show InChI InChI=1S/C19H20F3N7O/c1-27-10-14(17(26-27)19(20,21)22)24-18(30)15-6-4-12-5-7-16(25-29(12)15)28-9-11-2-3-13(28)8-23-11/h4-7,10-11,13,23H,2-3,8-9H2,1H3,(H,24,30)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278726
PNG
(N-(3-chloro-1-methyl- 1H-pyrazol-4-yl)-2- (1,4-dia...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2ccc3ccc(nn23)N2CCCNCC2)c(Cl)n1
Show InChI InChI=1S/C17H20ClN7O.C2HF3O2/c1-23-11-13(16(18)22-23)20-17(26)14-5-3-12-4-6-15(21-25(12)14)24-9-2-7-19-8-10-24;3-2(4,5)1(6)7/h3-6,11,19H,2,7-10H2,1H3,(H,20,26);(H,6,7)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278739
PNG
(N-(3-bromo-1-methyl- 1H-pyrazol-4-yl)-2- [(1S,4S)-...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2ccc3ccc(nn23)N2C[C@H]3CC[C@@H]2CN3)c(Br)n1
Show InChI InChI=1S/C18H20BrN7O.C2HF3O2/c1-24-10-14(17(19)23-24)21-18(27)15-6-4-12-5-7-16(22-26(12)15)25-9-11-2-3-13(25)8-20-11;3-2(4,5)1(6)7/h4-7,10-11,13,20H,2-3,8-9H2,1H3,(H,21,27);(H,6,7)/t11-,13-;/m1./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278774
PNG
(2-{[(1R,2S)-2- aminocyclohexyl]amino}- N-[4- (difl...)
Show SMILES OC(=O)C(F)(F)F.N[C@H]1CCCC[C@H]1Nc1ccc2ccc(C(=O)Nc3cscc3C(F)F)n2n1
Show InChI InChI=1S/C19H21F2N5OS.C2HF3O2/c20-18(21)12-9-28-10-15(12)24-19(27)16-7-5-11-6-8-17(25-26(11)16)23-14-4-2-1-3-13(14)22;3-2(4,5)1(6)7/h5-10,13-14,18H,1-4,22H2,(H,23,25)(H,24,27);(H,6,7)/t13-,14+;/m0./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278730
PNG
(N-(3-bromo-1-methyl- 1H-pyrazol-4-yl)-2- (2,5- dia...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2ccc3ccc(nn23)N2CC3CCC2CN3)c(Br)n1
Show InChI InChI=1S/C18H20BrN7O.C2HF3O2/c1-24-10-14(17(19)23-24)21-18(27)15-6-4-12-5-7-16(22-26(12)15)25-9-11-2-3-13(25)8-20-11;3-2(4,5)1(6)7/h4-7,10-11,13,20H,2-3,8-9H2,1H3,(H,21,27);(H,6,7)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278734
PNG
(N-(3-cyano-1-methyl- 1H-pyrazol-4-yl)-2- (2,5- dia...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2ccc3ccc(nn23)N2CC3CCC2CN3)c(n1)C#N
Show InChI InChI=1S/C19H20N8O.C2HF3O2/c1-25-11-16(15(8-20)23-25)22-19(28)17-6-4-13-5-7-18(24-27(13)17)26-10-12-2-3-14(26)9-21-12;3-2(4,5)1(6)7/h4-7,11-12,14,21H,2-3,9-10H2,1H3,(H,22,28);(H,6,7)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278746
PNG
(N-(3-cyano-1-methyl- 1H-pyrazol-4-yl)-2- [(1S,4S)-...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2ccc3ccc(nn23)N2C[C@@H]3CC[C@H]2CN3)c(n1)C#N
Show InChI InChI=1S/C19H20N8O.C2HF3O2/c1-25-11-16(15(8-20)23-25)22-19(28)17-6-4-13-5-7-18(24-27(13)17)26-10-12-2-3-14(26)9-21-12;3-2(4,5)1(6)7/h4-7,11-12,14,21H,2-3,9-10H2,1H3,(H,22,28);(H,6,7)/t12-,14-;/m0./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278807
PNG
(2-[(3R)-3- aminopiperidin-1- yl]-N-(2-cyanophenyl)...)
Show SMILES OC(=O)C(F)(F)F.N[C@@H]1CCCN(C1)c1ccc2ccc(C(=O)Nc3ccccc3C#N)n2n1
Show InChI InChI=1S/C20H20N6O.C2HF3O2/c21-12-14-4-1-2-6-17(14)23-20(27)18-9-7-16-8-10-19(24-26(16)18)25-11-3-5-15(22)13-25;3-2(4,5)1(6)7/h1-2,4,6-10,15H,3,5,11,13,22H2,(H,23,27);(H,6,7)/t15-;/m1./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278733
PNG
(N-(3-cyano-1-methyl- 1H-pyrazol-4-yl)-2- (1,4-diaz...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2ccc3ccc(nn23)N2CCCNCC2)c(n1)C#N
Show InChI InChI=1S/C18H20N8O.C2HF3O2/c1-24-12-15(14(11-19)22-24)21-18(27)16-5-3-13-4-6-17(23-26(13)16)25-9-2-7-20-8-10-25;3-2(4,5)1(6)7/h3-6,12,20H,2,7-10H2,1H3,(H,21,27);(H,6,7)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278711
PNG
(2-(2,5- diazabicyclo[2.2.2]oct- 2-yl)-N-[1-methyl-...)
