BindingDB logo
myBDB logout

Patent code US10053465

Compile Data Set for Download or QSAR

Found 286 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM246874
PNG
(US10053465, 13 | {trans-3-(4-{[4- {[(2R)-2- (hydro...)
Show SMILES OC[C@H]1CCCN1Cc1cc(OC2CCN(CC2)[C@H]2C[C@@](CC#N)(C2)n2cc(cn2)-c2ncnc3[nH]ccc23)nc(c1)C(F)(F)F
Show InChI InChI=1S/C32H36F3N9O2/c33-32(34,35)27-12-21(17-43-9-1-2-23(43)19-45)13-28(41-27)46-25-4-10-42(11-5-25)24-14-31(15-24,6-7-36)44-18-22(16-40-44)29-26-3-8-37-30(26)39-20-38-29/h3,8,12-13,16,18,20,23-25,45H,1-2,4-6,9-11,14-15,17,19H2,(H,37,38,39)/t23-,24-,31-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
As used herein, a selective JAK1 inhibitor is an inhibitor of JAK1 which is selective for JAK1 over JAK2, JAK3 and TYK2. In some embodiments, the com...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM246869
PNG
(4-{3-(Cyanomethyl)- 3-[4-(7H-pyrrolo[2,3- d]pyrimi...)
Show SMILES Fc1ccc(NC(=O)N2CCC(CC2)N2CC(CC#N)(C2)n2cc(cn2)-c2ncnc3[nH]ccc23)c(c1)C(F)(F)F
Show InChI InChI=1S/C27H25F4N9O/c28-18-1-2-22(21(11-18)27(29,30)31)37-25(41)38-9-4-19(5-10-38)39-14-26(15-39,6-7-32)40-13-17(12-36-40)23-20-3-8-33-24(20)35-16-34-23/h1-3,8,11-13,16,19H,4-6,9-10,14-15H2,(H,37,41)(H,33,34,35)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
As used herein, a selective JAK1 inhibitor is an inhibitor of JAK1 which is selective for JAK1 over JAK2, JAK3 and TYK2. In some embodiments, the com...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM246864
PNG
(3-(1- [1,3]oxazolo[5,4- b]pyridin-2- ylpyrrolidin-...)
Show SMILES N#CCC(C1CCN(C1)c1nc2cccnc2o1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C22H19N9O/c23-6-3-18(14-5-9-30(11-14)22-29-17-2-1-7-25-21(17)32-22)31-12-15(10-28-31)19-16-4-8-24-20(16)27-13-26-19/h1-2,4,7-8,10,12-14,18H,3,5,9,11H2,(H,24,26,27)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
As used herein, a selective JAK1 inhibitor is an inhibitor of JAK1 which is selective for JAK1 over JAK2, JAK3 and TYK2. In some embodiments, the com...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM246885
PNG
(US10053465, 24 | {trans-3-(4-{[4- ({[(2R)-2- hydro...)
Show SMILES C[C@@H](O)CNCc1cc(OC2CCN(CC2)[C@H]2C[C@@](CC#N)(C2)n2cc(cn2)-c2ncnc3[nH]ccc23)nc(c1)C(F)(F)F
Show InChI InChI=1S/C30H34F3N9O2/c1-19(43)14-35-15-20-10-25(30(31,32)33)40-26(11-20)44-23-3-8-41(9-4-23)22-12-29(13-22,5-6-34)42-17-21(16-39-42)27-24-2-7-36-28(24)38-18-37-27/h2,7,10-11,16-19,22-23,35,43H,3-5,8-9,12-15H2,1H3,(H,36,37,38)/t19-,22-,29-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
As used herein, a selective JAK1 inhibitor is an inhibitor of JAK1 which is selective for JAK1 over JAK2, JAK3 and TYK2. In some embodiments, the com...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM246861
PNG
(3-[1-(6- chloropyridin-2- yl)pyrrolidin-3-yl]-3- [...)
Show SMILES Clc1cccc(n1)N1CCC(C1)C(CC#N)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C21H19ClN8/c22-18-2-1-3-19(28-18)29-9-6-14(11-29)17(4-7-23)30-12-15(10-27-30)20-16-5-8-24-21(16)26-13-25-20/h1-3,5,8,10,12-14,17H,4,6,9,11H2,(H,24,25,26)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
As used herein, a selective JAK1 inhibitor is an inhibitor of JAK1 which is selective for JAK1 over JAK2, JAK3 and TYK2. In some embodiments, the com...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM246875
PNG
(4-(4-{3- [(dimethylamino) methyl]-5- fluorophenoxy...)
Show SMILES CN(C)Cc1cc(F)cc(OC2CCN(CC(CC#N)n3cc(cn3)-c3ncnc4[nH]ccc34)CC2)c1
Show InChI InChI=1S/C27H31FN8O/c1-34(2)15-19-11-21(28)13-24(12-19)37-23-5-9-35(10-6-23)17-22(3-7-29)36-16-20(14-33-36)26-25-4-8-30-27(25)32-18-31-26/h4,8,11-14,16,18,22-23H,3,5-6,9-10,15,17H2,1-2H3,(H,30,31,32)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
As used herein, a selective JAK1 inhibitor is an inhibitor of JAK1 which is selective for JAK1 over JAK2, JAK3 and TYK2. In some embodiments, the com...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM246876
