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Patent code US10040802

Compile Data Set for Download or QSAR
Found 109 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278845
PNG
(2[(3R)-3- aminopiperidin-1-yl] N-[3-(difluoromethy...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2csc3ncc(nc23)N2CCC[C@@H](N)C2)c(n1)C(F)F
Show InChI InChI=1S/C17H19F2N7OS.C2HF3O2/c1-25-7-11(14(24-25)15(18)19)22-16(27)10-8-28-17-13(10)23-12(5-21-17)26-4-2-3-9(20)6-26;3-2(4,5)1(6)7/h5,7-9,15H,2-4,6,20H2,1H3,(H,22,27);(H,6,7)/t9-;/m1./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278846
PNG
(2-{[(1R,2S)-2- aminocyclohexyl]amino}- N-[3-(diflu...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2csc3ncc(N[C@@H]4CCCC[C@@H]4N)nc23)c(n1)C(F)F
Show InChI InChI=1S/C18H21F2N7OS.C2HF3O2/c1-27-7-12(15(26-27)16(19)20)24-17(28)9-8-29-18-14(9)25-13(6-22-18)23-11-5-3-2-4-10(11)21;3-2(4,5)1(6)7/h6-8,10-11,16H,2-5,21H2,1H3,(H,23,25)(H,24,28);(H,6,7)/t10-,11+;/m0./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278854
PNG
(2-[(3S)- or (3R)- azepan-3-ylamino]-N- [3-(difluor...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2csc3ncc(N[C@@H]4CCCCNC4)nc23)c(n1)C(F)F
Show InChI InChI=1S/C18H21F2N7OS.C2HF3O2/c1-27-8-12(15(26-27)16(19)20)24-17(28)11-9-29-18-14(11)25-13(7-22-18)23-10-4-2-3-5-21-6-10;3-2(4,5)1(6)7/h7-10,16,21H,2-6H2,1H3,(H,23,25)(H,24,28);(H,6,7)/t10-;/m1./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278856
PNG
(2-{[(1R,2S)-2- aminocyclohexyl]amino}- N-(3-chloro...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2csc3ncc(N[C@@H]4CCCC[C@@H]4N)nc23)c(Cl)n1
Show InChI InChI=1S/C17H20ClN7OS.C2HF3O2/c1-25-7-12(15(18)24-25)22-16(26)9-8-27-17-14(9)23-13(6-20-17)21-11-5-3-2-4-10(11)19;3-2(4,5)1(6)7/h6-8,10-11H,2-5,19H2,1H3,(H,21,23)(H,22,26);(H,6,7)/t10-,11+;/m0./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM50130660
PNG
(CHEMBL3634509 | US10040802, Example 32)
Show SMILES Cn1cc(NC(=O)c2csc3ncc(N[C@@H]4CCCNC4)nc23)c(n1)C(F)F
Show InChI InChI=1S/C17H19F2N7OS/c1-26-7-11(14(25-26)15(18)19)23-16(27)10-8-28-17-13(10)24-12(6-21-17)22-9-3-2-4-20-5-9/h6-9,15,20H,2-5H2,1H3,(H,22,24)(H,23,27)/t9-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278858
PNG
(2-{[(1R,2S)-2- aminocyclohexyl]amino}- N-(3-cyano-...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2csc3ncc(N[C@@H]4CCCC[C@@H]4N)nc23)c(n1)C#N
Show InChI InChI=1S/C18H20N8OS.C2HF3O2/c1-26-8-14(13(6-19)25-26)23-17(27)10-9-28-18-16(10)24-15(7-21-18)22-12-5-3-2-4-11(12)20;3-2(4,5)1(6)7/h7-9,11-12H,2-5,20H2,1H3,(H,22,24)(H,23,27);(H,6,7)/t11-,12+;/m0./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278878
PNG
(2-{[(1R,2S)-2-amino- cyclohexyl]amino}- N-(4-cyano...)
Show SMILES OC(=O)C(F)(F)F.N[C@H]1CCCC[C@H]1Nc1cnc2scc(C(=O)Nc3cscc3C#N)c2n1
Show InChI InChI=1S/C18H18N6OS2.C2HF3O2/c19-5-10-7-26-9-14(10)23-17(25)11-8-27-18-16(11)24-15(6-21-18)22-13-4-2-1-3-12(13)20;3-2(4,5)1(6)7/h6-9,12-13H,1-4,20H2,(H,22,24)(H,23,25);(H,6,7)/t12-,13+;/m0./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278865
PNG
(2-(3,8- diazabicyclo[3.2.1] oct-8-yl)-N-[3- (diflu...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2csc3ncc(nc23)N2C3CCC2CNC3)c(n1)C(F)F
Show InChI InChI=1S/C18H19F2N7OS.C2HF3O2/c1-26-7-12(15(25-26)16(19)20)23-17(28)11-8-29-18-14(11)24-13(6-22-18)27-9-2-3-10(27)5-21-4-9;3-2(4,5)1(6)7/h6-10,16,21H,2-5H2,1H3,(H,23,28);(H,6,7)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278898
PNG
(2-{[(1R,2S)-2-amino- cyclohexyl]amino}- N-(2-(cyan...)
Show SMILES OC(=O)C(F)(F)F.N[C@H]1CCCC[C@H]1Nc1cnc2scc(C(=O)Nc3ccsc3C#N)c2n1
Show InChI InChI=1S/C18H18N6OS2.C2HF3O2/c19-7-14-13(5-6-26-14)23-17(25)10-9-27-18-16(10)24-15(8-21-18)22-12-4-2-1-3-11(12)20;3-2(4,5)1(6)7/h5-6,8-9,11-12H,1-4,20H2,(H,22,24)(H,23,25);(H,6,7)/t11-,12+;/m0./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278915
PNG
(2-{[(1R,2S)-2- aminocyclohexyl]- amino}-N-(2- cyan...)
Show SMILES OC(=O)C(F)(F)F.N[C@H]1CCCC[C@H]1Nc1cnc2scc(C(=O)Nc3ccccc3C#N)c2n1
Show InChI InChI=1S/C20H20N6OS.C2HF3O2/c21-9-12-5-1-3-7-15(12)25-19(27)13-11-28-20-18(13)26-17(10-23-20)24-16-8-4-2-6-14(16)22;3-2(4,5)1(6)7/h1,3,5,7,10-11,14,16H,2,4,6,8,22H2,(H,24,26)(H,25,27);(H,6,7)/t14-,16+;/m0./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278861
PNG
(2-(3,8- diazabicyclo[3.2.1] oct-3-yl)-N-[3- (diflu...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2csc3ncc(nc23)N2CC3CCC(C2)N3)c(n1)C(F)F
Show InChI InChI=1S/C18H19F2N7OS.C2HF3O2/c1-26-7-12(15(25-26)16(19)20)23-17(28)11-8-29-18-14(11)24-13(4-21-18)27-5-9-2-3-10(6-27)22-9;3-2(4,5)1(6)7/h4,7-10,16,22H,2-3,5-6H2,1H3,(H,23,28);(H,6,7)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278851
PNG
(2-{[(1R,2S)-2- aminocyclohexyl] amino}-N-(3-bromo-...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2csc3ncc(N[C@@H]4CCCC[C@@H]4N)nc23)c(Br)n1
Show InChI InChI=1S/C17H20BrN7OS.C2HF3O2/c1-25-7-12(15(18)24-25)22-16(26)9-8-27-17-14(9)23-13(6-20-17)21-11-5-3-2-4-10(11)19;3-2(4,5)1(6)7/h6-8,10-11H,2-5,19H2,1H3,(H,21,23)(H,22,26);(H,6,7)/t10-,11+;/m0./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278859
PNG
(2-[(3S)- or (3R)- azepan-3-ylamino]-N- [1-methyl-3...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2csc3ncc(N[C@@H]4CCCCNC4)nc23)c(n1)C(F)(F)F
Show InChI InChI=1S/C18H20F3N7OS.C2HF3O2/c1-28-8-12(15(27-28)18(19,20)21)25-16(29)11-9-30-17-14(11)26-13(7-23-17)24-10-4-2-3-5-22-6-10;3-2(4,5)1(6)7/h7-10,22H,2-6H2,1H3,(H,24,26)(H,25,29);(H,6,7)/t10-;/m1./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278874
PNG
(2-{[(1R,2S)-2-amino- cyclohexyl]amino}- N-(4-bromo...)
Show SMILES OC(=O)C(F)(F)F.N[C@H]1CCCC[C@H]1Nc1cnc2scc(C(=O)Nc3cscc3Br)c2n1
Show InChI InChI=1S/C17H18BrN5OS2.C2HF3O2/c18-10-7-25-8-13(10)22-16(24)9-6-26-17-15(9)23-14(5-20-17)21-12-4-2-1-3-11(12)19;3-2(4,5)1(6)7/h5-8,11-12H,1-4,19H2,(H,21,23)(H,22,24);(H,6,7)/t11-,12+;/m0./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278877
PNG
(2-{[(1R,2S)-2-amino- cyclohexyl]amino}- N-(2-chlor...)