Show SMILES Cn1cc(NC(=O)c2ccc3ccc(nn23)N2CC3CCC2CN3)c(n1)C(F)(F)F
Show InChI InChI=1S/C19H20F3N7O/c1-27-10-14(17(26-27)19(20,21)22)24-18(30)15-6-4-12-5-7-16(25-29(12)15)28-9-11-2-3-13(28)8-23-11/h4-7,10-11,13,23H,2-3,8-9H2,1H3,(H,24,30)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278712
PNG
(2-(5,8- diazaspiro[2.6]non-5- yl)-N-[1-methyl-3- (...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2ccc3ccc(nn23)N2CCNCC3(CC3)C2)c(n1)C(F)(F)F
Show InChI InChI=1S/C20H22F3N7O.C2HF3O2/c1-28-10-14(17(27-28)20(21,22)23)25-18(31)15-4-2-13-3-5-16(26-30(13)15)29-9-8-24-11-19(12-29)6-7-19;3-2(4,5)1(6)7/h2-5,10,24H,6-9,11-12H2,1H3,(H,25,31);(H,6,7)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278729
PNG
(N-(3-chloro-1-methyl- 1H-pyrazol-4-yl)-2- (2,5- di...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2ccc3ccc(nn23)N2CC3CCC2CN3)c(Cl)n1
Show InChI InChI=1S/C18H20ClN7O.C2HF3O2/c1-24-10-14(17(19)23-24)21-18(27)15-6-4-12-5-7-16(22-26(12)15)25-9-11-2-3-13(25)8-20-11;3-2(4,5)1(6)7/h4-7,10-11,13,20H,2-3,8-9H2,1H3,(H,21,27);(H,6,7)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278724
PNG
(N-(3-bromo-1-methyl- 1H-pyrazol-4-yl)-2- (1,4-diaz...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2ccc3ccc(nn23)N2CCCNCC2)c(Br)n1
Show InChI InChI=1S/C17H20BrN7O.C2HF3O2/c1-23-11-13(16(18)22-23)20-17(26)14-5-3-12-4-6-15(21-25(12)14)24-9-2-7-19-8-10-24;3-2(4,5)1(6)7/h3-6,11,19H,2,7-10H2,1H3,(H,20,26);(H,6,7)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278713
PNG
(2-(1,4-diazepan-1-yl)- N-[1-methyl-3- (trifluorome...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2ccc3ccc(nn23)N2CCCNCC2)c(n1)C(F)(F)F
Show InChI InChI=1S/C18H20F3N7O.C2HF3O2/c1-26-11-13(16(25-26)18(19,20)21)23-17(29)14-5-3-12-4-6-15(24-28(12)14)27-9-2-7-22-8-10-27;3-2(4,5)1(6)7/h3-6,11,22H,2,7-10H2,1H3,(H,23,29);(H,6,7)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278731
PNG
(2-{[(1R,2R)-2-amino- 3,3- difluorocyclohexyl]amino...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2ccc3ccc(N[C@@H]4CCCC(F)(F)[C@@H]4N)nn23)c(n1)C(F)F
Show InChI InChI=1S/C19H21F4N7O.C2HF3O2/c1-29-9-12(15(28-29)17(20)21)26-18(31)13-6-4-10-5-7-14(27-30(10)13)25-11-3-2-8-19(22,23)16(11)24;3-2(4,5)1(6)7/h4-7,9,11,16-17H,2-3,8,24H2,1H3,(H,25,27)(H,26,31);(H,6,7)/t11-,16-;/m1./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278738
PNG
(N-(3-bromo-1-methyl- 1H-pyrazol-4-yl)-2- [(1S,4S)-...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2ccc3ccc(nn23)N2C[C@@H]3CC[C@H]2CN3)c(Br)n1
Show InChI InChI=1S/C18H20BrN7O.C2HF3O2/c1-24-10-14(17(19)23-24)21-18(27)15-6-4-12-5-7-16(22-26(12)15)25-9-11-2-3-13(25)8-20-11;3-2(4,5)1(6)7/h4-7,10-11,13,20H,2-3,8-9H2,1H3,(H,21,27);(H,6,7)/t11-,13-;/m0./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278819
PNG
(2-[(1S,5R)- (1R,5S)- 3,6- diazabicyclo[3.2.1]oct- ...)
Show SMILES Cn1cc(NC(=O)c2ccc3ccc(nn23)N2C[C@H]3C[C@@H]2CNC3)c(n1)C(F)(F)F
Show InChI InChI=1S/C19H20F3N7O/c1-27-10-14(17(26-27)19(20,21)22)24-18(30)15-4-2-12-3-5-16(25-29(12)15)28-9-11-6-13(28)8-23-7-11/h2-5,10-11,13,23H,6-9H2,1H3,(H,24,30)/t11-,13+/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278754
PNG
(2-{[(1R,2R)-2-amino- 3,3-difluoro- cyclohexyl]amin...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2ccc3ccc(N[C@@H]4CCCC(F)(F)[C@@H]4N)nn23)c(n1)C#N
Show InChI InChI=1S/C19H20F2N8O.C2HF3O2/c1-28-10-14(13(9-22)26-28)25-18(30)15-6-4-11-5-7-16(27-29(11)15)24-12-3-2-8-19(20,21)17(12)23;3-2(4,5)1(6)7/h4-7,10,12,17H,2-3,8,23H2,1H3,(H,24,27)(H,25,30);(H,6,7)/t12-,17-;/m1./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278736
PNG
(N-(3-chloro-1-methyl- 1H-pyrazol-4-yl)-2- [(1S,4S)...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2ccc3ccc(nn23)N2C[C@@H]3CC[C@H]2CN3)c(Cl)n1
Show InChI InChI=1S/C18H20ClN7O.C2HF3O2/c1-24-10-14(17(19)23-24)21-18(27)15-6-4-12-5-7-16(22-26(12)15)25-9-11-2-3-13(25)8-20-11;3-2(4,5)1(6)7/h4-7,10-11,13,20H,2-3,8-9H2,1H3,(H,21,27);(H,6,7)/t11-,13-;/m0./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278747
PNG
(N-(3-cyano-1-methyl- 1H-pyrazol-4-yl)-2- [(1S,4S)-...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2ccc3ccc(nn23)N2C[C@H]3CC[C@@H]2CN3)c(n1)C#N
Show InChI InChI=1S/C19H20N8O.C2HF3O2/c1-25-11-16(15(8-20)23-25)22-19(28)17-6-4-13-5-7-18(24-27(13)17)26-10-12-2-3-14(26)9-21-12;3-2(4,5)1(6)7/h4-7,11-12,14,21H,2-3,9-10H2,1H3,(H,22,28);(H,6,7)/t12-,14-;/m1./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278757
PNG
(N-[3-(difluoromethyl)- 1-(1-methylethyl)-1H- pyraz...)
Show SMILES OC(=O)C(F)(F)F.CC(C)n1cc(NC(=O)c2ccc3ccc(N[C@@H]4CCCC[C@@H]4O)nn23)c(n1)C(F)F
Show InChI InChI=1S/C21H26F2N6O2.C2HF3O2/c1-12(2)28-11-15(19(27-28)20(22)23)25-21(31)16-9-7-13-8-10-18(26-29(13)16)24-14-5-3-4-6-17(14)30;3-2(4,5)1(6)7/h7-12,14,17,20,30H,3-6H2,1-2H3,(H,24,26)(H,25,31);(H,6,7)/t14-,17+;/m1./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278755
PNG
(N-(3-chloro-1-methyl- 1H-pyrazol-4-yl)-2- {[(1R,2S...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2ccc3ccc(N[C@@H]4CCCC[C@@H]4O)nn23)c(Cl)n1
Show InChI InChI=1S/C18H21ClN6O2.C2HF3O2/c1-24-10-13(17(19)23-24)21-18(27)14-8-6-11-7-9-16(22-25(11)14)20-12-4-2-3-5-15(12)26;3-2(4,5)1(6)7/h6-10,12,15,26H,2-5H2,1H3,(H,20,22)(H,21,27);(H,6,7)/t12-,15+;/m1./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278706
PNG
(2-[(1S,5S)- or (1R,5R)- 3,6- diazabicyclo[3.2.1]oc...)