PNG
(5-{3-(cyanomethyl)- 3-[4-(7H-pyrrolo[2,3- d]pyrimi...)
Show SMILES CC(C)NC(=O)c1cnc(cn1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C22H22N10O/c1-14(2)30-21(33)17-8-26-18(9-25-17)31-11-22(12-31,4-5-23)32-10-15(7-29-32)19-16-3-6-24-20(16)28-13-27-19/h3,6-10,13-14H,4,11-12H2,1-2H3,(H,30,33)(H,24,27,28)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
As used herein, a selective JAK1 inhibitor is an inhibitor of JAK1 which is selective for JAK1 over JAK2, JAK3 and TYK2. In some embodiments, the com...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM246883
PNG
(US10053465, 22 | {1-(cis-4-{[4-{[(3S)- 3-hydroxypy...)
Show SMILES O[C@H]1CCN(Cc2cc(O[C@H]3CC[C@H](CC3)N3CC(CC#N)(C3)n3cc(cn3)-c3ncnc4[nH]ccc34)nc(c2)C(F)(F)F)C1
Show InChI InChI=1S/C31H34F3N9O2/c32-31(33,34)26-11-20(14-41-10-6-23(44)16-41)12-27(40-26)45-24-3-1-22(2-4-24)42-17-30(18-42,7-8-35)43-15-21(13-39-43)28-25-5-9-36-29(25)38-19-37-28/h5,9,11-13,15,19,22-24,44H,1-4,6-7,10,14,16-18H2,(H,36,37,38)/t22-,23-,24+/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
As used herein, a selective JAK1 inhibitor is an inhibitor of JAK1 which is selective for JAK1 over JAK2, JAK3 and TYK2. In some embodiments, the com...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM246871
PNG
(US10053465, 10 | [trans-1-[4-(7H- pyrrolo[2,3- d]p...)
Show SMILES FC(F)(F)c1nccc(n1)C(=O)N1CCN(CC1)[C@H]1C[C@@](CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C25H23F3N10O/c26-25(27,28)23-31-6-2-19(35-23)22(39)37-9-7-36(8-10-37)17-11-24(12-17,3-4-29)38-14-16(13-34-38)20-18-1-5-30-21(18)33-15-32-20/h1-2,5-6,13-15,17H,3,7-12H2,(H,30,32,33)/t17-,24-
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
As used herein, a selective JAK1 inhibitor is an inhibitor of JAK1 which is selective for JAK1 over JAK2, JAK3 and TYK2. In some embodiments, the com...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM246876
PNG
(5-{3-(cyanomethyl)- 3-[4-(7H-pyrrolo[2,3- d]pyrimi...)
Show SMILES CC(C)NC(=O)c1cnc(cn1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C22H22N10O/c1-14(2)30-21(33)17-8-26-18(9-25-17)31-11-22(12-31,4-5-23)32-10-15(7-29-32)19-16-3-6-24-20(16)28-13-27-19/h3,6-10,13-14H,4,11-12H2,1-2H3,(H,30,33)(H,24,27,28)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
As used herein, a selective JAK1 inhibitor is an inhibitor of JAK1 which is selective for JAK1 over JAK2, JAK3 and TYK2. In some embodiments, the com...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM246880
PNG
(US10053465, 19 | {1-(cis-4-{[4- [(ethylamino) meth...)
Show SMILES CCNCc1cc(O[C@H]2CC[C@H](CC2)N2CC(CC#N)(C2)n2cc(cn2)-c2ncnc3[nH]ccc23)nc(c1)C(F)(F)F
Show InChI InChI=1S/C29H32F3N9O/c1-2-34-13-19-11-24(29(30,31)32)39-25(12-19)42-22-5-3-21(4-6-22)40-16-28(17-40,8-9-33)41-15-20(14-38-41)26-23-7-10-35-27(23)37-18-36-26/h7,10-12,14-15,18,21-22,34H,2-6,8,13,16-17H2,1H3,(H,35,36,37)/t21-,22+
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
As used herein, a selective JAK1 inhibitor is an inhibitor of JAK1 which is selective for JAK1 over JAK2, JAK3 and TYK2. In some embodiments, the com...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM246882
PNG
(US10053465, 21 | {1-(cis-4-{[4-{[(3R)- 3-hydroxypy...)
Show SMILES O[C@@H]1CCN(Cc2cc(O[C@H]3CC[C@H](CC3)N3CC(CC#N)(C3)n3cc(cn3)-c3ncnc4[nH]ccc34)nc(c2)C(F)(F)F)C1
Show InChI InChI=1S/C31H34F3N9O2/c32-31(33,34)26-11-20(14-41-10-6-23(44)16-41)12-27(40-26)45-24-3-1-22(2-4-24)42-17-30(18-42,7-8-35)43-15-21(13-39-43)28-25-5-9-36-29(25)38-19-37-28/h5,9,11-13,15,19,22-24,44H,1-4,6-7,10,14,16-18H2,(H,36,37,38)/t22-,23-,24+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
As used herein, a selective JAK1 inhibitor is an inhibitor of JAK1 which is selective for JAK1 over JAK2, JAK3 and TYK2. In some embodiments, the com...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM246881
