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Patent code US10052306

Compile Data Set for Download or QSAR

Found 333 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glutamate [NMDA] receptor


(Homo sapiens)
BDBM237334
PNG
((3aR,5R,6aS)-5-benzyl-2- ((R)-2-(3-fluoro-4- hydro...)
Show SMILES O[C@@H](CN1C[C@H]2C[C@](O)(Cc3ccccc3)C[C@H]2C1)c1ccc(O)c(F)c1
Show InChI InChI=1S/C22H26FNO3/c23-19-8-16(6-7-20(19)25)21(26)14-24-12-17-10-22(27,11-18(17)13-24)9-15-4-2-1-3-5-15/h1-8,17-18,21,25-27H,9-14H2/t17-,18+,21-,22-/m0/s1
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n/an/a 0n/an/an/an/an/an/a



CADENT THERAPEUTICS, INC.

US Patent


Assay Description
To each well of the plate, 10 μL test compound, control (MK801) or HHnoCa buffer was added to a final concentration of 10 μM with a final c...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor


(Homo sapiens)
BDBM237552
PNG
(US10052306, 223 | rac-(3aR,5r,6aS)-5-(4- chloroben...)
Show SMILES OC(CN1C[C@H]2C[C@](O)(Cc3ccc(Cl)cc3)C[C@H]2C1)c1ccc(O)cn1
Show InChI InChI=1S/C21H25ClN2O3/c22-17-3-1-14(2-4-17)7-21(27)8-15-11-24(12-16(15)9-21)13-20(26)19-6-5-18(25)10-23-19/h1-6,10,15-16,20,25-27H,7-9,11-13H2/t15-,16+,20?,21-
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n/an/a 11.5n/an/an/an/an/an/a



CADENT THERAPEUTICS, INC.

US Patent


Assay Description
To each well of the plate, 10 μL test compound, control (MK801) or HHnoCa buffer was added to a final concentration of 10 μM with a final c...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor


(Homo sapiens)
BDBM238867
PNG
(US10052306, 306 | rac-4-{2-[(3aR,5R,6aS)- 5-benzyl...)
Show SMILES OC(CN1C[C@@H]2C[C@@H](Cc3ccccc3)C[C@@H]2C1)c1ccc(O)cc1
Show InChI InChI=1S/C22H27NO2/c24-21-8-6-18(7-9-21)22(25)15-23-13-19-11-17(12-20(19)14-23)10-16-4-2-1-3-5-16/h1-9,17,19-20,22,24-25H,10-15H2/t17-,19+,20-,22?
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n/an/a 11.7n/an/an/an/an/an/a



CADENT THERAPEUTICS, INC.

US Patent


Assay Description
To each well of the plate, 10 μL test compound, control (MK801) or HHnoCa buffer was added to a final concentration of 10 μM with a final c...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor


(Homo sapiens)
BDBM238862
PNG
(US10052306, 301 | rac-4-{2-[(3aR,5S,6aS)- 5-benzyl...)
Show SMILES OC(CN1C[C@@H]2C[C@H](Cc3ccccc3)C[C@@H]2C1)c1ccc(O)c(F)c1
Show InChI InChI=1S/C22H26FNO2/c23-20-11-17(6-7-21(20)25)22(26)14-24-12-18-9-16(10-19(18)13-24)8-15-4-2-1-3-5-15/h1-7,11,16,18-19,22,25-26H,8-10,12-14H2/t16-,18-,19+,22?
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n/an/a 12.2n/an/an/an/an/an/a



CADENT THERAPEUTICS, INC.

US Patent


Assay Description
To each well of the plate, 10 μL test compound, control (MK801) or HHnoCa buffer was added to a final concentration of 10 μM with a final c...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor


(Homo sapiens)
BDBM237388
PNG
(US10052306, 204 | rac-(3aR,5r,6aS)-2-(2- hydroxy-2...)
Show SMILES OC(CN1C[C@H]2C[C@](O)(Cc3cccs3)C[C@H]2C1)c1ccc(O)cc1
Show InChI InChI=1S/C20H25NO3S/c22-17-5-3-14(4-6-17)19(23)13-21-11-15-8-20(24,9-16(15)12-21)10-18-2-1-7-25-18/h1-7,15-16,19,22-24H,8-13H2/t15-,16+,19?,20-
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n/an/a 12.6n/an/an/an/an/an/a



CADENT THERAPEUTICS, INC.

US Patent


Assay Description
To each well of the plate, 10 μL test compound, control (MK801) or HHnoCa buffer was added to a final concentration of 10 μM with a final c...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor


(Homo sapiens)
BDBM238861
PNG
(US10052306, 300 | rac-4-(2-((3aR,6aS)-5- benzylhex...)
Show SMILES OC(CN1C[C@@H]2CC(Cc3ccccc3)C[C@@H]2C1)c1ccc(O)cc1
Show InChI InChI=1S/C22H27NO2/c24-21-8-6-18(7-9-21)22(25)15-23-13-19-11-17(12-20(19)14-23)10-16-4-2-1-3-5-16/h1-9,17,19-20,22,24-25H,10-15H2/t17?,19-,20+,22?
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n/an/a 13.9n/an/an/an/an/an/a



CADENT THERAPEUTICS, INC.

