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Patent code US10058550

Compile Data Set for Download or QSAR

Found 788 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Apelin receptor


(Homo sapiens)
BDBM269508
PNG
(US10058550, Example 27.0 | US10058550, Example 549...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C25H29N7O6S/c1-15-13-26-23(27-14-15)22(38-6)16(2)39(33,34)31-25-30-29-24(17-9-7-12-20(28-17)37-5)32(25)21-18(35-3)10-8-11-19(21)36-4/h7-14,16,22H,1-6H3,(H,30,31)/t16-,22-/m0/s1
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n/an/an/an/a 0.190n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269517
PNG
((1R,2S)-1-methoxy-N-(5-(6-methoxy-2-pyridinyl)-4-p...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1ccccc1)c1ncc(C)cn1
Show InChI InChI=1S/C23H25N7O4S/c1-15-13-24-21(25-14-15)20(34-4)16(2)35(31,32)29-23-28-27-22(18-11-8-12-19(26-18)33-3)30(23)17-9-6-5-7-10-17/h5-14,16,20H,1-4H3,(H,28,29)/t16-,20-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269527
PNG
((1R,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(3-pyridinyl)...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccnc2)n1-c1c(OC)cccc1OC)c1cnc(C)cn1
Show InChI InChI=1S/C24H27N7O5S/c1-15-12-27-18(14-26-15)22(36-5)16(2)37(32,33)30-24-29-28-23(17-8-7-11-25-13-17)31(24)21-19(34-3)9-6-10-20(21)35-4/h6-14,16,22H,1-5H3,(H,29,30)/t16-,22-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269529
PNG
((1R,2S)-N-(4-(4-chlorophenyl)-5-(6-methoxy-2-pyrid...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1ccc(Cl)cc1)c1ncc(C)cn1
Show InChI InChI=1S/C23H24ClN7O4S/c1-14-12-25-21(26-13-14)20(35-4)15(2)36(32,33)30-23-29-28-22(18-6-5-7-19(27-18)34-3)31(23)17-10-8-16(24)9-11-17/h5-13,15,20H,1-4H3,(H,29,30)/t15-,20-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269547
PNG
((1R,2S)-N-(4-(4-fluoro-3-(trifluoromethyl)phenyl)-...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1ccc(F)c(c1)C(F)(F)F)c1ncc(C)cn1
Show InChI InChI=1S/C24H23F4N7O4S/c1-13-11-29-21(30-12-13)20(39-4)14(2)40(36,37)34-23-33-32-22(18-6-5-7-19(31-18)38-3)35(23)15-8-9-17(25)16(10-15)24(26,27)28/h5-12,14,20H,1-4H3,(H,33,34)/t14-,20-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269560
PNG
((1R,2S)-N-(4-(2-fluorophenyl)-5-(6-methoxy-2-pyrid...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1ccccc1F)c1ncc(C)cn1
Show InChI InChI=1S/C23H24FN7O4S/c1-14-12-25-21(26-13-14)20(35-4)15(2)36(32,33)30-23-29-28-22(17-9-7-11-19(27-17)34-3)31(23)18-10-6-5-8-16(18)24/h5-13,15,20H,1-4H3,(H,29,30)/t15-,20-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269960
PNG
((1R,2S)—N-(4-(2,6-dimethoxyphenyl)-5-(6-metho...)
Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@@H](O)c2cnc(C)nc2)n1-c1c(OC)cccc1OC
Show InChI InChI=1S/C24H27N7O6S/c1-14(22(32)16-12-25-15(2)26-13-16)38(33,34)30-24-29-28-23(17-8-6-11-20(27-17)37-5)31(24)21-18(35-3)9-7-10-19(21)36-4/h6-14,22,32H,1-5H3,(H,29,30)/t14-,22+/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269964
PNG
((1R,2S)—N-(4-(2,6-dimethoxyphenyl)-5-(6-metho...)