PNG
(US10053465, 20 | {1-(cis-4-{[4-(1- hydroxy-1- meth...)
Show SMILES CC(C)(O)c1cc(O[C@H]2CC[C@H](CC2)N2CC(CC#N)(C2)n2cc(cn2)-c2ncnc3[nH]ccc23)nc(c1)C(F)(F)F
Show InChI InChI=1S/C29H31F3N8O2/c1-27(2,41)19-11-23(29(30,31)32)38-24(12-19)42-21-5-3-20(4-6-21)39-15-28(16-39,8-9-33)40-14-18(13-37-40)25-22-7-10-34-26(22)36-17-35-25/h7,10-14,17,20-21,41H,3-6,8,15-16H2,1-2H3,(H,34,35,36)/t20-,21+
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
As used herein, a selective JAK1 inhibitor is an inhibitor of JAK1 which is selective for JAK1 over JAK2, JAK3 and TYK2. In some embodiments, the com...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM246866
PNG
(4-[(4-{3-cyano-2-[4- (7H-pyrrolo[2,3- d]pyrimidin-...)
Show SMILES Fc1cc(ccc1C(=O)N1CCN(CC(CC#N)n2cc(cn2)-c2ncnc3[nH]ccc23)CC1)[N+]#[C-]
Show InChI InChI=1S/C25H22FN9O/c1-28-18-2-3-20(22(26)12-18)25(36)34-10-8-33(9-11-34)15-19(4-6-27)35-14-17(13-32-35)23-21-5-7-29-24(21)31-16-30-23/h2-3,5,7,12-14,16,19H,4,8-11,15H2,(H,29,30,31)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
As used herein, a selective JAK1 inhibitor is an inhibitor of JAK1 which is selective for JAK1 over JAK2, JAK3 and TYK2. In some embodiments, the com...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM246886
PNG
(US10053465, 25 | {trans-5-3-(4-{[4- ({[(2S)-2- hyd...)
Show SMILES C[C@H](O)CNCc1cc(OC2CCN(CC2)[C@H]2C[C@@](CC#N)(C2)n2cc(cn2)-c2ncnc3[nH]ccc23)nc(c1)C(F)(F)F
Show InChI InChI=1S/C30H34F3N9O2/c1-19(43)14-35-15-20-10-25(30(31,32)33)40-26(11-20)44-23-3-8-41(9-4-23)22-12-29(13-22,5-6-34)42-17-21(16-39-42)27-24-2-7-36-28(24)38-18-37-27/h2,7,10-11,16-19,22-23,35,43H,3-5,8-9,12-15H2,1H3,(H,36,37,38)/t19-,22-,29-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
As used herein, a selective JAK1 inhibitor is an inhibitor of JAK1 which is selective for JAK1 over JAK2, JAK3 and TYK2. In some embodiments, the com...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM246870
PNG
(US10053465, 9 | [3-[4-(7H- pyrrolo[2,3- d]pyrimidi...)
Show SMILES FC(F)(F)c1nccc(n1)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C25H23F3N10O/c26-25(27,28)23-31-8-2-19(35-23)22(39)36-9-3-17(4-10-36)37-13-24(14-37,5-6-29)38-12-16(11-34-38)20-18-1-7-30-21(18)33-15-32-20/h1-2,7-8,11-12,15,17H,3-5,9-10,13-14H2,(H,30,32,33)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
As used herein, a selective JAK1 inhibitor is an inhibitor of JAK1 which is selective for JAK1 over JAK2, JAK3 and TYK2. In some embodiments, the com...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM246877
PNG
(4-{3-(cyanomethyl)- 3-[4-(7H-pyrrolo[2,3- d]pyrimi...)
Show SMILES C[C@H](NC(=O)c1cc(F)c(cc1F)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12)C(F)(F)F
Show InChI InChI=1S/C24H19F5N8O/c1-13(24(27,28)29)35-22(38)16-6-18(26)19(7-17(16)25)36-10-23(11-36,3-4-30)37-9-14(8-34-37)20-15-2-5-31-21(15)33-12-32-20/h2,5-9,12-13H,3,10-11H2,1H3,(H,35,38)(H,31,32,33)/t13-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
As used herein, a selective JAK1 inhibitor is an inhibitor of JAK1 which is selective for JAK1 over JAK2, JAK3 and TYK2. In some embodiments, the com...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM246868
PNG
(US10053465, 7 | {1-{1-[3-Fluoro-2- (trifluoromethy...)
Show SMILES Fc1c(ccnc1C(F)(F)F)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C26H23F4N9O/c27-20-18(1-7-32-22(20)26(28,29)30)24(40)37-9-3-17(4-10-37)38-13-25(14-38,5-6-31)39-12-16(11-36-39)21-19-2-8-33-23(19)35-15-34-21/h1-2,7-8,11-12,15,17H,3-5,9-10,13-14H2,(H,33,34,35)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
As used herein, a selective JAK1 inhibitor is an inhibitor of JAK1 which is selective for JAK1 over JAK2, JAK3 and TYK2. In some embodiments, the com...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM246872
PNG
(US10053465, 11 | {trans-3-(4-{[4-[(3- hydroxyazeti...)
