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Patent code US10053462

Compile Data Set for Download or QSAR
Found 195 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
P2X purinoceptor 7


(Mus musculus)
BDBM174777
PNG
(US10053462, 8 | US9102686, 8 | US9540388, 8)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CCC[C@@H]2c2nnc(-c4cscn4)n2C3)c1Cl
Show InChI InChI=1S/C19H15ClF3N5OS/c20-15-11(4-2-5-12(15)19(21,22)23)18(29)28-10-3-1-6-14(28)17-26-25-16(27(17)7-10)13-8-30-9-24-13/h2,4-5,8-10,14H,1,3,6-7H2/t10-,14+/m0/s1
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1.30n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


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More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM203334
PNG
((6r,10s)-11-[(2,3-dichloro-4-fluorophenyl)carbonyl...)
Show SMILES Fc1ccc(C(=O)N2[C@H]3CCC[C@@H]2c2nnc(-c4ccccn4)n2C3)c(Cl)c1Cl
Show InChI InChI=1S/C20H16Cl2FN5O/c21-16-12(7-8-13(23)17(16)22)20(29)28-11-4-3-6-15(28)19-26-25-18(27(19)10-11)14-5-1-2-9-24-14/h1-2,5,7-9,11,15H,3-4,6,10H2/t11-,15+/m0/s1
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2.20n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM203315
PNG
((6r,10s)-11-{[2-chloro-3-(trifluoromethyl)phenyl]c...)
Show SMILES Cc1ccnc(c1)-c1nnc2[C@H]3CCC[C@@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C22H19ClF3N5O/c1-12-8-9-27-16(10-12)19-28-29-20-17-7-2-4-13(11-30(19)20)31(17)21(32)14-5-3-6-15(18(14)23)22(24,25)26/h3,5-6,8-10,13,17H,2,4,7,11H2,1H3/t13-,17+/m0/s1
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3.10n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM203332
PNG
((6r,10s)-11-{[2-methyl-3-(trifluoromethyl)phenyl]c...)
Show SMILES Cc1c(cccc1C(F)(F)F)C(=O)N1[C@H]2CCC[C@@H]1c1nnc(-c3ccccn3)n1C2
Show InChI InChI=1S/C22H20F3N5O/c1-13-15(7-5-8-16(13)22(23,24)25)21(31)30-14-6-4-10-18(30)20-28-27-19(29(20)12-14)17-9-2-3-11-26-17/h2-3,5,7-9,11,14,18H,4,6,10,12H2,1H3/t14-,18+/m0/s1
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3.20n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM203331
PNG
((6r,10s)-11-{[2-chloro-4-fluoro-3-(trifluoromethyl...)
Show SMILES Fc1ccc(C(=O)N2[C@H]3CCC[C@@H]2c2nnc(-c4ccccn4)n2C3)c(Cl)c1C(F)(F)F
Show InChI InChI=1S/C21H16ClF4N5O/c22-17-12(7-8-13(23)16(17)21(24,25)26)20(32)31-11-4-3-6-15(31)19-29-28-18(30(19)10-11)14-5-1-2-9-27-14/h1-2,5,7-9,11,15H,3-4,6,10H2/t11-,15+/m0/s1
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3.20n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM174802
PNG
(US10053462, 33 | US9102686, 33 | US9540388, 32)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CCC[C@@H]2c2nnc(-c4ccccn4)n2C3)c1Cl
Show InChI InChI=1S/C21H17ClF3N5O/c22-17-13(6-4-7-14(17)21(23,24)25)20(31)30-12-5-3-9-16(30)19-28-27-18(29(19)11-12)15-8-1-2-10-26-15/h1-2,4,6-8,10,12,16H,3,5,9,11H2/t12-,16+/m0/s1
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3.20n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM174781
PNG
(US10053462, 12 | US9102686, 12 | US9540388, 12)
Show SMILES Fc1ccc(nc1)-c1nnc2[C@@H]3CCC[C@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C21H16ClF4N5O/c22-17-13(4-2-5-14(17)21(24,25)26)20(32)31-12-3-1-6-16(31)19-29-28-18(30(19)10-12)15-8-7-11(23)9-27-15/h2,4-5,7-9,12,16H,1,3,6,10H2/t12-,16+/m1/s1
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3.40n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM203333
PNG
((6r,10s)-11-[(2,4-dichloro-3-fluorophenyl)carbonyl...)
Show SMILES Fc1c(Cl)ccc(C(=O)N2[C@H]3CCC[C@@H]2c2nnc(-c4ccccn4)n2C3)c1Cl
Show InChI InChI=1S/C20H16Cl2FN5O/c21-13-8-7-12(16(22)17(13)23)20(29)28-11-4-3-6-15(28)19-26-25-18(27(19)10-11)14-5-1-2-9-24-14/h1-2,5,7-9,11,15H,3-4,6,10H2/t11-,15+/m0/s1
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3.90n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM174795
PNG
(US10053462, 26 | US9102686, 26 | US9540388, 26)
Show SMILES COc1ccnc(c1)-c1nnc2[C@H]3CCC[C@@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C22H19ClF3N5O2/c1-33-13-8-9-27-16(10-13)19-28-29-20-17-7-2-4-12(11-30(19)20)31(17)21(32)14-5-3-6-15(18(14)23)22(24,25)26/h3,5-6,8-10,12,17H,2,4,7,11H2,1H3/t12-,17+/m0/s1
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4n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

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Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM174818
PNG
(US10053462, 49 | US9102686, 49 | US9540388, 49)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4cscn4)n2C3)c1Cl
Show InChI InChI=1S/C18H13ClF3N5OS/c19-14-10(2-1-3-11(14)18(20,21)22)17(28)27-9-4-5-13(27)16-25-24-15(26(16)6-9)12-7-29-8-23-12/h1-3,7-9,13H,4-6H2/t9-,13+/m0/s1
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4n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174830
PNG
(US10053462, 61 | US9102686, 61 | US9540388, 61)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4cccs4)n2C3)c1Cl
Show InChI InChI=1S/C19H14ClF3N4OS/c20-15-11(3-1-4-12(15)19(21,22)23)18(28)27-10-6-7-13(27)16-24-25-17(26(16)9-10)14-5-2-8-29-14/h1-5,8,10,13H,6-7,9H2/t10-,13+/m0/s1
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4n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM174772
PNG
(US10053462, 3 | US9102686, 3 | US9540388, 3)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@@H]3CCC[C@H]2c2nnc(-c4ncccn4)n2C3)c1Cl
Show InChI InChI=1S/C20H16ClF3N6O/c21-15-12(5-2-6-13(15)20(22,23)24)19(31)30-11-4-1-7-14(30)17-27-28-18(29(17)10-11)16-25-8-3-9-26-16/h2-3,5-6,8-9,11,14H,1,4,7,10H2/t11-,14+/m1/s1
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4n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM203314
PNG
((6r,10s)-11-{[2-chloro-3-(trifluoromethyl)phenyl]c...)
Show SMILES Cc1nc(ccc1F)-c1nnc2[C@H]3CCC[C@@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C22H18ClF4N5O/c1-11-15(24)8-9-16(28-11)19-29-30-20-17-7-2-4-12(10-31(19)20)32(17)21(33)13-5-3-6-14(18(13)23)22(25,26)27/h3,5-6,8-9,12,17H,2,4,7,10H2,1H3/t12-,17+/m0/s1
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4.90n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM203324
PNG
((6r,10s)-11-{[3-chloro-2-(trifluoromethyl)pyridin-...)
Show SMILES FC(F)(F)c1nccc(C(=O)N2[C@H]3CCC[C@@H]2c2nnc(-c4ccccn4)n2C3)c1Cl
Show InChI InChI=1S/C20H16ClF3N6O/c21-15-12(7-9-26-16(15)20(22,23)24)19(31)30-11-4-3-6-14(30)18-28-27-17(29(18)10-11)13-5-1-2-8-25-13/h1-2,5,7-9,11,14H,3-4,6,10H2/t11-,14+/m0/s1
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5n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM174792
PNG
(US10053462, 23 | US9102686, 23 | US9540388, 23)
Show SMILES Cc1cccc(n1)-c1nnc2[C@H]3CCC[C@@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C22H19ClF3N5O/c1-12-5-2-9-16(27-12)19-28-29-20-17-10-3-6-13(11-30(19)20)31(17)21(32)14-7-4-8-15(18(14)23)22(24,25)26/h2,4-5,7-9,13,17H,3,6,10-11H2,1H3/t13-,17+/m0/s1
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5n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM203334
PNG
((6r,10s)-11-[(2,3-dichloro-4-fluorophenyl)carbonyl...)
Show SMILES Fc1ccc(C(=O)N2[C@H]3CCC[C@@H]2c2nnc(-c4ccccn4)n2C3)c(Cl)c1Cl
Show InChI InChI=1S/C20H16Cl2FN5O/c21-16-12(7-8-13(23)17(16)22)20(29)28-11-4-3-6-15(28)19-26-25-18(27(19)10-11)14-5-1-2-9-24-14/h1-2,5,7-9,11,15H,3-4,6,10H2/t11-,15+/m0/s1
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5.30n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM203318
PNG
((6r,10s)-11-{[2-chloro-3-(trifluoromethyl)phenyl]c...)
Show SMILES FC(F)(F)c1ccnc(c1)-c1nnc2[C@H]3CCC[C@@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C22H16ClF6N5O/c23-17-13(4-2-5-14(17)22(27,28)29)20(35)34-12-3-1-6-16(34)19-32-31-18(33(19)10-12)15-9-11(7-8-30-15)21(24,25)26/h2,4-5,7-9,12,16H,1,3,6,10H2/t12-,16+/m0/s1
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5.80n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM203333
PNG
((6r,10s)-11-[(2,4-dichloro-3-fluorophenyl)carbonyl...)
Show SMILES Fc1c(Cl)ccc(C(=O)N2[C@H]3CCC[C@@H]2c2nnc(-c4ccccn4)n2C3)c1Cl
Show InChI InChI=1S/C20H16Cl2FN5O/c21-13-8-7-12(16(22)17(13)23)20(29)28-11-4-3-6-15(28)19-26-25-18(27(19)10-11)14-5-1-2-9-24-14/h1-2,5,7-9,11,15H,3-4,6,10H2/t11-,15+/m0/s1
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5.80n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM203323
PNG
((6r,10s)-11-{[3-fluoro-2-(trifluoromethyl)pyridin-...)
Show SMILES Fc1c(ccnc1C(F)(F)F)C(=O)N1[C@H]2CCC[C@@H]1c1nnc(-c3ccccn3)n1C2
Show InChI InChI=1S/C20H16F4N6O/c21-15-12(7-9-26-16(15)20(22,23)24)19(31)30-11-4-3-6-14(30)18-28-27-17(29(18)10-11)13-5-1-2-8-25-13/h1-2,5,7-9,11,14H,3-4,6,10H2/t11-,14+/m0/s1
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6.20n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM174821
PNG
(US10053462, 52 | US9102686, 52 | US9540388, 52)
Show SMILES Fc1ccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4cscn4)n2C3)c(Cl)c1C(F)(F)F
Show InChI InChI=1S/C18H12ClF4N5OS/c19-14-9(2-3-10(20)13(14)18(21,22)23)17(29)28-8-1-4-12(28)16-26-25-15(27(16)5-8)11-6-30-7-24-11/h2-3,6-8,12H,1,4-5H2/t8-,12+/m0/s1
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6.30n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM174816
PNG
(US10053462, 47 | US9102686, 47 | US9540388, 47)
Show SMILES Fc1ccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4cnccn4)n2C3)c(Cl)c1Cl
Show InChI InChI=1S/C18H13Cl2FN6O/c19-14-10(2-3-11(21)15(14)20)18(28)27-9-1-4-13(27)17-25-24-16(26(17)8-9)12-7-22-5-6-23-12/h2-3,5-7,9,13H,1,4,8H2/t9-,13+/m0/s1
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6.30n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174831
PNG
(US10053462, 62 | US9102686, 62 | US9540388, 62)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4ccc[nH]4)n2C3)c1Cl
Show InChI InChI=1S/C19H15ClF3N5O/c20-15-11(3-1-4-12(15)19(21,22)23)18(29)28-10-6-7-14(28)17-26-25-16(27(17)9-10)13-5-2-8-24-13/h1-5,8,10,14,24H,6-7,9H2/t10-,14+/m0/s1
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6.30n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM174815
PNG
(US10053462, 46 | US9102686, 46 | US9540388, 46)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4ncccn4)n2C3)c1Cl
Show InChI InChI=1S/C19H14ClF3N6O/c20-14-11(3-1-4-12(14)19(21,22)23)18(30)29-10-5-6-13(29)16-26-27-17(28(16)9-10)15-24-7-2-8-25-15/h1-4,7-8,10,13H,5-6,9H2/t10-,13+/m0/s1
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6.30n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM174823
PNG
(US10053462, 54 | US9102686, 54 | US9540388, 54)
Show SMILES Fc1c(Cl)ccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4cscn4)n2C3)c1Cl
Show InChI InChI=1S/C17H12Cl2FN5OS/c18-10-3-2-9(13(19)14(10)20)17(26)25-8-1-4-12(25)16-23-22-15(24(16)5-8)11-6-27-7-21-11/h2-3,6-8,12H,1,4-5H2/t8-,12+/m0/s1
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7.90n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM174811
PNG
(US10053462, 42 | US9102686, 42 | US9540388, 42)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4cnccn4)n2C3)c1Cl
Show InChI InChI=1S/C19H14ClF3N6O/c20-15-11(2-1-3-12(15)19(21,22)23)18(30)29-10-4-5-14(29)17-27-26-16(28(17)9-10)13-8-24-6-7-25-13/h1-3,6-8,10,14H,4-5,9H2/t10-,14+/m0/s1
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7.90n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM174822
PNG
(US10053462, 53 | US9102686, 53 | US9540388, 53)
Show SMILES Cc1c(cccc1C(F)(F)F)C(=O)N1[C@H]2CC[C@@H]1c1nnc(-c3cscn3)n1C2
Show InChI InChI=1S/C19H16F3N5OS/c1-10-12(3-2-4-13(10)19(20,21)22)18(28)27-11-5-6-15(27)17-25-24-16(26(17)7-11)14-8-29-9-23-14/h2-4,8-9,11,15H,5-7H2,1H3/t11-,15+/m0/s1
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7.90n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM174820
PNG
(US10053462, 51 | US9102686, 51 | US9540388, 51)
Show SMILES Cc1cc([nH]n1)-c1nnc2[C@H]3CC[C@@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C19H16ClF3N6O/c1-9-7-13(25-24-9)16-26-27-17-14-6-5-10(8-28(16)17)29(14)18(30)11-3-2-4-12(15(11)20)19(21,22)23/h2-4,7,10,14H,5-6,8H2,1H3,(H,24,25)/t10-,14+/m0/s1
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7.90n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM174810
PNG
(US10053462, 41 | US9102686, 41 | US9540388, 41)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4ccccn4)n2C3)c1Cl
Show InChI InChI=1S/C20H15ClF3N5O/c21-16-12(4-3-5-13(16)20(22,23)24)19(30)29-11-7-8-15(29)18-27-26-17(28(18)10-11)14-6-1-2-9-25-14/h1-6,9,11,15H,7-8,10H2/t11-,15+/m0/s1
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7.90n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM203323
PNG
((6r,10s)-11-{[3-fluoro-2-(trifluoromethyl)pyridin-...)