Show SMILES CO[C@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1cnc(C)nc1
Show InChI InChI=1S/C25H29N7O6S/c1-15(23(38-6)17-13-26-16(2)27-14-17)39(33,34)31-25-30-29-24(18-9-7-12-21(28-18)37-5)32(25)22-19(35-3)10-8-11-20(22)36-4/h7-15,23H,1-6H3,(H,30,31)/t15-,23+/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269969
PNG
((2E)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-pyr...)
Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)C(\C)=C(/C)c2ncc(F)cn2)n1-c1c(OC)cccc1OC
Show InChI InChI=1S/C24H24FN7O5S/c1-14(22-26-12-16(25)13-27-22)15(2)38(33,34)31-24-30-29-23(17-8-6-11-20(28-17)37-5)32(24)21-18(35-3)9-7-10-19(21)36-4/h6-13H,1-5H3,(H,30,31)/b15-14+
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM270002
PNG
((1R,2R)—N-(4-(2,6-dimethoxyphenyl)-5-(5-methy...)
Show SMILES CO[C@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cncc(C)c2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C25H29N7O5S/c1-15-10-18(14-26-11-15)24-29-30-25(32(24)21-19(35-4)8-7-9-20(21)36-5)31-38(33,34)17(3)22(37-6)23-27-12-16(2)13-28-23/h7-14,17,22H,1-6H3,(H,30,31)/t17-,22+/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269563
PNG
((1R,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-p...)
Show SMILES CCO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cncc(C)c2)n1-c1c(OC)cccc1OC)c1ncc(F)cn1
Show InChI InChI=1S/C25H28FN7O5S/c1-6-38-22(23-28-13-18(26)14-29-23)16(3)39(34,35)32-25-31-30-24(17-10-15(2)11-27-12-17)33(25)21-19(36-4)8-7-9-20(21)37-5/h7-14,16,22H,6H2,1-5H3,(H,31,32)/t16-,22-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269569
PNG
((2R)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-pyr...)
Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@H](C)C(=O)N2CCCC2)n1-c1c(OC)cccc1OC
Show InChI InChI=1S/C23H28N6O6S/c1-15(22(30)28-13-5-6-14-28)36(31,32)27-23-26-25-21(16-9-7-12-19(24-16)35-4)29(23)20-17(33-2)10-8-11-18(20)34-3/h7-12,15H,5-6,13-14H2,1-4H3,(H,26,27)/t15-/m1/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269581
PNG
((1S,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-...)
Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@@H](OC(C)C)c2ncc(C)cn2)n1-c1c(OC)cccc1OC
Show InChI InChI=1S/C27H33N7O6S/c1-16(2)40-24(25-28-14-17(3)15-29-25)18(4)41(35,36)33-27-32-31-26(19-10-8-13-22(30-19)39-7)34(27)23-20(37-5)11-9-12-21(23)38-6/h8-16,18,24H,1-7H3,(H,32,33)/t18-,24+/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269587
PNG
((1R,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(2-methoxy-4-...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2ccnc(OC)c2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C25H29N7O6S/c1-15-13-27-23(28-14-15)22(38-6)16(2)39(33,34)31-25-30-29-24(17-10-11-26-20(12-17)37-5)32(25)21-18(35-3)8-7-9-19(21)36-4/h7-14,16,22H,1-6H3,(H,30,31)/t16-,22-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269594
PNG
((1S,2R)-N-(4-(2,6-dimethoxyphenyl)-5-(3-pyridinyl)...)
Show SMILES CCO[C@H]([C@@H](C)S(=O)(=O)Nc1nnc(-c2cccnc2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C25H29N7O5S/c1-6-37-22(23-27-13-16(2)14-28-23)17(3)38(33,34)31-25-30-29-24(18-9-8-12-26-15-18)32(25)21-19(35-4)10-7-11-20(21)36-5/h7-15,17,22H,6H2,1-5H3,(H,30,31)/t17-,22-/m1/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269598
PNG
((2R)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methoxy-3-pyr...)