Show SMILES OC1CN(Cc2cc(OC3CCN(CC3)[C@H]3C[C@@](CC#N)(C3)n3cc(cn3)-c3ncnc4[nH]ccc34)nc(c2)C(F)(F)F)C1
Show InChI InChI=1S/C30H32F3N9O2/c31-30(32,33)25-9-19(14-40-16-22(43)17-40)10-26(39-25)44-23-2-7-41(8-3-23)21-11-29(12-21,4-5-34)42-15-20(13-38-42)27-24-1-6-35-28(24)37-18-36-27/h1,6,9-10,13,15,18,21-23,43H,2-4,7-8,11-12,14,16-17H2,(H,35,36,37)/t21-,29-
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
As used herein, a selective JAK1 inhibitor is an inhibitor of JAK1 which is selective for JAK1 over JAK2, JAK3 and TYK2. In some embodiments, the com...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM246879
PNG
(US10053465, 18 | {1-(cis-4-{[6-(2- hydroxyethyl)-2...)
Show SMILES OCCc1cc(O[C@H]2CC[C@H](CC2)N2CC(CC#N)(C2)n2cc(cn2)-c2ncnc3[nH]ccc23)nc(n1)C(F)(F)F
Show InChI InChI=1S/C27H28F3N9O2/c28-27(29,30)25-36-18(6-10-40)11-22(37-25)41-20-3-1-19(2-4-20)38-14-26(15-38,7-8-31)39-13-17(12-35-39)23-21-5-9-32-24(21)34-16-33-23/h5,9,11-13,16,19-20,40H,1-4,6-7,10,14-15H2,(H,32,33,34)/t19-,20+
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
As used herein, a selective JAK1 inhibitor is an inhibitor of JAK1 which is selective for JAK1 over JAK2, JAK3 and TYK2. In some embodiments, the com...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM246888
PNG
(US10053465, 26 | trans-3-(4-{[4-(2- hydroxyethyl)-...)
Show SMILES OCCc1cc(OC2CCN(CC2)[C@H]2C[C@@](CC#N)(C2)n2cc(cn2)-c2ncnc3[nH]ccc23)nc(c1)C(F)(F)F
Show InChI InChI=1S/C28H29F3N8O2/c29-28(30,31)23-11-18(4-10-40)12-24(37-23)41-21-2-8-38(9-3-21)20-13-27(14-20,5-6-32)39-16-19(15-36-39)25-22-1-7-33-26(22)35-17-34-25/h1,7,11-12,15-17,20-21,40H,2-5,8-10,13-14H2,(H,33,34,35)/t20-,27-
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
As used herein, a selective JAK1 inhibitor is an inhibitor of JAK1 which is selective for JAK1 over JAK2, JAK3 and TYK2. In some embodiments, the com...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM246884
PNG
(US10053465, 23 | {trans-3-(4-{[4- ({[(1S)-2-hydrox...)
Show SMILES C[C@@H](CO)NCc1cc(OC2CCN(CC2)[C@H]2C[C@@](CC#N)(C2)n2cc(cn2)-c2ncnc3[nH]ccc23)nc(c1)C(F)(F)F
Show InChI InChI=1S/C30H34F3N9O2/c1-19(17-43)36-14-20-10-25(30(31,32)33)40-26(11-20)44-23-3-8-41(9-4-23)22-12-29(13-22,5-6-34)42-16-21(15-39-42)27-24-2-7-35-28(24)38-18-37-27/h2,7,10-11,15-16,18-19,22-23,36,43H,3-5,8-9,12-14,17H2,1H3,(H,35,37,38)/t19-,22-,29-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
As used herein, a selective JAK1 inhibitor is an inhibitor of JAK1 which is selective for JAK1 over JAK2, JAK3 and TYK2. In some embodiments, the com...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM246867
PNG
(4-[(4-{3-cyano-2-[3- (7H-pyrrolo[2,3- d]pyrimidin-...)
Show SMILES Fc1cc(ccc1C(=O)N1CCN(CC(CC#N)n2ccc(c2)-c2ncnc3[nH]ccc23)CC1)C#N
Show InChI InChI=1S/C26H23FN8O/c27-23-13-18(14-29)1-2-21(23)26(36)34-11-9-33(10-12-34)16-20(3-6-28)35-8-5-19(15-35)24-22-4-7-30-25(22)32-17-31-24/h1-2,4-5,7-8,13,15,17,20H,3,9-12,16H2,(H,30,31,32)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
As used herein, a selective JAK1 inhibitor is an inhibitor of JAK1 which is selective for JAK1 over JAK2, JAK3 and TYK2. In some embodiments, the com...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM246873
PNG
(US10053465, 12 | {trans-3-(4-{[4- {[(2S)-2- (hydro...)
Show SMILES OC[C@@H]1CCCN1Cc1cc(OC2CCN(CC2)[C@H]2C[C@@](CC#N)(C2)n2cc(cn2)-c2ncnc3[nH]ccc23)nc(c1)C(F)(F)F
Show InChI InChI=1S/C32H36F3N9O2/c33-32(34,35)27-12-21(17-43-9-1-2-23(43)19-45)13-28(41-27)46-25-4-10-42(11-5-25)24-14-31(15-24,6-7-36)44-18-22(16-40-44)29-26-3-8-37-30(26)39-20-38-29/h3,8,12-13,16,18,20,23-25,45H,1-2,4-6,9-11,14-15,17,19H2,(H,37,38,39)/t23-,24-,31-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
As used herein, a selective JAK1 inhibitor is an inhibitor of JAK1 which is selective for JAK1 over JAK2, JAK3 and TYK2. In some embodiments, the com...