Show SMILES Fc1c(ccnc1C(F)(F)F)C(=O)N1[C@H]2CCC[C@@H]1c1nnc(-c3ccccn3)n1C2
Show InChI InChI=1S/C20H16F4N6O/c21-15-12(7-9-26-16(15)20(22,23)24)19(31)30-11-4-3-6-14(30)18-28-27-17(29(18)10-11)13-5-1-2-8-25-13/h1-2,5,7-9,11,14H,3-4,6,10H2/t11-,14+/m0/s1
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9.80n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174827
PNG
(US10053462, 58 | US9102686, 58 | US9540388, 58)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4ccsc4)n2C3)c1Cl
Show InChI InChI=1S/C19H14ClF3N4OS/c20-15-12(2-1-3-13(15)19(21,22)23)18(28)27-11-4-5-14(27)17-25-24-16(26(17)8-11)10-6-7-29-9-10/h1-3,6-7,9,11,14H,4-5,8H2/t11-,14+/m0/s1
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10n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174777
PNG
(US10053462, 8 | US9102686, 8 | US9540388, 8)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CCC[C@@H]2c2nnc(-c4cscn4)n2C3)c1Cl
Show InChI InChI=1S/C19H15ClF3N5OS/c20-15-11(4-2-5-12(15)19(21,22)23)18(29)28-10-3-1-6-14(28)17-26-25-16(27(17)7-10)13-8-30-9-24-13/h2,4-5,8-10,14H,1,3,6-7H2/t10-,14+/m0/s1
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10n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174816
PNG
(US10053462, 47 | US9102686, 47 | US9540388, 47)
Show SMILES Fc1ccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4cnccn4)n2C3)c(Cl)c1Cl
Show InChI InChI=1S/C18H13Cl2FN6O/c19-14-10(2-3-11(21)15(14)20)18(28)27-9-1-4-13(27)17-25-24-16(26(17)8-9)12-7-22-5-6-23-12/h2-3,5-7,9,13H,1,4,8H2/t9-,13+/m0/s1
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10n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM174819
PNG
(US10053462, 50 | US9102686, 50 | US9540388, 50)
Show SMILES Fc1cnc(nc1)-c1nnc2[C@H]3CC[C@@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C19H13ClF4N6O/c20-14-11(2-1-3-12(14)19(22,23)24)18(31)30-10-4-5-13(30)16-27-28-17(29(16)8-10)15-25-6-9(21)7-26-15/h1-3,6-7,10,13H,4-5,8H2/t10-,13+/m0/s1
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10n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174802
PNG
(US10053462, 33 | US9102686, 33 | US9540388, 32)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CCC[C@@H]2c2nnc(-c4ccccn4)n2C3)c1Cl
Show InChI InChI=1S/C21H17ClF3N5O/c22-17-13(6-4-7-14(17)21(23,24)25)20(31)30-12-5-3-9-16(30)19-28-27-18(29(19)11-12)15-8-1-2-10-26-15/h1-2,4,6-8,10,12,16H,3,5,9,11H2/t12-,16+/m0/s1
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10.5n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM203331
PNG
((6r,10s)-11-{[2-chloro-4-fluoro-3-(trifluoromethyl...)
Show SMILES Fc1ccc(C(=O)N2[C@H]3CCC[C@@H]2c2nnc(-c4ccccn4)n2C3)c(Cl)c1C(F)(F)F
Show InChI InChI=1S/C21H16ClF4N5O/c22-17-12(7-8-13(23)16(17)21(24,25)26)20(32)31-11-4-3-6-15(31)19-29-28-18(30(19)10-11)14-5-1-2-9-27-14/h1-2,5,7-9,11,15H,3-4,6,10H2/t11-,15+/m0/s1
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10.7n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174805
PNG
(US10053462, 36 | US9102686, 36 | US9540388, 36)
Show SMILES FC(F)(F)c1nccc(C(=O)N2[C@@H]3CCC[C@H]2c2nnc(-c4cccs4)n2C3)c1Cl
Show InChI InChI=1S/C19H15ClF3N5OS/c20-14-11(6-7-24-15(14)19(21,22)23)18(29)28-10-3-1-4-12(28)16-25-26-17(27(16)9-10)13-5-2-8-30-13/h2,5-8,10,12H,1,3-4,9H2/t10-,12+/m1/s1
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10.7n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM203332
PNG
((6r,10s)-11-{[2-methyl-3-(trifluoromethyl)phenyl]c...)
Show SMILES Cc1c(cccc1C(F)(F)F)C(=O)N1[C@H]2CCC[C@@H]1c1nnc(-c3ccccn3)n1C2
Show InChI InChI=1S/C22H20F3N5O/c1-13-15(7-5-8-16(13)22(23,24)25)21(31)30-14-6-4-10-18(30)20-28-27-19(29(20)12-14)17-9-2-3-11-26-17/h2-3,5,7-9,11,14,18H,4,6,10,12H2,1H3/t14-,18+/m0/s1
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11.5n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174781
PNG
(US10053462, 12 | US9102686, 12 | US9540388, 12)
Show SMILES Fc1ccc(nc1)-c1nnc2[C@@H]3CCC[C@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C21H16ClF4N5O/c22-17-13(4-2-5-14(17)21(24,25)26)20(32)31-12-3-1-6-16(31)19-29-28-18(30(19)10-12)15-8-7-11(23)9-27-15/h2,4-5,7-9,12,16H,1,3,6,10H2/t12-,16+/m1/s1
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12.6n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174776
PNG
(US10053462, 7 | US9102686, 7 | US9540388, 7)
Show SMILES FC(F)(F)c1cccc(C(=O)N2C3CCCC2c2nnc(-c4cscn4)n2C3)c1Cl
Show InChI InChI=1S/C19H15ClF3N5OS/c20-15-11(4-2-5-12(15)19(21,22)23)18(29)28-10-3-1-6-14(28)17-26-25-16(27(17)7-10)13-8-30-9-24-13/h2,4-5,8-10,14H,1,3,6-7H2
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12.6n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174774
PNG
(US10053462, 5 | US9102686, 5 | US9540388, 5)
Show SMILES Fc1ccc(cc1)-c1nnc2[C@H]3CCC[C@@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C22H17ClF4N4O/c23-18-15(4-2-5-16(18)22(25,26)27)21(32)31-14-3-1-6-17(31)20-29-28-19(30(20)11-14)12-7-9-13(24)10-8-12/h2,4-5,7-10,14,17H,1,3,6,11H2/t14-,17+/m0/s1
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12.6n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174822
PNG
(US10053462, 53 | US9102686, 53 | US9540388, 53)
Show SMILES Cc1c(cccc1C(F)(F)F)C(=O)N1[C@H]2CC[C@@H]1c1nnc(-c3cscn3)n1C2
Show InChI InChI=1S/C19H16F3N5OS/c1-10-12(3-2-4-13(10)19(20,21)22)18(28)27-11-5-6-15(27)17-25-24-16(26(17)7-11)14-8-29-9-23-14/h2-4,8-9,11,15H,5-7H2,1H3/t11-,15+/m0/s1
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12.6n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM174813
PNG
(US10053462, 44 | US9102686, 44 | US9540388, 44)
Show SMILES Cc1c(cccc1C(F)(F)F)C(=O)N1[C@H]2CC[C@@H]1c1nnc(-c3ccccn3)n1C2
Show InChI InChI=1S/C21H18F3N5O/c1-12-14(5-4-6-15(12)21(22,23)24)20(30)29-13-8-9-17(29)19-27-26-18(28(19)11-13)16-7-2-3-10-25-16/h2-7,10,13,17H,8-9,11H2,1H3/t13-,17+/m0/s1
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12.6n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174813
PNG
(US10053462, 44 | US9102686, 44 | US9540388, 44)
Show SMILES Cc1c(cccc1C(F)(F)F)C(=O)N1[C@H]2CC[C@@H]1c1nnc(-c3ccccn3)n1C2
Show InChI InChI=1S/C21H18F3N5O/c1-12-14(5-4-6-15(12)21(22,23)24)20(30)29-13-8-9-17(29)19-27-26-18(28(19)11-13)16-7-2-3-10-25-16/h2-7,10,13,17H,8-9,11H2,1H3/t13-,17+/m0/s1
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12.6n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174810
PNG
(US10053462, 41 | US9102686, 41 | US9540388, 41)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4ccccn4)n2C3)c1Cl
Show InChI InChI=1S/C20H15ClF3N5O/c21-16-12(4-3-5-13(16)20(22,23)24)19(30)29-11-7-8-15(29)18-27-26-17(28(18)10-11)14-6-1-2-9-25-14/h1-6,9,11,15H,7-8,10H2/t11-,15+/m0/s1
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12.6n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174811
PNG
(US10053462, 42 | US9102686, 42 | US9540388, 42)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4cnccn4)n2C3)c1Cl
Show InChI InChI=1S/C19H14ClF3N6O/c20-15-11(2-1-3-12(15)19(21,22)23)18(30)29-10-4-5-14(29)17-27-26-16(28(17)9-10)13-8-24-6-7-25-13/h1-3,6-8,10,14H,4-5,9H2/t10-,14+/m0/s1
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12.6n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174814
PNG
(US10053462, 45 | US9102686, 45 | US9540388, 45)
Show SMILES Fc1ccc(nc1)-c1nnc2[C@H]3CC[C@@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C20H14ClF4N5O/c21-16-12(2-1-3-13(16)20(23,24)25)19(31)30-11-5-7-15(30)18-28-27-17(29(18)9-11)14-6-4-10(22)8-26-14/h1-4,6,8,11,15H,5,7,9H2/t11-,15+/m0/s1
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12.6n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174812
PNG
(US10053462, 43 | US9102686, 43 | US9540388, 43)
Show SMILES Fc1ccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4ccccn4)n2C3)c(Cl)c1C(F)(F)F
Show InChI InChI=1S/C20H14ClF4N5O/c21-16-11(5-6-12(22)15(16)20(23,24)25)19(31)30-10-4-7-14(30)18-28-27-17(29(18)9-10)13-3-1-2-8-26-13/h1-3,5-6,8,10,14H,4,7,9H2/t10-,14+/m0/s1
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12.9n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM174812
PNG
(US10053462, 43 | US9102686, 43 | US9540388, 43)
Show SMILES Fc1ccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4ccccn4)n2C3)c(Cl)c1C(F)(F)F
Show InChI InChI=1S/C20H14ClF4N5O/c21-16-11(5-6-12(22)15(16)20(23,24)25)19(31)30-10-4-7-14(30)18-28-27-17(29(18)9-10)13-3-1-2-8-26-13/h1-3,5-6,8,10,14H,4,7,9H2/t10-,14+/m0/s1
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13.8n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174787
PNG
(US10053462, 18 | US9102686, 18 | US9540388, 18)
Show SMILES Fc1cnc(nc1)-c1nnc2[C@@H]3CCC[C@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C20H15ClF4N6O/c21-15-12(4-2-5-13(15)20(23,24)25)19(32)31-11-3-1-6-14(31)17-28-29-18(30(17)9-11)16-26-7-10(22)8-27-16/h2,4-5,7-8,11,14H,1,3,6,9H2/t11-,14+/m1/s1
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13.8n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM203315
PNG
((6r,10s)-11-{[2-chloro-3-(trifluoromethyl)phenyl]c...)