Show SMILES COc1cncc(c1)-c1nnc(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)n1-c1c(OC)cccc1OC
Show InChI InChI=1S/C23H24FN7O5S/c1-14(8-20-26-11-16(24)12-27-20)37(32,33)30-23-29-28-22(15-9-17(34-2)13-25-10-15)31(23)21-18(35-3)6-5-7-19(21)36-4/h5-7,9-14H,8H2,1-4H3,(H,29,30)/t14-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM270006
PNG
((1S,2R)-1-(5-cyano-2-pyridinyl)-N-(4-(2,6-dimethox...)
Show SMILES CO[C@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cncc(C)c2)n1-c1c(OC)cccc1OC)c1ccc(cn1)C#N
Show InChI InChI=1S/C26H27N7O5S/c1-16-11-19(15-28-13-16)25-30-31-26(33(25)23-21(36-3)7-6-8-22(23)37-4)32-39(34,35)17(2)24(38-5)20-10-9-18(12-27)14-29-20/h6-11,13-15,17,24H,1-5H3,(H,31,32)/t17-,24+/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM270006
PNG
((1S,2R)-1-(5-cyano-2-pyridinyl)-N-(4-(2,6-dimethox...)
Show SMILES CO[C@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cncc(C)c2)n1-c1c(OC)cccc1OC)c1ccc(cn1)C#N
Show InChI InChI=1S/C26H27N7O5S/c1-16-11-19(15-28-13-16)25-30-31-26(33(25)23-21(36-3)7-6-8-22(23)37-4)32-39(34,35)17(2)24(38-5)20-10-9-18(12-27)14-29-20/h6-11,13-15,17,24H,1-5H3,(H,31,32)/t17-,24+/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM270014
PNG
((1R,2S)-1-(5-chloro-2-pyrimidinyl)-N-(4-(2,6-dimet...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)[C@@H](O)c2ncc(Cl)cn2)nnc1-c1cncc(C)c1
Show InChI InChI=1S/C23H24ClN7O5S/c1-13-8-15(10-25-9-13)22-28-29-23(31(22)19-17(35-3)6-5-7-18(19)36-4)30-37(33,34)14(2)20(32)21-26-11-16(24)12-27-21/h5-12,14,20,32H,1-4H3,(H,29,30)/t14-,20-/m1/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM270024
PNG
((1R,2S)—N-(4-(2,6-dimethoxyphenyl)-5-(6-metho...)
Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@H](C)[C@@H](O)c2cnc(C)cn2)n1-c1c(OC)cccc1OC
Show InChI InChI=1S/C24H27N7O6S/c1-14-12-26-17(13-25-14)22(32)15(2)38(33,34)30-24-29-28-23(16-8-6-11-20(27-16)37-5)31(24)21-18(35-3)9-7-10-19(21)36-4/h6-13,15,22,32H,1-5H3,(H,29,30)/t15-,22-/m1/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269899
PNG
((1R,2S)-1-(5-chloro-2-pyrimidinyl)-N-(4-(2,6-dimet...)
Show SMILES CCO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccnc2)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C24H26ClN7O5S/c1-5-37-21(22-27-13-17(25)14-28-22)15(2)38(33,34)31-24-30-29-23(16-8-7-11-26-12-16)32(24)20-18(35-3)9-6-10-19(20)36-4/h6-15,21H,5H2,1-4H3,(H,30,31)/t15-,21-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM270052
PNG
((2S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methyl-2-pyri...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)nnc1-c1cccc(C)n1
Show InChI InChI=1S/C23H24FN7O4S/c1-14-7-5-8-17(27-14)22-28-29-23(31(22)21-18(34-3)9-6-10-19(21)35-4)30-36(32,33)15(2)11-20-25-12-16(24)13-26-20/h5-10,12-13,15H,11H2,1-4H3,(H,29,30)/t15-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269619
PNG
((2S)-N-(4-(2,6-dimethoxyphenyl)-5-(2-methoxy-4-pyr...)