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM246897
PNG
(1-Methyl-N-({2-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl...)
Show SMILES Cn1nccc1C(=O)NCC1(Cc2ccccc2C1)c1cccc(c1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C27H24N6O/c1-33-23(10-12-32-33)26(34)29-16-27(14-19-5-2-3-6-20(19)15-27)21-8-4-7-18(13-21)24-22-9-11-28-25(22)31-17-30-24/h2-13,17H,14-16H2,1H3,(H,29,34)(H,28,30,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<50n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
In some embodiments, the PI3Kδ inhibitor is selective. By ┐selective┐ is meant that the compound binds to or inhibits a kinase with greater aff...


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM50004547
PNG
(CHEMBL2216863 | US9708333, 28)
Show SMILES C[C@H](Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cccc(F)c1
Show InChI InChI=1S/C20H16FN7OS/c1-10-7-30-20-27-15(11(2)26-18-16-17(23-8-22-16)24-9-25-18)14(19(29)28(10)20)12-4-3-5-13(21)6-12/h3-9,11H,1-2H3,(H2,22,23,24,25,26)/t11-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

US Patent
n/an/a<50n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
In some embodiments, the PI3Kδ inhibitor is selective. By ┐selective┐ is meant that the compound binds to or inhibits a kinase with greater aff...


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM246892
PNG
(4-[1-(4-amino-3-methyl- 1H-pyrazolo[3,4- d]pyrimid...)
Show SMILES COc1c(cc(Cl)c([N+]#[C-])c1C1CN(CCO)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C21H24ClN7O2/c1-11-16-20(23)25-10-26-21(16)29(27-11)12(2)14-7-15(22)18(24-3)17(19(14)31-4)13-8-28(9-13)5-6-30/h7,10,12-13,30H,5-6,8-9H2,1-2,4H3,(H2,23,25,26)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<50n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
In some embodiments, the PI3Kδ inhibitor is selective. By ┐selective┐ is meant that the compound binds to or inhibits a kinase with greater aff...


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM246891
PNG
(4-[1-(4-amino-3-methyl- 1H-pyrazolo[3,4- d]pyrimid...)
Show SMILES COc1c(cc(Cl)c([N+]#[C-])c1C1CN(C[C@H](C)O)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H26ClN7O2/c1-11(31)7-29-8-14(9-29)18-19(25-4)16(23)6-15(20(18)32-5)13(3)30-22-17(12(2)28-30)21(24)26-10-27-22/h6,10-11,13-14,31H,7-9H2,1-3,5H3,(H2,24,26,27)/t11-,13?/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<50n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
In some embodiments, the PI3Kδ inhibitor is selective. By ┐selective┐ is meant that the compound binds to or inhibits a kinase with greater aff...