Show SMILES Cc1ccnc(c1)-c1nnc2[C@H]3CCC[C@@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C22H19ClF3N5O/c1-12-8-9-27-16(10-12)19-28-29-20-17-7-2-4-13(11-30(19)20)31(17)21(32)14-5-3-6-15(18(14)23)22(24,25)26/h3,5-6,8-10,13,17H,2,4,7,11H2,1H3/t13-,17+/m0/s1
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14.1n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM174824
PNG
(US10053462, 55 | US9102686, 55 | US9540388, 55)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4ccc(Cl)s4)n2C3)c1Cl
Show InChI InChI=1S/C19H13Cl2F3N4OS/c20-14-7-6-13(30-14)17-26-25-16-12-5-4-9(8-27(16)17)28(12)18(29)10-2-1-3-11(15(10)21)19(22,23)24/h1-3,6-7,9,12H,4-5,8H2/t9-,12+/m0/s1
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15.8n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM174817
PNG
(US10053462, 48 | US9102686, 48 | US9540388, 48)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4cccnc4)n2C3)c1Cl
Show InChI InChI=1S/C20H15ClF3N5O/c21-16-13(4-1-5-14(16)20(22,23)24)19(30)29-12-6-7-15(29)18-27-26-17(28(18)10-12)11-3-2-8-25-9-11/h1-5,8-9,12,15H,6-7,10H2/t12-,15+/m0/s1
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15.8n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174815
PNG
(US10053462, 46 | US9102686, 46 | US9540388, 46)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4ncccn4)n2C3)c1Cl
Show InChI InChI=1S/C19H14ClF3N6O/c20-14-11(3-1-4-12(14)19(21,22)23)18(30)29-10-5-6-13(29)16-26-27-17(28(16)9-10)15-24-7-2-8-25-15/h1-4,7-8,10,13H,5-6,9H2/t10-,13+/m0/s1
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15.8n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174819
PNG
(US10053462, 50 | US9102686, 50 | US9540388, 50)
Show SMILES Fc1cnc(nc1)-c1nnc2[C@H]3CC[C@@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C19H13ClF4N6O/c20-14-11(2-1-3-12(14)19(22,23)24)18(31)30-10-4-5-13(30)16-27-28-17(29(16)8-10)15-25-6-9(21)7-26-15/h1-3,6-7,10,13H,4-5,8H2/t10-,13+/m0/s1
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15.8n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174783
PNG
(US10053462, 14 | US9102686, 14 | US9540388, 14)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CCC[C@@H]2c2nnc(-c4cccnc4)n2C3)c1Cl
Show InChI InChI=1S/C21H17ClF3N5O/c22-17-14(6-2-7-15(17)21(23,24)25)20(31)30-13-5-1-8-16(30)19-28-27-18(29(19)11-13)12-4-3-9-26-10-12/h2-4,6-7,9-10,13,16H,1,5,8,11H2/t13-,16+/m0/s1
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17.4n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM203320
PNG
((6r,10s)-11-{[2-chloro-3-(trifluoromethyl)phenyl]c...)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CCC[C@@H]2c2nnc(-c4ccncn4)n2C3)c1Cl
Show InChI InChI=1S/C20H16ClF3N6O/c21-16-12(4-2-5-13(16)20(22,23)24)19(31)30-11-3-1-6-15(30)18-28-27-17(29(18)9-11)14-7-8-25-10-26-14/h2,4-5,7-8,10-11,15H,1,3,6,9H2/t11-,15+/m0/s1
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19.1n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174818
PNG
(US10053462, 49 | US9102686, 49 | US9540388, 49)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4cscn4)n2C3)c1Cl
Show InChI InChI=1S/C18H13ClF3N5OS/c19-14-10(2-1-3-11(14)18(20,21)22)17(28)27-9-4-5-13(27)16-25-24-15(26(16)6-9)12-7-29-8-23-12/h1-3,7-9,13H,4-6H2/t9-,13+/m0/s1
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20n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174773
PNG
(US10053462, 4 | US9102686, 4 | US9540388, 4)
Show SMILES Fc1ccc(cc1)-c1nnc2C3CCCC(Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C22H17ClF4N4O/c23-18-15(4-2-5-16(18)22(25,26)27)21(32)31-14-3-1-6-17(31)20-29-28-19(30(20)11-14)12-7-9-13(24)10-8-12/h2,4-5,7-10,14,17H,1,3,6,11H2
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20n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM203316
PNG
((6r,10s)-11-{[2-chloro-3-(trifluoromethyl)phenyl]c...)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CCC[C@@H]2c2nnc(-c4cccnn4)n2C3)c1Cl
Show InChI InChI=1S/C20H16ClF3N6O/c21-16-12(5-2-6-13(16)20(22,23)24)19(31)30-11-4-1-8-15(30)18-28-27-17(29(18)10-11)14-7-3-9-25-26-14/h2-3,5-7,9,11,15H,1,4,8,10H2/t11-,15+/m0/s1
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20.9n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM203318
PNG
((6r,10s)-11-{[2-chloro-3-(trifluoromethyl)phenyl]c...)
Show SMILES FC(F)(F)c1ccnc(c1)-c1nnc2[C@H]3CCC[C@@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C22H16ClF6N5O/c23-17-13(4-2-5-14(17)22(27,28)29)20(35)34-12-3-1-6-16(34)19-32-31-18(33(19)10-12)15-9-11(7-8-30-15)21(24,25)26/h2,4-5,7-9,12,16H,1,3,6,10H2/t12-,16+/m0/s1
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21.9n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174829
PNG
(US10053462, 60 | US9102686, 60 | US9540388, 60)
Show SMILES FC(F)(F)c1nccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4ccc(Cl)s4)n2C3)c1Cl
Show InChI InChI=1S/C18H12Cl2F3N5OS/c19-12-4-3-11(30-12)16-26-25-15-10-2-1-8(7-27(15)16)28(10)17(29)9-5-6-24-14(13(9)20)18(21,22)23/h3-6,8,10H,1-2,7H2/t8-,10+/m0/s1
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21.9n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174809
PNG
(US10053462, 40 | US9102686, 40 | US9540388, 40)
Show SMILES Fc1ccc(cc1)-c1nnc2[C@H]3CC[C@@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C21H15ClF4N4O/c22-17-14(2-1-3-15(17)21(24,25)26)20(31)30-13-8-9-16(30)19-28-27-18(29(19)10-13)11-4-6-12(23)7-5-11/h1-7,13,16H,8-10H2/t13-,16+/m0/s1
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21.9n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174792
PNG
(US10053462, 23 | US9102686, 23 | US9540388, 23)
Show SMILES Cc1cccc(n1)-c1nnc2[C@H]3CCC[C@@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C22H19ClF3N5O/c1-12-5-2-9-16(27-12)19-28-29-20-17-10-3-6-13(11-30(19)20)31(17)21(32)14-7-4-8-15(18(14)23)22(24,25)26/h2,4-5,7-9,13,17H,3,6,10-11H2,1H3/t13-,17+/m0/s1
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24n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM203324
PNG
((6r,10s)-11-{[3-chloro-2-(trifluoromethyl)pyridin-...)
Show SMILES FC(F)(F)c1nccc(C(=O)N2[C@H]3CCC[C@@H]2c2nnc(-c4ccccn4)n2C3)c1Cl
Show InChI InChI=1S/C20H16ClF3N6O/c21-15-12(7-9-26-16(15)20(22,23)24)19(31)30-11-4-3-6-14(30)18-28-27-17(29(18)10-11)13-5-1-2-8-25-13/h1-2,5,7-9,11,14H,3-4,6,10H2/t11-,14+/m0/s1
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25.1n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174824
PNG
(US10053462, 55 | US9102686, 55 | US9540388, 55)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4ccc(Cl)s4)n2C3)c1Cl
Show InChI InChI=1S/C19H13Cl2F3N4OS/c20-14-7-6-13(30-14)17-26-25-16-12-5-4-9(8-27(16)17)28(12)18(29)10-2-1-3-11(15(10)21)19(22,23)24/h1-3,6-7,9,12H,4-5,8H2/t9-,12+/m0/s1
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25.1n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174808
PNG
(US10053462, 39 | US9102686, 39 | US9540388, 39)
Show SMILES Cc1ccc(s1)-c1nnc2[C@@H]3CCC[C@H](Cn12)N3C(=O)c1ccnc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C20H17ClF3N5OS/c1-10-5-6-14(31-10)18-27-26-17-13-4-2-3-11(9-28(17)18)29(13)19(30)12-7-8-25-16(15(12)21)20(22,23)24/h5-8,11,13H,2-4,9H2,1H3/t11-,13+/m1/s1
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25.1n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174823
PNG
(US10053462, 54 | US9102686, 54 | US9540388, 54)
Show SMILES Fc1c(Cl)ccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4cscn4)n2C3)c1Cl
Show InChI InChI=1S/C17H12Cl2FN5OS/c18-10-3-2-9(13(19)14(10)20)17(26)25-8-1-4-12(25)16-23-22-15(24(16)5-8)11-6-27-7-21-11/h2-3,6-8,12H,1,4-5H2/t8-,12+/m0/s1
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25.1n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174795
PNG
(US10053462, 26 | US9102686, 26 | US9540388, 26)
Show SMILES COc1ccnc(c1)-c1nnc2[C@H]3CCC[C@@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C22H19ClF3N5O2/c1-33-13-8-9-27-16(10-13)19-28-29-20-17-7-2-4-12(11-30(19)20)31(17)21(32)14-5-3-6-15(18(14)23)22(24,25)26/h3,5-6,8-10,12,17H,2,4,7,11H2,1H3/t12-,17+/m0/s1
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30.4n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM174814
PNG
(US10053462, 45 | US9102686, 45 | US9540388, 45)
Show SMILES Fc1ccc(nc1)-c1nnc2[C@H]3CC[C@@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C20H14ClF4N5O/c21-16-12(2-1-3-13(16)20(23,24)25)19(31)30-11-5-7-15(30)18-28-27-17(29(18)9-11)14-6-4-10(22)8-26-14/h1-4,6,8,11,15H,5,7,9H2/t11-,15+/m0/s1
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31.6n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174821
PNG
(US10053462, 52 | US9102686, 52 | US9540388, 52)
Show SMILES Fc1ccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4cscn4)n2C3)c(Cl)c1C(F)(F)F
Show InChI InChI=1S/C18H12ClF4N5OS/c19-14-9(2-3-10(20)13(14)18(21,22)23)17(29)28-8-1-4-12(28)16-26-25-15(27(16)5-8)11-6-30-7-24-11/h2-3,6-8,12H,1,4-5H2/t8-,12+/m0/s1
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31.6n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174826
PNG
(US10053462, 57 | US9102686, 57 | US9540388, 57)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4cncs4)n2C3)c1Cl
Show InChI InChI=1S/C18H13ClF3N5OS/c19-14-10(2-1-3-11(14)18(20,21)22)17(28)27-9-4-5-12(27)15-24-25-16(26(15)7-9)13-6-23-8-29-13/h1-3,6,8-9,12H,4-5,7H2/t9-,12+/m0/s1
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35.5n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174799
PNG
(US10053462, 30 | US9102686, 30 | US9540388, 30)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@@H]3CCC[C@H]2c2nnc(-c4ccc(Cl)cn4)n2C3)c1Cl
Show InChI InChI=1S/C21H16Cl2F3N5O/c22-11-7-8-15(27-9-11)18-28-29-19-16-6-1-3-12(10-30(18)19)31(16)20(32)13-4-2-5-14(17(13)23)21(24,25)26/h2,4-5,7-9,12,16H,1,3,6,10H2/t12-,16+/m1/s1
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35.5n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM174809
PNG
(US10053462, 40 | US9102686, 40 | US9540388, 40)
Show SMILES Fc1ccc(cc1)-c1nnc2[C@H]3CC[C@@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C21H15ClF4N4O/c22-17-14(2-1-3-15(17)21(24,25)26)20(31)30-13-8-9-16(30)19-28-27-18(29(19)10-13)11-4-6-12(23)7-5-11/h1-7,13,16H,8-10H2/t13-,16+/m0/s1
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35.5n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174772
PNG
(US10053462, 3 | US9102686, 3 | US9540388, 3)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@@H]3CCC[C@H]2c2nnc(-c4ncccn4)n2C3)c1Cl
Show InChI InChI=1S/C20H16ClF3N6O/c21-15-12(5-2-6-13(15)20(22,23)24)19(31)30-11-4-1-7-14(30)17-27-28-18(29(17)10-11)16-25-8-3-9-26-16/h2-3,5-6,8-9,11,14H,1,4,7,10H2/t11-,14+/m1/s1
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39.8n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174825
PNG
(US10053462, 56 | US9102686, 56 | US9540388, 56)
Show SMILES Cc1nc(cs1)-c1nnc2[C@H]3CC[C@@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C19H15ClF3N5OS/c1-9-24-13(8-30-9)16-25-26-17-14-6-5-10(7-27(16)17)28(14)18(29)11-3-2-4-12(15(11)20)19(21,22)23/h2-4,8,10,14H,5-7H2,1H3/t10-,14+/m0/s1
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39.8n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174820
PNG
(US10053462, 51 | US9102686, 51 | US9540388, 51)
Show SMILES Cc1cc([nH]n1)-c1nnc2[C@H]3CC[C@@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C19H16ClF3N6O/c1-9-7-13(25-24-9)16-26-27-17-14-6-5-10(8-28(16)17)29(14)18(30)11-3-2-4-12(15(11)20)19(21,22)23/h2-4,7,10,14H,5-6,8H2,1H3,(H,24,25)/t10-,14+/m0/s1
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39.8n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174817
PNG
(US10053462, 48 | US9102686, 48 | US9540388, 48)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4cccnc4)n2C3)c1Cl
Show InChI InChI=1S/C20H15ClF3N5O/c21-16-13(4-1-5-14(16)20(22,23)24)19(30)29-12-6-7-15(29)18-27-26-17(28(18)10-12)11-3-2-8-25-9-11/h1-5,8-9,12,15H,6-7,10H2/t12-,15+/m0/s1
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39.8n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174770
PNG
(US10053462, 1 | US9102686, 1 | US9540388, 1)
Show SMILES FC(F)(F)c1cccc(C(=O)N2C3CCCC2c2nnc(-c4ncccn4)n2C3)c1Cl
Show InChI InChI=1S/C20H16ClF3N6O/c21-15-12(5-2-6-13(15)20(22,23)24)19(31)30-11-4-1-7-14(30)17-27-28-18(29(17)10-11)16-25-8-3-9-26-16/h2-3,5-6,8-9,11,14H,1,4,7,10H2
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50.1n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174790
PNG
(US10053462, 21 | US9102686, 21 | US9540388, 21)
Show SMILES Fc1cnc(nc1)-c1nnc2[C@@H]3CCC[C@H](Cn12)N3C(=O)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C19H15Cl2FN6O/c20-10-4-5-13(14(21)6-10)19(29)28-12-2-1-3-15(28)17-25-26-18(27(17)9-12)16-23-7-11(22)8-24-16/h4-8,12,15H,1-3,9H2/t12-,15+/m1/s1
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50.1n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM203320
PNG
((6r,10s)-11-{[2-chloro-3-(trifluoromethyl)phenyl]c...)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CCC[C@@H]2c2nnc(-c4ccncn4)n2C3)c1Cl
Show InChI InChI=1S/C20H16ClF3N6O/c21-16-12(4-2-5-13(16)20(22,23)24)19(31)30-11-3-1-6-15(30)18-28-27-17(29(18)9-11)14-7-8-25-10-26-14/h2,4-5,7-8,10-11,15H,1,3,6,9H2/t11-,15+/m0/s1
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63.1n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM203314
PNG
((6r,10s)-11-{[2-chloro-3-(trifluoromethyl)phenyl]c...)