Show SMILES COc1cc(ccn1)-c1nnc(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)n1-c1c(OC)cccc1OC
Show InChI InChI=1S/C23H24FN7O5S/c1-14(10-19-26-12-16(24)13-27-19)37(32,33)30-23-29-28-22(15-8-9-25-20(11-15)36-4)31(23)21-17(34-2)6-5-7-18(21)35-3/h5-9,11-14H,10H2,1-4H3,(H,29,30)/t14-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269629
PNG
((2S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-ethoxy-2-pyri...)
Show SMILES CCOc1cccc(n1)-c1nnc(NS(=O)(=O)[C@H](C)Cc2ncc(F)cn2)n1-c1c(OC)cccc1OC
Show InChI InChI=1S/C24H26FN7O5S/c1-5-37-21-11-6-8-17(28-21)23-29-30-24(32(23)22-18(35-3)9-7-10-19(22)36-4)31-38(33,34)15(2)12-20-26-13-16(25)14-27-20/h6-11,13-15H,5,12H2,1-4H3,(H,30,31)/t15-/m1/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269645
PNG
((2S)-N-(5-(6-(1-azetidinylcarbonyl)-2-pyridinyl)-4...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)nnc1-c1cccc(n1)C(=O)N1CCC1
Show InChI InChI=1S/C26H27FN8O5S/c1-16(13-22-28-14-17(27)15-29-22)41(37,38)33-26-32-31-24(35(26)23-20(39-2)9-5-10-21(23)40-3)18-7-4-8-19(30-18)25(36)34-11-6-12-34/h4-5,7-10,14-16H,6,11-13H2,1-3H3,(H,32,33)/t16-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269655
PNG
((2S)-N-(5-(6-(difluoromethoxy)-2-pyridinyl)-4-(2,6...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)nnc1-c1cccc(OC(F)F)n1
Show InChI InChI=1S/C23H22F3N7O5S/c1-13(10-18-27-11-14(24)12-28-18)39(34,35)32-23-31-30-21(15-6-4-9-19(29-15)38-22(25)26)33(23)20-16(36-2)7-5-8-17(20)37-3/h4-9,11-13,22H,10H2,1-3H3,(H,31,32)/t13-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269659
PNG
((1R,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(3-pyridinyl)...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccnc2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C24H27N7O5S/c1-15-12-26-22(27-13-15)21(36-5)16(2)37(32,33)30-24-29-28-23(17-8-7-11-25-14-17)31(24)20-18(34-3)9-6-10-19(20)35-4/h6-14,16,21H,1-5H3,(H,29,30)/t16-,21-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM270076
PNG
((1R,2S)-1-(5-bromo-6-methylpyridin-2-yl)-N-(4-(2,6...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](O)c2ccc(Br)c(C)n2)nnc1-c1cccnc1
Show InChI InChI=1S/C24H25BrN6O5S/c1-14-17(25)10-11-18(27-14)22(32)15(2)37(33,34)30-24-29-28-23(16-7-6-12-26-13-16)31(24)21-19(35-3)8-5-9-20(21)36-4/h5-13,15,22,32H,1-4H3,(H,29,30)/t15-,22-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM270092
PNG
((2S,3R)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-...)
Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@@H](C)n2cc(C)cn2)n1-c1c(OC)cccc1OC
Show InChI InChI=1S/C24H29N7O5S/c1-15-13-25-30(14-15)16(2)17(3)37(32,33)29-24-28-27-23(18-9-7-12-21(26-18)36-6)31(24)22-19(34-4)10-8-11-20(22)35-5/h7-14,16-17H,1-6H3,(H,28,29)/t16-,17+/m1/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM270096
PNG
((2R)-N-(4-(2,6-dimethoxyphenyl)-5-(6-(methylamino)...)