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM50004539
PNG
(CHEMBL2216867 | US9708333, 33)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1cc(Cl)c2ccnnc2c1-c1cccc(F)c1
Show InChI InChI=1S/C21H15ClFN7/c1-11(29-21-19-20(25-9-24-19)26-10-27-21)15-8-16(22)14-5-6-28-30-18(14)17(15)12-3-2-4-13(23)7-12/h2-11H,1H3,(H2,24,25,26,27,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
US Patent
n/an/a<50n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
In some embodiments, the PI3Kδ inhibitor is selective. By ┐selective┐ is meant that the compound binds to or inhibits a kinase with greater aff...


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM246893
PNG
(5-{3-[1-(4-amino-3- methyl-1H-pyrazolo[3,4 d]pyrim...)
Show SMILES CCOc1c(cc(C)c(C#N)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C26H28N8O2/c1-7-36-23-18(16(4)34-25-21(15(3)32-34)24(28)30-13-31-25)10-14(2)19(11-27)22(23)17-8-9-20(29-12-17)26(35)33(5)6/h8-10,12-13,16H,7H2,1-6H3,(H2,28,30,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<50n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
In some embodiments, the PI3Kδ inhibitor is selective. By ┐selective┐ is meant that the compound binds to or inhibits a kinase with greater aff...


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM246889
PNG
(7-(1-(9H-purin-6- ylamino)ethyl)-6-(3- fluoropheny...)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cccc(F)c1
Show InChI InChI=1S/C20H16FN7OS/c1-10-7-30-20-27-15(11(2)26-18-16-17(23-8-22-16)24-9-25-18)14(19(29)28(10)20)12-4-3-5-13(21)6-12/h3-9,11H,1-2H3,(H2,22,23,24,25,26)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<50n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
In some embodiments, the PI3Kδ inhibitor is selective. By ┐selective┐ is meant that the compound binds to or inhibits a kinase with greater aff...


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM246896
PNG
(4-chloro-3'-fluoro-3- methyl-6-[1-(9H-purin-6-...)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1cc(Cl)c(C)c(C#N)c1-c1cccc(F)c1
Show InChI InChI=1S/C21H16ClFN6/c1-11-16(8-24)18(13-4-3-5-14(23)6-13)15(7-17(11)22)12(2)29-21-19-20(26-9-25-19)27-10-28-21/h3-7,9-10,12H,1-2H3,(H2,25,26,27,28,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 75n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
In some embodiments, the PI3Kδ inhibitor is selective. By ┐selective┐ is meant that the compound binds to or inhibits a kinase with greater aff...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM246852
PNG
(((2R,5S)-5-{2-[(1R)- 1-hydroxyethyl]-1H- imidazo[4...)
Show SMILES C[C@@H](O)c1nc2cnc3ccsc3c2n1[C@H]1CC[C@H](CC#N)OC1
Show InChI InChI=1S/C17H18N4O2S/c1-10(22)17-20-14-8-19-13-5-7-24-16(13)15(14)21(17)11-2-3-12(4-6-18)23-9-11/h5,7-8,10-12,22H,2-4,9H2,1H3/t10-,11+,12-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
As used herein, a selective JAK1 inhibitor is an inhibitor of JAK1 which is selective for JAK1 over JAK2, JAK3 and TYK2. In some embodiments, the com...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM246853
PNG
(4-[3-(cyanomethyl)- 3-(3',5'-dimethyl- 1H,...)
Show SMILES C[C@H](NC(=O)c1cc(F)c(cc1F)N1CC(CC#N)(C1)n1cc(cn1)-c1c(C)n[nH]c1C)C(F)(F)F
Show InChI InChI=1S/C23H22F5N7O/c1-12-20(13(2)33-32-12)15-8-30-35(9-15)22(4-5-29)10-34(11-22)19-7-17(24)16(6-18(19)25)21(36)31-14(3)23(26,27)28/h6-9,14H,4,10-11H2,1-3H3,(H,31,36)(H,32,33)/t14-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<300n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
As used herein, a selective JAK1 inhibitor is an inhibitor of JAK1 which is selective for JAK1 over JAK2, JAK3 and TYK2. In some embodiments, the com...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM246879
PNG
(US10053465, 18 | {1-(cis-4-{[6-(2- hydroxyethyl)-2...)
Show SMILES OCCc1cc(O[C@H]2CC[C@H](CC2)N2CC(CC#N)(C2)n2cc(cn2)-c2ncnc3[nH]ccc23)nc(n1)C(F)(F)F
Show InChI InChI=1S/C27H28F3N9O2/c28-27(29,30)25-36-18(6-10-40)11-22(37-25)41-20-3-1-19(2-4-20)38-14-26(15-38,7-8-31)39-13-17(12-35-39)23-21-5-9-32-24(21)34-16-33-23/h5,9,11-13,16,19-20,40H,1-4,6-7,10,14-15H2,(H,32,33,34)/t19-,20+
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM246985
PNG
(4-{2-[2-(Aminomethyl)-2,3-dihydro-1H-inden-2-yl]py...)
Show SMILES NCC1(Cc2ccccc2C1)c1cc(ccn1)-c1nc(Nc2cccc(CN3CCOCC3)c2)nc2[nH]ccc12
Show InChI InChI=1S/C32H33N7O/c33-21-32(18-24-5-1-2-6-25(24)19-32)28-17-23(8-10-34-28)29-27-9-11-35-30(27)38-31(37-29)36-26-7-3-4-22(16-26)20-39-12-14-40-15-13-39/h1-11,16-17H,12-15,18-21,33H2,(H2,35,36,37,38)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM246990
PNG
(1-{2-[3-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-1...)
Show SMILES NCC1(CCc2ccccc2C1)c1cccc(c1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C23H22N4/c24-14-23(10-8-16-4-1-2-5-18(16)13-23)19-7-3-6-17(12-19)21-20-9-11-25-22(20)27-15-26-21/h1-7,9,11-12,15H,8,10,13-14,24H2,(H,25,26,27)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