Show SMILES OC(=O)C(F)(F)F.N[C@H]1CCCC[C@H]1Nc1cnc2scc(C(=O)Nc3ccsc3Cl)c2n1
Show InChI InChI=1S/C17H18ClN5OS2.C2HF3O2/c18-15-12(5-6-25-15)22-16(24)9-8-26-17-14(9)23-13(7-20-17)21-11-4-2-1-3-10(11)19;3-2(4,5)1(6)7/h5-8,10-11H,1-4,19H2,(H,21,23)(H,22,24);(H,6,7)/t10-,11+;/m0./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278871
PNG
(2-{[(1R,2S)-2- aminocyclohexyl]amino}- N-(4-(diflu...)
Show SMILES OC(=O)C(F)(F)F.N[C@H]1CCCC[C@H]1Nc1cnc2scc(C(=O)Nc3cscc3C(F)F)c2n1
Show InChI InChI=1S/C18H19F2N5OS2.C2HF3O2/c19-16(20)9-6-27-8-13(9)24-17(26)10-7-28-18-15(10)25-14(5-22-18)23-12-4-2-1-3-11(12)21;3-2(4,5)1(6)7/h5-8,11-12,16H,1-4,21H2,(H,23,25)(H,24,26);(H,6,7)/t11-,12+;/m0./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278930
PNG
(2-{[(1R,2S)-2- aminocyclohexyl]- amino}-N-(4- chlo...)
Show SMILES OC(=O)C(F)(F)F.N[C@H]1CCCC[C@H]1Nc1cnc2scc(C(=O)Nc3cscc3Cl)c2n1
Show InChI InChI=1S/C17H18ClN5OS2.C2HF3O2/c18-10-7-25-8-13(10)22-16(24)9-6-26-17-15(9)23-14(5-20-17)21-12-4-2-1-3-11(12)19;3-2(4,5)1(6)7/h5-8,11-12H,1-4,19H2,(H,21,23)(H,22,24);(H,6,7)/t11-,12+;/m0./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278825
PNG
(N-[1-methyl-3- (trifluoromethyl)-1H- pyrazol-4-yl]...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2csc3ncc(N[C@@H]4CCCNC4)nc23)c(n1)C(F)(F)F
Show InChI InChI=1S/C17H18F3N7OS.C2HF3O2/c1-27-7-11(14(26-27)17(18,19)20)24-15(28)10-8-29-16-13(10)25-12(6-22-16)23-9-3-2-4-21-5-9;3-2(4,5)1(6)7/h6-9,21H,2-5H2,1H3,(H,23,25)(H,24,28);(H,6,7)/t9-;/m1./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278912
PNG
(2-{(1R,2S)-2- aminocyclohexyl]- amino}-N-(2- chlor...)
Show SMILES OC(=O)C(F)(F)F.N[C@H]1CCCC[C@H]1Nc1cnc2scc(C(=O)Nc3ccccc3Cl)c2n1
Show InChI InChI=1S/C19H20ClN5OS.C2HF3O2/c20-12-5-1-3-7-14(12)24-18(26)11-10-27-19-17(11)25-16(9-22-19)23-15-8-4-2-6-13(15)21;3-2(4,5)1(6)7/h1,3,5,7,9-10,13,15H,2,4,6,8,21H2,(H,23,25)(H,24,26);(H,6,7)/t13-,15+;/m0./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278875
PNG
(2-{[(1R,2S)-2-amino- cyclohexyl]amino}- N-(2-bromo...)
Show SMILES OC(=O)C(F)(F)F.N[C@H]1CCCC[C@H]1Nc1cnc2scc(C(=O)Nc3ccsc3Br)c2n1
Show InChI InChI=1S/C17H18BrN5OS2.C2HF3O2/c18-15-12(5-6-25-15)22-16(24)9-8-26-17-14(9)23-13(7-20-17)21-11-4-2-1-3-10(11)19;3-2(4,5)1(6)7/h5-8,10-11H,1-4,19H2,(H,21,23)(H,22,24);(H,6,7)/t10-,11+;/m0./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278844
PNG
(2-[(1S,4S)- or (1R,4R)- 2,5-diazabicyclo[2.2.2] oc...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2csc3ncc(nc23)N2C[C@H]3CC[C@@H]2CN3)c(n1)C(F)F
Show InChI InChI=1S/C18H19F2N7OS.C2HF3O2/c1-26-7-12(15(25-26)16(19)20)23-17(28)11-8-29-18-14(11)24-13(5-22-18)27-6-9-2-3-10(27)4-21-9;3-2(4,5)1(6)7/h5,7-10,16,21H,2-4,6H2,1H3,(H,23,28);(H,6,7)/t9-,10-;/m1./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278830
PNG
(2-[(3R)-3- aminopiperidin-1-yl]- N-[1-methyl-3- (t...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2csc3ncc(nc23)N2CCC[C@@H](N)C2)c(n1)C(F)(F)F
Show InChI InChI=1S/C17H18F3N7OS.C2HF3O2/c1-26-7-11(14(25-26)17(18,19)20)23-15(28)10-8-29-16-13(10)24-12(5-22-16)27-4-2-3-9(21)6-27;3-2(4,5)1(6)7/h5,7-9H,2-4,6,21H2,1H3,(H,23,28);(H,6,7)/t9-;/m1./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278905
PNG
(N-(2- cyanophenyl)-2- [(3R)-piperidin- 3-ylamino]-...)
Show SMILES OC(=O)C(F)(F)F.O=C(Nc1ccccc1C#N)c1csc2ncc(N[C@@H]3CCCNC3)nc12
Show InChI InChI=1S/C19H18N6OS.C2HF3O2/c20-8-12-4-1-2-6-15(12)24-18(26)14-11-27-19-17(14)25-16(10-22-19)23-13-5-3-7-21-9-13;3-2(4,5)1(6)7/h1-2,4,6,10-11,13,21H,3,5,7,9H2,(H,23,25)(H,24,26);(H,6,7)/t13-;/m1./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278866
PNG
(2-(3,8- diazabicyclo[3.2.1]oct- 8-yl)-N-[1-methyl-...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2csc3ncc(nc23)N2C3CCC2CNC3)c(n1)C(F)(F)F
Show InChI InChI=1S/C18H18F3N7OS.C2HF3O2/c1-27-7-12(15(26-27)18(19,20)21)24-16(29)11-8-30-17-14(11)25-13(6-23-17)28-9-2-3-10(28)5-22-4-9;3-2(4,5)1(6)7/h6-10,22H,2-5H2,1H3,(H,24,29);(H,6,7)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278855
PNG
(2-[(3S)- or (3R)- azepan-3-ylamino]-N- [3-(difluor...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2csc3ncc(N[C@H]4CCCCNC4)nc23)c(n1)C(F)F
Show InChI InChI=1S/C18H21F2N7OS.C2HF3O2/c1-27-8-12(15(26-27)16(19)20)24-17(28)11-9-29-18-14(11)25-13(7-22-18)23-10-4-2-3-5-21-6-10;3-2(4,5)1(6)7/h7-10,16,21H,2-6H2,1H3,(H,23,25)(H,24,28);(H,6,7)/t10-;/m0./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278907
PNG
(2-{[(1R,2S)-2- aminocyclohexyl]- amino}-N-(2- brom...)
Show SMILES OC(=O)C(F)(F)F.N[C@H]1CCCC[C@H]1Nc1cnc2scc(C(=O)Nc3ccccc3Br)c2n1
Show InChI InChI=1S/C19H20BrN5OS.C2HF3O2/c20-12-5-1-3-7-14(12)24-18(26)11-10-27-19-17(11)25-16(9-22-19)23-15-8-4-2-6-13(15)21;3-2(4,5)1(6)7/h1,3,5,7,9-10,13,15H,2,4,6,8,21H2,(H,23,25)(H,24,26);(H,6,7)/t13-,15+;/m0./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278833
PNG
(N-[3-(difluoromethyl)- 1-methyl-1H-pyrazol- 4-yl]-...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2csc3ncc(nc23)N2CCNCC2)c(n1)C(F)F
Show InChI InChI=1S/C16H17F2N7OS.C2HF3O2/c1-24-7-10(13(23-24)14(17)18)21-15(26)9-8-27-16-12(9)22-11(6-20-16)25-4-2-19-3-5-25;3-2(4,5)1(6)7/h6-8,14,19H,2-5H2,1H3,(H,21,26);(H,6,7)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278913
PNG
(2-[(3S)- or (3R)- azepan-3- ylamino]-N-(2- cyanoph...)
Show SMILES OC(=O)C(F)(F)F.O=C(Nc1ccccc1C#N)c1csc2ncc(N[C@H]3CCCCNC3)nc12
Show InChI InChI=1S/C20H20N6OS.C2HF3O2/c21-9-13-5-1-2-7-16(13)25-19(27)15-12-28-20-18(15)26-17(11-23-20)24-14-6-3-4-8-22-10-14;3-2(4,5)1(6)7/h1-2,5,7,11-12,14,22H,3-4,6,8,10H2,(H,24,26)(H,25,27);(H,6,7)/t14-;/m0./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278832
PNG
(2-(2,5- diazabicyclo[2.2.2] oct-2-yl)-N-[3- (diflu...)
Show SMILES Cn1cc(NC(=O)c2csc3ncc(nc23)N2CC3CCC2CN3)c(n1)C(F)F
Show InChI InChI=1S/C18H19F2N7OS/c1-26-7-12(15(25-26)16(19)20)23-17(28)11-8-29-18-14(11)24-13(5-22-18)27-6-9-2-3-10(27)4-21-9/h5,7-10,16,21H,2-4,6H2,1H3,(H,23,28)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278836
PNG
(2-(azepan-3-ylamino)- N-[1-methyl-3 (trifluorometh...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2csc3ncc(NC4CCCCNC4)nc23)c(n1)C(F)(F)F
Show InChI InChI=1S/C18H20F3N7OS.C2HF3O2/c1-28-8-12(15(27-28)18(19,20)21)25-16(29)11-9-30-17-14(11)26-13(7-23-17)24-10-4-2-3-5-22-6-10;3-2(4,5)1(6)7/h7-10,22H,2-6H2,1H3,(H,24,26)(H,25,29);(H,6,7)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278835
PNG
(2-(1,4-diazepan-1-yl)- N-[3-(difluoromethyl)- 1-me...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2csc3ncc(nc23)N2CCCNCC2)c(n1)C(F)F
Show InChI InChI=1S/C17H19F2N7OS.C2HF3O2/c1-25-8-11(14(24-25)15(18)19)22-16(27)10-9-28-17-13(10)23-12(7-21-17)26-5-2-3-20-4-6-26;3-2(4,5)1(6)7/h7-9,15,20H,2-6H2,1H3,(H,22,27);(H,6,7)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278834
PNG
(2-(5,8- diazaspiro[2.6]non-5- yl)-N-[3- (difluorom...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2csc3ncc(nc23)N2CCNCC3(CC3)C2)c(n1)C(F)F
Show InChI InChI=1S/C19H21F2N7OS.C2HF3O2/c1-27-7-12(15(26-27)16(20)21)24-17(29)11-8-30-18-14(11)25-13(6-23-18)28-5-4-22-9-19(10-28)2-3-19;3-2(4,5)1(6)7/h6-8,16,22H,2-5,9-10H2,1H3,(H,24,29);(H,6,7)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278852
PNG
(2-[(3S)- or (3R)- azepan-3-ylamino]-N- [1-methyl-3...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2csc3ncc(N[C@H]4CCCCNC4)nc23)c(n1)C(F)(F)F
Show InChI InChI=1S/C18H20F3N7OS.C2HF3O2/c1-28-8-12(15(27-28)18(19,20)21)25-16(29)11-9-30-17-14(11)26-13(7-23-17)24-10-4-2-3-5-22-6-10;3-2(4,5)1(6)7/h7-10,22H,2-6H2,1H3,(H,24,26)(H,25,29);(H,6,7)/t10-;/m0./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278843
PNG
(2-[(1S,4S)- or (1R,4R)- 2,5-diazabicyclo[2.2.2] oc...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2csc3ncc(nc23)N2C[C@@H]3CC[C@H]2CN3)c(n1)C(F)F
Show InChI InChI=1S/C18H19F2N7OS.C2HF3O2/c1-26-7-12(15(25-26)16(19)20)23-17(28)11-8-29-18-14(11)24-13(5-22-18)27-6-9-2-3-10(27)4-21-9;3-2(4,5)1(6)7/h5,7-10,16,21H,2-4,6H2,1H3,(H,23,28);(H,6,7)/t9-,10-;/m0./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278914
PNG
(2-[(3S)- or (3R)- azepan-3- ylamino]-N-(2- cyanoph...)
Show SMILES OC(=O)C(F)(F)F.O=C(Nc1ccccc1C#N)c1csc2ncc(N[C@@H]3CCCCNC3)nc12
Show InChI InChI=1S/C20H20N6OS.C2HF3O2/c21-9-13-5-1-2-7-16(13)25-19(27)15-12-28-20-18(15)26-17(11-23-20)24-14-6-3-4-8-22-10-14;3-2(4,5)1(6)7/h1-2,5,7,11-12,14,22H,3-4,6,8,10H2,(H,24,26)(H,25,27);(H,6,7)/t14-;/m1./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278897
PNG
(2-{[(1R,2S)-2-amino- cyclohexyl]amino}- N-(2-(trif...)
Show SMILES OC(=O)C(F)(F)F.N[C@H]1CCCC[C@H]1Nc1cnc2scc(C(=O)Nc3ccsc3C(F)(F)F)c2n1
Show InChI InChI=1S/C18H18F3N5OS2.C2HF3O2/c19-18(20,21)15-12(5-6-28-15)25-16(27)9-8-29-17-14(9)26-13(7-23-17)24-11-4-2-1-3-10(11)22;3-2(4,5)1(6)7/h5-8,10-11H,1-4,22H2,(H,24,26)(H,25,27);(H,6,7)/t10-,11+;/m0./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278839
PNG
(N-(3-chloro-1-methyl- 1H-pyrazol-4-yl)-2- (1,4-dia...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2csc3ncc(nc23)N2CCCNCC2)c(Cl)n1
Show InChI InChI=1S/C16H18ClN7OS.C2HF3O2/c1-23-8-11(14(17)22-23)20-15(25)10-9-26-16-13(10)21-12(7-19-16)24-5-2-3-18-4-6-24;3-2(4,5)1(6)7/h7-9,18H,2-6H2,1H3,(H,20,25);(H,6,7)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278842
PNG
(N-(3-bromo-1-methyl- 1H-pyrazol-4-yl)-2- (1,4-diaz...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2csc3ncc(nc23)N2CCCNCC2)c(Br)n1
Show InChI InChI=1S/C16H18BrN7OS.C2HF3O2/c1-23-8-11(14(17)22-23)20-15(25)10-9-26-16-13(10)21-12(7-19-16)24-5-2-3-18-4-6-24;3-2(4,5)1(6)7/h7-9,18H,2-6H2,1H3,(H,20,25);(H,6,7)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278838
PNG
(N-(3-chloro-1-methyl- 1H-pyrazol-4-yl)-2- [(1S,4S)...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2csc3ncc(nc23)N2C[C@H]3CC[C@@H]2CN3)c(Cl)n1
Show InChI InChI=1S/C17H18ClN7OS.C2HF3O2/c1-24-7-12(15(18)23-24)21-16(26)11-8-27-17-14(11)22-13(5-20-17)25-6-9-2-3-10(25)4-19-9;3-2(4,5)1(6)7/h5,7-10,19H,2-4,6H2,1H3,(H,21,26);(H,6,7)/t9-,10-;/m1./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278863
PNG
(2-{[(1R,2S)-2- aminocyclohexyl]amino}- N-(1-methyl...)
Show SMILES OC(=O)C(F)(F)F.C[N]1=C(C(NC(=O)c2csc3ncc(N[C@@H]4CCCC[C@@H]4N)nc23)=CN1)C(F)(F)F
Show InChI InChI=1S/C18H21F3N7OS.C2HF3O2/c1-28-15(18(19,20)21)12(6-24-28)26-16(29)9-8-30-17-14(9)27-13(7-23-17)25-11-5-3-2-4-10(11)22;3-2(4,5)1(6)7/h6-8,10-11,24H,2-5,22H2,1H3,(H,25,27)(H,26,29);(H,6,7)/t10-,11+;/m0./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278827
PNG
(2-(1,4-diazepan-1-yl)- N-[1-methyl-3- (trifluorome...)
Show SMILES Cn1cc(NC(=O)c2csc3ncc(nc23)N2CCCNCC2)c(n1)C(F)(F)F
Show InChI InChI=1S/C17H18F3N7OS/c1-26-8-11(14(25-26)17(18,19)20)23-15(28)10-9-29-16-13(10)24-12(7-22-16)27-5-2-3-21-4-6-27/h7-9,21H,2-6H2,1H3,(H,23,28)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278862
PNG
(2-(3,8- diazabicyclo[3.2.1]oct- 3-yl)-N-[1-methyl-...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2csc3ncc(nc23)N2CC3CCC(C2)N3)c(n1)C(F)(F)F
Show InChI InChI=1S/C18H18F3N7OS.C2HF3O2/c1-27-7-12(15(26-27)18(19,20)21)24-16(29)11-8-30-17-14(11)25-13(4-22-17)28-5-9-2-3-10(6-28)23-9;3-2(4,5)1(6)7/h4,7-10,23H,2-3,5-6H2,1H3,(H,24,29);(H,6,7)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278829
PNG
(2-(5,8- diazaspiro[2.6]non-5- yl)-N-[1-methyl-3- (...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2csc3ncc(nc23)N2CCNCC3(CC3)C2)c(n1)C(F)(F)F
Show InChI InChI=1S/C19H20F3N7OS.C2HF3O2/c1-28-7-12(15(27-28)19(20,21)22)25-16(30)11-8-31-17-14(11)26-13(6-24-17)29-5-4-23-9-18(10-29)2-3-18;3-2(4,5)1(6)7/h6-8,23H,2-5,9-10H2,1H3,(H,25,30);(H,6,7)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278841
PNG
(N-(3-bromo-1-methyl- 1H-pyrazol-4-yl)-2- [(1S,4S)-...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2csc3ncc(nc23)N2C[C@H]3CC[C@@H]2CN3)c(Br)n1
Show InChI InChI=1S/C17H18BrN7OS.C2HF3O2/c1-24-7-12(15(18)23-24)21-16(26)11-8-27-17-14(11)22-13(5-20-17)25-6-9-2-3-10(25)4-19-9;3-2(4,5)1(6)7/h5,7-10,19H,2-4,6H2,1H3,(H,21,26);(H,6,7)/t9-,10-;/m1./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278880
PNG
(2-[(1S,4S)- or (1R,4R)- 2,5-diazabicyclo [2.2.2]oc...)