Show SMILES Cn1cc(NC(=O)c2ccc3ccc(nn23)N2C[C@@H]3CN[C@@H](C3)C2)c(n1)C(F)(F)F
Show InChI InChI=1S/C19H20F3N7O/c1-27-10-14(17(26-27)19(20,21)22)24-18(30)15-4-2-13-3-5-16(25-29(13)15)28-8-11-6-12(9-28)23-7-11/h2-5,10-12,23H,6-9H2,1H3,(H,24,30)/t11-,12-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278808
PNG
(2-[(3R)- or (3S)- azepan-3- ylamino]-N-(2- cyanoph...)
Show SMILES OC(=O)C(F)(F)F.O=C(Nc1ccccc1C#N)c1ccc2ccc(N[C@@H]3CCCCNC3)nn12
Show InChI InChI=1S/C21H22N6O.C2HF3O2/c22-13-15-5-1-2-7-18(15)25-21(28)19-10-8-17-9-11-20(26-27(17)19)24-16-6-3-4-12-23-14-16;3-2(4,5)1(6)7/h1-2,5,7-11,16,23H,3-4,6,12,14H2,(H,24,26)(H,25,28);(H,6,7)/t16-;/m1./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278758
PNG
(2-(2,5- diazabicyclo[2.2.2]oct- 2-yl)-N-[4- (diflu...)
Show SMILES FC(F)c1cscc1NC(=O)c1ccc2ccc(nn12)N1CC2CCC1CN2
Show InChI InChI=1S/C19H19F2N5OS/c20-18(21)14-9-28-10-15(14)23-19(27)16-5-3-12-4-6-17(24-26(12)16)25-8-11-1-2-13(25)7-22-11/h3-6,9-11,13,18,22H,1-2,7-8H2,(H,23,27)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278782
PNG
(N-(2-cyanothiophen-3- yl)-2-[(1S,4S)- or (1R,4R)-2...)
Show SMILES OC=O.O=C(Nc1ccsc1C#N)c1ccc2ccc(nn12)N1C[C@@H]2CC[C@H]1CN2
Show InChI InChI=1S/C19H18N6OS.CH2O2/c20-9-17-15(7-8-27-17)22-19(26)16-5-3-13-4-6-18(23-25(13)16)24-11-12-1-2-14(24)10-21-12;2-1-3/h3-8,12,14,21H,1-2,10-11H2,(H,22,26);1H,(H,2,3)/t12-,14-;/m0./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278820
PNG
(2-[(1S,5R)- (1R,5S)- 3,6- diazabicyclo[3.2.1]oct- ...)
Show SMILES Cn1cc(NC(=O)c2ccc3ccc(nn23)N2C[C@@H]3C[C@H]2CNC3)c(n1)C(F)(F)F
Show InChI InChI=1S/C19H20F3N7O/c1-27-10-14(17(26-27)19(20,21)22)24-18(30)15-4-2-12-3-5-16(25-29(12)15)28-9-11-6-13(28)8-23-7-11/h2-5,10-11,13,23H,6-9H2,1H3,(H,24,30)/t11-,13+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278708
PNG
(2-{[(1R,2S)-2- hydroxycyclo- hexyl]amino}- N-[1-me...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2ccc3ccc(N[C@@H]4CCCC[C@@H]4O)nn23)c(n1)C(F)(F)F
Show InChI InChI=1S/C19H21F3N6O2.C2HF3O2/c1-27-10-13(17(26-27)19(20,21)22)24-18(30)14-8-6-11-7-9-16(25-28(11)14)23-12-4-2-3-5-15(12)29;3-2(4,5)1(6)7/h6-10,12,15,29H,2-5H2,1H3,(H,23,25)(H,24,30);(H,6,7)/t12-,15+;/m1./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278786
PNG
(N-(4-chlorothiophen-3- yl)-2-[(1S,4S)- or (1R,4R)-...)
Show SMILES OC(=O)C(F)(F)F.Clc1cscc1NC(=O)c1ccc2ccc(nn12)N1C[C@H]2CC[C@@H]1CN2
Show InChI InChI=1S/C18H18ClN5OS.C2HF3O2/c19-14-9-26-10-15(14)21-18(25)16-5-3-12-4-6-17(22-24(12)16)23-8-11-1-2-13(23)7-20-11;3-2(4,5)1(6)7/h3-6,9-11,13,20H,1-2,7-8H2,(H,21,25);(H,6,7)/t11-,13-;/m1./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278707
PNG
(2-[(1S,5S)- or (1R,5R)- 3,6- diazabicyclo[3.2.1]oc...)
Show SMILES Cn1cc(NC(=O)c2ccc3ccc(nn23)N2C[C@H]3CN[C@H](C3)C2)c(n1)C(F)(F)F
Show InChI InChI=1S/C19H20F3N7O/c1-27-10-14(17(26-27)19(20,21)22)24-18(30)15-4-2-13-3-5-16(25-29(13)15)28-8-11-6-12(9-28)23-7-11/h2-5,10-12,23H,6-9H2,1H3,(H,24,30)/t11-,12-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278776
PNG
(N-(4-cyanothiophen-3- yl)-2-(2,5- diazabicyclo[2.2...)
Show SMILES OC(=O)C(F)(F)F.O=C(Nc1cscc1C#N)c1ccc2ccc(nn12)N1CC2CCC1CN2
Show InChI InChI=1S/C19H18N6OS.C2HF3O2/c20-7-12-10-27-11-16(12)22-19(26)17-5-3-14-4-6-18(23-25(14)17)24-9-13-1-2-15(24)8-21-13;3-2(4,5)1(6)7/h3-6,10-11,13,15,21H,1-2,8-9H2,(H,22,26);(H,6,7)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278748
PNG
(2-{[(1R,2S)-2- aminocyclohexyl]amino}- N-[1-methyl...)