US Patent


Assay Description
To each well of the plate, 10 μL test compound, control (MK801) or HHnoCa buffer was added to a final concentration of 10 μM with a final c...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor


(Homo sapiens)
BDBM237683
PNG
(US10052306, 229 | rac-(3aR,5r,6aS)-5-(2- fluoroben...)
Show SMILES OC(CN1C[C@H]2C[C@](O)(Cc3ccccc3F)C[C@H]2C1)c1ccc(O)cc1
Show InChI InChI=1S/C22H26FNO3/c23-20-4-2-1-3-16(20)9-22(27)10-17-12-24(13-18(17)11-22)14-21(26)15-5-7-19(25)8-6-15/h1-8,17-18,21,25-27H,9-14H2/t17-,18+,21?,22-
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n/an/a 15.5n/an/an/an/an/an/a



CADENT THERAPEUTICS, INC.

US Patent


Assay Description
To each well of the plate, 10 μL test compound, control (MK801) or HHnoCa buffer was added to a final concentration of 10 μM with a final c...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor


(Homo sapiens)
BDBM238865
PNG
(US10052306, 304 | rac-4-{2-[(3aR,5S,6aS)- 5-benzyl...)
Show SMILES OC(CN1C[C@@H]2C[C@H](Cc3ccccc3)C[C@@H]2C1)c1ccc(O)cc1
Show InChI InChI=1S/C22H27NO2/c24-21-8-6-18(7-9-21)22(25)15-23-13-19-11-17(12-20(19)14-23)10-16-4-2-1-3-5-16/h1-9,17,19-20,22,24-25H,10-15H2/t17-,19-,20+,22?
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n/an/a 16.8n/an/an/an/an/an/a



CADENT THERAPEUTICS, INC.

US Patent


Assay Description
To each well of the plate, 10 μL test compound, control (MK801) or HHnoCa buffer was added to a final concentration of 10 μM with a final c...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor


(Homo sapiens)
BDBM235335
PNG
(US10052306, 131 | US10052306, 281 | rac-(3aR,5r,6a...)
Show SMILES OC(CN1C[C@H]2C[C@](O)(Cc3ccccc3)C[C@H]2C1)c1ccc(O)cc1
Show InChI InChI=1S/C22H27NO3/c24-20-8-6-17(7-9-20)21(25)15-23-13-18-11-22(26,12-19(18)14-23)10-16-4-2-1-3-5-16/h1-9,18-19,21,24-26H,10-15H2/t18-,19+,21?,22-
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n/an/a 17.4n/an/an/an/an/an/a



CADENT THERAPEUTICS, INC.

US Patent


Assay Description
To each well of the plate, 10 μL test compound, control (MK801) or HHnoCa buffer was added to a final concentration of 10 μM with a final c...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor


(Homo sapiens)
BDBM237322
PNG
(US10052306, 168 | rac-(3aR,5r,6aS)-5-(4- fluoroben...)
Show SMILES OC(CN1C[C@H]2C[C@](O)(Cc3ccc(F)cc3)C[C@H]2C1)c1ccc(O)cn1
Show InChI InChI=1S/C21H25FN2O3/c22-17-3-1-14(2-4-17)7-21(27)8-15-11-24(12-16(15)9-21)13-20(26)19-6-5-18(25)10-23-19/h1-6,10,15-16,20,25-27H,7-9,11-13H2/t15-,16+,20?,21-
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n/an/a 17.8n/an/an/an/an/an/a



CADENT THERAPEUTICS, INC.

US Patent


Assay Description
To each well of the plate, 10 μL test compound, control (MK801) or HHnoCa buffer was added to a final concentration of 10 μM with a final c...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor


(Homo sapiens)
BDBM237551
PNG
(US10052306, 222 | rac-2-(2-(3-fluoro-4- hydroxyphe...)
Show SMILES OC(CN1C[C@H]2C[C@](O)(Cc3cccs3)C[C@H]2C1)c1ccc(O)c(F)c1
Show InChI InChI=1S/C20H24FNO3S/c21-17-6-13(3-4-18(17)23)19(24)12-22-10-14-7-20(25,8-15(14)11-22)9-16-2-1-5-26-16/h1-6,14-15,19,23-25H,7-12H2/t14-,15+,19?,20-
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n/an/a 19.3n/an/an/an/an/an/a



CADENT THERAPEUTICS, INC.

US Patent


Assay Description
To each well of the plate, 10 μL test compound, control (MK801) or HHnoCa buffer was added to a final concentration of 10 μM with a final c...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor


(Homo sapiens)
BDBM238863
PNG
(US10052306, 302 | rac-4-{2-[(3aR,5R,6aS)- 5-benzyl...)
Show SMILES OC(CN1C[C@@H]2C[C@@H](Cc3ccccc3)C[C@@H]2C1)c1ccc(O)c(F)c1
Show InChI InChI=1S/C22H26FNO2/c23-20-11-17(6-7-21(20)25)22(26)14-24-12-18-9-16(10-19(18)13-24)8-15-4-2-1-3-5-15/h1-7,11,16,18-19,22,25-26H,8-10,12-14H2/t16-,18+,19-,22?
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n/an/a 20.1n/an/an/an/an/an/a



CADENT THERAPEUTICS, INC.

US Patent


Assay Description
To each well of the plate, 10 μL test compound, control (MK801) or HHnoCa buffer was added to a final concentration of 10 μM with a final c...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor


(Homo sapiens)
BDBM235341
PNG
((3aR,5S,6aS)-5-benzyl-2- ((S)-2-hydroxy-2-(4- hydr...)
Show SMILES O[C@H](CN1C[C@H]2C[C@](O)(Cc3ccccc3)C[C@H]2C1)c1ccc(O)cc1
Show InChI InChI=1S/C22H27NO3/c24-20-8-6-17(7-9-20)21(25)15-23-13-18-11-22(26,12-19(18)14-23)10-16-4-2-1-3-5-16/h1-9,18-19,21,24-26H,10-15H2/t18-,19+,21-,22-/m1/s1
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n/an/a 20.4n/an/an/an/an/an/a



CADENT THERAPEUTICS, INC.