Show SMILES OC(=O)C(F)(F)F.FC(F)c1cscc1NC(=O)c1csc2ncc(nc12)N1C[C@H]2CC[C@@H]1CN2
Show InChI InChI=1S/C18H17F2N5OS2.C2HF3O2/c19-16(20)11-6-27-8-13(11)23-17(26)12-7-28-18-15(12)24-14(4-22-18)25-5-9-1-2-10(25)3-21-9;3-2(4,5)1(6)7/h4,6-10,16,21H,1-3,5H2,(H,23,26);(H,6,7)/t9-,10-;/m1./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278922
PNG
(2-{[(1R,2S)-2- aminocyclohexyl]- amino}-N-[2- (dif...)
Show SMILES OC(=O)C(F)(F)F.N[C@H]1CCCC[C@H]1Nc1cnc2scc(C(=O)Nc3ccccc3C(F)F)c2n1
Show InChI InChI=1S/C20H21F2N5OS.C2HF3O2/c21-18(22)11-5-1-3-7-14(11)26-19(28)12-10-29-20-17(12)27-16(9-24-20)25-15-8-4-2-6-13(15)23;3-2(4,5)1(6)7/h1,3,5,7,9-10,13,15,18H,2,4,6,8,23H2,(H,25,27)(H,26,28);(H,6,7)/t13-,15+;/m0./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278849
PNG
(N-(3-cyano-1-methyl- 1H-pyrazol-4-yl)-2- (1,4-diaz...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2csc3ncc(nc23)N2CCCNCC2)c(n1)C#N
Show InChI InChI=1S/C17H18N8OS.C2HF3O2/c1-24-9-13(12(7-18)23-24)21-16(26)11-10-27-17-15(11)22-14(8-20-17)25-5-2-3-19-4-6-25;3-2(4,5)1(6)7/h8-10,19H,2-6H2,1H3,(H,21,26);(H,6,7)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278831
PNG
(N-[3-(difluoromethyl)- 1-methyl-1H-pyrazol- 4-yl]-...)
Show SMILES Cn1cc(NC(=O)c2csc3ncc(N[C@@H]4CCCC[C@@H]4O)nc23)c(n1)C(F)F
Show InChI InChI=1S/C18H20F2N6O2S/c1-26-7-11(15(25-26)16(19)20)23-17(28)9-8-29-18-14(9)24-13(6-21-18)22-10-4-2-3-5-12(10)27/h6-8,10,12,16,27H,2-5H2,1H3,(H,22,24)(H,23,28)/t10-,12+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278860
PNG
(2-{[(1R,2R)-2-amino- 3,3-difluorocyclohexyl] amino...)
Show SMILES Cn1cc(NC(=O)c2csc3ncc(N[C@@H]4CCCC(F)(F)[C@@H]4N)nc23)c(n1)C(F)F
Show InChI InChI=1S/C18H19F4N7OS/c1-29-6-10(13(28-29)15(19)20)26-16(30)8-7-31-17-12(8)27-11(5-24-17)25-9-3-2-4-18(21,22)14(9)23/h5-7,9,14-15H,2-4,23H2,1H3,(H,25,27)(H,26,30)/t9-,14-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278904
PNG
(2-[(3R)-3- aminopiperidin- 1-yl]-N-(2- cyanophenyl...)
Show SMILES OC(=O)C(F)(F)F.N[C@@H]1CCCN(C1)c1cnc2scc(C(=O)Nc3ccccc3C#N)c2n1
Show InChI InChI=1S/C19H18N6OS.C2HF3O2/c20-8-12-4-1-2-6-15(12)23-18(26)14-11-27-19-17(14)24-16(9-22-19)25-7-3-5-13(21)10-25;3-2(4,5)1(6)7/h1-2,4,6,9,11,13H,3,5,7,10,21H2,(H,23,26);(H,6,7)/t13-;/m1./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278848
PNG
(N-(3-cyano-1-methyl- 1H-pyrazol-4-yl)-2- [(1S,4S)-...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2csc3ncc(nc23)N2C[C@H]3CC[C@@H]2CN3)c(n1)C#N
Show InChI InChI=1S/C18H18N8OS.C2HF3O2/c1-25-8-14(13(4-19)24-25)22-17(27)12-9-28-18-16(12)23-15(6-21-18)26-7-10-2-3-11(26)5-20-10;3-2(4,5)1(6)7/h6,8-11,20H,2-3,5,7H2,1H3,(H,22,27);(H,6,7)/t10-,11-;/m1./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278868
PNG
(2-(1,4-diazepan-1-yl)- N-[4-(difluoromethyl) thiop...)
Show SMILES OC(=O)C(F)(F)F.FC(F)c1cscc1NC(=O)c1csc2ncc(nc12)N1CCCNCC1
Show InChI InChI=1S/C17H17F2N5OS2.C2HF3O2/c18-15(19)10-7-26-9-12(10)22-16(25)11-8-27-17-14(11)23-13(6-21-17)24-4-1-2-20-3-5-24;3-2(4,5)1(6)7/h6-9,15,20H,1-5H2,(H,22,25);(H,6,7)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278823
PNG
(N-[1-methyl-3- (trifluoromethyl)-1H- pyrazol-4-yl]...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2csc3ncc(nc23)N2CCNCC2)c(n1)C(F)(F)F
Show InChI InChI=1S/C16H16F3N7OS.C2HF3O2/c1-25-7-10(13(24-25)16(17,18)19)22-14(27)9-8-28-15-12(9)23-11(6-21-15)26-4-2-20-3-5-26;3-2(4,5)1(6)7/h6-8,20H,2-5H2,1H3,(H,22,27);(H,6,7)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278847
PNG
(N-(3-cyano-1-methyl- 1H-pyrazol-4-yl)-2- [(1S,4S)-...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2csc3ncc(nc23)N2C[C@@H]3CC[C@H]2CN3)c(n1)C#N
Show InChI InChI=1S/C18H18N8OS.C2HF3O2/c1-25-8-14(13(4-19)24-25)22-17(27)12-9-28-18-16(12)23-15(6-21-18)26-7-10-2-3-11(26)5-20-10;3-2(4,5)1(6)7/h6,8-11,20H,2-3,5,7H2,1H3,(H,22,27);(H,6,7)/t10-,11-;/m0./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278857
PNG
(2-{[(1R,2R)-2-amino- 3,3-difluorocyclohexyl] amino...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2csc3ncc(N[C@@H]4CCCC(F)(F)[C@@H]4N)nc23)c(n1)C#N
Show InChI InChI=1S/C18H18F2N8OS.C2HF3O2/c1-28-7-12(11(5-21)27-28)25-16(29)9-8-30-17-14(9)26-13(6-23-17)24-10-3-2-4-18(19,20)15(10)22;3-2(4,5)1(6)7/h6-8,10,15H,2-4,22H2,1H3,(H,24,26)(H,25,29);(H,6,7)/t10-,15-;/m1./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278864
PNG
(2-{[(1R,2R)-2-amino- 3,3-difluorocyclohexyl] amino...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2csc3ncc(N[C@@H]4CCCC(F)(F)[C@@H]4N)nc23)c(Cl)n1
Show InChI InChI=1S/C17H18ClF2N7OS.C2HF3O2/c1-27-6-10(14(18)26-27)24-15(28)8-7-29-16-12(8)25-11(5-22-16)23-9-3-2-4-17(19,20)13(9)21;3-2(4,5)1(6)7/h5-7,9,13H,2-4,21H2,1H3,(H,23,25)(H,24,28);(H,6,7)/t9-,13-;/m1./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278840
PNG
(N-(3-bromo-1-methyl- 1H-pyrazol-4-yl)-2- [(1S,4S)-...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2csc3ncc(nc23)N2C[C@@H]3CC[C@H]2CN3)c(Br)n1
Show InChI InChI=1S/C17H18BrN7OS.C2HF3O2/c1-24-7-12(15(18)23-24)21-16(26)11-8-27-17-14(11)22-13(5-20-17)25-6-9-2-3-10(25)4-19-9;3-2(4,5)1(6)7/h5,7-10,19H,2-4,6H2,1H3,(H,21,26);(H,6,7)/t9-,10-;/m0./s1
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n/an/a 70n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278837
PNG
(N-(3-chloro-1-methyl- 1H-pyrazol-4-yl)-2- [(1S,4S)...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2csc3ncc(nc23)N2C[C@@H]3CC[C@H]2CN3)c(Cl)n1
Show InChI InChI=1S/C17H18ClN7OS.C2HF3O2/c1-24-7-12(15(18)23-24)21-16(26)11-8-27-17-14(11)22-13(5-20-17)25-6-9-2-3-10(25)4-19-9;3-2(4,5)1(6)7/h5,7-10,19H,2-4,6H2,1H3,(H,21,26);(H,6,7)/t9-,10-;/m0./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278901
PNG
(2-{[(1R,2S)-2- aminocyclo- hexyl]amino}- N-[2- (tr...)