Show SMILES Cc1nc(ccc1F)-c1nnc2[C@H]3CCC[C@@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C22H18ClF4N5O/c1-11-15(24)8-9-16(28-11)19-29-30-20-17-7-2-4-12(10-31(19)20)32(17)21(33)13-5-3-6-14(18(13)23)22(25,26)27/h3,5-6,8-9,12,17H,2,4,7,10H2,1H3/t12-,17+/m0/s1
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70.8n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174828
PNG
(US10053462, 59 | US9102686, 59 | US9540388, 59)
Show SMILES Cc1ncsc1-c1nnc2[C@H]3CC[C@@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C19H15ClF3N5OS/c1-9-15(30-8-24-9)17-26-25-16-13-6-5-10(7-27(16)17)28(13)18(29)11-3-2-4-12(14(11)20)19(21,22)23/h2-4,8,10,13H,5-7H2,1H3/t10-,13+/m0/s1
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126n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174778
PNG
(US10053462, 9 | US9102686, 9 | US9540388, 9)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@@H]3CCC[C@H]2c2nnc(-c4cscn4)n2C3)c1Cl
Show InChI InChI=1S/C19H15ClF3N5OS/c20-15-11(4-2-5-12(15)19(21,22)23)18(29)28-10-3-1-6-14(28)17-26-25-16(27(17)7-10)13-8-30-9-24-13/h2,4-5,8-10,14H,1,3,6-7H2/t10-,14+/m1/s1
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398n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174787
PNG
(US10053462, 18 | US9102686, 18 | US9540388, 18)
Show SMILES Fc1cnc(nc1)-c1nnc2[C@@H]3CCC[C@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C20H15ClF4N6O/c21-15-12(4-2-5-13(15)20(23,24)25)19(32)31-11-3-1-6-14(31)17-28-29-18(30(17)9-11)16-26-7-10(22)8-27-16/h2,4-5,7-8,11,14H,1,3,6,9H2/t11-,14+/m1/s1
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n/an/a 1.10n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


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More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM174795
PNG
(US10053462, 26 | US9102686, 26 | US9540388, 26)
Show SMILES COc1ccnc(c1)-c1nnc2[C@H]3CCC[C@@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C22H19ClF3N5O2/c1-33-13-8-9-27-16(10-13)19-28-29-20-17-7-2-4-12(11-30(19)20)31(17)21(32)14-5-3-6-15(18(14)23)22(24,25)26/h3,5-6,8-10,12,17H,2,4,7,11H2,1H3/t12-,17+/m0/s1
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n/an/a 1.40n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM203318
PNG
((6r,10s)-11-{[2-chloro-3-(trifluoromethyl)phenyl]c...)
Show SMILES FC(F)(F)c1ccnc(c1)-c1nnc2[C@H]3CCC[C@@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C22H16ClF6N5O/c23-17-13(4-2-5-14(17)22(27,28)29)20(35)34-12-3-1-6-16(34)19-32-31-18(33(19)10-12)15-9-11(7-8-30-15)21(24,25)26/h2,4-5,7-9,12,16H,1,3,6,10H2/t12-,16+/m0/s1
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n/an/a 1.60n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM203318
PNG
((6r,10s)-11-{[2-chloro-3-(trifluoromethyl)phenyl]c...)
Show SMILES FC(F)(F)c1ccnc(c1)-c1nnc2[C@H]3CCC[C@@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C22H16ClF6N5O/c23-17-13(4-2-5-14(17)22(27,28)29)20(35)34-12-3-1-6-16(34)19-32-31-18(33(19)10-12)15-9-11(7-8-30-15)21(24,25)26/h2,4-5,7-9,12,16H,1,3,6,10H2/t12-,16+/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174827
PNG
(US10053462, 58 | US9102686, 58 | US9540388, 58)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4ccsc4)n2C3)c1Cl
Show InChI InChI=1S/C19H14ClF3N4OS/c20-15-12(2-1-3-13(15)19(21,22)23)18(28)27-11-4-5-14(27)17-25-24-16(26(17)8-11)10-6-7-29-9-10/h1-3,6-7,9,11,14H,4-5,8H2/t11-,14+/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM174777
PNG
(US10053462, 8 | US9102686, 8 | US9540388, 8)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CCC[C@@H]2c2nnc(-c4cscn4)n2C3)c1Cl
Show InChI InChI=1S/C19H15ClF3N5OS/c20-15-11(4-2-5-12(15)19(21,22)23)18(29)28-10-3-1-6-14(28)17-26-25-16(27(17)7-10)13-8-30-9-24-13/h2,4-5,8-10,14H,1,3,6-7H2/t10-,14+/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174830
PNG
(US10053462, 61 | US9102686, 61 | US9540388, 61)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4cccs4)n2C3)c1Cl
Show InChI InChI=1S/C19H14ClF3N4OS/c20-15-11(3-1-4-12(15)19(21,22)23)18(28)27-10-6-7-13(27)16-24-25-17(26(16)9-10)14-5-2-8-29-14/h1-5,8,10,13H,6-7,9H2/t10-,13+/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174822
PNG
(US10053462, 53 | US9102686, 53 | US9540388, 53)
Show SMILES Cc1c(cccc1C(F)(F)F)C(=O)N1[C@H]2CC[C@@H]1c1nnc(-c3cscn3)n1C2
Show InChI InChI=1S/C19H16F3N5OS/c1-10-12(3-2-4-13(10)19(20,21)22)18(28)27-11-5-6-15(27)17-25-24-16(26(17)7-11)14-8-29-9-23-14/h2-4,8-9,11,15H,5-7H2,1H3/t11-,15+/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174770
PNG
(US10053462, 1 | US9102686, 1 | US9540388, 1)
Show SMILES FC(F)(F)c1cccc(C(=O)N2C3CCCC2c2nnc(-c4ncccn4)n2C3)c1Cl
Show InChI InChI=1S/C20H16ClF3N6O/c21-15-12(5-2-6-13(15)20(22,23)24)19(31)30-11-4-1-7-14(30)17-27-28-18(29(17)10-11)16-25-8-3-9-26-16/h2-3,5-6,8-9,11,14H,1,4,7,10H2
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Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM174787
PNG
(US10053462, 18 | US9102686, 18 | US9540388, 18)
Show SMILES Fc1cnc(nc1)-c1nnc2[C@@H]3CCC[C@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C20H15ClF4N6O/c21-15-12(4-2-5-13(15)20(23,24)25)19(32)31-11-3-1-6-14(31)17-28-29-18(30(17)9-11)16-26-7-10(22)8-27-16/h2,4-5,7-8,11,14H,1,3,6,9H2/t11-,14+/m1/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM174770
PNG
(US10053462, 1 | US9102686, 1 | US9540388, 1)
Show SMILES FC(F)(F)c1cccc(C(=O)N2C3CCCC2c2nnc(-c4ncccn4)n2C3)c1Cl
Show InChI InChI=1S/C20H16ClF3N6O/c21-15-12(5-2-6-13(15)20(22,23)24)19(31)30-11-4-1-7-14(30)17-27-28-18(29(17)10-11)16-25-8-3-9-26-16/h2-3,5-6,8-9,11,14H,1,4,7,10H2
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Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174818
PNG
(US10053462, 49 | US9102686, 49 | US9540388, 49)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4cscn4)n2C3)c1Cl
Show InChI InChI=1S/C18H13ClF3N5OS/c19-14-10(2-1-3-11(14)18(20,21)22)17(28)27-9-4-5-13(27)16-25-24-15(26(16)6-9)12-7-29-8-23-12/h1-3,7-9,13H,4-6H2/t9-,13+/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174823
PNG
(US10053462, 54 | US9102686, 54 | US9540388, 54)
Show SMILES Fc1c(Cl)ccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4cscn4)n2C3)c1Cl
Show InChI InChI=1S/C17H12Cl2FN5OS/c18-10-3-2-9(13(19)14(10)20)17(26)25-8-1-4-12(25)16-23-22-15(24(16)5-8)11-6-27-7-21-11/h2-3,6-8,12H,1,4-5H2/t8-,12+/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174810
PNG
(US10053462, 41 | US9102686, 41 | US9540388, 41)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4ccccn4)n2C3)c1Cl
Show InChI InChI=1S/C20H15ClF3N5O/c21-16-12(4-3-5-13(16)20(22,23)24)19(30)29-11-7-8-15(29)18-27-26-17(28(18)10-11)14-6-1-2-9-25-14/h1-6,9,11,15H,7-8,10H2/t11-,15+/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM203315
PNG
((6r,10s)-11-{[2-chloro-3-(trifluoromethyl)phenyl]c...)