Citation and Details
More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens)
BDBM246852
PNG
(((2R,5S)-5-{2-[(1R)- 1-hydroxyethyl]-1H- imidazo[4...)
Show SMILES C[C@@H](O)c1nc2cnc3ccsc3c2n1[C@H]1CC[C@H](CC#N)OC1
Show InChI InChI=1S/C17H18N4O2S/c1-10(22)17-20-14-8-19-13-5-7-24-16(13)15(14)21(17)11-2-3-12(4-6-18)23-9-11/h5,7-8,10-12,22H,2-4,9H2,1H3/t10-,11+,12-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM246938
PNG
(1-{5-(6-Pyrrolidin-1-ylpyridin-3-yl)-2-[3-(7H-pyrr...)
Show SMILES NCC1(Cc2ccc(cc2C1)-c1ccc(nc1)N1CCCC1)c1cccc(c1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C31H30N6/c32-19-31(26-5-3-4-22(15-26)29-27-10-11-33-30(27)36-20-35-29)16-23-7-6-21(14-25(23)17-31)24-8-9-28(34-18-24)37-12-1-2-13-37/h3-11,14-15,18,20H,1-2,12-13,16-17,19,32H2,(H,33,35,36)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM246883
PNG
(US10053465, 22 | {1-(cis-4-{[4-{[(3S)- 3-hydroxypy...)
Show SMILES O[C@H]1CCN(Cc2cc(O[C@H]3CC[C@H](CC3)N3CC(CC#N)(C3)n3cc(cn3)-c3ncnc4[nH]ccc34)nc(c2)C(F)(F)F)C1
Show InChI InChI=1S/C31H34F3N9O2/c32-31(33,34)26-11-20(14-41-10-6-23(44)16-41)12-27(40-26)45-24-3-1-22(2-4-24)42-17-30(18-42,7-8-35)43-15-21(13-39-43)28-25-5-9-36-29(25)38-19-37-28/h5,9,11-13,15,19,22-24,44H,1-4,6-7,10,14,16-18H2,(H,36,37,38)/t22-,23-,24+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


Citation and Details
More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens)
BDBM246885
PNG
(US10053465, 24 | {trans-3-(4-{[4- ({[(2R)-2- hydro...)
Show SMILES C[C@@H](O)CNCc1cc(OC2CCN(CC2)[C@H]2C[C@@](CC#N)(C2)n2cc(cn2)-c2ncnc3[nH]ccc23)nc(c1)C(F)(F)F
Show InChI InChI=1S/C30H34F3N9O2/c1-19(43)14-35-15-20-10-25(30(31,32)33)40-26(11-20)44-23-3-8-41(9-4-23)22-12-29(13-22,5-6-34)42-17-21(16-39-42)27-24-2-7-36-28(24)38-18-37-27/h2,7,10-11,16-19,22-23,35,43H,3-5,8-9,12-15H2,1H3,(H,36,37,38)/t19-,22-,29-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