Show SMILES OC(=O)C(F)(F)F.N[C@H]1CCCC[C@H]1Nc1cnc2scc(C(=O)Nc3ccccc3C(F)(F)F)c2n1
Show InChI InChI=1S/C20H20F3N5OS.C2HF3O2/c21-20(22,23)12-5-1-3-7-14(12)27-18(29)11-10-30-19-17(11)28-16(9-25-19)26-15-8-4-2-6-13(15)24;3-2(4,5)1(6)7/h1,3,5,7,9-10,13,15H,2,4,6,8,24H2,(H,26,28)(H,27,29);(H,6,7)/t13-,15+;/m0./s1
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n/an/a 86n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278824
PNG
(2-{[(1R,2S)-2- hydroxycyclohexyl] amino}-N-[1-meth...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2csc3ncc(N[C@@H]4CCCC[C@@H]4O)nc23)c(n1)C(F)(F)F
Show InChI InChI=1S/C18H19F3N6O2S.C2HF3O2/c1-27-7-11(15(26-27)18(19,20)21)24-16(29)9-8-30-17-14(9)25-13(6-22-17)23-10-4-2-3-5-12(10)28;3-2(4,5)1(6)7/h6-8,10,12,28H,2-5H2,1H3,(H,23,25)(H,24,29);(H,6,7)/t10-,12+;/m1./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278929
PNG
(N-(4- chlorothiophen- 3-yl)-2-[(1S,4S)- or (1R,4R)...)
Show SMILES OC(=O)C(F)(F)F.Clc1cscc1NC(=O)c1csc2ncc(nc12)N1C[C@H]2CC[C@@H]1CN2
Show InChI InChI=1S/C17H16ClN5OS2.C2HF3O2/c18-12-7-25-8-13(12)21-16(24)11-6-26-17-15(11)22-14(4-20-17)23-5-9-1-2-10(23)3-19-9;3-2(4,5)1(6)7/h4,6-10,19H,1-3,5H2,(H,21,24);(H,6,7)/t9-,10-;/m1./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278850
PNG
(2-{[(1R,2R)-2-amino- 3,3-difluorocyclohexyl] amino...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2csc3ncc(N[C@@H]4CCCC(F)(F)[C@@H]4N)nc23)c(Br)n1
Show InChI InChI=1S/C17H18BrF2N7OS.C2HF3O2/c1-27-6-10(14(18)26-27)24-15(28)8-7-29-16-12(8)25-11(5-22-16)23-9-3-2-4-17(19,20)13(9)21;3-2(4,5)1(6)7/h5-7,9,13H,2-4,21H2,1H3,(H,23,25)(H,24,28);(H,6,7)/t9-,13-;/m1./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278828
PNG
(2-(2,5- diazabicyclo[2.2.2]oct- 2-yl)-N-[1-methyl-...)
Show SMILES Cn1cc(NC(=O)c2csc3ncc(nc23)N2CC3CCC2CN3)c(n1)C(F)(F)F
Show InChI InChI=1S/C18H18F3N7OS/c1-27-7-12(15(26-27)18(19,20)21)24-16(29)11-8-30-17-14(11)25-13(5-23-17)28-6-9-2-3-10(28)4-22-9/h5,7-10,22H,2-4,6H2,1H3,(H,24,29)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278925
PNG
(2-{[(1R,2R)-2- amino-3,3- difluorocyclohexyl]- ami...)
Show SMILES OC(=O)C(F)(F)F.N[C@@H]1[C@@H](CCCC1(F)F)Nc1cnc2scc(C(=O)Nc3ccccc3C#N)c2n1
Show InChI InChI=1S/C20H18F2N6OS.C2HF3O2/c21-20(22)7-3-6-14(17(20)24)26-15-9-25-19-16(28-15)12(10-30-19)18(29)27-13-5-2-1-4-11(13)8-23;3-2(4,5)1(6)7/h1-2,4-5,9-10,14,17H,3,6-7,24H2,(H,26,28)(H,27,29);(H,6,7)/t14-,17-;/m1./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278927
PNG
(N-(4- chlorothiophen- 3-yl)-2-(1,4- diazepan-1-yl)...)
Show SMILES OC(=O)C(F)(F)F.Clc1cscc1NC(=O)c1csc2ncc(nc12)N1CCCNCC1
Show InChI InChI=1S/C16H16ClN5OS2.C2HF3O2/c17-11-8-24-9-12(11)20-15(23)10-7-25-16-14(10)21-13(6-19-16)22-4-1-2-18-3-5-22;3-2(4,5)1(6)7/h6-9,18H,1-5H2,(H,20,23);(H,6,7)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278917
PNG
(N-(2- cyanophenyl)-2- [(1S,4S)- or (1R,4R)-2,5- di...)
Show SMILES OC(=O)C(F)(F)F.O=C(Nc1ccccc1C#N)c1csc2ncc(nc12)N1C[C@@H]2CC[C@H]1CN2
Show InChI InChI=1S/C20H18N6OS.C2HF3O2/c21-7-12-3-1-2-4-16(12)24-19(27)15-11-28-20-18(15)25-17(9-23-20)26-10-13-5-6-14(26)8-22-13;3-2(4,5)1(6)7/h1-4,9,11,13-14,22H,5-6,8,10H2,(H,24,27);(H,6,7)/t13-,14-;/m0./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278876
PNG
(N-(4-cyanothiophen-3- yl)-2-(1,4-diazepan-1- yl)th...)
Show SMILES OC(=O)C(F)(F)F.O=C(Nc1cscc1C#N)c1csc2ncc(nc12)N1CCCNCC1
Show InChI InChI=1S/C17H16N6OS2.C2HF3O2/c18-6-11-8-25-10-13(11)21-16(24)12-9-26-17-15(12)22-14(7-20-17)23-4-1-2-19-3-5-23;3-2(4,5)1(6)7/h7-10,19H,1-5H2,(H,21,24);(H,6,7)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278920
PNG
(N-(2- chlorophenyl)-2- [(1S,4S)- or (1R,4R)-2,5- d...)
Show SMILES OC(=O)C(F)(F)F.Clc1ccccc1NC(=O)c1csc2ncc(nc12)N1C[C@H]2CC[C@@H]1CN2
Show InChI InChI=1S/C19H18ClN5OS.C2HF3O2/c20-14-3-1-2-4-15(14)23-18(26)13-10-27-19-17(13)24-16(8-22-19)25-9-11-5-6-12(25)7-21-11;3-2(4,5)1(6)7/h1-4,8,10-12,21H,5-7,9H2,(H,23,26);(H,6,7)/t11-,12-;/m1./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278870
PNG
(N-(4-bromothiophen-3- yl)-2-[(1S,4S)- or (1R,4R)-2...)
Show SMILES OC(=O)C(F)(F)F.Brc1cscc1NC(=O)c1csc2ncc(nc12)N1C[C@H]2CC[C@@H]1CN2
Show InChI InChI=1S/C17H16BrN5OS2.C2HF3O2/c18-12-7-25-8-13(12)21-16(24)11-6-26-17-15(11)22-14(4-20-17)23-5-9-1-2-10(23)3-19-9;3-2(4,5)1(6)7/h4,6-10,19H,1-3,5H2,(H,21,24);(H,6,7)/t9-,10-;/m1./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278887
PNG
(N-(4-cyanothiophen-3- yl)-2-[(1S,4S)- or (1R,4R)-2...)
Show SMILES OC=O.O=C(Nc1cscc1C#N)c1csc2ncc(nc12)N1C[C@H]2CC[C@@H]1CN2
Show InChI InChI=1S/C18H16N6OS2.CH2O2/c19-3-10-7-26-9-14(10)22-17(25)13-8-27-18-16(13)23-15(5-21-18)24-6-11-1-2-12(24)4-20-11;2-1-3/h5,7-9,11-12,20H,1-2,4,6H2,(H,22,25);1H,(H,2,3)/t11-,12-;/m1./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278891
PNG
(N-(2-cyanothiophen-3- yl)-2-[(1S,4S)- or (1R,4R)-2...)