Show SMILES OC(=O)C(F)(F)F.Cn1ncc(NC(=O)c2ccc3ccc(N[C@@H]4CCCC[C@@H]4N)nn23)c1C(F)(F)F
Show InChI InChI=1S/C19H22F3N7O.C2HF3O2/c1-28-17(19(20,21)22)14(10-24-28)26-18(30)15-8-6-11-7-9-16(27-29(11)15)25-13-5-3-2-4-12(13)23;3-2(4,5)1(6)7/h6-10,12-13H,2-5,23H2,1H3,(H,25,27)(H,26,30);(H,6,7)/t12-,13+;/m0./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278751
PNG
(2-{[(1R,2R)-2-amino- 3,3-difluoro- cyclohexyl]amin...)
Show SMILES CC(O)=O.Cn1cc(NC(=O)c2ccc3ccc(N[C@@H]4CCCC(F)(F)[C@@H]4N)nn23)c(Cl)n1
Show InChI InChI=1S/C18H20ClF2N7O.C2H4O2/c1-27-9-12(16(19)26-27)24-17(29)13-6-4-10-5-7-14(25-28(10)13)23-11-3-2-8-18(20,21)15(11)22;1-2(3)4/h4-7,9,11,15H,2-3,8,22H2,1H3,(H,23,25)(H,24,29);1H3,(H,3,4)/t11-,15-;/m1./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278771
PNG
(2-(1,4-diazepan-1-yl)- N-[4- (difluoromethyl)thiop...)
Show SMILES OC(=O)C(F)(F)F.FC(F)c1cscc1NC(=O)c1ccc2ccc(nn12)N1CCCNCC1
Show InChI InChI=1S/C18H19F2N5OS.C2HF3O2/c19-17(20)13-10-27-11-14(13)22-18(26)15-4-2-12-3-5-16(23-25(12)15)24-8-1-6-21-7-9-24;3-2(4,5)1(6)7/h2-5,10-11,17,21H,1,6-9H2,(H,22,26);(H,6,7)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278785
PNG
(N-(4-chlorothiophen-3- yl)-2-[(1S,4S)- or (1R,4R)-...)
Show SMILES OC(=O)C(F)(F)F.Clc1cscc1NC(=O)c1ccc2ccc(nn12)N1C[C@@H]2CC[C@H]1CN2
Show InChI InChI=1S/C18H18ClN5OS.C2HF3O2/c19-14-9-26-10-15(14)21-18(25)16-5-3-12-4-6-17(22-24(12)16)23-8-11-1-2-13(23)7-20-11;3-2(4,5)1(6)7/h3-6,9-11,13,20H,1-2,7-8H2,(H,21,25);(H,6,7)/t11-,13-;/m0./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278710
PNG
(2-{[(1R,2R)-2-amino- 3,3-difluorocyclo- hexyl]amin...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2ccc3ccc(N[C@@H]4CCCC(F)(F)[C@@H]4N)nn23)c(n1)C(F)(F)F
Show InChI InChI=1S/C19H20F5N7O.C2HF3O2/c1-30-9-12(16(29-30)19(22,23)24)27-17(32)13-6-4-10-5-7-14(28-31(10)13)26-11-3-2-8-18(20,21)15(11)25;3-2(4,5)1(6)7/h4-7,9,11,15H,2-3,8,25H2,1H3,(H,26,28)(H,27,32);(H,6,7)/t11-,15-;/m1./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278770
PNG
(N-(4-cyanothiophen-3- yl)-2-(1,4-diazepan-1- yl)py...)
Show SMILES OC(=O)C(F)(F)F.O=C(Nc1cscc1C#N)c1ccc2ccc(nn12)N1CCCNCC1
Show InChI InChI=1S/C18H18N6OS.C2HF3O2/c19-10-13-11-26-12-15(13)21-18(25)16-4-2-14-3-5-17(22-24(14)16)23-8-1-6-20-7-9-23;3-2(4,5)1(6)7/h2-5,11-12,20H,1,6-9H2,(H,21,25);(H,6,7)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278781
PNG
(N-(2-bromothiophen-3- yl)-2-[(1S,4S)- or (1R,4R)-2...)
Show SMILES OC(=O)C(F)(F)F.Brc1sccc1NC(=O)c1ccc2ccc(nn12)N1C[C@H]2CC[C@@H]1CN2
Show InChI InChI=1S/C18H18BrN5OS.C2HF3O2/c19-17-14(7-8-26-17)21-18(25)15-5-3-12-4-6-16(22-24(12)15)23-10-11-1-2-13(23)9-20-11;3-2(4,5)1(6)7/h3-8,11,13,20H,1-2,9-10H2,(H,21,25);(H,6,7)/t11-,13-;/m1./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278769
PNG
(N-(2-cyanothiophen-3- yl)-2-(1,4-diazepan-1- yl)py...)
Show SMILES OC(=O)C(F)(F)F.O=C(Nc1ccsc1C#N)c1ccc2ccc(nn12)N1CCCNCC1
Show InChI InChI=1S/C18H18N6OS.C2HF3O2/c19-12-16-14(6-11-26-16)21-18(25)15-4-2-13-3-5-17(22-24(13)15)23-9-1-7-20-8-10-23;3-2(4,5)1(6)7/h2-6,11,20H,1,7-10H2,(H,21,25);(H,6,7)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278815
PNG
(2-{[1R,2S)-2- aminocyclohexyl] amino}-N-[2- (trifl...)
Show SMILES OC(=O)C(F)(F)F.N[C@H]1CCCC[C@H]1Nc1ccc2ccc(C(=O)Nc3ccsc3C(F)(F)F)n2n1
Show InChI InChI=1S/C19H20F3N5OS.C2HF3O2/c20-19(21,22)17-14(9-10-29-17)25-18(28)15-7-5-11-6-8-16(26-27(11)15)24-13-4-2-1-3-12(13)23;3-2(4,5)1(6)7/h5-10,12-13H,1-4,23H2,(H,24,26)(H,25,28);(H,6,7)/t12-,13+;/m0./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278735
PNG
(2-{[(1R,2R)-2-amino- 3,3-difluoro- cyclohexyl]amin...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2ccc3ccc(N[C@@H]4CCCC(F)(F)[C@@H]4N)nn23)c(Br)n1
Show InChI InChI=1S/C18H20BrF2N7O.C2HF3O2/c1-27-9-12(16(19)26-27)24-17(29)13-6-4-10-5-7-14(25-28(10)13)23-11-3-2-8-18(20,21)15(11)22;3-2(4,5)1(6)7/h4-7,9,11,15H,2-3,8,22H2,1H3,(H,23,25)(H,24,29);(H,6,7)/t11-,15-;/m1./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278784
PNG
(N-(4-chlorothiophen-3- yl)-2-(1,4-diazepan-1- yl)p...)
Show SMILES OC(=O)C(F)(F)F.Clc1cscc1NC(=O)c1ccc2ccc(nn12)N1CCCNCC1
Show InChI InChI=1S/C17H18ClN5OS.C2HF3O2/c18-13-10-25-11-14(13)20-17(24)15-4-2-12-3-5-16(21-23(12)15)22-8-1-6-19-7-9-22;3-2(4,5)1(6)7/h2-5,10-11,19H,1,6-9H2,(H,20,24);(H,6,7)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278791
PNG
(2-{[(1R,2R)-2-amino- 3,3-difluoro- cyclohexyl]amin...)
Show SMILES OC(=O)C(F)(F)F.N[C@@H]1[C@@H](CCCC1(F)F)Nc1ccc2ccc(C(=O)Nc3cscc3C#N)n2n1
Show InChI InChI=1S/C19H18F2N6OS.C2HF3O2/c20-19(21)7-1-2-13(17(19)23)24-16-6-4-12-3-5-15(27(12)26-16)18(28)25-14-10-29-9-11(14)8-22;3-2(4,5)1(6)7/h3-6,9-10,13,17H,1-2,7,23H2,(H,24,26)(H,25,28);(H,6,7)/t13-,17-;/m1./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278783
PNG
(N-(2-cyanothiophen-3- yl)-2-[(1S,4S)- or (1R,4R)-2...)
Show SMILES OC=O.O=C(Nc1ccsc1C#N)c1ccc2ccc(nn12)N1C[C@H]2CC[C@@H]1CN2
Show InChI InChI=1S/C19H18N6OS.CH2O2/c20-9-17-15(7-8-27-17)22-19(26)16-5-3-13-4-6-18(23-25(13)16)24-11-12-1-2-14(24)10-21-12;2-1-3/h3-8,12,14,21H,1-2,10-11H2,(H,22,26);1H,(H,2,3)/t12-,14-;/m1./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278764
PNG
(N-(4-bromothiophen-3- yl)-2-(2,5- diazabicyclo[2.2...)
Show SMILES OC(=O)C(F)(F)F.Brc1cscc1NC(=O)c1ccc2ccc(nn12)N1CC2CCC1CN2
Show InChI InChI=1S/C18H18BrN5OS.C2HF3O2/c19-14-9-26-10-15(14)21-18(25)16-5-3-12-4-6-17(22-24(12)16)23-8-11-1-2-13(23)7-20-11;3-2(4,5)1(6)7/h3-6,9-11,13,20H,1-2,7-8H2,(H,21,25);(H,6,7)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278772
PNG
(N-(2-chlorothiophen-3- yl)-2-(2,5- diazabicyclo[2....)
Show SMILES OC(=O)C(F)(F)F.Clc1sccc1NC(=O)c1ccc2ccc(nn12)N1CC2CCC1CN2
Show InChI InChI=1S/C18H18ClN5OS.C2HF3O2/c19-17-14(7-8-26-17)21-18(25)15-5-3-12-4-6-16(22-24(12)15)23-10-11-1-2-13(23)9-20-11;3-2(4,5)1(6)7/h3-8,11,13,20H,1-2,9-10H2,(H,21,25);(H,6,7)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278802
PNG
(N-(2- cyanophenyl)-2- (2,5- diazabicyclo[2.2.2] oc...)
Show SMILES OC(=O)C(F)(F)F.O=C(Nc1ccccc1C#N)c1ccc2ccc(nn12)N1CC2CCC1CN2
Show InChI InChI=1S/C21H20N6O.C2HF3O2/c22-11-14-3-1-2-4-18(14)24-21(28)19-9-7-16-8-10-20(25-27(16)19)26-13-15-5-6-17(26)12-23-15;3-2(4,5)1(6)7/h1-4,7-10,15,17,23H,5-6,12-13H2,(H,24,28);(H,6,7)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278811
PNG
(2-{[(1R,2S)-2- aminocyclohexyl] amino}-N-[2- (difl...)
Show SMILES OC(=O)C(F)(F)F.N[C@H]1CCCC[C@H]1Nc1ccc2ccc(C(=O)Nc3ccccc3C(F)F)n2n1
Show InChI InChI=1S/C21H23F2N5O.C2HF3O2/c22-20(23)14-5-1-3-7-16(14)26-21(29)18-11-9-13-10-12-19(27-28(13)18)25-17-8-4-2-6-15(17)24;3-2(4,5)1(6)7/h1,3,5,7,9-12,15,17,20H,2,4,6,8,24H2,(H,25,27)(H,26,29);(H,6,7)/t15-,17+;/m0./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278800
PNG
(2-{[(1R,2R)-2-amino- 3,3- difluorocyclohexyl] amin...)
Show SMILES OC(=O)C(F)(F)F.N[C@@H]1[C@@H](CCCC1(F)F)Nc1ccc2ccc(C(=O)Nc3ccsc3C#N)n2n1
Show InChI InChI=1S/C19H18F2N6OS.C2HF3O2/c20-19(21)8-1-2-13(17(19)23)24-16-6-4-11-3-5-14(27(11)26-16)18(28)25-12-7-9-29-15(12)10-22;3-2(4,5)1(6)7/h3-7,9,13,17H,1-2,8,23H2,(H,24,26)(H,25,28);(H,6,7)/t13-,17-;/m1./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278762
PNG
(N-(4-bromothiophen-3- yl)-2-(1,4-diazepan-1- yl)py...)
Show SMILES OC(=O)C(F)(F)F.Brc1cscc1NC(=O)c1ccc2ccc(nn12)N1CCCNCC1
Show InChI InChI=1S/C17H18BrN5OS.C2HF3O2/c18-13-10-25-11-14(13)20-17(24)15-4-2-12-3-5-16(21-23(12)15)22-8-1-6-19-7-9-22;3-2(4,5)1(6)7/h2-5,10-11,19H,1,6-9H2,(H,20,24);(H,6,7)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278801
PNG
(N-(2- cyanophenyl)-2- piperazin-1- ylpyrrolo[1,2- ...)
Show SMILES OC(=O)C(F)(F)F.O=C(Nc1ccccc1C#N)c1ccc2ccc(nn12)N1CCNCC1
Show InChI InChI=1S/C19H18N6O.C2HF3O2/c20-13-14-3-1-2-4-16(14)22-19(26)17-7-5-15-6-8-18(23-25(15)17)24-11-9-21-10-12-24;3-2(4,5)1(6)7/h1-8,21H,9-12H2,(H,22,26);(H,6,7)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278766
PNG
(N-(2-chlorophenyl)-2- (2,5- diazabicyclo[2.2.2]oct...)
Show SMILES OC(=O)C(F)(F)F.Clc1ccccc1NC(=O)c1ccc2ccc(nn12)N1CC2CCC1CN2
Show InChI InChI=1S/C20H20ClN5O.C2HF3O2/c21-16-3-1-2-4-17(16)23-20(27)18-9-7-14-8-10-19(24-26(14)18)25-12-13-5-6-15(25)11-22-13;3-2(4,5)1(6)7/h1-4,7-10,13,15,22H,5-6,11-12H2,(H,23,27);(H,6,7)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278768
PNG
(N-(2-chlorothiophen-3- yl)-2-(1,4-diazepan-1- yl)p...)
Show SMILES OC(=O)C(F)(F)F.Clc1sccc1NC(=O)c1ccc2ccc(nn12)N1CCCNCC1
Show InChI InChI=1S/C17H18ClN5OS.C2HF3O2/c18-16-13(6-11-25-16)20-17(24)14-4-2-12-3-5-15(21-23(12)14)22-9-1-7-19-8-10-22;3-2(4,5)1(6)7/h2-6,11,19H,1,7-10H2,(H,20,24);(H,6,7)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278756
PNG
(N-[1-tert-butyl-3- (difluoromethyl)-1H- pyrazol-4-...)
Show SMILES OC(=O)C(F)(F)F.CC(C)(C)n1cc(NC(=O)c2ccc3ccc(N[C@@H]4CCCC[C@@H]4O)nn23)c(n1)C(F)F
Show InChI InChI=1S/C22H28F2N6O2.C2HF3O2/c1-22(2,3)29-12-15(19(28-29)20(23)24)26-21(32)16-10-8-13-9-11-18(27-30(13)16)25-14-6-4-5-7-17(14)31;3-2(4,5)1(6)7/h8-12,14,17,20,31H,4-7H2,1-3H3,(H,25,27)(H,26,32);(H,6,7)/t14-,17+;/m1./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278780
PNG
(N-(2-bromothiophen-3- yl)-2-[(1S,4S)- or (1R,4R)-2...)
Show SMILES OC(=O)C(F)(F)F.Brc1sccc1NC(=O)c1ccc2ccc(nn12)N1C[C@@H]2CC[C@H]1CN2
Show InChI InChI=1S/C18H18BrN5OS.C2HF3O2/c19-17-14(7-8-26-17)21-18(25)15-5-3-12-4-6-16(22-24(12)15)23-10-11-1-2-13(23)9-20-11;3-2(4,5)1(6)7/h3-8,11,13,20H,1-2,9-10H2,(H,21,25);(H,6,7)/t11-,13-;/m0./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278798
PNG
(2-{[(1R,2R)-2-amino- 3,3-difluoro- cyclohexyl]amin...)
Show SMILES OC(=O)C(F)(F)F.N[C@@H]1[C@@H](CCCC1(F)F)Nc1ccc2ccc(C(=O)Nc3cscc3C(F)F)n2n1
Show InChI InChI=1S/C19H19F4N5OS.C2HF3O2/c20-17(21)11-8-30-9-13(11)26-18(29)14-5-3-10-4-6-15(27-28(10)14)25-12-2-1-7-19(22,23)16(12)24;3-2(4,5)1(6)7/h3-6,8-9,12,16-17H,1-2,7,24H2,(H,25,27)(H,26,29);(H,6,7)/t12-,16-;/m1./s1
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n/an/a 753n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278803
PNG
(N-(2- cyanophenyl)-2- (5,8- diazaspiro[2.6]non- 5-...)
Show SMILES OC(=O)C(F)(F)F.O=C(Nc1ccccc1C#N)c1ccc2ccc(nn12)N1CCNCC2(CC2)C1
Show InChI InChI=1S/C22H22N6O.C2HF3O2/c23-13-16-3-1-2-4-18(16)25-21(29)19-7-5-17-6-8-20(26-28(17)19)27-12-11-24-14-22(15-27)9-10-22;3-2(4,5)1(6)7/h1-8,24H,9-12,14-15H2,(H,25,29);(H,6,7)
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n/an/a 766n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278810
PNG
(2-{[(1R,2R)-2- amino-3,3- difluorocyclohexyl] amin...)
Show SMILES OC(=O)C(F)(F)F.N[C@@H]1[C@@H](CCCC1(F)F)Nc1ccc2ccc(C(=O)Nc3ccccc3C#N)n2n1
Show InChI InChI=1S/C21H20F2N6O.C2HF3O2/c22-21(23)11-3-6-16(19(21)25)26-18-10-8-14-7-9-17(29(14)28-18)20(30)27-15-5-2-1-4-13(15)12-24;3-2(4,5)1(6)7/h1-2,4-5,7-10,16,19H,3,6,11,25H2,(H,26,28)(H,27,30);(H,6,7)/t16-,19-;/m1./s1
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n/an/a 825n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278761
PNG
(N-(2-chlorophenyl)-2- (1,4-diazepan-1- yl)pyrrolo[...)
Show SMILES OC(=O)C(F)(F)F.Clc1ccccc1NC(=O)c1ccc2ccc(nn12)N1CCCNCC1
Show InChI InChI=1S/C19H20ClN5O.C2HF3O2/c20-15-4-1-2-5-16(15)22-19(26)17-8-6-14-7-9-18(23-25(14)17)24-12-3-10-21-11-13-24;3-2(4,5)1(6)7/h1-2,4-9,21H,3,10-13H2,(H,22,26);(H,6,7)
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n/an/a 1.20E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278812
PNG
(2-[(1S,4S)- or (1R,4R)- 2,5- diazabicyclo[2.2.2]oc...)
Show SMILES OC(=O)C(F)(F)F.FC(F)(F)c1sccc1NC(=O)c1ccc2ccc(nn12)N1C[C@@H]2CC[C@H]1CN2
Show InChI InChI=1S/C19H18F3N5OS.C2HF3O2/c20-19(21,22)17-14(7-8-29-17)24-18(28)15-5-3-12-4-6-16(25-27(12)15)26-10-11-1-2-13(26)9-23-11;3-2(4,5)1(6)7/h3-8,11,13,23H,1-2,9-10H2,(H,24,28);(H,6,7)/t11-,13-;/m0./s1
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n/an/a 1.22E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278778
PNG
(N-(2-bromothiophen-3- yl)-2-(1,4-diazepan-1- yl)py...)