Show SMILES Cc1ccnc(c1)-c1nnc2[C@H]3CCC[C@@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C22H19ClF3N5O/c1-12-8-9-27-16(10-12)19-28-29-20-17-7-2-4-13(11-30(19)20)31(17)21(32)14-5-3-6-15(18(14)23)22(24,25)26/h3,5-6,8-10,13,17H,2,4,7,11H2,1H3/t13-,17+/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174813
PNG
(US10053462, 44 | US9102686, 44 | US9540388, 44)
Show SMILES Cc1c(cccc1C(F)(F)F)C(=O)N1[C@H]2CC[C@@H]1c1nnc(-c3ccccn3)n1C2
Show InChI InChI=1S/C21H18F3N5O/c1-12-14(5-4-6-15(12)21(22,23)24)20(30)29-13-8-9-17(29)19-27-26-18(28(19)11-13)16-7-2-3-10-25-16/h2-7,10,13,17H,8-9,11H2,1H3/t13-,17+/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174776
PNG
(US10053462, 7 | US9102686, 7 | US9540388, 7)
Show SMILES FC(F)(F)c1cccc(C(=O)N2C3CCCC2c2nnc(-c4cscn4)n2C3)c1Cl
Show InChI InChI=1S/C19H15ClF3N5OS/c20-15-11(4-2-5-12(15)19(21,22)23)18(29)28-10-3-1-6-14(28)17-26-25-16(27(17)7-10)13-8-30-9-24-13/h2,4-5,8-10,14H,1,3,6-7H2
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Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM174772
PNG
(US10053462, 3 | US9102686, 3 | US9540388, 3)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@@H]3CCC[C@H]2c2nnc(-c4ncccn4)n2C3)c1Cl
Show InChI InChI=1S/C20H16ClF3N6O/c21-15-12(5-2-6-13(15)20(22,23)24)19(31)30-11-4-1-7-14(30)17-27-28-18(29(17)10-11)16-25-8-3-9-26-16/h2-3,5-6,8-9,11,14H,1,4,7,10H2/t11-,14+/m1/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM174783
PNG
(US10053462, 14 | US9102686, 14 | US9540388, 14)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CCC[C@@H]2c2nnc(-c4cccnc4)n2C3)c1Cl
Show InChI InChI=1S/C21H17ClF3N5O/c22-17-14(6-2-7-15(17)21(23,24)25)20(31)30-13-5-1-8-16(30)19-28-27-18(29(19)11-13)12-4-3-9-26-10-12/h2-4,6-7,9-10,13,16H,1,5,8,11H2/t13-,16+/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174772
PNG
(US10053462, 3 | US9102686, 3 | US9540388, 3)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@@H]3CCC[C@H]2c2nnc(-c4ncccn4)n2C3)c1Cl
Show InChI InChI=1S/C20H16ClF3N6O/c21-15-12(5-2-6-13(15)20(22,23)24)19(31)30-11-4-1-7-14(30)17-27-28-18(29(17)10-11)16-25-8-3-9-26-16/h2-3,5-6,8-9,11,14H,1,4,7,10H2/t11-,14+/m1/s1
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n/an/a 9.60n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174777
PNG
(US10053462, 8 | US9102686, 8 | US9540388, 8)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CCC[C@@H]2c2nnc(-c4cscn4)n2C3)c1Cl
Show InChI InChI=1S/C19H15ClF3N5OS/c20-15-11(4-2-5-12(15)19(21,22)23)18(29)28-10-3-1-6-14(28)17-26-25-16(27(17)7-10)13-8-30-9-24-13/h2,4-5,8-10,14H,1,3,6-7H2/t10-,14+/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174795
PNG
(US10053462, 26 | US9102686, 26 | US9540388, 26)
Show SMILES COc1ccnc(c1)-c1nnc2[C@H]3CCC[C@@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C22H19ClF3N5O2/c1-33-13-8-9-27-16(10-13)19-28-29-20-17-7-2-4-12(11-30(19)20)31(17)21(32)14-5-3-6-15(18(14)23)22(24,25)26/h3,5-6,8-10,12,17H,2,4,7,11H2,1H3/t12-,17+/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174783
PNG
(US10053462, 14 | US9102686, 14 | US9540388, 14)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CCC[C@@H]2c2nnc(-c4cccnc4)n2C3)c1Cl
Show InChI InChI=1S/C21H17ClF3N5O/c22-17-14(6-2-7-15(17)21(23,24)25)20(31)30-13-5-1-8-16(30)19-28-27-18(29(19)11-13)12-4-3-9-26-10-12/h2-4,6-7,9-10,13,16H,1,5,8,11H2/t13-,16+/m0/s1
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n/an/a 10n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174821
PNG
(US10053462, 52 | US9102686, 52 | US9540388, 52)
Show SMILES Fc1ccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4cscn4)n2C3)c(Cl)c1C(F)(F)F
Show InChI InChI=1S/C18H12ClF4N5OS/c19-14-9(2-3-10(20)13(14)18(21,22)23)17(29)28-8-1-4-12(28)16-26-25-15(27(16)5-8)11-6-30-7-24-11/h2-3,6-8,12H,1,4-5H2/t8-,12+/m0/s1
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n/an/a 10.2n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM203331
PNG
((6r,10s)-11-{[2-chloro-4-fluoro-3-(trifluoromethyl...)
Show SMILES Fc1ccc(C(=O)N2[C@H]3CCC[C@@H]2c2nnc(-c4ccccn4)n2C3)c(Cl)c1C(F)(F)F
Show InChI InChI=1S/C21H16ClF4N5O/c22-17-12(7-8-13(23)16(17)21(24,25)26)20(32)31-11-4-3-6-15(31)19-29-28-18(30(19)10-11)14-5-1-2-9-27-14/h1-2,5,7-9,11,15H,3-4,6,10H2/t11-,15+/m0/s1
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n/an/a 10.2n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174819
PNG
(US10053462, 50 | US9102686, 50 | US9540388, 50)
Show SMILES Fc1cnc(nc1)-c1nnc2[C@H]3CC[C@@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C19H13ClF4N6O/c20-14-11(2-1-3-12(14)19(22,23)24)18(31)30-10-4-5-13(30)16-27-28-17(29(16)8-10)15-25-6-9(21)7-26-15/h1-3,6-7,10,13H,4-5,8H2/t10-,13+/m0/s1
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n/an/a 10.4n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM203320
PNG
((6r,10s)-11-{[2-chloro-3-(trifluoromethyl)phenyl]c...)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CCC[C@@H]2c2nnc(-c4ccncn4)n2C3)c1Cl
Show InChI InChI=1S/C20H16ClF3N6O/c21-16-12(4-2-5-13(16)20(22,23)24)19(31)30-11-3-1-6-15(30)18-28-27-17(29(18)9-11)14-7-8-25-10-26-14/h2,4-5,7-8,10-11,15H,1,3,6,9H2/t11-,15+/m0/s1
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n/an/a 10.7n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM174802
PNG
(US10053462, 33 | US9102686, 33 | US9540388, 32)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CCC[C@@H]2c2nnc(-c4ccccn4)n2C3)c1Cl
Show InChI InChI=1S/C21H17ClF3N5O/c22-17-13(6-4-7-14(17)21(23,24)25)20(31)30-12-5-3-9-16(30)19-28-27-18(29(19)11-12)15-8-1-2-10-26-15/h1-2,4,6-8,10,12,16H,3,5,9,11H2/t12-,16+/m0/s1
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n/an/a 11.3n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174809
PNG
(US10053462, 40 | US9102686, 40 | US9540388, 40)
Show SMILES Fc1ccc(cc1)-c1nnc2[C@H]3CC[C@@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C21H15ClF4N4O/c22-17-14(2-1-3-15(17)21(24,25)26)20(31)30-13-8-9-16(30)19-28-27-18(29(19)10-13)11-4-6-12(23)7-5-11/h1-7,13,16H,8-10H2/t13-,16+/m0/s1
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n/an/a 12.6n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM203324
PNG
((6r,10s)-11-{[3-chloro-2-(trifluoromethyl)pyridin-...)
Show SMILES FC(F)(F)c1nccc(C(=O)N2[C@H]3CCC[C@@H]2c2nnc(-c4ccccn4)n2C3)c1Cl
Show InChI InChI=1S/C20H16ClF3N6O/c21-15-12(7-9-26-16(15)20(22,23)24)19(31)30-11-4-3-6-14(30)18-28-27-17(29(18)10-11)13-5-1-2-8-25-13/h1-2,5,7-9,11,14H,3-4,6,10H2/t11-,14+/m0/s1
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n/an/a 12.7n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174814
PNG
(US10053462, 45 | US9102686, 45 | US9540388, 45)
Show SMILES Fc1ccc(nc1)-c1nnc2[C@H]3CC[C@@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C20H14ClF4N5O/c21-16-12(2-1-3-13(16)20(23,24)25)19(31)30-11-5-7-15(30)18-28-27-17(29(18)9-11)14-6-4-10(22)8-26-14/h1-4,6,8,11,15H,5,7,9H2/t11-,15+/m0/s1
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n/an/a 13.1n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174817
PNG
(US10053462, 48 | US9102686, 48 | US9540388, 48)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4cccnc4)n2C3)c1Cl
Show InChI InChI=1S/C20H15ClF3N5O/c21-16-13(4-1-5-14(16)20(22,23)24)19(30)29-12-6-7-15(29)18-27-26-17(28(18)10-12)11-3-2-8-25-9-11/h1-5,8-9,12,15H,6-7,10H2/t12-,15+/m0/s1
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n/an/a 13.2n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174781
PNG
(US10053462, 12 | US9102686, 12 | US9540388, 12)
Show SMILES Fc1ccc(nc1)-c1nnc2[C@@H]3CCC[C@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C21H16ClF4N5O/c22-17-13(4-2-5-14(17)21(24,25)26)20(32)31-12-3-1-6-16(31)19-29-28-18(30(19)10-12)15-8-7-11(23)9-27-15/h2,4-5,7-9,12,16H,1,3,6,10H2/t12-,16+/m1/s1
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n/an/a 13.3n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM203331
PNG
((6r,10s)-11-{[2-chloro-4-fluoro-3-(trifluoromethyl...)
Show SMILES Fc1ccc(C(=O)N2[C@H]3CCC[C@@H]2c2nnc(-c4ccccn4)n2C3)c(Cl)c1C(F)(F)F
Show InChI InChI=1S/C21H16ClF4N5O/c22-17-12(7-8-13(23)16(17)21(24,25)26)20(32)31-11-4-3-6-15(31)19-29-28-18(30(19)10-11)14-5-1-2-9-27-14/h1-2,5,7-9,11,15H,3-4,6,10H2/t11-,15+/m0/s1
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n/an/a 13.4n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174802
PNG
(US10053462, 33 | US9102686, 33 | US9540388, 32)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CCC[C@@H]2c2nnc(-c4ccccn4)n2C3)c1Cl
Show InChI InChI=1S/C21H17ClF3N5O/c22-17-13(6-4-7-14(17)21(23,24)25)20(31)30-12-5-3-9-16(30)19-28-27-18(29(19)11-12)15-8-1-2-10-26-15/h1-2,4,6-8,10,12,16H,3,5,9,11H2/t12-,16+/m0/s1
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n/an/a 13.4n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM174818
PNG
(US10053462, 49 | US9102686, 49 | US9540388, 49)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4cscn4)n2C3)c1Cl
Show InChI InChI=1S/C18H13ClF3N5OS/c19-14-10(2-1-3-11(14)18(20,21)22)17(28)27-9-4-5-13(27)16-25-24-15(26(16)6-9)12-7-29-8-23-12/h1-3,7-9,13H,4-6H2/t9-,13+/m0/s1
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n/an/a 13.5n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM203332
PNG
((6r,10s)-11-{[2-methyl-3-(trifluoromethyl)phenyl]c...)