Show SMILES OC(=O)C(F)(F)F.O=C(Nc1ccsc1C#N)c1csc2ncc(nc12)N1C[C@H]2CC[C@@H]1CN2
Show InChI InChI=1S/C18H16N6OS2.C2HF3O2/c19-5-14-13(3-4-26-14)22-17(25)12-9-27-18-16(12)23-15(7-21-18)24-8-10-1-2-11(24)6-20-10;3-2(4,5)1(6)7/h3-4,7,9-11,20H,1-2,6,8H2,(H,22,25);(H,6,7)/t10-,11-;/m1./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278890
PNG
(N-(2-cyanothiophen-3- yl)-2-[(1S,4S)- or (1R,4R)-2...)
Show SMILES OC(=O)C(F)(F)F.O=C(Nc1ccsc1C#N)c1csc2ncc(nc12)N1C[C@@H]2CC[C@H]1CN2
Show InChI InChI=1S/C18H16N6OS2.C2HF3O2/c19-5-14-13(3-4-26-14)22-17(25)12-9-27-18-16(12)23-15(7-21-18)24-8-10-1-2-11(24)6-20-10;3-2(4,5)1(6)7/h3-4,7,9-11,20H,1-2,6,8H2,(H,22,25);(H,6,7)/t10-,11-;/m0./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278918
PNG
(N-(2- cyanophenyl)-2- [(1S,4S)- or (1R,4R)-2,5- di...)
Show SMILES OC(=O)C(F)(F)F.O=C(Nc1ccccc1C#N)c1csc2ncc(nc12)N1C[C@H]2CC[C@@H]1CN2
Show InChI InChI=1S/C20H18N6OS.C2HF3O2/c21-7-12-3-1-2-4-16(12)24-19(27)15-11-28-20-18(15)25-17(9-23-20)26-10-13-5-6-14(26)8-22-13;3-2(4,5)1(6)7/h1-4,9,11,13-14,22H,5-6,8,10H2,(H,24,27);(H,6,7)/t13-,14-;/m1./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278883
PNG
(N-(2-chlorothiophen-3- yl)-2-[(1S,4S)- or (1R,4R)-...)
Show SMILES OC(=O)C(F)(F)F.Clc1sccc1NC(=O)c1csc2ncc(nc12)N1C[C@H]2CC[C@@H]1CN2
Show InChI InChI=1S/C17H16ClN5OS2.C2HF3O2/c18-15-12(3-4-25-15)21-16(24)11-8-26-17-14(11)22-13(6-20-17)23-7-9-1-2-10(23)5-19-9;3-2(4,5)1(6)7/h3-4,6,8-10,19H,1-2,5,7H2,(H,21,24);(H,6,7)/t9-,10-;/m1./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278879
PNG
(2-[(1S,4S)- or (1R,4R)- 2,5-diazabicyclo [2.2.2]oc...)
Show SMILES OC(=O)C(F)(F)F.FC(F)c1cscc1NC(=O)c1csc2ncc(nc12)N1C[C@@H]2CC[C@H]1CN2
Show InChI InChI=1S/C18H17F2N5OS2.C2HF3O2/c19-16(20)11-6-27-8-13(11)23-17(26)12-7-28-18-15(12)24-14(4-22-18)25-5-9-1-2-10(25)3-21-9;3-2(4,5)1(6)7/h4,6-10,16,21H,1-3,5H2,(H,23,26);(H,6,7)/t9-,10-;/m0./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278906
PNG
(N-(2- cyanophenyl)-2- piperazin-1-yl- thieno[2,3-b...)
Show SMILES OC(=O)C(F)(F)F.O=C(Nc1ccccc1C#N)c1csc2ncc(nc12)N1CCNCC1
Show InChI InChI=1S/C18H16N6OS.C2HF3O2/c19-9-12-3-1-2-4-14(12)22-17(25)13-11-26-18-16(13)23-15(10-21-18)24-7-5-20-6-8-24;3-2(4,5)1(6)7/h1-4,10-11,20H,5-8H2,(H,22,25);(H,6,7)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278928
PNG
(N-(4- chlorothiophen- 3-yl)-2-[(1S,4S)- or (1R,4R)...)
Show SMILES OC(=O)C(F)(F)F.Clc1cscc1NC(=O)c1csc2ncc(nc12)N1C[C@@H]2CC[C@H]1CN2
Show InChI InChI=1S/C17H16ClN5OS2.C2HF3O2/c18-12-7-25-8-13(12)21-16(24)11-6-26-17-15(11)22-14(4-20-17)23-5-9-1-2-10(23)3-19-9;3-2(4,5)1(6)7/h4,6-10,19H,1-3,5H2,(H,21,24);(H,6,7)/t9-,10-;/m0./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278886
PNG
(N-(4-cyanothiophen-3- yl)-2-[(1S,4S)- or (1R,4R)-2...)
Show SMILES OC=O.O=C(Nc1cscc1C#N)c1csc2ncc(nc12)N1C[C@@H]2CC[C@H]1CN2
Show InChI InChI=1S/C18H16N6OS2.CH2O2/c19-3-10-7-26-9-14(10)22-17(25)13-8-27-18-16(13)23-15(5-21-18)24-6-11-1-2-12(24)4-20-11;2-1-3/h5,7-9,11-12,20H,1-2,4,6H2,(H,22,25);1H,(H,2,3)/t11-,12-;/m0./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278884
PNG
(N-(2-bromothiophen-3- yl)-2-[(1S,4S)- or (1R,4R)-2...)
Show SMILES OC(=O)C(F)(F)F.Brc1sccc1NC(=O)c1csc2ncc(nc12)N1C[C@@H]2CC[C@H]1CN2
Show InChI InChI=1S/C17H16BrN5OS2.C2HF3O2/c18-15-12(3-4-25-15)21-16(24)11-8-26-17-14(11)22-13(6-20-17)23-7-9-1-2-10(23)5-19-9;3-2(4,5)1(6)7/h3-4,6,8-10,19H,1-2,5,7H2,(H,21,24);(H,6,7)/t9-,10-;/m0./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278888
PNG
(2-{[(1R,2R)-2-amino- 3,3-difluorocyclohexyl] amino...)
Show SMILES OC(=O)C(F)(F)F.N[C@@H]1[C@@H](CCCC1(F)F)Nc1cnc2scc(C(=O)Nc3cscc3C(F)F)c2n1
Show InChI InChI=1S/C18H17F4N5OS2.C2HF3O2/c19-15(20)8-5-29-7-11(8)26-16(28)9-6-30-17-13(9)27-12(4-24-17)25-10-2-1-3-18(21,22)14(10)23;3-2(4,5)1(6)7/h4-7,10,14-15H,1-3,23H2,(H,25,27)(H,26,28);(H,6,7)/t10-,14-;/m1./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278826
PNG
(2-{[(1R,2R)-2-amino- 3,3-difluorocyclohexyl] amino...)
Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2csc3ncc(N[C@@H]4CCCC(F)(F)[C@@H]4N)nc23)c(n1)C(F)(F)F
Show InChI InChI=1S/C18H18F5N7OS.C2HF3O2/c1-30-6-10(14(29-30)18(21,22)23)27-15(31)8-7-32-16-12(8)28-11(5-25-16)26-9-3-2-4-17(19,20)13(9)24;3-2(4,5)1(6)7/h5-7,9,13H,2-4,24H2,1H3,(H,26,28)(H,27,31);(H,6,7)/t9-,13-;/m1./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278869
PNG
(N-(4-bromothiophen-3- yl)-2-(1,4-diazepan-1- yl)th...)
Show SMILES OC(=O)C(F)(F)F.Brc1cscc1NC(=O)c1csc2ncc(nc12)N1CCCNCC1
Show InChI InChI=1S/C16H16BrN5OS2.C2HF3O2/c17-11-8-24-9-12(11)20-15(23)10-7-25-16-14(10)21-13(6-19-16)22-4-1-2-18-3-5-22;3-2(4,5)1(6)7/h6-9,18H,1-5H2,(H,20,23);(H,6,7)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278900
PNG
(2-{[(1R,2R)-2-amino- 3,3-difluorocyclohexyl] amino...)
Show SMILES OC(=O)C(F)(F)F.N[C@@H]1[C@@H](CCCC1(F)F)Nc1cnc2scc(C(=O)Nc3cscc3C#N)c2n1
Show InChI InChI=1S/C18H16F2N6OS2.C2HF3O2/c19-18(20)3-1-2-11(15(18)22)24-13-5-23-17-14(26-13)10(7-29-17)16(27)25-12-8-28-6-9(12)4-21;3-2(4,5)1(6)7/h5-8,11,15H,1-3,22H2,(H,24,26)(H,25,27);(H,6,7)/t11-,15-;/m1./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278893
PNG
(N-(2-cyanothiophen-3- yl)-2-(1,4-diazepan-1- yl)th...)