US Patent


Assay Description
To each well of the plate, 10 μL test compound, control (MK801) or HHnoCa buffer was added to a final concentration of 10 μM with a final c...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor


(Homo sapiens)
BDBM235341
PNG
((3aR,5S,6aS)-5-benzyl-2- ((S)-2-hydroxy-2-(4- hydr...)
Show SMILES O[C@H](CN1C[C@H]2C[C@](O)(Cc3ccccc3)C[C@H]2C1)c1ccc(O)cc1
Show InChI InChI=1S/C22H27NO3/c24-20-8-6-17(7-9-20)21(25)15-23-13-18-11-22(26,12-19(18)14-23)10-16-4-2-1-3-5-16/h1-9,18-19,21,24-26H,10-15H2/t18-,19+,21-,22-/m1/s1
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n/an/a 20.4n/an/an/an/an/an/a



CADENT THERAPEUTICS, INC.

US Patent


Assay Description
To each well of the plate, 10 μL test compound, control (MK801) or HHnoCa buffer was added to a final concentration of 10 μM with a final c...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor


(Homo sapiens)
BDBM237325
PNG
(US10052306, 171 | rac-(3aR,5r,6aS)-2-(2-(3- fluoro...)
Show SMILES OC(CN1C[C@H]2C[C@](O)(Cc3ccc(F)cc3)C[C@H]2C1)c1ccc(O)c(F)c1
Show InChI InChI=1S/C22H25F2NO3/c23-18-4-1-14(2-5-18)8-22(28)9-16-11-25(12-17(16)10-22)13-21(27)15-3-6-20(26)19(24)7-15/h1-7,16-17,21,26-28H,8-13H2/t16-,17+,21?,22-
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n/an/a 22.1n/an/an/an/an/an/a



CADENT THERAPEUTICS, INC.

US Patent


Assay Description
To each well of the plate, 10 μL test compound, control (MK801) or HHnoCa buffer was added to a final concentration of 10 μM with a final c...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor


(Homo sapiens)
BDBM238859
PNG
(US10052306, 298 | rac-6-(2-{5-benzyl- octahydrocyc...)
Show SMILES OC(CN1C[C@@H]2CC(Cc3ccccc3)C[C@@H]2C1)c1ccc(O)cn1
Show InChI InChI=1S/C21H26N2O2/c24-19-6-7-20(22-11-19)21(25)14-23-12-17-9-16(10-18(17)13-23)8-15-4-2-1-3-5-15/h1-7,11,16-18,21,24-25H,8-10,12-14H2/t16?,17-,18+,21?
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n/an/a 22.4n/an/an/an/an/an/a



CADENT THERAPEUTICS, INC.

US Patent


Assay Description
To each well of the plate, 10 μL test compound, control (MK801) or HHnoCa buffer was added to a final concentration of 10 μM with a final c...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor


(Homo sapiens)
BDBM235340
PNG
((3aR,5R,6aS)-5-benzyl-2- ((R)-2-hydroxy-2-(4- hydr...)
Show SMILES O[C@@H](CN1C[C@H]2C[C@](O)(Cc3ccccc3)C[C@H]2C1)c1ccc(O)cc1
Show InChI InChI=1S/C22H27NO3/c24-20-8-6-17(7-9-20)21(25)15-23-13-18-11-22(26,12-19(18)14-23)10-16-4-2-1-3-5-16/h1-9,18-19,21,24-26H,10-15H2/t18-,19+,21-,22-/m0/s1
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n/an/a 23.7n/an/an/an/an/an/a



CADENT THERAPEUTICS, INC.

US Patent


Assay Description
To each well of the plate, 10 μL test compound, control (MK801) or HHnoCa buffer was added to a final concentration of 10 μM with a final c...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor


(Homo sapiens)
BDBM235340
PNG
((3aR,5R,6aS)-5-benzyl-2- ((R)-2-hydroxy-2-(4- hydr...)
Show SMILES O[C@@H](CN1C[C@H]2C[C@](O)(Cc3ccccc3)C[C@H]2C1)c1ccc(O)cc1
Show InChI InChI=1S/C22H27NO3/c24-20-8-6-17(7-9-20)21(25)15-23-13-18-11-22(26,12-19(18)14-23)10-16-4-2-1-3-5-16/h1-9,18-19,21,24-26H,10-15H2/t18-,19+,21-,22-/m0/s1
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n/an/a 23.7n/an/an/an/an/an/a



CADENT THERAPEUTICS, INC.

US Patent


Assay Description
To each well of the plate, 10 μL test compound, control (MK801) or HHnoCa buffer was added to a final concentration of 10 μM with a final c...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor


(Homo sapiens)
BDBM237699
PNG
(US10052306, 245 | rac-5-(2,4- difluorobenzyl)-2-(2...)
Show SMILES OC(CN1C[C@H]2C[C@](O)(Cc3ccc(F)cc3F)C[C@H]2C1)c1ccc(O)cc1
Show InChI InChI=1S/C22H25F2NO3/c23-18-4-1-15(20(24)7-18)8-22(28)9-16-11-25(12-17(16)10-22)13-21(27)14-2-5-19(26)6-3-14/h1-7,16-17,21,26-28H,8-13H2/t16-,17+,21?,22-
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n/an/a 23.8n/an/an/an/an/an/a



CADENT THERAPEUTICS, INC.

