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Found 24 Enz. Inhib. hit(s) with all data for entry = 456
TargetBeta-secretase 1(Homo sapiens (Human))
H. Lundbeck

US Patent
LigandPNGBDBM270566(N-(3-((2R,3S,5S)-6-amino-3,5-difluoro-2,5-dimethyl...)
Affinity DataKi:  3.60nM ΔG°:  -48.2kJ/molepH: 4.5 T: 2°CAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
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TargetBeta-secretase 1(Homo sapiens (Human))
H. Lundbeck

US Patent
LigandPNGBDBM270565(N-(3-((2R,3S,5S)-6-amino-3,5-difluoro-2,5-dimethyl...)
Affinity DataKi:  4.10nM ΔG°:  -47.9kJ/molepH: 4.5 T: 2°CAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
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TargetBeta-secretase 1(Homo sapiens (Human))
H. Lundbeck

US Patent
LigandPNGBDBM270568(N-(3-((2R,3S,5S)-6-amino-3,5-difluoro-2,5-dimethyl...)
Affinity DataKi:  4.30nM ΔG°:  -47.8kJ/molepH: 4.5 T: 2°CAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
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TargetBeta-secretase 1(Homo sapiens (Human))
H. Lundbeck

US Patent
LigandPNGBDBM270562(N-(3-((2R,3S,5R)-6-amino-3,5-difluoro-2,5-dimethyl...)
Affinity DataKi:  6.80nM ΔG°:  -46.6kJ/molepH: 4.5 T: 2°CAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
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TargetBeta-secretase 1(Homo sapiens (Human))
H. Lundbeck

US Patent
LigandPNGBDBM270547(N-(3-((2R,3S,5S)-6-amino-3,5-difluoro-2,5-dimethyl...)
Affinity DataKi:  20nM ΔG°:  -43.9kJ/molepH: 4.5 T: 2°CAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
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TargetBeta-secretase 1(Homo sapiens (Human))
H. Lundbeck

US Patent
LigandPNGBDBM270546(N-(3-((2R,3S,5S)-6-amino-3,5-difluoro-2,5-dimethyl...)
Affinity DataKi:  21nM ΔG°:  -43.8kJ/molepH: 4.5 T: 2°CAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
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TargetBeta-secretase 1(Homo sapiens (Human))
H. Lundbeck

US Patent
LigandPNGBDBM270547(N-(3-((2R,3S,5S)-6-amino-3,5-difluoro-2,5-dimethyl...)
Affinity DataKi:  23nM ΔG°:  -43.6kJ/molepH: 4.5 T: 2°CAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
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TargetBeta-secretase 1(Homo sapiens (Human))
H. Lundbeck

US Patent
LigandPNGBDBM270546(N-(3-((2R,3S,5S)-6-amino-3,5-difluoro-2,5-dimethyl...)
Affinity DataKi:  26nM ΔG°:  -43.3kJ/molepH: 4.5 T: 2°CAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
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TargetBeta-secretase 1(Homo sapiens (Human))
H. Lundbeck

US Patent
LigandPNGBDBM270545(N-(3-((2R,3S,5S)-6-Amino-3,5-difluoro-2,5-dimethyl...)
Affinity DataKi:  30nM ΔG°:  -42.9kJ/molepH: 4.5 T: 2°CAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
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TargetBeta-secretase 1(Homo sapiens (Human))
H. Lundbeck

US Patent
LigandPNGBDBM270553(N-(3-((2R,3S,5R)-6-amino-3,5-difluoro-2,5-dimethyl...)
Affinity DataKi:  36nM ΔG°:  -42.5kJ/molepH: 4.5 T: 2°CAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
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TargetBeta-secretase 1(Homo sapiens (Human))
H. Lundbeck

US Patent
LigandPNGBDBM270551(N-(3-((2R,3S,5R)-6-amino-3,5-difluoro-2,5-dimethyl...)
Affinity DataKi:  39nM ΔG°:  -42.3kJ/molepH: 4.5 T: 2°CAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
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TargetBeta-secretase 1(Homo sapiens (Human))
H. Lundbeck