Show SMILES OC(=O)C(F)(F)F.O=C(Nc1ccsc1C#N)c1csc2ncc(nc12)N1CCCNCC1
Show InChI InChI=1S/C17H16N6OS2.C2HF3O2/c18-8-13-12(2-7-25-13)21-16(24)11-10-26-17-15(11)22-14(9-20-17)23-5-1-3-19-4-6-23;3-2(4,5)1(6)7/h2,7,9-10,19H,1,3-6H2,(H,21,24);(H,6,7)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278921
PNG
(2-{[(1R,2R)-2- amino-3,3- difluorocyclohexyl]- ami...)
Show SMILES OC(=O)C(F)(F)F.N[C@@H]1[C@@H](CCCC1(F)F)Nc1cnc2scc(C(=O)Nc3ccccc3Cl)c2n1
Show InChI InChI=1S/C19H18ClF2N5OS.C2HF3O2/c20-11-4-1-2-5-12(11)26-17(28)10-9-29-18-15(10)27-14(8-24-18)25-13-6-3-7-19(21,22)16(13)23;3-2(4,5)1(6)7/h1-2,4-5,8-9,13,16H,3,6-7,23H2,(H,25,27)(H,26,28);(H,6,7)/t13-,16-;/m1./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278873
PNG
(N-(2-chlorothiophen-3- yl)-2-(1,4-diazepan-1- yl)t...)
Show SMILES OC(=O)C(F)(F)F.Clc1sccc1NC(=O)c1csc2ncc(nc12)N1CCCNCC1
Show InChI InChI=1S/C16H16ClN5OS2.C2HF3O2/c17-14-11(2-7-24-14)20-15(23)10-9-25-16-13(10)21-12(8-19-16)22-5-1-3-18-4-6-22;3-2(4,5)1(6)7/h2,7-9,18H,1,3-6H2,(H,20,23);(H,6,7)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278911
PNG
(N-(2- chlorophenyl)-2- (1,4-diazepan-1- yl)thieno[...)
Show SMILES OC(=O)C(F)(F)F.Clc1ccccc1NC(=O)c1csc2ncc(nc12)N1CCCNCC1
Show InChI InChI=1S/C18H18ClN5OS.C2HF3O2/c19-13-4-1-2-5-14(13)22-17(25)12-11-26-18-16(12)23-15(10-21-18)24-8-3-6-20-7-9-24;3-2(4,5)1(6)7/h1-2,4-5,10-11,20H,3,6-9H2,(H,22,25);(H,6,7)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278909
PNG
(N-(2- bromophenyl)- 2-[(1S,4S)- or (1R,4R)-2,5- di...)
Show SMILES OC(=O)C(F)(F)F.Brc1ccccc1NC(=O)c1csc2ncc(nc12)N1C[C@H]2CC[C@@H]1CN2
Show InChI InChI=1S/C19H18BrN5OS.C2HF3O2/c20-14-3-1-2-4-15(14)23-18(26)13-10-27-19-17(13)24-16(8-22-19)25-9-11-5-6-12(25)7-21-11;3-2(4,5)1(6)7/h1-4,8,10-12,21H,5-7,9H2,(H,23,26);(H,6,7)/t11-,12-;/m1./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278931
PNG
(2-{[(1R,2R)-2- amino-3,3- difluorocyclohexyl]- ami...)
Show SMILES OC(=O)C(F)(F)F.N[C@@H]1[C@@H](CCCC1(F)F)Nc1cnc2scc(C(=O)Nc3cscc3Cl)c2n1
Show InChI InChI=1S/C17H16ClF2N5OS2.C2HF3O2/c18-9-6-27-7-11(9)24-15(26)8-5-28-16-13(8)25-12(4-22-16)23-10-2-1-3-17(19,20)14(10)21;3-2(4,5)1(6)7/h4-7,10,14H,1-3,21H2,(H,23,25)(H,24,26);(H,6,7)/t10-,14-;/m1./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278882
PNG
(N-(2-chlorothiophen-3- yl)-2-[(1S,4S)- or (1R,4R)-...)
Show SMILES OC(=O)C(F)(F)F.Clc1sccc1NC(=O)c1csc2ncc(nc12)N1C[C@@H]2CC[C@H]1CN2
Show InChI InChI=1S/C17H16ClN5OS2.C2HF3O2/c18-15-12(3-4-25-15)21-16(24)11-8-26-17-14(11)22-13(6-20-17)23-7-9-1-2-10(23)5-19-9;3-2(4,5)1(6)7/h3-4,6,8-10,19H,1-2,5,7H2,(H,21,24);(H,6,7)/t9-,10-;/m0./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278885
PNG
(N-(2-bromothiophen-3- yl)-2-[(1S,4S)- or (1R,4R)-2...)
Show SMILES OC(=O)C(F)(F)F.Brc1sccc1NC(=O)c1csc2ncc(nc12)N1C[C@H]2CC[C@@H]1CN2
Show InChI InChI=1S/C17H16BrN5OS2.C2HF3O2/c18-15-12(3-4-25-15)21-16(24)11-8-26-17-14(11)22-13(6-20-17)23-7-9-1-2-10(23)5-19-9;3-2(4,5)1(6)7/h3-4,6,8-10,19H,1-2,5,7H2,(H,21,24);(H,6,7)/t9-,10-;/m1./s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278867
PNG
(N-(4-bromothiophen-3- yl)-2-[(1S,4S)- or (1R,4R)-2...)
Show SMILES Brc1cscc1NC(=O)c1csc2ncc(nc12)N1C[C@@H]2CC[C@H]1CN2
Show InChI InChI=1S/C17H16BrN5OS2/c18-12-7-25-8-13(12)21-16(24)11-6-26-17-15(11)22-14(4-20-17)23-5-9-1-2-10(23)3-19-9/h4,6-10,19H,1-3,5H2,(H,21,24)/t9-,10-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278903
PNG
(N-(2- cyanophenyl)-2- (5,8-diazaspiro- [2.6]non-5-...)
Show SMILES OC(=O)C(F)(F)F.O=C(Nc1ccccc1C#N)c1csc2ncc(nc12)N1CCNCC2(CC2)C1
Show InChI InChI=1S/C21H20N6OS.C2HF3O2/c22-9-14-3-1-2-4-16(14)25-19(28)15-11-29-20-18(15)26-17(10-24-20)27-8-7-23-12-21(13-27)5-6-21;3-2(4,5)1(6)7/h1-4,10-11,23H,5-8,12-13H2,(H,25,28);(H,6,7)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278872
PNG
(N-(2-bromothiophen-3- yl)-2-(1,4-diazepan-1- yl)th...)
Show SMILES OC(=O)C(F)(F)F.Brc1sccc1NC(=O)c1csc2ncc(nc12)N1CCCNCC1
Show InChI InChI=1S/C16H16BrN5OS2.C2HF3O2/c17-14-11(2-7-24-14)20-15(23)10-9-25-16-13(10)21-12(8-19-16)22-5-1-3-18-4-6-22;3-2(4,5)1(6)7/h2,7-9,18H,1,3-6H2,(H,20,23);(H,6,7)
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n/an/a 1.16E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278896
PNG
(2-[(1S,4S)- or (1R,4R)- 2,5-diazabicyclo [2.2.2]oc...)
Show SMILES OC(=O)C(F)(F)F.FC(F)(F)c1sccc1NC(=O)c1csc2ncc(nc12)N1C[C@H]2CC[C@@H]1CN2
Show InChI InChI=1S/C18H16F3N5OS2.C2HF3O2/c19-18(20,21)15-12(3-4-28-15)24-16(27)11-8-29-17-14(11)25-13(6-23-17)26-7-9-1-2-10(26)5-22-9;3-2(4,5)1(6)7/h3-4,6,8-10,22H,1-2,5,7H2,(H,24,27);(H,6,7)/t9-,10-;/m1./s1
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n/an/a 1.23E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278881
PNG
(2-{[(1R,2R)-2-amino- 3,3-difluorocyclohexyl] amino...)
Show SMILES OC(=O)C(F)(F)F.N[C@@H]1[C@@H](CCCC1(F)F)Nc1cnc2scc(C(=O)Nc3ccsc3Cl)c2n1
Show InChI InChI=1S/C17H16ClF2N5OS2.C2HF3O2/c18-14-10(3-5-27-14)24-15(26)8-7-28-16-12(8)25-11(6-22-16)23-9-2-1-4-17(19,20)13(9)21;3-2(4,5)1(6)7/h3,5-7,9,13H,1-2,4,21H2,(H,23,25)(H,24,26);(H,6,7)/t9-,13-;/m1./s1
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n/an/a 1.41E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278919
PNG
(N-(2- chlorophenyl)-2- [(1S,4S)- or (1R,4R)-2,5- d...)