Show SMILES OC(=O)C(F)(F)F.Brc1sccc1NC(=O)c1ccc2ccc(nn12)N1CCCNCC1
Show InChI InChI=1S/C17H18BrN5OS.C2HF3O2/c18-16-13(6-11-25-16)20-17(24)14-4-2-12-3-5-15(21-23(12)14)22-9-1-7-19-8-10-22;3-2(4,5)1(6)7/h2-6,11,19H,1,7-10H2,(H,20,24);(H,6,7)
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n/an/a 1.32E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278799
PNG
(N-(2-cyanothiophen-3- yl)-2-{[(1R,2S)-2- hydroxycy...)
Show SMILES OC(=O)C(F)(F)F.O[C@H]1CCCC[C@H]1Nc1ccc2ccc(C(=O)Nc3ccsc3C#N)n2n1
Show InChI InChI=1S/C19H19N5O2S.C2HF3O2/c20-11-17-14(9-10-27-17)22-19(26)15-7-5-12-6-8-18(23-24(12)15)21-13-3-1-2-4-16(13)25;3-2(4,5)1(6)7/h5-10,13,16,25H,1-4H2,(H,21,23)(H,22,26);(H,6,7)/t13-,16+;/m1./s1
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n/an/a 1.37E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278763
PNG
(N-(2-bromophenyl)-2- (2,5- diazabicyclo[2.2.2]oct-...)
Show SMILES OC(=O)C(F)(F)F.Brc1ccccc1NC(=O)c1ccc2ccc(nn12)N1CC2CCC1CN2
Show InChI InChI=1S/C20H20BrN5O.C2HF3O2/c21-16-3-1-2-4-17(16)23-20(27)18-9-7-14-8-10-19(24-26(14)18)25-12-13-5-6-15(25)11-22-13;3-2(4,5)1(6)7/h1-4,7-10,13,15,22H,5-6,11-12H2,(H,23,27);(H,6,7)
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n/an/a 1.67E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278813
PNG
(2-[(1S,4S)- or (1R,4R)- 2,5- diazabicyclo[2.2.2]oc...)
Show SMILES OC(=O)C(F)(F)F.FC(F)(F)c1sccc1NC(=O)c1ccc2ccc(nn12)N1C[C@H]2CC[C@@H]1CN2
Show InChI InChI=1S/C19H18F3N5OS.C2HF3O2/c20-19(21,22)17-14(7-8-29-17)24-18(28)15-5-3-12-4-6-16(25-27(12)15)26-10-11-1-2-13(26)9-23-11;3-2(4,5)1(6)7/h3-8,11,13,23H,1-2,9-10H2,(H,24,28);(H,6,7)/t11-,13-;/m1./s1
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n/an/a 1.77E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278804
PNG
(N-(2- cyanophenyl)-2- {[(1R,2S)-2- hydroxycyclohex...)
Show SMILES OC(=O)C(F)(F)F.O[C@H]1CCCC[C@H]1Nc1ccc2ccc(C(=O)Nc3ccccc3C#N)n2n1
Show InChI InChI=1S/C21H21N5O2.C2HF3O2/c22-13-14-5-1-2-6-16(14)24-21(28)18-11-9-15-10-12-20(25-26(15)18)23-17-7-3-4-8-19(17)27;3-2(4,5)1(6)7/h1-2,5-6,9-12,17,19,27H,3-4,7-8H2,(H,23,25)(H,24,28);(H,6,7)/t17-,19+;/m1./s1
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n/an/a 1.86E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278792
PNG
(2-{[(1R,2R)-2-amino- 3,3-difluoro- cyclohexyl]amin...)
Show SMILES OC(=O)C(F)(F)F.N[C@@H]1[C@@H](CCCC1(F)F)Nc1ccc2ccc(C(=O)Nc3ccsc3Cl)n2n1
Show InChI InChI=1S/C18H18ClF2N5OS.C2HF3O2/c19-16-12(7-9-28-16)24-17(27)13-5-3-10-4-6-14(25-26(10)13)23-11-2-1-8-18(20,21)15(11)22;3-2(4,5)1(6)7/h3-7,9,11,15H,1-2,8,22H2,(H,23,25)(H,24,27);(H,6,7)/t11-,15-;/m1./s1
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n/an/a 1.92E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278814
PNG
(2-(1,4-diazepan-1-yl)- N-[2- (trifluoromethyl)thio...)
Show SMILES OC(=O)C(F)(F)F.FC(F)(F)c1sccc1NC(=O)c1ccc2ccc(nn12)N1CCCNCC1
Show InChI InChI=1S/C18H18F3N5OS.C2HF3O2/c19-18(20,21)16-13(6-11-28-16)23-17(27)14-4-2-12-3-5-15(24-26(12)14)25-9-1-7-22-8-10-25;3-2(4,5)1(6)7/h2-6,11,22H,1,7-10H2,(H,23,27);(H,6,7)
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n/an/a 2.02E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278794
PNG
(2-{[(1R,2R)-2-amino- 3,3-difluoro- cyclohexyl]amin...)
Show SMILES OC(=O)C(F)(F)F.N[C@@H]1[C@@H](CCCC1(F)F)Nc1ccc2ccc(C(=O)Nc3ccccc3Cl)n2n1
Show InChI InChI=1S/C20H20ClF2N5O.C2HF3O2/c21-13-4-1-2-5-14(13)26-19(29)16-9-7-12-8-10-17(27-28(12)16)25-15-6-3-11-20(22,23)18(15)24;3-2(4,5)1(6)7/h1-2,4-5,7-10,15,18H,3,6,11,24H2,(H,25,27)(H,26,29);(H,6,7)/t15-,18-;/m1./s1
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n/an/a 2.06E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278789
PNG
(2-{[(1R,2R)-2-amino- 3,3-difluoro- cyclohexyl]amin...)
Show SMILES CC(O)=O.N[C@@H]1[C@@H](CCCC1(F)F)Nc1ccc2ccc(C(=O)Nc3cscc3Cl)n2n1
Show InChI InChI=1S/C18H18ClF2N5OS.C2H4O2/c19-11-8-28-9-13(11)24-17(27)14-5-3-10-4-6-15(25-26(10)14)23-12-2-1-7-18(20,21)16(12)22;1-2(3)4/h3-6,8-9,12,16H,1-2,7,22H2,(H,23,25)(H,24,27);1H3,(H,3,4)/t12-,16-;/m1./s1
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n/an/a 2.17E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278816
PNG
(2-{[(1R,2R)-2-amino- 3,3- difluorocyclohexyyl] ami...)