US Patent


Assay Description
To each well of the plate, 10 μL test compound, control (MK801) or HHnoCa buffer was added to a final concentration of 10 μM with a final c...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor


(Homo sapiens)
BDBM237709
PNG
((3aR,5S,6aS)-5-(4- fluorobenzyl)-2-((S)-2- hydroxy...)
Show SMILES O[C@@H](CN1C[C@H]2C[C@](O)(Cc3ccc(F)cc3)C[C@H]2C1)c1ccc(O)cn1
Show InChI InChI=1S/C21H25FN2O3/c22-17-3-1-14(2-4-17)7-21(27)8-15-11-24(12-16(15)9-21)13-20(26)19-6-5-18(25)10-23-19/h1-6,10,15-16,20,25-27H,7-9,11-13H2/t15-,16+,20-,21-/m0/s1
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n/an/a 24n/an/an/an/an/an/a



CADENT THERAPEUTICS, INC.

US Patent


Assay Description
To each well of the plate, 10 μL test compound, control (MK801) or HHnoCa buffer was added to a final concentration of 10 μM with a final c...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor


(Homo sapiens)
BDBM235335
PNG
(US10052306, 131 | US10052306, 281 | rac-(3aR,5r,6a...)
Show SMILES OC(CN1C[C@H]2C[C@](O)(Cc3ccccc3)C[C@H]2C1)c1ccc(O)cc1
Show InChI InChI=1S/C22H27NO3/c24-20-8-6-17(7-9-20)21(25)15-23-13-18-11-22(26,12-19(18)14-23)10-16-4-2-1-3-5-16/h1-9,18-19,21,24-26H,10-15H2/t18-,19+,21?,22-
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n/an/a 25.5n/an/an/an/an/an/a



CADENT THERAPEUTICS, INC.

US Patent


Assay Description
To each well of the plate, 10 μL test compound, control (MK801) or HHnoCa buffer was added to a final concentration of 10 μM with a final c...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor


(Homo sapiens)
BDBM237544
PNG
(US10052306, 215 | rac-2-(2-hydroxy-2-(5- hydroxypy...)
Show SMILES OC(CN1C[C@H]2C[C@](O)(Cc3cccs3)C[C@H]2C1)c1ccc(O)cn1
Show InChI InChI=1S/C19H24N2O3S/c22-15-3-4-17(20-9-15)18(23)12-21-10-13-6-19(24,7-14(13)11-21)8-16-2-1-5-25-16/h1-5,9,13-14,18,22-24H,6-8,10-12H2/t13-,14+,18?,19-
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n/an/a 25.7n/an/an/an/an/an/a



CADENT THERAPEUTICS, INC.

US Patent


Assay Description
To each well of the plate, 10 μL test compound, control (MK801) or HHnoCa buffer was added to a final concentration of 10 μM with a final c...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor


(Homo sapiens)
BDBM235352
PNG
(US10052306, 144 | rac- (3aR,5r,6aS)-5- benzyl-2-(2...)
Show SMILES OC(CN1C[C@H]2C[C@](O)(Cc3ccccc3)C[C@H]2C1)c1ccc(O)cn1
Show InChI InChI=1S/C21H26N2O3/c24-18-6-7-19(22-11-18)20(25)14-23-12-16-9-21(26,10-17(16)13-23)8-15-4-2-1-3-5-15/h1-7,11,16-17,20,24-26H,8-10,12-14H2/t16-,17+,20?,21-
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n/an/a 26.8n/an/an/an/an/an/a



CADENT THERAPEUTICS, INC.

US Patent


Assay Description
To each well of the plate, 10 μL test compound, control (MK801) or HHnoCa buffer was added to a final concentration of 10 μM with a final c...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor


(Homo sapiens)
BDBM238874
PNG
(US10052306, 313 | rac-4-(2-((3aR,5r,6aS)-5- benzyl...)
Show SMILES OC(CN1C[C@H]2C[C@](F)(Cc3ccccc3)C[C@H]2C1)c1ccc(O)cc1
Show InChI InChI=1S/C22H26FNO2/c23-22(10-16-4-2-1-3-5-16)11-18-13-24(14-19(18)12-22)15-21(26)17-6-8-20(25)9-7-17/h1-9,18-19,21,25-26H,10-15H2/t18-,19+,21?,22-
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n/an/a 26.9n/an/an/an/an/an/a



CADENT THERAPEUTICS, INC.

US Patent


Assay Description
To each well of the plate, 10 μL test compound, control (MK801) or HHnoCa buffer was added to a final concentration of 10 μM with a final c...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor


(Homo sapiens)
BDBM235339
PNG
(US10052306, 135 | rac-(3aR,5r,6aS)-5-(4- fluoroben...)
Show SMILES OC(CN1C[C@H]2C[C@](O)(Cc3ccc(F)cc3)C[C@H]2C1)c1ccc(O)cc1
Show InChI InChI=1S/C22H26FNO3/c23-19-5-1-15(2-6-19)9-22(27)10-17-12-24(13-18(17)11-22)14-21(26)16-3-7-20(25)8-4-16/h1-8,17-18,21,25-27H,9-14H2/t17-,18+,21?,22-
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n/an/a 27.1n/an/an/an/an/an/a



CADENT THERAPEUTICS, INC.