Show SMILES Cc1c(cccc1C(F)(F)F)C(=O)N1[C@H]2CCC[C@@H]1c1nnc(-c3ccccn3)n1C2
Show InChI InChI=1S/C22H20F3N5O/c1-13-15(7-5-8-16(13)22(23,24)25)21(31)30-14-6-4-10-18(30)20-28-27-19(29(20)12-14)17-9-2-3-11-26-17/h2-3,5,7-9,11,14,18H,4,6,10,12H2,1H3/t14-,18+/m0/s1
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n/an/a 14n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174820
PNG
(US10053462, 51 | US9102686, 51 | US9540388, 51)
Show SMILES Cc1cc([nH]n1)-c1nnc2[C@H]3CC[C@@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C19H16ClF3N6O/c1-9-7-13(25-24-9)16-26-27-17-14-6-5-10(8-28(16)17)29(14)18(30)11-3-2-4-12(15(11)20)19(21,22)23/h2-4,7,10,14H,5-6,8H2,1H3,(H,24,25)/t10-,14+/m0/s1
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n/an/a 14.4n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM174774
PNG
(US10053462, 5 | US9102686, 5 | US9540388, 5)
Show SMILES Fc1ccc(cc1)-c1nnc2[C@H]3CCC[C@@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C22H17ClF4N4O/c23-18-15(4-2-5-16(18)22(25,26)27)21(32)31-14-3-1-6-17(31)20-29-28-19(30(20)11-14)12-7-9-13(24)10-8-12/h2,4-5,7-10,14,17H,1,3,6,11H2/t14-,17+/m0/s1
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n/an/a 14.7n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174829
PNG
(US10053462, 60 | US9102686, 60 | US9540388, 60)
Show SMILES FC(F)(F)c1nccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4ccc(Cl)s4)n2C3)c1Cl
Show InChI InChI=1S/C18H12Cl2F3N5OS/c19-12-4-3-11(30-12)16-26-25-15-10-2-1-8(7-27(15)16)28(10)17(29)9-5-6-24-14(13(9)20)18(21,22)23/h3-6,8,10H,1-2,7H2/t8-,10+/m0/s1
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n/an/a 14.9n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174815
PNG
(US10053462, 46 | US9102686, 46 | US9540388, 46)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4ncccn4)n2C3)c1Cl
Show InChI InChI=1S/C19H14ClF3N6O/c20-14-11(3-1-4-12(14)19(21,22)23)18(30)29-10-5-6-13(29)16-26-27-17(28(16)9-10)15-24-7-2-8-25-15/h1-4,7-8,10,13H,5-6,9H2/t10-,13+/m0/s1
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n/an/a 15.2n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM174776
PNG
(US10053462, 7 | US9102686, 7 | US9540388, 7)
Show SMILES FC(F)(F)c1cccc(C(=O)N2C3CCCC2c2nnc(-c4cscn4)n2C3)c1Cl
Show InChI InChI=1S/C19H15ClF3N5OS/c20-15-11(4-2-5-12(15)19(21,22)23)18(29)28-10-3-1-6-14(28)17-26-25-16(27(17)7-10)13-8-30-9-24-13/h2,4-5,8-10,14H,1,3,6-7H2
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n/an/a 15.7n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174824
PNG
(US10053462, 55 | US9102686, 55 | US9540388, 55)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4ccc(Cl)s4)n2C3)c1Cl
Show InChI InChI=1S/C19H13Cl2F3N4OS/c20-14-7-6-13(30-14)17-26-25-16-12-5-4-9(8-27(16)17)28(12)18(29)10-2-1-3-11(15(10)21)19(22,23)24/h1-3,6-7,9,12H,4-5,8H2/t9-,12+/m0/s1
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n/an/a 17.1n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM203315
PNG
((6r,10s)-11-{[2-chloro-3-(trifluoromethyl)phenyl]c...)
Show SMILES Cc1ccnc(c1)-c1nnc2[C@H]3CCC[C@@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C22H19ClF3N5O/c1-12-8-9-27-16(10-12)19-28-29-20-17-7-2-4-13(11-30(19)20)31(17)21(32)14-5-3-6-15(18(14)23)22(24,25)26/h3,5-6,8-10,13,17H,2,4,7,11H2,1H3/t13-,17+/m0/s1
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n/an/a 17.3n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM203333
PNG
((6r,10s)-11-[(2,4-dichloro-3-fluorophenyl)carbonyl...)
Show SMILES Fc1c(Cl)ccc(C(=O)N2[C@H]3CCC[C@@H]2c2nnc(-c4ccccn4)n2C3)c1Cl
Show InChI InChI=1S/C20H16Cl2FN5O/c21-13-8-7-12(16(22)17(13)23)20(29)28-11-4-3-6-15(28)19-26-25-18(27(19)10-11)14-5-1-2-9-24-14/h1-2,5,7-9,11,15H,3-4,6,10H2/t11-,15+/m0/s1
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n/an/a 17.6n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174831
PNG
(US10053462, 62 | US9102686, 62 | US9540388, 62)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4ccc[nH]4)n2C3)c1Cl
Show InChI InChI=1S/C19H15ClF3N5O/c20-15-11(3-1-4-12(15)19(21,22)23)18(29)28-10-6-7-14(28)17-26-25-16(27(17)9-10)13-5-2-8-24-13/h1-5,8,10,14,24H,6-7,9H2/t10-,14+/m0/s1
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n/an/a 19.6n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174812
PNG
(US10053462, 43 | US9102686, 43 | US9540388, 43)
Show SMILES Fc1ccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4ccccn4)n2C3)c(Cl)c1C(F)(F)F
Show InChI InChI=1S/C20H14ClF4N5O/c21-16-11(5-6-12(22)15(16)20(23,24)25)19(31)30-10-4-7-14(30)18-28-27-17(29(18)9-10)13-3-1-2-8-26-13/h1-3,5-6,8,10,14H,4,7,9H2/t10-,14+/m0/s1
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n/an/a 20n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174811
PNG
(US10053462, 42 | US9102686, 42 | US9540388, 42)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4cnccn4)n2C3)c1Cl
Show InChI InChI=1S/C19H14ClF3N6O/c20-15-11(2-1-3-12(15)19(21,22)23)18(30)29-10-4-5-14(29)17-27-26-16(28(17)9-10)13-8-24-6-7-25-13/h1-3,6-8,10,14H,4-5,9H2/t10-,14+/m0/s1
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n/an/a 20n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM203334
PNG
((6r,10s)-11-[(2,3-dichloro-4-fluorophenyl)carbonyl...)
Show SMILES Fc1ccc(C(=O)N2[C@H]3CCC[C@@H]2c2nnc(-c4ccccn4)n2C3)c(Cl)c1Cl
Show InChI InChI=1S/C20H16Cl2FN5O/c21-16-12(7-8-13(23)17(16)22)20(29)28-11-4-3-6-15(28)19-26-25-18(27(19)10-11)14-5-1-2-9-24-14/h1-2,5,7-9,11,15H,3-4,6,10H2/t11-,15+/m0/s1
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n/an/a 20n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174816
PNG
(US10053462, 47 | US9102686, 47 | US9540388, 47)
Show SMILES Fc1ccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4cnccn4)n2C3)c(Cl)c1Cl
Show InChI InChI=1S/C18H13Cl2FN6O/c19-14-10(2-3-11(21)15(14)20)18(28)27-9-1-4-13(27)17-25-24-16(26(17)8-9)12-7-22-5-6-23-12/h2-3,5-7,9,13H,1,4,8H2/t9-,13+/m0/s1
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n/an/a 20.3n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM203323
PNG
((6r,10s)-11-{[3-fluoro-2-(trifluoromethyl)pyridin-...)
Show SMILES Fc1c(ccnc1C(F)(F)F)C(=O)N1[C@H]2CCC[C@@H]1c1nnc(-c3ccccn3)n1C2
Show InChI InChI=1S/C20H16F4N6O/c21-15-12(7-9-26-16(15)20(22,23)24)19(31)30-11-4-3-6-14(30)18-28-27-17(29(18)10-11)13-5-1-2-8-25-13/h1-2,5,7-9,11,14H,3-4,6,10H2/t11-,14+/m0/s1
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n/an/a 20.9n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM203334
PNG
((6r,10s)-11-[(2,3-dichloro-4-fluorophenyl)carbonyl...)
Show SMILES Fc1ccc(C(=O)N2[C@H]3CCC[C@@H]2c2nnc(-c4ccccn4)n2C3)c(Cl)c1Cl
Show InChI InChI=1S/C20H16Cl2FN5O/c21-16-12(7-8-13(23)17(16)22)20(29)28-11-4-3-6-15(28)19-26-25-18(27(19)10-11)14-5-1-2-9-24-14/h1-2,5,7-9,11,15H,3-4,6,10H2/t11-,15+/m0/s1
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n/an/a 25.3n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM203324
PNG
((6r,10s)-11-{[3-chloro-2-(trifluoromethyl)pyridin-...)
Show SMILES FC(F)(F)c1nccc(C(=O)N2[C@H]3CCC[C@@H]2c2nnc(-c4ccccn4)n2C3)c1Cl
Show InChI InChI=1S/C20H16ClF3N6O/c21-15-12(7-9-26-16(15)20(22,23)24)19(31)30-11-4-3-6-14(30)18-28-27-17(29(18)10-11)13-5-1-2-8-25-13/h1-2,5,7-9,11,14H,3-4,6,10H2/t11-,14+/m0/s1
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n/an/a 29.5n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM203314
PNG
((6r,10s)-11-{[2-chloro-3-(trifluoromethyl)phenyl]c...)
Show SMILES Cc1nc(ccc1F)-c1nnc2[C@H]3CCC[C@@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C22H18ClF4N5O/c1-11-15(24)8-9-16(28-11)19-29-30-20-17-7-2-4-12(10-31(19)20)32(17)21(33)13-5-3-6-14(18(13)23)22(25,26)27/h3,5-6,8-9,12,17H,2,4,7,10H2,1H3/t12-,17+/m0/s1
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n/an/a 30.7n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174825
PNG
(US10053462, 56 | US9102686, 56 | US9540388, 56)
Show SMILES Cc1nc(cs1)-c1nnc2[C@H]3CC[C@@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C19H15ClF3N5OS/c1-9-24-13(8-30-9)16-25-26-17-14-6-5-10(7-27(16)17)28(14)18(29)11-3-2-4-12(15(11)20)19(21,22)23/h2-4,8,10,14H,5-7H2,1H3/t10-,14+/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174805
PNG
(US10053462, 36 | US9102686, 36 | US9540388, 36)
Show SMILES FC(F)(F)c1nccc(C(=O)N2[C@@H]3CCC[C@H]2c2nnc(-c4cccs4)n2C3)c1Cl
Show InChI InChI=1S/C19H15ClF3N5OS/c20-14-11(6-7-24-15(14)19(21,22)23)18(29)28-10-3-1-4-12(28)16-25-26-17(27(16)9-10)13-5-2-8-30-13/h2,5-8,10,12H,1,3-4,9H2/t10-,12+/m1/s1
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n/an/a 36.5n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM174781
PNG
(US10053462, 12 | US9102686, 12 | US9540388, 12)
Show SMILES Fc1ccc(nc1)-c1nnc2[C@@H]3CCC[C@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C21H16ClF4N5O/c22-17-13(4-2-5-14(17)21(24,25)26)20(32)31-12-3-1-6-16(31)19-29-28-18(30(19)10-12)15-8-7-11(23)9-27-15/h2,4-5,7-9,12,16H,1,3,6,10H2/t12-,16+/m1/s1
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n/an/a 36.6n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM203316
PNG
((6r,10s)-11-{[2-chloro-3-(trifluoromethyl)phenyl]c...)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CCC[C@@H]2c2nnc(-c4cccnn4)n2C3)c1Cl
Show InChI InChI=1S/C20H16ClF3N6O/c21-16-12(5-2-6-13(16)20(22,23)24)19(31)30-11-4-1-8-15(30)18-28-27-17(29(18)10-11)14-7-3-9-25-26-14/h2-3,5-7,9,11,15H,1,4,8,10H2/t11-,15+/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174792
PNG
(US10053462, 23 | US9102686, 23 | US9540388, 23)
Show SMILES Cc1cccc(n1)-c1nnc2[C@H]3CCC[C@@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C22H19ClF3N5O/c1-12-5-2-9-16(27-12)19-28-29-20-17-10-3-6-13(11-30(19)20)31(17)21(32)14-7-4-8-15(18(14)23)22(24,25)26/h2,4-5,7-9,13,17H,3,6,10-11H2,1H3/t13-,17+/m0/s1
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n/an/a 40.4n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM203314
PNG
((6r,10s)-11-{[2-chloro-3-(trifluoromethyl)phenyl]c...)
