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Patent code US10040815

Compile Data Set for Download or QSAR
Found 21 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Toll-like receptor 7


(Homo sapiens (Human))
BDBM278954
PNG
(US10040815, Example 10-A)
Show SMILES CCCC(O)[C@@H]1C[C@@H](O)[C@@H](O1)n1c2nc(N)[nH]c(=O)c2sc1=O
UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
n/an/an/an/a 6.30E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
A stable HEK293-Blue-hTLR-7 cell line was purchased from InvivoGen (Cat.#: hkb-htlr7, San Diego, Calif., USA). These cells were designed for studying...


US Patent US10040815 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM278961
PNG
(3-[(2R,3R,5S)-3-allyl-5-(1-hydroxypropyl)tetrahydr...)
Show SMILES CCC(O)[C@@H]1C[C@@H](CC=C)[C@@H](O1)n1c2nc(N)[nH]c(=O)c2sc1=O
UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
n/an/an/an/a 2.90E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
A stable HEK293-Blue-hTLR-7 cell line was purchased from InvivoGen (Cat.#: hkb-htlr7, San Diego, Calif., USA). These cells were designed for studying...


US Patent US10040815 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM278967
PNG
(5-Amino-3-[(2R,3R,5S)-5-[(1S)-1-hydroxyethyl]-3-me...)
Show SMILES C[C@H](O)[C@@H]1C[C@@H](C)[C@@H](O1)n1c2nc(N)[nH]c(=O)c2sc1=O
UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
n/an/an/an/a 7.00E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
A stable HEK293-Blue-hTLR-7 cell line was purchased from InvivoGen (Cat.#: hkb-htlr7, San Diego, Calif., USA). These cells were designed for studying...


US Patent US10040815 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM278950
PNG
(US10040815, Example ANA-122)
Show SMILES Nc1nc2n([C@@H]3O[C@H](CO)C[C@H]3O)c(=O)sc2c(=O)[nH]1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
n/an/an/an/a 4.46E+5n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
A stable HEK293-Blue-hTLR-7 cell line was purchased from InvivoGen (Cat.#: hkb-htlr7, San Diego, Calif., USA). These cells were designed for studying...


US Patent US10040815 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM278957
PNG
(US10040815, Example 19-A)
Show SMILES CC#CC(O)[C@@H]1C[C@@H](O)[C@@H](O1)n1c2nc(N)[nH]c(=O)c2sc1=O
UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
n/an/an/an/a 3.80E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
A stable HEK293-Blue-hTLR-7 cell line was purchased from InvivoGen (Cat.#: hkb-htlr7, San Diego, Calif., USA). These cells were designed for studying...


US Patent US10040815 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM278958
PNG
(US10040815, Example 22-A)
Show SMILES CCC(O)[C@@H]1C[C@@H](SC)[C@@H](O1)n1c2nc(N)[nH]c(=O)c2sc1=O
UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
n/an/an/an/a 1.40E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
A stable HEK293-Blue-hTLR-7 cell line was purchased from InvivoGen (Cat.#: hkb-htlr7, San Diego, Calif., USA). These cells were designed for studying...


US Patent US10040815 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM278959
PNG
(US10040815, Example 23-A)
Show SMILES CCC(O)[C@@H]1C[C@@H](N=[N+]=[N-])[C@@H](O1)n1c2nc(N)[nH]c(=O)c2sc1=O
UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
n/an/an/an/a 2.60E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
A stable HEK293-Blue-hTLR-7 cell line was purchased from InvivoGen (Cat.#: hkb-htlr7, San Diego, Calif., USA). These cells were designed for studying...


US Patent US10040815 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM278970
PNG
(US10040815, Example 42 | [(1S)-1-[(2S,4R,5R)-5-(5-...)
Show SMILES CC[C@H](OC(=O)C(C)C)[C@@H]1C[C@@H](O)[C@@H](O1)n1c2nc(N)[nH]c(=O)c2sc1=O
UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
n/an/an/an/a 5.10E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
A stable HEK293-Blue-hTLR-7 cell line was purchased from InvivoGen (Cat.#: hkb-htlr7, San Diego, Calif., USA). These cells were designed for studying...


US Patent US10040815 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM278956
PNG
(US10040815, Example 18-A)
Show SMILES Nc1nc2n([C@@H]3O[C@@H](C[C@H]3O)C(O)C#C)c(=O)sc2c(=O)[nH]1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
n/an/an/an/a 1.20E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
A stable HEK293-Blue-hTLR-7 cell line was purchased from InvivoGen (Cat.#: hkb-htlr7, San Diego, Calif., USA). These cells were designed for studying...


US Patent US10040815 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM278963
PNG
(US10040815, Example 27-A)
Show SMILES CCC[C@@H]1C[C@H](O[C@H]1n1c2nc(N)[nH]c(=O)c2sc1=O)[C@@H](O)CC
UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
n/an/an/an/a 1.50E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
A stable HEK293-Blue-hTLR-7 cell line was purchased from InvivoGen (Cat.#: hkb-htlr7, San Diego, Calif., USA). These cells were designed for studying...


US Patent US10040815 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM278969
PNG
(5-Amino-3-[(2R,3R,5S)-5-(hydroxymethyl)-3-methylsu...)
Show SMILES CS[C@@H]1C[C@@H](CO)O[C@H]1n1c2nc(N)[nH]c(=O)c2sc1=O
UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
n/an/an/an/a 6.20E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
A stable HEK293-Blue-hTLR-7 cell line was purchased from InvivoGen (Cat.#: hkb-htlr7, San Diego, Calif., USA). These cells were designed for studying...