US Patent


Assay Description
To each well of the plate, 10 μL test compound, control (MK801) or HHnoCa buffer was added to a final concentration of 10 μM with a final c...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor


(Homo sapiens)
BDBM237554
PNG
(2-((3aR,5r,6aS)-5-(2- fluorobenzyl)-5- hydroxyhexa...)
Show SMILES Oc1ccc(cc1)C(=O)CN1C[C@H]2C[C@](O)(Cc3ccccc3F)C[C@H]2C1
Show InChI InChI=1S/C22H24FNO3/c23-20-4-2-1-3-16(20)9-22(27)10-17-12-24(13-18(17)11-22)14-21(26)15-5-7-19(25)8-6-15/h1-8,17-18,25,27H,9-14H2/t17-,18+,22-
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n/an/a 27.3n/an/an/an/an/an/a



CADENT THERAPEUTICS, INC.

US Patent


Assay Description
To each well of the plate, 10 μL test compound, control (MK801) or HHnoCa buffer was added to a final concentration of 10 μM with a final c...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor


(Homo sapiens)
BDBM237379
PNG
(US10052306, 195 | rac-(3aR,5r,6aS)-2-(2- hydroxy-2...)
Show SMILES COc1cccc(C[C@@]2(O)C[C@@H]3CN(CC(O)c4ccc(O)cc4)C[C@@H]3C2)c1
Show InChI InChI=1S/C23H29NO4/c1-28-21-4-2-3-16(9-21)10-23(27)11-18-13-24(14-19(18)12-23)15-22(26)17-5-7-20(25)8-6-17/h2-9,18-19,22,25-27H,10-15H2,1H3/t18-,19+,22?,23-
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n/an/a 28.7n/an/an/an/an/an/a



CADENT THERAPEUTICS, INC.

US Patent


Assay Description
To each well of the plate, 10 μL test compound, control (MK801) or HHnoCa buffer was added to a final concentration of 10 μM with a final c...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor


(Homo sapiens)
BDBM237687
PNG
(US10052306, 233 | rac-(3aR,5r,6aS)-5-(2,4- difluor...)
Show SMILES OC(CN1C[C@H]2C[C@](O)(Cc3ccc(F)cc3F)C[C@H]2C1)c1ccc(O)cn1
Show InChI InChI=1S/C21H24F2N2O3/c22-16-2-1-13(18(23)5-16)6-21(28)7-14-10-25(11-15(14)8-21)12-20(27)19-4-3-17(26)9-24-19/h1-5,9,14-15,20,26-28H,6-8,10-12H2/t14-,15+,20?,21-
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n/an/a 29.9n/an/an/an/an/an/a



CADENT THERAPEUTICS, INC.

US Patent


Assay Description
To each well of the plate, 10 μL test compound, control (MK801) or HHnoCa buffer was added to a final concentration of 10 μM with a final c...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor


(Homo sapiens)
BDBM236487
PNG
((3aR,5S,6aS)-5-benzyl-2- ((S)-2-(3-fluoro-4- hydro...)
Show SMILES O[C@H](CN1C[C@H]2C[C@](O)(Cc3ccccc3)C[C@H]2C1)c1ccc(O)c(F)c1
Show InChI InChI=1S/C22H26FNO3/c23-19-8-16(6-7-20(19)25)21(26)14-24-12-17-10-22(27,11-18(17)13-24)9-15-4-2-1-3-5-15/h1-8,17-18,21,25-27H,9-14H2/t17-,18+,21-,22-/m1/s1
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n/an/a 30.5n/an/an/an/an/an/a



CADENT THERAPEUTICS, INC.

US Patent


Assay Description
To each well of the plate, 10 μL test compound, control (MK801) or HHnoCa buffer was added to a final concentration of 10 μM with a final c...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor


(Homo sapiens)
BDBM237707
PNG
(US10052306, 253 | rac-(3aR,5r,6aS)-5-(3,4- difluor...)
Show SMILES OC(CN1C[C@H]2C[C@](O)(Cc3ccc(F)c(F)c3)C[C@H]2C1)c1ccc(O)cc1
Show InChI InChI=1S/C22H25F2NO3/c23-19-6-1-14(7-20(19)24)8-22(28)9-16-11-25(12-17(16)10-22)13-21(27)15-2-4-18(26)5-3-15/h1-7,16-17,21,26-28H,8-13H2/t16-,17+,21?,22-
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n/an/a 31.5n/an/an/an/an/an/a



CADENT THERAPEUTICS, INC.

US Patent


Assay Description
To each well of the plate, 10 μL test compound, control (MK801) or HHnoCa buffer was added to a final concentration of 10 μM with a final c...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor


(Homo sapiens)
BDBM237331
PNG
(US10052306, 177 | rac-6-(2-((3aR,5r,6aS)-5- benzyl...)
Show SMILES CO[C@]1(Cc2ccccc2)C[C@@H]2CN(CC(O)c3ccc(O)cn3)C[C@@H]2C1
Show InChI InChI=1S/C22H28N2O3/c1-27-22(9-16-5-3-2-4-6-16)10-17-13-24(14-18(17)11-22)15-21(26)20-8-7-19(25)12-23-20/h2-8,12,17-18,21,25-26H,9-11,13-15H2,1H3/t17-,18+,21?,22-
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n/an/a 31.6n/an/an/an/an/an/a



CADENT THERAPEUTICS, INC.

US Patent


Assay Description
To each well of the plate, 10 μL test compound, control (MK801) or HHnoCa buffer was added to a final concentration of 10 μM with a final c...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor


(Homo sapiens)
BDBM237710
PNG
((3aR,5R,6aS)-5-(4- fluorobenzyl)-2-((R)-2- hydroxy...)
Show SMILES O[C@H](CN1C[C@H]2C[C@](O)(Cc3ccc(F)cc3)C[C@H]2C1)c1ccc(O)cn1
Show InChI InChI=1S/C21H25FN2O3/c22-17-3-1-14(2-4-17)7-21(27)8-15-11-24(12-16(15)9-21)13-20(26)19-6-5-18(25)10-23-19/h1-6,10,15-16,20,25-27H,7-9,11-13H2/t15-,16+,20-,21-/m1/s1
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n/an/a 31.7n/an/an/an/an/an/a



CADENT THERAPEUTICS, INC.

US Patent


Assay Description
To each well of the plate, 10 μL test compound, control (MK801) or HHnoCa buffer was added to a final concentration of 10 μM with a final c...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor


(Homo sapiens)
BDBM237330
PNG
(US10052306, 176 | rac-4-(2-((3aR,5r,6aS)-5- benzyl...)
Show SMILES CO[C@]1(Cc2ccccc2)C[C@@H]2CN(CC(O)c3ccc(O)cc3)C[C@@H]2C1
Show InChI InChI=1S/C23H29NO3/c1-27-23(11-17-5-3-2-4-6-17)12-19-14-24(15-20(19)13-23)16-22(26)18-7-9-21(25)10-8-18/h2-10,19-20,22,25-26H,11-16H2,1H3/t19-,20+,22?,23-
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n/an/a 32.4n/an/an/an/an/an/a



CADENT THERAPEUTICS, INC.

US Patent


Assay Description
To each well of the plate, 10 μL test compound, control (MK801) or HHnoCa buffer was added to a final concentration of 10 μM with a final c...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor


(Homo sapiens)
BDBM237329
PNG
(US10052306, 175 | rac-4-(2-((3aR,5r,6aS)-5- benzyl...)
Show SMILES CO[C@]1(Cc2ccccc2)C[C@@H]2CN(CC(O)c3ccc(O)c(F)c3)C[C@@H]2C1
Show InChI InChI=1S/C23H28FNO3/c1-28-23(10-16-5-3-2-4-6-16)11-18-13-25(14-19(18)12-23)15-22(27)17-7-8-21(26)20(24)9-17/h2-9,18-19,22,26-27H,10-15H2,1H3/t18-,19+,22?,23-
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n/an/a 32.4n/an/an/an/an/an/a



CADENT THERAPEUTICS, INC.

US Patent


Assay Description
To each well of the plate, 10 μL test compound, control (MK801) or HHnoCa buffer was added to a final concentration of 10 μM with a final c...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor


(Homo sapiens)
BDBM237319
PNG
((3aR,5R,6aS)-5-benzyl-2- ((R)-2-hydroxy-2-(5- hydr...)
Show SMILES O[C@H](CN1C[C@H]2C[C@](O)(Cc3ccccc3)C[C@H]2C1)c1ccc(O)cn1
Show InChI InChI=1S/C21H26N2O3/c24-18-6-7-19(22-11-18)20(25)14-23-12-16-9-21(26,10-17(16)13-23)8-15-4-2-1-3-5-15/h1-7,11,16-17,20,24-26H,8-10,12-14H2/t16-,17+,20-,21-/m1/s1
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n/an/a 33.7n/an/an/an/an/an/a



CADENT THERAPEUTICS, INC.

US Patent


Assay Description
To each well of the plate, 10 μL test compound, control (MK801) or HHnoCa buffer was added to a final concentration of 10 μM with a final c...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor


(Homo sapiens)
BDBM237369
PNG
(US10052306, 185 | rac-(3aR,5r,6aS)-2-(2- hydroxy-2...)
Show SMILES Cc1ccccc1C[C@@]1(O)C[C@@H]2CN(CC(O)c3ccc(O)cc3)C[C@@H]2C1
Show InChI InChI=1S/C23H29NO3/c1-16-4-2-3-5-18(16)10-23(27)11-19-13-24(14-20(19)12-23)15-22(26)17-6-8-21(25)9-7-17/h2-9,19-20,22,25-27H,10-15H2,1H3/t19-,20+,22?,23-
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n/an/a 34.9n/an/an/an/an/an/a



CADENT THERAPEUTICS, INC.

US Patent


Assay Description
To each well of the plate, 10 μL test compound, control (MK801) or HHnoCa buffer was added to a final concentration of 10 μM with a final c...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor


(Homo sapiens)
BDBM237545
PNG
(2-[(3aR,5R,6aS)-5- hydroxy-5-{[4- (trifluoromethyl...)
Show SMILES Oc1ccc(nc1)C(=O)CN1C[C@H]2C[C@](O)(Cc3ccc(cc3)C(F)(F)F)C[C@H]2C1
Show InChI InChI=1S/C22H23F3N2O3/c23-22(24,25)17-3-1-14(2-4-17)7-21(30)8-15-11-27(12-16(15)9-21)13-20(29)19-6-5-18(28)10-26-19/h1-6,10,15-16,28,30H,7-9,11-13H2/t15-,16+,21-
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n/an/a 36n/an/an/an/an/an/a



CADENT THERAPEUTICS, INC.

US Patent


Assay Description
To each well of the plate, 10 μL test compound, control (MK801) or HHnoCa buffer was added to a final concentration of 10 μM with a final c...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor


(Homo sapiens)
BDBM237383
PNG
(US10052306, 199 | rac-6-{2-[(3aR,5R,6aS)- 5-hydrox...)
Show SMILES COc1ccc(C[C@@]2(O)C[C@@H]3CN(CC(O)c4ccc(O)cn4)C[C@@H]3C2)cc1
Show InChI InChI=1S/C22H28N2O4/c1-28-19-5-2-15(3-6-19)8-22(27)9-16-12-24(13-17(16)10-22)14-21(26)20-7-4-18(25)11-23-20/h2-7,11,16-17,21,25-27H,8-10,12-14H2,1H3/t16-,17+,21?,22-
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n/an/a 36.3n/an/an/an/an/an/a



CADENT THERAPEUTICS, INC.