Show SMILES Cc1nc(ccc1F)-c1nnc2[C@H]3CCC[C@@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C22H18ClF4N5O/c1-11-15(24)8-9-16(28-11)19-29-30-20-17-7-2-4-12(10-31(19)20)32(17)21(33)13-5-3-6-14(18(13)23)22(25,26)27/h3,5-6,8-9,12,17H,2,4,7,10H2,1H3/t12-,17+/m0/s1
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n/an/a 41.1n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174808
PNG
(US10053462, 39 | US9102686, 39 | US9540388, 39)
Show SMILES Cc1ccc(s1)-c1nnc2[C@@H]3CCC[C@H](Cn12)N3C(=O)c1ccnc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C20H17ClF3N5OS/c1-10-5-6-14(31-10)18-27-26-17-13-4-2-3-11(9-28(17)18)29(13)19(30)12-7-8-25-16(15(12)21)20(22,23)24/h5-8,11,13H,2-4,9H2,1H3/t11-,13+/m1/s1
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n/an/a 51.1n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM174792
PNG
(US10053462, 23 | US9102686, 23 | US9540388, 23)
Show SMILES Cc1cccc(n1)-c1nnc2[C@H]3CCC[C@@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C22H19ClF3N5O/c1-12-5-2-9-16(27-12)19-28-29-20-17-10-3-6-13(11-30(19)20)31(17)21(32)14-7-4-8-15(18(14)23)22(24,25)26/h2,4-5,7-9,13,17H,3,6,10-11H2,1H3/t13-,17+/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174774
PNG
(US10053462, 5 | US9102686, 5 | US9540388, 5)
Show SMILES Fc1ccc(cc1)-c1nnc2[C@H]3CCC[C@@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C22H17ClF4N4O/c23-18-15(4-2-5-16(18)22(25,26)27)21(32)31-14-3-1-6-17(31)20-29-28-19(30(20)11-14)12-7-9-13(24)10-8-12/h2,4-5,7-10,14,17H,1,3,6,11H2/t14-,17+/m0/s1
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n/an/a 63.4n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM174808
PNG
(US10053462, 39 | US9102686, 39 | US9540388, 39)
Show SMILES Cc1ccc(s1)-c1nnc2[C@@H]3CCC[C@H](Cn12)N3C(=O)c1ccnc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C20H17ClF3N5OS/c1-10-5-6-14(31-10)18-27-26-17-13-4-2-3-11(9-28(17)18)29(13)19(30)12-7-8-25-16(15(12)21)20(22,23)24/h5-8,11,13H,2-4,9H2,1H3/t11-,13+/m1/s1
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n/an/a 79.8n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174790
PNG
(US10053462, 21 | US9102686, 21 | US9540388, 21)
Show SMILES Fc1cnc(nc1)-c1nnc2[C@@H]3CCC[C@H](Cn12)N3C(=O)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C19H15Cl2FN6O/c20-10-4-5-13(14(21)6-10)19(29)28-12-2-1-3-15(28)17-25-26-18(27(17)9-12)16-23-7-11(22)8-24-16/h4-8,12,15H,1-3,9H2/t12-,15+/m1/s1
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n/an/a 94.8n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174773
PNG
(US10053462, 4 | US9102686, 4 | US9540388, 4)
Show SMILES Fc1ccc(cc1)-c1nnc2C3CCCC(Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C22H17ClF4N4O/c23-18-15(4-2-5-16(18)22(25,26)27)21(32)31-14-3-1-6-17(31)20-29-28-19(30(20)11-14)12-7-9-13(24)10-8-12/h2,4-5,7-10,14,17H,1,3,6,11H2
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n/an/a 95.3n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174826
PNG
(US10053462, 57 | US9102686, 57 | US9540388, 57)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4cncs4)n2C3)c1Cl
Show InChI InChI=1S/C18H13ClF3N5OS/c19-14-10(2-1-3-11(14)18(20,21)22)17(28)27-9-4-5-12(27)15-24-25-16(26(15)7-9)13-6-23-8-29-13/h1-3,6,8-9,12H,4-5,7H2/t9-,12+/m0/s1
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n/an/a 97.7n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174828
PNG
(US10053462, 59 | US9102686, 59 | US9540388, 59)
Show SMILES Cc1ncsc1-c1nnc2[C@H]3CC[C@@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C19H15ClF3N5OS/c1-9-15(30-8-24-9)17-26-25-16-13-6-5-10(7-27(16)17)28(13)18(29)11-3-2-4-12(14(11)20)19(21,22)23/h2-4,8,10,13H,5-7H2,1H3/t10-,13+/m0/s1
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n/an/a 100n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174799
PNG
(US10053462, 30 | US9102686, 30 | US9540388, 30)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@@H]3CCC[C@H]2c2nnc(-c4ccc(Cl)cn4)n2C3)c1Cl
Show InChI InChI=1S/C21H16Cl2F3N5O/c22-11-7-8-15(27-9-11)18-28-29-19-16-6-1-3-12(10-30(18)19)31(16)20(32)13-4-2-5-14(17(13)23)21(24,25)26/h2,4-5,7-9,12,16H,1,3,6,10H2/t12-,16+/m1/s1
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n/an/a 118n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM174821
PNG
(US10053462, 52 | US9102686, 52 | US9540388, 52)
Show SMILES Fc1ccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4cscn4)n2C3)c(Cl)c1C(F)(F)F
Show InChI InChI=1S/C18H12ClF4N5OS/c19-14-9(2-3-10(20)13(14)18(21,22)23)17(29)28-8-1-4-12(28)16-26-25-15(27(16)5-8)11-6-30-7-24-11/h2-3,6-8,12H,1,4-5H2/t8-,12+/m0/s1
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n/an/a 131n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM174773
PNG
(US10053462, 4 | US9102686, 4 | US9540388, 4)
Show SMILES Fc1ccc(cc1)-c1nnc2C3CCCC(Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C22H17ClF4N4O/c23-18-15(4-2-5-16(18)22(25,26)27)21(32)31-14-3-1-6-17(31)20-29-28-19(30(20)11-14)12-7-9-13(24)10-8-12/h2,4-5,7-10,14,17H,1,3,6,11H2
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n/an/a 133n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM174778
PNG
(US10053462, 9 | US9102686, 9 | US9540388, 9)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@@H]3CCC[C@H]2c2nnc(-c4cscn4)n2C3)c1Cl
Show InChI InChI=1S/C19H15ClF3N5OS/c20-15-11(4-2-5-12(15)19(21,22)23)18(29)28-10-3-1-6-14(28)17-26-25-16(27(17)7-10)13-8-30-9-24-13/h2,4-5,8-10,14H,1,3,6-7H2/t10-,14+/m1/s1
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n/an/a 180n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM174811
PNG
(US10053462, 42 | US9102686, 42 | US9540388, 42)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4cnccn4)n2C3)c1Cl
Show InChI InChI=1S/C19H14ClF3N6O/c20-15-11(2-1-3-12(15)19(21,22)23)18(30)29-10-4-5-14(29)17-27-26-16(28(17)9-10)13-8-24-6-7-25-13/h1-3,6-8,10,14H,4-5,9H2/t10-,14+/m0/s1
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n/an/a 251n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM174815
PNG
(US10053462, 46 | US9102686, 46 | US9540388, 46)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4ncccn4)n2C3)c1Cl
Show InChI InChI=1S/C19H14ClF3N6O/c20-14-11(3-1-4-12(14)19(21,22)23)18(30)29-10-5-6-13(29)16-26-27-17(28(16)9-10)15-24-7-2-8-25-15/h1-4,7-8,10,13H,5-6,9H2/t10-,13+/m0/s1
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n/an/a 253n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM203323
PNG
((6r,10s)-11-{[3-fluoro-2-(trifluoromethyl)pyridin-...)
Show SMILES Fc1c(ccnc1C(F)(F)F)C(=O)N1[C@H]2CCC[C@@H]1c1nnc(-c3ccccn3)n1C2
Show InChI InChI=1S/C20H16F4N6O/c21-15-12(7-9-26-16(15)20(22,23)24)19(31)30-11-4-3-6-14(30)18-28-27-17(29(18)10-11)13-5-1-2-8-25-13/h1-2,5,7-9,11,14H,3-4,6,10H2/t11-,14+/m0/s1
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n/an/a 327n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM174805
PNG
(US10053462, 36 | US9102686, 36 | US9540388, 36)
Show SMILES FC(F)(F)c1nccc(C(=O)N2[C@@H]3CCC[C@H]2c2nnc(-c4cccs4)n2C3)c1Cl
Show InChI InChI=1S/C19H15ClF3N5OS/c20-14-11(6-7-24-15(14)19(21,22)23)18(29)28-10-3-1-4-12(28)16-25-26-17(27(16)9-10)13-5-2-8-30-13/h2,5-8,10,12H,1,3-4,9H2/t10-,12+/m1/s1
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n/an/a 338n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM203333
PNG
((6r,10s)-11-[(2,4-dichloro-3-fluorophenyl)carbonyl...)
Show SMILES Fc1c(Cl)ccc(C(=O)N2[C@H]3CCC[C@@H]2c2nnc(-c4ccccn4)n2C3)c1Cl
Show InChI InChI=1S/C20H16Cl2FN5O/c21-13-8-7-12(16(22)17(13)23)20(29)28-11-4-3-6-15(28)19-26-25-18(27(19)10-11)14-5-1-2-9-24-14/h1-2,5,7-9,11,15H,3-4,6,10H2/t11-,15+/m0/s1
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n/an/a 462n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174778
PNG
(US10053462, 9 | US9102686, 9 | US9540388, 9)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@@H]3CCC[C@H]2c2nnc(-c4cscn4)n2C3)c1Cl
Show InChI InChI=1S/C19H15ClF3N5OS/c20-15-11(4-2-5-12(15)19(21,22)23)18(29)28-10-3-1-6-14(28)17-26-25-16(27(17)7-10)13-8-30-9-24-13/h2,4-5,8-10,14H,1,3,6-7H2/t10-,14+/m1/s1
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n/an/a 482n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM174827
PNG
(US10053462, 58 | US9102686, 58 | US9540388, 58)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4ccsc4)n2C3)c1Cl
Show InChI InChI=1S/C19H14ClF3N4OS/c20-15-12(2-1-3-13(15)19(21,22)23)18(28)27-11-4-5-14(27)17-25-24-16(26(17)8-11)10-6-7-29-9-10/h1-3,6-7,9,11,14H,4-5,8H2/t11-,14+/m0/s1
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n/an/a 713n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM203332
PNG
((6r,10s)-11-{[2-methyl-3-(trifluoromethyl)phenyl]c...)
Show SMILES Cc1c(cccc1C(F)(F)F)C(=O)N1[C@H]2CCC[C@@H]1c1nnc(-c3ccccn3)n1C2
Show InChI InChI=1S/C22H20F3N5O/c1-13-15(7-5-8-16(13)22(23,24)25)21(31)30-14-6-4-10-18(30)20-28-27-19(29(20)12-14)17-9-2-3-11-26-17/h2-3,5,7-9,11,14,18H,4,6,10,12H2,1H3/t14-,18+/m0/s1
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n/an/a 726n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM203320
PNG
((6r,10s)-11-{[2-chloro-3-(trifluoromethyl)phenyl]c...)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CCC[C@@H]2c2nnc(-c4ccncn4)n2C3)c1Cl
Show InChI InChI=1S/C20H16ClF3N6O/c21-16-12(4-2-5-13(16)20(22,23)24)19(31)30-11-3-1-6-15(30)18-28-27-17(29(18)9-11)14-7-8-25-10-26-14/h2,4-5,7-8,10-11,15H,1,3,6,9H2/t11-,15+/m0/s1
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n/an/a 1.49E+3n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM174796
PNG
(US10053462, 27 | US9102686, 27 | US9540388, 27)
Show SMILES COc1ccnc(c1)-c1nnc2[C@@H]3CCC[C@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C22H19ClF3N5O2/c1-33-13-8-9-27-16(10-13)19-28-29-20-17-7-2-4-12(11-30(19)20)31(17)21(32)14-5-3-6-15(18(14)23)22(24,25)26/h3,5-6,8-10,12,17H,2,4,7,11H2,1H3/t12-,17+/m1/s1
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n/an/a 1.54E+3n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM174810
PNG
(US10053462, 41 | US9102686, 41 | US9540388, 41)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4ccccn4)n2C3)c1Cl
Show InChI InChI=1S/C20H15ClF3N5O/c21-16-12(4-3-5-13(16)20(22,23)24)19(30)29-11-7-8-15(29)18-27-26-17(28(18)10-11)14-6-1-2-9-25-14/h1-6,9,11,15H,7-8,10H2/t11-,15+/m0/s1
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n/an/a 1.59E+3n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174796
PNG
(US10053462, 27 | US9102686, 27 | US9540388, 27)
Show SMILES COc1ccnc(c1)-c1nnc2[C@@H]3CCC[C@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C22H19ClF3N5O2/c1-33-13-8-9-27-16(10-13)19-28-29-20-17-7-2-4-12(11-30(19)20)31(17)21(32)14-5-3-6-15(18(14)23)22(24,25)26/h3,5-6,8-10,12,17H,2,4,7,11H2,1H3/t12-,17+/m1/s1
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n/an/a 1.91E+3n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM174816
PNG
(US10053462, 47 | US9102686, 47 | US9540388, 47)
Show SMILES Fc1ccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4cnccn4)n2C3)c(Cl)c1Cl
Show InChI InChI=1S/C18H13Cl2FN6O/c19-14-10(2-3-11(21)15(14)20)18(28)27-9-1-4-13(27)17-25-24-16(26(17)8-9)12-7-22-5-6-23-12/h2-3,5-7,9,13H,1,4,8H2/t9-,13+/m0/s1
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n/an/a 1.92E+3n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM174824
PNG