Show SMILES CNc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)n1-c1c(OC)cccc1OC
Show InChI InChI=1S/C23H25FN8O4S/c1-14(11-20-26-12-15(24)13-27-20)37(33,34)31-23-30-29-22(16-7-5-10-19(25-2)28-16)32(23)21-17(35-3)8-6-9-18(21)36-4/h5-10,12-14H,11H2,1-4H3,(H,25,28)(H,30,31)/t14-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM270107
PNG
((1R,2S)-N-(4-(2,6-dimethylphenyl)-5-(5-methyl-3-py...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cncc(C)c2)n1-c1c(C)cccc1C)c1ncc(C)cn1
Show InChI InChI=1S/C25H29N7O3S/c1-15-10-20(14-26-11-15)24-29-30-25(32(24)21-17(3)8-7-9-18(21)4)31-36(33,34)19(5)22(35-6)23-27-12-16(2)13-28-23/h7-14,19,22H,1-6H3,(H,30,31)/t19-,22-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM270109
PNG
((1R,2S)-N-(4-(2,6-dichlorophenyl)-5-(5-methyl-3-py...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cncc(C)c2)n1-c1c(Cl)cccc1Cl)c1ncc(C)cn1
Show InChI InChI=1S/C23H23Cl2N7O3S/c1-13-8-16(12-26-9-13)22-29-30-23(32(22)19-17(24)6-5-7-18(19)25)31-36(33,34)15(3)20(35-4)21-27-10-14(2)11-28-21/h5-12,15,20H,1-4H3,(H,30,31)/t15-,20-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM270116
PNG
((2S,3R)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-p...)
Show SMILES COc1cnc(nc1)[C@@H](C)[C@H](C)S(=O)(=O)Nc1nnc(-c2cncc(C)c2)n1-c1c(OC)cccc1OC
Show InChI InChI=1S/C25H29N7O5S/c1-15-10-18(12-26-11-15)24-29-30-25(32(24)22-20(36-5)8-7-9-21(22)37-6)31-38(33,34)17(3)16(2)23-27-13-19(35-4)14-28-23/h7-14,16-17H,1-6H3,(H,30,31)/t16-,17-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM270126
PNG
((1R,2S)-N-(4-(2-fluoro-6-methoxyphenyl)-5-(5-methy...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cncc(C)c2)n1-c1c(F)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C24H26FN7O4S/c1-14-9-17(13-26-10-14)23-29-30-24(32(23)20-18(25)7-6-8-19(20)35-4)31-37(33,34)16(3)21(36-5)22-27-11-15(2)12-28-22/h6-13,16,21H,1-5H3,(H,30,31)/t16-,21-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM270144
PNG
((1R,2S)-1-(5-chloro-2-pyridinyl)-N-(4-(4,6-dimetho...)
Show SMILES CO[C@H]([C@@H](C)S(=O)(=O)Nc1nnc(-c2cccnc2)n1-c1c(OC)cccc1OC)c1ccc(Cl)cn1
Show InChI InChI=1S/C24H25ClN6O5S/c1-15(22(36-4)18-11-10-17(25)14-27-18)37(32,33)30-24-29-28-23(16-7-6-12-26-13-16)31(24)21-19(34-2)8-5-9-20(21)35-3/h5-15,22H,1-4H3,(H,29,30)/t15-,22-/m1/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM270145
PNG
((1R,2S)-1-(5-chloro-2-pyridinyl)-N-(4-(2,4-dimetho...)