US Patent


Assay Description
To each well of the plate, 10 μL test compound, control (MK801) or HHnoCa buffer was added to a final concentration of 10 μM with a final c...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor


(Homo sapiens)
BDBM238877
PNG
(US10052306, 316 | rac-4-(2-((3aR,5s,6aS)- 5-benzyl...)
Show SMILES OC(CN1C[C@H]2C[C@@](F)(Cc3ccccc3)C[C@H]2C1)c1ccc(O)c(F)c1
Show InChI InChI=1S/C22H25F2NO2/c23-19-8-16(6-7-20(19)26)21(27)14-25-12-17-10-22(24,11-18(17)13-25)9-15-4-2-1-3-5-15/h1-8,17-18,21,26-27H,9-14H2/t17-,18+,21?,22+
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n/an/a 36.4n/an/an/an/an/an/a



CADENT THERAPEUTICS, INC.

US Patent


Assay Description
To each well of the plate, 10 μL test compound, control (MK801) or HHnoCa buffer was added to a final concentration of 10 μM with a final c...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor


(Homo sapiens)
BDBM237318
PNG
((3aR,5S,6aS)-5-benzyl-2- ((S)-2-hydroxy-2-(5- hydr...)
Show SMILES O[C@@H](CN1C[C@H]2C[C@](O)(Cc3ccccc3)C[C@H]2C1)c1ccc(O)cn1
Show InChI InChI=1S/C21H26N2O3/c24-18-6-7-19(22-11-18)20(25)14-23-12-16-9-21(26,10-17(16)13-23)8-15-4-2-1-3-5-15/h1-7,11,16-17,20,24-26H,8-10,12-14H2/t16-,17+,20-,21-/m0/s1
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n/an/a 38.1n/an/an/an/an/an/a



CADENT THERAPEUTICS, INC.

US Patent


Assay Description
To each well of the plate, 10 μL test compound, control (MK801) or HHnoCa buffer was added to a final concentration of 10 μM with a final c...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor


(Homo sapiens)
BDBM238864
PNG
(2-[(3aR,5S,6aS)-5- benzyl- octahydrocyclopenta[c] ...)
Show SMILES Oc1ccc(cc1)C(=O)CN1C[C@@H]2C[C@H](Cc3ccccc3)C[C@@H]2C1
Show InChI InChI=1S/C22H25NO2/c24-21-8-6-18(7-9-21)22(25)15-23-13-19-11-17(12-20(19)14-23)10-16-4-2-1-3-5-16/h1-9,17,19-20,24H,10-15H2/t17-,19-,20+
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n/an/a 38.8n/an/an/an/an/an/a



CADENT THERAPEUTICS, INC.

US Patent


Assay Description
To each well of the plate, 10 μL test compound, control (MK801) or HHnoCa buffer was added to a final concentration of 10 μM with a final c...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor


(Homo sapiens)
BDBM235387
PNG
(US10052306, 153 | rac-6-(2-((3aR,5r,6aS)-5- benzyl...)
Show SMILES OC(CN1C[C@H]2C[C@](O)(Cc3ccccc3)C[C@H]2C1)c1ccc2NC(=O)CCc2c1
Show InChI InChI=1S/C25H30N2O3/c28-23(19-6-8-22-18(10-19)7-9-24(29)26-22)16-27-14-20-12-25(30,13-21(20)15-27)11-17-4-2-1-3-5-17/h1-6,8,10,20-21,23,28,30H,7,9,11-16H2,(H,26,29)/t20-,21+,23?,25-
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n/an/a 40.2n/an/an/an/an/an/a



CADENT THERAPEUTICS, INC.

US Patent


Assay Description
To each well of the plate, 10 μL test compound, control (MK801) or HHnoCa buffer was added to a final concentration of 10 μM with a final c...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor


(Homo sapiens)
BDBM237682
PNG
(US10052306, 228 | rac-5-(2-fluorobenzyl)-2- (2-hyd...)
Show SMILES OC(CN1C[C@H]2C[C@](O)(Cc3ccccc3F)C[C@H]2C1)c1ccc(O)cn1
Show InChI InChI=1S/C21H25FN2O3/c22-18-4-2-1-3-14(18)7-21(27)8-15-11-24(12-16(15)9-21)13-20(26)19-6-5-17(25)10-23-19/h1-6,10,15-16,20,25-27H,7-9,11-13H2/t15-,16+,20?,21-
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n/an/a 40.9n/an/an/an/an/an/a



CADENT THERAPEUTICS, INC.

US Patent


Assay Description
To each well of the plate, 10 μL test compound, control (MK801) or HHnoCa buffer was added to a final concentration of 10 μM with a final c...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor


(Homo sapiens)
BDBM238868
PNG
(2-[(3aR,5S,6aS)-5- benzyl- octahydrocyclopenta[c] ...)
Show SMILES Oc1ccc(cc1F)C(=O)CN1C[C@@H]2C[C@H](Cc3ccccc3)C[C@@H]2C1
Show InChI InChI=1S/C22H24FNO2/c23-20-11-17(6-7-21(20)25)22(26)14-24-12-18-9-16(10-19(18)13-24)8-15-4-2-1-3-5-15/h1-7,11,16,18-19,25H,8-10,12-14H2/t16-,18-,19+
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n/an/a 41.2n/an/an/an/an/an/a



CADENT THERAPEUTICS, INC.

