BindingDB logo
myBDB logout

Patent code US10047073

Compile Data Set for Download or QSAR
Found 12 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histone deacetylase 4


(Homo sapiens (Human))
BDBM228164
PNG
(US10047073, 6 | US10047073, 7)
Show SMILES FC(F)(F)c1nc(no1)-c1ccc(cc1)C(=O)NC1(CN2CCCC2C2CC2)CC1
Show InChI InChI=1S/C21H23F3N4O2/c22-21(23,24)19-25-17(27-30-19)14-5-7-15(8-6-14)18(29)26-20(9-10-20)12-28-11-1-2-16(28)13-3-4-13/h5-8,13,16H,1-4,9-12H2,(H,26,29)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 3n/an/an/an/an/an/a



CHDI FOUNDATION, INC

US Patent


Assay Description
The Class I HDAC activity of Class IIa Histone Deacetylase (HDAC) inhibitors was quantified by measuring the cellular histone deacetylase enzymatic a...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM228164
PNG
(US10047073, 6 | US10047073, 7)
Show SMILES FC(F)(F)c1nc(no1)-c1ccc(cc1)C(=O)NC1(CN2CCCC2C2CC2)CC1
Show InChI InChI=1S/C21H23F3N4O2/c22-21(23,24)19-25-17(27-30-19)14-5-7-15(8-6-14)18(29)26-20(9-10-20)12-28-11-1-2-16(28)13-3-4-13/h5-8,13,16H,1-4,9-12H2,(H,26,29)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 8n/an/an/an/an/an/a



CHDI FOUNDATION, INC

US Patent


Assay Description
The Class I HDAC activity of Class IIa Histone Deacetylase (HDAC) inhibitors was quantified by measuring the cellular histone deacetylase enzymatic a...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM228166
PNG
(US10047073, 8)
Show SMILES CC1(C)CCC[NH+](CC2(CC2)NC(=O)c2ccc(cc2)-c2noc(n2)C(F)(F)F)C1
Show InChI InChI=1S/C21H25F3N4O2/c1-19(2)8-3-11-28(12-19)13-20(9-10-20)26-17(29)15-6-4-14(5-7-15)16-25-18(30-27-16)21(22,23)24/h4-7H,3,8-13H2,1-2H3,(H,26,29)/p+1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 30n/an/an/an/an/an/a



CHDI FOUNDATION, INC

US Patent


Assay Description
The Class I HDAC activity of Class IIa Histone Deacetylase (HDAC) inhibitors was quantified by measuring the cellular histone deacetylase enzymatic a...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM228159
PNG
(US10047073, 1)
Show SMILES FC(F)(F)c1nc(no1)-c1ccc(cc1)C(=O)NC1(CN2CCCC3(CC3)C2)CC1
Show InChI InChI=1S/C21H23F3N4O2/c22-21(23,24)18-25-16(27-30-18)14-2-4-15(5-3-14)17(29)26-20(9-10-20)13-28-11-1-6-19(12-28)7-8-19/h2-5H,1,6-13H2,(H,26,29)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a



CHDI FOUNDATION, INC

US Patent


Assay Description
The Class I HDAC activity of Class IIa Histone Deacetylase (HDAC) inhibitors was quantified by measuring the cellular histone deacetylase enzymatic a...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM228169
PNG
(US10047073, 9)
Show SMILES FC(F)(F)c1nc(no1)-c1ccc(cc1)C(=O)NC1(CN2CCC3(CC3)C2)CCC1
Show InChI InChI=1S/C21H23F3N4O2/c22-21(23,24)18-25-16(27-30-18)14-2-4-15(5-3-14)17(29)26-20(6-1-7-20)13-28-11-10-19(12-28)8-9-19/h2-5H,1,6-13H2,(H,26,29)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 58n/an/an/an/an/an/a



CHDI FOUNDATION, INC

US Patent


Assay Description
The Class I HDAC activity of Class IIa Histone Deacetylase (HDAC) inhibitors was quantified by measuring the cellular histone deacetylase enzymatic a...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM228173
PNG
(US10047073, 12)
Show SMILES CC1(C)CCCN(CC2(CC2)NC(=O)c2ccc(-c3noc(n3)C(F)(F)F)c(F)c2)C1
Show InChI InChI=1S/C21H24F4N4O2/c1-19(2)6-3-9-29(11-19)12-20(7-8-20)27-17(30)13-4-5-14(15(22)10-13)16-26-18(31-28-16)21(23,24)25/h4-5,10H,3,6-9,11-12H2,1-2H3,(H,27,30)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 76n/an/an/an/an/an/a