US Patent US10040815 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM278960
PNG
(US10040815, Example 24-A)
Show SMILES Nc1nc2n([C@@H]3O[C@@H](C[C@H]3O)C(O)C=C)c(=O)sc2c(=O)[nH]1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
n/an/an/an/a 7.00E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
A stable HEK293-Blue-hTLR-7 cell line was purchased from InvivoGen (Cat.#: hkb-htlr7, San Diego, Calif., USA). These cells were designed for studying...


US Patent US10040815 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM278961
PNG
(3-[(2R,3R,5S)-3-allyl-5-(1-hydroxypropyl)tetrahydr...)
Show SMILES CCC(O)[C@@H]1C[C@@H](CC=C)[C@@H](O1)n1c2nc(N)[nH]c(=O)c2sc1=O
UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
n/an/an/an/a 1.20E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
A stable HEK293-Blue-hTLR-7 cell line was purchased from InvivoGen (Cat.#: hkb-htlr7, San Diego, Calif., USA). These cells were designed for studying...


US Patent US10040815 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM278964
PNG
(5-amino-3-[(2R,3R,5S)-5-[(1S)-1-hydroxypropyl]-3-m...)
Show SMILES CCC(O)[C@@H]1C[C@@H](C)[C@@H](O1)n1c2nc(N)[nH]c(=O)c2sc1=O
UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
n/an/an/an/a 1.00E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
A stable HEK293-Blue-hTLR-7 cell line was purchased from InvivoGen (Cat.#: hkb-htlr7, San Diego, Calif., USA). These cells were designed for studying...


US Patent US10040815 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM278968
PNG
(5-Amino-3-[(2R,3R,5S)-5-(hydroxymethyl)-3-pyrrolid...)
Show SMILES Nc1nc2n([C@@H]3O[C@H](CO)C[C@H]3N3CCCC3)c(=O)sc2c(=O)[nH]1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
n/an/an/an/a 6.70E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
A stable HEK293-Blue-hTLR-7 cell line was purchased from InvivoGen (Cat.#: hkb-htlr7, San Diego, Calif., USA). These cells were designed for studying...


US Patent US10040815 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM278951
PNG
(US10040815, Example 1-A)
Show SMILES CCC(O)[C@@H]1C[C@@H](O)[C@@H](O1)n1c2nc(N)[nH]c(=O)c2sc1=O
UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
n/an/an/an/a 5.20E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
A stable HEK293-Blue-hTLR-7 cell line was purchased from InvivoGen (Cat.#: hkb-htlr7, San Diego, Calif., USA). These cells were designed for studying...


US Patent US10040815 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM278955
PNG
(US10040815, Example 14-A)
Show SMILES Nc1nc2n([C@@H]3O[C@@H](C[C@H]3O)C(O)C3CC3)c(=O)sc2c(=O)[nH]1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
n/an/an/an/a 4.80E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
A stable HEK293-Blue-hTLR-7 cell line was purchased from InvivoGen (Cat.#: hkb-htlr7, San Diego, Calif., USA). These cells were designed for studying...


US Patent US10040815 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM278966
PNG
(5-Amino-3-[(2R,3R,5S)-5-[(S)-cyclopropyl(hydroxy)m...)
Show SMILES C[C@@H]1C[C@H](O[C@H]1n1c2nc(N)[nH]c(=O)c2sc1=O)[C@@H](O)C1CC1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
n/an/an/an/a 1.50E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
A stable HEK293-Blue-hTLR-7 cell line was purchased from InvivoGen (Cat.#: hkb-htlr7, San Diego, Calif., USA). These cells were designed for studying...


US Patent US10040815 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM278952
PNG
(US10040815, Example 5-A)
Show SMILES CCC(O)[C@@H]1C[C@@H](OC(C)=O)[C@@H](O1)n1c2nc(N)[nH]c(=O)c2sc1=O
UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
n/an/an/an/a 4.80E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
A stable HEK293-Blue-hTLR-7 cell line was purchased from InvivoGen (Cat.#: hkb-htlr7, San Diego, Calif., USA). These cells were designed for studying...


US Patent US10040815 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM278953
PNG
(US10040815, Example 8-A)
Show SMILES Nc1nc2n([C@@H]3O[C@@H](C[C@H]3O)C(O)CC=C)c(=O)sc2c(=O)[nH]1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
n/an/an/an/a 8.70E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
A stable HEK293-Blue-hTLR-7 cell line was purchased from InvivoGen (Cat.#: hkb-htlr7, San Diego, Calif., USA). These cells were designed for studying...


US Patent US10040815 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM278965
PNG
(5-Amino-3-[(2R,3R,5S)-5-[(1S)-1-hydroxybut-2-ynyl]...)
Show SMILES CC#C[C@H](O)[C@@H]1C[C@@H](C)[C@@H](O1)n1c2nc(N)[nH]c(=O)c2sc1=O
UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
n/an/an/an/a 2.90E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
A stable HEK293-Blue-hTLR-7 cell line was purchased from InvivoGen (Cat.#: hkb-htlr7, San Diego, Calif., USA). These cells were designed for studying...


US Patent US10040815 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%