Show SMILES OC(=O)C(F)(F)F.N[C@@H]1[C@@H](CCCC1(F)F)Nc1ccc2ccc(C(=O)Nc3ccsc3C(F)(F)F)n2n1
Show InChI InChI=1S/C19H18F5N5OS.C2HF3O2/c20-18(21)8-1-2-11(15(18)25)26-14-6-4-10-3-5-13(29(10)28-14)17(30)27-12-7-9-31-16(12)19(22,23)24;3-2(4,5)1(6)7/h3-7,9,11,15H,1-2,8,25H2,(H,26,28)(H,27,30);(H,6,7)/t11-,15-;/m1./s1
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n/an/a 2.99E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278759
PNG
(N-(2-bromophenyl)-2- (1,4-diazepan-1- yl)pyrrolo[1...)
Show SMILES OC(=O)C(F)(F)F.Brc1ccccc1NC(=O)c1ccc2ccc(nn12)N1CCCNCC1
Show InChI InChI=1S/C19H20BrN5O.C2HF3O2/c20-15-4-1-2-5-16(15)22-19(26)17-8-6-14-7-9-18(23-25(14)17)24-12-3-10-21-11-13-24;3-2(4,5)1(6)7/h1-2,4-9,21H,3,10-13H2,(H,22,26);(H,6,7)
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n/an/a 3.96E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278788
PNG
(2-{[(1R,2R)-2-amino- 3,3-difluoro- cyclohexyl]amin...)
Show SMILES OC(=O)C(F)(F)F.N[C@@H]1[C@@H](CCCC1(F)F)Nc1ccc2ccc(C(=O)Nc3ccsc3Br)n2n1
Show InChI InChI=1S/C18H18BrF2N5OS.C2HF3O2/c19-16-12(7-9-28-16)24-17(27)13-5-3-10-4-6-14(25-26(10)13)23-11-2-1-8-18(20,21)15(11)22;3-2(4,5)1(6)7/h3-7,9,11,15H,1-2,8,22H2,(H,23,25)(H,24,27);(H,6,7)/t11-,15-;/m1./s1
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n/an/a 5.24E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278796
PNG
(2-{[(1R,2R)-2-amino- 3,3-difluoro- cyclohexyl]amin...)
Show SMILES OC(=O)C(F)(F)F.N[C@@H]1[C@@H](CCCC1(F)F)Nc1ccc2ccc(C(=O)Nc3ccccc3Br)n2n1
Show InChI InChI=1S/C20H20BrF2N5O.C2HF3O2/c21-13-4-1-2-5-14(13)26-19(29)16-9-7-12-8-10-17(27-28(12)16)25-15-6-3-11-20(22,23)18(15)24;3-2(4,5)1(6)7/h1-2,4-5,7-10,15,18H,3,6,11,24H2,(H,25,27)(H,26,29);(H,6,7)/t15-,18-;/m1./s1
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n/an/a 5.63E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278797
PNG
(N-(2-bromophenyl)-2- {[(1R,2S)-2- hydroxycyclohexy...)
Show SMILES OC(=O)C(F)(F)F.O[C@H]1CCCC[C@H]1Nc1ccc2ccc(C(=O)Nc3ccccc3Br)n2n1
Show InChI InChI=1S/C20H21BrN4O2.C2HF3O2/c21-14-5-1-2-6-15(14)23-20(27)17-11-9-13-10-12-19(24-25(13)17)22-16-7-3-4-8-18(16)26;3-2(4,5)1(6)7/h1-2,5-6,9-12,16,18,26H,3-4,7-8H2,(H,22,24)(H,23,27);(H,6,7)/t16-,18+;/m1./s1
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n/an/a 5.86E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278790
PNG
(2-{[(1R,2R)-2-amino- 3,3-difluoro- cyclohexyl]amin...)
Show SMILES OC(=O)C(F)(F)F.N[C@@H]1[C@@H](CCCC1(F)F)Nc1ccc2ccc(C(=O)Nc3cscc3Br)n2n1
Show InChI InChI=1S/C18H18BrF2N5OS.C2HF3O2/c19-11-8-28-9-13(11)24-17(27)14-5-3-10-4-6-15(25-26(10)14)23-12-2-1-7-18(20,21)16(12)22;3-2(4,5)1(6)7/h3-6,8-9,12,16H,1-2,7,22H2,(H,23,25)(H,24,27);(H,6,7)/t12-,16-;/m1./s1
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n/an/a 6.16E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278793
PNG
(N-(2-chlorothiophen-3- yl)-2-{[(1R,2S)-2- hydroxyc...)
Show SMILES O[C@H]1CCCC[C@H]1Nc1ccc2ccc(C(=O)Nc3ccsc3Cl)n2n1
Show InChI InChI=1S/C18H19ClN4O2S/c19-17-13(9-10-26-17)21-18(25)14-7-5-11-6-8-16(22-23(11)14)20-12-3-1-2-4-15(12)24/h5-10,12,15,24H,1-4H2,(H,20,22)(H,21,25)/t12-,15+/m1/s1
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n/an/a 6.37E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278795
PNG
(N-(2-chlorophenyl)-2- {[(1R,2S)-2- hydroxycyclohex...)
Show SMILES OC(=O)C(F)(F)F.O[C@H]1CCCC[C@H]1Nc1ccc2ccc(C(=O)Nc3ccccc3Cl)n2n1
Show InChI InChI=1S/C20H21ClN4O2.C2HF3O2/c21-14-5-1-2-6-15(14)23-20(27)17-11-9-13-10-12-19(24-25(13)17)22-16-7-3-4-8-18(16)26;3-2(4,5)1(6)7/h1-2,5-6,9-12,16,18,26H,3-4,7-8H2,(H,22,24)(H,23,27);(H,6,7)/t16-,18+;/m1./s1
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n/an/a 6.84E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278817
PNG
(2-{[(1R,2R)-2-amino- 3,3- difluorocyclohexyl] amin...)
Show SMILES OC(=O)C(F)(F)F.N[C@@H]1[C@@H](CCCC1(F)F)Nc1ccc2ccc(C(=O)Nc3ccccc3C(F)F)n2n1
Show InChI InChI=1S/C21H21F4N5O.C2HF3O2/c22-19(23)13-4-1-2-5-14(13)28-20(31)16-9-7-12-8-10-17(29-30(12)16)27-15-6-3-11-21(24,25)18(15)26;3-2(4,5)1(6)7/h1-2,4-5,7-10,15,18-19H,3,6,11,26H2,(H,27,29)(H,28,31);(H,6,7)/t15-,18-;/m1./s1
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n/an/a 7.39E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040798 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%