Show SMILES CO[C@H]([C@@H](C)S(=O)(=O)Nc1nnc(-c2cccnc2)n1-c1c(OC)ccnc1OC)c1ccc(Cl)cn1
Show InChI InChI=1S/C23H24ClN7O5S/c1-14(20(35-3)17-8-7-16(24)13-27-17)37(32,33)30-23-29-28-21(15-6-5-10-25-12-15)31(23)19-18(34-2)9-11-26-22(19)36-4/h5-14,20H,1-4H3,(H,29,30)/t14-,20-/m1/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269676
PNG
((1R,2S)-1-(6-chloro-2-pyridinyl)-N-(4-(2,6-dimetho...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)[C@H](O)c2cccc(Cl)n2)nnc1-c1cccnc1
Show InChI InChI=1S/C23H23ClN6O5S/c1-14(21(31)16-8-4-11-19(24)26-16)36(32,33)29-23-28-27-22(15-7-6-12-25-13-15)30(23)20-17(34-2)9-5-10-18(20)35-3/h4-14,21,31H,1-3H3,(H,28,29)/t14-,21+/m1/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269694
PNG
((2S)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-pyri...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)nnc1-c1cncc(C)c1
Show InChI InChI=1S/C23H24FN7O4S/c1-14-8-16(11-25-10-14)22-28-29-23(31(22)21-18(34-3)6-5-7-19(21)35-4)30-36(32,33)15(2)9-20-26-12-17(24)13-27-20/h5-8,10-13,15H,9H2,1-4H3,(H,29,30)/t15-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269701
PNG
((2S)-N-(4-(2,6-dimethoxyphenyl)-5-(4-methyl-3-pyri...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)nnc1-c1cnccc1C
Show InChI InChI=1S/C23H24FN7O4S/c1-14-8-9-25-13-17(14)22-28-29-23(31(22)21-18(34-3)6-5-7-19(21)35-4)30-36(32,33)15(2)10-20-26-11-16(24)12-27-20/h5-9,11-13,15H,10H2,1-4H3,(H,29,30)/t15-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269702
PNG
((2S)-N-(4-(2,6-dimethoxyphenyl)-5-(4-methyl-3-pyri...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)nnc1-c1cnccc1C
Show InChI InChI=1S/C23H24FN7O4S/c1-14-8-9-25-13-17(14)22-28-29-23(31(22)21-18(34-3)6-5-7-19(21)35-4)30-36(32,33)15(2)10-20-26-11-16(24)12-27-20/h5-9,11-13,15H,10H2,1-4H3,(H,29,30)/t15-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269710
PNG
((2S)-N-(4-(2,6-dimethoxyphenyl)-5-(5-fluoro-3-pyri...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)nnc1-c1cncc(F)c1
Show InChI InChI=1S/C22H21F2N7O4S/c1-13(7-19-26-11-16(24)12-27-19)36(32,33)30-22-29-28-21(14-8-15(23)10-25-9-14)31(22)20-17(34-2)5-4-6-18(20)35-3/h4-6,8-13H,7H2,1-3H3,(H,29,30)/t13-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM270157
PNG
((1R,2S)—N-(4-(2,6-dimethoxyphenyl)-5-(5-methy...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cc(C)cnn2)n1-c1c(OC)cccc1OC)C1CC(C)(C)C1
Show InChI InChI=1S/C25H34N6O5S/c1-15-11-18(27-26-14-15)23-28-29-24(31(23)21-19(34-5)9-8-10-20(21)35-6)30-37(32,33)16(2)22(36-7)17-12-25(3,4)13-17/h8-11,14,16-17,22H,12-13H2,1-7H3,(H,29,30)/t16-,22-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM270162
PNG
((1R,2S)—N-(4-(4,6-dimethoxypyrimidin-5-yl)-5-...)
Show SMILES CO[C@@H]([C@@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)ncnc1OC)C1CC(C)(C)C1
Show InChI InChI=1S/C24H33N7O6S/c1-14(19(35-5)15-11-24(2,3)12-15)38(32,33)30-23-29-28-20(16-9-8-10-17(27-16)34-4)31(23)18-21(36-6)25-13-26-22(18)37-7/h8-10,13-15,19H,11-12H2,1-7H3,(H,29,30)/t14-,19+/m1/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM270174
PNG
((1R,2R)—N-(4-(2,6-dimethoxyphenyl)-5-(5-methy...)