CHDI FOUNDATION, INC

US Patent


Assay Description
The Class I HDAC activity of Class IIa Histone Deacetylase (HDAC) inhibitors was quantified by measuring the cellular histone deacetylase enzymatic a...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM228163
PNG
(US10047073, 5)
Show SMILES FC(F)(F)c1nc(no1)-c1ccc(cc1)C(=O)NC1(CN2CCC3(CC3)CC2)CC1
Show InChI InChI=1S/C21H23F3N4O2/c22-21(23,24)18-25-16(27-30-18)14-1-3-15(4-2-14)17(29)26-20(7-8-20)13-28-11-9-19(5-6-19)10-12-28/h1-4H,5-13H2,(H,26,29)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 89n/an/an/an/an/an/a



CHDI FOUNDATION, INC

US Patent


Assay Description
The Class I HDAC activity of Class IIa Histone Deacetylase (HDAC) inhibitors was quantified by measuring the cellular histone deacetylase enzymatic a...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM228160
PNG
(US10047073, 2)
Show SMILES FC(F)(F)c1nc(no1)-c1ccc(cc1)C(=O)NC1(CN2CCC3(COC3)CC2)CC1
Show InChI InChI=1S/C21H23F3N4O3/c22-21(23,24)18-25-16(27-31-18)14-1-3-15(4-2-14)17(29)26-20(5-6-20)11-28-9-7-19(8-10-28)12-30-13-19/h1-4H,5-13H2,(H,26,29)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 110n/an/an/an/an/an/a



CHDI FOUNDATION, INC

US Patent


Assay Description
The Class I HDAC activity of Class IIa Histone Deacetylase (HDAC) inhibitors was quantified by measuring the cellular histone deacetylase enzymatic a...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM228172
PNG
(US10047073, 11)
Show SMILES C[C@H]1CCC[NH+]1CC1CC1NC(=O)c1ccc(cc1)-c1noc(n1)C(F)(F)F
Show InChI InChI=1S/C19H21F3N4O2/c1-11-3-2-8-26(11)10-14-9-15(14)23-17(27)13-6-4-12(5-7-13)16-24-18(28-25-16)19(20,21)22/h4-7,11,14-15H,2-3,8-10H2,1H3,(H,23,27)/p+1/t11-,14?,15?/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 230n/an/an/an/an/an/a



CHDI FOUNDATION, INC

US Patent


Assay Description
The Class I HDAC activity of Class IIa Histone Deacetylase (HDAC) inhibitors was quantified by measuring the cellular histone deacetylase enzymatic a...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM228162
PNG
(US10047073, 4)
Show SMILES FC(F)(F)c1nc(no1)-c1ccc(cc1)C(=O)NC1(CN2CC3CCC(C3)C2)CC1
Show InChI InChI=1S/C21H23F3N4O2/c22-21(23,24)19-25-17(27-30-19)15-3-5-16(6-4-15)18(29)26-20(7-8-20)12-28-10-13-1-2-14(9-13)11-28/h3-6,13-14H,1-2,7-12H2,(H,26,29)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 330n/an/an/an/an/an/a



CHDI FOUNDATION, INC

US Patent


Assay Description
The Class I HDAC activity of Class IIa Histone Deacetylase (HDAC) inhibitors was quantified by measuring the cellular histone deacetylase enzymatic a...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM228161
PNG
(US10047073, 3)
Show SMILES FC(F)(F)c1nc(no1)-c1ccc(cc1)C(=O)NC1(CN2CCCC22COC2)CCC1
Show InChI InChI=1S/C21H23F3N4O3/c22-21(23,24)18-25-16(27-31-18)14-3-5-15(6-4-14)17(29)26-19(7-1-8-19)11-28-10-2-9-20(28)12-30-13-20/h3-6H,1-2,7-13H2,(H,26,29)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 750n/an/an/an/an/an/a



CHDI FOUNDATION, INC

US Patent


Assay Description
The Class I HDAC activity of Class IIa Histone Deacetylase (HDAC) inhibitors was quantified by measuring the cellular histone deacetylase enzymatic a...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM228171
PNG
(US10047073, 10)
Show SMILES FC(F)(F)c1nc(no1)-c1ccc(cc1)C(=O)NC1(CN2CCCC22COC2)CC1
Show InChI InChI=1S/C20H21F3N4O3/c21-20(22,23)17-24-15(26-30-17)13-2-4-14(5-3-13)16(28)25-18(7-8-18)10-27-9-1-6-19(27)11-29-12-19/h2-5H,1,6-12H2,(H,25,28)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 750n/an/an/an/an/an/a



CHDI FOUNDATION, INC

US Patent


Assay Description
The Class I HDAC activity of Class IIa Histone Deacetylase (HDAC) inhibitors was quantified by measuring the cellular histone deacetylase enzymatic a...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%