Show SMILES OC(=O)C(F)(F)F.Clc1ccccc1NC(=O)c1csc2ncc(nc12)N1C[C@@H]2CC[C@H]1CN2
Show InChI InChI=1S/C19H18ClN5OS.C2HF3O2/c20-14-3-1-2-4-15(14)23-18(26)13-10-27-19-17(13)24-16(8-22-19)25-9-11-5-6-12(25)7-21-11;3-2(4,5)1(6)7/h1-4,8,10-12,21H,5-7,9H2,(H,23,26);(H,6,7)/t11-,12-;/m0./s1
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n/an/a 1.56E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278894
PNG
(2-(1,4-diazepan-1-yl)- N-[2-(trifluoromethyl) thio...)
Show SMILES OC(=O)C(F)(F)F.FC(F)(F)c1sccc1NC(=O)c1csc2ncc(nc12)N1CCCNCC1
Show InChI InChI=1S/C17H16F3N5OS2.C2HF3O2/c18-17(19,20)14-11(2-7-27-14)23-15(26)10-9-28-16-13(10)24-12(8-22-16)25-5-1-3-21-4-6-25;3-2(4,5)1(6)7/h2,7-9,21H,1,3-6H2,(H,23,26);(H,6,7)
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n/an/a 1.59E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278916
PNG
(2-{[(1R,2R)- 2-amino-3,3- difluorocyclo- hexyl]ami...)
Show SMILES N[C@@H]1[C@@H](CCCC1(F)F)Nc1cnc2scc(C(=O)Nc3ccccc3Br)c2n1
Show InChI InChI=1S/C19H18BrF2N5OS/c20-11-4-1-2-5-12(11)26-17(28)10-9-29-18-15(10)27-14(8-24-18)25-13-6-3-7-19(21,22)16(13)23/h1-2,4-5,8-9,13,16H,3,6-7,23H2,(H,25,27)(H,26,28)/t13-,16-/m1/s1
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n/an/a 2.01E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278892
PNG
(2-{[(1R,2R)-2-amino- 3,3-difluorocyclohexyl] amino...)
Show SMILES OC(=O)C(F)(F)F.N[C@@H]1[C@@H](CCCC1(F)F)Nc1cnc2scc(C(=O)Nc3ccsc3Br)c2n1
Show InChI InChI=1S/C17H16BrF2N5OS2.C2HF3O2/c18-14-10(3-5-27-14)24-15(26)8-7-28-16-12(8)25-11(6-22-16)23-9-2-1-4-17(19,20)13(9)21;3-2(4,5)1(6)7/h3,5-7,9,13H,1-2,4,21H2,(H,23,25)(H,24,26);(H,6,7)/t9-,13-;/m1./s1
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n/an/a 2.07E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278889
PNG
(2-{[(1R,2R)-2-amino- 3,3-difluorocyclohexyl] amino...)
Show SMILES OC=O.N[C@@H]1[C@@H](CCCC1(F)F)Nc1cnc2scc(C(=O)Nc3cscc3Br)c2n1
Show InChI InChI=1S/C17H16BrF2N5OS2.CH2O2/c18-9-6-27-7-11(9)24-15(26)8-5-28-16-13(8)25-12(4-22-16)23-10-2-1-3-17(19,20)14(10)21;2-1-3/h4-7,10,14H,1-3,21H2,(H,23,25)(H,24,26);1H,(H,2,3)/t10-,14-;/m1./s1
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n/an/a 2.10E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278902
PNG
(N-(2- bromophenyl)- 2-(1,4-diazepan- 1-yl)thieno[2...)
Show SMILES OC(=O)C(F)(F)F.Brc1ccccc1NC(=O)c1csc2ncc(nc12)N1CCCNCC1
Show InChI InChI=1S/C18H18BrN5OS.C2HF3O2/c19-13-4-1-2-5-14(13)22-17(25)12-11-26-18-16(12)23-15(10-21-18)24-8-3-6-20-7-9-24;3-2(4,5)1(6)7/h1-2,4-5,10-11,20H,3,6-9H2,(H,22,25);(H,6,7)
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n/an/a 2.34E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278926
PNG
(2-{[(1R,2R)-2- amino-3,3- difluorocyclohexyl]- ami...)
Show SMILES OC(=O)C(F)(F)F.N[C@@H]1[C@@H](CCCC1(F)F)Nc1cnc2scc(C(=O)Nc3ccccc3C(F)F)c2n1
Show InChI InChI=1S/C20H19F4N5OS.C2HF3O2/c21-17(22)10-4-1-2-5-12(10)28-18(30)11-9-31-19-15(11)29-14(8-26-19)27-13-6-3-7-20(23,24)16(13)25;3-2(4,5)1(6)7/h1-2,4-5,8-9,13,16-17H,3,6-7,25H2,(H,27,29)(H,28,30);(H,6,7)/t13-,16-;/m1./s1
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n/an/a 2.58E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278908
PNG
(N-(2- bromophenyl)- 2-[(1S,4S)- or (1R,4R)-2,5- di...)
Show SMILES OC(=O)C(F)(F)F.Brc1ccccc1NC(=O)c1csc2ncc(nc12)N1C[C@@H]2CC[C@H]1CN2
Show InChI InChI=1S/C19H18BrN5OS.C2HF3O2/c20-14-3-1-2-4-15(14)23-18(26)13-10-27-19-17(13)24-16(8-22-19)25-9-11-5-6-12(25)7-21-11;3-2(4,5)1(6)7/h1-4,8,10-12,21H,5-7,9H2,(H,23,26);(H,6,7)/t11-,12-;/m0./s1
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n/an/a 2.87E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278923
PNG
(2-(1,4-diazepan- 1-yl)-N-[2- (difluoromethyl) phen...)
Show SMILES OC(=O)C(F)(F)F.FC(F)c1ccccc1NC(=O)c1csc2ncc(nc12)N1CCCNCC1
Show InChI InChI=1S/C19H19F2N5OS.C2HF3O2/c20-17(21)12-4-1-2-5-14(12)24-18(27)13-11-28-19-16(13)25-15(10-23-19)26-8-3-6-22-7-9-26;3-2(4,5)1(6)7/h1-2,4-5,10-11,17,22H,3,6-9H2,(H,24,27);(H,6,7)
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n/an/a 3.63E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278895
PNG
(2-[(1S,4S)- or (1R,4R)- 2,5-diazabicyclo [2.2.2]oc...)
Show SMILES OC(=O)C(F)(F)F.FC(F)(F)c1sccc1NC(=O)c1csc2ncc(nc12)N1C[C@@H]2CC[C@H]1CN2
Show InChI InChI=1S/C18H16F3N5OS2.C2HF3O2/c19-18(20,21)15-12(3-4-28-15)24-16(27)11-8-29-17-14(11)25-13(6-23-17)26-7-9-1-2-10(26)5-22-9;3-2(4,5)1(6)7/h3-4,6,8-10,22H,1-2,5,7H2,(H,24,27);(H,6,7)/t9-,10-;/m0./s1
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n/an/a 3.65E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278899
PNG
(2-{[(1R,2R)-2-amino- 3,3-difluorocyclohexyl] amino...)
Show SMILES OC(=O)C(F)(F)F.N[C@@H]1[C@@H](CCCC1(F)F)Nc1cnc2scc(C(=O)Nc3ccsc3C#N)c2n1
Show InChI InChI=1S/C18H16F2N6OS2.C2HF3O2/c19-18(20)4-1-2-11(15(18)22)24-13-7-23-17-14(26-13)9(8-29-17)16(27)25-10-3-5-28-12(10)6-21;3-2(4,5)1(6)7/h3,5,7-8,11,15H,1-2,4,22H2,(H,24,26)(H,25,27);(H,6,7)/t11-,15-;/m1./s1
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n/an/a 3.66E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278924
PNG
(2-[(1S,4S)- or (1R,4R)-2,5- diazabicyclo- [2.2.2]o...)
Show SMILES OC(=O)C(F)(F)F.FC(F)c1ccccc1NC(=O)c1csc2ncc(nc12)N1C[C@H]2CC[C@@H]1CN2
Show InChI InChI=1S/C20H19F2N5OS.C2HF3O2/c21-18(22)13-3-1-2-4-15(13)25-19(28)14-10-29-20-17(14)26-16(8-24-20)27-9-11-5-6-12(27)7-23-11;3-2(4,5)1(6)7/h1-4,8,10-12,18,23H,5-7,9H2,(H,25,28);(H,6,7)/t11-,12-;/m1./s1
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n/an/a 4.18E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM278910
PNG
(2-(1,4-diazepan- 1-yl)-N-[2- (trifluoromethyl) phe...)
Show SMILES OC(=O)C(F)(F)F.FC(F)(F)c1ccccc1NC(=O)c1csc2ncc(nc12)N1CCCNCC1
Show InChI InChI=1S/C19H18F3N5OS.C2HF3O2/c20-19(21,22)13-4-1-2-5-14(13)25-17(28)12-11-29-18-16(12)26-15(10-24-18)27-8-3-6-23-7-9-27;3-2(4,5)1(6)7/h1-2,4-5,10-11,23H,3,6-9H2,(H,25,28);(H,6,7)
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n/an/a 6.40E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10040802 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%