US Patent


Assay Description
To each well of the plate, 10 μL test compound, control (MK801) or HHnoCa buffer was added to a final concentration of 10 μM with a final c...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor


(Homo sapiens)
BDBM237366
PNG
(US10052306, 182 | rac-(3aR,5R,6aS)-2-[2- hydroxy-2...)
Show SMILES Cc1ccc(C[C@@]2(O)C[C@@H]3CN(CC(O)c4ccc(O)cc4)C[C@@H]3C2)cc1
Show InChI InChI=1S/C23H29NO3/c1-16-2-4-17(5-3-16)10-23(27)11-19-13-24(14-20(19)12-23)15-22(26)18-6-8-21(25)9-7-18/h2-9,19-20,22,25-27H,10-15H2,1H3/t19-,20+,22?,23-
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n/an/a 41.5n/an/an/an/an/an/a



CADENT THERAPEUTICS, INC.

US Patent


Assay Description
To each well of the plate, 10 μL test compound, control (MK801) or HHnoCa buffer was added to a final concentration of 10 μM with a final c...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor


(Homo sapiens)
BDBM237708
PNG
(US10052306, 254 | rac-(3aR,5r,6aS)-5-(4- fluoro-2-...)
Show SMILES Cc1cc(F)ccc1C[C@@]1(O)C[C@@H]2CN(CC(O)c3ccc(O)cc3)C[C@@H]2C1
Show InChI InChI=1S/C23H28FNO3/c1-15-8-20(24)5-2-17(15)9-23(28)10-18-12-25(13-19(18)11-23)14-22(27)16-3-6-21(26)7-4-16/h2-8,18-19,22,26-28H,9-14H2,1H3/t18-,19+,22?,23-
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n/an/a 42.5n/an/an/an/an/an/a



CADENT THERAPEUTICS, INC.

US Patent


Assay Description
To each well of the plate, 10 μL test compound, control (MK801) or HHnoCa buffer was added to a final concentration of 10 μM with a final c...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor


(Homo sapiens)
BDBM238288
PNG
(US10052306, 280 | rac-(3aR,5R,6aS)-5- benzyl-2-[2-...)
Show SMILES CC(O)(CN1CC2CC(O)(Cc3ccccc3)CC2C1)c1ccc(O)cc1
Show InChI InChI=1S/C23H29NO3/c1-22(26,20-7-9-21(25)10-8-20)16-24-14-18-12-23(27,13-19(18)15-24)11-17-5-3-2-4-6-17/h2-10,18-19,25-27H,11-16H2,1H3
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n/an/a 43n/an/an/an/an/an/a



CADENT THERAPEUTICS, INC.

US Patent


Assay Description
To each well of the plate, 10 μL test compound, control (MK801) or HHnoCa buffer was added to a final concentration of 10 μM with a final c...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor


(Homo sapiens)
BDBM235338
PNG
(2-((3aR,5r,6aS)-5-(4- fluorobenzyl)-5- hydroxyhexa...)
Show SMILES Oc1ccc(cc1)C(=O)CN1C[C@H]2C[C@](O)(Cc3ccc(F)cc3)C[C@H]2C1
Show InChI InChI=1S/C22H24FNO3/c23-19-5-1-15(2-6-19)9-22(27)10-17-12-24(13-18(17)11-22)14-21(26)16-3-7-20(25)8-4-16/h1-8,17-18,25,27H,9-14H2/t17-,18+,22-
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n/an/a 43.2n/an/an/an/an/an/a



CADENT THERAPEUTICS, INC.

US Patent


Assay Description
To each well of the plate, 10 μL test compound, control (MK801) or HHnoCa buffer was added to a final concentration of 10 μM with a final c...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor


(Homo sapiens)
BDBM237368
PNG
(2-[(3aR,5R,6aS)-5- hydroxy-5-[(4- methoxyphenyl)me...)
Show SMILES COc1ccc(C[C@@]2(O)C[C@@H]3CN(CC(=O)c4ccc(O)cc4)C[C@@H]3C2)cc1
Show InChI InChI=1S/C23H27NO4/c1-28-21-8-2-16(3-9-21)10-23(27)11-18-13-24(14-19(18)12-23)15-22(26)17-4-6-20(25)7-5-17/h2-9,18-19,25,27H,10-15H2,1H3/t18-,19+,23-
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n/an/a 43.3n/an/an/an/an/an/a



CADENT THERAPEUTICS, INC.

US Patent


Assay Description
To each well of the plate, 10 μL test compound, control (MK801) or HHnoCa buffer was added to a final concentration of 10 μM with a final c...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor


(Homo sapiens)
BDBM235334
PNG
(2-((3aR,5r,6aS)-5-benzyl- 5- hydroxyhexahydrocyclo...)
Show SMILES Oc1ccc(cc1)C(=O)CN1C[C@H]2C[C@](O)(Cc3ccccc3)C[C@H]2C1
Show InChI InChI=1S/C22H25NO3/c24-20-8-6-17(7-9-20)21(25)15-23-13-18-11-22(26,12-19(18)14-23)10-16-4-2-1-3-5-16/h1-9,18-19,24,26H,10-15H2/t18-,19+,22-
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n/an/a 44.1n/an/an/an/an/an/a



CADENT THERAPEUTICS, INC.

US Patent


Assay Description
To each well of the plate, 10 μL test compound, control (MK801) or HHnoCa buffer was added to a final concentration of 10 μM with a final c...


Citation and Details
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%