(US10053462, 55 | US9102686, 55 | US9540388, 55)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4ccc(Cl)s4)n2C3)c1Cl
Show InChI InChI=1S/C19H13Cl2F3N4OS/c20-14-7-6-13(30-14)17-26-25-16-12-5-4-9(8-27(16)17)28(12)18(29)10-2-1-3-11(15(10)21)19(22,23)24/h1-3,6-7,9,12H,4-5,8H2/t9-,12+/m0/s1
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n/an/a 1.97E+3n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174775
PNG
(US10053462, 6 | US9102686, 6 | US9540388, 6)
Show SMILES Fc1ccc(cc1)-c1nnc2[C@@H]3CCC[C@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C22H17ClF4N4O/c23-18-15(4-2-5-16(18)22(25,26)27)21(32)31-14-3-1-6-17(31)20-29-28-19(30(20)11-14)12-7-9-13(24)10-8-12/h2,4-5,7-10,14,17H,1,3,6,11H2/t14-,17+/m1/s1
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n/an/a 2.30E+3n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM174775
PNG
(US10053462, 6 | US9102686, 6 | US9540388, 6)
Show SMILES Fc1ccc(cc1)-c1nnc2[C@@H]3CCC[C@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C22H17ClF4N4O/c23-18-15(4-2-5-16(18)22(25,26)27)21(32)31-14-3-1-6-17(31)20-29-28-19(30(20)11-14)12-7-9-13(24)10-8-12/h2,4-5,7-10,14,17H,1,3,6,11H2/t14-,17+/m1/s1
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n/an/a 2.32E+3n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM174829
PNG
(US10053462, 60 | US9102686, 60 | US9540388, 60)
Show SMILES FC(F)(F)c1nccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4ccc(Cl)s4)n2C3)c1Cl
Show InChI InChI=1S/C18H12Cl2F3N5OS/c19-12-4-3-11(30-12)16-26-25-15-10-2-1-8(7-27(15)16)28(10)17(29)9-5-6-24-14(13(9)20)18(21,22)23/h3-6,8,10H,1-2,7H2/t8-,10+/m0/s1
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n/an/a 2.34E+3n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM174799
PNG
(US10053462, 30 | US9102686, 30 | US9540388, 30)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@@H]3CCC[C@H]2c2nnc(-c4ccc(Cl)cn4)n2C3)c1Cl
Show InChI InChI=1S/C21H16Cl2F3N5O/c22-11-7-8-15(27-9-11)18-28-29-19-16-6-1-3-12(10-30(18)19)31(16)20(32)13-4-2-5-14(17(13)23)21(24,25)26/h2,4-5,7-9,12,16H,1,3,6,10H2/t12-,16+/m1/s1
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n/an/a 2.77E+3n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM174817
PNG
(US10053462, 48 | US9102686, 48 | US9540388, 48)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4cccnc4)n2C3)c1Cl
Show InChI InChI=1S/C20H15ClF3N5O/c21-16-13(4-1-5-14(16)20(22,23)24)19(30)29-12-6-7-15(29)18-27-26-17(28(18)10-12)11-3-2-8-25-9-11/h1-5,8-9,12,15H,6-7,10H2/t12-,15+/m0/s1
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n/an/a 2.92E+3n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM174790
PNG
(US10053462, 21 | US9102686, 21 | US9540388, 21)
Show SMILES Fc1cnc(nc1)-c1nnc2[C@@H]3CCC[C@H](Cn12)N3C(=O)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C19H15Cl2FN6O/c20-10-4-5-13(14(21)6-10)19(29)28-12-2-1-3-15(28)17-25-26-18(27(17)9-12)16-23-7-11(22)8-24-16/h4-8,12,15H,1-3,9H2/t12-,15+/m1/s1
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n/an/a 3.35E+3n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174793
PNG
(US10053462, 24 | US9102686, 24 | US9540388, 24)
Show SMILES Cc1cccc(n1)-c1nnc2[C@@H]3CCC[C@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C22H19ClF3N5O/c1-12-5-2-9-16(27-12)19-28-29-20-17-10-3-6-13(11-30(19)20)31(17)21(32)14-7-4-8-15(18(14)23)22(24,25)26/h2,4-5,7-9,13,17H,3,6,10-11H2,1H3/t13-,17+/m1/s1
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n/an/a 3.70E+3n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM174822
PNG
(US10053462, 53 | US9102686, 53 | US9540388, 53)
Show SMILES Cc1c(cccc1C(F)(F)F)C(=O)N1[C@H]2CC[C@@H]1c1nnc(-c3cscn3)n1C2
Show InChI InChI=1S/C19H16F3N5OS/c1-10-12(3-2-4-13(10)19(20,21)22)18(28)27-11-5-6-15(27)17-25-24-16(26(17)7-11)14-8-29-9-23-14/h2-4,8-9,11,15H,5-7H2,1H3/t11-,15+/m0/s1
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n/an/a 3.86E+3n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM174812
PNG
(US10053462, 43 | US9102686, 43 | US9540388, 43)
Show SMILES Fc1ccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4ccccn4)n2C3)c(Cl)c1C(F)(F)F
Show InChI InChI=1S/C20H14ClF4N5O/c21-16-11(5-6-12(22)15(16)20(23,24)25)19(31)30-10-4-7-14(30)18-28-27-17(29(18)9-10)13-3-1-2-8-26-13/h1-3,5-6,8,10,14H,4,7,9H2/t10-,14+/m0/s1
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n/an/a 3.98E+3n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM174820
PNG
(US10053462, 51 | US9102686, 51 | US9540388, 51)
Show SMILES Cc1cc([nH]n1)-c1nnc2[C@H]3CC[C@@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C19H16ClF3N6O/c1-9-7-13(25-24-9)16-26-27-17-14-6-5-10(8-28(16)17)29(14)18(30)11-3-2-4-12(15(11)20)19(21,22)23/h2-4,7,10,14H,5-6,8H2,1H3,(H,24,25)/t10-,14+/m0/s1
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n/an/a 4.10E+3n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174780
PNG
(US10053462, 11 | US9102686, 11 | US9540388, 11)
Show SMILES Fc1ccc(nc1)-c1nnc2[C@H]3CCC[C@@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C21H16ClF4N5O/c22-17-13(4-2-5-14(17)21(24,25)26)20(32)31-12-3-1-6-16(31)19-29-28-18(30(19)10-12)15-8-7-11(23)9-27-15/h2,4-5,7-9,12,16H,1,3,6,10H2/t12-,16+/m0/s1
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n/an/a 5.69E+3n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM174825
PNG
(US10053462, 56 | US9102686, 56 | US9540388, 56)
Show SMILES Cc1nc(cs1)-c1nnc2[C@H]3CC[C@@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C19H15ClF3N5OS/c1-9-24-13(8-30-9)16-25-26-17-14-6-5-10(7-27(16)17)28(14)18(29)11-3-2-4-12(15(11)20)19(21,22)23/h2-4,8,10,14H,5-7H2,1H3/t10-,14+/m0/s1
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n/an/a 5.97E+3n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM174819
PNG
(US10053462, 50 | US9102686, 50 | US9540388, 50)
Show SMILES Fc1cnc(nc1)-c1nnc2[C@H]3CC[C@@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C19H13ClF4N6O/c20-14-11(2-1-3-12(14)19(22,23)24)18(31)30-10-4-5-13(30)16-27-28-17(29(16)8-10)15-25-6-9(21)7-26-15/h1-3,6-7,10,13H,4-5,8H2/t10-,13+/m0/s1
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n/an/a 6.78E+3n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM174813
PNG
(US10053462, 44 | US9102686, 44 | US9540388, 44)
Show SMILES Cc1c(cccc1C(F)(F)F)C(=O)N1[C@H]2CC[C@@H]1c1nnc(-c3ccccn3)n1C2
Show InChI InChI=1S/C21H18F3N5O/c1-12-14(5-4-6-15(12)21(22,23)24)20(30)29-13-8-9-17(29)19-27-26-18(28(19)11-13)16-7-2-3-10-25-16/h2-7,10,13,17H,8-9,11H2,1H3/t13-,17+/m0/s1
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n/an/a 8.49E+3n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM174823
PNG
(US10053462, 54 | US9102686, 54 | US9540388, 54)
Show SMILES Fc1c(Cl)ccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4cscn4)n2C3)c1Cl
Show InChI InChI=1S/C17H12Cl2FN5OS/c18-10-3-2-9(13(19)14(10)20)17(26)25-8-1-4-12(25)16-23-22-15(24(16)5-8)11-6-27-7-21-11/h2-3,6-8,12H,1,4-5H2/t8-,12+/m0/s1
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n/an/a 8.91E+3n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM174826
PNG
(US10053462, 57 | US9102686, 57 | US9540388, 57)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4cncs4)n2C3)c1Cl
Show InChI InChI=1S/C18H13ClF3N5OS/c19-14-10(2-1-3-11(14)18(20,21)22)17(28)27-9-4-5-12(27)15-24-25-16(26(15)7-9)13-6-23-8-29-13/h1-3,6,8-9,12H,4-5,7H2/t9-,12+/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM174831
PNG
(US10053462, 62 | US9102686, 62 | US9540388, 62)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4ccc[nH]4)n2C3)c1Cl
Show InChI InChI=1S/C19H15ClF3N5O/c20-15-11(3-1-4-12(15)19(21,22)23)18(29)28-10-6-7-14(28)17-26-25-16(27(17)9-10)13-5-2-8-24-13/h1-5,8,10,14,24H,6-7,9H2/t10-,14+/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM174830
PNG
(US10053462, 61 | US9102686, 61 | US9540388, 61)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4cccs4)n2C3)c1Cl
Show InChI InChI=1S/C19H14ClF3N4OS/c20-15-11(3-1-4-12(15)19(21,22)23)18(28)27-10-6-7-13(27)16-24-25-17(26(16)9-10)14-5-2-8-29-14/h1-5,8,10,13H,6-7,9H2/t10-,13+/m0/s1
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n/an/a 1.00E+4n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174771
PNG
(US10053462, 2 | US9102686, 2 | US9540388, 2)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CCC[C@@H]2c2nnc(-c4ncccn4)n2C3)c1Cl
Show InChI InChI=1S/C20H16ClF3N6O/c21-15-12(5-2-6-13(15)20(22,23)24)19(31)30-11-4-1-7-14(30)17-27-28-18(29(17)10-11)16-25-8-3-9-26-16/h2-3,5-6,8-9,11,14H,1,4,7,10H2/t11-,14+/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM174809
PNG
(US10053462, 40 | US9102686, 40 | US9540388, 40)
Show SMILES Fc1ccc(cc1)-c1nnc2[C@H]3CC[C@@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C21H15ClF4N4O/c22-17-14(2-1-3-15(17)21(24,25)26)20(31)30-13-8-9-16(30)19-28-27-18(29(19)10-13)11-4-6-12(23)7-5-11/h1-7,13,16H,8-10H2/t13-,16+/m0/s1
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n/an/a 1.00E+4n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM203316
PNG
((6r,10s)-11-{[2-chloro-3-(trifluoromethyl)phenyl]c...)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CCC[C@@H]2c2nnc(-c4cccnn4)n2C3)c1Cl
Show InChI InChI=1S/C20H16ClF3N6O/c21-16-12(5-2-6-13(16)20(22,23)24)19(31)30-11-4-1-8-15(30)18-28-27-17(29(18)10-11)14-7-3-9-25-26-14/h2-3,5-7,9,11,15H,1,4,8,10H2/t11-,15+/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM174828
PNG
(US10053462, 59 | US9102686, 59 | US9540388, 59)
Show SMILES Cc1ncsc1-c1nnc2[C@H]3CC[C@@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C19H15ClF3N5OS/c1-9-15(30-8-24-9)17-26-25-16-13-6-5-10(7-27(16)17)28(13)18(29)11-3-2-4-12(14(11)20)19(21,22)23/h2-4,8,10,13H,5-7H2,1H3/t10-,13+/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM174771
PNG
(US10053462, 2 | US9102686, 2 | US9540388, 2)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CCC[C@@H]2c2nnc(-c4ncccn4)n2C3)c1Cl
Show InChI InChI=1S/C20H16ClF3N6O/c21-15-12(5-2-6-13(15)20(22,23)24)19(31)30-11-4-1-7-14(30)17-27-28-18(29(17)10-11)16-25-8-3-9-26-16/h2-3,5-6,8-9,11,14H,1,4,7,10H2/t11-,14+/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM174793
PNG
(US10053462, 24 | US9102686, 24 | US9540388, 24)
Show SMILES Cc1cccc(n1)-c1nnc2[C@@H]3CCC[C@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C22H19ClF3N5O/c1-12-5-2-9-16(27-12)19-28-29-20-17-10-3-6-13(11-30(19)20)31(17)21(32)14-7-4-8-15(18(14)23)22(24,25)26/h2,4-5,7-9,13,17H,3,6,10-11H2,1H3/t13-,17+/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM174780
PNG
(US10053462, 11 | US9102686, 11 | US9540388, 11)
Show SMILES Fc1ccc(nc1)-c1nnc2[C@H]3CCC[C@@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C21H16ClF4N5O/c22-17-13(4-2-5-14(17)21(24,25)26)20(32)31-12-3-1-6-16(31)19-29-28-18(30(19)10-12)15-8-7-11(23)9-27-15/h2,4-5,7-9,12,16H,1,3,6,10H2/t12-,16+/m0/s1
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n/an/a 1.48E+4n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM174814
PNG
(US10053462, 45 | US9102686, 45 | US9540388, 45)
Show SMILES Fc1ccc(nc1)-c1nnc2[C@H]3CC[C@@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C20H14ClF4N5O/c21-16-12(2-1-3-13(16)20(23,24)25)19(31)30-11-5-7-15(30)18-28-27-17(29(18)9-11)14-6-4-10(22)8-26-14/h1-4,6,8,11,15H,5,7,9H2/t11-,15+/m0/s1
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n/an/a 1.58E+4n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%