Show SMILES COc1cnc(nc1)[C@@H](OC(C)C)[C@@H](C)S(=O)(=O)Nc1nnc(-c2cncc(C)c2)n1-c1c(OC)cccc1OC
Show InChI InChI=1S/C27H33N7O6S/c1-16(2)40-24(25-29-14-20(37-5)15-30-25)18(4)41(35,36)33-27-32-31-26(19-11-17(3)12-28-13-19)34(27)23-21(38-6)9-8-10-22(23)39-7/h8-16,18,24H,1-7H3,(H,32,33)/t18-,24+/m1/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM270181
PNG
((1R,2S)-1-(5-(3,6-dihydro-2H-pyran-4-yl)pyrimidin-...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cncc(C)c2)n1-c1c(OC)cccc1OC)c1ncc(cn1)C1=CCOCC1
Show InChI InChI=1S/C29H33N7O6S/c1-18-13-21(15-30-14-18)28-33-34-29(36(28)25-23(39-3)7-6-8-24(25)40-4)35-43(37,38)19(2)26(41-5)27-31-16-22(17-32-27)20-9-11-42-12-10-20/h6-9,13-17,19,26H,10-12H2,1-5H3,(H,34,35)/t19-,26-/m0/s1
PDB

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n/an/an/an/a 15n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM270184
PNG
((1R,2S)—N-(4-(2,6-dimethoxyphenyl)-5-(5-methy...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cncc(C)c2)n1-c1c(OC)cccc1OC)c1ncc(cn1)-c1cccnc1
Show InChI InChI=1S/C29H30N8O5S/c1-18-12-21(15-31-13-18)28-34-35-29(37(28)25-23(40-3)9-6-10-24(25)41-4)36-43(38,39)19(2)26(42-5)27-32-16-22(17-33-27)20-8-7-11-30-14-20/h6-17,19,26H,1-5H3,(H,35,36)/t19-,26-/m0/s1
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n/an/an/an/a 3.60n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM270185
PNG
((1R,2S)—N-(4-(2,6-dimethoxyphenyl)-5-(5-methy...)
Show SMILES CN[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cncc(C)c2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C25H30N8O4S/c1-15-10-18(14-27-11-15)24-30-31-25(33(24)22-19(36-5)8-7-9-20(22)37-6)32-38(34,35)17(3)21(26-4)23-28-12-16(2)13-29-23/h7-14,17,21,26H,1-6H3,(H,31,32)/t17-,21-/m0/s1
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n/an/an/an/a 5.90n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM270191
PNG
((1R,2S)—N-(4-(2,6-dimethoxyphenyl)-5-(6-metho...)
Show SMILES COC1CN(C1)[C@H]([C@@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C28H34N8O6S/c1-17-13-29-26(30-14-17)24(35-15-19(16-35)39-3)18(2)43(37,38)34-28-33-32-27(20-9-7-12-23(31-20)42-6)36(28)25-21(40-4)10-8-11-22(25)41-5/h7-14,18-19,24H,15-16H2,1-6H3,(H,33,34)/t18-,24-/m1/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM270191
PNG
((1R,2S)—N-(4-(2,6-dimethoxyphenyl)-5-(6-metho...)
Show SMILES COC1CN(C1)[C@H]([C@@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C28H34N8O6S/c1-17-13-29-26(30-14-17)24(35-15-19(16-35)39-3)18(2)43(37,38)34-28-33-32-27(20-9-7-12-23(31-20)42-6)36(28)25-21(40-4)10-8-11-22(25)41-5/h7-14,18-19,24H,15-16H2,1-6H3,(H,33,34)/t18-,24-/m1/s1
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n/an/an/an/a 0.0950n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM270199
PNG
((1R,2S)—N-(4-(2,6-dimethoxyphenyl)-5-(pyridin...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)[C@@H](O)c2ccc(C)nn2)nnc1-c1cccnc1
Show InChI InChI=1S/C23H25N7O5S/c1-14-10-11-17(26-25-14)21(31)15(2)36(32,33)29-23-28-27-22(16-7-6-12-24-13-16)30(23)20-18(34-3)8-5-9-19(20)35-4/h5-13,15,21,31H,1-4H3,(H,28,29)/t15-,21-/m1/s1
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n/an/an/an/a 3.80n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%