Citation and Details
More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens)
BDBM246985
PNG
(4-{2-[2-(Aminomethyl)-2,3-dihydro-1H-inden-2-yl]py...)
Show SMILES NCC1(Cc2ccccc2C1)c1cc(ccn1)-c1nc(Nc2cccc(CN3CCOCC3)c2)nc2[nH]ccc12
Show InChI InChI=1S/C32H33N7O/c33-21-32(18-24-5-1-2-6-25(24)19-32)28-17-23(8-10-34-28)29-27-9-11-35-30(27)38-31(37-29)36-26-7-3-4-22(16-26)20-39-12-14-40-15-13-39/h1-11,16-17H,12-15,18-21,33H2,(H2,35,36,37,38)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM246902
PNG
(N-(2-{2-[3-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)phenyl...)
Show SMILES O=C(NCCC1(Cc2ccccc2C1)c1cccc(c1)-c1ncnc2[nH]ccc12)C1CC1
Show InChI InChI=1S/C27H26N4O/c32-26(18-8-9-18)29-13-11-27(15-20-4-1-2-5-21(20)16-27)22-7-3-6-19(14-22)24-23-10-12-28-25(23)31-17-30-24/h1-7,10,12,14,17-18H,8-9,11,13,15-16H2,(H,29,32)(H,28,30,31)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM246989
PNG
(3-(Aminomethyl)-3-[3-(7H-pyrrolo[2,3-d]pyrimidin-4...)
Show SMILES NC[C@]1(CC(O)c2ccccc12)c1cccc(c1)-c1ncnc2[nH]ncc12
Show InChI InChI=1S/C21H19N5O/c22-11-21(9-18(27)15-6-1-2-7-17(15)21)14-5-3-4-13(8-14)19-16-10-25-26-20(16)24-12-23-19/h1-8,10,12,18,27H,9,11,22H2,(H,23,24,25,26)/t18?,21-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM246889
PNG
(7-(1-(9H-purin-6- ylamino)ethyl)-6-(3- fluoropheny...)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cccc(F)c1
Show InChI InChI=1S/C20H16FN7OS/c1-10-7-30-20-27-15(11(2)26-18-16-17(23-8-22-16)24-9-25-18)14(19(29)28(10)20)12-4-3-5-13(21)6-12/h3-9,11H,1-2H3,(H2,22,23,24,25,26)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM246868
PNG
(US10053465, 7 | {1-{1-[3-Fluoro-2- (trifluoromethy...)
Show SMILES Fc1c(ccnc1C(F)(F)F)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C26H23F4N9O/c27-20-18(1-7-32-22(20)26(28,29)30)24(40)37-9-3-17(4-10-37)38-13-25(14-38,5-6-31)39-12-16(11-36-39)21-19-2-8-33-23(19)35-15-34-21/h1-2,7-8,11-12,15,17H,3-5,9-10,13-14H2,(H,33,34,35)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM246873
PNG
(US10053465, 12 | {trans-3-(4-{[4- {[(2S)-2- (hydro...)
Show SMILES OC[C@@H]1CCCN1Cc1cc(OC2CCN(CC2)[C@H]2C[C@@](CC#N)(C2)n2cc(cn2)-c2ncnc3[nH]ccc23)nc(c1)C(F)(F)F
Show InChI InChI=1S/C32H36F3N9O2/c33-32(34,35)27-12-21(17-43-9-1-2-23(43)19-45)13-28(41-27)46-25-4-10-42(11-5-25)24-14-31(15-24,6-7-36)44-18-22(16-40-44)29-26-3-8-37-30(26)39-20-38-29/h3,8,12-13,16,18,20,23-25,45H,1-2,4-6,9-11,14-15,17,19H2,(H,37,38,39)/t23-,24-,31-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


Citation and Details
More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens)
BDBM246877
PNG
(4-{3-(cyanomethyl)- 3-[4-(7H-pyrrolo[2,3- d]pyrimi...)
Show SMILES C[C@H](NC(=O)c1cc(F)c(cc1F)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12)C(F)(F)F
Show InChI InChI=1S/C24H19F5N8O/c1-13(24(27,28)29)35-22(38)16-6-18(26)19(7-17(16)25)36-10-23(11-36,3-4-30)37-9-14(8-34-37)20-15-2-5-31-21(15)33-12-32-20/h2,5-9,12-13H,3,10-11H2,1H3,(H,35,38)(H,31,32,33)/t13-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM246979
PNG
(4-{3-[2-(Aminomethyl)-2,3-dihydro-1H-inden-2-yl]ph...)
Show SMILES CC(C)Nc1nc(-c2cccc(c2)C2(CN)Cc3ccccc3C2)c2cc[nH]c2n1
Show InChI InChI=1S/C25H27N5/c1-16(2)28-24-29-22(21-10-11-27-23(21)30-24)17-8-5-9-20(12-17)25(15-26)13-18-6-3-4-7-19(18)14-25/h3-12,16H,13-15,26H2,1-2H3,(H2,27,28,29,30)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


Citation and Details
More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens)
BDBM246884
PNG
(US10053465, 23 | {trans-3-(4-{[4- ({[(1S)-2-hydrox...)
Show SMILES C[C@@H](CO)NCc1cc(OC2CCN(CC2)[C@H]2C[C@@](CC#N)(C2)n2cc(cn2)-c2ncnc3[nH]ccc23)nc(c1)C(F)(F)F
Show InChI InChI=1S/C30H34F3N9O2/c1-19(17-43)36-14-20-10-25(30(31,32)33)40-26(11-20)44-23-3-8-41(9-4-23)22-12-29(13-22,5-6-34)42-16-21(15-39-42)27-24-2-7-35-28(24)38-18-37-27/h2,7,10-11,15-16,18-19,22-23,36,43H,3-5,8-9,12-14,17H2,1H3,(H,35,37,38)/t19-,22-,29-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


Citation and Details
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 286 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%