US Patent
LigandPNGBDBM270561(N-(3-((2R,3S,5R)-6-amino-3,5-difluoro-2,5-dimethyl...)
Affinity DataKi:  39nM ΔG°:  -42.3kJ/molepH: 4.5 T: 2°CAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
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TargetBeta-secretase 1(Homo sapiens (Human))
H. Lundbeck

US Patent
LigandPNGBDBM270558(N-(3-((2R,3S,5R)-6-amino-3,5-difluoro-2,5-dimethyl...)
Affinity DataKi:  45nM ΔG°:  -41.9kJ/molepH: 4.5 T: 2°CAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
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TargetBeta-secretase 1(Homo sapiens (Human))
H. Lundbeck

US Patent
LigandPNGBDBM270549(N-(3-((2R,3S,5R)-6-amino-3,5-difluoro-2,5-dimethyl...)
Affinity DataKi:  51nM ΔG°:  -41.6kJ/molepH: 4.5 T: 2°CAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetBeta-secretase 1(Homo sapiens (Human))
H. Lundbeck

US Patent
LigandPNGBDBM270550(N-(3-((2R,3S,5R)-6-amino-3,5-difluoro-2,5-dimethyl...)
Affinity DataKi:  58nM ΔG°:  -41.3kJ/molepH: 4.5 T: 2°CAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetBeta-secretase 1(Homo sapiens (Human))
H. Lundbeck

US Patent
LigandPNGBDBM270551(N-(3-((2R,3S,5R)-6-amino-3,5-difluoro-2,5-dimethyl...)
Affinity DataKi:  58nM ΔG°:  -41.3kJ/molepH: 4.5 T: 2°CAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
H. Lundbeck

US Patent
LigandPNGBDBM270557(N-(3-((2R,3S,5R)-6-amino-3,5-difluoro-2,5-dimethyl...)
Affinity DataKi:  62nM ΔG°:  -41.1kJ/molepH: 4.5 T: 2°CAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetBeta-secretase 1(Homo sapiens (Human))
H. Lundbeck

US Patent
LigandPNGBDBM270567(N-(3-((2R,3R,5S)-6-amino-3,5-difluoro-2,5-dimethyl...)
Affinity DataKi:  81nM ΔG°:  -40.5kJ/molepH: 4.5 T: 2°CAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetBeta-secretase 1(Homo sapiens (Human))
H. Lundbeck

US Patent
LigandPNGBDBM270548(N-(3-((2R,3S,5R)-6-amino-3,5-difluoro-2,5-dimethyl...)
Affinity DataKi:  98nM ΔG°:  -40.0kJ/molepH: 4.5 T: 2°CAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetBeta-secretase 1(Homo sapiens (Human))
H. Lundbeck

US Patent
LigandPNGBDBM270556(N-(3-((2R,3S,5R)-6-amino-3,5-difluoro-2,5-dimethyl...)
Affinity DataKi:  99nM ΔG°:  -40.0kJ/molepH: 4.5 T: 2°CAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetBeta-secretase 1(Homo sapiens (Human))
H. Lundbeck

US Patent
LigandPNGBDBM270559(N-(3-((2R,3S,5R)-6-amino-3,5-difluoro-2,5-dimethyl...)
Affinity DataKi:  100nM ΔG°:  -40.0kJ/molepH: 4.5 T: 2°CAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetBeta-secretase 1(Homo sapiens (Human))
H. Lundbeck

US Patent
LigandPNGBDBM270555(N-(3-((2R,3S,5R)-6-amino-3,5-difluoro-2,5-dimethyl...)
Affinity DataKi:  190nM ΔG°:  -38.4kJ/molepH: 4.5 T: 2°CAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetBeta-secretase 1(Homo sapiens (Human))
H. Lundbeck

US Patent
LigandPNGBDBM270560(N-(3-((2R,3S,5R)-6-amino-3,5-difluoro-2,5-dimethyl...)
Affinity DataKi:  220nM ΔG°:  -38.0kJ/molepH: 4.5 T: 2°CAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
H. Lundbeck

US Patent
LigandPNGBDBM270554(N-(3-((2R,3S,5R)-6-amino-3,5-difluoro-2,5-dimethyl...)
Affinity DataKi:  820nM ΔG°:  -34.7kJ/molepH: 4.5 T: 2°CAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent